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Issues
Perspectives in Diabetes
Glucose Sensing in Pancreatic β-Cells: A Model for the Study of Other Glucose-Regulated Cells in Gut, Pancreas, and Hypothalamus
Topics:
glucose
,
hypothalamus
,
pancreas
,
neurons
,
insulin
Diabetes January 2001, Vol.50, 1-11. doi:https://doi.org/10.2337/diabetes.50.1.1
Chronic Treatment With 5-Aminoimidazole-4-Carboxamide-1-β-D-Ribofuranoside Increases Insulin-Stimulated Glucose Uptake and GLUT4 Translocation in Rat Skeletal Muscles in a Fiber Type—Specific Manner
Esben S. Buhl; Niels Jessen; Ole Schmitz; Steen B. Pedersen; Oluf Pedersen; Geoffrey D. Holman; Sten Lund
Topics:
aica ribonucleotide
,
glucose uptake
,
insulin
,
skeletal muscles
,
translocation (genetics)
Diabetes January 2001, Vol.50, 12-17. doi:https://doi.org/10.2337/diabetes.50.1.12
Effect of Oral Creatine Supplementation on Human Muscle GLUT4 Protein Content After Immobilization
Topics:
creatine
,
glut-4 protein
,
immobilization
,
rehabilitation
,
glycogen
Diabetes January 2001, Vol.50, 18-23. doi:https://doi.org/10.2337/diabetes.50.1.18
The Stimulation-Induced Increase in Skeletal Muscle Glycogen Synthase Content Is Impaired in Carriers of the Glycogen Synthase XbaI Gene Polymorphism
Topics:
genes
,
glycogen (starch) synthase
,
neuromuscular electrical stimulation
,
polymorphism
,
skeletal muscles
Diabetes January 2001, Vol.50, 195-198. doi:https://doi.org/10.2337/diabetes.50.1.195
Evidence That Insulin is Imprinted in the Human Yolk Sac
Gudrun E. Moore; Sayeda N. Abu-Amero; Gill Bell; Emma L. Wakeling; Amanda Kingsnorth; Philip Stanier; Eric Jauniaux; Simon T. Bennett
Topics:
insulin
,
insulin-like growth factor ii
,
polymerase chain reaction
,
yolk sac
,
dna, complementary
Diabetes January 2001, Vol.50, 199-203. doi:https://doi.org/10.2337/diabetes.50.1.199
Type 2 Diabetes Locus on 12q15: Further Mapping and Mutation Screening of Two Candidate Genes
Topics:
candidate disease gene
,
diabetes mellitus, type 2
,
mutation
,
screening
,
genes
Diabetes January 2001, Vol.50, 204-208. doi:https://doi.org/10.2337/diabetes.50.1.204
Metabolism and Signal Transduction
Serine/Threonine Phosphorylation of IRS-1 Triggers Its Degradation: Possible Regulation by Tyrosine Phosphorylation
Topics:
catabolism
,
insulin
,
irs1 protein, human
,
okadaic acid
,
phosphorylation
Diabetes January 2001, Vol.50, 24-31. doi:https://doi.org/10.2337/diabetes.50.1.24
Physiological Differences in Insulin-Like Growth Factor Binding Protein-1 (IGFBP-1) Phosphorylation in IGFBP-1 Transgenic Mice
Topics:
insulin-like growth factor i
,
insulin-like growth-factor binding protein 1
,
phosphorylation
,
mice
,
mice, transgenic
Diabetes January 2001, Vol.50, 32-38. doi:https://doi.org/10.2337/diabetes.50.1.32
Immunology and Transplantation
Variable Effects of Transgenic c-Maf on Autoimmune Diabetes
Mary E. Pauza; Andrea Nguyen; Tom Wolfe; I-Cheng Ho; Laurie H. Glimcher; Matthias von Herrath; David Lo
Topics:
animals, transgenic
,
autoimmunity
,
cytokine
,
lymphocytic choriomeningitis virus
,
mice
Diabetes January 2001, Vol.50, 39-46. doi:https://doi.org/10.2337/diabetes.50.1.39
Prevention of Diabetes for up to 13 Years by Autoislet Transplantation After Pancreatectomy for Chronic Pancreatitis
Topics:
diabetes prevention
,
insulin
,
pancreatectomy
,
pancreatitis, chronic
,
transplantation
Diabetes January 2001, Vol.50, 47-50. doi:https://doi.org/10.2337/diabetes.50.1.47
Islet Studies
Amplitude Modulation of Pulsatile Insulin Secretion by Intrapancreatic Ganglion Neurons
Topics:
ganglia
,
glucose
,
insulin
,
insulin secretion
,
neurons
Diabetes January 2001, Vol.50, 51-55. doi:https://doi.org/10.2337/diabetes.50.1.51
Glucagon-Like Peptide 1 Stimulates Lipolysis in Clonal Pancreatic β-Cells (HIT)
Gordon C. Yaney; Vildan N. Civelek; Ann-Marie Richard; Joseph S. Dillon; Jude T. Deeney; James A. Hamilton; Helen M. Korchak; Keith Tornheim; Barbara E. Corkey; Aubrey E. Boyd, III
Topics:
glucagon-like peptide 1
,
glucose
,
lipolysis
,
pancreas
,
cyclic amp
Diabetes January 2001, Vol.50, 56-62. doi:https://doi.org/10.2337/diabetes.50.1.56
A Genetic Defect in β-Cell Gene Expression Segregates Independently From the fa Locus in the ZDF Rat
Topics:
fetus
,
homozygote
,
insulin
,
rats
,
heterozygote
Diabetes January 2001, Vol.50, 63-68. doi:https://doi.org/10.2337/diabetes.50.1.63
Distinct Effects of Saturated and Monounsaturated Fatty Acids on β-Cell Turnover and Function
Topics:
apoptosis
,
ceramides
,
cytochrome c
,
glucose
,
monounsaturated fatty acids
Diabetes January 2001, Vol.50, 69-76. doi:https://doi.org/10.2337/diabetes.50.1.69
Cell-Permeable Peptide Inhibitors of JNK: Novel Blockers of β-Cell Death
Topics:
peptides
Diabetes January 2001, Vol.50, 77-82. doi:https://doi.org/10.2337/diabetes.50.1.77
Pathophysiology
Decreased In Situ Insulin Receptor Dephosphorylation in Hyperglycemia-Induced Insulin Resistance in Rat Adipocytes
Topics:
adipocytes
,
insulin
,
insulin receptor
,
insulin resistance
,
antibodies
Diabetes January 2001, Vol.50, 83-90. doi:https://doi.org/10.2337/diabetes.50.1.83
Identification of an Interactive Effect of β3- and α2b-Adrenoceptor Gene Polymorphisms on Fat Mass in Caucasian Women
Isabelle J. Dionne; Amy N. Turner; André Tchernof; Toni I. Pollin; Dionyssia Avrithi; Daniel Gray; Alan R. Shuldiner; Eric T. Poehlman
Topics:
adrenergic receptor
,
energy intake
,
genes
,
obesity
,
phenotype
Diabetes January 2001, Vol.50, 91-95. doi:https://doi.org/10.2337/diabetes.50.1.91
The Protein-Retaining Effects of Growth Hormone During Fasting Involve Inhibition of Muscle-Protein Breakdown
Helene Nørrelund; K. Sreekumaran Nair; Jens Otto Lunde Jørgensen; Jens Sandahl Christiansen; Niels Møller
Topics:
fasting
,
muscle proteins
,
phenylalanine
,
somatropin
,
urea
Diabetes January 2001, Vol.50, 96-104. doi:https://doi.org/10.2337/diabetes.50.1.96
Hypoglycemia Activates Orexin Neurons and Selectively Increases Hypothalamic Orexin-B Levels: Responses Inhibited by Feeding and Possibly Mediated by the Nucleus of the Solitary Tract
Xue J. Cai; Martyn L. Evans; Carolyn A. Lister; Ron A. Leslie; Jonathan R. S. Arch; Shelagh Wilson; Gareth Williams
Topics:
hypoglycemia
,
hypoglycemic agents
,
hypothalamus
,
neurons
,
orexins
Diabetes January 2001, Vol.50, 105-112. doi:https://doi.org/10.2337/diabetes.50.1.105
Mechanism of Amelioration of Insulin Resistance by β3-Adrenoceptor Agonist AJ-9677 in the KK-Ay/Ta Diabetic Obese Mouse Model
Hiroshi Kato; Mayumi Ohue; Kaori Kato; Akinori Nomura; Kaoru Toyosawa; Yasuji Furutani; Satoshi Kimura; Takashi Kadowaki
Topics:
adipocytes
,
adipose tissue
,
adrenergic receptor
,
agonists
,
epididymis
Diabetes January 2001, Vol.50, 113-122. doi:https://doi.org/10.2337/diabetes.50.1.113
Prolonged Inhibition of Muscle Carnitine Palmitoyltransferase-1 Promotes Intramyocellular Lipid Accumulation and Insulin Resistance in Rats
Robert L. Dobbins; Lidia S. Szczepaniak; Brandon Bentley; Victoria Esser; Jeffrey Myhill; J. Denis McGarry
Topics:
carnitine o-palmitoyltransferase
,
diet
,
glucose
,
insulin resistance
,
lipids
Diabetes January 2001, Vol.50, 123-130. doi:https://doi.org/10.2337/diabetes.50.1.123
Effects of Tungstate, a New Potential Oral Antidiabetic Agent, in Zucker Diabetic Fatty Rats
María Carmen Muñoz; Albert Barberà; Jorge Domínguez; Josefa Fernàndez-Alvarez; Ramon Gomis; Joan J. Guinovart
Topics:
glucose
,
rats
,
insulin
,
liver
,
antidiabetics
Diabetes January 2001, Vol.50, 131-138. doi:https://doi.org/10.2337/diabetes.50.1.131
Exercise-Stimulated Glucose Turnover in the Rat Is Impaired by Glucosamine Infusion
Topics:
glucosamine
,
glucose
,
infusion procedures
,
insulin
,
hyperglycemia
Diabetes January 2001, Vol.50, 139-142. doi:https://doi.org/10.2337/diabetes.50.1.139
Expression and Role of Bcl-2 in Rat Blastocysts Exposed to High D-Glucose
Serge Pampfer; Sabine Cordi; Ivo Vanderheyden; Patrick Van Der Smissen; Pierre J. Courtoy; Anne Van Cauwenberge; Henri Alexandre; Isabelle Donnay; René De Hertogh
Topics:
bcl2 gene
,
embryo
,
glucose
,
rna, messenger
,
oligodeoxyribonucleotides, antisense
Diabetes January 2001, Vol.50, 143-149. doi:https://doi.org/10.2337/diabetes.50.1.143
Oral Glucose Tolerance Test Minimal Model Indexes of β-Cell Function and Insulin Sensitivity
Topics:
c-peptide
,
glucose
,
insulin
,
insulin sensitivity
,
oral glucose tolerance test
Diabetes January 2001, Vol.50, 150-158. doi:https://doi.org/10.2337/diabetes.50.1.150
Complications
Obesity and Body Fat Distribution Induce Endothelial Dysfunction by Oxidative Stress: Protective Effect of Vitamin C
Francesco Perticone; Roberto Ceravolo; Mafalda Candigliota; Giorgio Ventura; Saverio Iacopino; Flora Sinopoli; Pier L. Mattioli
Topics:
acetylcholine
,
ascorbic acid
,
body fat distribution
,
endothelial dysfunction
,
endothelium
Diabetes January 2001, Vol.50, 159-165. doi:https://doi.org/10.2337/diabetes.50.1.159
Reduced Vasorelaxant Effect of Carbon Monoxide in Diabetes and the Underlying Mechanisms
Topics:
calcium channels
,
carbon monoxide
,
cyclic gmp
,
glucose
,
rats
Diabetes January 2001, Vol.50, 166-174. doi:https://doi.org/10.2337/diabetes.50.1.166
IGF-I mRNA and Signaling in the Diabetic Retina
Topics:
insulin-like growth factor i
,
rats
,
retina
,
rna, messenger
,
signal transduction
Diabetes January 2001, Vol.50, 175-183. doi:https://doi.org/10.2337/diabetes.50.1.175
Genetics
Suggestive Evidence for Association of Human Chromosome 18q12-q21 and Its Orthologue on Rat and Mouse Chromosome 18 With Several Autoimmune Diseases
Tony R. Merriman; Heather J. Cordell; Iain A. Eaves; Patrick A. Danoy; Francesca Coraddu; Rachael Barber; Francesco Cucca; Simon Broadley; Stephen Sawcer; Alastair Compston; Paul Wordsworth; Jane Shatford; Steve Laval; Johan Jirholt; Rikard Holmdahl; Argyrios N. Theofilopoulos; Dwight H. Kono; Jaakko Tuomilehto; Eva Tuomilehto-Wolf; Raffaella Buzzetti; Maria Giovanna Marrosu; Dag E. Undlien; Kjersti S. Rønningen; C. Ionesco-Tirgoviste; Julian P. Shield; Fleming Pociot; Jorn Nerup; Chaim O. Jacob; Constantin Polychronakos; Steve C. Bain; John A. Todd
Topics:
autoimmune diseases
,
autoimmunity
,
chromosomes
,
chromosomes, human
,
chromosomes, human, pair 18
Diabetes January 2001, Vol.50, 184-194. doi:https://doi.org/10.2337/diabetes.50.1.184
