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Volume 50, Issue 4
1 April 2001
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ISSN 0012-1797
EISSN 1939-327X
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Rapid Publication

Circulating Ghrelin Levels Are Decreased in Human Obesity
Matthias Tschöp; Christian Weyer; P. Antonio Tataranni; Viswanath Devanarayan; Eric Ravussin; Mark L. Heiman
View articletitled, Circulating Ghrelin Levels Are Decreased in Human Obesity
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Diabetes April 2001, Vol.50, 707-709. doi:https://doi.org/10.2337/diabetes.50.4.707
Clinical Outcomes and Insulin Secretion After Islet Transplantation With the Edmonton Protocol
Edmond A. Ryan; Jonathan R.T. Lakey; Ray V. Rajotte; Gregory S. Korbutt; Tatsuya Kin; Sharleen Imes; Alex Rabinovitch; John F. Elliott; David Bigam; Norman M. Kneteman; Garth L. Warnock; Ingrid Larsen; A.M. James Shapiro
View articletitled, Clinical Outcomes and Insulin Secretion After Islet Transplantation With the Edmonton Protocol
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Diabetes April 2001, Vol.50, 710-719. doi:https://doi.org/10.2337/diabetes.50.4.710

Metabolism and Signal Transduction

Control of Glycogen Synthesis by Glucose, Glycogen, and Insulin in Cultured Human Muscle Cells
Reza Halse; Sylvie M. Bonavaud; Jane L. Armstrong; James G. McCormack; Stephen J. Yeaman
View articletitled, Control of Glycogen Synthesis by Glucose, Glycogen, and Insulin in Cultured Human Muscle Cells
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Diabetes April 2001, Vol.50, 720-726. doi:https://doi.org/10.2337/diabetes.50.4.720
In Normal Men, Free Fatty Acids Reduce Peripheral but Not Splanchnic Glucose Uptake
Vincent Rigalleau; Christophe Binnert; Kaori Minehira; Nathalie Stefanoni; Phillippe Schneiter; Emmanuel Henchoz; Oscar Matzinger; Christine Cayeux; Eric Jéquier; Luc Tappy
View articletitled, In Normal Men, Free Fatty Acids Reduce Peripheral but Not Splanchnic Glucose Uptake
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Diabetes April 2001, Vol.50, 727-732. doi:https://doi.org/10.2337/diabetes.50.4.727
Cerulenin Mimics Effects of Leptin on Metabolic Rate, Food Intake, and Body Weight Independent of the Melanocortin System, but Unlike Leptin, Cerulenin Fails to Block Neuroendocrine Effects of Fasting
Hideo Makimura; Tooru M. Mizuno; Xue-Jun Yang; Jeff Silverstein; Joe Beasley; Charles V. Mobbs
View articletitled, Cerulenin Mimics Effects of Leptin on Metabolic Rate, Food Intake, and Body Weight Independent of the Melanocortin System, but Unlike Leptin, Cerulenin Fails to Block Neuroendocrine Effects of Fasting
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Diabetes April 2001, Vol.50, 733-739. doi:https://doi.org/10.2337/diabetes.50.4.733
Rat Small Intestine Is an Insulin-Sensitive Gluconeogenic Organ
Martine Croset; Fabienne Rajas; Carine Zitoun; Jean-Marc Hurot; Sandrine Montano; Gilles Mithieux
View articletitled, Rat Small Intestine Is an Insulin-Sensitive Gluconeogenic Organ
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Diabetes April 2001, Vol.50, 740-746. doi:https://doi.org/10.2337/diabetes.50.4.740
Assessment of Postabsorptive Renal Glucose Metabolism in Humans With Multiple Glucose Tracers
Niels Moller; Robert A. Rizza; G. Charles Ford; K. Sreekumaran Nair
View articletitled, Assessment of Postabsorptive Renal Glucose Metabolism in Humans With Multiple Glucose Tracers
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Diabetes April 2001, Vol.50, 747-751. doi:https://doi.org/10.2337/diabetes.50.4.747

Immunology and Transplantation

Autoantibody Response to CD38 in Caucasian Patients With Type 1 and Type 2 Diabetes: Immunological and Genetic Characterization
Roberto Mallone; Erika Ortolan; Germano Baj; Ada Funaro; Sara Giunti; Emma Lillaz; Franca Saccucci; Maurizio Cassader; Paolo Cavallo-Perin; Fabio Malavasi
View articletitled, Autoantibody Response to CD38 in Caucasian Patients With Type 1 and Type 2 Diabetes<span class="subtitle-colon">: </span><span class="subtitle">Immunological and Genetic Characterization</span>
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Diabetes April 2001, Vol.50, 752-762. doi:https://doi.org/10.2337/diabetes.50.4.752
Development and Function of Diabetogenic T-cells in B-cell–Deficient Nonobese Diabetic Mice
Priscilla P.L. Chiu; David V. Serreze; Jayne S. Danska
View articletitled, Development and Function of Diabetogenic T-cells in B-cell–Deficient Nonobese Diabetic Mice
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Diabetes April 2001, Vol.50, 763-770. doi:https://doi.org/10.2337/diabetes.50.4.763
Mucosal Antigen Primes Diabetogenic Cytotoxic T-Lymphocytes Regardless of Dose or Delivery Route
Arno Hänninen; Andrea Braakhuis; William R. Heath; Leonard C. Harrison
View articletitled, Mucosal Antigen Primes Diabetogenic Cytotoxic T-Lymphocytes Regardless of Dose or Delivery Route
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Diabetes April 2001, Vol.50, 771-775. doi:https://doi.org/10.2337/diabetes.50.4.771

Islet Studies

Glucagon-Like Peptide 1 Increases Secretory Burst Mass of Pulsatile Insulin Secretion in Patients With Type 2 Diabetes and Impaired Glucose Tolerance
Robert Ritzel; Miriam Schulte; Niels Pørksen; Markus S. Nauck; Jens J. Holst; Claus Juhl; Winfried März; Ole Schmitz; Wolff H. Schmiegel; Michael A. Nauck
View articletitled, Glucagon-Like Peptide 1 Increases Secretory Burst Mass of Pulsatile Insulin Secretion in Patients With Type 2 Diabetes and Impaired Glucose Tolerance
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Diabetes April 2001, Vol.50, 776-784. doi:https://doi.org/10.2337/diabetes.50.4.776
Glucagon-Like Peptide 1 Induces Differentiation of Islet Duodenal Homeobox-1–Positive Pancreatic Ductal Cells Into Insulin-Secreting Cells
Hongxiang Hui; Chris Wright; Riccardo Perfetti
View articletitled, Glucagon-Like Peptide 1 Induces Differentiation of Islet Duodenal Homeobox-1–Positive Pancreatic Ductal Cells Into Insulin-Secreting Cells
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Diabetes April 2001, Vol.50, 785-796. doi:https://doi.org/10.2337/diabetes.50.4.785
The Novel Imidazoline Compound BL11282 Potentiates Glucose-Induced Insulin Secretion in Pancreatic β-Cells in the Absence of Modulation of KATP Channel Activity
Alexander M. Efanov; Sergei V. Zaitsev; Hans-Juergen Mest; Achim Raap; Ioulia B. Appelskog; Olof Larsson; Per-Olof Berggren; Suad Efendic
View articletitled, The Novel Imidazoline Compound BL11282 Potentiates Glucose-Induced Insulin Secretion in Pancreatic β-Cells in the Absence of Modulation of K<sub>ATP</sub> Channel Activity
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Diabetes April 2001, Vol.50, 797-802. doi:https://doi.org/10.2337/diabetes.50.4.797
Uncoupling Protein 2: A Possible Link Between Fatty Acid Excess and Impaired Glucose-Induced Insulin Secretion?
Nathalie Lameloise; Patrick Muzzin; Marc Prentki; Françoise Assimacopoulos-Jeannet
View articletitled, Uncoupling Protein 2: A Possible Link Between Fatty Acid Excess and Impaired Glucose-Induced Insulin Secretion?
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Diabetes April 2001, Vol.50, 803-809. doi:https://doi.org/10.2337/diabetes.50.4.803

Pathophysiology

Effects of Free Fatty Acids on Gluconeogenesis and Autoregulation of Glucose Production in Type 2 Diabetes
Guenther Boden; Xinhua Chen; Edwin Capulong; Maria Mozzoli
View articletitled, Effects of Free Fatty Acids on Gluconeogenesis and Autoregulation of Glucose Production in Type 2 Diabetes
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Diabetes April 2001, Vol.50, 810-816. doi:https://doi.org/10.2337/diabetes.50.4.810
Skeletal Muscle Lipid Content and Oxidative Enzyme Activity in Relation to Muscle Fiber Type in Type 2 Diabetes and Obesity
Jing He; Simon Watkins; David E. Kelley
View articletitled, Skeletal Muscle Lipid Content and Oxidative Enzyme Activity in Relation to Muscle Fiber Type in Type 2 Diabetes and Obesity
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Diabetes April 2001, Vol.50, 817-823. doi:https://doi.org/10.2337/diabetes.50.4.817
A Novel Small Molecule That Directly Sensitizes the Insulin Receptor In Vitro and In Vivo
Vara Prasad Manchem; Ira D. Goldfine; Ronald A. Kohanski; Cristina P. Cristobal; Robert T. Lum; Steven R. Schow; Songyuan Shi; Wayne R. Spevak; Edgardo Laborde; Deborah K. Toavs; Hugo O. Villar; Michael M. Wick; Michael R. Kozlowski
View articletitled, A Novel Small Molecule That Directly Sensitizes the Insulin Receptor In Vitro and In Vivo
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Diabetes April 2001, Vol.50, 824-830. doi:https://doi.org/10.2337/diabetes.50.4.824
The Q Allele Variant (GLN121) of Membrane Glycoprotein PC-1 Interacts With the Insulin Receptor and Inhibits Insulin Signaling More Effectively Than the Common K Allele Variant (LYS121)
Benedetta V. Costanzo; Vincenzo Trischitta; Rosa Di Paola; Daniela Spampinato; Antonio Pizzuti; Riccardo Vigneri; Lucia Frittitta
View articletitled, The Q Allele Variant (GLN<sup>121</sup>) of Membrane Glycoprotein PC-1 Interacts With the Insulin Receptor and Inhibits Insulin Signaling More Effectively Than the Common K Allele Variant (LYS<sup>121</sup>)
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Diabetes April 2001, Vol.50, 831-836. doi:https://doi.org/10.2337/diabetes.50.4.831

Complications

Increased QTc Dispersion Is Related to Blunted Circadian Blood Pressure Variation in Normoalbuminuric Type 1 Diabetic Patients
Per Løgstrup Poulsen; Eva Ebbehøj; Hanne Arildsen; Søren Tang Knudsen; Klaus Würgler Hansen; Henning Mølgaard; Carl Erik Mogensen
View articletitled, Increased QTc Dispersion Is Related to Blunted Circadian Blood Pressure Variation in Normoalbuminuric Type 1 Diabetic Patients
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Diabetes April 2001, Vol.50, 837-842. doi:https://doi.org/10.2337/diabetes.50.4.837
Effect of 3 Years of Antihypertensive Therapy on Renal Structure in Type 1 Diabetic Patients With Albuminuria: The European Study for the Prevention of Renal Disease in Type 1 Diabetes (ESPRIT)
The European Study for the Prevention of Renal Disease in Type 1 Diabetes ESPRIT Study Group
View articletitled, Effect of 3 Years of Antihypertensive Therapy on Renal Structure in Type 1 Diabetic Patients With Albuminuria<span class="subtitle-colon">: </span><span class="subtitle">The European Study for the Prevention of Renal Disease in Type 1 Diabetes (ESPRIT)</span>
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Diabetes April 2001, Vol.50, 843-850. doi:https://doi.org/10.2337/diabetes.50.4.843
Diabetes Accelerates Smooth Muscle Accumulation in Lesions of Atherosclerosis: Lack of Direct Growth-Promoting Effects of High Glucose Levels
Lucy A. Suzuki; Martin Poot; Ross G. Gerrity; Karin E. Bornfeldt
View articletitled, Diabetes Accelerates Smooth Muscle Accumulation in Lesions of Atherosclerosis<span class="subtitle-colon">: </span><span class="subtitle">Lack of Direct Growth-Promoting Effects of High Glucose Levels</span>
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Diabetes April 2001, Vol.50, 851-860. doi:https://doi.org/10.2337/diabetes.50.4.851
Familial Aggregation of Coronary Artery Calcium in Families With Type 2 Diabetes
Lynne E. Wagenknecht; Donald W. Bowden; J. Jeffrey Carr; Carl D. Langefeld; Barry I. Freedman; Stephen S. Rich
View articletitled, Familial Aggregation of Coronary Artery Calcium in Families With Type 2 Diabetes
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Diabetes April 2001, Vol.50, 861-866. doi:https://doi.org/10.2337/diabetes.50.4.861
Angiotensin II Induces Expression of the Tie2 Receptor Ligand, Angiopoietin-2, in Bovine Retinal Endothelial Cells
Atsushi Otani; Hitoshi Takagi; Hideyasu Oh; Shinji Koyama; Yoshihito Honda
View articletitled, Angiotensin II Induces Expression of the Tie2 Receptor Ligand, Angiopoietin-2, in Bovine Retinal Endothelial Cells
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Diabetes April 2001, Vol.50, 867-875. doi:https://doi.org/10.2337/diabetes.50.4.867

Genetics

Pro12Ala Polymorphism in the Peroxisome Proliferator–Activated Receptor-γ2 Gene Is Associated With Increased Antilipolytic Insulin Sensitivity
Michael Stumvoll; Hans Günther Wahl; Klaus Löblein; Regine Becker; Fausto Machicao; Stephan Jacob; Hans Häring
View articletitled, Pro12Ala Polymorphism in the Peroxisome Proliferator–Activated Receptor-γ<sub>2</sub> Gene Is Associated With Increased Antilipolytic Insulin Sensitivity
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Diabetes April 2001, Vol.50, 876-881. doi:https://doi.org/10.2337/diabetes.50.4.876

Brief Genetics Report

The Gly972Arg Polymorphism in the Insulin Receptor Substrate-1 Gene Contributes to the Variation in insulin Secretion in Normal Glucose-Tolerant Humans
Michael Stumvoll; Andreas Fritsche; Annette Volk; Norbert Stefan; Alexander Madaus; Elke Maerker; Anna Teigeler; Matthias Koch; Fausto Machicao; Hans Häring
View articletitled, The Gly972Arg Polymorphism in the Insulin Receptor Substrate-1 Gene Contributes to the Variation in insulin Secretion in Normal Glucose-Tolerant Humans
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Diabetes April 2001, Vol.50, 882-885. doi:https://doi.org/10.2337/diabetes.50.4.882
The Peroxisome Poliferator–Activated Receptor-γ2 Pro12Ala Variant: Association With Type 2 Diabetes and Trait Differences
Julie A. Douglas; Michael R. Erdos; Richard M. Watanabe; Andi Braun; Cristy L. Johnston; Paul Oeth; Karen L. Mohlke; Timo T. Valle; Christian Ehnholm; Thomas A. Buchanan; Richard N. Bergman; Francis S. Collins; Michael Boehnke; Jaakko Tuomilehto
View articletitled, The Peroxisome Poliferator–Activated Receptor-γ2 Pro12Ala Variant<span class="subtitle-colon">: </span><span class="subtitle">Association With Type 2 Diabetes and Trait Differences</span>
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Diabetes April 2001, Vol.50, 886-890. doi:https://doi.org/10.2337/diabetes.50.4.886
The Pro12→Ala Substitution in PPAR-γ Is Associated With Resistance to Development of Diabetes in the General Population: Possible Involvement in Impairment of Insulin Secretion in Individuals With Type 2 Diabetes
Hiroyuki Mori; Hiroshi Ikegami; Yoshihiko Kawaguchi; Susumu Seino; Norihide Yokoi; Jun Takeda; Ituro Inoue; Yutaka Seino; Koichiro Yasuda; Toshiaki Hanafusa; Kazuya Yamagata; Takuya Awata; Takashi Kadowaki; Kazuo Hara; Nobuhiro Yamada; Takanari Gotoda; Naoko Iwasaki; Yasuhiko Iwamoto; Tokio Sanke; Kishio Nanjo; Yoshitomo Oka; Akira Matsutani; Eiichi Maeda; Masato Kasuga
View articletitled, The Pro<sup>12</sup>→Ala Substitution in PPAR-γ Is Associated With Resistance to Development of Diabetes in the General Population<span class="subtitle-colon">: </span><span class="subtitle">Possible Involvement in Impairment of Insulin Secretion in Individuals With Type 2 Diabetes</span>
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Diabetes April 2001, Vol.50, 891-894. doi:https://doi.org/10.2337/diabetes.50.4.891
Differential Splicing of the IA-2 mRNA in Pancreas and Lymphoid Organs as a Permissive Genetic Mechanism for Autoimmunity Against the IA-2 Type 1 Diabetes Autoantigen
Juan Diez; Yongsoo Park; Markus Zeller; Douglas Brown; David Garza; Camillo Ricordi; John Hutton; George S. Eisenbarth; Alberto Pugliese
View articletitled, Differential Splicing of the IA-2 mRNA in Pancreas and Lymphoid Organs as a Permissive Genetic Mechanism for Autoimmunity Against the IA-2 Type 1 Diabetes Autoantigen
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Diabetes April 2001, Vol.50, 895-900. doi:https://doi.org/10.2337/diabetes.50.4.895
A Ser311Cys Mutation in the Human Dopamine Receptor D2 Gene Is Associated With Reduced Energy Expenditure
P. Antonio Tataranni; Leslie Baier; Chris Jenkinson; Inge Harper; Angelo Del Parigi; Clifton Bogardus
View articletitled, A Ser311Cys Mutation in the Human Dopamine Receptor D2 Gene Is Associated With Reduced Energy Expenditure
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Diabetes April 2001, Vol.50, 901-904. doi:https://doi.org/10.2337/diabetes.50.4.901

Letter to the Editor

Measurements of Renal Glucose Release
John E. Gerich, MD
View articletitled, Measurements of Renal Glucose Release
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Diabetes April 2001, Vol.50, 905. doi:https://doi.org/10.2337/diabetes.50.4.905
MRI Metrics of Cerebral Endothelial Cell–Derived Exosomes for the Treatment of Cognitive Dysfunction Induced in Aging Rats Subjected to Type 2 Diabetes
Management of Latent Autoimmune Diabetes in Adults: A Consensus Statement From an International Expert Panel
713-P: Is There a Correct Time to Measure Fasting Blood Sugar in Persons with Type 2 Diabetes Melitus?
Elevated First-Trimester Neutrophil Count Is Closely Associated With the Development of Maternal Gestational Diabetes Mellitus and Adverse Pregnancy Outcomes
300-OR: Beneficial Effect of the Combination Therapy of Cagrilintide, a Dual Amylin/Calcitonin Agonist, and Tirzepatide, a Dual GLP-1/GIP Agonist, on Body Weight Loss in Obese Rats
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