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Volume 49, Issue 7

1 July 2000

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Table of Contents

ISSN 0012-1797

EISSN 1939-327X

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Melanin-concentrating hormone regulates leptin synthesis and secretion in rat adipocytes.

R L Bradley; E G Kokkotou; E Maratos-Flier; B Cheatham

Abstract

View articletitled, Melanin-concentrating hormone regulates leptin synthesis and secretion in rat adipocytes.

Diabetes July 2000, Vol.49, 1073-1077. doi:https://doi.org/10.2337/diabetes.49.7.1073

Fatty acid oxidation and the regulation of malonyl-CoA in human muscle.

P N Båvenholm; J Pigon; A K Saha; N B Ruderman; S Efendic

Abstract

View articletitled, Fatty acid oxidation and the regulation of malonyl-CoA in human muscle.

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Diabetes July 2000, Vol.49, 1078-1083. doi:https://doi.org/10.2337/diabetes.49.7.1078

Enhanced stimulation of glucose uptake by insulin increases exercise-stimulated glucose uptake in skeletal muscle in humans: studies using [15O]O2, [15O]H2O, [18F]fluoro-deoxy-glucose, and positron emission tomography.

P Nuutila; P Peltoniemi; V Oikonen; K Larmola; J Kemppainen; T Takala; H Sipilä; A Oksanen; U Ruotsalainen; G B Bolli; H Yki-Järvinen

Abstract

View articletitled, Enhanced stimulation of glucose uptake by insulin increases exercise-stimulated glucose uptake in skeletal muscle in humans: studies using [15O]O2, [15O]H2O, [18F]fluoro-deoxy-glucose, and positron emission tomography.

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Diabetes July 2000, Vol.49, 1084-1091. doi:https://doi.org/10.2337/diabetes.49.7.1084

Fiber type-specific expression of GLUT4 in human skeletal muscle: influence of exercise training.

J R Daugaard; J N Nielsen; S Kristiansen; J L Andersen; M Hargreaves; E A Richter

Abstract

View articletitled, Fiber type-specific expression of GLUT4 in human skeletal muscle: influence of exercise training.

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Diabetes July 2000, Vol.49, 1092-1095. doi:https://doi.org/10.2337/diabetes.49.7.1092

Glycogen synthase sensitivity to insulin and glucose-6-phosphate is mediated by both NH2- and COOH-terminal phosphorylation sites.

A V Skurat; A D Dietrich; P J Roach

Abstract

View articletitled, Glycogen synthase sensitivity to insulin and glucose-6-phosphate is mediated by both NH2- and COOH-terminal phosphorylation sites.

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Diabetes July 2000, Vol.49, 1096-1100. doi:https://doi.org/10.2337/diabetes.49.7.1096

Involvement of thyroid hormones in the effect of intracerebroventricular leptin infusion on uncoupling protein-3 expression in rat muscle.

I Cusin; J Rouru; T Visser; A G Burger; F Rohner-Jeanrenaud

Abstract

View articletitled, Involvement of thyroid hormones in the effect of intracerebroventricular leptin infusion on uncoupling protein-3 expression in rat muscle.

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Diabetes July 2000, Vol.49, 1101-1105. doi:https://doi.org/10.2337/diabetes.49.7.1101

Aberrant macrophage cytokine production is a conserved feature among autoimmune-prone mouse strains: elevated interleukin (IL)-12 and an imbalance in tumor necrosis factor-alpha and IL-10 define a unique cytokine profile in macrophages from young nonobese diabetic mice.

D G Alleva; R P Pavlovich; C Grant; S B Kaser; D I Beller

Abstract

View articletitled, Aberrant macrophage cytokine production is a conserved feature among autoimmune-prone mouse strains: elevated interleukin (IL)-12 and an imbalance in tumor necrosis factor-alpha and IL-10 define a unique cytokine profile in macrophages from young nonobese diabetic mice.

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Diabetes July 2000, Vol.49, 1106-1115. doi:https://doi.org/10.2337/diabetes.49.7.1106

Cytokines induce apoptosis in beta-cells isolated from mice lacking the inducible isoform of nitric oxide synthase (iNOS-/-).

D Liu; D Pavlovic; M C Chen; M Flodström; S Sandler; D L Eizirik

Abstract

View articletitled, Cytokines induce apoptosis in beta-cells isolated from mice lacking the inducible isoform of nitric oxide synthase (iNOS-/-).

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Diabetes July 2000, Vol.49, 1116-1122. doi:https://doi.org/10.2337/diabetes.49.7.1116

Protection of insulin-producing RINm5F cells against cytokine-mediated toxicity through overexpression of antioxidant enzymes.

S Lortz; M Tiedge; T Nachtwey; A E Karlsen; J Nerup; S Lenzen

Abstract

View articletitled, Protection of insulin-producing RINm5F cells against cytokine-mediated toxicity through overexpression of antioxidant enzymes.

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Diabetes July 2000, Vol.49, 1123-1130. doi:https://doi.org/10.2337/diabetes.49.7.1123

K(ATP) channel openers protect rat islets against the toxic effect of streptozotocin.

M Kullin; Z Li; J B Hansen; E Björk; S Sandler; F A Karlsson

Abstract

View articletitled, K(ATP) channel openers protect rat islets against the toxic effect of streptozotocin.

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Diabetes July 2000, Vol.49, 1131-1136. doi:https://doi.org/10.2337/diabetes.49.7.1131

Regulation of the diabetes-associated autoantigen IA-2 in INS-1 pancreatic beta-cells.

J Seissler; T B Nguyen; G Aust; H Steinbrenner; W A Scherbaum

Abstract

View articletitled, Regulation of the diabetes-associated autoantigen IA-2 in INS-1 pancreatic beta-cells.

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Diabetes July 2000, Vol.49, 1137-1141. doi:https://doi.org/10.2337/diabetes.49.7.1137

Activating transcription factor-2 is a positive regulator in CaM kinase IV-induced human insulin gene expression.

N Ban; Y Yamada; Y Someya; Y Ihara; T Adachi; A Kubota; R Watanabe; A Kuroe; A Inada; K Miyawaki; Y Sunaga; Z P Shen; T Iwakura; K Tsukiyama; S Toyokuni; K Tsuda; Y Seino

Abstract

View articletitled, Activating transcription factor-2 is a positive regulator in CaM kinase IV-induced human insulin gene expression.

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Diabetes July 2000, Vol.49, 1142-1148. doi:https://doi.org/10.2337/diabetes.49.7.1142

Acute overexpression of lactate dehydrogenase-A perturbs beta-cell mitochondrial metabolism and insulin secretion.

E K Ainscow; C Zhao; G A Rutter

Abstract

View articletitled, Acute overexpression of lactate dehydrogenase-A perturbs beta-cell mitochondrial metabolism and insulin secretion.

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Diabetes July 2000, Vol.49, 1149-1155. doi:https://doi.org/10.2337/diabetes.49.7.1149

Glucagon-like peptide 1 stimulates insulin gene promoter activity by protein kinase A-independent activation of the rat insulin I gene cAMP response element.

G Skoglund; M A Hussain; G G Holz

Abstract

View articletitled, Glucagon-like peptide 1 stimulates insulin gene promoter activity by protein kinase A-independent activation of the rat insulin I gene cAMP response element.

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Diabetes July 2000, Vol.49, 1156-1164. doi:https://doi.org/10.2337/diabetes.49.7.1156

Induction of PEPCK gene expression in insulinopenia in rat small intestine.

F Rajas; M Croset; C Zitoun; S Montano; G Mithieux

Abstract

View articletitled, Induction of PEPCK gene expression in insulinopenia in rat small intestine.

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Diabetes July 2000, Vol.49, 1165-1168. doi:https://doi.org/10.2337/diabetes.49.7.1165

Decreased insulin responsiveness of glucose uptake in cultured human skeletal muscle cells from insulin-resistant nondiabetic relatives of type 2 diabetic families.

S Jackson; S M Bagstaff; S Lynn; S J Yeaman; D M Turnbull; M Walker

Abstract

View articletitled, Decreased insulin responsiveness of glucose uptake in cultured human skeletal muscle cells from insulin-resistant nondiabetic relatives of type 2 diabetic families.

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Diabetes July 2000, Vol.49, 1169-1177. doi:https://doi.org/10.2337/diabetes.49.7.1169

Muscle glucose uptake is effectively activated by ischemia in type 2 diabetic subjects.

M Niklasson; A Holmäng; M Sjöstrand; L Strindberg; P Lönnroth

Abstract

View articletitled, Muscle glucose uptake is effectively activated by ischemia in type 2 diabetic subjects.

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Diabetes July 2000, Vol.49, 1178-1185. doi:https://doi.org/10.2337/diabetes.49.7.1178

Renal substrate metabolism and gluconeogenesis during hypoglycemia in humans.

E Cersosimo; P Garlick; J Ferretti

Abstract

View articletitled, Renal substrate metabolism and gluconeogenesis during hypoglycemia in humans.

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Diabetes July 2000, Vol.49, 1186-1193. doi:https://doi.org/10.2337/diabetes.49.7.1186

The IR1152 mutant insulin receptor selectively impairs insulin action in skeletal muscle but not in liver.

M Caruso; C Miele; A Oliva; G Condorelli; F Oriente; G Riccardi; B Capaldo; F Fiory; D Accili; P Formisano; F Beguinot

Abstract

View articletitled, The IR1152 mutant insulin receptor selectively impairs insulin action in skeletal muscle but not in liver.

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Diabetes July 2000, Vol.49, 1194-1202. doi:https://doi.org/10.2337/diabetes.49.7.1194

Transient effects of long-term leptin supplementation in the prevention of diet-induced obesity in mice.

R S Surwit; C L Edwards; S Murthy; A E Petro

Abstract

View articletitled, Transient effects of long-term leptin supplementation in the prevention of diet-induced obesity in mice.

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Diabetes July 2000, Vol.49, 1203-1208. doi:https://doi.org/10.2337/diabetes.49.7.1203

Glucose-mediated glucose disposal in insulin-resistant normoglycemic relatives of type 2 diabetic patients.

J E Henriksen; K Levin; P Thye-Rønn; F Alford; O Hother-Nielsen; J J Holst; H Beck-Nielsen

Abstract

View articletitled, Glucose-mediated glucose disposal in insulin-resistant normoglycemic relatives of type 2 diabetic patients.

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Diabetes July 2000, Vol.49, 1209-1218. doi:https://doi.org/10.2337/diabetes.49.7.1209

Obesity is associated with a decreased leptin transport across the blood-brain barrier in rats.

B Burguera; M E Couce; G L Curran; M D Jensen; R V Lloyd; M P Cleary; J F Poduslo

Abstract

View articletitled, Obesity is associated with a decreased leptin transport across the blood-brain barrier in rats.

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Diabetes July 2000, Vol.49, 1219-1223. doi:https://doi.org/10.2337/diabetes.49.7.1219

Impaired expression of the uncoupling protein-3 gene in skeletal muscle during lactation: fibrates and troglitazone reverse lactation-induced downregulation of the uncoupling protein-3 gene.

N Pedraza; G Solanes; M C Carmona; R Iglesias; O Viñas; T Mampel; M Vazquez; M Giralt; F Villarroya

Abstract

View articletitled, Impaired expression of the uncoupling protein-3 gene in skeletal muscle during lactation: fibrates and troglitazone reverse lactation-induced downregulation of the uncoupling protein-3 gene.

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Diabetes July 2000, Vol.49, 1224-1230. doi:https://doi.org/10.2337/diabetes.49.7.1224

Free fatty acid elevation impairs insulin-mediated vasodilation and nitric oxide production.

H O Steinberg; G Paradisi; G Hook; K Crowder; J Cronin; A D Baron

Abstract

View articletitled, Free fatty acid elevation impairs insulin-mediated vasodilation and nitric oxide production.

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Diabetes July 2000, Vol.49, 1231-1238. doi:https://doi.org/10.2337/diabetes.49.7.1231

Induction of endothelin-1 expression by glucose: an effect of protein kinase C activation.

J Y Park; N Takahara; A Gabriele; E Chou; K Naruse; K Suzuma; T Yamauchi; S W Ha; M Meier; C J Rhodes; G L King

Abstract

View articletitled, Induction of endothelin-1 expression by glucose: an effect of protein kinase C activation.

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Diabetes July 2000, Vol.49, 1239-1248. doi:https://doi.org/10.2337/diabetes.49.7.1239

The diabetic milieu modulates the advanced glycation end product-receptor complex in the mesangium by inducing or upregulating galectin-3 expression.

G Pugliese; F Pricci; G Leto; L Amadio; C Iacobini; G Romeo; L Lenti; P Sale; R Gradini; F T Liu; U Di Mario

Abstract

View articletitled, The diabetic milieu modulates the advanced glycation end product-receptor complex in the mesangium by inducing or upregulating galectin-3 expression.

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Diabetes July 2000, Vol.49, 1249-1257. doi:https://doi.org/10.2337/diabetes.49.7.1249

Increased circulating nitric oxide in young patients with type 1 diabetes and persistent microalbuminuria: relation to glomerular hyperfiltration.

F Chiarelli; F Cipollone; F Romano; S Tumini; F Costantini; L di Ricco; M Pomilio; S D Pierdomenico; M Marini; F Cuccurullo; A Mezzetti

Abstract

View articletitled, Increased circulating nitric oxide in young patients with type 1 diabetes and persistent microalbuminuria: relation to glomerular hyperfiltration.

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Diabetes July 2000, Vol.49, 1258-1263. doi:https://doi.org/10.2337/diabetes.49.7.1258

Naturally occurring amino acid substitutions at Arg1174 in the human insulin receptor result in differential effects on receptor biosynthesis and hybrid formation, leading to discordant clinical phenotypes.

H Rau; M Kocova; S O'Rahilly; J P Whitehead

Abstract

View articletitled, Naturally occurring amino acid substitutions at Arg1174 in the human insulin receptor result in differential effects on receptor biosynthesis and hybrid formation, leading to discordant clinical phenotypes.

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Diabetes July 2000, Vol.49, 1264-1268. doi:https://doi.org/10.2337/diabetes.49.7.1264

A new mitochondrial DNA mutation at 14577 T/C is probably a major pathogenic mutation for maternally inherited type 2 diabetes.

M Tawata; J I Hayashi; K Isobe; E Ohkubo; M Ohtaka; J Chen; K Aida; T Onaya

Abstract

View articletitled, A new mitochondrial DNA mutation at 14577 T/C is probably a major pathogenic mutation for maternally inherited type 2 diabetes.

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Diabetes July 2000, Vol.49, 1269-1272. doi:https://doi.org/10.2337/diabetes.49.7.1269

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Melanin-concentrating hormone regulates leptin synthesis and secretion in rat adipocytes.

Fatty acid oxidation and the regulation of malonyl-CoA in human muscle.

Enhanced stimulation of glucose uptake by insulin increases exercise-stimulated glucose uptake in skeletal muscle in humans: studies using [15O]O2, [15O]H2O, [18F]fluoro-deoxy-glucose, and positron emission tomography.

Fiber type-specific expression of GLUT4 in human skeletal muscle: influence of exercise training.

Glycogen synthase sensitivity to insulin and glucose-6-phosphate is mediated by both NH2- and COOH-terminal phosphorylation sites.

Involvement of thyroid hormones in the effect of intracerebroventricular leptin infusion on uncoupling protein-3 expression in rat muscle.

Aberrant macrophage cytokine production is a conserved feature among autoimmune-prone mouse strains: elevated interleukin (IL)-12 and an imbalance in tumor necrosis factor-alpha and IL-10 define a unique cytokine profile in macrophages from young nonobese diabetic mice.

Cytokines induce apoptosis in beta-cells isolated from mice lacking the inducible isoform of nitric oxide synthase (iNOS-/-).

Protection of insulin-producing RINm5F cells against cytokine-mediated toxicity through overexpression of antioxidant enzymes.

K(ATP) channel openers protect rat islets against the toxic effect of streptozotocin.

Regulation of the diabetes-associated autoantigen IA-2 in INS-1 pancreatic beta-cells.

Activating transcription factor-2 is a positive regulator in CaM kinase IV-induced human insulin gene expression.

Acute overexpression of lactate dehydrogenase-A perturbs beta-cell mitochondrial metabolism and insulin secretion.

Glucagon-like peptide 1 stimulates insulin gene promoter activity by protein kinase A-independent activation of the rat insulin I gene cAMP response element.

Induction of PEPCK gene expression in insulinopenia in rat small intestine.

Decreased insulin responsiveness of glucose uptake in cultured human skeletal muscle cells from insulin-resistant nondiabetic relatives of type 2 diabetic families.

Muscle glucose uptake is effectively activated by ischemia in type 2 diabetic subjects.

Renal substrate metabolism and gluconeogenesis during hypoglycemia in humans.

The IR1152 mutant insulin receptor selectively impairs insulin action in skeletal muscle but not in liver.

Transient effects of long-term leptin supplementation in the prevention of diet-induced obesity in mice.

Glucose-mediated glucose disposal in insulin-resistant normoglycemic relatives of type 2 diabetic patients.

Obesity is associated with a decreased leptin transport across the blood-brain barrier in rats.

Impaired expression of the uncoupling protein-3 gene in skeletal muscle during lactation: fibrates and troglitazone reverse lactation-induced downregulation of the uncoupling protein-3 gene.

Free fatty acid elevation impairs insulin-mediated vasodilation and nitric oxide production.

Induction of endothelin-1 expression by glucose: an effect of protein kinase C activation.

The diabetic milieu modulates the advanced glycation end product-receptor complex in the mesangium by inducing or upregulating galectin-3 expression.

Increased circulating nitric oxide in young patients with type 1 diabetes and persistent microalbuminuria: relation to glomerular hyperfiltration.

Naturally occurring amino acid substitutions at Arg1174 in the human insulin receptor result in differential effects on receptor biosynthesis and hybrid formation, leading to discordant clinical phenotypes.

A new mitochondrial DNA mutation at 14577 T/C is probably a major pathogenic mutation for maternally inherited type 2 diabetes.

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