Skip Nav Destination
Issues
1 June 2001
ISSN 0012-1797
EISSN 1939-327X
Rapid Publication
Successful Reversal of Streptozotocin-Induced Diabetes With Stable Allogeneic Islet Function in a Preclinical Model of Type 1 Diabetes
Judith M. Thomas; Juan L. Contreras; Cheryl A. Smyth; Andrew Lobashevsky; Stacie Jenkins; William J. Hubbard; Devin E. Eckhoff; Scott Stavrou; David M. Neville Jr.; Francis T. Thomas
Diabetes June 2001, Vol.50, 1227-1236. doi:https://doi.org/10.2337/diabetes.50.6.1227
Metabolism and Signal Transduction
A Daily Rhythm in Glucose Tolerance: A Role for the Suprachiasmatic Nucleus
Diabetes June 2001, Vol.50, 1237-1243. doi:https://doi.org/10.2337/diabetes.50.6.1237
Protein Kinase C (PKC)-α Activation Inhibits PKC-ζ and Mediates the Action of PED/PEA-15 on Glucose Transport in the L6 Skeletal Muscle Cells
Gerolama Condorelli; Giovanni Vigliotta; Alessandra Trencia; Maria Alessandra Maitan; Matilde Caruso; Claudia Miele; Francesco Oriente; Stefania Santopietro; Pietro Formisano; Francesco Beguinot
Diabetes June 2001, Vol.50, 1244-1252. doi:https://doi.org/10.2337/diabetes.50.6.1244
Stimulating Effects of Low-Dose Fructose on Insulin-Stimulated Hepatic Glycogen Synthesis in Humans
Diabetes June 2001, Vol.50, 1263-1268. doi:https://doi.org/10.2337/diabetes.50.6.1263
Immunology and Transplantation
Pancreatic Biopsy as a Procedure for Detecting In Situ Autoimmune Phenomena in Type 1 Diabetes: Close Correlation Between Serological Markers and Histological Evidence of Cellular Autoimmunity
Akihisa Imagawa; Toshiaki Hanafusa; Shinji Tamura; Makoto Moriwaki; Naoto Itoh; Koji Yamamoto; Hiromi Iwahashi; Kazuya Yamagata; Masako Waguri; Takao Nanmo; Sae Uno; Hiromu Nakajima; Mitsuyoshi Namba; Sumio Kawata; Jun-ichiro Miyagawa; Yuji Matsuzawa
Diabetes June 2001, Vol.50, 1269-1273. doi:https://doi.org/10.2337/diabetes.50.6.1269
Peptide and Major Histocompatibility Complex–Specific Breaking of Humoral Tolerance to Native Insulin With the B9-23 Peptide in Diabetes-Prone and Normal Mice
Norio Abiru; Aristides K. Maniatis; Liping Yu; Dongmei Miao; Hiroaki Moriyama; Dale Wegmann; George S. Eisenbarth
Diabetes June 2001, Vol.50, 1274-1281. doi:https://doi.org/10.2337/diabetes.50.6.1274
Islet Studies
Evidence That Extrapancreatic GLUT2-Dependent Glucose Sensors Control Glucagon Secretion
Diabetes June 2001, Vol.50, 1282-1289. doi:https://doi.org/10.2337/diabetes.50.6.1282
High Glucose Causes Apoptosis in Cultured Human Pancreatic Islets of Langerhans: A Potential Role for Regulation of Specific Bcl Family Genes Toward an Apoptotic Cell Death Program
Massimo Federici; Marta Hribal; Lucia Perego; Marco Ranalli; Zaira Caradonna; Carla Perego; Luciana Usellini; Rita Nano; Paolo Bonini; Federico Bertuzzi; Lionel N.J.L. Marlier; Alberto M. Davalli; Orazio Carandente; Antonio E. Pontiroli; Gerry Melino; Piero Marchetti; Renato Lauro; Giorgio Sesti; Franco Folli
Diabetes June 2001, Vol.50, 1290-1301. doi:https://doi.org/10.2337/diabetes.50.6.1290
Increased Uncoupling Protein-2 Levels in β-cells Are Associated With Impaired Glucose-Stimulated Insulin Secretion: Mechanism of Action
Catherine B. Chan; Domenica De Leo; Jamie W. Joseph; Timothy S. McQuaid; Xiao Fang Ha; Fang Xu; Robert G. Tsushima; Peter S. Pennefather; Anne Marie F. Salapatek; Michael B. Wheeler
Diabetes June 2001, Vol.50, 1302-1310. doi:https://doi.org/10.2337/diabetes.50.6.1302
A Neuronal Isoform of Nitric Oxide Synthase Expressed in Pancreatic β-Cells Controls Insulin Secretion
Anne-Dominique Lajoix; Hubbert Reggio; Thierry Chardès; Sylvie Péraldi-Roux; Florence Tribillac; Michèle Roye; Samuel Dietz; Christophe Broca; Michèle Manteghetti; Gérard Ribes; Claes B. Wollheim; René Gross
Diabetes June 2001, Vol.50, 1311-1323. doi:https://doi.org/10.2337/diabetes.50.6.1311
Pathophysiology
Ezetimibe, a Potent Cholesterol Absorption Inhibitor, Normalizes Combined Dyslipidemia in Obese Hyperinsulinemic Hamsters
Margaret van Heek; Theodore M. Austin; Constance Farley; John A. Cook; Glen G. Tetzloff; Harry R. Davis
Diabetes June 2001, Vol.50, 1330-1335. doi:https://doi.org/10.2337/diabetes.50.6.1330
Protein Metabolism in Clinically Stable Adult Cystic Fibrosis Patients With Abnormal Glucose Tolerance
Diabetes June 2001, Vol.50, 1336-1343. doi:https://doi.org/10.2337/diabetes.50.6.1336
Type 2 Diabetes Impairs Splanchnic Uptake of Glucose but Does Not Alter Intestinal Glucose Absorption During Enteral Glucose Feeding: Additional Evidence for a Defect in Hepatic Glucokinase Activity
Ananda Basu; Rita Basu; Pankaj Shah; Adrian Vella; C. Michael Johnson; Michael Jensen; K. Sreekumaran Nair; W. Frederick Schwenk; Robert A. Rizza
Diabetes June 2001, Vol.50, 1351-1362. doi:https://doi.org/10.2337/diabetes.50.6.1351
Assessment of Hepatic Insulin Action in Obese Type 2 Diabetic Patients
Diabetes June 2001, Vol.50, 1363-1370. doi:https://doi.org/10.2337/diabetes.50.6.1363
Resistance to Exercise-Induced Increase in Glucose Uptake During Hyperinsulinemia in Insulin-Resistant Skeletal Muscle of Patients With Type 1 Diabetes
Pauliina Peltoniemi; Hannele Yki-Järvinen; Vesa Oikonen; Airi Oksanen; Teemu O. Takala; Tapani Rönnemaa; Matti Erkinjuntti; M. Juhani Knuuti; Pirjo Nuutila
Diabetes June 2001, Vol.50, 1371-1377. doi:https://doi.org/10.2337/diabetes.50.6.1371
The HIV Protease Inhibitor Indinavir Impairs Sterol Regulatory Element-Binding Protein-1 Intranuclear Localization, Inhibits Preadipocyte Differentiation, and Induces Insulin Resistance
Martine Caron; Martine Auclair; Corinne Vigouroux; Martine Glorian; Claude Forest; Jacqueline Capeau
Diabetes June 2001, Vol.50, 1378-1388. doi:https://doi.org/10.2337/diabetes.50.6.1378
Increased Fatty Acid Uptake and Altered Fatty Acid Metabolism in Insulin-Resistant Muscle of Obese Zucker Rats
Diabetes June 2001, Vol.50, 1389-1396. doi:https://doi.org/10.2337/diabetes.50.6.1389
The HIV Protease Inhibitor Indinavir Decreases Insulin- and Contraction-Stimulated Glucose Transport in Skeletal Muscle
Lorraine A. Nolte; Kevin E. Yarasheski; Kentaro Kawanaka; Jonathan Fisher; Ngan Le; John O. Holloszy
Diabetes June 2001, Vol.50, 1397-1401. doi:https://doi.org/10.2337/diabetes.50.6.1397
The Effect of Systemic Versus Portal Insulin Delivery in Pancreas Transplantation on Insulin Action and VLDL Metabolism
André Carpentier; Bruce W. Patterson; Kristine D. Uffelman; Adria Giacca; Mladen Vranic; Mark S. Cattral; Gary F. Lewis
Diabetes June 2001, Vol.50, 1402-1413. doi:https://doi.org/10.2337/diabetes.50.6.1402
IGF-1 Overexpression Inhibits the Development of Diabetic Cardiomyopathy and Angiotensin II–Mediated Oxidative Stress
Jan Kajstura; Fabio Fiordaliso; Anna Maria Andreoli; Baosheng Li; Stefano Chimenti; Marvin S. Medow; Federica Limana; Bernardo Nadal-Ginard; Annarosa Leri; Piero Anversa
Diabetes June 2001, Vol.50, 1414-1424. doi:https://doi.org/10.2337/diabetes.50.6.1414
The HIV Protease Inhibitor Nelfinavir Induces Insulin Resistance and Increases Basal Lipolysis in 3T3-L1 Adipocytes
Assaf Rudich; Sharon Vanounou; Klaris Riesenberg; Michal Porat; Amir Tirosh; Ilana Harman-Boehm; Andrew S. Greenberg; Francisc Schlaeffer; Nava Bashan
Diabetes June 2001, Vol.50, 1425-1431. doi:https://doi.org/10.2337/diabetes.50.6.1425
Increased Prevalence of Microthromboses in Retinal Capillaries of Diabetic Individuals
Diabetes June 2001, Vol.50, 1432-1439. doi:https://doi.org/10.2337/diabetes.50.6.1432
Transgenic Overexpression of Leptin Rescues Insulin Resistance and Diabetes in a Mouse Model of Lipoatrophic Diabetes
Ken Ebihara; Yoshihiro Ogawa; Hiroaki Masuzaki; Mitsuyo Shintani; Fumiko Miyanaga; Megumi Aizawa-Abe; Tatsuya Hayashi; Kiminori Hosoda; Gen Inoue; Yasunao Yoshimasa; Oksana Gavrilova; Marc L. Reitman; Kazuwa Nakao
Diabetes June 2001, Vol.50, 1440-1448. doi:https://doi.org/10.2337/diabetes.50.6.1440
Insulin Sensitivity of Suppression of Endogenous Glucose Production Is the Single Most Important Determinant of Glucose Tolerance
Diabetes June 2001, Vol.50, 1449-1454. doi:https://doi.org/10.2337/diabetes.50.6.1449
Subcellular Localization of Insulin Receptor Substrate Family Proteins Associated With Phosphatidylinositol 3-Kinase Activity and Alterations in Lipolysis in Primary Mouse Adipocytes From IRS-1 Null Mice
Youki Tsuji; Yasushi Kaburagi; Yasuo Terauchi; Shinobu Satoh; Naoto Kubota; Hiroyuki Tamemoto; Fredric B. Kraemer; Hisahiko Sekihara; Shinichi Aizawa; Yasuo Akanuma; Kazuyuki Tobe; Satoshi Kimura; Takashi Kadowaki
Diabetes June 2001, Vol.50, 1455-1463. doi:https://doi.org/10.2337/diabetes.50.6.1455
The Antihyperglycemic Drug α-Lipoic Acid Stimulates Glucose Uptake via Both GLUT4 Translocation and GLUT4 Activation: Potential Role of p38 Mitogen-Activated Protein Kinase in GLUT4 Activation
Daniel Konrad; Romel Somwar; Gary Sweeney; Karen Yaworsky; Michiko Hayashi; Toolsie Ramlal; Amira Klip
Diabetes June 2001, Vol.50, 1464-1471. doi:https://doi.org/10.2337/diabetes.50.6.1464
Complications
Phosphorylation of p38 Mitogen-Activated Protein Kinase Downstream of Bax-Caspase-3 Pathway Leads to Cell Death Induced by High d-Glucose in Human Endothelial Cells
Hironori Nakagami; Ryuichi Morishita; Kei Yamamoto; Shin-ichi Yoshimura; Yoshiaki Taniyama; Motokuni Aoki; Hiroaki Matsubara; Shokei Kim; Yasufumi Kaneda; Toshio Ogihara
Diabetes June 2001, Vol.50, 1472-1481. doi:https://doi.org/10.2337/diabetes.50.6.1472
Hypoxia Stimulates Osteopontin Expression and Proliferation of Cultured Vascular Smooth Muscle Cells: Potentiation by High Glucose
Diabetes June 2001, Vol.50, 1482-1490. doi:https://doi.org/10.2337/diabetes.50.6.1482
Hyperglycemia Potentiates Collagen-Induced Platelet Activation Through Mitochondrial Superoxide Overproduction
Diabetes June 2001, Vol.50, 1491-1494. doi:https://doi.org/10.2337/diabetes.50.6.1491
Requirement for p38 and p44/p42 Mitogen-Activated Protein Kinases in RAGE-Mediated Nuclear Factor-κB Transcriptional Activation and Cytokine Secretion
Chen-Hsiung Yeh; Lydia Sturgis; Joe Haidacher; Xue-Nong Zhang; Sidney J. Sherwood; Robert J. Bjercke; Ondrej Juhasz; Michael T. Crow; Ronald G. Tilton; Larry Denner
Diabetes June 2001, Vol.50, 1495-1504. doi:https://doi.org/10.2337/diabetes.50.6.1495
Effects of Novel Polymorphisms in the RAGE Gene on Transcriptional Regulation and Their Association With Diabetic Retinopathy
Diabetes June 2001, Vol.50, 1505-1511. doi:https://doi.org/10.2337/diabetes.50.6.1505
