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Issues
1 December 2002
ISSN 0012-1797
EISSN 1939-327X
Perspectives in Diabetes
The Rise of Childhood Type 1 Diabetes in the 20th Century
Topics:
child
,
diabetes mellitus, type 1
,
insulin
Diabetes December 2002, Vol.51, 3353-3361. doi:https://doi.org/10.2337/diabetes.51.12.3353
Metabolism and Signal Transduction
Identification of the Insulin-Regulated Interaction of Phosphodiesterase 3B With 14-3-3 β Protein
Hiroshi Onuma; Haruhiko Osawa; Kazuya Yamada; Takahiro Ogura; Fumiko Tanabe; Daryl K. Granner; Hideichi Makino
Topics:
adipocytes
,
insulin
,
serine
,
yeast one/two-hybrid system
,
phosphoric diester hydrolase
Diabetes December 2002, Vol.51, 3362-3367. doi:https://doi.org/10.2337/diabetes.51.12.3362
Lipolysis in the Absence of Hormone-Sensitive Lipase: Evidence for a Common Mechanism Regulating Distinct Lipases
Hiroaki Okazaki; Jun-ichi Osuga; Yoshiaki Tamura; Naoya Yahagi; Sachiko Tomita; Futoshi Shionoiri; Yoko Iizuka; Ken Ohashi; Kenji Harada; Satoshi Kimura; Takanari Gotoda; Hitoshi Shimano; Nobuhiro Yamada; Shun Ishibashi
Topics:
adipocytes
,
international organization for standardization
,
lipase
,
lipolysis
,
sterol esterase
Diabetes December 2002, Vol.51, 3368-3375. doi:https://doi.org/10.2337/diabetes.51.12.3368
Marked Heterogeneity of Human Skeletal Muscle Lipolysis at Rest
Eva Hagström-Toft; Veronica Qvisth; Inger Nennesmo; Mikael Rydén; Helene Bolinder; Staffan Enoksson; Jan Bolinder; Peter Arner
Topics:
biopsy
,
gastrocnemius muscle
,
glycerol
,
lipolysis
,
microdialysis
Diabetes December 2002, Vol.51, 3376-3383. doi:https://doi.org/10.2337/diabetes.51.12.3376
The Role of Insulin in Human Brain Glucose Metabolism: An 18Fluoro-Deoxyglucose Positron Emission Tomography Study
Emma M. Bingham; David Hopkins; Diarmuid Smith; Andrew Pernet; William Hallett; Laurence Reed; Paul K. Marsden; Stephanie A. Amiel
Topics:
brain
,
insulin
,
positron-emission tomography
,
glucose
,
fluorodeoxyglucose f18
Diabetes December 2002, Vol.51, 3384-3390. doi:https://doi.org/10.2337/diabetes.51.12.3384
Interleukin-6 Induces Cellular Insulin Resistance in Hepatocytes
Topics:
insulin
,
interleukin-6
,
hepatocytes
,
signal transduction
,
irs1 protein, human
Diabetes December 2002, Vol.51, 3391-3399. doi:https://doi.org/10.2337/diabetes.51.12.3391
Activating Transcription Factor-2 Mediates Transcriptional Regulation of Gluconeogenic Gene PEPCK by Retinoic Acid
Topics:
phosphoenolpyruvate carboxylase
,
phosphotransferases
,
dna
,
genes
Diabetes December 2002, Vol.51, 3400-3407. doi:https://doi.org/10.2337/diabetes.51.8.3400
Obesity Studies
Fasting Plasma Ghrelin Levels Are Negatively Correlated With Insulin Resistance and PAI-1, but Not With Leptin, in Obese Children and Adolescents
Ayako Ikezaki; Hiroshi Hosoda; Keiko Ito; Saika Iwama; Naoko Miura; Hisafumi Matsuoka; Chisato Kondo; Masayasu Kojima; Kenji Kangawa; Shigetaka Sugihara
Topics:
adolescent
,
childhood obesity
,
fasting
,
ghrelin
,
insulin resistance
Diabetes December 2002, Vol.51, 3408-3411. doi:https://doi.org/10.2337/diabetes.51.12.3408
The Rat Arcuate Nucleus Integrates Peripheral Signals Provided by Leptin, Insulin, and a Ghrelin Mimetic
Topics:
insulin
,
leptin
,
glucose
,
nucleus infundibularis hypothalami
,
rats, zucker
Diabetes December 2002, Vol.51, 3412-3419. doi:https://doi.org/10.2337/diabetes.51.12.3412
Y2 Receptor Deletion Attenuates the Type 2 Diabetic Syndrome of ob/ob Mice
Topics:
mice
,
obesity
,
mice, knockout
,
rna, messenger
,
neuropeptide y
Diabetes December 2002, Vol.51, 3420-3427. doi:https://doi.org/10.2337/diabetes.51.12.3420
Immunology and Transplantation
Intrahepatic Islet Transplantation in Type 1 Diabetic Patients Does Not Restore Hypoglycemic Hormonal Counterregulation or Symptom Recognition After Insulin Independence
Topics:
epinephrine
,
glucagon
,
hypoglycemia
,
hypoglycemic agents
,
insulin
Diabetes December 2002, Vol.51, 3428-3434. doi:https://doi.org/10.2337/diabetes.51.12.3428
Islet Studies
A Novel Approach to Increase Human Islet Cell Mass While Preserving β-Cell Function
Gillian M. Beattie; Anthony M.P. Montgomery; Ana D. Lopez; Ergeng Hao; Brandon Perez; Margaret L. Just; Jonathan R.T. Lakey; Marquis E. Hart; Alberto Hayek
Topics:
fibrin
,
gel
,
insulin
,
endocrine pancreas
,
growth factor
Diabetes December 2002, Vol.51, 3435-3439. doi:https://doi.org/10.2337/diabetes.51.12.3435
cAMP-Activated Protein Kinase-Independent Potentiation of Insulin Secretion by cAMP Is Impaired in SUR1 Null Islets
Mitsuhiro Nakazaki; Ana Crane; Min Hu; Victor Seghers; Susanne Ullrich; Lydia Aguilar-Bryan; Joseph Bryan
Topics:
cyclic amp
,
glucose
,
insulin
,
potentiation
,
insulin secretion
Diabetes December 2002, Vol.51, 3440-3449. doi:https://doi.org/10.2337/diabetes.51.12.3440
Exogenous Nitric Oxide and Endogenous Glucose-Stimulated β-Cell Nitric Oxide Augment Insulin Release
Topics:
glucose
,
insulin
,
insulin secretion
,
diagnostic imaging
Diabetes December 2002, Vol.51, 3450-3460. doi:https://doi.org/10.2337/diabetes.51.12.3450
Pathophysiology
Hyperglycemia Inhibits Capacitative Calcium Entry and Hypertrophy in Neonatal Cardiomyocytes
Topics:
angiotensin ii
,
hyperglycemia
,
thapsigargin
,
glucose
,
hypertrophy
Diabetes December 2002, Vol.51, 3461-3467. doi:https://doi.org/10.2337/diabetes.51.12.3461
The Relative Contributions of Birth Weight, Weight Change, and Current Weight to Insulin Resistance in Contemporary 5-Year-Olds: The EarlyBird Study
Terence J. Wilkin; Bradley S. Metcalf; Michael J. Murphy; Joanne Kirkby; Alison N. Jeffery; Linda D. Voss
Topics:
birth weight
,
body weight changes
,
insulin resistance
,
child
,
girls
Diabetes December 2002, Vol.51, 3468-3472. doi:https://doi.org/10.2337/diabetes.51.12.3468
Combined Effects of Genetic and Environmental Factors on Insulin Resistance Associated With Reduced Fetal Growth
Delphine Jaquet; David A. Trégouët; Thierry Godefroy; Viviane Nicaud; Didi Chevenne; Laurence Tiret; Paul Czernichow; Claire Lévy-Marchal
Topics:
alleles
,
body mass index procedure
,
environmental factors
,
fetal growth
,
genetics
Diabetes December 2002, Vol.51, 3473-3478. doi:https://doi.org/10.2337/diabetes.51.12.3473
Rosiglitazone but Not Metformin Enhances Insulin- and Exercise-Stimulated Skeletal Muscle Glucose Uptake in Patients With Newly Diagnosed Type 2 Diabetes
Kirsti Hällsten; Kirsi A. Virtanen; Fredrik Lönnqvist; Hannu Sipilä; Airi Oksanen; Tapio Viljanen; Tapani Rönnemaa; Jorma Viikari; Juhani Knuuti; Pirjo Nuutila
Topics:
diabetes mellitus, type 2
,
glucose
,
glucose uptake
,
insulin
,
metformin
Diabetes December 2002, Vol.51, 3479-3485. doi:https://doi.org/10.2337/diabetes.51.12.3479
Mechanisms of the Triglyceride- and Cholesterol-Lowering Effect of Fenofibrate in Hyperlipidemic Type 2 Diabetic Patients
Topics:
cholesterol
,
fenofibrate
,
rna, messenger
,
triglycerides
,
mononuclear cells
Diabetes December 2002, Vol.51, 3486-3491. doi:https://doi.org/10.2337/diabetes.51.12.3486
Insulin-Mediated Hemodynamic Changes Are Impaired in Muscle of Zucker Obese Rats
Michelle G. Wallis; Catherine M. Wheatley; Stephen Rattigan; Eugene J. Barrett; Andrew D.H. Clark; Michael G. Clark
Topics:
doppler hemodynamics
,
insulin
,
obesity
,
rats
,
rats, zucker
Diabetes December 2002, Vol.51, 3492-3498. doi:https://doi.org/10.2337/diabetes.51.12.3492
Complications
Early Complement Activation and Decreased Levels of Glycosylphosphatidylinositol-Anchored Complement Inhibitors in Human and Experimental Diabetic Retinopathy
Topics:
antigens, cd59
,
complement inhibitor
,
complement membrane attack complex
,
donors
,
retina
Diabetes December 2002, Vol.51, 3499-3504. doi:https://doi.org/10.2337/diabetes.51.12.3499
Inhibition of the JAK/STAT Signaling Pathway Prevents the High Glucose-Induced Increase in TGF-β and Fibronectin Synthesis in Mesangial Cells
Topics:
fibronectins
,
glucose
,
phosphorylation
,
stat1 gene
,
stat3 protein
Diabetes December 2002, Vol.51, 3505-3509. doi:https://doi.org/10.2337/diabetes.51.12.3505
All-trans Retinoic Acid Improves Structure and Function of Diabetic Rat Skin in Organ Culture
Topics:
organ culture techniques
,
skin
,
streptozocin
,
rats
,
fibroblasts
Diabetes December 2002, Vol.51, 3510-3516. doi:https://doi.org/10.2337/diabetes.51.12.3510
Endothelin Contributes to Basal Vascular Tone and Endothelial Dysfunction in Human Obesity and Type 2 Diabetes
Topics:
diabetes mellitus, type 2
,
endothelial dysfunction
,
endothelins
,
obesity
,
endothelin-1
Diabetes December 2002, Vol.51, 3517-3523. doi:https://doi.org/10.2337/diabetes.51.12.3517
Lower Heart Rate Variability Is Associated With the Development of Coronary Heart Disease in Individuals With Diabetes: The Atherosclerosis Risk in Communities (ARIC) Study
Topics:
aric trial
,
coronary heart disease
,
follow-up
,
heart failure
,
heart rate
Diabetes December 2002, Vol.51, 3524-3531. doi:https://doi.org/10.2337/diabetes.51.12.3524
Activation of Tubular Epithelial Cells in Diabetic Nephropathy
Michael Morcos; Ahmed A.R. Sayed; Angelika Bierhaus; Benito Yard; Rüdiger Waldherr; Wolfgang Merz; Ingrid Kloeting; Erwin Schleicher; Stefani Mentz; Randa F. Abd el Baki; Hans Tritschler; Michael Kasper; Vedat Schwenger; Andreas Hamann; Klaus A. Dugi; Anne-Marie Schmidt; David Stern; Reinhard Ziegler; Hans U. Haering; Martin Andrassy; Fokko van der Woude; Peter P. Nawroth
Topics:
albumins
,
antibodies
,
antigens
,
diabetic nephropathy
,
epithelial cells
Diabetes December 2002, Vol.51, 3532-3544. doi:https://doi.org/10.2337/diabetes.51.12.3532
Local Sympathetic Denervation in Painful Diabetic Neuropathy
Topics:
complex regional pain syndromes
,
diabetic neuropathies
,
foot
,
pain
,
positron-emission tomography
Diabetes December 2002, Vol.51, 3545-3553. doi:https://doi.org/10.2337/diabetes.51.12.3545
Genetics
FOXC2 mRNA Expression and a 5′ Untranslated Region Polymorphism of the Gene Are Associated With Insulin Resistance
Martin Ridderstråle; Emma Carlsson; Mia Klannemark; Anna Cederberg; Christina Kösters; Hans Tornqvist; Heidi Storgaard; Allan Vaag; Sven Enerbäck; Leif Groop
Topics:
foxc2 gene
,
insulin
,
insulin resistance
,
obesity
,
polymorphism
Diabetes December 2002, Vol.51, 3554-3560. doi:https://doi.org/10.2337/diabetes.51.12.3554
Variants Within the Calpain-10 Gene on Chromosome 2q37 (NIDDM1) and Relationships to Type 2 Diabetes, Insulin Resistance, and Impaired Acute Insulin Secretion Among Scandinavian Caucasians
Søren K. Rasmussen; Søren A. Urhammer; Lars Berglund; Jan N. Jensen; Lars Hansen; Søren M. Echwald; Knut Borch-Johnsen; Yukio Horikawa; Hirosato Mashima; Hans Lithell; Nancy J. Cox; Torben Hansen; Graeme I. Bell; Oluf Pedersen
Topics:
calpain 10
,
diabetes mellitus, type 2
,
fasting
,
glucose
,
haplotypes
Diabetes December 2002, Vol.51, 3561-3567. doi:https://doi.org/10.2337/diabetes.51.12.3561
A Quantitative Trait Locus Influencing Type 2 Diabetes Susceptibility Maps to a Region on 5q in an Extended French Family
Lisa J. Martin; Anthony G. Comuzzie; Sophie Dupont; Nathalie Vionnet; Christian Dina; Sophie Gallina; Mouna Houari; John Blangero; Philippe Froguel
Topics:
diabetes mellitus, type 2
,
quantitative trait loci
,
glucose
,
maps
,
genetic linkage analysis
Diabetes December 2002, Vol.51, 3568-3572. doi:https://doi.org/10.2337/diabetes.51.12.3568
Brief Genetics Reports
Sex-Related Bias and Exclusion Mapping of the Nonrecombinant Portion of Chromosome Y in Human Type 1 Diabetes in the Isolated Founder Population of Sardinia
Daniela Contu; Laura Morelli; Patrizia Zavattari; Rosanna Lampis; Efisio Angius; Paola Frongia; Daniela Murru; Mario Maioli; Paolo Francalacci; John A. Todd; Francesco Cucca
Topics:
diabetes mellitus, type 1
,
y chromosomes
,
genotype
Diabetes December 2002, Vol.51, 3573-3576. doi:https://doi.org/10.2337/diabetes.51.12.3573
Cellular Basis of Diabetic Nephropathy: II. The Transforming Growth Factor-β System and Diabetic Nephropathy Lesions in Type 1 Diabetes
Chunmei Huang; Youngki Kim; Maria Luiza A. Caramori; Alfred J. Fish; Stephen S. Rich; Michael E. Miller; Gregory B. Russell; Michael Mauer
Topics:
diabetes mellitus, type 1
,
diabetic nephropathy
,
reverse transcriptase polymerase chain reaction
,
rna
,
rna, messenger
Diabetes December 2002, Vol.51, 3577-3581. doi:https://doi.org/10.2337/diabetes.51.12.3577
Interleukin-1 Receptor Antagonist Genotype Is Associated With Coronary Atherosclerosis in Patients With Type 2 Diabetes
Rodrig Marculescu; Georg Endler; Martin Schillinger; Nelly Iordanova; Markus Exner; Evelyn Hayden; Kurt Huber; Oswald Wagner; Christine Mannhalter
Topics:
atherosclerosis
,
coronary arteriosclerosis
,
diabetes mellitus, type 2
,
interleukin-1 receptor antagonists
,
genes
Diabetes December 2002, Vol.51, 3582-3585. doi:https://doi.org/10.2337/diabetes.51.12.3582
PPARG F388L, a Transactivation-Deficient Mutant, in Familial Partial Lipodystrophy
Topics:
familial partial lipodystrophy
,
lipodystrophy
,
lmna gene
,
mutation
,
peroxisome proliferator-activated receptors
Diabetes December 2002, Vol.51, 3586-3590. doi:https://doi.org/10.2337/diabetes.51.12.3586
Erratum
Errata
Topics:
exocrine pancreas
,
pancreas
,
vesicular monoamine transporter 2
,
oxidopamine
,
glucagon
Diabetes December 2002, Vol.51, 3591. doi:https://doi.org/10.2337/diabetes.51.12.3591
Errata
Topics:
burns
,
color
,
diabetic nephropathy
,
glycosylation end products, advanced
Diabetes December 2002, Vol.51, 3592. doi:https://doi.org/10.2337/diabetes.51.12.3592
