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Issues
1 October 2002
ISSN 0012-1797
EISSN 1939-327X
Perspectives in Diabetes
Metabolic and Autocrine Regulation of the Mammalian Target of Rapamycin by Pancreatic β-Cells
Diabetes October 2002, Vol.51, 2877-2885. doi:https://doi.org/10.2337/diabetes.51.10.2877
Metabolism and Signal Transduction
AICAR Administration Causes an Apparent Enhancement of Muscle and Liver Insulin Action in Insulin-Resistant High-Fat-Fed Rats
Miguel A. Iglesias; Ji-Ming Ye; Georgia Frangioudakis; Asish K. Saha; Eva Tomas; Neil B. Ruderman; Gregory J. Cooney; Edward W. Kraegen
Diabetes October 2002, Vol.51, 2886-2894. doi:https://doi.org/10.2337/diabetes.51.10.2886
Troglitazone Antagonizes Metabolic Effects of Glucocorticoids in Humans: Effects on Glucose Tolerance, Insulin Sensitivity, Suppression of Free Fatty Acids, and Leptin
Steven M. Willi; Adele Kennedy; Penny Wallace; Elizabeth Ganaway; Nikki L. Rogers; W. Timothy Garvey
Diabetes October 2002, Vol.51, 2895-2902. doi:https://doi.org/10.2337/diabetes.51.10.2895
Effects of a Novel Glycogen Synthase Kinase-3 Inhibitor on Insulin-Stimulated Glucose Metabolism in Zucker Diabetic Fatty (fa/fa) Rats
Gary W. Cline; Kirk Johnson; Werner Regittnig; Pascale Perret; Effie Tozzo; Linda Xiao; Christine Damico; Gerald I. Shulman
Diabetes October 2002, Vol.51, 2903-2910. doi:https://doi.org/10.2337/diabetes.51.10.2903
Ghrelin Is Not Necessary for Adequate Hormonal Counterregulation of Insulin-Induced Hypoglycemia
Paola Lucidi; Giuseppe Murdolo; Chiara Di Loreto; Arianna De Cicco; Natascia Parlanti; Carmine Fanelli; Fausto Santeusanio; Geremia B. Bolli; Pierpaolo De Feo
Diabetes October 2002, Vol.51, 2911-2914. doi:https://doi.org/10.2337/diabetes.51.10.2911
Coordinated Regulation of Fat-Specific and Liver-Specific Glycerol Channels, Aquaporin Adipose and Aquaporin 9
Hiroshi Kuriyama; Iichiro Shimomura; Ken Kishida; Hidehiko Kondo; Naoki Furuyama; Hitoshi Nishizawa; Norikazu Maeda; Morihiro Matsuda; Hiroyuki Nagaretani; Shinji Kihara; Tadashi Nakamura; Yoshihiro Tochino; Tohru Funahashi; Yuji Matsuzawa
Diabetes October 2002, Vol.51, 2915-2921. doi:https://doi.org/10.2337/diabetes.51.10.2915
Polyunsaturated Fatty Acids and Acetoacetate Downregulate the Expression of the ATP-Binding Cassette Transporter A1
Yoshinari Uehara; Thomas Engel; Zhengchen Li; Christian Goepfert; Stephan Rust; Xiaoqin Zhou; Claus Langer; Christian Schachtrup; Johannes Wiekowski; Stefan Lorkowski; Gerd Assmann; Arnold von Eckardstein
Diabetes October 2002, Vol.51, 2922-2928. doi:https://doi.org/10.2337/diabetes.51.10.2922
Skeletal Muscle Insulin Resistance in Obesity-Associated Type 2 Diabetes in Monkeys Is Linked to a Defect in Insulin Activation of Protein Kinase C-ζ/λ/ι
Mary L. Standaert; Heidi K. Ortmeyer; Mini P. Sajan; Yoshinori Kanoh; Gautam Bandyopadhyay; Barbara C. Hansen; Robert V. Farese
Diabetes October 2002, Vol.51, 2936-2943. doi:https://doi.org/10.2337/diabetes.51.10.2936
Dysfunction of Mitochondria in Human Skeletal Muscle in Type 2 Diabetes
Diabetes October 2002, Vol.51, 2944-2950. doi:https://doi.org/10.2337/diabetes.51.10.2944
Obesity Studies
Removal of Visceral Fat Prevents Insulin Resistance and Glucose Intolerance of Aging: An Adipokine-Mediated Process?
Ilan Gabriely; Xiao Hui Ma; Xiao Man Yang; Gil Atzmon; Michael W. Rajala; Anders H. Berg; Phillip Scherer; Luciano Rossetti; Nir Barzilai
Diabetes October 2002, Vol.51, 2951-2958. doi:https://doi.org/10.2337/diabetes.51.10.2951
Effect of Weight Loss on Insulin Sensitivity and Intramuscular Long-Chain Fatty Acyl-CoAs in Morbidly Obese Subjects
Joseph A. Houmard; Charles J. Tanner; Chunli Yu; Paul G. Cunningham; Walter J. Pories; Kenneth G. MacDonald; Gerald I. Shulman
Diabetes October 2002, Vol.51, 2959-2963. doi:https://doi.org/10.2337/diabetes.51.10.2959
Low Plasma Adiponectin Concentrations Do Not Predict Weight Gain in Humans
Barbora Vozarova; Norbert Stefan; Robert S. Lindsay; Jonathan Krakoff; William C. Knowler; Tohru Funahashi; Yuji Matsuzawa; Michael Stumvoll; Christian Weyer; P. Antonio Tataranni
Diabetes October 2002, Vol.51, 2964-2967. doi:https://doi.org/10.2337/diabetes.51.10.2964
The Effect of Thiazolidinediones on Plasma Adiponectin Levels in Normal, Obese, and Type 2 Diabetic Subjects
Joseph G. Yu; Sandrine Javorschi; Andrea L. Hevener; Yolanta T. Kruszynska; Rodney A. Norman; Madhur Sinha; Jerrold M. Olefsky
Diabetes October 2002, Vol.51, 2968-2974. doi:https://doi.org/10.2337/diabetes.51.10.2968
Immunology and Transplantation
Thymectomy and Radiation-Induced Type 1 Diabetes in Nonlymphopenic BB Rats
Sheela Ramanathan; Marie-Therese Bihoreau; Andrew D. Paterson; Leili Marandi; Dominique Gauguier; Philippe Poussier
Diabetes October 2002, Vol.51, 2975-2981. doi:https://doi.org/10.2337/diabetes.51.10.2975
Islet Studies
Different Regulated Expression of the Tyrosine Phosphatase-Like Proteins IA-2 and Phogrin by Glucose and Insulin in Pancreatic Islets: Relationship to Development of Insulin Secretory Responses in Early Life
Kristian Löbner; Holger Steinbrenner; Graham A. Roberts; Zhidong Ling; Guo-Cai Huang; Sandra Piquer; Daniel G. Pipeleers; Jochen Seissler; Michael R. Christie
Diabetes October 2002, Vol.51, 2982-2988. doi:https://doi.org/10.2337/diabetes.51.10.2982
Role of NADH Shuttles in Glucose-Induced Insulin Secretion From Fetal β-Cells
Diabetes October 2002, Vol.51, 2989-2996. doi:https://doi.org/10.2337/diabetes.51.10.2989
Early, Selective, and Marked Loss of Sympathetic Nerves From the Islets of BioBreeder Diabetic Rats
Diabetes October 2002, Vol.51, 2997-3002. doi:https://doi.org/10.2337/diabetes.51.10.2997
Overexpression of Parathyroid Hormone-Related Protein Inhibits Pancreatic β-Cell Death In Vivo and In Vitro
Ana Cebrian; Adolfo García-Ocaña; Karen K. Takane; Darinka Sipula; Andrew F. Stewart; Rupangi C. Vasavada
Diabetes October 2002, Vol.51, 3003-3013. doi:https://doi.org/10.2337/diabetes.51.10.3003
Pathophysiology
Independent Association of Type 2 Diabetes and Coronary Artery Disease With Myocardial Insulin Resistance
Patricia Iozzo; Panithaya Chareonthaitawee; David Dutka; D. John Betteridge; Ele Ferrannini; Paolo G. Camici
Diabetes October 2002, Vol.51, 3020-3024. doi:https://doi.org/10.2337/diabetes.51.10.3020
Effects of Insulin Treatment in Type 2 Diabetic Patients on Intracellular Lipid Content in Liver and Skeletal Muscle
Christian Anderwald; Elisabeth Bernroider; Martin Krs̆s̆ák; Harald Stingl; Attila Brehm; Martin G. Bischof; Peter Nowotny; Michael Roden; Werner Waldhäusl
Diabetes October 2002, Vol.51, 3025-3032. doi:https://doi.org/10.2337/diabetes.51.10.3025
Insulin Sensitively Controls the Glucagon Response to Mild Hypoglycemia in the Dog
Diabetes October 2002, Vol.51, 3033-3042. doi:https://doi.org/10.2337/diabetes.51.10.3033
Free Fatty Acids Reduce Splanchnic and Peripheral Glucose Uptake in Patients With Type 2 Diabetes
Mandeep Bajaj; Thongchai Pratipanawatr; Rachele Berria; Wilailak Pratipanawatr; Sangeeta Kashyap; Kenneth Cusi; Lawrence Mandarino; Ralph A. DeFronzo
Diabetes October 2002, Vol.51, 3043-3048. doi:https://doi.org/10.2337/diabetes.51.10.3043
Complications
α-Tocopherol Decreases Superoxide Anion Release in Human Monocytes Under Hyperglycemic Conditions Via Inhibition of Protein Kinase C-α
Diabetes October 2002, Vol.51, 3049-3054. doi:https://doi.org/10.2337/diabetes.51.10.3049
Naltrexone, an Opioid Antagonist, Facilitates Reepithelialization of the Cornea in Diabetic Rat
Ian S. Zagon; Joe B. Jenkins; Joseph W. Sassani; James D. Wylie; Torre B. Ruth; Jamie L. Fry; C. Max Lang; Patricia J. McLaughlin
Diabetes October 2002, Vol.51, 3055-3062. doi:https://doi.org/10.2337/diabetes.51.10.3055
Evidence for a Matrix Metalloproteinase Induction/Activation System in Arterial Vasculature and Decreased Synthesis and Activity in Diabetes
Diabetes October 2002, Vol.51, 3063-3068. doi:https://doi.org/10.2337/diabetes.51.10.3063
Risk Factor Groupings Related to Insulin Resistance and Their Synergistic Effects on Subclinical Atherosclerosis: The Atherosclerosis Risk in Communities Study
Sherita Hill Golden; Aaron R. Folsom; Josef Coresh; A. Richey Sharrett; Moyses Szklo; Frederick Brancati
Diabetes October 2002, Vol.51, 3069-3076. doi:https://doi.org/10.2337/diabetes.51.10.3069
C-Peptide Exerts Beneficial Effects on Myocardial Blood Flow and Function in Patients With Type 1 Diabetes
Diabetes October 2002, Vol.51, 3077-3082. doi:https://doi.org/10.2337/diabetes.51.10.3077
Podocyte Number in Normotensive Type 1 Diabetic Patients With Albuminuria
Kathryn E. White; Rudolf W. Bilous; Sally M. Marshall; Meguid El Nahas; Giuseppe Remuzzi; Giampiero Piras; Salvatore De Cosmo; GianCarlo Viberti; on behalf of the European Study for the Prevention of Renal Disease in Type 1 Diabetes (ESPRIT)
Diabetes October 2002, Vol.51, 3083-3089. doi:https://doi.org/10.2337/diabetes.51.10.3083
Amelioration of Long-Term Renal Changes in Obese Type 2 Diabetic Mice by a Neutralizing Vascular Endothelial Growth Factor Antibody
Allan Flyvbjerg; Frederik Dagnæs-Hansen; An S. De Vriese; Bieke F. Schrijvers; Ronald G. Tilton; Ruth Rasch
Diabetes October 2002, Vol.51, 3090-3094. doi:https://doi.org/10.2337/diabetes.51.10.3090
Nitric Oxide Prevents Aldose Reductase Activation and Sorbitol Accumulation During Diabetes
Deepak Chandra; Elias B. Jackson; Kota V. Ramana; Rocky Kelley; Satish K. Srivastava; Aruni Bhatnagar
Diabetes October 2002, Vol.51, 3095-3101. doi:https://doi.org/10.2337/diabetes.51.10.3095
In Vivo Evidence for Increased Oxidation of Circulating LDL in Impaired Glucose Tolerance
Steffi Kopprasch; Jens Pietzsch; Eberhard Kuhlisch; Katja Fuecker; Theodora Temelkova-Kurktschiev; Markolf Hanefeld; Helmut Kühne; Ulrich Julius; Jürgen Graessler
Diabetes October 2002, Vol.51, 3102-3106. doi:https://doi.org/10.2337/diabetes.51.10.3102
Pericytes and the Pathogenesis of Diabetic Retinopathy
Hans-Peter Hammes; Jihong Lin; Oliver Renner; Moshe Shani; Andrea Lundqvist; Christer Betsholtz; Michael Brownlee; Urban Deutsch
Diabetes October 2002, Vol.51, 3107-3112. doi:https://doi.org/10.2337/diabetes.51.10.3107
Insulin Stimulates Long-Chain Fatty Acid Utilization by Rat Cardiac Myocytes Through Cellular Redistribution of FAT/CD36
Joost J.F.P. Luiken; Debby P.Y. Koonen; Jodil Willems; Antonio Zorzano; Christoph Becker; Yvan Fischer; Narendra N. Tandon; Ger J. van der Vusse; Arend Bonen; Jan F.C. Glatz
Diabetes October 2002, Vol.51, 3113-3119. doi:https://doi.org/10.2337/diabetes.51.10.3113
Epidemiology
Components of the “Metabolic Syndrome” and Incidence of Type 2 Diabetes
Diabetes October 2002, Vol.51, 3120-3127. doi:https://doi.org/10.2337/diabetes.51.10.3120
Genetics
A Polymorphism in the Glucocorticoid Receptor Gene, Which Decreases Sensitivity to Glucocorticoids In Vivo, Is Associated With Low Insulin and Cholesterol Levels
Elisabeth F.C. van Rossum; Jan W. Koper; Nannette A.T.M. Huizenga; André G. Uitterlinden; Joop A.M.J.L. Janssen; Albert O. Brinkmann; Diederick E. Grobbee; Frank H. de Jong; Cornelia M. van Duyn; Huibert A.P. Pols; Steven W.J. Lamberts
Diabetes October 2002, Vol.51, 3128-3134. doi:https://doi.org/10.2337/diabetes.51.10.3128
Brief Genetics Report
Variations in Insulin Secretion in Carriers of the E23K Variant in the KIR6.2 Subunit of the ATP-Sensitive K+ Channel in the β-Cell
Leen M. ‘t Hart; Timon W. van Haeften; Jacqueline M. Dekker; Martine Bot; Robert J. Heine; J. Antonie Maassen
Diabetes October 2002, Vol.51, 3135-3138. doi:https://doi.org/10.2337/diabetes.51.10.3135
