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Issues
1 February 2002
ISSN 0012-1797
EISSN 1939-327X
Rapid Publication
Calcineurin Inhibitor–Free CD28 Blockade-Based Protocol Protects Allogeneic Islets in Nonhuman Primates
Andrew B. Adams; Nozomu Shirasugi; Megan M. Durham; Elizabeth Strobert; Dan Anderson; Phyllis Rees; Shannon Cowan; Huaying Xu; Yelena Blinder; Michael Cheung; Dianne Hollenbaugh; Norma S. Kenyon; Thomas C. Pearson; Christian P. Larsen
Diabetes February 2002, Vol.51, 265-270. doi:https://doi.org/10.2337/diabetes.51.2.265
Central Administration of Oleic Acid Inhibits Glucose Production and Food Intake
Diabetes February 2002, Vol.51, 271-275. doi:https://doi.org/10.2337/diabetes.51.2.271
Metabolism and Signal Transduction
Regulation of Pyruvate Dehydrogenase Kinase Expression by Peroxisome Proliferator–Activated Receptor-α Ligands, Glucocorticoids, and Insulin
Diabetes February 2002, Vol.51, 276-283. doi:https://doi.org/10.2337/diabetes.51.2.276
Transcriptional Regulation of Adipocyte Hormone-Sensitive Lipase by Glucose
Fatima Smih; Philippe Rouet; Stéphanie Lucas; Aline Mairal; Coralie Sengenes; Max Lafontan; Sophie Vaulont; Marta Casado; Dominique Langin
Diabetes February 2002, Vol.51, 293-300. doi:https://doi.org/10.2337/diabetes.51.2.293
Effects of Free Fatty Acids and Glycerol on Splanchnic Glucose Metabolism and Insulin Extraction in Nondiabetic Humans
Pankaj Shah; Adrian Vella; Ananda Basu; Rita Basu; Aron Adkins; W. Frederick Schwenk; C. Michael Johnson; K. Sreekumaran Nair; Michael D. Jensen; Robert A. Rizza
Diabetes February 2002, Vol.51, 301-310. doi:https://doi.org/10.2337/diabetes.51.2.301
Immunology and Transplantation
Interleukin-1 Plus γ-Interferon-Induced Pancreatic β-Cell Dysfunction Is Mediated by β-Cell Nitric Oxide Production
Diabetes February 2002, Vol.51, 311-316. doi:https://doi.org/10.2337/diabetes.51.2.311
Inhibition of Protein Kinase C δ Protects Rat INS-1 Cells Against Interleukin-1β and Streptozotocin-Induced Apoptosis
Diabetes February 2002, Vol.51, 317-324. doi:https://doi.org/10.2337/diabetes.51.2.317
A Reg Family Protein Is Overexpressed in Islets From a Patient With New-Onset Type 1 Diabetes and Acts as T-Cell Autoantigen in NOD Mice
Diabetes February 2002, Vol.51, 339-346. doi:https://doi.org/10.2337/diabetes.51.2.339
A Metalloporphyrin-Based Superoxide Dismutase Mimic Inhibits Adoptive Transfer of Autoimmune Diabetes by a Diabetogenic T-Cell Clone
Jon D. Piganelli; Sonia C. Flores; Coral Cruz; Jeffrey Koepp; Ines Batinic-Haberle; James Crapo; Brian Day; Remy Kachadourian; Rebekah Young; Brenda Bradley; Kathryn Haskins
Diabetes February 2002, Vol.51, 347-355. doi:https://doi.org/10.2337/diabetes.51.2.347
Indoleamine 2,3-Dioxygenase Expression in Transplanted NOD Islets Prolongs Graft Survival After Adoptive Transfer of Diabetogenic Splenocytes:
Angela M. Alexander; Megan Crawford; Suzanne Bertera; William A. Rudert; Osamu Takikawa; Paul D. Robbins; Massimo Trucco
Diabetes February 2002, Vol.51, 356-365. doi:https://doi.org/10.2337/diabetes.51.2.356
Islet Studies
Overexpression of the Na/Ca Exchanger Shapes Stimulus-Induced Cytosolic Ca2+ Oscillations in Insulin-Producing BRIN-BD11 Cells
Françoise Van Eylen; Oscar Diaz Horta; Aurore Barez; Adama Kamagate; Peter R. Flatt; Regina Macianskiene; Kanigula Mubagwa; André Herchuelz
Diabetes February 2002, Vol.51, 366-375. doi:https://doi.org/10.2337/diabetes.51.2.366
Feedback Control of the ATP-Sensitive K+ Current by Cytosolic Ca2+ Contributes to Oscillations of the Membrane Potential in Pancreatic β-Cells
Diabetes February 2002, Vol.51, 376-384. doi:https://doi.org/10.2337/diabetes.51.2.376
Endocrine Pancreas Development in Growth-Retarded Human Fetuses
Frédérique Béringue; Bertrand Blondeau; Marie Claire Castellotti; Bernadette Bréant; Paul Czernichow; Michel Polak
Diabetes February 2002, Vol.51, 385-391. doi:https://doi.org/10.2337/diabetes.51.2.385
Fetal Insulin-Like Growth Factor-2 Production Is Impaired in the GK Rat Model of Type 2 Diabetes
Patricia Serradas; Luis Goya; Matthieu Lacorne; Marie-Noëlle Gangnerau; Sonia Ramos; Carmen Alvarez; Ana-Maria Pascual-Leone; Bernard Portha
Diabetes February 2002, Vol.51, 392-397. doi:https://doi.org/10.2337/diabetes.51.2.392
Glucagon Replacement via Micro-Osmotic Pump Corrects Hypoglycemia and α-Cell Hyperplasia in Prohormone Convertase 2 Knockout Mice
Diabetes February 2002, Vol.51, 398-405. doi:https://doi.org/10.2337/diabetes.51.2.398
Miniglucagon (Glucagon 19-29): A Novel Regulator of the Pancreatic Islet Physiology
Stéphane Dalle; Ghislaine Fontés; Anne-Dominique Lajoix; Laurence LeBrigand; René Gross; Gérard Ribes; Michel Dufour; Léo Barry; Dung LeNguyen; Dominique Bataille
Diabetes February 2002, Vol.51, 406-412. doi:https://doi.org/10.2337/diabetes.51.2.406
Increased Expression of Antioxidant and Antiapoptotic Genes in Islets That May Contribute to β-Cell Survival During Chronic Hyperglycemia
D. Ross Laybutt; Hideaki Kaneto; Wendy Hasenkamp; Shane Grey; Jean-Christophe Jonas; Dennis C. Sgroi; Adam Groff; Christiane Ferran; Susan Bonner-Weir; Arun Sharma; Gordon C. Weir
Diabetes February 2002, Vol.51, 413-423. doi:https://doi.org/10.2337/diabetes.51.2.413
Bedtime Administration of NN2211, a Long-Acting GLP-1 Derivative, Substantially Reduces Fasting and Postprandial Glycemia in Type 2 Diabetes
Claus B. Juhl; Malene Hollingdal; Jeppe Sturis; Grethe Jakobsen; Henrik Agersø; Johannes Veldhuis; Niels Pørksen; Ole Schmitz
Diabetes February 2002, Vol.51, 424-429. doi:https://doi.org/10.2337/diabetes.51.2.424
Pathophysiology
Synaptic Adaptation to Repeated Hypoglycemia Depends on the Utilization of Monocarboxylates in Guinea Pig Hippocampal Slices
Diabetes February 2002, Vol.51, 430-438. doi:https://doi.org/10.2337/diabetes.51.2.430
The Concept of Selective Leptin Resistance: Evidence From Agouti Yellow Obese Mice
Marcelo L.G. Correia; William G. Haynes; Kamal Rahmouni; Donald A. Morgan; William I. Sivitz; Allyn L. Mark
Diabetes February 2002, Vol.51, 439-442. doi:https://doi.org/10.2337/diabetes.51.2.439
Troglitazone but not Metformin Restores Insulin-Stimulated Phosphoinositide 3-Kinase Activity and Increases p110β Protein Levels in Skeletal Muscle of Type 2 Diabetic Subjects
Young-Bum Kim; Theodore P. Ciaraldi; Alice Kong; Dennis Kim; Neelima Chu; Pharis Mohideen; Sunder Mudaliar; Robert R. Henry; Barbara B. Kahn
Diabetes February 2002, Vol.51, 443-448. doi:https://doi.org/10.2337/diabetes.51.2.443
Acyl-CoA Binding Protein Expression Is Fiber Type- Specific and Elevated in Muscles From the Obese Insulin-Resistant Zucker Rat
Diabetes February 2002, Vol.51, 449-454. doi:https://doi.org/10.2337/diabetes.51.2.449
High White Blood Cell Count Is Associated With a Worsening of Insulin Sensitivity and Predicts the Development of Type 2 Diabetes
Barbora Vozarova; Christian Weyer; Robert S. Lindsay; Richard E. Pratley; Clifton Bogardus; P. Antonio Tataranni
Diabetes February 2002, Vol.51, 455-461. doi:https://doi.org/10.2337/diabetes.51.2.455
Normalization of Plasma Glucose Concentration by Insulin Therapy Improves Insulin-Stimulated Glycogen Synthesis in Type 2 Diabetes
Thongchai Pratipanawatr; Kenneth Cusi; Peter Ngo; Wilailak Pratipanawatr; Lawrence J. Mandarino; Ralph A. DeFronzo
Diabetes February 2002, Vol.51, 462-468. doi:https://doi.org/10.2337/diabetes.51.2.462
Inclusion of Low Amounts of Fructose With an Intraduodenal Glucose Load Markedly Reduces Postprandial Hyperglycemia and Hyperinsulinemia in the Conscious Dog
Masakazu Shiota; Mary Courtney Moore; Pietro Galassetti; Michael Monohan; Doss W. Neal; Gerald I. Shulman; Alan D. Cherrington
Diabetes February 2002, Vol.51, 469-478. doi:https://doi.org/10.2337/diabetes.51.2.469
Insulin Signaling After Exercise in Insulin Receptor Substrate-2-Deficient Mice
Kirsten F. Howlett; Kei Sakamoto; Michael F. Hirshman; William G. Aschenbach; Matthew Dow; Morris F. White; Laurie J. Goodyear
Diabetes February 2002, Vol.51, 479-483. doi:https://doi.org/10.2337/diabetes.51.2.479
A Unique Defect in the Regulation of Visceral Fat Cell Lipolysis in the Polycystic Ovary Syndrome as an Early Link to Insulin Resistance
Ingvar Ek; Peter Arner; Mikael Rydén; Cecilia Holm; Anders Thörne; Johan Hoffstedt; Hans Wahrenberg
Diabetes February 2002, Vol.51, 484-492. doi:https://doi.org/10.2337/diabetes.51.2.484
Complications
Carotid Artery Intima-Media Thickness in Children With Type 1 Diabetes
Mikko J. Järvisalo; Anne Putto-Laurila; Laura Jartti; Terho Lehtimäki; Tiina Solakivi; Tapani Rönnemaa; Olli T. Raitakari
Diabetes February 2002, Vol.51, 493-498. doi:https://doi.org/10.2337/diabetes.51.2.493
Reversibility of Glucose-Induced Changes in Mesangial Cell Extracellular Matrix Depends on the Genetic Background
Diabetes February 2002, Vol.51, 499-505. doi:https://doi.org/10.2337/diabetes.51.2.499
Cellular Basis of Diabetic Nephropathy: 1. Study Design and Renal Structural-Functional Relationships in Patients With Long-Standing Type 1 Diabetes
M. Luiza Caramori; Youngki Kim; Chunmei Huang; Alfred J. Fish; Stephen S. Rich; Michael E. Miller; Greg Russell; Michael Mauer
Diabetes February 2002, Vol.51, 506-513. doi:https://doi.org/10.2337/diabetes.51.2.506
The Role of Poly(ADP-Ribose) Polymerase Activation in the Development of Myocardial and Endothelial Dysfunction in Diabetes
Diabetes February 2002, Vol.51, 514-521. doi:https://doi.org/10.2337/diabetes.51.2.514
Vascular NADH Oxidase Is Involved in Impaired Endothelium-Dependent Vasodilation in OLETF Rats, a Model of Type 2 Diabetes
Diabetes February 2002, Vol.51, 522-527. doi:https://doi.org/10.2337/diabetes.51.2.522
Genetics
Genetic Variation in the Gene Encoding Adiponectin Is Associated With an Increased Risk of Type 2 Diabetes in the Japanese Population
Kazuo Hara; Philippe Boutin; Yasumichi Mori; Kazuyuki Tobe; Christian Dina; Kazuki Yasuda; Toshimasa Yamauchi; Shuichi Otabe; Terumasa Okada; Kazuhiro Eto; Hiroko Kadowaki; Ryoko Hagura; Yasuo Akanuma; Yoshio Yazaki; Ryozo Nagai; Matsuo Taniyama; Koichi Matsubara; Madoka Yoda; Yasuko Nakano; Satoshi Kimura; Motowo Tomita; Satoshi Kimura; Chikako Ito; Philippe Froguel; Takashi Kadowaki
Diabetes February 2002, Vol.51, 536-540. doi:https://doi.org/10.2337/diabetes.51.2.536
A Genome-Wide Scan for Obesity in African-Americans
Xiaofeng Zhu; Richard S. Cooper; Amy Luke; Guanjie Chen; Xiaodong Wu; Donghui Kan; Aravinda Chakravarti; Alan Weder
Diabetes February 2002, Vol.51, 541-544. doi:https://doi.org/10.2337/diabetes.51.2.541
Asian-Specific HLA Haplotypes Reveal Heterogeneity of the Contribution of HLA-DR and -DQ Haplotypes to Susceptibility to Type 1 Diabetes.
Yumiko Kawabata; Hiroshi Ikegami; Yoshihiko Kawaguchi; Tomomi Fujisawa; Maki Shintani; Masaya Ono; Masanori Nishino; Yasuko Uchigata; Inkyu Lee; Toshio Ogihara
Diabetes February 2002, Vol.51, 545-551. doi:https://doi.org/10.2337/diabetes.51.2.545