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Volume 49, Issue 5

1 May 2000

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Table of Contents

ISSN 0012-1797

EISSN 1939-327X

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Fuel selection in human skeletal muscle in insulin resistance: a reexamination.

D E Kelley; L J Mandarino

Abstract

View articletitled, Fuel selection in human skeletal muscle in insulin resistance: a reexamination.

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Diabetes May 2000, Vol.49, 677-683. doi:https://doi.org/10.2337/diabetes.49.5.677

Mice with gene disruption of both endothelial and neuronal nitric oxide synthase exhibit insulin resistance.

R R Shankar; Y Wu; H Q Shen; J S Zhu; A D Baron

Abstract

View articletitled, Mice with gene disruption of both endothelial and neuronal nitric oxide synthase exhibit insulin resistance.

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Diabetes May 2000, Vol.49, 684-687. doi:https://doi.org/10.2337/diabetes.49.5.684

Secretion of tumor necrosis factor-alpha shows a strong relationship to insulin-stimulated glucose transport in human adipose tissue.

P Löfgren; V van Harmelen; S Reynisdottir; E Näslund; M Rydén; S Rössner; P Arner

Abstract

View articletitled, Secretion of tumor necrosis factor-alpha shows a strong relationship to insulin-stimulated glucose transport in human adipose tissue.

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Diabetes May 2000, Vol.49, 688-692. doi:https://doi.org/10.2337/diabetes.49.5.688

Localization of glucokinase gene expression in the rat brain.

R M Lynch; L S Tompkins; H L Brooks; A A Dunn-Meynell; B E Levin

Abstract

View articletitled, Localization of glucokinase gene expression in the rat brain.

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Diabetes May 2000, Vol.49, 693-700. doi:https://doi.org/10.2337/diabetes.49.5.693

Effects of free fatty acid elevation on postabsorptive endogenous glucose production and gluconeogenesis in humans.

M Roden; H Stingl; V Chandramouli; W C Schumann; A Hofer; B R Landau; P Nowotny; W Waldhäusl; G I Shulman

Abstract

View articletitled, Effects of free fatty acid elevation on postabsorptive endogenous glucose production and gluconeogenesis in humans.

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Diabetes May 2000, Vol.49, 701-707. doi:https://doi.org/10.2337/diabetes.49.5.701

Acceleration of type 1 diabetes by a coxsackievirus infection requires a preexisting critical mass of autoreactive T-cells in pancreatic islets.

D V Serreze; E W Ottendorfer; T M Ellis; C J Gauntt; M A Atkinson

Abstract

View articletitled, Acceleration of type 1 diabetes by a coxsackievirus infection requires a preexisting critical mass of autoreactive T-cells in pancreatic islets.

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Diabetes May 2000, Vol.49, 708-711. doi:https://doi.org/10.2337/diabetes.49.5.708

Cerulenin, an inhibitor of protein acylation, selectively attenuates nutrient stimulation of insulin release: a study in rat pancreatic islets.

H Yajima; M Komatsu; S Yamada; S G Straub; T Kaneko; Y Sato; K Yamauchi; K Hashizume; G W Sharp; T Aizawa

Abstract

View articletitled, Cerulenin, an inhibitor of protein acylation, selectively attenuates nutrient stimulation of insulin release: a study in rat pancreatic islets.

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Diabetes May 2000, Vol.49, 712-717. doi:https://doi.org/10.2337/diabetes.49.5.712

Glucose-regulated anaplerosis and cataplerosis in pancreatic beta-cells: possible implication of a pyruvate/citrate shuttle in insulin secretion.

S Farfari; V Schulz; B Corkey; M Prentki

Abstract

View articletitled, Glucose-regulated anaplerosis and cataplerosis in pancreatic beta-cells: possible implication of a pyruvate/citrate shuttle in insulin secretion.

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Diabetes May 2000, Vol.49, 718-726. doi:https://doi.org/10.2337/diabetes.49.5.718

Cx36 preferentially connects beta-cells within pancreatic islets.

V Serre-Beinier; S Le Gurun; N Belluardo; A Trovato-Salinaro; A Charollais; J A Haefliger; D F Condorelli; P Meda

Abstract

View articletitled, Cx36 preferentially connects beta-cells within pancreatic islets.

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Diabetes May 2000, Vol.49, 727-734. doi:https://doi.org/10.2337/diabetes.49.5.727

Metformin restores insulin secretion altered by chronic exposure to free fatty acids or high glucose: a direct metformin effect on pancreatic beta-cells.

G Patanè; S Piro; A M Rabuazzo; M Anello; R Vigneri; F Purrello

Abstract

View articletitled, Metformin restores insulin secretion altered by chronic exposure to free fatty acids or high glucose: a direct metformin effect on pancreatic beta-cells.

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Diabetes May 2000, Vol.49, 735-740. doi:https://doi.org/10.2337/diabetes.49.5.735

Insulinotropic glucagon-like peptide 1 agonists stimulate expression of homeodomain protein IDX-1 and increase islet size in mouse pancreas.

D A Stoffers; T J Kieffer; M A Hussain; D J Drucker; S Bonner-Weir; J F Habener; J M Egan

Abstract

View articletitled, Insulinotropic glucagon-like peptide 1 agonists stimulate expression of homeodomain protein IDX-1 and increase islet size in mouse pancreas.

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Diabetes May 2000, Vol.49, 741-748. doi:https://doi.org/10.2337/diabetes.49.5.741

Hepatic fat content and insulin action on free fatty acids and glucose metabolism rather than insulin absorption are associated with insulin requirements during insulin therapy in type 2 diabetic patients.

L Ryysy; A M Häkkinen; T Goto; S Vehkavaara; J Westerbacka; J Halavaara; H Yki-Järvinen

Abstract

View articletitled, Hepatic fat content and insulin action on free fatty acids and glucose metabolism rather than insulin absorption are associated with insulin requirements during insulin therapy in type 2 diabetic patients.

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Diabetes May 2000, Vol.49, 749-758. doi:https://doi.org/10.2337/diabetes.49.5.749

A new thiazolidinedione, NC-2100, which is a weak PPAR-gamma activator, exhibits potent antidiabetic effects and induces uncoupling protein 1 in white adipose tissue of KKAy obese mice.

Y Fukui; S Masui; S Osada; K Umesono; K Motojima

Abstract

View articletitled, A new thiazolidinedione, NC-2100, which is a weak PPAR-gamma activator, exhibits potent antidiabetic effects and induces uncoupling protein 1 in white adipose tissue of KKAy obese mice.

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Diabetes May 2000, Vol.49, 759-767. doi:https://doi.org/10.2337/diabetes.49.5.759

Interaction between insulin sensitivity and muscle perfusion on glucose uptake in human skeletal muscle: evidence for capillary recruitment.

A D Baron; M Tarshoby; G Hook; E N Lazaridis; J Cronin; A Johnson; H O Steinberg

Abstract

View articletitled, Interaction between insulin sensitivity and muscle perfusion on glucose uptake in human skeletal muscle: evidence for capillary recruitment.

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Diabetes May 2000, Vol.49, 768-774. doi:https://doi.org/10.2337/diabetes.49.5.768

Targeted upregulation of pyruvate dehydrogenase kinase (PDK)-4 in slow-twitch skeletal muscle underlies the stable modification of the regulatory characteristics of PDK induced by high-fat feeding.

M J Holness; A Kraus; R A Harris; M C Sugden

Abstract

View articletitled, Targeted upregulation of pyruvate dehydrogenase kinase (PDK)-4 in slow-twitch skeletal muscle underlies the stable modification of the regulatory characteristics of PDK induced by high-fat feeding.

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Diabetes May 2000, Vol.49, 775-781. doi:https://doi.org/10.2337/diabetes.49.5.775

Response of pancreatic beta-cells to improved insulin sensitivity in women at high risk for type 2 diabetes.

T A Buchanan; A H Xiang; R K Peters; S L Kjos; K Berkowitz; A Marroquin; J Goico; C Ochoa; S P Azen

Abstract

View articletitled, Response of pancreatic beta-cells to improved insulin sensitivity in women at high risk for type 2 diabetes.

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Diabetes May 2000, Vol.49, 782-788. doi:https://doi.org/10.2337/diabetes.49.5.782

IGF-I treatment in adults with type 1 diabetes: effects on glucose and protein metabolism in the fasting state and during a hyperinsulinemic-euglycemic amino acid clamp.

P V Carroll; E R Christ; A M Umpleby; I Gowrie; N Jackson; S B Bowes; R Hovorka; P Croos; P H Sönksen; D L Russell-Jones

Abstract

View articletitled, IGF-I treatment in adults with type 1 diabetes: effects on glucose and protein metabolism in the fasting state and during a hyperinsulinemic-euglycemic amino acid clamp.

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Diabetes May 2000, Vol.49, 789-796. doi:https://doi.org/10.2337/diabetes.49.5.789

Rates of skeletal muscle and adipose tissue glycerol release in nonobese and obese subjects.

J Bolinder; D A Kerckhoffs; E Moberg; E Hagström-Toft; P Arner

Abstract

View articletitled, Rates of skeletal muscle and adipose tissue glycerol release in nonobese and obese subjects.

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Diabetes May 2000, Vol.49, 797-802. doi:https://doi.org/10.2337/diabetes.49.5.797

Delayed insulin transport across endothelium in insulin-resistant JCR:LA-cp rats.

T C Wascher; G Wölkart; J C Russell; F Brunner

Abstract

View articletitled, Delayed insulin transport across endothelium in insulin-resistant JCR:LA-cp rats.

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Diabetes May 2000, Vol.49, 803-809. doi:https://doi.org/10.2337/diabetes.49.5.803

Tumor necrosis factor-alpha induces hepatic insulin resistance in obese Zucker (fa/fa) rats via interaction of leukocyte antigen-related tyrosine phosphatase with focal adhesion kinase.

A T Cheung; J Wang; D Ree; J K Kolls; M Bryer-Ash

Abstract

View articletitled, Tumor necrosis factor-alpha induces hepatic insulin resistance in obese Zucker (fa/fa) rats via interaction of leukocyte antigen-related tyrosine phosphatase with focal adhesion kinase.

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Diabetes May 2000, Vol.49, 810-819. doi:https://doi.org/10.2337/diabetes.49.5.810

Presumed apoptosis and reduced arcuate nucleus neuropeptide Y and pro-opiomelanocortin mRNA in non-coma hypoglycemia.

N C Tkacs; A A Dunn-Meynell; B E Levin

Abstract

View articletitled, Presumed apoptosis and reduced arcuate nucleus neuropeptide Y and pro-opiomelanocortin mRNA in non-coma hypoglycemia.

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Diabetes May 2000, Vol.49, 820-826. doi:https://doi.org/10.2337/diabetes.49.5.820

Mechanism of troglitazone action in type 2 diabetes.

K F Petersen; M Krssak; S Inzucchi; G W Cline; S Dufour; G I Shulman

Abstract

View articletitled, Mechanism of troglitazone action in type 2 diabetes.

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Diabetes May 2000, Vol.49, 827-831. doi:https://doi.org/10.2337/diabetes.49.5.827

Genotype/phenotype relationships in HNF-4alpha/MODY1: haploinsufficiency is associated with reduced apolipoprotein (AII), apolipoprotein (CIII), lipoprotein(a), and triglyceride levels.

D Q Shih; H M Dansky; M Fleisher; G Assmann; S S Fajans; M Stoffel

Abstract

View articletitled, Genotype/phenotype relationships in HNF-4alpha/MODY1: haploinsufficiency is associated with reduced apolipoprotein (AII), apolipoprotein (CIII), lipoprotein(a), and triglyceride levels.

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Diabetes May 2000, Vol.49, 832-837. doi:https://doi.org/10.2337/diabetes.49.5.832

Differential brain responses to satiation in obese and lean men.

J F Gautier; K Chen; A D Salbe; D Bandy; R E Pratley; M Heiman; E Ravussin; E M Reiman; P A Tataranni

Abstract

View articletitled, Differential brain responses to satiation in obese and lean men.

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Diabetes May 2000, Vol.49, 838-846. doi:https://doi.org/10.2337/diabetes.49.5.838

Divergent regulation of Akt1 and Akt2 isoforms in insulin target tissues of obese Zucker rats.

Y B Kim; O D Peroni; T F Franke; B B Kahn

Abstract

View articletitled, Divergent regulation of Akt1 and Akt2 isoforms in insulin target tissues of obese Zucker rats.

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Diabetes May 2000, Vol.49, 847-856. doi:https://doi.org/10.2337/diabetes.49.5.847

Nitric oxide synthesis and isoprostane production in subjects with type 1 diabetes and normal urinary albumin excretion.

S O'Byrne; P Forte; L J Roberts, 2nd; J D Morrow; A Johnston; E Anggård; R D Leslie; N Benjamin

Abstract

View articletitled, Nitric oxide synthesis and isoprostane production in subjects with type 1 diabetes and normal urinary albumin excretion.

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Diabetes May 2000, Vol.49, 857-862. doi:https://doi.org/10.2337/diabetes.49.5.857

Glucosamine activates the plasminogen activator inhibitor 1 gene promoter through Sp1 DNA binding sites in glomerular mesangial cells.

H J Goldberg; J Scholey; I G Fantus

Abstract

View articletitled, Glucosamine activates the plasminogen activator inhibitor 1 gene promoter through Sp1 DNA binding sites in glomerular mesangial cells.

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Diabetes May 2000, Vol.49, 863-871. doi:https://doi.org/10.2337/diabetes.49.5.863

The CART gene and human obesity: mutational analysis and population genetics.

B G Challis; G S Yeo; I S Farooqi; J Luan; S Aminian; D J Halsall; J M Keogh; N J Wareham; S O'Rahilly

Abstract

View articletitled, The CART gene and human obesity: mutational analysis and population genetics.

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Diabetes May 2000, Vol.49, 872-875. doi:https://doi.org/10.2337/diabetes.49.5.872

NeuroD/BETA2 gene variability and diabetes: no associations to late-onset type 2 diabetes but an A45 allele may represent a susceptibility marker for type 1 diabetes among Danes. Danish Study Group of Diabetes in Childhood, and the Danish IDDM Epidemiology and Genetics Group.

L Hansen; J N Jensen; S Urioste; H V Petersen; F Pociot; H Eiberg; O P Kristiansen; T Hansen; P Serup; J Nerup; O Pedersen

Abstract

View articletitled, NeuroD/BETA2 gene variability and diabetes: no associations to late-onset type 2 diabetes but an A45 allele may represent a susceptibility marker for type 1 diabetes among Danes. Danish Study Group of Diabetes in Childhood, and the Danish IDDM Epidemiology and Genetics Group.

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Diabetes May 2000, Vol.49, 876-878. doi:https://doi.org/10.2337/diabetes.49.5.876

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Fuel selection in human skeletal muscle in insulin resistance: a reexamination.

Mice with gene disruption of both endothelial and neuronal nitric oxide synthase exhibit insulin resistance.

Secretion of tumor necrosis factor-alpha shows a strong relationship to insulin-stimulated glucose transport in human adipose tissue.

Localization of glucokinase gene expression in the rat brain.

Effects of free fatty acid elevation on postabsorptive endogenous glucose production and gluconeogenesis in humans.

Acceleration of type 1 diabetes by a coxsackievirus infection requires a preexisting critical mass of autoreactive T-cells in pancreatic islets.

Cerulenin, an inhibitor of protein acylation, selectively attenuates nutrient stimulation of insulin release: a study in rat pancreatic islets.

Glucose-regulated anaplerosis and cataplerosis in pancreatic beta-cells: possible implication of a pyruvate/citrate shuttle in insulin secretion.

Cx36 preferentially connects beta-cells within pancreatic islets.

Metformin restores insulin secretion altered by chronic exposure to free fatty acids or high glucose: a direct metformin effect on pancreatic beta-cells.

Insulinotropic glucagon-like peptide 1 agonists stimulate expression of homeodomain protein IDX-1 and increase islet size in mouse pancreas.

Hepatic fat content and insulin action on free fatty acids and glucose metabolism rather than insulin absorption are associated with insulin requirements during insulin therapy in type 2 diabetic patients.

A new thiazolidinedione, NC-2100, which is a weak PPAR-gamma activator, exhibits potent antidiabetic effects and induces uncoupling protein 1 in white adipose tissue of KKAy obese mice.

Interaction between insulin sensitivity and muscle perfusion on glucose uptake in human skeletal muscle: evidence for capillary recruitment.

Targeted upregulation of pyruvate dehydrogenase kinase (PDK)-4 in slow-twitch skeletal muscle underlies the stable modification of the regulatory characteristics of PDK induced by high-fat feeding.

Response of pancreatic beta-cells to improved insulin sensitivity in women at high risk for type 2 diabetes.

IGF-I treatment in adults with type 1 diabetes: effects on glucose and protein metabolism in the fasting state and during a hyperinsulinemic-euglycemic amino acid clamp.

Rates of skeletal muscle and adipose tissue glycerol release in nonobese and obese subjects.

Delayed insulin transport across endothelium in insulin-resistant JCR:LA-cp rats.

Tumor necrosis factor-alpha induces hepatic insulin resistance in obese Zucker (fa/fa) rats via interaction of leukocyte antigen-related tyrosine phosphatase with focal adhesion kinase.

Presumed apoptosis and reduced arcuate nucleus neuropeptide Y and pro-opiomelanocortin mRNA in non-coma hypoglycemia.

Mechanism of troglitazone action in type 2 diabetes.

Genotype/phenotype relationships in HNF-4alpha/MODY1: haploinsufficiency is associated with reduced apolipoprotein (AII), apolipoprotein (CIII), lipoprotein(a), and triglyceride levels.

Differential brain responses to satiation in obese and lean men.

Divergent regulation of Akt1 and Akt2 isoforms in insulin target tissues of obese Zucker rats.

Nitric oxide synthesis and isoprostane production in subjects with type 1 diabetes and normal urinary albumin excretion.

Glucosamine activates the plasminogen activator inhibitor 1 gene promoter through Sp1 DNA binding sites in glomerular mesangial cells.

The CART gene and human obesity: mutational analysis and population genetics.

NeuroD/BETA2 gene variability and diabetes: no associations to late-onset type 2 diabetes but an A45 allele may represent a susceptibility marker for type 1 diabetes among Danes. Danish Study Group of Diabetes in Childhood, and the Danish IDDM Epidemiology and Genetics Group.

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