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Issues
1 October 2001
ISSN 0012-1797
EISSN 1939-327X
Perspectives in Diabetes
Gene and Cell-Replacement Therapy in the Treatment of Type 1 Diabetes: How High Must the Standards Be Set?
Topics:
insulin
,
glucose
,
diabetes mellitus, type 1
,
bodily secretions
,
genes
Diabetes October 2001, Vol.50, 2181-2191. doi:https://doi.org/10.2337/diabetes.50.10.2181
Rapid Publications
Insulin Activates ATP-Sensitive K+ Channels in Pancreatic β-Cells Through a Phosphatidylinositol 3-Kinase–Dependent Pathway
Topics:
insulin
,
glucose
,
1-phosphatidylinositol 3-kinase
Diabetes October 2001, Vol.50, 2192-2198. doi:https://doi.org/10.2337/diabetes.50.10.2192
Resistin / Fizz3 Expression in Relation to Obesity and Peroxisome Proliferator–Activated Receptor-γ Action in Humans
David B. Savage; Ciaran P. Sewter; Ellen S. Klenk; David G. Segal; Antonio Vidal-Puig; Robert V. Considine; Stephen O’Rahilly
Topics:
obesity
,
resistin
,
rna, messenger
,
peroxisome
,
peroxisome proliferator-activated receptors
Diabetes October 2001, Vol.50, 2199-2202. doi:https://doi.org/10.2337/diabetes.50.10.2199
Metabolism and Signal Transduction
The Effect of Insulin on In Vivo Cerebral Glucose Concentrations and Rates of Glucose Transport/Metabolism in Humans
Topics:
brain
,
glucose
,
insulin
,
glucose transport
,
metabolism
Diabetes October 2001, Vol.50, 2203-2209. doi:https://doi.org/10.2337/diabetes.50.10.2203
A Role for Protein Phosphatase 2A–Like Activity, but Not Atypical Protein Kinase Cζ, in the Inhibition of Protein Kinase B/Akt and Glycogen Synthesis by Palmitate
Topics:
insulin
,
palmitates
,
phosphotransferases
,
protein phosphatase
,
skeletal myocytes
Diabetes October 2001, Vol.50, 2210-2218. doi:https://doi.org/10.2337/diabetes.50.10.2210
Immunology and Transplantation
Inhibition of Cytokine-Induced NF-κB Activation by Adenovirus-Mediated Expression of a NF-κB Super-Repressor Prevents β-Cell Apoptosis
Harry Heimberg; Yves Heremans; Christian Jobin; Ruth Leemans; Alessandra K. Cardozo; Martine Darville; Décio L. Eizirik
Topics:
adenoviruses
,
cytokine
,
apoptosis
Diabetes October 2001, Vol.50, 2219-2224. doi:https://doi.org/10.2337/diabetes.50.10.2219
Islet Studies
The Expression of Hormone-Sensitive Lipase in Clonal β-Cells and Rat Islets Is Induced by Long-Term Exposure to High Glucose
Topics:
glucose
,
rna, messenger
Diabetes October 2001, Vol.50, 2225-2230. doi:https://doi.org/10.2337/diabetes.50.10.2225
Noninvasive In Vivo Measurement of β-Cell Mass in Mouse Model of Diabetes
Topics:
antibodies
,
mice
,
nuclear medicine imaging
,
pancreas
,
diagnostic imaging
Diabetes October 2001, Vol.50, 2231-2236. doi:https://doi.org/10.2337/diabetes.50.10.2231
Protein Kinase Cζ Activation Mediates Glucagon-Like Peptide-1–Induced Pancreatic β-Cell Proliferation
Topics:
glucagon-like peptide 1
,
mitogen-activated protein kinase p38
,
phosphotransferases
,
thymidine
,
glucose
Diabetes October 2001, Vol.50, 2237-2243. doi:https://doi.org/10.2337/diabetes.50.10.2237
Phosphorylation-Dependent Nucleocytoplasmic Shuttling of Pancreatic Duodenal Homeobox-1
Topics:
glucose
,
insulin
,
nucleoplasm
,
antibodies
,
pancreas
Diabetes October 2001, Vol.50, 2244-2252. doi:https://doi.org/10.2337/diabetes.50.10.2244
Structural Basis for the Interference Between Nicorandil and Sulfonylurea Action
Topics:
nicorandil
,
nucleotides
,
sulfonylurea compounds
Diabetes October 2001, Vol.50, 2253-2259. doi:https://doi.org/10.2337/diabetes.50.10.2253
Inducible and Reversible β-Cell Autoimmunity and Hyperplasia in Transgenic Mice Expressing a Conditional Oncogene
Topics:
apoptosis
,
autoimmunity
,
hyperplasia
,
mice
,
mice, transgenic
Diabetes October 2001, Vol.50, 2260-2267. doi:https://doi.org/10.2337/diabetes.50.10.2260
Pathophysiology
Effects of Leptin Deficiency and Short-Term Repletion on Hepatic Gene Expression in Genetically Obese Mice
Topics:
genes
,
leptin
,
liver
,
mice
,
mice, obese
Diabetes October 2001, Vol.50, 2268-2278. doi:https://doi.org/10.2337/diabetes.50.10.2268
Intrauterine Growth Retardation Leads to the Development of Type 2 Diabetes in the Rat
Topics:
diabetes mellitus, type 2
,
fetal growth retardation
,
glucose
,
insulin
,
rats
Diabetes October 2001, Vol.50, 2279-2286. doi:https://doi.org/10.2337/diabetes.50.10.2279
Phenotypic Correction of Diabetic Mice by Adenovirus-Mediated Glucokinase Expression
Urvi J. Desai; Eric D. Slosberg; Brian R. Boettcher; Shari L. Caplan; Barbara Fanelli; Zouhair Stephan; Vicky J. Gunther; Michael Kaleko; Sheila Connelly
Topics:
adenoviruses
,
heart failure
,
insulin
,
liver
,
mice
Diabetes October 2001, Vol.50, 2287-2295. doi:https://doi.org/10.2337/diabetes.50.10.2287
Troglitazone Not Only Increases GLUT4 but Also Induces Its Translocation in Rat Adipocytes
Mitsuyo Shintani; Haruo Nishimura; Shin Yonemitsu; Yoshihiro Ogawa; Tatsuya Hayashi; Kiminori Hosoda; Gen Inoue; Kazuwa Nakao
Topics:
adipocytes
,
translocation (genetics)
,
troglitazone
,
insulin
Diabetes October 2001, Vol.50, 2296-2300. doi:https://doi.org/10.2337/diabetes.50.10.2296
Pharmacological Antilipolysis Restores Insulin Sensitivity During Growth Hormone Exposure
Topics:
glucose
,
glucose metabolism
,
insulin
,
insulin sensitivity
,
lipids
Diabetes October 2001, Vol.50, 2301-2308. doi:https://doi.org/10.2337/diabetes.50.10.2301
Direct Thiazolidinedione Action on Isolated Rat Skeletal Muscle Fuel Handling Is Independent of Peroxisome Proliferator–Activated Receptor-γ−Mediated Changes in Gene Expression
Barbara Brunmair; Florian Gras; Susanne Neschen; Michael Roden; Ludwig Wagner; Werner Waldhäusl; Clemens Fürnsinn
Topics:
insulin
,
thiazolidinedione
,
troglitazone
,
carbon dioxide
,
palmitates
Diabetes October 2001, Vol.50, 2309-2315. doi:https://doi.org/10.2337/diabetes.50.10.2309
Thiazolidinedione Treatment Prevents Free Fatty Acid–Induced Insulin Resistance in Male Wistar Rats
Topics:
insulin
,
insulin resistance
,
thiazolidinedione
,
nonesterified fatty acids
,
intravenous fat emulsions
Diabetes October 2001, Vol.50, 2316-2322. doi:https://doi.org/10.2337/diabetes.50.10.2316
Small Molecule Insulin Receptor Activators Potentiate Insulin Action in Insulin-Resistant Cells
Ming Li; Jack F. Youngren; Vara Prasad Manchem; Michael Kozlowski; Bei B. Zhang; Betty A. Maddux; Ira D. Goldfine
Diabetes October 2001, Vol.50, 2323-2328. doi:https://doi.org/10.2337/diabetes.50.10.2323
Changes in Regional Brain 18F-Fluorodeoxyglucose Uptake at Hypoglycemia in Type 1 Diabetic Men Associated With Hypoglycemia Unawareness and Counter-Regulatory Failure
Topics:
blood glucose normal
,
brain
,
fluorodeoxyglucose f18
,
hypoglycemia
,
glucose
Diabetes October 2001, Vol.50, 2329-2366. doi:https://doi.org/10.2337/diabetes.50.10.2329
Intramyocellular Lipid Is Associated With Resistance to In Vivo Insulin Actions on Glucose Uptake, Antilipolysis, and Early Insulin Signaling Pathways in Human Skeletal Muscle
Antti Virkamäki; Elena Korsheninnikova; Anneli Seppälä-Lindroos; Satu Vehkavaara; Takashi Goto; Juha Halavaara; Anna-Maija Häkkinen; Hannele Yki-Järvinen
Topics:
1-phosphatidylinositol 3-kinase
,
insulin
,
lipids
,
skeletal muscles
,
tyrosine
Diabetes October 2001, Vol.50, 2337-2343. doi:https://doi.org/10.2337/diabetes.50.10.2337
Increased Lactate Release per Fat Cell in Normoglycemic First-Degree Relatives of Individuals With Type 2 Diabetes
Topics:
adipocytes
,
diabetes mellitus, type 2
,
lactates
,
microdialysis
,
insulin
Diabetes October 2001, Vol.50, 2344-2348. doi:https://doi.org/10.2337/diabetes.50.10.2344
Caffeine Ingestion Decreases Glucose Disposal During a Hyperinsulinemic-Euglycemic Clamp in Sedentary Humans
Topics:
caffeine
,
caffeine use
,
glucose
,
insulin
,
carbohydrates
Diabetes October 2001, Vol.50, 2349-2354. doi:https://doi.org/10.2337/diabetes.50.10.2349
Complications
Hexosamine-Induced Fibronectin Protein Synthesis in Mesangial Cells Is Associated With Increases in cAMP Responsive Element Binding (CREB) Phosphorylation and Nuclear CREB: The Involvement of Protein Kinases A and C
Topics:
cyclic amp-responsive dna-binding protein
,
fibronectins
,
hexosamines
,
phosphorylation
,
hypertension
Diabetes October 2001, Vol.50, 2355-2362. doi:https://doi.org/10.2337/diabetes.50.10.2355
Hyperglycemia Activates p53 and p53-Regulated Genes Leading to Myocyte Cell Death
Fabio Fiordaliso; Annarosa Leri; Daniela Cesselli; Federica Limana; Bijan Safai; Bernardo Nadal-Ginard; Piero Anversa; Jan Kajstura
Topics:
angiotensin ii
,
apoptosis
,
glucose
,
glycosylation
,
hyperglycemia
Diabetes October 2001, Vol.50, 2363-2375. doi:https://doi.org/10.2337/diabetes.50.10.2363
High Glucose–Enhanced Mesangial Cell Extracellular Signal–Regulated Protein Kinase Activation and α1(IV) Collagen Expression in Response to Endothelin-1: Role of Specific Protein Kinase C Isozymes
Topics:
cardiac support procedures
,
collagen
,
endothelin-1
,
isoenzymes
,
mast-cell sarcoma
Diabetes October 2001, Vol.50, 2376-2383. doi:https://doi.org/10.2337/diabetes.50.10.2376
Epidemiology
The Relation of Markers of Inflammation to the Development of Glucose Disorders in the Elderly: The Cardiovascular Health Study
Joshua I. Barzilay; Linn Abraham; Susan R. Heckbert; Mary Cushman; Lewis H. Kuller; Helaine E. Resnick; Russell P. Tracy
Topics:
cardiovascular health study
,
c-reactive protein
,
follow-up
,
glucose
,
impaired fasting glucose
Diabetes October 2001, Vol.50, 2384-2389. doi:https://doi.org/10.2337/diabetes.50.10.2384
A Prospective Study of Drinking Patterns in Relation to Risk of Type 2 Diabetes Among Men
Katherine M. Conigrave; B. Frank Hu; Carlos A. Camargo, Jr.,; Meir J. Stampfer; Walter C. Willett; Eric B. Rimm
Topics:
alcohol drinking
,
diabetes mellitus, type 2
,
ethanol
Diabetes October 2001, Vol.50, 2390-2395. doi:https://doi.org/10.2337/diabetes.50.10.2390
Genetics
A Major Gene Effect on Fasting Insulin and Insulin Sensitivity in Familial Combined Hyperlipidemia
Topics:
fasting
,
hyperlipidemia, familial combined
,
insulin
,
insulin sensitivity
,
overnight fasting insulin measurement
Diabetes October 2001, Vol.50, 2396-2401. doi:https://doi.org/10.2337/diabetes.50.10.2396
Brief Genetics Report
Characterization of the Annexin I Gene and Evaluation of Its Role in Type 2 Diabetes
Topics:
annexin a1
,
diabetes mellitus, type 2
,
genes
,
genotype determination
,
introns
Diabetes October 2001, Vol.50, 2402-2405. doi:https://doi.org/10.2337/diabetes.50.10.2402
Analysis of the Coding and Promoter Regions of the Autoantigen IA-2 in Subjects With and Without Autoantibodies to IA-2
Topics:
autoantibodies
,
autoantigens
,
promoter regions (genetics)
,
dna
,
nucleotides
Diabetes October 2001, Vol.50, 2406-2409. doi:https://doi.org/10.2337/diabetes.50.10.2406
A Common Hormone-Sensitive Lipase i6 Gene Polymorphism Is Associated With Decreased Human Adipocyte Lipolytic Function
Johan Hoffstedt; Peter Arner; Martin Schalling; Nancy L. Pedersen; Selim Sengul; Susanne Ahlberg; Anastasia Iliadou; Catharina Lavebratt
Topics:
adipocytes
,
alleles
,
forskolin
,
genes
,
lipolysis
Diabetes October 2001, Vol.50, 2410-2413. doi:https://doi.org/10.2337/diabetes.50.10.2410
Erratum
Erratum
Topics:
adoptive transfer
,
monoclonal antibodies
,
poly i-c
,
rats
,
thymocytes
Diabetes October 2001, Vol.50, 2414-2415. doi:https://doi.org/10.2337/diabetes.50.10.2414
