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Issues
1 April 2002
ISSN 0012-1797
EISSN 1939-327X
Metabolism and Signal Transduction
Fructose Amplifies Counterregulatory Responses to Hypoglycemia in Humans
Diabetes April 2002, Vol.51, 893-900. doi:https://doi.org/10.2337/diabetes.51.4.893
Peroxisome Proliferator-Activated Receptor-α Regulates Fatty Acid Utilization in Primary Human Skeletal Muscle Cells
Deborah M. Muoio; James M. Way; Charles J. Tanner; Deborah A. Winegar; Steven A. Kliewer; Joseph A. Houmard; William E. Kraus; G. Lynis Dohm
Diabetes April 2002, Vol.51, 901-909. doi:https://doi.org/10.2337/diabetes.51.4.901
Thyroid Hormone Receptor Interacting Protein 3 (Trip3) Is a Novel Coactivator of Hepatocyte Nuclear Factor-4α
Hiromi Iwahashi; Kazuya Yamagata; Issei Yoshiuchi; Jungo Terasaki; Qin Yang; Kenji Fukui; Arisa Ihara; Qian Zhu; Takeshi Asakura; Yang Cao; Akihisa Imagawa; Mitsuyoshi Namba; Toshiaki Hanafusa; Jun-ichiro Miyagawa; Yuji Matsuzawa
Diabetes April 2002, Vol.51, 910-914. doi:https://doi.org/10.2337/diabetes.51.4.910
Independent Regulation of In Vivo Insulin Action on Glucose Versus K+ Uptake by Dietary Fat and K+ Content
Diabetes April 2002, Vol.51, 915-920. doi:https://doi.org/10.2337/diabetes.51.4.915
Orally Administered Leucine Enhances Protein Synthesis in Skeletal Muscle of Diabetic Rats in the Absence of Increases in 4E-BP1 or S6K1 Phosphorylation
Joshua C. Anthony; Ali K. Reiter; Tracy G. Anthony; Stephen J. Crozier; Charles H. Lang; David A. MacLean; Scot R. Kimball; Leonard S. Jefferson
Diabetes April 2002, Vol.51, 928-936. doi:https://doi.org/10.2337/diabetes.51.4.928
Indinavir Induces Acute and Reversible Peripheral Insulin Resistance in Rats
Diabetes April 2002, Vol.51, 937-942. doi:https://doi.org/10.2337/diabetes.51.4.937
Obesity Studies
Long-Term Treatment With the Dipeptidyl Peptidase IV Inhibitor P32/98 Causes Sustained Improvements in Glucose Tolerance, Insulin Sensitivity, Hyperinsulinemia, and β-Cell Glucose Responsiveness in VDF (fa/fa) Zucker Rats
J.A. Pospisilik; S.G. Stafford; H-U. Demuth; R. Brownsey; W. Parkhouse; D.T. Finegood; C.H.S. McIntosh; R.A. Pederson
Diabetes April 2002, Vol.51, 943-950. doi:https://doi.org/10.2337/diabetes.51.4.943
Intraislet Hyperinsulinemia Prevents the Glucagon Response to Hypoglycemia Despite an Intact Autonomic Response
Diabetes April 2002, Vol.51, 958-965. doi:https://doi.org/10.2337/diabetes.51.4.958
Activation of IRS-2—Mediated Signal Transduction by IGF-1, but not TGF-α or EGF, Augments Pancreatic β-Cell Proliferation
Melissa K. Lingohr; Lorna M. Dickson; Jill F. McCuaig; Sigrun R. Hugl; Daniel R. Twardzik; Christopher J. Rhodes
Diabetes April 2002, Vol.51, 966-976. doi:https://doi.org/10.2337/diabetes.51.4.966
Pulsatile Insulin Release From Islets Isolated From Three Subjects With Type 2 Diabetes
Diabetes April 2002, Vol.51, 988-993. doi:https://doi.org/10.2337/diabetes.51.4.988
Carbon Monoxide Protects Pancreatic β-Cells From Apoptosis and Improves Islet Function/Survival After Transplantation
Lukas Günther; Pascal O. Berberat; Manabu Haga; Sophie Brouard; R. Neal Smith; Miguel P. Soares; Fritz H. Bach; Edda Tobiasch
Diabetes April 2002, Vol.51, 994-999. doi:https://doi.org/10.2337/diabetes.51.4.994
Pathophysiology
Blood Letting in High-Ferritin Type 2 Diabetes : Effects on Insulin Sensitivity and β-Cell Function
José Manuel Fernández-Real; Georgina Peñarroja; Antoni Castro; Fernando García-Bragado; Ildefonso Hernández-Aguado; Wifredo Ricart
Diabetes April 2002, Vol.51, 1000-1004. doi:https://doi.org/10.2337/diabetes.51.4.1000
The Concurrent Accumulation of Intra-Abdominal and Subcutaneous Fat Explains the Association Between Insulin Resistance and Plasma Leptin Concentrations : Distinct Metabolic Effects of Two Fat Compartments
Miriam Cnop; Melinda J. Landchild; Josep Vidal; Peter J. Havel; Negar G. Knowles; Darcy R. Carr; Feng Wang; Rebecca L. Hull; Edward J. Boyko; Barbara M. Retzlaff; Carolyn E. Walden; Robert H. Knopp; Steven E. Kahn
Diabetes April 2002, Vol.51, 1005-1015. doi:https://doi.org/10.2337/diabetes.51.4.1005
Leptin Resistance During Aging Is Independent of Fat Mass
Diabetes April 2002, Vol.51, 1016-1021. doi:https://doi.org/10.2337/diabetes.51.4.1016
Assessment of Skeletal Muscle Triglyceride Content by 1H Nuclear Magnetic Resonance Spectroscopy in Lean and Obese Adolescents: Relationships to Insulin Sensitivity, Total Body Fat, and Central Adiposity
Ranjana Sinha; Sylvie Dufour; Kitt Falk Petersen; Vincent LeBon; Staffan Enoksson; Yong-Zhan Ma; Mary Savoye; Douglas L. Rothman; Gerald I. Shulman; Sonia Caprio
Diabetes April 2002, Vol.51, 1022-1027. doi:https://doi.org/10.2337/diabetes.51.4.1022
Specific Inhibition of PTEN Expression Reverses Hyperglycemia in Diabetic Mice
Madeline Butler; Robert A. McKay; Ian J. Popoff; William A. Gaarde; Donna Witchell; Susan F. Murray; Nicholas M. Dean; Sanjay Bhanot; Brett P. Monia
Diabetes April 2002, Vol.51, 1028-1034. doi:https://doi.org/10.2337/diabetes.51.4.1028
Human Obesity and Type 2 Diabetes Are Associated With Alterations in SREBP1 Isoform Expression That Are Reproduced Ex Vivo by Tumor Necrosis Factor-α
Ciaran Sewter; Dirk Berger; Robert V. Considine; Gema Medina; Justin Rochford; Theodore Ciaraldi; Robert Henry; Lynis Dohm; Jeffrey S. Flier; Stephen O’Rahilly; Antonio J. Vidal-Puig
Diabetes April 2002, Vol.51, 1035-1041. doi:https://doi.org/10.2337/diabetes.51.4.1035
Insulin Resistance, Defective Insulin Receptor Substrate 2—Associated Phosphatidylinositol-3′ Kinase Activation, and Impaired Atypical Protein Kinase C (ζ/λ) Activation in Myotubes From Obese Patients With Impaired Glucose Tolerance
Diabetes April 2002, Vol.51, 1052-1059. doi:https://doi.org/10.2337/diabetes.51.4.1052
Increased Glucocorticoid Receptor Expression in Human Skeletal Muscle Cells May Contribute to the Pathogenesis of the Metabolic Syndrome
Christopher B. Whorwood; Stephen J. Donovan; Daniel Flanagan; David I.W. Phillips; Christopher D. Byrne
Diabetes April 2002, Vol.51, 1066-1075. doi:https://doi.org/10.2337/diabetes.51.4.1066
Acute Hyperglycemia Induces Nitrotyrosine Formation and Apoptosis in Perfused Heart From Rat
Antonio Ceriello; Lisa Quagliaro; Michele D’Amico; Clara Di Filippo; Raffaele Marfella; Francesco Nappo; Liberato Berrino; Francesco Rossi; Dario Giugliano
Diabetes April 2002, Vol.51, 1076-1082. doi:https://doi.org/10.2337/diabetes.51.4.1076
A Tailored Therapy for the Metabolic Syndrome : The Dual Peroxisome Proliferator-Activated Receptor-α/γ Agonist LY465608 Ameliorates Insulin Resistance and Diabetic Hyperglycemia While Improving Cardiovascular Risk Factors in Preclinical Models
Garret J. Etgen; Brian A. Oldham; William T. Johnson; Carol L. Broderick; Chahrzad R. Montrose; Joseph T. Brozinick; Elizabeth A. Misener; James S. Bean; William R. Bensch; Dawn A. Brooks; Anthony J. Shuker; Christopher J. Rito; James R. McCarthy; Robert J. Ardecky; John S. Tyhonas; Sharon L. Dana; James M. Bilakovics; James R. Paterniti, Jr; Kathleen M. Ogilvie; Sha Liu; Raymond F. Kauffman
Diabetes April 2002, Vol.51, 1083-1087. doi:https://doi.org/10.2337/diabetes.51.4.1083
Low Production Capacity of Interleukin-10 Associates With the Metabolic Syndrome and Type 2 Diabetes : The Leiden 85-Plus Study
Eric van Exel; Jacobijn Gussekloo; Anton J.M. de Craen; Marijke Frölich; Annetje Bootsma-van der Wiel; Rudi G.J. Westendorp
Diabetes April 2002, Vol.51, 1088-1092. doi:https://doi.org/10.2337/diabetes.51.4.1088
Modulation of Adipose Tissue Expression of Murine Matrix Metalloproteinases and Their Tissue Inhibitors With Obesity
Diabetes April 2002, Vol.51, 1093-1101. doi:https://doi.org/10.2337/diabetes.51.4.1093
Decreased Expression of Heat Shock Protein 72 In Skeletal Muscle of Patients With Type 2 Diabetes Correlates With Insulin Resistance
Istvan Kurucz; Ágota Morva; Allan Vaag; Karl-Fredrik Eriksson; Xudong Huang; Leif Groop; Laszlo Koranyi
Diabetes April 2002, Vol.51, 1102-1109. doi:https://doi.org/10.2337/diabetes.51.4.1102
Complications
Xanthine Oxidase Is Involved in Free Radical Production in Type 1 Diabetes: Protection by Allopurinol
Marí-Carmen Desco; Miguel Asensi; Rafael Márquez; José Martínez-Valls; Máximo Vento; Federico V. Pallardó; Juan Sastre; José Viña
Diabetes April 2002, Vol.51, 1118-1124. doi:https://doi.org/10.2337/diabetes.51.4.1118
Dose-Dependent Vasodilating Effects of Insulin on Adenosine-Stimulated Myocardial Blood Flow
Jan Sundell; Pirjo Nuutila; Hanna Laine; Matti Luotolahti; Kari Kalliokoski; Olli Raitakari; Juhani Knuuti
Diabetes April 2002, Vol.51, 1125-1130. doi:https://doi.org/10.2337/diabetes.51.4.1125
Lipid Infusion Impairs Physiologic Insulin-Mediated Capillary Recruitment and Muscle Glucose Uptake In Vivo
Diabetes April 2002, Vol.51, 1138-1145. doi:https://doi.org/10.2337/diabetes.51.4.1138
Flux Through the Hexosamine Pathway Is a Determinant of Nuclear Factor κB– Dependent Promoter Activation
Diabetes April 2002, Vol.51, 1146-1156. doi:https://doi.org/10.2337/diabetes.51.4.1146
Increased Urinary Albumin Excretion, Endothelial Dysfunction, and Chronic Low-Grade Inflammation in Type 2 Diabetes: Progressive, Interrelated, and Independently Associated With Risk of Death
Coen D.A. Stehouwer; Mari-Anne Gall; Jos W.R. Twisk; Elisabeth Knudsen; Jef J. Emeis; Hans-Henrik Parving
Diabetes April 2002, Vol.51, 1157-1165. doi:https://doi.org/10.2337/diabetes.51.4.1157
Overexpression of the Sarcoplasmic Reticulum Ca2+-ATPase Improves Myocardial Contractility in Diabetic Cardiomyopathy
Susanne U. Trost; Darrell D. Belke; Wolfgang F. Bluhm; Markus Meyer; Eric Swanson; Wolfgang H. Dillmann
Diabetes April 2002, Vol.51, 1166-1171. doi:https://doi.org/10.2337/diabetes.51.4.1166
Caspase Activation in Retinas of Diabetic and Galactosemic Mice and Diabetic Patients
Diabetes April 2002, Vol.51, 1172-1179. doi:https://doi.org/10.2337/diabetes.51.4.1172
Homocysteine Induces Protein Kinase C Activation and Stimulates c-Fos and Lipoprotein Lipase Expression in Macrophages
Diabetes April 2002, Vol.51, 1180-1187. doi:https://doi.org/10.2337/diabetes.51.4.1180
Altered Phosphodiesterase 3-Mediated cAMP Hydrolysis Contributes to a Hypermotile Phenotype in Obese JCR:LA-cp Rat Aortic Vascular Smooth Muscle Cells: Implications for Diabetes-Associated Cardiovascular Disease
Stuart J. Netherton; Sandra L. Jimmo; Daniel Palmer; Douglas G. Tilley; Heather A. Dunkerley; Daniel R. Raymond; James C. Russell; P. Marlene Absher; E. Helene Sage; Robert B. Vernon; Donald H. Maurice
Diabetes April 2002, Vol.51, 1194-1200. doi:https://doi.org/10.2337/diabetes.51.4.1194
ATP-Dependent K+ Channels Contribute to Local Metabolic Coronary Vasodilation in Experimental Diabetes
Diabetes April 2002, Vol.51, 1201-1207. doi:https://doi.org/10.2337/diabetes.51.4.1201
A Common Promoter Polymorphism in the Hepatic Lipase Gene (LIPC-480C>T) Is Associated With an Increase in Coronary Calcification in Type 1 Diabetes
John E. Hokanson; Suzanne Cheng; Janet K. Snell-Bergeon; Bonnie A. Fijal; Michael A. Grow; Chi Hung; Henry A. Erlich; James Ehrlich; Robert H. Eckel; Marian Rewers
Diabetes April 2002, Vol.51, 1208-1213. doi:https://doi.org/10.2337/diabetes.51.4.1208
Difference in Ischemic Regulation of Vascular Endothelial Growth Factor and Pigment Epithelium--Derived Factor in Brown Norway and Sprague Dawley Rats Contributing to Different Susceptibilities to Retinal Neovascularization
Diabetes April 2002, Vol.51, 1218-1225. doi:https://doi.org/10.2337/diabetes.51.4.1218
Abnormalities of Glucose Metabolism in Patients With Early Renal Failure
Diabetes April 2002, Vol.51, 1226-1232. doi:https://doi.org/10.2337/diabetes.51.4.1226
Genetics
The Second Activating Glucokinase Mutation (A456V): Implications for Glucose Homeostasis and Diabetes Therapy
Henrik B.T. Christesen; Bendt B. Jacobsen; Stella Odili; Carol Buettger; Antonio Cuesta-Munoz; Torben Hansen; Klaus Brusgaard; Ornella Massa; Mark A. Magnuson; Chiyo Shiota; Franz M. Matschinsky; Fabrizio Barbetti
Diabetes April 2002, Vol.51, 1240-1246. doi:https://doi.org/10.2337/diabetes.51.4.1240
Genome-Wide Search for Type 2 Diabetes in Japanese Affected Sib-Pairs Confirms Susceptibility Genes on 3q, 15q, and 20q and Identifies Two New Candidate Loci on 7p and 11p
Yasumichi Mori; Shuichi Otabe; Christian Dina; Kazuki Yasuda; Céline Populaire; Cécile Lecoeur; Vincent Vatin; Emmanuelle Durand; Kazuo Hara; Terumasa Okada; Kazuyuki Tobe; Philippe Boutin; Takashi Kadowaki; Philippe Froguel
Diabetes April 2002, Vol.51, 1247-1255. doi:https://doi.org/10.2337/diabetes.51.4.1247
Epidemiology
Type 2 Diabetes, APOE Gene, and the Risk for Dementia and Related Pathologies: The Honolulu-Asia Aging Study
Diabetes April 2002, Vol.51, 1256-1262. doi:https://doi.org/10.2337/diabetes.51.4.1256
Increased Proinsulin Levels and Decreased Acute Insulin Response Independently Predict the Incidence of Type 2 Diabetes in the Insulin Resistance Atherosclerosis Study
Anthony J.G. Hanley; Ralph D’Agostino, Jr.; Lynne E. Wagenknecht; Mohammed F. Saad; Peter J. Savage; Richard Bergman; Steven M. Haffner
Diabetes April 2002, Vol.51, 1263-1270. doi:https://doi.org/10.2337/diabetes.51.4.1263
Early Differential Defects of Insulin Secretion and Action in 19-Year-Old Caucasian Men Who Had Low Birth Weight
Diabetes April 2002, Vol.51, 1271-1280. doi:https://doi.org/10.2337/diabetes.51.4.1271
Brief Genetics Reports
Peroxisome Proliferator-Activated Receptor-γ Coactivator-1 Gene Locus: Associations With Obesity Indices in Middle-Aged Women
Harald Esterbauer; Hannes Oberkofler; Veronika Linnemayr; Bernhard Iglseder; Margot Hedegger; Peter Wolfsgruber; Bernhard Paulweber; Gerd Fastner; Franz Krempler; Wolfgang Patsch
Diabetes April 2002, Vol.51, 1281-1286. doi:https://doi.org/10.2337/diabetes.51.4.1281
Association Studies of Genetic Variation in the WFS1 Gene and Type 2 Diabetes in U.K. Populations
Jayne A.L. Minton; Andrew T. Hattersley; Katharine Owen; Mark I. McCarthy; Mark Walker; Farida Latif; Timothy Barrett; Timothy M. Frayling
Diabetes April 2002, Vol.51, 1287-1290. doi:https://doi.org/10.2337/diabetes.51.4.1287
Molecular Analysis of Berardinelli-Seip Congenital Lipodystrophy in Oman: Evidence for Multiple Loci
Kirsten Heathcote; Anna Rajab; Jocelyne Magré; Petros Syrris; Mehran Besti; Michael Patton; Marc Délépine; Mark Lathrop; Jacqueline Capeau; Steve Jeffery
Diabetes April 2002, Vol.51, 1291-1293. doi:https://doi.org/10.2337/diabetes.51.4.1291
