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Issues
1 January 2002
ISSN 0012-1797
EISSN 1939-327X
Rapid Publication
A P387L Variant in Protein Tyrosine Phosphatase-1B (PTP-1B) Is Associated With Type 2 Diabetes and Impaired Serine Phosphorylation of PTP-1B In Vitro
Søren M. Echwald; Helle Bach; Henrik Vestergaard; Bjørn Richelsen; Kurt Kristensen; Thomas Drivsholm; Knut Borch-Johnsen; Torben Hansen; Oluf Pedersen
Diabetes January 2002, Vol.51, 1-6. doi:https://doi.org/10.2337/diabetes.51.1.1
Banting Lecture 2001
Banting Lecture 2001: Dysregulation of Fatty Acid Metabolism in the Etiology of Type 2 Diabetes
Diabetes January 2002, Vol.51, 7-18. doi:https://doi.org/10.2337/diabetes.51.1.7
Metabolism and Signal Transduction
Phosphatidylinositol 3-Kinase Redistribution Is Associated With Skeletal Muscle Insulin Resistance in Gestational Diabetes Mellitus
Diabetes January 2002, Vol.51, 19-29. doi:https://doi.org/10.2337/diabetes.51.1.19
Regulation of Glucose Transport and Insulin Signaling by Troglitazone or Metformin in Adipose Tissue of Type 2 Diabetic Subjects
Theodore P. Ciaraldi; Alice P.S. Kong; Neelima V. Chu; Dennis D. Kim; Sunita Baxi; Mattias Loviscach; Ray Plodkowski; Richard Reitz; Michael Caulfield; Sunder Mudaliar; Robert R. Henry
Diabetes January 2002, Vol.51, 30-36. doi:https://doi.org/10.2337/diabetes.51.1.30
Association of the T-G Polymorphism in Adiponectin (Exon 2) With Obesity and Insulin Sensitivity: Interaction With Family History of Type 2 Diabetes
Michael Stumvoll; Otto Tschritter; Andreas Fritsche; Harald Staiger; Walter Renn; Melanie Weisser; Fausto Machicao; Hans Häring
Diabetes January 2002, Vol.51, 37-41. doi:https://doi.org/10.2337/diabetes.51.1.37
Skeletal Muscle Microvascular Recruitment by Physiological Hyperinsulinemia Precedes Increases in Total Blood Flow
Diabetes January 2002, Vol.51, 42-48. doi:https://doi.org/10.2337/diabetes.51.1.42
Hepatic Glycogen Metabolism in Type 1 Diabetes After Long-Term Near Normoglycemia
Martin G. Bischof; Elisabeth Bernroider; Martin Krssak; Michael Krebs; Harald Stingl; Peter Nowotny; Chunlin Yu; Gerald I. Shulman; Werner Waldhäusl; Michael Roden
Diabetes January 2002, Vol.51, 49-54. doi:https://doi.org/10.2337/diabetes.51.1.49
Immunology and Transplantation
Human Pancreatic Islets Produce and Secrete MCP-1/CCL2: Relevance in Human Islet Transplantation
Lorenzo Piemonti; Biagio Eugenio Leone; Rita Nano; Alessandra Saccani; Paolo Monti; Paola Maffi; Giancarlo Bianchi; Antonio Sica; Giuseppe Peri; Raffaella Melzi; Luca Aldrighetti; Antonio Secchi; Valerio Di Carlo; Paola Allavena; Federico Bertuzzi
Diabetes January 2002, Vol.51, 55-65. doi:https://doi.org/10.2337/diabetes.51.1.55
β-Cell Death and Mass in Syngeneically Transplanted Islets Exposed to Short- and Long-Term Hyperglycemia
Diabetes January 2002, Vol.51, 66-72. doi:https://doi.org/10.2337/diabetes.51.1.66
Oral Exposure to Diabetes-Promoting Food or Immunomodulators in Neonates Alters Gut Cytokines and Diabetes
Diabetes January 2002, Vol.51, 73-78. doi:https://doi.org/10.2337/diabetes.51.1.73
A Distinct Th1 Immune Response Precedes the Described Th2 Response in Islet Xenograft Rejection
Diabetes January 2002, Vol.51, 79-86. doi:https://doi.org/10.2337/diabetes.51.1.79
Islet Study
Phosphatidylinositol 3-Kinase Suppresses Glucose-Stimulated Insulin Secretion by Affecting Post-Cytosolic [Ca2+] Elevation Signals
Kazuhiro Eto; Tokuyuki Yamashita; Yoshiharu Tsubamoto; Yasuo Terauchi; Kenzo Hirose; Naoto Kubota; Shigeo Yamashita; Junko Taka; Shinobu Satoh; Hisahiko Sekihara; Kazuyuki Tobe; Masamitsu Iino; Mitsuhiko Noda; Satoshi Kimura; Takashi Kadowaki
Diabetes January 2002, Vol.51, 87-97. doi:https://doi.org/10.2337/diabetes.51.1.87
A Key Role for β-Cell Cytosolic Phospholipase A2 in the Maintenance of Insulin Stores But Not in the Initiation of Insulin Secretion
Shanta J. Persaud; Helen M. Roderigo-Milne; Paul E. Squires; David Sugden; Caroline P.D. Wheeler-Jones; Phil J. Marsh; Véronique D. Belin; Melanie J. Luther; Peter M. Jones
Diabetes January 2002, Vol.51, 98-104. doi:https://doi.org/10.2337/diabetes.51.1.98
Intracellular pH Plays a Critical Role in Glucose-Induced Time-Dependent Potentiation of Insulin Release in Rat Islets
Diabetes January 2002, Vol.51, 105-113. doi:https://doi.org/10.2337/diabetes.51.1.105
Overexpression of Dominant-Negative Mutant Hepatocyte Nuclear Factor-1α in Pancreatic β-Cells Causes Abnormal Islet Architecture With Decreased Expression of E-Cadherin, Reduced β-cell Proliferation, and Diabetes
Kazuya Yamagata; Takao Nammo; Makoto Moriwaki; Arisa Ihara; Katsumi Iizuka; Qin Yang; Tomomi Satoh; Ming Li; Rikako Uenaka; Kohei Okita; Hiromi Iwahashi; Qian Zhu; Yang Cao; Akihisa Imagawa; Yoshihiro Tochino; Toshiaki Hanafusa; Jun-ichiro Miyagawa; Yuji Matsuzawa
Diabetes January 2002, Vol.51, 114-123. doi:https://doi.org/10.2337/diabetes.51.1.114
Ghrelin Is Present in Pancreatic α-Cells of Humans and Rats and Stimulates Insulin Secretion
Yukari Date; Masamitsu Nakazato; Suzuko Hashiguchi; Katsuya Dezaki; Muhtashan S. Mondal; Hiroshi Hosoda; Masayasu Kojima; Kenji Kangawa; Terukatsu Arima; Hisayuki Matsuo; Toshihiko Yada; Shigeru Matsukura
Diabetes January 2002, Vol.51, 124-129. doi:https://doi.org/10.2337/diabetes.51.1.124
Pathophysiology
Basal Insulin Gene Expression Significantly Improves Conventional Insulin Therapy in Type 1 Diabetic Rats
Diabetes January 2002, Vol.51, 130-138. doi:https://doi.org/10.2337/diabetes.51.1.130
Intrahepatic Mechanisms Underlying the Effect of Metformin in Decreasing Basal Glucose Production in Rats Fed a High-Fat Diet
Diabetes January 2002, Vol.51, 139-143. doi:https://doi.org/10.2337/diabetes.51.1.139
Insulin Resistance in Morbid Obesity: Reversal With Intramyocellular Fat Depletion
Aldo V. Greco; Gertrude Mingrone; Annalisa Giancaterini; Melania Manco; Manrico Morroni; Saverio Cinti; Marnie Granzotto; Roberto Vettor; Stefania Camastra; Ele Ferrannini
Diabetes January 2002, Vol.51, 144-151. doi:https://doi.org/10.2337/diabetes.51.1.144
Chronic Central Melanocortin-4 Receptor Antagonism and Central Neuropeptide-Y Infusion in Rats Produce Increased Adiposity by Divergent Pathways
Katherine Baran; Elaine Preston; Donna Wilks; Gregory J. Cooney; Edward W. Kraegen; Amanda Sainsbury
Diabetes January 2002, Vol.51, 152-158. doi:https://doi.org/10.2337/diabetes.51.1.152
Complication
Hyperglycemia-Induced Apoptosis in Human Umbilical Vein Endothelial Cells: Inhibition by the AMP-Activated Protein Kinase Activation
Diabetes January 2002, Vol.51, 159-167. doi:https://doi.org/10.2337/diabetes.51.1.159
Leptin Effect on Endothelial Nitric Oxide Is Mediated Through Akt–Endothelial Nitric Oxide Synthase Phosphorylation Pathway
Carmine Vecchione; Angelo Maffei; Salvatore Colella; Alessandra Aretini; Roberta Poulet; Giacomo Frati; Maria Teresa Gentile; Luigi Fratta; Valentina Trimarco; Bruno Trimarco; Giuseppe Lembo
Diabetes January 2002, Vol.51, 168-173. doi:https://doi.org/10.2337/diabetes.51.1.168
Overexpression of Metallothionein Reduces Diabetic Cardiomyopathy
Qiangrong Liang; Edward C. Carlson; Rajakumar V. Donthi; Patrica M. Kralik; Xia Shen; Paul N. Epstein
Diabetes January 2002, Vol.51, 174-181. doi:https://doi.org/10.2337/diabetes.51.1.174
Autocrine Activation of the IGF-I Signaling Pathway in Mesangial Cells Isolated From Diabetic NOD Mice
Diabetes January 2002, Vol.51, 182-188. doi:https://doi.org/10.2337/diabetes.51.1.182
The Effect of Dimethylbiguanide on Thrombin Activity, FXIII Activation, Fibrin Polymerization, and Fibrin Clot Formation
Kristina F. Standeven; Robert A.S. Ariëns; Paul Whitaker; Alison E. Ashcroft; John W. Weisel; Peter J. Grant
Diabetes January 2002, Vol.51, 189-197. doi:https://doi.org/10.2337/diabetes.51.1.189
High Glucose via Peroxynitrite Causes Tyrosine Nitration and Inactivation of Prostacyclin Synthase That Is Associated With Thromboxane/Prostaglandin H2 Receptor–Mediated Apoptosis and Adhesion Molecule Expression in Cultured Human Aortic Endothelial Cells
Diabetes January 2002, Vol.51, 198-203. doi:https://doi.org/10.2337/diabetes.51.1.198
Epidemiology
High Familial Risk and Genetic Susceptibility in Early Onset Childhood Diabetes
Diabetes January 2002, Vol.51, 210-214. doi:https://doi.org/10.2337/diabetes.51.1.210
PAX6 Mutation as a Genetic Factor Common to Aniridia and Glucose Intolerance
Tetsuyuki Yasuda; Yoshitaka Kajimoto; Yoshio Fujitani; Hirotaka Watada; Shuji Yamamoto; Takao Watarai; Yutaka Umayahara; Munehide Matsuhisa; Shin-ichi Gorogawa; Yasuaki Kuwayama; Yasuo Tano; Yoshimitsu Yamasaki; Masatsugu Hori
Diabetes January 2002, Vol.51, 224-230. doi:https://doi.org/10.2337/diabetes.51.1.224
SNP43 of CAPN10 and the Risk of Type 2 Diabetes in African-Americans: The Atherosclerosis Risk in Communities Study
Michael J. Garant; W.H. Linda Kao; Frederick Brancati; Josef Coresh; Tejal M. Rami; Craig L. Hanis; Eric Boerwinkle; Alan R. Shuldiner
Diabetes January 2002, Vol.51, 231-237. doi:https://doi.org/10.2337/diabetes.51.1.231
Brief Genetics Report
Chemokine Receptor Genotype Is Associated With Diabetic Nephropathy in Japanese With Type 2 Diabetes
Kunihiro Nakajima; Yasushi Tanaka; Takashi Nomiyama; Takeshi Ogihara; Lianshan Piao; Ken Sakai; Tomio Onuma; Ryuzo Kawamori
Diabetes January 2002, Vol.51, 238-242. doi:https://doi.org/10.2337/diabetes.51.1.238
A Novel Homozygous Missense Mutation of Melanocortin-4 Receptor (MC4R) in a Japanese Woman With Severe Obesity
Hiromasa Kobayashi; Yoshihiro Ogawa; Mitsuyo Shintani; Ken Ebihara; Makiko Shimodahira; Toshio Iwakura; Megumu Hino; Takashi Ishihara; Katsuji Ikekubo; Hiroyuki Kurahachi; Kazuwa Nakao
Diabetes January 2002, Vol.51, 243-246. doi:https://doi.org/10.2337/diabetes.51.1.243
Variation in the Calpain-10 Gene Affects Blood Glucose Levels in the British Population
Stephen Lynn; Julie C. Evans; Christopher White; Timothy M. Frayling; Andrew T. Hattersley; Doug M. Turnbull; Yukio Horikawa; Nancy J. Cox; Graeme I. Bell; Mark Walker
Diabetes January 2002, Vol.51, 247-250. doi:https://doi.org/10.2337/diabetes.51.1.247
The Angiotensin-Converting Enzyme DD Genotype Is Associated With Glomerulopathy Lesions in Type 2 Diabetes
Diabetes January 2002, Vol.51, 251-255. doi:https://doi.org/10.2337/diabetes.51.1.251
