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Volume 49, Issue 12

1 December 2000

ISSN 0012-1797

EISSN 1939-327X

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Organizing glucose disposal: emerging roles of the glycogen targeting subunits of protein phosphatase-1.

C B Newgard; M J Brady; R M O'Doherty; A R Saltiel

Abstract

View articletitled, Organizing glucose disposal: emerging roles of the glycogen targeting subunits of protein phosphatase-1.

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Topics: glucose , glycogen , protein phosphatase

Diabetes December 2000, Vol.49, 1967-1977. doi:https://doi.org/10.2337/diabetes.49.12.1967

Activation of glucose transport by AMP-activated protein kinase via stimulation of nitric oxide synthase.

L G Fryer; E Hajduch; F Rencurel; I P Salt; H S Hundal; D G Hardie; D Carling

Abstract

View articletitled, Activation of glucose transport by AMP-activated protein kinase via stimulation of nitric oxide synthase.

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Topics: glucose transport , nitric oxide synthase , protein kinase

Diabetes December 2000, Vol.49, 1978-1985. doi:https://doi.org/10.2337/diabetes.49.12.1978

Baculovirus-mediated gene transfer into pancreatic islet cells.

L Ma; N Tamarina; Y Wang; A Kuznetsov; N Patel; C Kending; B J Hering; L H Philipson

Abstract

View articletitled, Baculovirus-mediated gene transfer into pancreatic islet cells.

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Topics: baculoviruses , endocrine pancreas , gene transfer techniques

Diabetes December 2000, Vol.49, 1986-1991. doi:https://doi.org/10.2337/diabetes.49.12.1986

Early graft failure of xenogeneic islets in NOD mice is accompanied by high levels of interleukin-1 and low levels of transforming growth factor-beta mRNA in the grafts.

C A Gysemans; M Waer; D Valckx; J M Laureys; D Mihkalsky; R Bouillon; C Mathieu

Abstract

View articletitled, Early graft failure of xenogeneic islets in NOD mice is accompanied by high levels of interleukin-1 and low levels of transforming growth factor-beta mRNA in the grafts.

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Topics: interleukin-1 , mice, inbred nod , rna, messenger , tissue transplants , transforming growth factor beta

Diabetes December 2000, Vol.49, 1992-1997. doi:https://doi.org/10.2337/diabetes.49.12.1992

Suppression and acceleration of autoimmune diabetes by neutralization of endogenous interleukin-12 in NOD mice.

K Fujihira; M Nagata; H Moriyama; H Yasuda; K Arisawa; M Nakayama; S Maeda; M Kasuga; K Okumura; H Yagita; K Yokono

Abstract

View articletitled, Suppression and acceleration of autoimmune diabetes by neutralization of endogenous interleukin-12 in NOD mice.

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Topics: autoimmunity , interleukin-12 , mice, inbred nod , neutralization , psychological suppression

Diabetes December 2000, Vol.49, 1998-2006. doi:https://doi.org/10.2337/diabetes.49.12.1998

Interferon-gamma receptor signaling is dispensable in the development of autoimmune type 1 diabetes in NOD mice.

D V Serreze; C M Post; H D Chapman; E A Johnson; B Lu; P B Rothman

Abstract

View articletitled, Interferon-gamma receptor signaling is dispensable in the development of autoimmune type 1 diabetes in NOD mice.

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Topics: autoimmunity , diabetes mellitus, type 1 , interferon type ii , mice, inbred nod , signal transduction

Diabetes December 2000, Vol.49, 2007-2011. doi:https://doi.org/10.2337/diabetes.49.12.2007

Dehydroepiandrosterone sulfate and beta-cell function: enhanced glucose-induced insulin secretion and altered gene expression in rodent pancreatic beta-cells.

J S Dillon; G C Yaney; Y Zhou; N Voilley; S Bowen; S Chipkin; C R Bliss; V Schultz; F C Schuit; M Prentki; D J Waxman; B E Corkey

Abstract

View articletitled, Dehydroepiandrosterone sulfate and beta-cell function: enhanced glucose-induced insulin secretion and altered gene expression in rodent pancreatic beta-cells.

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Topics: dehydroepiandrosterone sulfate , gene expression , glucose , insulin secretion , pancreas

Diabetes December 2000, Vol.49, 2012-2020. doi:https://doi.org/10.2337/diabetes.49.12.2012

Recombinant human betacellulin promotes the neogenesis of beta-cells and ameliorates glucose intolerance in mice with diabetes induced by selective alloxan perfusion.

K Yamamoto; J Miyagawa; M Waguri; R Sasada; K Igarashi; M Li; T Nammo; M Moriwaki; A Imagawa; K Yamagata; H Nakajima; M Namba; Y Tochino; T Hanafusa; Y Matsuzawa

Abstract

View articletitled, Recombinant human betacellulin promotes the neogenesis of beta-cells and ameliorates glucose intolerance in mice with diabetes induced by selective alloxan perfusion.

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Topics: alloxan , betacellulin , glucose intolerance , mice , perfusion

Diabetes December 2000, Vol.49, 2021-2027. doi:https://doi.org/10.2337/diabetes.49.12.2021

Differential patterns of glucose-induced electrical activity and intracellular calcium responses in single mouse and rat pancreatic islets.

C M Antunes; A P Salgado; L M Rosário; R M Santos

Abstract

View articletitled, Differential patterns of glucose-induced electrical activity and intracellular calcium responses in single mouse and rat pancreatic islets.

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Topics: calcium , electrical activity of brain , endocrine pancreas , glucose , mice

Diabetes December 2000, Vol.49, 2028-2038. doi:https://doi.org/10.2337/diabetes.49.12.2028

Hedgehog signaling regulation of insulin production by pancreatic beta-cells.

M K Thomas; N Rastalsky; J H Lee; J F Habener

Abstract

View articletitled, Hedgehog signaling regulation of insulin production by pancreatic beta-cells.

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Topics: erinaceidae , insulin , pancreas , signal transduction

Diabetes December 2000, Vol.49, 2039-2047. doi:https://doi.org/10.2337/diabetes.49.12.2039

Subcellular localization, mobility, and kinetic activity of glucokinase in glucose-responsive insulin-secreting cells.

M Stubbs; S Aiston; L Agius

Abstract

View articletitled, Subcellular localization, mobility, and kinetic activity of glucokinase in glucose-responsive insulin-secreting cells.

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Topics: glucokinase , glucose , kinetics , mobility , pancreatic beta cell

Diabetes December 2000, Vol.49, 2048-2055. doi:https://doi.org/10.2337/diabetes.49.12.2048

beta-cell glucokinase deficiency and hyperglycemia are associated with reduced islet amyloid deposition in a mouse model of type 2 diabetes.

S Andrikopoulos; C B Verchere; Y Terauchi; T Kadowaki; S E Kahn

Abstract

View articletitled, beta-cell glucokinase deficiency and hyperglycemia are associated with reduced islet amyloid deposition in a mouse model of type 2 diabetes.

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Topics: amyloid , diabetes mellitus, type 2 , glucokinase , hyperglycemia , mice

Diabetes December 2000, Vol.49, 2056-2062. doi:https://doi.org/10.2337/diabetes.49.12.2056

Mechanism by which metformin reduces glucose production in type 2 diabetes.

R S Hundal; M Krssak; S Dufour; D Laurent; V Lebon; V Chandramouli; S E Inzucchi; W C Schumann; K F Petersen; B R Landau; G I Shulman

Abstract

View articletitled, Mechanism by which metformin reduces glucose production in type 2 diabetes.

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Topics: diabetes mellitus, type 2 , glucose , metformin

Diabetes December 2000, Vol.49, 2063-2069. doi:https://doi.org/10.2337/diabetes.49.12.2063

Overexpression of glutamine: fructose-6-phosphate amidotransferase in the liver of transgenic mice results in enhanced glycogen storage, hyperlipidemia, obesity, and impaired glucose tolerance.

G Veerababu; J Tang; R T Hoffman; M C Daniels; L F Hebert, Jr; E D Crook; R C Cooksey; D A McClain

Abstract

View articletitled, Overexpression of glutamine: fructose-6-phosphate amidotransferase in the liver of transgenic mice results in enhanced glycogen storage, hyperlipidemia, obesity, and impaired glucose tolerance.

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Topics: fructose , glucose intolerance , glutamine , glycogen , hyperlipidemia

Diabetes December 2000, Vol.49, 2070-2078. doi:https://doi.org/10.2337/diabetes.49.12.2070

Effects of skyrin, a receptor-selective glucagon antagonist, in rat and human hepatocytes.

J C Parker; R K McPherson; K M Andrews; C B Levy; J S Dubins; J E Chin; P V Perry; B Hulin; D A Perry; T Inagaki; K A Dekker; K Tachikawa; Y Sugie; J L Treadway

Abstract

View articletitled, Effects of skyrin, a receptor-selective glucagon antagonist, in rat and human hepatocytes.

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Topics: antagonists , glucagon , hepatocytes

Diabetes December 2000, Vol.49, 2079-2086. doi:https://doi.org/10.2337/diabetes.49.12.2079

Paradoxical effect of troglitazone in normal animals: enhancement of adipocyte but reduction of liver insulin sensitivity.

M K Dea; G W Van Citters; M Ader; S D Mittelman; A L Sunehag; R N Bergman

Abstract

View articletitled, Paradoxical effect of troglitazone in normal animals: enhancement of adipocyte but reduction of liver insulin sensitivity.

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Topics: adipocytes , insulin sensitivity , liver , troglitazone

Diabetes December 2000, Vol.49, 2087-2093. doi:https://doi.org/10.2337/diabetes.49.12.2087

A high fasting plasma insulin concentration predicts type 2 diabetes independent of insulin resistance: evidence for a pathogenic role of relative hyperinsulinemia.

C Weyer; R L Hanson; P A Tataranni; C Bogardus; R E Pratley

Abstract

View articletitled, A high fasting plasma insulin concentration predicts type 2 diabetes independent of insulin resistance: evidence for a pathogenic role of relative hyperinsulinemia.

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Topics: diabetes mellitus, type 2 , fasting , hyperinsulinism , insulin , insulin resistance

Diabetes December 2000, Vol.49, 2094-2101. doi:https://doi.org/10.2337/diabetes.49.12.2094

Impaired oxidation of plasma-derived fatty acids in type 2 diabetic subjects during moderate-intensity exercise.

E E Blaak; D P van Aggel-Leijssen; A J Wagenmakers; W H Saris; M A van Baak

Abstract

View articletitled, Impaired oxidation of plasma-derived fatty acids in type 2 diabetic subjects during moderate-intensity exercise.

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Topics: fatty acids , oxidation , plasma

Diabetes December 2000, Vol.49, 2102-2107. doi:https://doi.org/10.2337/diabetes.49.12.2102

Thiazolidinediones inhibit the expression of beta3-adrenergic receptors at a transcriptional level.

E Bakopanos; J E Silva

Abstract

View articletitled, Thiazolidinediones inhibit the expression of beta3-adrenergic receptors at a transcriptional level.

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Topics: receptors, adrenergic, beta-3 , thiazolidinedione , transcription, genetic

Diabetes December 2000, Vol.49, 2108-2115. doi:https://doi.org/10.2337/diabetes.49.12.2108

Longitudinal compensation for fat-induced insulin resistance includes reduced insulin clearance and enhanced beta-cell response.

S D Mittelman; G W Van Citters; S P Kim; D A Davis; M K Dea; M Hamilton-Wessler; R N Bergman

Abstract

View articletitled, Longitudinal compensation for fat-induced insulin resistance includes reduced insulin clearance and enhanced beta-cell response.

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Topics: drug clearance , insulin , insulin resistance , pancreatic beta cell

Diabetes December 2000, Vol.49, 2116-2125. doi:https://doi.org/10.2337/diabetes.49.12.2116

A model to explore the interaction between muscle insulin resistance and beta-cell dysfunction in the development of type 2 diabetes.

F Mauvais-Jarvis; A Virkamaki; M D Michael; J N Winnay; A Zisman; R N Kulkarni; C R Kahn

Abstract

View articletitled, A model to explore the interaction between muscle insulin resistance and beta-cell dysfunction in the development of type 2 diabetes.

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Topics: diabetes mellitus, type 2 , insulin resistance , pancreatic beta cell

Diabetes December 2000, Vol.49, 2126-2134. doi:https://doi.org/10.2337/diabetes.49.12.2126

Prandial glucose effectiveness and fasting gluconeogenesis in insulin-resistant first-degree relatives of patients with type 2 diabetes.

M F Nielsen; B Nyholm; A Caumo; V Chandramouli; W C Schumann; C Cobelli; B R Landau; R A Rizza; O Schmitz

Abstract

View articletitled, Prandial glucose effectiveness and fasting gluconeogenesis in insulin-resistant first-degree relatives of patients with type 2 diabetes.

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Topics: diabetes mellitus, type 2 , fasting , gluconeogenesis , glucose , insulin

Diabetes December 2000, Vol.49, 2135-2141. doi:https://doi.org/10.2337/diabetes.49.12.2135

Pharmacokinetics and pharmacodynamics of subcutaneous injection of long-acting human insulin analog glargine, NPH insulin, and ultralente human insulin and continuous subcutaneous infusion of insulin lispro.

M Lepore; S Pampanelli; C Fanelli; F Porcellati; L Bartocci; A Di Vincenzo; C Cordoni; E Costa; P Brunetti; G B Bolli

Abstract

View articletitled, Pharmacokinetics and pharmacodynamics of subcutaneous injection of long-acting human insulin analog glargine, NPH insulin, and ultralente human insulin and continuous subcutaneous infusion of insulin lispro.

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Topics: insulin , insulin administration , insulin analogs , insulin glargine , insulin lispro

Diabetes December 2000, Vol.49, 2142-2148. doi:https://doi.org/10.2337/diabetes.49.12.2142

Impaired in vivo stimulation of lipolysis in adipose tissue by selective beta2-adrenergic agonist in obese adolescent girls.

S Enoksson; M Talbot; F Rife; W V Tamborlane; R S Sherwin; S Caprio

Abstract

View articletitled, Impaired in vivo stimulation of lipolysis in adipose tissue by selective beta2-adrenergic agonist in obese adolescent girls.

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Topics: adipose tissue , adolescent , agonists , girls , lipolysis

Diabetes December 2000, Vol.49, 2149-2153. doi:https://doi.org/10.2337/diabetes.49.12.2149

Exercise and thiazolidinedione therapy normalize insulin action in the obese Zucker fatty rat.

A L Hevener; D Reichart; J Olefsky

Abstract

View articletitled, Exercise and thiazolidinedione therapy normalize insulin action in the obese Zucker fatty rat.

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Topics: insulin , obesity , thiazolidinedione

Diabetes December 2000, Vol.49, 2154-2159. doi:https://doi.org/10.2337/diabetes.49.12.2154

Native and modified LDL activate extracellular signal-regulated kinases in mesangial cells.

A J Jenkins; V Velarde; R L Klein; K C Joyce; K D Phillips; R K Mayfield; T J Lyons; A A Jaffa

Abstract

View articletitled, Native and modified LDL activate extracellular signal-regulated kinases in mesangial cells.

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Topics: loudness discomfort level , low-density lipoproteins , mesangial cells , mitogen-activated protein kinases

Diabetes December 2000, Vol.49, 2160-2169. doi:https://doi.org/10.2337/diabetes.49.12.2160

Defective intracellular antioxidant enzyme production in type 1 diabetic patients with nephropathy.

A Ceriello; A Morocutti; F Mercuri; L Quagliaro; M Moro; G Damante; G C Viberti

Abstract

View articletitled, Defective intracellular antioxidant enzyme production in type 1 diabetic patients with nephropathy.

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Topics: antioxidants , enzymes , kidney diseases

Diabetes December 2000, Vol.49, 2170-2177. doi:https://doi.org/10.2337/diabetes.49.12.2170

Diabetes in the Goto-Kakizaki rat is accompanied by impaired insulin-mediated myosin-bound phosphatase activation and vascular smooth muscle cell relaxation.

O A Sandu; L Ragolia; N Begum

Abstract

View articletitled, Diabetes in the Goto-Kakizaki rat is accompanied by impaired insulin-mediated myosin-bound phosphatase activation and vascular smooth muscle cell relaxation.

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Topics: insulin , muscle, smooth, vascular , myosins , phosphoric monoester hydrolases

Diabetes December 2000, Vol.49, 2178-2189. doi:https://doi.org/10.2337/diabetes.49.12.2178

APOE polymorphisms and the development of diabetic nephropathy in type 1 diabetes: results of case-control and family-based studies.

S Araki; D K Moczulski; L Hanna; L J Scott; J H Warram; A S Krolewski

Abstract

View articletitled, APOE polymorphisms and the development of diabetic nephropathy in type 1 diabetes: results of case-control and family-based studies.

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Topics: apolipoprotein e , diabetes mellitus, type 1 , diabetic nephropathy , polymorphism

Diabetes December 2000, Vol.49, 2190-2195. doi:https://doi.org/10.2337/diabetes.49.12.2190

A common promoter variant of the leptin gene is associated with changes in the relationship between serum leptin and fat mass in obese girls.

C Le Stunff; C Le Bihan; N J Schork; P Bougnères

Abstract

View articletitled, A common promoter variant of the leptin gene is associated with changes in the relationship between serum leptin and fat mass in obese girls.

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Topics: genes , girls , leptin , obesity , serum leptin measurement

Diabetes December 2000, Vol.49, 2196-2200. doi:https://doi.org/10.2337/diabetes.49.12.2196

Parental transmission of type 2 diabetes: the Framingham Offspring Study.

J B Meigs; L A Cupples; P W Wilson

Abstract

View articletitled, Parental transmission of type 2 diabetes: the Framingham Offspring Study.

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Topics: diabetes mellitus, type 2 , framingham offspring study

Diabetes December 2000, Vol.49, 2201-2207. doi:https://doi.org/10.2337/diabetes.49.12.2201

Intrauterine exposure to diabetes conveys risks for type 2 diabetes and obesity: a study of discordant sibships.

D Dabelea; R L Hanson; R S Lindsay; D J Pettitt; G Imperatore; M M Gabir; J Roumain; P H Bennett; W C Knowler

Abstract

View articletitled, Intrauterine exposure to diabetes conveys risks for type 2 diabetes and obesity: a study of discordant sibships.

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Topics: diabetes mellitus, type 2 , intrauterine route of drug administration , obesity

Diabetes December 2000, Vol.49, 2208-2211. doi:https://doi.org/10.2337/diabetes.49.12.2208

Further evidence for a susceptibility locus for type 2 diabetes on chromosome 20q13.1-q13.2.

T Klupa; M T Malecki; M Pezzolesi; L Ji; S Curtis; C D Langefeld; S S Rich; J H Warram; A S Krolewski

Abstract

View articletitled, Further evidence for a susceptibility locus for type 2 diabetes on chromosome 20q13.1-q13.2.

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Topics: chromosomes , diabetes mellitus, type 2

Diabetes December 2000, Vol.49, 2212-2216. doi:https://doi.org/10.2337/diabetes.49.12.2212

Non-class II HLA gene associated with type 1 diabetes maps to the 240-kb region near HLA-B.

S Nejentsev; Z Gombos; A P Laine; R Veijola; M Knip; O Simell; O Vaarala; H K Akerblom; J Ilonen

Abstract

View articletitled, Non-class II HLA gene associated with type 1 diabetes maps to the 240-kb region near HLA-B.

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Topics: diabetes mellitus, type 1 , hla-b antigens , human leukocyte antigen gene , maps

Diabetes December 2000, Vol.49, 2217-2221. doi:https://doi.org/10.2337/diabetes.49.12.2217

Cd36 and molecular mechanisms of insulin resistance in the stroke-prone spontaneously hypertensive rat.

M Collison; A M Glazier; D Graham; J J Morton; M H Dominiczak; T J Aitman; J M Connell; G W Gould; A F Dominiczak

Abstract

View articletitled, Cd36 and molecular mechanisms of insulin resistance in the stroke-prone spontaneously hypertensive rat.

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Topics: cd36 antigens , cerebrovascular accident , insulin resistance , ischemic stroke , rats, inbred shr

Diabetes December 2000, Vol.49, 2222-2226. doi:https://doi.org/10.2337/diabetes.49.12.2222

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