Skip Nav Destination

Issues

Select Decade

Select Year

Issue

Volume 49, Issue 11

1 November 2000

ISSN 0012-1797

EISSN 1939-327X

Search within issue:

Search within issue

Triggering and amplifying pathways of regulation of insulin secretion by glucose.

J C Henquin

Abstract

View articletitled, Triggering and amplifying pathways of regulation of insulin secretion by glucose.

Click here to open pdf in another window PDF for

Topics: glucose , regulation of insulin secretion

Diabetes November 2000, Vol.49, 1751-1760. doi:https://doi.org/10.2337/diabetes.49.11.1751

Acyl-CoA inhibition of hexokinase in rat and human skeletal muscle is a potential mechanism of lipid-induced insulin resistance.

A L Thompson; G J Cooney

Abstract

View articletitled, Acyl-CoA inhibition of hexokinase in rat and human skeletal muscle is a potential mechanism of lipid-induced insulin resistance.

Topics: acyl coenzyme a , hexokinase , insulin resistance , lipids , skeletal muscles

Diabetes November 2000, Vol.49, 1761-1765. doi:https://doi.org/10.2337/diabetes.49.11.1761

Beacon: a novel gene involved in the regulation of energy balance.

G R Collier; J S McMillan; K Windmill; K Walder; J Tenne-Brown; A de Silva; J Trevaskis; S Jones; G J Morton; S Lee; G Augert; A Civitarese; P Z Zimmet

Abstract

View articletitled, Beacon: a novel gene involved in the regulation of energy balance.

Topics: energy balance , genes , animal model , obesity , weight gain

Diabetes November 2000, Vol.49, 1766-1771. doi:https://doi.org/10.2337/diabetes.49.11.1766

Sustained activation of insulin receptors internalized in GLUT4 vesicles of insulin-stimulated skeletal muscle.

L Dombrowski; R Faure; A Marette

Abstract

View articletitled, Sustained activation of insulin receptors internalized in GLUT4 vesicles of insulin-stimulated skeletal muscle.

Click here to open pdf in another window PDF for

Topics: insulin , insulin receptor , skeletal muscles , vesicle

Diabetes November 2000, Vol.49, 1772-1782. doi:https://doi.org/10.2337/diabetes.49.11.1772

Stimulation of MAPK cascades by insulin and osmotic shock: lack of an involvement of p38 mitogen-activated protein kinase in glucose transport in 3T3-L1 adipocytes.

A G Kayali; D A Austin; N J Webster

Abstract

View articletitled, Stimulation of MAPK cascades by insulin and osmotic shock: lack of an involvement of p38 mitogen-activated protein kinase in glucose transport in 3T3-L1 adipocytes.

Click here to open pdf in another window PDF for

Topics: adipocytes , glucose transport , insulin , map kinase cascade , mitogen-activated protein kinases

Diabetes November 2000, Vol.49, 1783-1793. doi:https://doi.org/10.2337/diabetes.49.11.1783

Activation of p38 mitogen-activated protein kinase alpha and beta by insulin and contraction in rat skeletal muscle: potential role in the stimulation of glucose transport.

R Somwar; M Perreault; S Kapur; C Taha; G Sweeney; T Ramlal; D Y Kim; J Keen; C H Côte; A Klip; A Marette

Abstract

View articletitled, Activation of p38 mitogen-activated protein kinase alpha and beta by insulin and contraction in rat skeletal muscle: potential role in the stimulation of glucose transport.

Click here to open pdf in another window PDF for

Topics: glucose transport , insulin , mitogen-activated protein kinases , skeletal muscles

Diabetes November 2000, Vol.49, 1794-1800. doi:https://doi.org/10.2337/diabetes.49.11.1794

Virus-induced autoimmune diabetes: most beta-cells die through inflammatory cytokines and not perforin from autoreactive (anti-viral) cytotoxic T-lymphocytes.

S Seewaldt; H E Thomas; M Ejrnaes; U Christen; T Wolfe; E Rodrigo; B Coon; B Michelsen; T W Kay; M G von Herrath

Abstract

View articletitled, Virus-induced autoimmune diabetes: most beta-cells die through inflammatory cytokines and not perforin from autoreactive (anti-viral) cytotoxic T-lymphocytes.

Click here to open pdf in another window PDF for

Topics: autoimmunity , cytokine , death , perforin , t-lymphocytes, cytotoxic

Diabetes November 2000, Vol.49, 1801-1809. doi:https://doi.org/10.2337/diabetes.49.11.1801

Testicular sertoli cells protect islet beta-cells from autoimmune destruction in NOD mice by a transforming growth factor-beta1-dependent mechanism.

W Suarez-Pinzon; G S Korbutt; R Power; J Hooton; R V Rajotte; A Rabinovitch

Abstract

View articletitled, Testicular sertoli cells protect islet beta-cells from autoimmune destruction in NOD mice by a transforming growth factor-beta1-dependent mechanism.

Click here to open pdf in another window PDF for

Topics: autoimmunity , cd29 antigen , mice, inbred nod , sertoli cell

Diabetes November 2000, Vol.49, 1810-1818. doi:https://doi.org/10.2337/diabetes.49.11.1810

Cytokine- or chemically derived nitric oxide alters the expression of proteins detected by two-dimensional gel electrophoresis in neonatal rat islets of Langerhans.

N E John; H U Andersen; S J Fey; P M Larsen; P Roepstorff; M R Larsen; F Pociot; A E Karlsen; J Nerup; I C Green; T Mandrup-Poulsen

Abstract

View articletitled, Cytokine- or chemically derived nitric oxide alters the expression of proteins detected by two-dimensional gel electrophoresis in neonatal rat islets of Langerhans.

Click here to open pdf in another window PDF for

Topics: cytokine , electrophoresis, gel, two-dimensional , endocrine pancreas , newborn , nitric oxide

Diabetes November 2000, Vol.49, 1819-1829. doi:https://doi.org/10.2337/diabetes.49.11.1819

PIP2 and ATP cooperatively prevent cytosolic Ca2+-induced modification of ATP-sensitive K+ channels in rat pancreatic beta-cells.

N Koriyama; M Kakei; M Nakazaki; K Yaekura; K Ichinari; Q Gong; S Morimitsu; T Yada; C Tei

Abstract

View articletitled, PIP2 and ATP cooperatively prevent cytosolic Ca2+-induced modification of ATP-sensitive K+ channels in rat pancreatic beta-cells.

Click here to open pdf in another window PDF for

Topics: calcium ions , cytosol , pancreas , phosphatidylinositol 4,5-diphosphate

Diabetes November 2000, Vol.49, 1830-1839. doi:https://doi.org/10.2337/diabetes.49.11.1830

Glucose-induced [Ca2+]i abnormalities in human pancreatic islets: important role of overstimulation.

A Björklund; A Lansner; V E Grill

Abstract

View articletitled, Glucose-induced [Ca2+]i abnormalities in human pancreatic islets: important role of overstimulation.

Click here to open pdf in another window PDF for

Topics: calcium ions , endocrine pancreas , glucose

Diabetes November 2000, Vol.49, 1840-1848. doi:https://doi.org/10.2337/diabetes.49.11.1840

Poly(ADP-ribose) polymerase facilitates the repair of N-methylpurines in mitochondrial DNA.

N Druzhyna; M E Smulson; S P LeDoux; G L Wilson

Abstract

View articletitled, Poly(ADP-ribose) polymerase facilitates the repair of N-methylpurines in mitochondrial DNA.

Click here to open pdf in another window PDF for

Topics: adenosine diphosphate ribose , dna, mitochondrial

Diabetes November 2000, Vol.49, 1849-1855. doi:https://doi.org/10.2337/diabetes.49.11.1849

Impaired insulin secretion and increased insulin sensitivity in familial maturity-onset diabetes of the young 4 (insulin promoter factor 1 gene).

A R Clocquet; J M Egan; D A Stoffers; D C Muller; L Wideman; G A Chin; W L Clarke; J B Hanks; J F Habener; D Elahi

Abstract

View articletitled, Impaired insulin secretion and increased insulin sensitivity in familial maturity-onset diabetes of the young 4 (insulin promoter factor 1 gene).

Click here to open pdf in another window PDF for

Topics: fibrinogen , genes , insulin , insulin secretion, impaired , insulin sensitivity

Diabetes November 2000, Vol.49, 1856-1864. doi:https://doi.org/10.2337/diabetes.49.11.1856

Repeated 2-deoxy-D-glucose-induced glucoprivation attenuates Fos expression and glucoregulatory responses during subsequent glucoprivation.

N M Sanders; S Ritter

Abstract

View articletitled, Repeated 2-deoxy-D-glucose-induced glucoprivation attenuates Fos expression and glucoregulatory responses during subsequent glucoprivation.

Click here to open pdf in another window PDF for

Topics: glucose

Diabetes November 2000, Vol.49, 1865-1874. doi:https://doi.org/10.2337/diabetes.49.11.1865

The subcutaneous lipolytic response to regional neural stimulation is reduced in obese women.

C Dodt; P Lönnroth; H L Fehm; M Elam

Abstract

View articletitled, The subcutaneous lipolytic response to regional neural stimulation is reduced in obese women.

Click here to open pdf in another window PDF for

Topics: obesity

Diabetes November 2000, Vol.49, 1875-1879. doi:https://doi.org/10.2337/diabetes.49.11.1875

Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia.

Abstract

View articletitled, Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia.

Click here to open pdf in another window PDF for

Topics: diabetes mellitus, type 2 , hyperplasia , insulin resistance , irs2 protein, human , liver

Diabetes November 2000, Vol.49, 1880-1889. doi:https://doi.org/10.2337/diabetes.49.11.1880

Unlike leptin, ciliary neurotrophic factor does not reverse the starvation-induced changes of serum corticosterone and hypothalamic neuropeptide levels but induces expression of hypothalamic inhibitors of leptin signaling.

M Ziotopoulou; D M Erani; S M Hileman; C Bjørbaek; C S Mantzoros

Abstract

View articletitled, Unlike leptin, ciliary neurotrophic factor does not reverse the starvation-induced changes of serum corticosterone and hypothalamic neuropeptide levels but induces expression of hypothalamic inhibitors of leptin signaling.

Click here to open pdf in another window PDF for

Topics: ciliary neurotrophic factor , corticosterone , hypothalamus , leptin , neuropeptides

Diabetes November 2000, Vol.49, 1890-1896. doi:https://doi.org/10.2337/diabetes.49.11.1890

Effects of differing durations of antecedent hypoglycemia on counterregulatory responses to subsequent hypoglycemia in normal humans.

S N Davis; S Mann; P Galassetti; R A Neill; D Tate; A C Ertl; F Costa

Abstract

View articletitled, Effects of differing durations of antecedent hypoglycemia on counterregulatory responses to subsequent hypoglycemia in normal humans.

Click here to open pdf in another window PDF for

Topics: hypoglycemia

Diabetes November 2000, Vol.49, 1897-1903. doi:https://doi.org/10.2337/diabetes.49.11.1897

Acute impairment of insulin-mediated capillary recruitment and glucose uptake in rat skeletal muscle in vivo by TNF-alpha.

J M Youd; S Rattigan; M G Clark

Abstract

View articletitled, Acute impairment of insulin-mediated capillary recruitment and glucose uptake in rat skeletal muscle in vivo by TNF-alpha.

Click here to open pdf in another window PDF for

Topics: blood capillaries , glucose uptake , insulin , skeletal muscles , tumor necrosis factor-alpha

Diabetes November 2000, Vol.49, 1904-1909. doi:https://doi.org/10.2337/diabetes.49.11.1904

Lack of responses to a beta3-adrenergic agonist in lipoatrophic A-ZIP/F-1 mice.

O Gavrilova; B Marcus-Samuels; M L Reitman

Abstract

View articletitled, Lack of responses to a beta3-adrenergic agonist in lipoatrophic A-ZIP/F-1 mice.

Click here to open pdf in another window PDF for

Topics: agonists , mice

Diabetes November 2000, Vol.49, 1910-1916. doi:https://doi.org/10.2337/diabetes.49.11.1910

Adrenalectomy reverses obese phenotype and restores hypothalamic melanocortin tone in leptin-deficient ob/ob mice.

H Makimura; T M Mizuno; J Roberts; J Silverstein; J Beasley; C V Mobbs

Abstract

View articletitled, Adrenalectomy reverses obese phenotype and restores hypothalamic melanocortin tone in leptin-deficient ob/ob mice.

Click here to open pdf in another window PDF for

Topics: adrenalectomy , hypothalamus , leptin , mice , obesity

Diabetes November 2000, Vol.49, 1917-1923. doi:https://doi.org/10.2337/diabetes.49.11.1917

Dehydroepiandrosterone prevents oxidative injury induced by transient ischemia/reperfusion in the brain of diabetic rats.

M Aragno; S Parola; E Brignardello; A Mauro; E Tamagno; R Manti; O Danni; G Boccuzzi

Abstract

View articletitled, Dehydroepiandrosterone prevents oxidative injury induced by transient ischemia/reperfusion in the brain of diabetic rats.

Click here to open pdf in another window PDF for

Topics: brain , dehydroepiandrosterone , physiologic reperfusion , rats , reperfusion therapy

Diabetes November 2000, Vol.49, 1924-1931. doi:https://doi.org/10.2337/diabetes.49.11.1924

Diabetic peripheral neuropathy: evidence for apoptosis and associated mitochondrial dysfunction.

S Srinivasan; M Stevens; J W Wiley

Abstract

View articletitled, Diabetic peripheral neuropathy: evidence for apoptosis and associated mitochondrial dysfunction.

Click here to open pdf in another window PDF for

Topics: apoptosis , diabetic neuropathies , mitochondria

Diabetes November 2000, Vol.49, 1932-1938. doi:https://doi.org/10.2337/diabetes.49.11.1932

High glucose level and free fatty acid stimulate reactive oxygen species production through protein kinase C--dependent activation of NAD(P)H oxidase in cultured vascular cells.

T Inoguchi; P Li; F Umeda; H Y Yu; M Kakimoto; M Imamura; T Aoki; T Etoh; T Hashimoto; M Naruse; H Sano; H Utsumi; H Nawata

Abstract

View articletitled, High glucose level and free fatty acid stimulate reactive oxygen species production through protein kinase C--dependent activation of NAD(P)H oxidase in cultured vascular cells.

Click here to open pdf in another window PDF for

Topics: glucose , nonesterified fatty acids , oxidase , protein kinase , reactive oxygen species

Diabetes November 2000, Vol.49, 1939-1945. doi:https://doi.org/10.2337/diabetes.49.11.1939

Genetic obesity unmasks nonlinear interactions between murine type 2 diabetes susceptibility loci.

J P Stoehr; S T Nadler; K L Schueler; M E Rabaglia; B S Yandell; S A Metz; A D Attie

Abstract

View articletitled, Genetic obesity unmasks nonlinear interactions between murine type 2 diabetes susceptibility loci.

Click here to open pdf in another window PDF for

Topics: diabetes mellitus, type 2 , genetics , mice , obesity

Diabetes November 2000, Vol.49, 1946-1954. doi:https://doi.org/10.2337/diabetes.49.11.1946

beta-cell transcription factors and diabetes: no evidence for diabetes-associated mutations in the gene encoding the basic helix-loop-helix transcription factor neurogenic differentiation 4 (NEUROD4) in Japanese patients with MODY.

Y Horikawa; N J Cox; N Iwasaki; M Ogata; Y Iwamoto; V Schwitzgebel; M S German; G I Bell

Abstract

View articletitled, beta-cell transcription factors and diabetes: no evidence for diabetes-associated mutations in the gene encoding the basic helix-loop-helix transcription factor neurogenic differentiation 4 (NEUROD4) in Japanese patients with MODY.

Click here to open pdf in another window PDF for

Topics: genes , helix-loop-helix motifs , maturity onset diabetes mellitus in young , mutation , pancreatic beta cell

Diabetes November 2000, Vol.49, 1955-1957. doi:https://doi.org/10.2337/diabetes.49.11.1955

Lamin A/C gene: sex-determined expression of mutations in Dunnigan-type familial partial lipodystrophy and absence of coding mutations in congenital and acquired generalized lipoatrophy.

C Vigouroux; J Magré; M C Vantyghem; C Bourut; O Lascols; S Shackleton; D J Lloyd; B Guerci; G Padova; P Valensi; A Grimaldi; R Piquemal; P Touraine; R C Trembath; J Capeau

Abstract

View articletitled, Lamin A/C gene: sex-determined expression of mutations in Dunnigan-type familial partial lipodystrophy and absence of coding mutations in congenital and acquired generalized lipoatrophy.

Click here to open pdf in another window PDF for

Topics: familial partial lipodystrophy , genes , lamin type a , lipodystrophy , mutation

Diabetes November 2000, Vol.49, 1958-1962. doi:https://doi.org/10.2337/diabetes.49.11.1958

Triggering and amplifying pathways of regulation of insulin secretion by glucose.

Acyl-CoA inhibition of hexokinase in rat and human skeletal muscle is a potential mechanism of lipid-induced insulin resistance.

Beacon: a novel gene involved in the regulation of energy balance.

Sustained activation of insulin receptors internalized in GLUT4 vesicles of insulin-stimulated skeletal muscle.

Stimulation of MAPK cascades by insulin and osmotic shock: lack of an involvement of p38 mitogen-activated protein kinase in glucose transport in 3T3-L1 adipocytes.

Activation of p38 mitogen-activated protein kinase alpha and beta by insulin and contraction in rat skeletal muscle: potential role in the stimulation of glucose transport.

Virus-induced autoimmune diabetes: most beta-cells die through inflammatory cytokines and not perforin from autoreactive (anti-viral) cytotoxic T-lymphocytes.

Testicular sertoli cells protect islet beta-cells from autoimmune destruction in NOD mice by a transforming growth factor-beta1-dependent mechanism.

Cytokine- or chemically derived nitric oxide alters the expression of proteins detected by two-dimensional gel electrophoresis in neonatal rat islets of Langerhans.

PIP2 and ATP cooperatively prevent cytosolic Ca2+-induced modification of ATP-sensitive K+ channels in rat pancreatic beta-cells.

Glucose-induced [Ca2+]i abnormalities in human pancreatic islets: important role of overstimulation.

Poly(ADP-ribose) polymerase facilitates the repair of N-methylpurines in mitochondrial DNA.

Impaired insulin secretion and increased insulin sensitivity in familial maturity-onset diabetes of the young 4 (insulin promoter factor 1 gene).

Repeated 2-deoxy-D-glucose-induced glucoprivation attenuates Fos expression and glucoregulatory responses during subsequent glucoprivation.

The subcutaneous lipolytic response to regional neural stimulation is reduced in obese women.

Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia.

Unlike leptin, ciliary neurotrophic factor does not reverse the starvation-induced changes of serum corticosterone and hypothalamic neuropeptide levels but induces expression of hypothalamic inhibitors of leptin signaling.

Effects of differing durations of antecedent hypoglycemia on counterregulatory responses to subsequent hypoglycemia in normal humans.

Acute impairment of insulin-mediated capillary recruitment and glucose uptake in rat skeletal muscle in vivo by TNF-alpha.

Lack of responses to a beta3-adrenergic agonist in lipoatrophic A-ZIP/F-1 mice.

Adrenalectomy reverses obese phenotype and restores hypothalamic melanocortin tone in leptin-deficient ob/ob mice.

Dehydroepiandrosterone prevents oxidative injury induced by transient ischemia/reperfusion in the brain of diabetic rats.

Diabetic peripheral neuropathy: evidence for apoptosis and associated mitochondrial dysfunction.

High glucose level and free fatty acid stimulate reactive oxygen species production through protein kinase C--dependent activation of NAD(P)H oxidase in cultured vascular cells.

Genetic obesity unmasks nonlinear interactions between murine type 2 diabetes susceptibility loci.

beta-cell transcription factors and diabetes: no evidence for diabetes-associated mutations in the gene encoding the basic helix-loop-helix transcription factor neurogenic differentiation 4 (NEUROD4) in Japanese patients with MODY.

Lamin A/C gene: sex-determined expression of mutations in Dunnigan-type familial partial lipodystrophy and absence of coding mutations in congenital and acquired generalized lipoatrophy.

Email alerts

RSS Feeds

Journals

Books

Clinical Compendia

News

Other

About

Resources

Issues

Email alerts

RSS Feeds

Journals

Books

Clinical Compendia

News

Other

About

Resources

This Feature Is Available To Subscribers Only