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Perspectives in Diabetes

While Tinkering With the β-Cell… Metabolic Regulatory Mechanisms and New Therapeutic Strategies: American Diabetes Association Lilly Lecture, 2001

Christopher B. Newgard

Abstracts

View articletitled, While Tinkering With the β-Cell… Metabolic Regulatory Mechanisms and New Therapeutic Strategies: American Diabetes Association Lilly Lecture, 2001

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Topics: adenoviruses , cell lines , cytokine , genes , glucose

Diabetes November 2002, Vol.51, 3141-3150. doi:https://doi.org/10.2337/diabetes.51.11.3141

Metabolism and Signal Transduction

Effects of Insulin Deficiency or Excess on Hepatic Gluconeogenic Flux During Glycogenolytic Inhibition in the Conscious Dog

Dale S. Edgerton; Sylvain Cardin; Catherine Pan; Doss Neal; Ben Farmer; Margaret Converse; Alan D. Cherrington.

Abstracts

View articletitled, Effects of Insulin Deficiency or Excess on Hepatic Gluconeogenic Flux During Glycogenolytic Inhibition in the Conscious Dog

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Topics: dog, domestic , glucose , insulin , hyperinsulinism

Diabetes November 2002, Vol.51, 3151-3162. doi:https://doi.org/10.2337/diabetes.51.11.3151

Altered Myocellular and Abdominal Fat Partitioning Predict Disturbance in Insulin Action in HIV Protease Inhibitor-Related Lipodystrophy

Seng Khee Gan; Katherine Samaras; Campbell H. Thompson; Edward W. Kraegen; Andrew Carr; David A. Cooper; Donald J. Chisholm

Abstracts

View articletitled, Altered Myocellular and Abdominal Fat Partitioning Predict Disturbance in Insulin Action in HIV Protease Inhibitor-Related Lipodystrophy

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Topics: abdomen , glucose , hiv protease , insulin , lipids

Diabetes November 2002, Vol.51, 3163-3169. doi:https://doi.org/10.2337/diabetes.51.11.3163

Impact of Duration of Infusion and Choice of Isotope Label on Isotope Recycling in Glucose Homeostasis

Stelios K. Tigas; Agneta L. Sunehag; Morey W. Haymond

Abstracts

View articletitled, Impact of Duration of Infusion and Choice of Isotope Label on Isotope Recycling in Glucose Homeostasis

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Topics: glucagon , glucose , infusion procedures , isotopes

Diabetes November 2002, Vol.51, 3170-3175. doi:https://doi.org/10.2337/diabetes.51.11.3170

Profiling Gene Transcription In Vivo Reveals Adipose Tissue as an Immediate Target of Tumor Necrosis Factor-α: Implications for Insulin Resistance

Hong Ruan; Philip D. G. Miles; Christine M. Ladd; Kenneth Ross; Todd R. Golub; Jerrold M. Olefsky; Harvey F. Lodish

Abstracts

View articletitled, Profiling Gene Transcription In Vivo Reveals Adipose Tissue as an Immediate Target of Tumor Necrosis Factor-α: Implications for Insulin Resistance

Supplementary data

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Topics: tumor necrosis factors , adipose tissue , infusion procedures , insulin resistance , insulin

Diabetes November 2002, Vol.51, 3176-3188. doi:https://doi.org/10.2337/diabetes.51.11.3176

Obesity Studies

Dissociation of Obesity and Impaired Glucose Disposal in Mice Overexpressing Acyl Coenzyme A:Diacylglycerol Acyltransferase 1 in White Adipose Tissue

Hubert C. Chen; Scot J. Stone; Ping Zhou; Kimberly K. Buhman; Robert V. Farese, Jr

Abstracts

View articletitled, Dissociation of Obesity and Impaired Glucose Disposal in Mice Overexpressing Acyl Coenzyme A:Diacylglycerol Acyltransferase 1 in White Adipose Tissue

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Topics: fatty-acid-binding protein, adipocyte , mice , obesity , triglycerides , glucose

Diabetes November 2002, Vol.51, 3189-3195. doi:https://doi.org/10.2337/diabetes.51.11.3189

Comparison of Central and Peripheral Administration of C75 on Food Intake, Body Weight, and Conditioned Taste Aversion

Deborah J. Clegg; Matt D. Wortman; Stephen C. Benoit; Charles C. McOsker; Randy J. Seeley

Abstracts

View articletitled, Comparison of Central and Peripheral Administration of C75 on Food Intake, Body Weight, and Conditioned Taste Aversion

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Topics: computed tomographic angiography , eating , rats , sodium intake , heat (physical force)

Diabetes November 2002, Vol.51, 3196-3201. doi:https://doi.org/10.2337/diabetes.51.11.3196

Immunology and Transplantation

The Role of Autoimmunity in Islet Allograft Destruction: Major Histocompatibility Complex Class II Matching Is Necessary for Autoimmune Destruction of Allogeneic Islet Transplants After T-Cell Costimulatory Blockade

Leila Makhlouf; Koji Kishimoto; Rex N. Smith; Reza Abdi; Maria Koulmanda; Henry J. Winn; Hugh Auchincloss, Jr; Mohamed H. Sayegh

Abstracts

View articletitled, The Role of Autoimmunity in Islet Allograft Destruction: Major Histocompatibility Complex Class II Matching Is Necessary for Autoimmune Destruction of Allogeneic Islet Transplants After T-Cell Costimulatory Blockade

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Topics: allografting , autoimmunity , mice , mice, inbred nod , t-lymphocytes

Diabetes November 2002, Vol.51, 3202-3210. doi:https://doi.org/10.2337/diabetes.51.11.3202

Islet Studies

Uncoupling Protein 2 Knockout Mice Have Enhanced Insulin Secretory Capacity After a High-Fat Diet

Jamie W. Joseph; Vasilij Koshkin; Chen-Yu Zhang; Jing Wang; Bradford B. Lowell; Catherine B. Chan; Michael B. Wheeler

Abstracts

View articletitled, Uncoupling Protein 2 Knockout Mice Have Enhanced Insulin Secretory Capacity After a High-Fat Diet

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Topics: diet , glucose , insulin , mice , pancreas

Diabetes November 2002, Vol.51, 3211-3219. doi:https://doi.org/10.2337/diabetes.51.11.3211

Vascularized Islet Cell Transplantation in Miniature Swine: Islet-Kidney Allografts Correct the Diabetic Hyperglycemia Induced by Total Pancreatectomy

Naoki Kumagai; John C. LaMattina; Chisako Kamano; Parsia A. Vagefi; Rolf N. Barth; John J. O’Neil; Shin Yamamoto; Shannon G. Moran; Ryu Utsugi; David H. Sachs; Kazuhiko Yamada

Abstracts

View articletitled, Vascularized Islet Cell Transplantation in Miniature Swine: Islet-Kidney Allografts Correct the Diabetic Hyperglycemia Induced by Total Pancreatectomy

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Topics: allografting , donors , hyperglycemia , insulin , islets of langerhans transplantation

Diabetes November 2002, Vol.51, 3220-3228. doi:https://doi.org/10.2337/diabetes.51.11.3220

Glucagon Is Required for Early Insulin-Positive Differentiation in the Developing Mouse Pancreas

Krishna Prasadan; Erica Daume; Barry Preuett; Troy Spilde; Amina Bhatia; Hiroyuki Kobayashi; Mark Hembree; Pradip Manna; George K. Gittes

Abstracts

View articletitled, Glucagon Is Required for Early Insulin-Positive Differentiation in the Developing Mouse Pancreas

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Topics: glucagon , insulin , pancreas , preproglucagon , embryo

Diabetes November 2002, Vol.51, 3229-3236. doi:https://doi.org/10.2337/diabetes.51.11.3229

Induction of Autoimmune Diabetes Through Insulin (but Not GAD65) DNA Vaccination in Nonobese Diabetic and in RIP-B7.1 Mice

Wolfram Karges; Klaus Pechhold; Sascha Al Dahouk; Ines Riegger; Matthias Rief; Andrea Wissmann; Reinhold Schirmbeck; Christoph Barth; Bernhard O. Boehm

Abstracts

View articletitled, Induction of Autoimmune Diabetes Through Insulin (but Not GAD65) DNA Vaccination in Nonobese Diabetic and in RIP-B7.1 Mice

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Topics: dna , insulin , mice , vaccination , mice, inbred nod

Diabetes November 2002, Vol.51, 3237-3244. doi:https://doi.org/10.2337/diabetes.51.11.3237

SERCA3 Ablation Does Not Impair Insulin Secretion but Suggests Distinct Roles of Different Sarcoendoplasmic Reticulum Ca²⁺ Pumps for Ca²⁺ Homeostasis in Pancreatic β-cells

Abdelilah Arredouani; Yves Guiot; Jean-Christophe Jonas; Lynne H. Liu; Myriam Nenquin; José A. Pertusa; Jacques Rahier; Jean-François Rolland; Gary E. Shull; Martine Stevens; Frank Wuytack; Jean-Claude Henquin; Patrick Gilon

Abstracts

View articletitled, SERCA3 Ablation Does Not Impair Insulin Secretion but Suggests Distinct Roles of Different Sarcoendoplasmic Reticulum Ca2+ Pumps for Ca2+ Homeostasis in Pancreatic β-cells

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Topics: ablation , glucose , insulin secretion , mice , insulin

Diabetes November 2002, Vol.51, 3245-3253. doi:https://doi.org/10.2337/diabetes.51.11.3245

The iddm4 Locus Segregates With Diabetes Susceptibility in Congenic WF.iddm4 Rats

John P. Mordes; Jean Leif; Stephen Novak; Cheryl DeScipio; Dale L. Greiner; Elizabeth P. Blankenhorn

Abstracts

View articletitled, The iddm4 Locus Segregates With Diabetes Susceptibility in Congenic WF.iddm4 Rats

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Topics: rats , alleles , homozygote

Diabetes November 2002, Vol.51, 3254-3262. doi:https://doi.org/10.2337/diabetes.51.11.3254

Pathophysiology

Prevention of Hypoglycemia Using Risk Assessment With a Continuous Glucose Monitoring System

Carine Choleau; Petr Dokladal; Jean-Claude Klein; W. Kenneth Ward; George S. Wilson; Gérard Reach

Abstracts

View articletitled, Prevention of Hypoglycemia Using Risk Assessment With a Continuous Glucose Monitoring System

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Topics: blood glucose , glucose , hypoglycemia

Diabetes November 2002, Vol.51, 3263-3273. doi:https://doi.org/10.2337/diabetes.51.11.3263

Complications

Reduction of the Accumulation of Advanced Glycation End Products by ACE Inhibition in Experimental Diabetic Nephropathy

Josephine M. Forbes; Mark E. Cooper; Vicki Thallas; Wendy C. Burns; Merlin C. Thomas; Gail C. Brammar; Fiona Lee; Sharon L. Grant; Louise M. Burrell; George Jerums; Tanya M. Osicka

Abstracts

View articletitled, Reduction of the Accumulation of Advanced Glycation End Products by ACE Inhibition in Experimental Diabetic Nephropathy

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Topics: 3-nitrotyrosine , angiotensin-converting enzyme inhibitors , attenuation , diabetic nephropathy , fluorescence

Diabetes November 2002, Vol.51, 3274-3282. doi:https://doi.org/10.2337/diabetes.51.11.3274

ALT-946 and Aminoguanidine, Inhibitors of Advanced Glycation, Improve Severe Nephropathy in the Diabetic Transgenic (mREN-2)27 Rat

Jennifer L. Wilkinson-Berka; Darren J. Kelly; Suzanne M. Koerner; Kassie Jaworski; Belinda Davis; Vicki Thallas; Mark E. Cooper

Abstracts

View articletitled, ALT-946 and Aminoguanidine, Inhibitors of Advanced Glycation, Improve Severe Nephropathy in the Diabetic Transgenic (mREN-2)27 Rat

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Topics: animals, transgenic , kidney , pimagedine , rats , tissue degeneration

Diabetes November 2002, Vol.51, 3283-3289. doi:https://doi.org/10.2337/diabetes.51.11.3283

Activation of Cyclin D1-Cdk4 and Cdk4-Directed Phosphorylation of RB Protein in Diabetic Mesangial Hypertrophy

Denis Féliers; Meredith A. Frank; Daniel J. Riley

Abstracts

View articletitled, Activation of Cyclin D1-Cdk4 and Cdk4-Directed Phosphorylation of RB Protein in Diabetic Mesangial Hypertrophy

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Topics: cyclin-dependent kinase 4 , cyclins , glucose , hypertrophy , retinoblastoma protein

Diabetes November 2002, Vol.51, 3290-3299. doi:https://doi.org/10.2337/diabetes.51.11.3290

Relationship of Phospholipid Transfer Protein Activity to HDL and Apolipoprotein B-Containing Lipoproteins in Subjects With and Without Type 1 Diabetes

Helen M. Colhoun; Marja-Riitta Taskinen; James D. Otvos; Paul van den Berg; John O’Connor; Arie Van Tol

Abstracts

View articletitled, Relationship of Phospholipid Transfer Protein Activity to HDL and Apolipoprotein B-Containing Lipoproteins in Subjects With and Without Type 1 Diabetes

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Topics: high density lipoproteins , lipoproteins , diabetes mellitus, type 1 , apolipoproteins b , phospholipid exchange proteins

Diabetes November 2002, Vol.51, 3300-3305. doi:https://doi.org/10.2337/diabetes.51.11.3300

Decreased Myocardial Perfusion Reserve in Diabetic Autonomic Neuropathy

Mustafa Taskiran; Thomas Fritz-Hansen; Verner Rasmussen; Henrik B.W. Larsson; Jannik Hilsted

Abstracts

View articletitled, Decreased Myocardial Perfusion Reserve in Diabetic Autonomic Neuropathy

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Topics: autonomic neuropathy , diabetic autonomic neuropathy , dipyridamole , fractional flow reserve, myocardial , myocardial perfusion

Diabetes November 2002, Vol.51, 3306-3310. doi:https://doi.org/10.2337/diabetes.51.11.3306

STAT5 Activation Induced by Diabetic LDL Depends on LDL Glycation and Occurs Via src Kinase Activity

Maria Felice Brizzi; Patrizia Dentelli; Roberto Gambino; Sara Cabodi; Maurizio Cassader; Ada Castelli; Paola Defilippi; Luigi Pegoraro; Gianfranco Pagano

Abstracts

View articletitled, STAT5 Activation Induced by Diabetic LDL Depends on LDL Glycation and Occurs Via src Kinase Activity

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Topics: low-density lipoproteins , phosphotransferases

Diabetes November 2002, Vol.51, 3311-3317. doi:https://doi.org/10.2337/diabetes.51.11.3311

Genetics

Linkage and Association With Type 1 Diabetes on Chromosome 1q42

Kathryn G. Ewens; Lindsey N. Johnson; Beth Wapelhorst; Kristin O’Brien; Sarah Gutin; V. Anne Morrison; Craig Street; Simon G. Gregory; Richard S. Spielman; Patrick Concannon

Abstracts

View articletitled, Linkage and Association With Type 1 Diabetes on Chromosome 1q42

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Topics: chromosome 1q42 , diabetes mellitus, type 1 , genetic linkage analysis , single nucleotide polymorphism , genes

Diabetes November 2002, Vol.51, 3318-3325. doi:https://doi.org/10.2337/diabetes.51.11.3318

No Association Between lck Gene Polymorphisms and Protein Level in Type 1 Diabetes

Solange Nervi; Sandra Nicodeme; Corinne Gartioux; Catherine Atlan; Marc Lathrop; Denis Reviron; Philippe Naquet; Fumihiko Matsuda; Jean Imbert; Bernard Vialettes

Abstracts

View articletitled, No Association Between lck Gene Polymorphisms and Protein Level in Type 1 Diabetes

Supplementary data

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Topics: diabetes mellitus, type 1 , genes , polymorphism , single nucleotide polymorphism , nucleotides

Diabetes November 2002, Vol.51, 3326-3330. doi:https://doi.org/10.2337/diabetes.51.11.3326

Brief Genetics Reports

A Functional Polymorphism in the Promoter of UCP2 Enhances Obesity Risk but Reduces Type 2 Diabetes Risk in Obese Middle-Aged Humans

Franz Krempler; Harald Esterbauer; Raimund Weitgasser; Christoph Ebenbichler; Josef R. Patsch; Karl Miller; Mingqiang Xie; Veronika Linnemayr; Hannes Oberkofler; Wolfgang Patsch

Abstracts

View articletitled, A Functional Polymorphism in the Promoter of UCP2 Enhances Obesity Risk but Reduces Type 2 Diabetes Risk in Obese Middle-Aged Humans

Supplementary data

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Topics: diabetes mellitus, type 2 , insulin , obesity , polymorphism , pax6 transcription factor

Diabetes November 2002, Vol.51, 3331-3335. doi:https://doi.org/10.2337/diabetes.51.11.3331

Association of IL4R Haplotypes With Type 1 Diabetes

Daniel B. Mirel; Ana Maria Valdes; Laura C. Lazzeroni; Rebecca L. Reynolds; Henry A. Erlich; Janelle A. Noble

Abstracts

View articletitled, Association of IL4R Haplotypes With Type 1 Diabetes

Supplementary data

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Topics: diabetes mellitus, type 1 , haplotypes , interleukin 4 receptor , single nucleotide polymorphism , alleles

Diabetes November 2002, Vol.51, 3336-3341. doi:https://doi.org/10.2337/diabetes.51.11.3336

Molecular Analysis of KCNJ10 on 1q as a Candidate Gene for Type 2 Diabetes in Pima Indians

Vidya S. Farook; Robert L. Hanson; Johanna K. Wolford; Clifton Bogardus; Michal Prochazka

Abstracts

View articletitled, Molecular Analysis of KCNJ10 on 1q as a Candidate Gene for Type 2 Diabetes in Pima Indians

Supplementary data

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Topics: candidate disease gene , diabetes mellitus, type 2 , kcnj10 gene , single nucleotide polymorphism , genome

Diabetes November 2002, Vol.51, 3342-3346. doi:https://doi.org/10.2337/diabetes.51.11.3342

Interleukin-18 Promoter Polymorphisms in Type 1 Diabetes

Adam Kretowski; Katarzyna Mironczuk; Anna Karpinska; Urszula Bojaryn; Maciej Kinalski; Zbigniew Puchalski; Ida Kinalska

Abstracts

View articletitled, Interleukin-18 Promoter Polymorphisms in Type 1 Diabetes

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Topics: diabetes mellitus, type 1 , interleukin-18 , polymorphism , genes

Diabetes November 2002, Vol.51, 3347-3349. doi:https://doi.org/10.2337/diabetes.51.11.3347

Erratum

Extract

View articletitled, Erratum

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Topics: guinea , hippocampus , glucose , chief complaint , cystic fibrosis

Diabetes November 2002, Vol.51, 3350. doi:https://doi.org/10.2337/diabetes.51.11.3350

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