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Volume 49, Issue 3

1 March 2000

ISSN 0012-1797

EISSN 1939-327X

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Diverse roles of K(ATP) channels learned from Kir6.2 genetically engineered mice.

S Seino; T Iwanaga; K Nagashima; T Miki

Abstract

View articletitled, Diverse roles of K(ATP) channels learned from Kir6.2 genetically engineered mice.

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Topics: genetic engineering , mice

Diabetes March 2000, Vol.49, 311-318. doi:https://doi.org/10.2337/diabetes.49.3.311

Induction of fatty acid translocase/CD36, peroxisome proliferator-activated receptor-gamma2, leptin, uncoupling proteins 2 and 3, and tumor necrosis factor-alpha gene expression in human subcutaneous fat by lipid infusion.

E Nisoli; M O Carruba; C Tonello; C Macor; G Federspil; R Vettor

Abstract

View articletitled, Induction of fatty acid translocase/CD36, peroxisome proliferator-activated receptor-gamma2, leptin, uncoupling proteins 2 and 3, and tumor necrosis factor-alpha gene expression in human subcutaneous fat by lipid infusion.

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Topics: cd36 antigens , fat, subcutaneous , fatty acids , gene expression , infusion procedures

Diabetes March 2000, Vol.49, 319-324. doi:https://doi.org/10.2337/diabetes.49.3.319

Insulin signaling and insulin sensitivity after exercise in human skeletal muscle.

J F Wojtaszewski; B F Hansen; Gade; B Kiens; J F Markuns; L J Goodyear; E A Richter

Abstract

View articletitled, Insulin signaling and insulin sensitivity after exercise in human skeletal muscle.

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Topics: insulin , insulin sensitivity , signal transduction , skeletal muscles

Diabetes March 2000, Vol.49, 325-331. doi:https://doi.org/10.2337/diabetes.49.3.325

Constitutively active mitogen-activated protein kinase kinase increases GLUT1 expression and recruits both GLUT1 and GLUT4 at the cell surface in 3T3-L1 adipocytes.

Y Yamamoto; Y Yoshimasa; M Koh; J Suga; H Masuzaki; Y Ogawa; K Hosoda; H Nishimura; Y Watanabe; G Inoue; K Nakao

Abstract

View articletitled, Constitutively active mitogen-activated protein kinase kinase increases GLUT1 expression and recruits both GLUT1 and GLUT4 at the cell surface in 3T3-L1 adipocytes.

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Topics: adipocytes , mitogen-activated protein kinases , phosphotransferases

Diabetes March 2000, Vol.49, 332-339. doi:https://doi.org/10.2337/diabetes.49.3.332

Interleukin-1beta-induced alteration in a beta-cell phenotype can reduce cellular sensitivity to conditions that cause necrosis but not to cytokine-induced apoptosis.

Z Ling; M Van de Casteele; D L Eizirik; D G Pipeleers

Abstract

View articletitled, Interleukin-1beta-induced alteration in a beta-cell phenotype can reduce cellular sensitivity to conditions that cause necrosis but not to cytokine-induced apoptosis.

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Topics: apoptosis , cytokine , interleukins , necrosis , pancreatic beta cell

Diabetes March 2000, Vol.49, 340-345. doi:https://doi.org/10.2337/diabetes.49.3.340

Anti-inflammatory actions of 15-deoxy-delta 12,14-prostaglandin J2 and troglitazone: evidence for heat shock-dependent and -independent inhibition of cytokine-induced inducible nitric oxide synthase expression.

L B Maggi, Jr; H Sadeghi; C Weigand; A L Scarim; M R Heitmeier; J A Corbett

Abstract

View articletitled, Anti-inflammatory actions of 15-deoxy-delta 12,14-prostaglandin J2 and troglitazone: evidence for heat shock-dependent and -independent inhibition of cytokine-induced inducible nitric oxide synthase expression.

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Topics: anti-inflammatory agents , cytokine , heat (physical force) , nitric oxide synthase , prostaglandins

Diabetes March 2000, Vol.49, 346-355. doi:https://doi.org/10.2337/diabetes.49.3.346

T-cell lines reactive to an immunodominant epitope of the tyrosine phosphatase-like autoantigen IA-2 in type 1 diabetes.

C J Hawkes; N C Schloot; J Marks; S J Willemen; J W Drijfhout; E K Mayer; M R Christie; B O Roep

Abstract

View articletitled, T-cell lines reactive to an immunodominant epitope of the tyrosine phosphatase-like autoantigen IA-2 in type 1 diabetes.

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Topics: autoantigens , diabetes mellitus, type 1 , epitopes , phosphoric monoester hydrolases , t-lymphocytes

Diabetes March 2000, Vol.49, 356-366. doi:https://doi.org/10.2337/diabetes.49.3.356

Zinc as a paracrine effector in pancreatic islet cell death.

B J Kim; Y H Kim; S Kim; J W Kim; J Y Koh; S H Oh; M K Lee; K W Kim; M S Lee

Abstract

View articletitled, Zinc as a paracrine effector in pancreatic islet cell death.

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Topics: cell death , endocrine pancreas , paracrine , zinc , streptozocin

Diabetes March 2000, Vol.49, 367-372. doi:https://doi.org/10.2337/diabetes.49.3.367

Accurate measurement of endogenous insulin secretion does not require separate assessment of C-peptide kinetics.

R M Watanabe; R N Bergman

Abstract

View articletitled, Accurate measurement of endogenous insulin secretion does not require separate assessment of C-peptide kinetics.

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Topics: c-peptide , insulin secretion , kinetics

Diabetes March 2000, Vol.49, 373-382. doi:https://doi.org/10.2337/diabetes.49.3.373

Synaptotagmin III isoform is compartmentalized in pancreatic beta-cells and has a functional role in exocytosis.

H Brown; B Meister; J Deeney; B E Corkey; S N Yang; O Larsson; C J Rhodes; S Seino; P O Berggren; G Fried

Abstract

View articletitled, Synaptotagmin III isoform is compartmentalized in pancreatic beta-cells and has a functional role in exocytosis.

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Topics: exocytosis , pancreas , protein isoforms , calcium ions , insulin

Diabetes March 2000, Vol.49, 383-391. doi:https://doi.org/10.2337/diabetes.49.3.383

Quantitative and functional characterization of muscarinic receptor subtypes in insulin-secreting cell lines and rat pancreatic islets.

T P Iismaa; E A Kerr; J R Wilson; L Carpenter; N Sims; T J Biden

Abstract

View articletitled, Quantitative and functional characterization of muscarinic receptor subtypes in insulin-secreting cell lines and rat pancreatic islets.

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Topics: endocrine pancreas , muscarinic acetylcholine receptor , pancreatic beta cell

Diabetes March 2000, Vol.49, 392-398. doi:https://doi.org/10.2337/diabetes.49.3.392

Prolonged elevation of plasma free fatty acids impairs pancreatic beta-cell function in obese nondiabetic humans but not in individuals with type 2 diabetes.

A Carpentier; S D Mittelman; R N Bergman; A Giacca; G F Lewis

Abstract

View articletitled, Prolonged elevation of plasma free fatty acids impairs pancreatic beta-cell function in obese nondiabetic humans but not in individuals with type 2 diabetes.

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Topics: diabetes mellitus, type 2 , nonesterified fatty acids , obesity , pancreas , pancreatic beta cell

Diabetes March 2000, Vol.49, 399-408. doi:https://doi.org/10.2337/diabetes.49.3.399

The extracellular calcium-sensing receptor on human beta-cells negatively modulates insulin secretion.

P E Squires; T E Harris; S J Persaud; S B Curtis; A M Buchan; P M Jones

Abstract

View articletitled, The extracellular calcium-sensing receptor on human beta-cells negatively modulates insulin secretion.

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Topics: insulin secretion , receptors, calcium-sensing

Diabetes March 2000, Vol.49, 409-417. doi:https://doi.org/10.2337/diabetes.49.3.409

Glucose modulation of insulin mRNA levels is dependent on transcription factor PDX-1 and occurs independently of changes in intracellular Ca2+.

W M Macfarlane; R M Shepherd; K E Cosgrove; R F James; M J Dunne; K Docherty

Abstract

View articletitled, Glucose modulation of insulin mRNA levels is dependent on transcription factor PDX-1 and occurs independently of changes in intracellular Ca2+.

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Topics: calcium ions , glucose , insulin , rna, messenger , transcription factor

Diabetes March 2000, Vol.49, 418-423. doi:https://doi.org/10.2337/diabetes.49.3.418

Isolation of INS-1-derived cell lines with robust ATP-sensitive K+ channel-dependent and -independent glucose-stimulated insulin secretion.

H E Hohmeier; H Mulder; G Chen; R Henkel-Rieger; M Prentki; C B Newgard

Abstract

View articletitled, Isolation of INS-1-derived cell lines with robust ATP-sensitive K+ channel-dependent and -independent glucose-stimulated insulin secretion.

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Topics: cell lines , glucose , insulin secretion

Diabetes March 2000, Vol.49, 424-430. doi:https://doi.org/10.2337/diabetes.49.3.424

Impaired leptin responsiveness in aged rats.

P J Scarpace; M Matheny; R L Moore; N Tümer

Abstract

View articletitled, Impaired leptin responsiveness in aged rats.

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Topics: leptin , rats

Diabetes March 2000, Vol.49, 431-435. doi:https://doi.org/10.2337/diabetes.49.3.431

Brain-derived neurotrophic factor regulates glucose metabolism by modulating energy balance in diabetic mice.

T Nakagawa; A Tsuchida; Y Itakura; T Nonomura; M Ono; F Hirota; T Inoue; C Nakayama; M Taiji; H Noguchi

Abstract

View articletitled, Brain-derived neurotrophic factor regulates glucose metabolism by modulating energy balance in diabetic mice.

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Topics: brain-derived neurotrophic factor , energy balance , glucose metabolism , mice

Diabetes March 2000, Vol.49, 436-444. doi:https://doi.org/10.2337/diabetes.49.3.436

Type 2 diabetes and low birth weight: the role of paternal inheritance in the association of low birth weight and diabetes.

R S Lindsay; D Dabelea; J Roumain; R L Hanson; P H Bennett; W C Knowler

Abstract

View articletitled, Type 2 diabetes and low birth weight: the role of paternal inheritance in the association of low birth weight and diabetes.

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Topics: diabetes mellitus, type 2 , low birth weight infant , paternal inheritance

Diabetes March 2000, Vol.49, 445-449. doi:https://doi.org/10.2337/diabetes.49.3.445

Renal glucose production compensates for the liver during the anhepatic phase of liver transplantation.

S E Joseph; N Heaton; D Potter; A Pernet; M A Umpleby; S A Amiel

Abstract

View articletitled, Renal glucose production compensates for the liver during the anhepatic phase of liver transplantation.

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Topics: glucose , kidney , liver , liver transplantation

Diabetes March 2000, Vol.49, 450-456. doi:https://doi.org/10.2337/diabetes.49.3.450

Dysregulation of the insulin/IGF binding protein-1 axis in transgenic mice is associated with hyperinsulinemia and glucose intolerance.

P A Crossey; J S Jones; J P Miell

Abstract

View articletitled, Dysregulation of the insulin/IGF binding protein-1 axis in transgenic mice is associated with hyperinsulinemia and glucose intolerance.

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Topics: glucose intolerance , hyperinsulinism , insulin , mice, transgenic

Diabetes March 2000, Vol.49, 457-465. doi:https://doi.org/10.2337/diabetes.49.3.457

Early glomerular macrophage recruitment in streptozotocin-induced diabetic rats.

C Sassy-Prigent; D Heudes; C Mandet; M F Bélair; O Michel; B Perdereau; J Bariéty; P Bruneval

Abstract

View articletitled, Early glomerular macrophage recruitment in streptozotocin-induced diabetic rats.

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Topics: kidney glomerulus , macrophages , rats , streptozocin

Diabetes March 2000, Vol.49, 466-475. doi:https://doi.org/10.2337/diabetes.49.3.466

Course of renal function in type 2 diabetic patients with abnormalities of albumin excretion rate.

R Nosadini; M Velussi; E Brocco; M Bruseghin; C Abaterusso; A Saller; M Dalla Vestra; A Carraro; E Bortoloso; M Sambataro; I Barzon; F Frigato; B Muollo; M Chiesura-Corona; G Pacini; B Baggio; F Piarulli; A Sfriso; P Fioretto

Abstract

View articletitled, Course of renal function in type 2 diabetic patients with abnormalities of albumin excretion rate.

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Topics: albumins , excretory function , renal function

Diabetes March 2000, Vol.49, 476-484. doi:https://doi.org/10.2337/diabetes.49.3.476

Increased levels of soluble vascular cell adhesion molecule 1 are associated with risk of cardiovascular mortality in type 2 diabetes: the Hoorn study.

A Jager; V W van Hinsbergh; P J Kostense; J J Emeis; G Nijpels; J M Dekker; R J Heine; L M Bouter; C D Stehouwer

Abstract

View articletitled, Increased levels of soluble vascular cell adhesion molecule 1 are associated with risk of cardiovascular mortality in type 2 diabetes: the Hoorn study.

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Topics: cardiovascular death , diabetes mellitus, type 2 , vascular cell adhesion molecule-1

Diabetes March 2000, Vol.49, 485-491. doi:https://doi.org/10.2337/diabetes.49.3.485

Genetic and physical mapping of a type 1 diabetes susceptibility gene (IDDM12) to a 100-kb phagemid artificial chromosome clone containing D2S72-CTLA4-D2S105 on chromosome 2q33.

M P Marron; A Zeidler; L J Raffel; S E Eckenrode; J J Yang; D I Hopkins; H J Garchon; C O Jacob; M Serrano-Rios; M T Martinez Larrad; Y Park; J F Bach; J I Rotter; M C Yang; J X She

Abstract

View articletitled, Genetic and physical mapping of a type 1 diabetes susceptibility gene (IDDM12) to a 100-kb phagemid artificial chromosome clone containing D2S72-CTLA4-D2S105 on chromosome 2q33.

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Topics: chromosomes , chromosomes, artificial , clone cells , diabetes mellitus, type 1 , genes

Diabetes March 2000, Vol.49, 492-499. doi:https://doi.org/10.2337/diabetes.49.3.492

Association of the nitric oxide synthase gene polymorphism with an increased risk for progression to diabetic nephropathy in type 2 diabetes.

S Neugebauer; T Baba; T Watanabe

Abstract

View articletitled, Association of the nitric oxide synthase gene polymorphism with an increased risk for progression to diabetic nephropathy in type 2 diabetes.

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Topics: diabetes mellitus, type 2 , diabetic nephropathy , genes , nitric oxide synthase , polymorphism

Diabetes March 2000, Vol.49, 500-503. doi:https://doi.org/10.2337/diabetes.49.3.500

Vitamin D receptor allele combinations influence genetic susceptibility to type 1 diabetes in Germans.

M A Pani; M Knapp; H Donner; J Braun; M P Baur; K H Usadel; K Badenhoop

Abstract

View articletitled, Vitamin D receptor allele combinations influence genetic susceptibility to type 1 diabetes in Germans.

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Topics: alleles , diabetes mellitus, type 1 , genetic predisposition to disease , vitamin d3 receptor

Diabetes March 2000, Vol.49, 504-507. doi:https://doi.org/10.2337/diabetes.49.3.504

Physical and genetic mapping of IDDM8 on chromosome 6q27.

D Owerbach

Abstract

View articletitled, Physical and genetic mapping of IDDM8 on chromosome 6q27.

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Topics: chromosome mapping , chromosomes , diabetes mellitus, type 1

Diabetes March 2000, Vol.49, 508-512. doi:https://doi.org/10.2337/diabetes.49.3.508

Linkage of serum insulin concentrations to chromosome 3p in Mexican Americans.

B D Mitchell; S A Cole; W C Hsueh; A G Comuzzie; J Blangero; J W MacCluer; J E Hixson

Abstract

View articletitled, Linkage of serum insulin concentrations to chromosome 3p in Mexican Americans.

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Topics: chromosomes , insulin

Diabetes March 2000, Vol.49, 513-516. doi:https://doi.org/10.2337/diabetes.49.3.513

Interleukin-6 gene polymorphism and insulin sensitivity.

J M Fernández-Real; M Broch; J Vendrell; C Gutiérrez; R Casamitjana; M Pugeat; C Richart; W Ricart

Abstract

View articletitled, Interleukin-6 gene polymorphism and insulin sensitivity.

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Topics: genes , insulin sensitivity , interleukin-6 , polymorphism

Diabetes March 2000, Vol.49, 517-520. doi:https://doi.org/10.2337/diabetes.49.3.517

A PC-1 amino acid variant (K121Q) is associated with faster progression of renal disease in patients with type 1 diabetes and albuminuria.

S De Cosmo; A Argiolas; G Miscio; S Thomas; G P Piras; R Trevisan; P C Perin; S Bacci; L Zucaro; M Margaglione; L Frittitta; A Pizzuti; V Tassi; G C Viberti; V Trischitta

Abstract

View articletitled, A PC-1 amino acid variant (K121Q) is associated with faster progression of renal disease in patients with type 1 diabetes and albuminuria.

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Topics: albuminuria , amino acids , diabetes mellitus, type 1 , kidney diseases

Diabetes March 2000, Vol.49, 521-524. doi:https://doi.org/10.2337/diabetes.49.3.521

Diverse roles of K(ATP) channels learned from Kir6.2 genetically engineered mice.

Induction of fatty acid translocase/CD36, peroxisome proliferator-activated receptor-gamma2, leptin, uncoupling proteins 2 and 3, and tumor necrosis factor-alpha gene expression in human subcutaneous fat by lipid infusion.

Insulin signaling and insulin sensitivity after exercise in human skeletal muscle.

Constitutively active mitogen-activated protein kinase kinase increases GLUT1 expression and recruits both GLUT1 and GLUT4 at the cell surface in 3T3-L1 adipocytes.

Interleukin-1beta-induced alteration in a beta-cell phenotype can reduce cellular sensitivity to conditions that cause necrosis but not to cytokine-induced apoptosis.

Anti-inflammatory actions of 15-deoxy-delta 12,14-prostaglandin J2 and troglitazone: evidence for heat shock-dependent and -independent inhibition of cytokine-induced inducible nitric oxide synthase expression.

T-cell lines reactive to an immunodominant epitope of the tyrosine phosphatase-like autoantigen IA-2 in type 1 diabetes.

Zinc as a paracrine effector in pancreatic islet cell death.

Accurate measurement of endogenous insulin secretion does not require separate assessment of C-peptide kinetics.

Synaptotagmin III isoform is compartmentalized in pancreatic beta-cells and has a functional role in exocytosis.

Quantitative and functional characterization of muscarinic receptor subtypes in insulin-secreting cell lines and rat pancreatic islets.

Prolonged elevation of plasma free fatty acids impairs pancreatic beta-cell function in obese nondiabetic humans but not in individuals with type 2 diabetes.

The extracellular calcium-sensing receptor on human beta-cells negatively modulates insulin secretion.

Glucose modulation of insulin mRNA levels is dependent on transcription factor PDX-1 and occurs independently of changes in intracellular Ca2+.

Isolation of INS-1-derived cell lines with robust ATP-sensitive K+ channel-dependent and -independent glucose-stimulated insulin secretion.

Impaired leptin responsiveness in aged rats.

Brain-derived neurotrophic factor regulates glucose metabolism by modulating energy balance in diabetic mice.

Type 2 diabetes and low birth weight: the role of paternal inheritance in the association of low birth weight and diabetes.

Renal glucose production compensates for the liver during the anhepatic phase of liver transplantation.

Dysregulation of the insulin/IGF binding protein-1 axis in transgenic mice is associated with hyperinsulinemia and glucose intolerance.

Early glomerular macrophage recruitment in streptozotocin-induced diabetic rats.

Course of renal function in type 2 diabetic patients with abnormalities of albumin excretion rate.

Increased levels of soluble vascular cell adhesion molecule 1 are associated with risk of cardiovascular mortality in type 2 diabetes: the Hoorn study.

Genetic and physical mapping of a type 1 diabetes susceptibility gene (IDDM12) to a 100-kb phagemid artificial chromosome clone containing D2S72-CTLA4-D2S105 on chromosome 2q33.

Association of the nitric oxide synthase gene polymorphism with an increased risk for progression to diabetic nephropathy in type 2 diabetes.

Vitamin D receptor allele combinations influence genetic susceptibility to type 1 diabetes in Germans.

Physical and genetic mapping of IDDM8 on chromosome 6q27.

Linkage of serum insulin concentrations to chromosome 3p in Mexican Americans.

Interleukin-6 gene polymorphism and insulin sensitivity.

A PC-1 amino acid variant (K121Q) is associated with faster progression of renal disease in patients with type 1 diabetes and albuminuria.

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