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Volume 48, Issue 6

1 June 1999

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Table of Contents

ISSN 0012-1797

EISSN 1939-327X

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Activators of peroxisome proliferator-activated receptor-alpha induce the expression of the uncoupling protein-3 gene in skeletal muscle: a potential mechanism for the lipid intake-dependent activation of uncoupling protein-3 gene expression at birth.

S Brun; M C Carmona; T Mampel; O Viñas; M Giralt; R Iglesias; F Villarroya

Abstract

View articletitled, Activators of peroxisome proliferator-activated receptor-alpha induce the expression of the uncoupling protein-3 gene in skeletal muscle: a potential mechanism for the lipid intake-dependent activation of uncoupling protein-3 gene expression at birth.

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Topics: gene expression , genes , lipids , peroxisome , skeletal muscles

Diabetes June 1999, Vol.48, 1217-1222. doi:https://doi.org/10.2337/diabetes.48.6.1217

Transfection of human pancreatic islets with an anti-apoptotic gene (bcl-2) protects beta-cells from cytokine-induced destruction.

A Rabinovitch; W Suarez-Pinzon; K Strynadka; Q Ju; D Edelstein; M Brownlee; G S Korbutt; R V Rajotte

Abstract

View articletitled, Transfection of human pancreatic islets with an anti-apoptotic gene (bcl-2) protects beta-cells from cytokine-induced destruction.

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Topics: bcl2 gene , cytokine , endocrine pancreas , genes , transfection

Diabetes June 1999, Vol.48, 1223-1229. doi:https://doi.org/10.2337/diabetes.48.6.1223

Impaired beta-cell functions induced by chronic exposure of cultured human pancreatic islets to high glucose.

S Marshak; G Leibowitz; F Bertuzzi; C Socci; N Kaiser; D J Gross; E Cerasi; D Melloul

Abstract

View articletitled, Impaired beta-cell functions induced by chronic exposure of cultured human pancreatic islets to high glucose.

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Topics: endocrine pancreas , glucose , pancreatic beta cell

Diabetes June 1999, Vol.48, 1230-1236. doi:https://doi.org/10.2337/diabetes.48.6.1230

Insulin receptor-related receptor is expressed in pancreatic beta-cells and stimulates tyrosine phosphorylation of insulin receptor substrate-1 and -2.

I Hirayama; H Tamemoto; H Yokota; S K Kubo; J Wang; H Kuwano; Y Nagamachi; T Takeuchi; T Izumi

Abstract

View articletitled, Insulin receptor-related receptor is expressed in pancreatic beta-cells and stimulates tyrosine phosphorylation of insulin receptor substrate-1 and -2.

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Topics: insulin , insulin receptor , pancreas , phosphorylation , tyrosine

Diabetes June 1999, Vol.48, 1237-1244. doi:https://doi.org/10.2337/diabetes.48.6.1237

Impaired free fatty acid uptake in skeletal muscle but not in myocardium in patients with impaired glucose tolerance: studies with PET and 14(R,S)-[18F]fluoro-6-thia-heptadecanoic acid.

A K Turpeinen; T O Takala; P Nuutila; T Axelin; M Luotolahti; M Haaparanta; J Bergman; H Hämäläinen; H Iida; M Mäki; M I Uusitupa; J Knuuti

Abstract

View articletitled, Impaired free fatty acid uptake in skeletal muscle but not in myocardium in patients with impaired glucose tolerance: studies with PET and 14(R,S)-[18F]fluoro-6-thia-heptadecanoic acid.

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Topics: glucose intolerance , myocardium , nonesterified fatty acids , positron-emission tomography , skeletal muscles

Diabetes June 1999, Vol.48, 1245-1250. doi:https://doi.org/10.2337/diabetes.48.6.1245

Modifications of citric acid cycle activity and gluconeogenesis in streptozotocin-induced diabetes and effects of metformin.

V Large; M Beylot

Abstract

View articletitled, Modifications of citric acid cycle activity and gluconeogenesis in streptozotocin-induced diabetes and effects of metformin.

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Topics: citric acid cycle , gluconeogenesis , metformin , streptozocin

Diabetes June 1999, Vol.48, 1251-1257. doi:https://doi.org/10.2337/diabetes.48.6.1251

Triglyceride-induced diabetes associated with familial lipoprotein lipase deficiency.

G Mingrone; F L Henriksen; A V Greco; L N Krogh; E Capristo; A Gastaldelli; M Castagneto; E Ferrannini; G Gasbarrini; H Beck-Nielsen

Abstract

View articletitled, Triglyceride-induced diabetes associated with familial lipoprotein lipase deficiency.

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Topics: familial lipoprotein lipase deficiency , triglycerides

Diabetes June 1999, Vol.48, 1258-1263. doi:https://doi.org/10.2337/diabetes.48.6.1258

Acute intravenous leptin infusion increases glucose turnover but not skeletal muscle glucose uptake in ob/ob mice.

R Burcelin; S Kamohara; J Li; G S Tannenbaum; M J Charron; J M Friedman

Abstract

View articletitled, Acute intravenous leptin infusion increases glucose turnover but not skeletal muscle glucose uptake in ob/ob mice.

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Topics: glucose , glucose uptake , infusion procedures , leptin , mice

Diabetes June 1999, Vol.48, 1264-1269. doi:https://doi.org/10.2337/diabetes.48.6.1264

Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade.

M E Griffin; M J Marcucci; G W Cline; K Bell; N Barucci; D Lee; L J Goodyear; E W Kraegen; M F White; G I Shulman

Abstract

View articletitled, Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade.

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Topics: insulin , insulin resistance , protein kinase c-theta , signal transduction

Diabetes June 1999, Vol.48, 1270-1274. doi:https://doi.org/10.2337/diabetes.48.6.1270

Low plasma leptin levels contribute to diabetic hyperphagia in rats.

D K Sindelar; P J Havel; R J Seeley; C W Wilkinson; S C Woods; M W Schwartz

Abstract

View articletitled, Low plasma leptin levels contribute to diabetic hyperphagia in rats.

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Topics: hyperphagia , leptin , plasma , rats

Diabetes June 1999, Vol.48, 1275-1280. doi:https://doi.org/10.2337/diabetes.48.6.1275

Opposite effects of acute hypoglycemia and acute hyperglycemia on glucose transport and glucose transporters in perfused rat skeletal muscle.

J M Mathoo; Z Q Shi; A Klip; M Vranic

Abstract

View articletitled, Opposite effects of acute hypoglycemia and acute hyperglycemia on glucose transport and glucose transporters in perfused rat skeletal muscle.

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Topics: glucose transport , glucose transporter , hyperglycemia, acute , hypoglycemia , skeletal muscles

Diabetes June 1999, Vol.48, 1281-1288. doi:https://doi.org/10.2337/diabetes.48.6.1281

Effects of aggressive cholesterol lowering and low-dose anticoagulation on clinical and angiographic outcomes in patients with diabetes: the Post Coronary Artery Bypass Graft Trial.

B J Hoogwerf; A Waness; M Cressman; J Canner; L Campeau; M Domanski; N Geller; A Herd; A Hickey; D B Hunninghake; G L Knatterud; C White

Abstract

View articletitled, Effects of aggressive cholesterol lowering and low-dose anticoagulation on clinical and angiographic outcomes in patients with diabetes: the Post Coronary Artery Bypass Graft Trial.

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Topics: angiogram , anticoagulation , cholesterol , coronary artery bypass surgery

Diabetes June 1999, Vol.48, 1289-1294. doi:https://doi.org/10.2337/diabetes.48.6.1289

Power spectral analysis of heart rate variability during hyperinsulinemia in nondiabetic offspring of type 2 diabetic patients: evidence for possible early autonomic dysfunction in insulin-resistant subjects.

T Laitinen; I K Vauhkonen; L K Niskanen; J E Hartikainen; E A Länsimies; M I Uusitupa; M Laakso

Abstract

View articletitled, Power spectral analysis of heart rate variability during hyperinsulinemia in nondiabetic offspring of type 2 diabetic patients: evidence for possible early autonomic dysfunction in insulin-resistant subjects.

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Topics: autonomic dysfunction , heart rate variability , hyperinsulinism , insulin , spectrum analysis

Diabetes June 1999, Vol.48, 1295-1299. doi:https://doi.org/10.2337/diabetes.48.6.1295

Endothelium-dependent vasodilatation, plasma markers of endothelial function, and adrenergic vasoconstrictor responses in type 1 diabetes under near-normoglycemic conditions.

F C Huvers; P W De Leeuw; A J Houben; C H De Haan; K Hamulyak; H Schouten; B H Wolffenbuttel; N C Schaper

Abstract

View articletitled, Endothelium-dependent vasodilatation, plasma markers of endothelial function, and adrenergic vasoconstrictor responses in type 1 diabetes under near-normoglycemic conditions.

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Topics: blood glucose normal , diabetes mellitus, type 1 , endothelium , plasma , vasoconstrictor agents

Diabetes June 1999, Vol.48, 1300-1307. doi:https://doi.org/10.2337/diabetes.48.6.1300

Dietary glycotoxins: inhibition of reactive products by aminoguanidine facilitates renal clearance and reduces tissue sequestration.

C He; J Sabol; T Mitsuhashi; H Vlassara

Abstract

View articletitled, Dietary glycotoxins: inhibition of reactive products by aminoguanidine facilitates renal clearance and reduces tissue sequestration.

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Topics: diet , pimagedine , renal clearance function

Diabetes June 1999, Vol.48, 1308-1315. doi:https://doi.org/10.2337/diabetes.48.6.1308

Protein kinase C activity is acutely regulated by plasma glucose concentration in human monocytes in vivo.

G Ceolotto; A Gallo; M Miola; M Sartori; R Trevisan; S Del Prato; A Semplicini; A Avogaro

Abstract

View articletitled, Protein kinase C activity is acutely regulated by plasma glucose concentration in human monocytes in vivo.

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Topics: monocytes , plasma glucose , protein kinase c

Diabetes June 1999, Vol.48, 1316-1322. doi:https://doi.org/10.2337/diabetes.48.6.1316

Human diabetes is associated with hyperreactivity of vascular smooth muscle cells due to altered subcellular Ca2+ distribution.

E Fleischhacker; V E Esenabhalu; M Spitaler; S Holzmann; F Skrabal; B Koidl; G M Kostner; W F Graier

Abstract

View articletitled, Human diabetes is associated with hyperreactivity of vascular smooth muscle cells due to altered subcellular Ca2+ distribution.

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Topics: calcium ions , muscle, smooth, vascular

Diabetes June 1999, Vol.48, 1323-1330. doi:https://doi.org/10.2337/diabetes.48.6.1323

Glycated low-density lipoprotein attenuates shear stress-induced nitric oxide synthesis by inhibition of shear stress-activated L-arginine uptake in endothelial cells.

K Posch; S Simecek; T C Wascher; G Jürgens; S Baumgartner-Parzer; G M Kostner; W F Graier

Abstract

View articletitled, Glycated low-density lipoprotein attenuates shear stress-induced nitric oxide synthesis by inhibition of shear stress-activated L-arginine uptake in endothelial cells.

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Topics: arginine , endothelial cells , low-density lipoproteins , nitric oxide , stress

Diabetes June 1999, Vol.48, 1331-1337. doi:https://doi.org/10.2337/diabetes.48.6.1331

A novel polymorphism in the aldose reductase gene promoter region is strongly associated with diabetic retinopathy in adolescents with type 1 diabetes.

Y L Kao; K Donaghue; A Chan; J Knight; M Silink

View articletitled, A novel polymorphism in the aldose reductase gene promoter region is strongly associated with diabetic retinopathy in adolescents with type 1 diabetes.

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Topics: adolescent , aldehyde reductase , diabetes mellitus, type 1 , diabetic retinopathy , genes

Diabetes June 1999, Vol.48, 1338-1340. doi:https://doi.org/10.2337/diabetes.48.6.1338

Identification of the high-affinity tolbutamide site on the SUR1 subunit of the K(ATP) channel.

R Ashfield; F M Gribble; S J Ashcroft; F M Ashcroft

Abstract

View articletitled, Identification of the high-affinity tolbutamide site on the SUR1 subunit of the K(ATP) channel.

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Topics: abcc8 gene , affinity , tolbutamide

Diabetes June 1999, Vol.48, 1341-1347. doi:https://doi.org/10.2337/diabetes.48.6.1341

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Activators of peroxisome proliferator-activated receptor-alpha induce the expression of the uncoupling protein-3 gene in skeletal muscle: a potential mechanism for the lipid intake-dependent activation of uncoupling protein-3 gene expression at birth.

Transfection of human pancreatic islets with an anti-apoptotic gene (bcl-2) protects beta-cells from cytokine-induced destruction.

Impaired beta-cell functions induced by chronic exposure of cultured human pancreatic islets to high glucose.

Insulin receptor-related receptor is expressed in pancreatic beta-cells and stimulates tyrosine phosphorylation of insulin receptor substrate-1 and -2.

Impaired free fatty acid uptake in skeletal muscle but not in myocardium in patients with impaired glucose tolerance: studies with PET and 14(R,S)-[18F]fluoro-6-thia-heptadecanoic acid.

Modifications of citric acid cycle activity and gluconeogenesis in streptozotocin-induced diabetes and effects of metformin.

Triglyceride-induced diabetes associated with familial lipoprotein lipase deficiency.

Acute intravenous leptin infusion increases glucose turnover but not skeletal muscle glucose uptake in ob/ob mice.

Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade.

Low plasma leptin levels contribute to diabetic hyperphagia in rats.

Opposite effects of acute hypoglycemia and acute hyperglycemia on glucose transport and glucose transporters in perfused rat skeletal muscle.

Effects of aggressive cholesterol lowering and low-dose anticoagulation on clinical and angiographic outcomes in patients with diabetes: the Post Coronary Artery Bypass Graft Trial.

Power spectral analysis of heart rate variability during hyperinsulinemia in nondiabetic offspring of type 2 diabetic patients: evidence for possible early autonomic dysfunction in insulin-resistant subjects.

Endothelium-dependent vasodilatation, plasma markers of endothelial function, and adrenergic vasoconstrictor responses in type 1 diabetes under near-normoglycemic conditions.

Dietary glycotoxins: inhibition of reactive products by aminoguanidine facilitates renal clearance and reduces tissue sequestration.

Protein kinase C activity is acutely regulated by plasma glucose concentration in human monocytes in vivo.

Human diabetes is associated with hyperreactivity of vascular smooth muscle cells due to altered subcellular Ca2+ distribution.

Glycated low-density lipoprotein attenuates shear stress-induced nitric oxide synthesis by inhibition of shear stress-activated L-arginine uptake in endothelial cells.

A novel polymorphism in the aldose reductase gene promoter region is strongly associated with diabetic retinopathy in adolescents with type 1 diabetes.

Identification of the high-affinity tolbutamide site on the SUR1 subunit of the K(ATP) channel.

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