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Comparative genetics of type 1 diabetes and autoimmune disease: common loci, common pathways?
Topics:
autoimmune diseases
,
diabetes mellitus, type 1
,
genetics
Diabetes July 1999, Vol.48, 1353-1358. doi:https://doi.org/10.2337/diabetes.48.7.1353
Insulin-induced insulin receptor substrate-1 degradation is mediated by the proteasome degradation pathway.
Diabetes July 1999, Vol.48, 1359-1364. doi:https://doi.org/10.2337/diabetes.48.7.1359
No correlation of plasma cell 1 overexpression with insulin resistance in diabetic rats and 3T3-L1 adipocytes.
H Sakoda; T Ogihara; M Anai; M Funaki; K Inukai; H Katagiri; Y Fukushima; Y Onishi; H Ono; Y Yazaki; M Kikuchi; Y Oka; T Asano
Topics:
adipocytes
,
insulin resistance
,
plasma cells
,
protein overexpression
,
rats
Diabetes July 1999, Vol.48, 1365-1371. doi:https://doi.org/10.2337/diabetes.48.7.1365
Activation of the sphingomyelinase/ceramide signal transduction pathway in insulin-secreting beta-cells: role in cytokine-induced beta-cell death.
Topics:
ceramides
,
cytokine
,
insulin
,
pancreatic beta cell
,
signal transduction pathways
Diabetes July 1999, Vol.48, 1372-1380. doi:https://doi.org/10.2337/diabetes.48.7.1372
Why do microencapsulated islet grafts fail in the absence of fibrotic overgrowth?
P De Vos; J F Van Straaten; A G Nieuwenhuizen; M de Groot; R J Ploeg; B J De Haan; R Van Schilfgaarde
Topics:
tissue transplants
Diabetes July 1999, Vol.48, 1381-1388. doi:https://doi.org/10.2337/diabetes.48.7.1381
Cow's milk formula feeding induces primary immunization to insulin in infants at genetic risk for type 1 diabetes.
O Vaarala; M Knip; J Paronen; A M Hämäläinen; P Muona; M Väätäinen; J Ilonen; O Simell; H K Akerblom
Topics:
cow's milk
,
diabetes mellitus, type 1
,
genetic risk
,
immunization
,
infant
Diabetes July 1999, Vol.48, 1389-1394. doi:https://doi.org/10.2337/diabetes.48.7.1389
Long-term elevation of free fatty acids leads to delayed processing of proinsulin and prohormone convertases 2 and 3 in the pancreatic beta-cell line MIN6.
Topics:
nonesterified fatty acids
,
pancreas
,
pancreatic beta cell
,
prohormone
,
proinsulin
Diabetes July 1999, Vol.48, 1395-1401. doi:https://doi.org/10.2337/diabetes.48.7.1395
Pancreatic beta-cell-to-beta-cell interactions are required for integrated responses to nutrient stimuli: enhanced Ca2+ and insulin secretory responses of MIN6 pseudoislets.
Topics:
calcium ions
,
insulin
,
nutrients
,
pancreas
Diabetes July 1999, Vol.48, 1402-1408. doi:https://doi.org/10.2337/diabetes.48.7.1402
Enhancing effects of long-term elevated glucose and palmitate on stored and secreted proinsulin-to-insulin ratios in human pancreatic islets.
Topics:
endocrine pancreas
,
hyperglycemia
,
insulin
,
palmitates
,
proinsulin
Diabetes July 1999, Vol.48, 1409-1414. doi:https://doi.org/10.2337/diabetes.48.7.1409
A novel N-aryl tyrosine activator of peroxisome proliferator-activated receptor-gamma reverses the diabetic phenotype of the Zucker diabetic fatty rat.
K K Brown; B R Henke; S G Blanchard; J E Cobb; R Mook; I Kaldor; S A Kliewer; J M Lehmann; J M Lenhard; W W Harrington; P J Novak; W Faison; J G Binz; M A Hashim; W O Oliver; H R Brown; D J Parks; K D Plunket; W Q Tong; J A Menius; K Adkison; S A Noble; T M Willson
Topics:
peroxisome
,
phenotype
,
transcriptional activation
,
tyrosine
Diabetes July 1999, Vol.48, 1415-1424. doi:https://doi.org/10.2337/diabetes.48.7.1415
Obesity-related phenotypes and the beta3-adrenoceptor gene variant in postmenopausal women.
A Tchernof; R D Starling; J D Walston; A R Shuldiner; R V Dvorak; K Silver; D E Matthews; E T Poehlman
Topics:
adrenergic receptor
,
genes
,
obesity
,
phenotype
,
postmenopause
Diabetes July 1999, Vol.48, 1425-1428. doi:https://doi.org/10.2337/diabetes.48.7.1425
Hypoglycemia per se stimulates sympathetic neural as well as adrenomedullary activity, but, unlike the adrenomedullary response, the forearm sympathetic neural response is not reduced after recent hypoglycemia.
Topics:
forearm
,
hypoglycemia
Diabetes July 1999, Vol.48, 1429-1436. doi:https://doi.org/10.2337/diabetes.48.7.1429
New concept for long-acting insulin: spontaneous conversion of an inactive modified insulin to the active hormone in circulation: 9-fluorenylmethoxycarbonyl derivative of insulin.
Topics:
hormones
,
insulin
,
long-acting insulin
Diabetes July 1999, Vol.48, 1437-1442. doi:https://doi.org/10.2337/diabetes.48.7.1437
Effects of glucose intolerance on myocardial function and collagen-linked glycation.
Topics:
collagen
,
glucose intolerance
,
glycation
,
myocardium
Diabetes July 1999, Vol.48, 1443-1447. doi:https://doi.org/10.2337/diabetes.48.7.1443
The thiazolidinedione rosiglitazone (BRL-49653) lowers blood pressure and protects against impairment of endothelial function in Zucker fatty rats.
Topics:
blood pressure
,
endothelium
,
rats
,
rosiglitazone
,
thiazolidinedione
Diabetes July 1999, Vol.48, 1448-1453. doi:https://doi.org/10.2337/diabetes.48.7.1448
Antibodies to oxidized LDL predict coronary artery disease in type 1 diabetes: a nested case-control study from the Pittsburgh Epidemiology of Diabetes Complications Study.
Topics:
antibodies
,
coronary arteriosclerosis
,
diabetes mellitus complications
,
diabetes mellitus, type 1
,
epidemiology
Diabetes July 1999, Vol.48, 1454-1458. doi:https://doi.org/10.2337/diabetes.48.7.1454
Functional characterization of the MODY1 gene mutations HNF4(R127W), HNF4(V255M), and HNF4(E276Q).
Topics:
mutation
,
dna
,
diabetes mellitus, type 2
,
glutamic acid
,
immunoprecipitation
Diabetes July 1999, Vol.48, 1459-1465. doi:https://doi.org/10.2337/diabetes.48.7.1459
Pro12Ala substitution in the peroxisome proliferator-activated receptor-gamma2 is not associated with type 2 diabetes.
Topics:
diabetes mellitus, type 2
,
peroxisome
Diabetes July 1999, Vol.48, 1466-1468. doi:https://doi.org/10.2337/diabetes.48.7.1466
The 3'-untranslated region polymorphism of the gene for skeletal muscle-specific glycogen-targeting subunit of protein phosphatase 1 in the type 2 diabetic Japanese population.
H Maegawa; K Shi; H Hidaka; N Iwai; Y Nishio; K Egawa; H Kojima; M Haneda; H Yasuda; Y Nakamura; M Kinoshita; R Kikkawa; A Kashiwagi
Topics:
genes
,
glycogen
,
polymorphism
,
protein phosphatase
Diabetes July 1999, Vol.48, 1469-1472. doi:https://doi.org/10.2337/diabetes.48.7.1469
Long-term survival and function of intrahepatic islet allografts in baboons treated with humanized anti-CD154.
N S Kenyon; L A Fernandez; R Lehmann; M Masetti; A Ranuncoli; M Chatzipetrou; G Iaria; D Han; J L Wagner; P Ruiz; M Berho; L Inverardi; R Alejandro; D H Mintz; A D Kirk; D M Harlan; L C Burkly; C Ricordi
Topics:
allografting
,
cd40 ligand
,
papio
Diabetes July 1999, Vol.48, 1473-1481. doi:https://doi.org/10.2337/diabetes.48.7.1473
Overexpression of uncoupling protein 2 inhibits glucose-stimulated insulin secretion from rat islets.
Topics:
glucose
,
insulin secretion
,
protein overexpression
,
uncoupling protein 2
Diabetes July 1999, Vol.48, 1482-1486. doi:https://doi.org/10.2337/diabetes.48.7.1482
Leptin restores euglycemia and normalizes glucose turnover in insulin-deficient diabetes in the rat.
Topics:
blood glucose normal
,
glucose
,
insulin
,
leptin
Diabetes July 1999, Vol.48, 1487-1492. doi:https://doi.org/10.2337/diabetes.48.7.1487
