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Triggering and amplifying pathways of regulation of insulin secretion by glucose.
Diabetes November 2000, Vol.49, 1751-1760. doi:https://doi.org/10.2337/diabetes.49.11.1751
Acyl-CoA inhibition of hexokinase in rat and human skeletal muscle is a potential mechanism of lipid-induced insulin resistance.
Diabetes November 2000, Vol.49, 1761-1765. doi:https://doi.org/10.2337/diabetes.49.11.1761
Beacon: a novel gene involved in the regulation of energy balance.
G R Collier; J S McMillan; K Windmill; K Walder; J Tenne-Brown; A de Silva; J Trevaskis; S Jones; G J Morton; S Lee; G Augert; A Civitarese; P Z Zimmet
Diabetes November 2000, Vol.49, 1766-1771. doi:https://doi.org/10.2337/diabetes.49.11.1766
Sustained activation of insulin receptors internalized in GLUT4 vesicles of insulin-stimulated skeletal muscle.
Diabetes November 2000, Vol.49, 1772-1782. doi:https://doi.org/10.2337/diabetes.49.11.1772
Activation of p38 mitogen-activated protein kinase alpha and beta by insulin and contraction in rat skeletal muscle: potential role in the stimulation of glucose transport.
R Somwar; M Perreault; S Kapur; C Taha; G Sweeney; T Ramlal; D Y Kim; J Keen; C H Côte; A Klip; A Marette
Diabetes November 2000, Vol.49, 1794-1800. doi:https://doi.org/10.2337/diabetes.49.11.1794
Virus-induced autoimmune diabetes: most beta-cells die through inflammatory cytokines and not perforin from autoreactive (anti-viral) cytotoxic T-lymphocytes.
S Seewaldt; H E Thomas; M Ejrnaes; U Christen; T Wolfe; E Rodrigo; B Coon; B Michelsen; T W Kay; M G von Herrath
Diabetes November 2000, Vol.49, 1801-1809. doi:https://doi.org/10.2337/diabetes.49.11.1801
Testicular sertoli cells protect islet beta-cells from autoimmune destruction in NOD mice by a transforming growth factor-beta1-dependent mechanism.
Diabetes November 2000, Vol.49, 1810-1818. doi:https://doi.org/10.2337/diabetes.49.11.1810
Cytokine- or chemically derived nitric oxide alters the expression of proteins detected by two-dimensional gel electrophoresis in neonatal rat islets of Langerhans.
N E John; H U Andersen; S J Fey; P M Larsen; P Roepstorff; M R Larsen; F Pociot; A E Karlsen; J Nerup; I C Green; T Mandrup-Poulsen
Diabetes November 2000, Vol.49, 1819-1829. doi:https://doi.org/10.2337/diabetes.49.11.1819
PIP2 and ATP cooperatively prevent cytosolic Ca2+-induced modification of ATP-sensitive K+ channels in rat pancreatic beta-cells.
Diabetes November 2000, Vol.49, 1830-1839. doi:https://doi.org/10.2337/diabetes.49.11.1830
Glucose-induced [Ca2+]i abnormalities in human pancreatic islets: important role of overstimulation.
Diabetes November 2000, Vol.49, 1840-1848. doi:https://doi.org/10.2337/diabetes.49.11.1840
Poly(ADP-ribose) polymerase facilitates the repair of N-methylpurines in mitochondrial DNA.
Diabetes November 2000, Vol.49, 1849-1855. doi:https://doi.org/10.2337/diabetes.49.11.1849
Impaired insulin secretion and increased insulin sensitivity in familial maturity-onset diabetes of the young 4 (insulin promoter factor 1 gene).
A R Clocquet; J M Egan; D A Stoffers; D C Muller; L Wideman; G A Chin; W L Clarke; J B Hanks; J F Habener; D Elahi
Diabetes November 2000, Vol.49, 1856-1864. doi:https://doi.org/10.2337/diabetes.49.11.1856
Repeated 2-deoxy-D-glucose-induced glucoprivation attenuates Fos expression and glucoregulatory responses during subsequent glucoprivation.
Diabetes November 2000, Vol.49, 1865-1874. doi:https://doi.org/10.2337/diabetes.49.11.1865
The subcutaneous lipolytic response to regional neural stimulation is reduced in obese women.
Diabetes November 2000, Vol.49, 1875-1879. doi:https://doi.org/10.2337/diabetes.49.11.1875
Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia.
N Kubota; K Tobe; Y Terauchi; K Eto; T Yamauchi; R Suzuki; Y Tsubamoto; K Komeda; R Nakano; H Miki; S Satoh; H Sekihara; S Sciacchitano; M Lesniak; S Aizawa; R Nagai; S Kimura; Y Akanuma; S I Taylor; T Kadowaki
Diabetes November 2000, Vol.49, 1880-1889. doi:https://doi.org/10.2337/diabetes.49.11.1880
Unlike leptin, ciliary neurotrophic factor does not reverse the starvation-induced changes of serum corticosterone and hypothalamic neuropeptide levels but induces expression of hypothalamic inhibitors of leptin signaling.
Diabetes November 2000, Vol.49, 1890-1896. doi:https://doi.org/10.2337/diabetes.49.11.1890
Effects of differing durations of antecedent hypoglycemia on counterregulatory responses to subsequent hypoglycemia in normal humans.
Diabetes November 2000, Vol.49, 1897-1903. doi:https://doi.org/10.2337/diabetes.49.11.1897
Acute impairment of insulin-mediated capillary recruitment and glucose uptake in rat skeletal muscle in vivo by TNF-alpha.
Diabetes November 2000, Vol.49, 1904-1909. doi:https://doi.org/10.2337/diabetes.49.11.1904
Lack of responses to a beta3-adrenergic agonist in lipoatrophic A-ZIP/F-1 mice.
Diabetes November 2000, Vol.49, 1910-1916. doi:https://doi.org/10.2337/diabetes.49.11.1910
Adrenalectomy reverses obese phenotype and restores hypothalamic melanocortin tone in leptin-deficient ob/ob mice.
Diabetes November 2000, Vol.49, 1917-1923. doi:https://doi.org/10.2337/diabetes.49.11.1917
Dehydroepiandrosterone prevents oxidative injury induced by transient ischemia/reperfusion in the brain of diabetic rats.
Diabetes November 2000, Vol.49, 1924-1931. doi:https://doi.org/10.2337/diabetes.49.11.1924
Diabetic peripheral neuropathy: evidence for apoptosis and associated mitochondrial dysfunction.
Diabetes November 2000, Vol.49, 1932-1938. doi:https://doi.org/10.2337/diabetes.49.11.1932
High glucose level and free fatty acid stimulate reactive oxygen species production through protein kinase C--dependent activation of NAD(P)H oxidase in cultured vascular cells.
T Inoguchi; P Li; F Umeda; H Y Yu; M Kakimoto; M Imamura; T Aoki; T Etoh; T Hashimoto; M Naruse; H Sano; H Utsumi; H Nawata
Diabetes November 2000, Vol.49, 1939-1945. doi:https://doi.org/10.2337/diabetes.49.11.1939
Genetic obesity unmasks nonlinear interactions between murine type 2 diabetes susceptibility loci.
Diabetes November 2000, Vol.49, 1946-1954. doi:https://doi.org/10.2337/diabetes.49.11.1946
beta-cell transcription factors and diabetes: no evidence for diabetes-associated mutations in the gene encoding the basic helix-loop-helix transcription factor neurogenic differentiation 4 (NEUROD4) in Japanese patients with MODY.
Y Horikawa; Y Horikawa; N J Cox; N Iwasaki; M Ogata; Y Iwamoto; V Schwitzgebel; M S German; G I Bell
Diabetes November 2000, Vol.49, 1955-1957. doi:https://doi.org/10.2337/diabetes.49.11.1955
Lamin A/C gene: sex-determined expression of mutations in Dunnigan-type familial partial lipodystrophy and absence of coding mutations in congenital and acquired generalized lipoatrophy.
C Vigouroux; J Magré; M C Vantyghem; C Bourut; O Lascols; S Shackleton; D J Lloyd; B Guerci; G Padova; P Valensi; A Grimaldi; R Piquemal; P Touraine; R C Trembath; J Capeau
Diabetes November 2000, Vol.49, 1958-1962. doi:https://doi.org/10.2337/diabetes.49.11.1958