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Volume 49, Issue 12
1 December 2000
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ISSN 0012-1797
EISSN 1939-327X
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Organizing glucose disposal: emerging roles of the glycogen targeting subunits of protein phosphatase-1.
C B Newgard; M J Brady; R M O'Doherty; A R Saltiel
View articletitled, Organizing glucose disposal: emerging roles of the glycogen targeting subunits of protein phosphatase-1.
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Diabetes December 2000, Vol.49, 1967-1977. doi:https://doi.org/10.2337/diabetes.49.12.1967
Activation of glucose transport by AMP-activated protein kinase via stimulation of nitric oxide synthase.
L G Fryer; E Hajduch; F Rencurel; I P Salt; H S Hundal; D G Hardie; D Carling
View articletitled, Activation of glucose transport by AMP-activated protein kinase via stimulation of nitric oxide synthase.
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Diabetes December 2000, Vol.49, 1978-1985. doi:https://doi.org/10.2337/diabetes.49.12.1978
Baculovirus-mediated gene transfer into pancreatic islet cells.
L Ma; N Tamarina; Y Wang; A Kuznetsov; N Patel; C Kending; B J Hering; L H Philipson
View articletitled, Baculovirus-mediated gene transfer into pancreatic islet cells.
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Diabetes December 2000, Vol.49, 1986-1991. doi:https://doi.org/10.2337/diabetes.49.12.1986
Early graft failure of xenogeneic islets in NOD mice is accompanied by high levels of interleukin-1 and low levels of transforming growth factor-beta mRNA in the grafts.
C A Gysemans; M Waer; D Valckx; J M Laureys; D Mihkalsky; R Bouillon; C Mathieu
View articletitled, Early graft failure of xenogeneic islets in NOD mice is accompanied by high levels of interleukin-1 and low levels of transforming growth factor-beta mRNA in the grafts.
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Diabetes December 2000, Vol.49, 1992-1997. doi:https://doi.org/10.2337/diabetes.49.12.1992
Suppression and acceleration of autoimmune diabetes by neutralization of endogenous interleukin-12 in NOD mice.
K Fujihira; M Nagata; H Moriyama; H Yasuda; K Arisawa; M Nakayama; S Maeda; M Kasuga; K Okumura; H Yagita; K Yokono
View articletitled, Suppression and acceleration of autoimmune diabetes by neutralization of endogenous interleukin-12 in NOD mice.
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Diabetes December 2000, Vol.49, 1998-2006. doi:https://doi.org/10.2337/diabetes.49.12.1998
Interferon-gamma receptor signaling is dispensable in the development of autoimmune type 1 diabetes in NOD mice.
D V Serreze; C M Post; H D Chapman; E A Johnson; B Lu; P B Rothman
View articletitled, Interferon-gamma receptor signaling is dispensable in the development of autoimmune type 1 diabetes in NOD mice.
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Diabetes December 2000, Vol.49, 2007-2011. doi:https://doi.org/10.2337/diabetes.49.12.2007
Dehydroepiandrosterone sulfate and beta-cell function: enhanced glucose-induced insulin secretion and altered gene expression in rodent pancreatic beta-cells.
J S Dillon; G C Yaney; Y Zhou; N Voilley; S Bowen; S Chipkin; C R Bliss; V Schultz; F C Schuit; M Prentki; D J Waxman; B E Corkey
View articletitled, Dehydroepiandrosterone sulfate and beta-cell function: enhanced glucose-induced insulin secretion and altered gene expression in rodent pancreatic beta-cells.
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Diabetes December 2000, Vol.49, 2012-2020. doi:https://doi.org/10.2337/diabetes.49.12.2012
Recombinant human betacellulin promotes the neogenesis of beta-cells and ameliorates glucose intolerance in mice with diabetes induced by selective alloxan perfusion.
K Yamamoto; J Miyagawa; M Waguri; R Sasada; K Igarashi; M Li; T Nammo; M Moriwaki; A Imagawa; K Yamagata; H Nakajima; M Namba; Y Tochino; T Hanafusa; Y Matsuzawa
View articletitled, Recombinant human betacellulin promotes the neogenesis of beta-cells and ameliorates glucose intolerance in mice with diabetes induced by selective alloxan perfusion.
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Diabetes December 2000, Vol.49, 2021-2027. doi:https://doi.org/10.2337/diabetes.49.12.2021
Differential patterns of glucose-induced electrical activity and intracellular calcium responses in single mouse and rat pancreatic islets.
C M Antunes; A P Salgado; L M Rosário; R M Santos
View articletitled, Differential patterns of glucose-induced electrical activity and intracellular calcium responses in single mouse and rat pancreatic islets.
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Diabetes December 2000, Vol.49, 2028-2038. doi:https://doi.org/10.2337/diabetes.49.12.2028
Hedgehog signaling regulation of insulin production by pancreatic beta-cells.
M K Thomas; N Rastalsky; J H Lee; J F Habener
View articletitled, Hedgehog signaling regulation of insulin production by pancreatic beta-cells.
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Diabetes December 2000, Vol.49, 2039-2047. doi:https://doi.org/10.2337/diabetes.49.12.2039
Subcellular localization, mobility, and kinetic activity of glucokinase in glucose-responsive insulin-secreting cells.
M Stubbs; S Aiston; L Agius
View articletitled, Subcellular localization, mobility, and kinetic activity of glucokinase in glucose-responsive insulin-secreting cells.
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Diabetes December 2000, Vol.49, 2048-2055. doi:https://doi.org/10.2337/diabetes.49.12.2048
beta-cell glucokinase deficiency and hyperglycemia are associated with reduced islet amyloid deposition in a mouse model of type 2 diabetes.
S Andrikopoulos; C B Verchere; Y Terauchi; T Kadowaki; S E Kahn
View articletitled, beta-cell glucokinase deficiency and hyperglycemia are associated with reduced islet amyloid deposition in a mouse model of type 2 diabetes.
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Diabetes December 2000, Vol.49, 2056-2062. doi:https://doi.org/10.2337/diabetes.49.12.2056
Mechanism by which metformin reduces glucose production in type 2 diabetes.
R S Hundal; M Krssak; S Dufour; D Laurent; V Lebon; V Chandramouli; S E Inzucchi; W C Schumann; K F Petersen; B R Landau; G I Shulman
View articletitled, Mechanism by which metformin reduces glucose production in type 2 diabetes.
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Diabetes December 2000, Vol.49, 2063-2069. doi:https://doi.org/10.2337/diabetes.49.12.2063
Overexpression of glutamine: fructose-6-phosphate amidotransferase in the liver of transgenic mice results in enhanced glycogen storage, hyperlipidemia, obesity, and impaired glucose tolerance.
G Veerababu; J Tang; R T Hoffman; M C Daniels; L F Hebert, Jr; E D Crook; R C Cooksey; D A McClain
View articletitled, Overexpression of glutamine: fructose-6-phosphate amidotransferase in the liver of transgenic mice results in enhanced glycogen storage, hyperlipidemia, obesity, and impaired glucose tolerance.
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Diabetes December 2000, Vol.49, 2070-2078. doi:https://doi.org/10.2337/diabetes.49.12.2070
Effects of skyrin, a receptor-selective glucagon antagonist, in rat and human hepatocytes.
J C Parker; R K McPherson; K M Andrews; C B Levy; J S Dubins; J E Chin; P V Perry; B Hulin; D A Perry; T Inagaki; K A Dekker; K Tachikawa; Y Sugie; J L Treadway
View articletitled, Effects of skyrin, a receptor-selective glucagon antagonist, in rat and human hepatocytes.
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Diabetes December 2000, Vol.49, 2079-2086. doi:https://doi.org/10.2337/diabetes.49.12.2079
Paradoxical effect of troglitazone in normal animals: enhancement of adipocyte but reduction of liver insulin sensitivity.
M K Dea; G W Van Citters; M Ader; S D Mittelman; A L Sunehag; R N Bergman
View articletitled, Paradoxical effect of troglitazone in normal animals: enhancement of adipocyte but reduction of liver insulin sensitivity.
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Diabetes December 2000, Vol.49, 2087-2093. doi:https://doi.org/10.2337/diabetes.49.12.2087
A high fasting plasma insulin concentration predicts type 2 diabetes independent of insulin resistance: evidence for a pathogenic role of relative hyperinsulinemia.
C Weyer; R L Hanson; P A Tataranni; C Bogardus; R E Pratley
View articletitled, A high fasting plasma insulin concentration predicts type 2 diabetes independent of insulin resistance: evidence for a pathogenic role of relative hyperinsulinemia.
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Diabetes December 2000, Vol.49, 2094-2101. doi:https://doi.org/10.2337/diabetes.49.12.2094
Impaired oxidation of plasma-derived fatty acids in type 2 diabetic subjects during moderate-intensity exercise.
E E Blaak; D P van Aggel-Leijssen; A J Wagenmakers; W H Saris; M A van Baak
View articletitled, Impaired oxidation of plasma-derived fatty acids in type 2 diabetic subjects during moderate-intensity exercise.
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Diabetes December 2000, Vol.49, 2102-2107. doi:https://doi.org/10.2337/diabetes.49.12.2102
Thiazolidinediones inhibit the expression of beta3-adrenergic receptors at a transcriptional level.
E Bakopanos; J E Silva
View articletitled, Thiazolidinediones inhibit the expression of beta3-adrenergic receptors at a transcriptional level.
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Diabetes December 2000, Vol.49, 2108-2115. doi:https://doi.org/10.2337/diabetes.49.12.2108
Longitudinal compensation for fat-induced insulin resistance includes reduced insulin clearance and enhanced beta-cell response.
S D Mittelman; G W Van Citters; S P Kim; D A Davis; M K Dea; M Hamilton-Wessler; R N Bergman
View articletitled, Longitudinal compensation for fat-induced insulin resistance includes reduced insulin clearance and enhanced beta-cell response.
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Diabetes December 2000, Vol.49, 2116-2125. doi:https://doi.org/10.2337/diabetes.49.12.2116
A model to explore the interaction between muscle insulin resistance and beta-cell dysfunction in the development of type 2 diabetes.
F Mauvais-Jarvis; A Virkamaki; M D Michael; J N Winnay; A Zisman; R N Kulkarni; C R Kahn
View articletitled, A model to explore the interaction between muscle insulin resistance and beta-cell dysfunction in the development of type 2 diabetes.
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Diabetes December 2000, Vol.49, 2126-2134. doi:https://doi.org/10.2337/diabetes.49.12.2126
Prandial glucose effectiveness and fasting gluconeogenesis in insulin-resistant first-degree relatives of patients with type 2 diabetes.
M F Nielsen; B Nyholm; A Caumo; V Chandramouli; W C Schumann; C Cobelli; B R Landau; R A Rizza; O Schmitz
View articletitled, Prandial glucose effectiveness and fasting gluconeogenesis in insulin-resistant first-degree relatives of patients with type 2 diabetes.
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Diabetes December 2000, Vol.49, 2135-2141. doi:https://doi.org/10.2337/diabetes.49.12.2135
Pharmacokinetics and pharmacodynamics of subcutaneous injection of long-acting human insulin analog glargine, NPH insulin, and ultralente human insulin and continuous subcutaneous infusion of insulin lispro.
M Lepore; S Pampanelli; C Fanelli; F Porcellati; L Bartocci; A Di Vincenzo; C Cordoni; E Costa; P Brunetti; G B Bolli
View articletitled, Pharmacokinetics and pharmacodynamics of subcutaneous injection of long-acting human insulin analog glargine, NPH insulin, and ultralente human insulin and continuous subcutaneous infusion of insulin lispro.
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Diabetes December 2000, Vol.49, 2142-2148. doi:https://doi.org/10.2337/diabetes.49.12.2142
Impaired in vivo stimulation of lipolysis in adipose tissue by selective beta2-adrenergic agonist in obese adolescent girls.
S Enoksson; M Talbot; F Rife; W V Tamborlane; R S Sherwin; S Caprio
View articletitled, Impaired in vivo stimulation of lipolysis in adipose tissue by selective beta2-adrenergic agonist in obese adolescent girls.
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Diabetes December 2000, Vol.49, 2149-2153. doi:https://doi.org/10.2337/diabetes.49.12.2149
Exercise and thiazolidinedione therapy normalize insulin action in the obese Zucker fatty rat.
A L Hevener; D Reichart; J Olefsky
View articletitled, Exercise and thiazolidinedione therapy normalize insulin action in the obese Zucker fatty rat.
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Diabetes December 2000, Vol.49, 2154-2159. doi:https://doi.org/10.2337/diabetes.49.12.2154
Native and modified LDL activate extracellular signal-regulated kinases in mesangial cells.
A J Jenkins; V Velarde; R L Klein; K C Joyce; K D Phillips; R K Mayfield; T J Lyons; A A Jaffa
View articletitled, Native and modified LDL activate extracellular signal-regulated kinases in mesangial cells.
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Diabetes December 2000, Vol.49, 2160-2169. doi:https://doi.org/10.2337/diabetes.49.12.2160
Defective intracellular antioxidant enzyme production in type 1 diabetic patients with nephropathy.
A Ceriello; A Morocutti; F Mercuri; L Quagliaro; M Moro; G Damante; G C Viberti
View articletitled, Defective intracellular antioxidant enzyme production in type 1 diabetic patients with nephropathy.
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Diabetes December 2000, Vol.49, 2170-2177. doi:https://doi.org/10.2337/diabetes.49.12.2170
Diabetes in the Goto-Kakizaki rat is accompanied by impaired insulin-mediated myosin-bound phosphatase activation and vascular smooth muscle cell relaxation.
O A Sandu; L Ragolia; N Begum
View articletitled, Diabetes in the Goto-Kakizaki rat is accompanied by impaired insulin-mediated myosin-bound phosphatase activation and vascular smooth muscle cell relaxation.
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Diabetes December 2000, Vol.49, 2178-2189. doi:https://doi.org/10.2337/diabetes.49.12.2178
APOE polymorphisms and the development of diabetic nephropathy in type 1 diabetes: results of case-control and family-based studies.
S Araki; D K Moczulski; L Hanna; L J Scott; J H Warram; A S Krolewski
View articletitled, APOE polymorphisms and the development of diabetic nephropathy in type 1 diabetes: results of case-control and family-based studies.
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Diabetes December 2000, Vol.49, 2190-2195. doi:https://doi.org/10.2337/diabetes.49.12.2190
A common promoter variant of the leptin gene is associated with changes in the relationship between serum leptin and fat mass in obese girls.
C Le Stunff; C Le Bihan; N J Schork; P Bougnères
View articletitled, A common promoter variant of the leptin gene is associated with changes in the relationship between serum leptin and fat mass in obese girls.
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Diabetes December 2000, Vol.49, 2196-2200. doi:https://doi.org/10.2337/diabetes.49.12.2196
Parental transmission of type 2 diabetes: the Framingham Offspring Study.
J B Meigs; L A Cupples; P W Wilson
View articletitled, Parental transmission of type 2 diabetes: the Framingham Offspring Study.
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Diabetes December 2000, Vol.49, 2201-2207. doi:https://doi.org/10.2337/diabetes.49.12.2201
Intrauterine exposure to diabetes conveys risks for type 2 diabetes and obesity: a study of discordant sibships.
D Dabelea; R L Hanson; R S Lindsay; D J Pettitt; G Imperatore; M M Gabir; J Roumain; P H Bennett; W C Knowler
View articletitled, Intrauterine exposure to diabetes conveys risks for type 2 diabetes and obesity: a study of discordant sibships.
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Diabetes December 2000, Vol.49, 2208-2211. doi:https://doi.org/10.2337/diabetes.49.12.2208
Further evidence for a susceptibility locus for type 2 diabetes on chromosome 20q13.1-q13.2.
T Klupa; M T Malecki; M Pezzolesi; L Ji; S Curtis; C D Langefeld; S S Rich; J H Warram; A S Krolewski
View articletitled, Further evidence for a susceptibility locus for type 2 diabetes on chromosome 20q13.1-q13.2.
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Diabetes December 2000, Vol.49, 2212-2216. doi:https://doi.org/10.2337/diabetes.49.12.2212
Non-class II HLA gene associated with type 1 diabetes maps to the 240-kb region near HLA-B.
S Nejentsev; Z Gombos; A P Laine; R Veijola; M Knip; O Simell; O Vaarala; H K Akerblom; J Ilonen
View articletitled, Non-class II HLA gene associated with type 1 diabetes maps to the 240-kb region near HLA-B.
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Diabetes December 2000, Vol.49, 2217-2221. doi:https://doi.org/10.2337/diabetes.49.12.2217
Cd36 and molecular mechanisms of insulin resistance in the stroke-prone spontaneously hypertensive rat.
M Collison; A M Glazier; D Graham; J J Morton; M H Dominiczak; T J Aitman; J M Connell; G W Gould; A F Dominiczak
View articletitled, Cd36 and molecular mechanisms of insulin resistance in the stroke-prone spontaneously hypertensive rat.
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Diabetes December 2000, Vol.49, 2222-2226. doi:https://doi.org/10.2337/diabetes.49.12.2222
Management of Latent Autoimmune Diabetes in Adults: A Consensus Statement From an International Expert Panel
MRI Metrics of Cerebral Endothelial Cell–Derived Exosomes for the Treatment of Cognitive Dysfunction Induced in Aging Rats Subjected to Type 2 Diabetes
713-P: Is There a Correct Time to Measure Fasting Blood Sugar in Persons with Type 2 Diabetes Melitus?
227-OR: Tirzepatide Reduces HbA1c and Body Weight Significantly More than Placebo Regardless of Insulin Sensitivity and Beta-Cell Function—Post Hoc Analysis from SURMOUNT-2
Elevated First-Trimester Neutrophil Count Is Closely Associated With the Development of Maternal Gestational Diabetes Mellitus and Adverse Pregnancy Outcomes
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