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Issues
Perspectives in Diabetes
Rapid Publication
Ghrelin, an Endogenous Growth Hormone Secretagogue, Is a Novel Orexigenic Peptide That Antagonizes Leptin Action Through the Activation of Hypothalamic Neuropeptide Y/Y1 Receptor Pathway
Mitsuyo Shintani; Yoshihiro Ogawa; Ken Ebihara; Megumi Aizawa-Abe; Fumiko Miyanaga; Kazuhiko Takaya; Tatsuya Hayashi; Gen Inoue; Kiminori Hosoda; Masayasu Kojima; Kenji Kangawa; Kazuwa Nakao
Diabetes February 2001, Vol.50, 227-232. doi:https://doi.org/10.2337/diabetes.50.2.227
Metabolism and Signal Transduction
Overexpression of 1-Acyl-Glycerol-3-Phosphate Acyltransferase-αEnhances Lipid Storage in Cellular Models of Adipose Tissue and Skeletal Muscle
Diabetes February 2001, Vol.50, 233-240. doi:https://doi.org/10.2337/diabetes.50.2.233
Nitric Oxide Increases Glucose Uptake Through a Mechanism That Is Distinct From the Insulin and Contraction Pathways in Rat Skeletal Muscle
Diabetes February 2001, Vol.50, 241-247. doi:https://doi.org/10.2337/diabetes.50.2.241
Effects of Chronic Central Nervous System Administration of Agouti-Related Protein in Pair-Fed Animals
Caroline J. Small; Min S. Kim; Sarah A. Stanley; John R.D. Mitchell; Kevin Murphy; David G.A. Morgan; Mohammad A. Ghatei; Stephen R. Bloom
Diabetes February 2001, Vol.50, 248-254. doi:https://doi.org/10.2337/diabetes.50.2.248
PKCδ Activation: A Divergence Point in the Signaling of Insulin and IGF-1—Induced Proliferation of Skin Keratinocytes
Shlomzion Shen; Addy Alt; Efrat Wertheimer; Marina Gartsbein; Toshio Kuroki; Motoi Ohba; Liora Braiman; Sanford R. Sampson; Tamar Tennenbaum
Diabetes February 2001, Vol.50, 255-264. doi:https://doi.org/10.2337/diabetes.50.2.255
Regulation of Glycogen Synthase Kinase-3 in Human Skeletal Muscle: Effects of Food Intake and Bicycle Exercise
Diabetes February 2001, Vol.50, 265-269. doi:https://doi.org/10.2337/diabetes.50.2.265
Immunology and Transplantation
Prolonged Islet Graft Survival in NOD Mice by Blockade of the CD40-CD154 Pathway of T-Cell Costimulation
R. Damaris Molano; Thierry Berney; Hua Li; Pierre Cattan; Antonello Pileggi; Caterina Vizzardelli; Norma S. Kenyon; Camillo Ricordi; Linda C. Burkly; Luca Inverardi
Diabetes February 2001, Vol.50, 270-276. doi:https://doi.org/10.2337/diabetes.50.2.270
Metabolic Effects of Restoring Partial β-Cell Function After Islet Allotransplantation in Type 1 Diabetic Patients
Livio Luzi; Gianluca Perseghin; Mathias D. Brendel; Ileana Terruzzi; Alberto Battezzati; Michael Eckhard; Daniel Brandhorst; Heide Brandhorst; Schirin Friemann; Carlo Socci; Valerio Di Carlo; Lucia Piceni Sereni; Stefano Benedini; Antonio Secchi; Guido Pozza; Reinhard G. Bretzel
Diabetes February 2001, Vol.50, 277-282. doi:https://doi.org/10.2337/diabetes.50.2.277
Islet Studies
Effects of Glucose and Amino Acids on Free ADP in βHC9 Insulin-Secreting Cells
Diabetes February 2001, Vol.50, 291-300. doi:https://doi.org/10.2337/diabetes.50.2.291
Defective Stimulus-Secretion Coupling in Islets of Psammomys obesus, an Animal Model for Type 2 Diabetes
Diabetes February 2001, Vol.50, 308-314. doi:https://doi.org/10.2337/diabetes.50.2.308
Lipotoxicity of the Pancreatic β-Cell Is Associated With Glucose-Dependent Esterification of Fatty Acids Into Neutral Lipids
Diabetes February 2001, Vol.50, 315-321. doi:https://doi.org/10.2337/diabetes.50.2.315
Dysregulation of Insulin Secretion in Children With Congenital Hyperinsulinism due to Sulfonylurea Receptor Mutations
A. Grimberg; R.J. Ferry, Jr.; A. Kelly; S. Koo-McCoy; K. Polonsky; B. Glaser; M.A. Permutt; L. Aguilar-Bryan; D. Stafford; P.S. Thornton; L. Baker; Charles A. Stanley
Diabetes February 2001, Vol.50, 322-328. doi:https://doi.org/10.2337/diabetes.50.2.322
Hyperinsulinism of Infancy: The Regulated Release of Insulin by KATP Channel—Independent Pathways
Susanne G. Straub; Karen E. Cosgrove; Carina Ämmälä; Ruth M. Shepherd; Rachel E. O'Brien; Philippa D. Barnes; Na'ama Kuchinski; Joanna C. Chapman; Michela Schaeppi; Benjamin Glaser; Keith J. Lindley; Geoffrey W.G. Sharp; Albert Aynsley-Green; Mark J. Dunne
Diabetes February 2001, Vol.50, 329-339. doi:https://doi.org/10.2337/diabetes.50.2.329
Characterization of a KATP Channel—Independent Pathway Involved in Potentiation of Insulin Secretion by Efaroxan
Diabetes February 2001, Vol.50, 340-347. doi:https://doi.org/10.2337/diabetes.50.2.340
Physiological Increase in Plasma Leptin Markedly Inhibits Insulin Secretion In Vivo
Jane A. Cases; Ilan Gabriely; Xiao Hui Ma; Xiao Man Yang; Tamar Michaeli; Norman Fleischer; Luciano Rossetti; Nir Barzilai
Diabetes February 2001, Vol.50, 348-352. doi:https://doi.org/10.2337/diabetes.50.2.348
Metabolic Regulation by Leucine of Translation Initiation Through the mTOR-Signaling Pathway by Pancreatic β-Cells
Diabetes February 2001, Vol.50, 353-360. doi:https://doi.org/10.2337/diabetes.50.2.353
Expression and Distribution of Lactate/Monocarboxylate Transporter Isoforms in Pancreatic Islets and the Exocrine Pancreas
Diabetes February 2001, Vol.50, 361-366. doi:https://doi.org/10.2337/diabetes.50.2.361
Pathophysiology
α- and β-Cell Responses to Small Changes in Plasma Glucose in the Conscious Dog
Diabetes February 2001, Vol.50, 367-375. doi:https://doi.org/10.2337/diabetes.50.2.367
Central Infusion of Histamine Reduces Fat Accumulation and Upregulates UCP Family in Leptin-Resistant Obese Mice
Diabetes February 2001, Vol.50, 376-384. doi:https://doi.org/10.2337/diabetes.50.2.376
Targeted Disruption of Histamine H1-Receptor Attenuates Regulatory Effects of Leptin on Feeding, Adiposity, and UCP Family in Mice
Diabetes February 2001, Vol.50, 385-391. doi:https://doi.org/10.2337/diabetes.50.2.385
Effects of Short-Term Improvement of Insulin Treatment and Glycemia on Hepatic Glycogen Metabolism in Type 1 Diabetes
Martin G. Bischof; Martin Krssak; Michael Krebs; Elisabeth Bernroider; Harald Stingl; Werner Waldhäusl; Michael Roden
Diabetes February 2001, Vol.50, 392-398. doi:https://doi.org/10.2337/diabetes.50.2.392
Hypoglycemic Detection Does Not Occur in the Hepatic Artery or Liver: Findings Consistent With a Portal Vein Glucosensor Locus
Diabetes February 2001, Vol.50, 399-403. doi:https://doi.org/10.2337/diabetes.50.2.399
Protection Against Oxidative Stress—Induced Insulin Resistance in Rat L6 Muscle Cells by Micromolar Concentrations of α-Lipoic Acid
Betty A. Maddux; Wendy See; John C. Lawrence, Jr.; Amy L. Goldfine; Ira D. Goldfine; Joseph L. Evans
Diabetes February 2001, Vol.50, 404-410. doi:https://doi.org/10.2337/diabetes.50.2.404
Peroxisome Proliferator—Activated Receptor (PPAR)-αActivation Lowers Muscle Lipids and Improves Insulin Sensitivity in High Fat—Fed Rats: Comparison With PPAR-γ Activation
Ji-Ming Ye; Patrick J. Doyle; Miguel A. Iglesias; David G. Watson; Gregory J. Cooney; Edward W. Kraegen
Diabetes February 2001, Vol.50, 411-417. doi:https://doi.org/10.2337/diabetes.50.2.411
Free Fatty Acids Induce Peripheral Insulin Resistance Without Increasing Muscle Hexosamine Pathway Product Levels in Rats
Diabetes February 2001, Vol.50, 418-424. doi:https://doi.org/10.2337/diabetes.50.2.418
Complications
Cyclic Stretch and Hypertension Induce Retinal Expression of Vascular Endothelial Growth Factor and Vascular Endothelial Growth Factor Receptor—2: Potential Mechanisms for Exacerbation of Diabetic Retinopathy by Hypertension
Izumi Suzuma; Yasuaki Hata; Allen Clermont; Frank Pokras; Susan L. Rook; Kiyoshi Suzuma; Edward P. Feener; Lloyd Paul Aiello
Diabetes February 2001, Vol.50, 444-454. doi:https://doi.org/10.2337/diabetes.50.2.444
The Effect of Diabetes on Expression of β1-,β2-, and β3-Adrenoreceptors in Rat Hearts
Ü. Deniz Dinçer; Keshore R. Bidasee; Şahika Güner; Ayin Tay; A. Tanju Özçelikay; V. Melih Altan
Diabetes February 2001, Vol.50, 455-461. doi:https://doi.org/10.2337/diabetes.50.2.455
Acute Hyperinsulinism Modulates Plasma Apolipoprotein B-48 Triglyceride—Rich Lipoproteins in Healthy Subjects During the Postprandial Period
Amandine Harbis; Catherine Defoort; Hervé Narbonne; Christine Juhel; Michèle Senft; Christian Latgé; Blandine Delenne; Henri Portugal; Catherine Atlan-Gepner; Bernard Vialettes; Denis Lairon
Diabetes February 2001, Vol.50, 462-469. doi:https://doi.org/10.2337/diabetes.50.2.462
