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Volume 48, Issue 9

1 September 1999

ISSN 0012-1797

EISSN 1939-327X

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Onset of type 1 diabetes: a dynamical instability.

B Freiesleben De Blasio; P Bak; F Pociot; A E Karlsen; J Nerup

Abstract

View articletitled, Onset of type 1 diabetes: a dynamical instability.

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Topics: diabetes mellitus, type 1

Diabetes September 1999, Vol.48, 1677-1685. doi:https://doi.org/10.2337/diabetes.48.9.1677

Identification of the docked granule pool responsible for the first phase of glucose-stimulated insulin secretion.

S Daniel; M Noda; S G Straub; G W Sharp

Abstract

View articletitled, Identification of the docked granule pool responsible for the first phase of glucose-stimulated insulin secretion.

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Topics: glucose , granules , insulin secretion

Diabetes September 1999, Vol.48, 1686-1690. doi:https://doi.org/10.2337/diabetes.48.9.1686

Long-term regulation of lipolysis and hormone-sensitive lipase by insulin and glucose.

L M Botion; A Green

Abstract

View articletitled, Long-term regulation of lipolysis and hormone-sensitive lipase by insulin and glucose.

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Topics: glucose , insulin , lipolysis , sterol esterase

Diabetes September 1999, Vol.48, 1691-1697. doi:https://doi.org/10.2337/diabetes.48.9.1691

Structural model of human glucokinase in complex with glucose and ATP: implications for the mutants that cause hypo- and hyperglycemia.

B Mahalingam; A Cuesta-Munoz; E A Davis; F M Matschinsky; R W Harrison; I T Weber

Abstract

View articletitled, Structural model of human glucokinase in complex with glucose and ATP: implications for the mutants that cause hypo- and hyperglycemia.

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Topics: glucokinase , glucose , hyperglycemia , models, structural

Diabetes September 1999, Vol.48, 1698-1705. doi:https://doi.org/10.2337/diabetes.48.9.1698

Role of the sympathetic nervous system and insulin in enhancing glucose uptake in peripheral tissues after intrahypothalamic injection of leptin in rats.

M S Haque; Y Minokoshi; M Hamai; M Iwai; M Horiuchi; T Shimazu

Abstract

View articletitled, Role of the sympathetic nervous system and insulin in enhancing glucose uptake in peripheral tissues after intrahypothalamic injection of leptin in rats.

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Topics: glucose uptake , insulin , leptin , rats , sympathetic nervous system

Diabetes September 1999, Vol.48, 1706-1712. doi:https://doi.org/10.2337/diabetes.48.9.1706

Neonatal porcine islet cells induce human CD4+, but not CD8+, lymphocyte proliferation and resist cell-mediated cytolytic injury in vitro.

A G Murray; R C Nelson; G R Rayat; J F Elliott; G S Korbutt

Abstract

View articletitled, Neonatal porcine islet cells induce human CD4+, but not CD8+, lymphocyte proliferation and resist cell-mediated cytolytic injury in vitro.

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Topics: cd8-positive t-lymphocytes , endocrine pancreas , newborn , suidae

Diabetes September 1999, Vol.48, 1713-1719. doi:https://doi.org/10.2337/diabetes.48.9.1713

Insulin B-chain reactive CD4+ regulatory T-cells induced by oral insulin treatment protect from type 1 diabetes by blocking the cytokine secretion and pancreatic infiltration of diabetogenic effector T-cells.

I Bergerot; G A Arreaza; M J Cameron; M D Burdick; R M Strieter; S W Chensue; S Chakrabarti; T L Delovitch

Abstract

View articletitled, Insulin B-chain reactive CD4+ regulatory T-cells induced by oral insulin treatment protect from type 1 diabetes by blocking the cytokine secretion and pancreatic infiltration of diabetogenic effector T-cells.

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Topics: bodily secretions , cytokine , diabetes mellitus, type 1 , insulin , pancreas

Diabetes September 1999, Vol.48, 1720-1729. doi:https://doi.org/10.2337/diabetes.48.9.1720

Adenoviral gene transfer of the interleukin-1 receptor antagonist protein to human islets prevents IL-1beta-induced beta-cell impairment and activation of islet cell apoptosis in vitro.

N Giannoukakis; W A Rudert; S C Ghivizzani; A Gambotto; C Ricordi; M Trucco; P D Robbins

Abstract

View articletitled, Adenoviral gene transfer of the interleukin-1 receptor antagonist protein to human islets prevents IL-1beta-induced beta-cell impairment and activation of islet cell apoptosis in vitro.

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Topics: adenoviruses , apoptosis , endocrine pancreas , gene transfer techniques , interleukin-1 receptor antagonists

Diabetes September 1999, Vol.48, 1730-1736. doi:https://doi.org/10.2337/diabetes.48.9.1730

Normoglycemia and preserved insulin secretory reserve in diabetic patients 10-18 years after pancreas transplantation.

R P Robertson; D E Sutherland; K J Lanz

Abstract

View articletitled, Normoglycemia and preserved insulin secretory reserve in diabetic patients 10-18 years after pancreas transplantation.

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Topics: insulin , pancreas transplantation

Diabetes September 1999, Vol.48, 1737-1740. doi:https://doi.org/10.2337/diabetes.48.9.1737

Corticotropin-releasing factor modulation of Ca2+ influx in rat pancreatic beta-cells.

T Kanno; S Suga; K Nakano; N Kamimura; M Wakui

Abstract

View articletitled, Corticotropin-releasing factor modulation of Ca2+ influx in rat pancreatic beta-cells.

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Topics: calcium ions , corticotropin-releasing hormone , pancreas

Diabetes September 1999, Vol.48, 1741-1746. doi:https://doi.org/10.2337/diabetes.48.9.1741

Glucose-fatty acid cycle to inhibit glucose utilization and oxidation is not operative in fatty acid-cultured islets.

Y Q Liu; K Tornheim; J L Leahy

Abstract

View articletitled, Glucose-fatty acid cycle to inhibit glucose utilization and oxidation is not operative in fatty acid-cultured islets.

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Topics: glucose , oxidation

Diabetes September 1999, Vol.48, 1747-1753. doi:https://doi.org/10.2337/diabetes.48.9.1747

A defect late in stimulus-secretion coupling impairs insulin secretion in Goto-Kakizaki diabetic rats.

S A Metz; M Meredith; J Vadakekalam; M E Rabaglia; A Kowluru

Abstract

View articletitled, A defect late in stimulus-secretion coupling impairs insulin secretion in Goto-Kakizaki diabetic rats.

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Topics: bodily secretions , insulin secretion , rats

Diabetes September 1999, Vol.48, 1754-1762. doi:https://doi.org/10.2337/diabetes.48.9.1754

Hypothalamic glucose sensor: similarities to and differences from pancreatic beta-cell mechanisms.

X J Yang; L M Kow; T Funabashi; C V Mobbs

Abstract

View articletitled, Hypothalamic glucose sensor: similarities to and differences from pancreatic beta-cell mechanisms.

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Topics: glucose , hypothalamus , pancreas , pancreatic beta cell , sensor

Diabetes September 1999, Vol.48, 1763-1772. doi:https://doi.org/10.2337/diabetes.48.9.1763

Expression of alpha-1 proteinase inhibitor in human islet microvascular endothelial cells.

J Lou; F Triponez; J Oberholzer; H Wang; D Yu; L Buhler; N Cretin; G Mentha; C B Wollheim; P Morel

Abstract

View articletitled, Expression of alpha-1 proteinase inhibitor in human islet microvascular endothelial cells.

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Topics: alpha 1-antitrypsin , endothelial cells

Diabetes September 1999, Vol.48, 1773-1778. doi:https://doi.org/10.2337/diabetes.48.9.1773

Comparison of tests of beta-cell function across a range of glucose tolerance from normal to diabetes.

M P Hermans; J C Levy; R J Morris; R C Turner

Abstract

View articletitled, Comparison of tests of beta-cell function across a range of glucose tolerance from normal to diabetes.

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Topics: glucose tolerance , pancreatic beta cell , insulin

Diabetes September 1999, Vol.48, 1779-1786. doi:https://doi.org/10.2337/diabetes.48.9.1779

Sympathetic activation of leptin via the ventromedial hypothalamus: leptin-induced increase in catecholamine secretion.

N Satoh; Y Ogawa; G Katsuura; Y Numata; T Tsuji; M Hayase; K Ebihara; H Masuzaki; K Hosoda; Y Yoshimasa; K Nakao

Abstract

View articletitled, Sympathetic activation of leptin via the ventromedial hypothalamus: leptin-induced increase in catecholamine secretion.

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Topics: bodily secretions , catecholamines , hypothalamus , leptin

Diabetes September 1999, Vol.48, 1787-1793. doi:https://doi.org/10.2337/diabetes.48.9.1787

T-1095, an inhibitor of renal Na+-glucose cotransporters, may provide a novel approach to treating diabetes.

A Oku; K Ueta; K Arakawa; T Ishihara; M Nawano; Y Kuronuma; M Matsumoto; A Saito; K Tsujihara; M Anai; T Asano; Y Kanai; H Endou

Abstract

View articletitled, T-1095, an inhibitor of renal Na+-glucose cotransporters, may provide a novel approach to treating diabetes.

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Topics: glucose , kidney

Diabetes September 1999, Vol.48, 1794-1800. doi:https://doi.org/10.2337/diabetes.48.9.1794

Altered hypothalamic function in response to glucose ingestion in obese humans.

M Matsuda; Y Liu; S Mahankali; Y Pu; A Mahankali; J Wang; R A DeFronzo; P T Fox; J H Gao

Abstract

View articletitled, Altered hypothalamic function in response to glucose ingestion in obese humans.

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Topics: glucose , hypothalamus , ingestion , obesity

Diabetes September 1999, Vol.48, 1801-1806. doi:https://doi.org/10.2337/diabetes.48.9.1801

Impaired glucose transport and insulin receptor tyrosine phosphorylation in skeletal muscle from obese women with gestational diabetes.

J E Friedman; T Ishizuka; J Shao; L Huston; T Highman; P Catalano

Abstract

View articletitled, Impaired glucose transport and insulin receptor tyrosine phosphorylation in skeletal muscle from obese women with gestational diabetes.

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Topics: gestational diabetes , glucose transport , insulin receptor , obesity , phosphorylation

Diabetes September 1999, Vol.48, 1807-1814. doi:https://doi.org/10.2337/diabetes.48.9.1807

Nitric oxide synthase inhibition reduces leg glucose uptake but not blood flow during dynamic exercise in humans.

S J Bradley; B A Kingwell; G K McConell

Abstract

View articletitled, Nitric oxide synthase inhibition reduces leg glucose uptake but not blood flow during dynamic exercise in humans.

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Topics: glucose uptake , leg , nitric oxide synthase , vascular flow

Diabetes September 1999, Vol.48, 1815-1821. doi:https://doi.org/10.2337/diabetes.48.9.1815

Increased glucose metabolism and insulin sensitivity in transgenic skinny mice overexpressing leptin.

Y Ogawa; H Masuzaki; K Hosoda; M Aizawa-Abe; J Suga; M Suda; K Ebihara; H Iwai; N Matsuoka; N Satoh; H Odaka; H Kasuga; Y Fujisawa; G Inoue; H Nishimura; Y Yoshimasa; K Nakao

Abstract

View articletitled, Increased glucose metabolism and insulin sensitivity in transgenic skinny mice overexpressing leptin.

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Topics: animals, transgenic , glucose metabolism , insulin sensitivity , leptin , mice

Diabetes September 1999, Vol.48, 1822-1829. doi:https://doi.org/10.2337/diabetes.48.9.1822

Improvement in insulin resistance and the restoration of reduced phosphodiesterase 3B gene expression by pioglitazone in adipose tissue of obese diabetic KKAy mice.

Y Tang; H Osawa; H Onuma; T Nishimiya; M Ochi; H Makino

Abstract

View articletitled, Improvement in insulin resistance and the restoration of reduced phosphodiesterase 3B gene expression by pioglitazone in adipose tissue of obese diabetic KKAy mice.

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Topics: adipose tissue , gene expression , insulin resistance , mice , obesity

Diabetes September 1999, Vol.48, 1830-1835. doi:https://doi.org/10.2337/diabetes.48.9.1830

Overnight lowering of free fatty acids with Acipimox improves insulin resistance and glucose tolerance in obese diabetic and nondiabetic subjects.

A T Santomauro; G Boden; M E Silva; D M Rocha; R F Santos; M J Ursich; P G Strassmann; B L Wajchenberg

Abstract

View articletitled, Overnight lowering of free fatty acids with Acipimox improves insulin resistance and glucose tolerance in obese diabetic and nondiabetic subjects.

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Topics: glucose tolerance , insulin resistance , nonesterified fatty acids , obesity

Diabetes September 1999, Vol.48, 1836-1841. doi:https://doi.org/10.2337/diabetes.48.9.1836

Autoantibody against N(epsilon)-(carboxymethyl)lysine: an advanced glycation end product of the Maillard reaction.

R Shibayama; N Araki; R Nagai; S Horiuchi

Abstract

View articletitled, Autoantibody against N(epsilon)-(carboxymethyl)lysine: an advanced glycation end product of the Maillard reaction.

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Topics: autoantibodies , glycosylation end products, advanced , lysine , maillard reaction

Diabetes September 1999, Vol.48, 1842-1849. doi:https://doi.org/10.2337/diabetes.48.9.1842

Hyperketonemia can increase lipid peroxidation and lower glutathione levels in human erythrocytes in vitro and in type 1 diabetic patients.

S K Jain; R McVie

Abstract

View articletitled, Hyperketonemia can increase lipid peroxidation and lower glutathione levels in human erythrocytes in vitro and in type 1 diabetic patients.

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Topics: erythrocytes , glutathione , lipid peroxidation

Diabetes September 1999, Vol.48, 1850-1855. doi:https://doi.org/10.2337/diabetes.48.9.1850

Microvascular and macrovascular reactivity is reduced in subjects at risk for type 2 diabetes.

A E Caballero; S Arora; R Saouaf; S C Lim; P Smakowski; J Y Park; G L King; F W LoGerfo; E S Horton; A Veves

Abstract

View articletitled, Microvascular and macrovascular reactivity is reduced in subjects at risk for type 2 diabetes.

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Topics: diabetes mellitus, type 2

Diabetes September 1999, Vol.48, 1856-1862. doi:https://doi.org/10.2337/diabetes.48.9.1856

A quantitative trait locus influencing BMI maps to the region of the beta-3 adrenergic receptor.

B D Mitchell; S A Cole; A G Comuzzie; L Almasy; J Blangero; J W MacCluer; J E Hixson

Abstract

View articletitled, A quantitative trait locus influencing BMI maps to the region of the beta-3 adrenergic receptor.

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Topics: adrenergic receptor , body mass index procedure , maps , quantitative trait loci

Diabetes September 1999, Vol.48, 1863-1867. doi:https://doi.org/10.2337/diabetes.48.9.1863

Variants of the insulin receptor substrate-1 and fatty acid binding protein 2 genes and the risk of type 2 diabetes, obesity, and hyperinsulinemia in African-Americans: the Atherosclerosis Risk in Communities Study.

H H Lei; J Coresh; A R Shuldiner; E Boerwinkle; F L Brancati

Abstract

View articletitled, Variants of the insulin receptor substrate-1 and fatty acid binding protein 2 genes and the risk of type 2 diabetes, obesity, and hyperinsulinemia in African-Americans: the Atherosclerosis Risk in Communities Study.

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Topics: aric trial , diabetes mellitus, type 2 , fatty acid-binding proteins , genes , hyperinsulinism

Diabetes September 1999, Vol.48, 1868-1872. doi:https://doi.org/10.2337/diabetes.48.9.1868

Isolation, characterization, and chromosomal localization of the human ENSA gene that encodes alpha-endosulfine, a regulator of beta-cell K(ATP) channels.

L Héron; A Virsolvy; F Apiou; A Le Cam; D Bataille

Abstract

View articletitled, Isolation, characterization, and chromosomal localization of the human ENSA gene that encodes alpha-endosulfine, a regulator of beta-cell K(ATP) channels.

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Topics: chromosomes , genes , pancreatic beta cell

Diabetes September 1999, Vol.48, 1873-1876. doi:https://doi.org/10.2337/diabetes.48.9.1873

Human insulin receptor substrate-2: gene organization and promoter characterization.

L Vassen; W Wegrzyn; L Klein-Hitpass

Abstract

View articletitled, Human insulin receptor substrate-2: gene organization and promoter characterization.

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Topics: gene organization , insulin receptor

Diabetes September 1999, Vol.48, 1877-1880. doi:https://doi.org/10.2337/diabetes.48.9.1877

A polymorphism (K121Q) of the human glycoprotein PC-1 gene coding region is strongly associated with insulin resistance.

A Pizzuti; L Frittitta; A Argiolas; R Baratta; I D Goldfine; M Bozzali; T Ercolino; G Scarlato; L Iacoviello; R Vigneri; V Tassi; V Trischitta

Abstract

View articletitled, A polymorphism (K121Q) of the human glycoprotein PC-1 gene coding region is strongly associated with insulin resistance.

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Topics: genes , glycoproteins , insulin resistance , open reading frames , polymorphism

Diabetes September 1999, Vol.48, 1881-1884. doi:https://doi.org/10.2337/diabetes.48.9.1881

Conservation of an insulin response unit between mouse and human glucose-6-phosphatase catalytic subunit gene promoters: transcription factor FKHR binds the insulin response sequence.

J E Ayala; R S Streeper; J S Desgrosellier; S K Durham; A Suwanichkul; C A Svitek; J K Goldman; F G Barr; D R Powell; R M O'Brien

Abstract

View articletitled, Conservation of an insulin response unit between mouse and human glucose-6-phosphatase catalytic subunit gene promoters: transcription factor FKHR binds the insulin response sequence.

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Topics: binding (molecular function) , catalytic domain , genes , glucose-6-phosphatase , insulin

Diabetes September 1999, Vol.48, 1885-1889. doi:https://doi.org/10.2337/diabetes.48.9.1885

Genetic and physiologic analysis of the role of uncoupling protein 3 in human energy homeostasis.

Abstract

View articletitled, Genetic and physiologic analysis of the role of uncoupling protein 3 in human energy homeostasis.

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Topics: genetics , homeostasis , uncoupling protein 3

Diabetes September 1999, Vol.48, 1890-1895. doi:https://doi.org/10.2337/diabetes.48.9.1890

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