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Metabolism and Signal Transduction

Fructose Amplifies Counterregulatory Responses to Hypoglycemia in Humans

Ilan Gabriely; Meredith Hawkins; Cristian Vilcu; Luciano Rossetti; Harry Shamoon

Abstracts

View articletitled, Fructose Amplifies Counterregulatory Responses to Hypoglycemia in Humans

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Topics: fructose , glucose , hypoglycemia , infusion procedures , plasma

Diabetes April 2002, Vol.51, 893-900. doi:https://doi.org/10.2337/diabetes.51.4.893

Peroxisome Proliferator-Activated Receptor-α Regulates Fatty Acid Utilization in Primary Human Skeletal Muscle Cells

Deborah M. Muoio; James M. Way; Charles J. Tanner; Deborah A. Winegar; Steven A. Kliewer; Joseph A. Houmard; William E. Kraus; G. Lynis Dohm

Abstracts

View articletitled, Peroxisome Proliferator-Activated Receptor-α Regulates Fatty Acid Utilization in Primary Human Skeletal Muscle Cells

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Topics: fatty acids , lipids , peroxisome proliferator-activated receptors , skeletal myocytes , transluminal attenuation gradient

Diabetes April 2002, Vol.51, 901-909. doi:https://doi.org/10.2337/diabetes.51.4.901

Thyroid Hormone Receptor Interacting Protein 3 (Trip3) Is a Novel Coactivator of Hepatocyte Nuclear Factor-4α

Hiromi Iwahashi; Kazuya Yamagata; Issei Yoshiuchi; Jungo Terasaki; Qin Yang; Kenji Fukui; Arisa Ihara; Qian Zhu; Takeshi Asakura; Yang Cao; Akihisa Imagawa; Mitsuyoshi Namba; Toshiaki Hanafusa; Jun-ichiro Miyagawa; Yuji Matsuzawa

Abstracts

View articletitled, Thyroid Hormone Receptor Interacting Protein 3 (Trip3) Is a Novel Coactivator of Hepatocyte Nuclear Factor-4α

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Topics: cloning , diabetes mellitus, type 2 , dna, complementary , genes , hepatocytes

Diabetes April 2002, Vol.51, 910-914. doi:https://doi.org/10.2337/diabetes.51.4.910

Independent Regulation of In Vivo Insulin Action on Glucose Versus K⁺ Uptake by Dietary Fat and K⁺ Content

Cheol S. Choi; Felix N. Lee; Alicia A. McDonough; Jang H. Youn

Abstracts

View articletitled, Independent Regulation of In Vivo Insulin Action on Glucose Versus K+ Uptake by Dietary Fat and K+ Content

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Topics: dietary fats , glucose , insulin , diet , glucose uptake

Diabetes April 2002, Vol.51, 915-920. doi:https://doi.org/10.2337/diabetes.51.4.915

The Diabetic Phenotype Is Conserved in Myotubes Established From Diabetic Subjects: Evidence for Primary Defects in Glucose Transport and Glycogen Synthase Activity

Michael Gaster; Ingrid Petersen; Kurt Højlund; Pernille Poulsen; Henning Beck-Nielsen

Abstracts

View articletitled, The Diabetic Phenotype Is Conserved in Myotubes Established From Diabetic Subjects: Evidence for Primary Defects in Glucose Transport and Glycogen Synthase Activity

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Topics: cell culture techniques , glucose , glucose transport , glycogen , insulin

Diabetes April 2002, Vol.51, 921-927. doi:https://doi.org/10.2337/diabetes.51.4.921

Orally Administered Leucine Enhances Protein Synthesis in Skeletal Muscle of Diabetic Rats in the Absence of Increases in 4E-BP1 or S6K1 Phosphorylation

Joshua C. Anthony; Ali K. Reiter; Tracy G. Anthony; Stephen J. Crozier; Charles H. Lang; David A. MacLean; Scot R. Kimball; Leonard S. Jefferson

Abstracts

View articletitled, Orally Administered Leucine Enhances Protein Synthesis in Skeletal Muscle of Diabetic Rats in the Absence of Increases in 4E-BP1 or S6K1 Phosphorylation

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Topics: insulin , leucine , phosphorylation , protein biosynthesis , rats

Diabetes April 2002, Vol.51, 928-936. doi:https://doi.org/10.2337/diabetes.51.4.928

Indinavir Induces Acute and Reversible Peripheral Insulin Resistance in Rats

Paul W. Hruz; Haruhiko Murata; Haijun Qiu; Mike Mueckler

Abstracts

View articletitled, Indinavir Induces Acute and Reversible Peripheral Insulin Resistance in Rats

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Topics: glucose , indinavir , insulin , insulin resistance , rats

Diabetes April 2002, Vol.51, 937-942. doi:https://doi.org/10.2337/diabetes.51.4.937

Obesity Studies

Long-Term Treatment With the Dipeptidyl Peptidase IV Inhibitor P32/98 Causes Sustained Improvements in Glucose Tolerance, Insulin Sensitivity, Hyperinsulinemia, and β-Cell Glucose Responsiveness in VDF (fa/fa) Zucker Rats

J.A. Pospisilik; S.G. Stafford; H-U. Demuth; R. Brownsey; W. Parkhouse; D.T. Finegood; C.H.S. McIntosh; R.A. Pederson

Abstracts

View articletitled, Long-Term Treatment With the Dipeptidyl Peptidase IV Inhibitor P32/98 Causes Sustained Improvements in Glucose Tolerance, Insulin Sensitivity, Hyperinsulinemia, and β-Cell Glucose Responsiveness in VDF (fa/fa) Zucker Rats

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Topics: blood glucose , glucose , glucose tolerance , insulin , insulin sensitivity

Diabetes April 2002, Vol.51, 943-950. doi:https://doi.org/10.2337/diabetes.51.4.943

Impaired β-Cell Function, Incretin Effect, and Glucagon Suppression in Patients With Type 1 Diabetes Who Have Normal Fasting Glucose

Carla J. Greenbaum; Ronald L. Prigeon; David A. D’Alessio

Abstracts

View articletitled, Impaired β-Cell Function, Incretin Effect, and Glucagon Suppression in Patients With Type 1 Diabetes Who Have Normal Fasting Glucose

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Topics: diabetes mellitus, type 1 , diphtheria-tetanus-pertussis vaccine , fasting blood glucose measurement , glucagon , glucose

Diabetes April 2002, Vol.51, 951-957. doi:https://doi.org/10.2337/diabetes.51.4.951

Intraislet Hyperinsulinemia Prevents the Glucagon Response to Hypoglycemia Despite an Intact Autonomic Response

Salomon Banarer; Veronica P. McGregor; Philip E. Cryer

Abstracts

View articletitled, Intraislet Hyperinsulinemia Prevents the Glucagon Response to Hypoglycemia Despite an Intact Autonomic Response

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Topics: glucagon , hyperinsulinism , hypoglycemia , infusion procedures , insulin

Diabetes April 2002, Vol.51, 958-965. doi:https://doi.org/10.2337/diabetes.51.4.958

Activation of IRS-2—Mediated Signal Transduction by IGF-1, but not TGF-α or EGF, Augments Pancreatic β-Cell Proliferation

Melissa K. Lingohr; Lorna M. Dickson; Jill F. McCuaig; Sigrun R. Hugl; Daniel R. Twardzik; Christopher J. Rhodes

Abstracts

View articletitled, Activation of IRS-2—Mediated Signal Transduction by IGF-1, but not TGF-α or EGF, Augments Pancreatic β-Cell Proliferation

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Topics: glucose , insulin-like growth factor i , phosphorylation , signal transduction , irs1 protein, human

Diabetes April 2002, Vol.51, 966-976. doi:https://doi.org/10.2337/diabetes.51.4.966

Expression Profiling of Palmitate- and Oleate-Regulated Genes Provides Novel Insights Into the Effects of Chronic Lipid Exposure on Pancreatic β-Cell Function

Anna K. Busch; Damien Cordery; Gareth S. Denyer; Trevor J. Biden

Abstracts

View articletitled, Expression Profiling of Palmitate- and Oleate-Regulated Genes Provides Novel Insights Into the Effects of Chronic Lipid Exposure on Pancreatic β-Cell Function

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Topics: genes , glucose , lipids , palmitates , insulin

Diabetes April 2002, Vol.51, 977-987. doi:https://doi.org/10.2337/diabetes.51.4.977

Pulsatile Insulin Release From Islets Isolated From Three Subjects With Type 2 Diabetes

Jian-Man Lin; Marta E. Fabregat; Ramon Gomis; Peter Bergsten

Abstracts

View articletitled, Pulsatile Insulin Release From Islets Isolated From Three Subjects With Type 2 Diabetes

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Topics: diabetes mellitus, type 2 , insulin , glucose , tolbutamide

Diabetes April 2002, Vol.51, 988-993. doi:https://doi.org/10.2337/diabetes.51.4.988

Carbon Monoxide Protects Pancreatic β-Cells From Apoptosis and Improves Islet Function/Survival After Transplantation

Lukas Günther; Pascal O. Berberat; Manabu Haga; Sophie Brouard; R. Neal Smith; Miguel P. Soares; Fritz H. Bach; Edda Tobiasch

Abstracts

View articletitled, Carbon Monoxide Protects Pancreatic β-Cells From Apoptosis and Improves Islet Function/Survival After Transplantation

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Topics: antiapoptotic agents , apoptosis , carbon monoxide , mice , transplantation

Diabetes April 2002, Vol.51, 994-999. doi:https://doi.org/10.2337/diabetes.51.4.994

Pathophysiology

Blood Letting in High-Ferritin Type 2 Diabetes : Effects on Insulin Sensitivity and β-Cell Function

José Manuel Fernández-Real; Georgina Peñarroja; Antoni Castro; Fernando García-Bragado; Ildefonso Hernández-Aguado; Wifredo Ricart

Abstracts

View articletitled, Blood Letting in High-Ferritin Type 2 Diabetes : Effects on Insulin Sensitivity and β-Cell Function

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Topics: diabetes mellitus, type 2 , hyperferritinemia , insulin sensitivity , phlebotomy , serum ferritin level result

Diabetes April 2002, Vol.51, 1000-1004. doi:https://doi.org/10.2337/diabetes.51.4.1000

The Concurrent Accumulation of Intra-Abdominal and Subcutaneous Fat Explains the Association Between Insulin Resistance and Plasma Leptin Concentrations : Distinct Metabolic Effects of Two Fat Compartments

Miriam Cnop; Melinda J. Landchild; Josep Vidal; Peter J. Havel; Negar G. Knowles; Darcy R. Carr; Feng Wang; Rebecca L. Hull; Edward J. Boyko; Barbara M. Retzlaff; Carolyn E. Walden; Robert H. Knopp; Steven E. Kahn

Abstracts

View articletitled, The Concurrent Accumulation of Intra-Abdominal and Subcutaneous Fat Explains the Association Between Insulin Resistance and Plasma Leptin Concentrations : Distinct Metabolic Effects of Two Fat Compartments

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Topics: body fat distribution , insulin , insulin resistance , insulin sensitivity , leptin

Diabetes April 2002, Vol.51, 1005-1015. doi:https://doi.org/10.2337/diabetes.51.4.1005

Leptin Resistance During Aging Is Independent of Fat Mass

Ilan Gabriely; Xiao Hui Ma; Xiao Man Yang; Luciano Rossetti; Nir Barzilai

Abstracts

View articletitled, Leptin Resistance During Aging Is Independent of Fat Mass

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Topics: leptin , aging , rats , insulin

Diabetes April 2002, Vol.51, 1016-1021. doi:https://doi.org/10.2337/diabetes.51.4.1016

Assessment of Skeletal Muscle Triglyceride Content by ¹H Nuclear Magnetic Resonance Spectroscopy in Lean and Obese Adolescents: Relationships to Insulin Sensitivity, Total Body Fat, and Central Adiposity

Ranjana Sinha; Sylvie Dufour; Kitt Falk Petersen; Vincent LeBon; Staffan Enoksson; Yong-Zhan Ma; Mary Savoye; Douglas L. Rothman; Gerald I. Shulman; Sonia Caprio

Abstracts

View articletitled, Assessment of Skeletal Muscle Triglyceride Content by 1H Nuclear Magnetic Resonance Spectroscopy in Lean and Obese Adolescents: Relationships to Insulin Sensitivity, Total Body Fat, and Central Adiposity

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Topics: adolescent , body fat , insulin sensitivity , lipids , obesity

Diabetes April 2002, Vol.51, 1022-1027. doi:https://doi.org/10.2337/diabetes.51.4.1022

Specific Inhibition of PTEN Expression Reverses Hyperglycemia in Diabetic Mice

Madeline Butler; Robert A. McKay; Ian J. Popoff; William A. Gaarde; Donna Witchell; Susan F. Murray; Nicholas M. Dean; Sanjay Bhanot; Brett P. Monia

Abstracts

View articletitled, Specific Inhibition of PTEN Expression Reverses Hyperglycemia in Diabetic Mice

Supplementary data

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Topics: insulin , mice , proto-oncogene proteins c-akt , pten gene , oligonucleotides

Diabetes April 2002, Vol.51, 1028-1034. doi:https://doi.org/10.2337/diabetes.51.4.1028

Human Obesity and Type 2 Diabetes Are Associated With Alterations in SREBP1 Isoform Expression That Are Reproduced Ex Vivo by Tumor Necrosis Factor-α

Ciaran Sewter; Dirk Berger; Robert V. Considine; Gema Medina; Justin Rochford; Theodore Ciaraldi; Robert Henry; Lynis Dohm; Jeffrey S. Flier; Stephen O’Rahilly; Antonio J. Vidal-Puig

Abstracts

View articletitled, Human Obesity and Type 2 Diabetes Are Associated With Alterations in SREBP1 Isoform Expression That Are Reproduced Ex Vivo by Tumor Necrosis Factor-α

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Topics: adipocytes , insulin , obesity , protein isoforms , rna, messenger

Diabetes April 2002, Vol.51, 1035-1041. doi:https://doi.org/10.2337/diabetes.51.4.1035

Novel Genes Regulated by the Insulin Sensitizer Rosiglitazone During Adipocyte Differentiation

Tatjana Albrektsen; Klaus Stensgaard Frederiksen; William E. Holmes; Esper Boel; Karen Taylor; Jan Fleckner

Abstracts

View articletitled, Novel Genes Regulated by the Insulin Sensitizer Rosiglitazone During Adipocyte Differentiation

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Topics: adipocytes , differential display technique , genes , northern blotting , peroxisome proliferator-activated receptors

Diabetes April 2002, Vol.51, 1042-1051. doi:https://doi.org/10.2337/diabetes.51.4.1042

Insulin Resistance, Defective Insulin Receptor Substrate 2—Associated Phosphatidylinositol-3′ Kinase Activation, and Impaired Atypical Protein Kinase C (ζ/λ) Activation in Myotubes From Obese Patients With Impaired Glucose Tolerance

Peter Vollenweider; Barbara Ménard; Pascal Nicod

Abstracts

View articletitled, Insulin Resistance, Defective Insulin Receptor Substrate 2—Associated Phosphatidylinositol-3′ Kinase Activation, and Impaired Atypical Protein Kinase C (ζ/λ) Activation in Myotubes From Obese Patients With Impaired Glucose Tolerance

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Topics: 1-phosphatidylinositol 3-kinase , insulin , insulin receptor , insulin resistance , irs1 protein, human

Diabetes April 2002, Vol.51, 1052-1059. doi:https://doi.org/10.2337/diabetes.51.4.1052

Troglitazone Downregulates Δ-6 Desaturase Gene Expression in Human Skeletal Muscle Cell Cultures

Hans Günther Wahl; Christiana Kausch; Fausto Machicao; Kristian Rett; Michael Stumvoll; Hans-Ulrich Häring

Abstracts

View articletitled, Troglitazone Downregulates Δ-6 Desaturase Gene Expression in Human Skeletal Muscle Cell Cultures

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Topics: fatty acids , rna, messenger , troglitazone , reverse transcriptase polymerase chain reaction , skeletal myocytes

Diabetes April 2002, Vol.51, 1060-1065. doi:https://doi.org/10.2337/diabetes.51.4.1060

Increased Glucocorticoid Receptor Expression in Human Skeletal Muscle Cells May Contribute to the Pathogenesis of the Metabolic Syndrome

Christopher B. Whorwood; Stephen J. Donovan; Daniel Flanagan; David I.W. Phillips; Christopher D. Byrne

Abstracts

View articletitled, Increased Glucocorticoid Receptor Expression in Human Skeletal Muscle Cells May Contribute to the Pathogenesis of the Metabolic Syndrome

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Topics: glucocorticoid receptors , glucocorticoids , glucose , hydrocortisone , metabolic syndrome x

Diabetes April 2002, Vol.51, 1066-1075. doi:https://doi.org/10.2337/diabetes.51.4.1066

Acute Hyperglycemia Induces Nitrotyrosine Formation and Apoptosis in Perfused Heart From Rat

Antonio Ceriello; Lisa Quagliaro; Michele D’Amico; Clara Di Filippo; Raffaele Marfella; Francesco Nappo; Liberato Berrino; Francesco Rossi; Dario Giugliano

Abstracts

View articletitled, Acute Hyperglycemia Induces Nitrotyrosine Formation and Apoptosis in Perfused Heart From Rat

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Topics: 3-nitrotyrosine , apoptosis , glucose , glutathione , heart

Diabetes April 2002, Vol.51, 1076-1082. doi:https://doi.org/10.2337/diabetes.51.4.1076

A Tailored Therapy for the Metabolic Syndrome : The Dual Peroxisome Proliferator-Activated Receptor-α/γ Agonist LY465608 Ameliorates Insulin Resistance and Diabetic Hyperglycemia While Improving Cardiovascular Risk Factors in Preclinical Models

Abstracts

View articletitled, A Tailored Therapy for the Metabolic Syndrome : The Dual Peroxisome Proliferator-Activated Receptor-α/γ Agonist LY465608 Ameliorates Insulin Resistance and Diabetic Hyperglycemia While Improving Cardiovascular Risk Factors in Preclinical Models

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Topics: agonists , heart disease risk factors , high density lipoprotein cholesterol , hyperglycemia , insulin

Diabetes April 2002, Vol.51, 1083-1087. doi:https://doi.org/10.2337/diabetes.51.4.1083

Low Production Capacity of Interleukin-10 Associates With the Metabolic Syndrome and Type 2 Diabetes : The Leiden 85-Plus Study

Eric van Exel; Jacobijn Gussekloo; Anton J.M. de Craen; Marijke Frölich; Annetje Bootsma-van der Wiel; Rudi G.J. Westendorp

Abstracts

View articletitled, Low Production Capacity of Interleukin-10 Associates With the Metabolic Syndrome and Type 2 Diabetes : The Leiden 85-Plus Study

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Topics: diabetes mellitus, type 2 , interleukin-10 , metabolic syndrome x , hemoglobin a, glycosylated , tumor necrosis factors

Diabetes April 2002, Vol.51, 1088-1092. doi:https://doi.org/10.2337/diabetes.51.4.1088

Modulation of Adipose Tissue Expression of Murine Matrix Metalloproteinases and Their Tissue Inhibitors With Obesity

Erik Maquoi; Carine Munaut; Alain Colige; Désiré Collen; H. Roger Lijnen

Abstracts

View articletitled, Modulation of Adipose Tissue Expression of Murine Matrix Metalloproteinases and Their Tissue Inhibitors With Obesity

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Topics: adipocytes , adipose tissue , matrix metalloproteinases , mice , obesity

Diabetes April 2002, Vol.51, 1093-1101. doi:https://doi.org/10.2337/diabetes.51.4.1093

Decreased Expression of Heat Shock Protein 72 In Skeletal Muscle of Patients With Type 2 Diabetes Correlates With Insulin Resistance

Istvan Kurucz; Ágota Morva; Allan Vaag; Karl-Fredrik Eriksson; Xudong Huang; Leif Groop; Laszlo Koranyi

Abstracts

View articletitled, Decreased Expression of Heat Shock Protein 72 In Skeletal Muscle of Patients With Type 2 Diabetes Correlates With Insulin Resistance

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Topics: biopsy , diabetes mellitus, type 2 , heat-shock proteins , insulin , insulin resistance

Diabetes April 2002, Vol.51, 1102-1109. doi:https://doi.org/10.2337/diabetes.51.4.1102

Thiazolidinedione Treatment Normalizes Insulin Resistance and Ischemic Injury in the Zucker Fatty Rat Heart

Robert J. Sidell; Mark A. Cole; Nicholas J. Draper; Martine Desrois; Robin E. Buckingham; Kieran Clarke

Abstracts

View articletitled, Thiazolidinedione Treatment Normalizes Insulin Resistance and Ischemic Injury in the Zucker Fatty Rat Heart

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Topics: heart , insulin , ischemia , obesity , rosiglitazone

Diabetes April 2002, Vol.51, 1110-1117. doi:https://doi.org/10.2337/diabetes.51.4.1110

Complications

Xanthine Oxidase Is Involved in Free Radical Production in Type 1 Diabetes: Protection by Allopurinol

Marí-Carmen Desco; Miguel Asensi; Rafael Márquez; José Martínez-Valls; Máximo Vento; Federico V. Pallardó; Juan Sastre; José Viña

Abstracts

View articletitled, Xanthine Oxidase Is Involved in Free Radical Production in Type 1 Diabetes: Protection by Allopurinol

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Topics: allopurinol , diabetes mellitus, type 1 , liver , oxidative stress , xanthine oxidase

Diabetes April 2002, Vol.51, 1118-1124. doi:https://doi.org/10.2337/diabetes.51.4.1118

Dose-Dependent Vasodilating Effects of Insulin on Adenosine-Stimulated Myocardial Blood Flow

Jan Sundell; Pirjo Nuutila; Hanna Laine; Matti Luotolahti; Kari Kalliokoski; Olli Raitakari; Juhani Knuuti

Abstracts

View articletitled, Dose-Dependent Vasodilating Effects of Insulin on Adenosine-Stimulated Myocardial Blood Flow

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Topics: adenosine , infusion procedures , insulin , myocardial perfusion , hyperinsulinism

Diabetes April 2002, Vol.51, 1125-1130. doi:https://doi.org/10.2337/diabetes.51.4.1125

Elevated Levels of Acute-Phase Proteins and Plasminogen Activator Inhibitor-1 Predict the Development of Type 2 Diabetes: The Insulin Resistance Atherosclerosis Study

Andreas Festa; Ralph D’Agostino, Jr; Russell P. Tracy; Steven M. Haffner

Abstracts

View articletitled, Elevated Levels of Acute-Phase Proteins and Plasminogen Activator Inhibitor-1 Predict the Development of Type 2 Diabetes: The Insulin Resistance Atherosclerosis Study

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Topics: c-reactive protein , diabetes mellitus, type 2 , fibrinogen , plasminogen activator inhibitor 1 , insulin resistance

Diabetes April 2002, Vol.51, 1131-1137. doi:https://doi.org/10.2337/diabetes.51.4.1131

Lipid Infusion Impairs Physiologic Insulin-Mediated Capillary Recruitment and Muscle Glucose Uptake In Vivo

Lucy H. Clerk; Stephen Rattigan; Michael G. Clark

Abstracts

View articletitled, Lipid Infusion Impairs Physiologic Insulin-Mediated Capillary Recruitment and Muscle Glucose Uptake In Vivo

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Topics: blood capillaries , glucose , glucose uptake , infusion procedures , insulin

Diabetes April 2002, Vol.51, 1138-1145. doi:https://doi.org/10.2337/diabetes.51.4.1138

Flux Through the Hexosamine Pathway Is a Determinant of Nuclear Factor κB– Dependent Promoter Activation

Leighton R. James; Damu Tang; Alistair Ingram; Hao Ly; Kerri Thai; Lu Cai; James W. Scholey

Abstracts

View articletitled, Flux Through the Hexosamine Pathway Is a Determinant of Nuclear Factor κB– Dependent Promoter Activation

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Topics: cardiac support procedures , glucosamine , glucose , hexosamines , mast-cell sarcoma

Diabetes April 2002, Vol.51, 1146-1156. doi:https://doi.org/10.2337/diabetes.51.4.1146

Increased Urinary Albumin Excretion, Endothelial Dysfunction, and Chronic Low-Grade Inflammation in Type 2 Diabetes: Progressive, Interrelated, and Independently Associated With Risk of Death

Coen D.A. Stehouwer; Mari-Anne Gall; Jos W.R. Twisk; Elisabeth Knudsen; Jef J. Emeis; Hans-Henrik Parving

Abstracts

View articletitled, Increased Urinary Albumin Excretion, Endothelial Dysfunction, and Chronic Low-Grade Inflammation in Type 2 Diabetes: Progressive, Interrelated, and Independently Associated With Risk of Death

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Topics: albumins , c-reactive protein , diabetes mellitus, type 2 , endothelial dysfunction , endothelium

Diabetes April 2002, Vol.51, 1157-1165. doi:https://doi.org/10.2337/diabetes.51.4.1157

Overexpression of the Sarcoplasmic Reticulum Ca²⁺-ATPase Improves Myocardial Contractility in Diabetic Cardiomyopathy

Susanne U. Trost; Darrell D. Belke; Wolfgang F. Bluhm; Markus Meyer; Eric Swanson; Wolfgang H. Dillmann

Abstracts

View articletitled, Overexpression of the Sarcoplasmic Reticulum Ca2+-ATPase Improves Myocardial Contractility in Diabetic Cardiomyopathy

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Topics: diabetic cardiomyopathy , mice , sarcoplasmic reticulum calcium-transporting atpase 2a , heart , myocardial contraction

Diabetes April 2002, Vol.51, 1166-1171. doi:https://doi.org/10.2337/diabetes.51.4.1166

Caspase Activation in Retinas of Diabetic and Galactosemic Mice and Diabetic Patients

Susanne Mohr; Xia Xi; Jie Tang; Timothy S. Kern

Abstracts

View articletitled, Caspase Activation in Retinas of Diabetic and Galactosemic Mice and Diabetic Patients

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Topics: caspases , retina , mice

Diabetes April 2002, Vol.51, 1172-1179. doi:https://doi.org/10.2337/diabetes.51.4.1172

Homocysteine Induces Protein Kinase C Activation and Stimulates c-Fos and Lipoprotein Lipase Expression in Macrophages

Marie-Claude Beauchamp; Geneviève Renier

Abstracts

View articletitled, Homocysteine Induces Protein Kinase C Activation and Stimulates c-Fos and Lipoprotein Lipase Expression in Macrophages

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Topics: c-fos genes , rna, messenger , macrophages , homocysteine , lipoprotein lipase

Diabetes April 2002, Vol.51, 1180-1187. doi:https://doi.org/10.2337/diabetes.51.4.1180

Polymorphism in Ecto-Nucleotide Pyrophosphatase/Phosphodiesterase 1 Gene (ENPP1/PC-1) and Early Development of Advanced Diabetic Nephropathy in Type 1 Diabetes

Luis H. Canani; Daniel P.K. Ng; Adam Smiles; John J. Rogus; James H. Warram; Andrzej S. Krolewski

Abstracts

View articletitled, Polymorphism in Ecto-Nucleotide Pyrophosphatase/Phosphodiesterase 1 Gene (ENPP1/PC-1) and Early Development of Advanced Diabetic Nephropathy in Type 1 Diabetes

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Topics: diabetes mellitus, type 1 , diabetic nephropathy , kidney failure, chronic , proteinuria , polymorphism

Diabetes April 2002, Vol.51, 1188-1193. doi:https://doi.org/10.2337/diabetes.51.4.1188

Altered Phosphodiesterase 3-Mediated cAMP Hydrolysis Contributes to a Hypermotile Phenotype in Obese JCR:LA-cp Rat Aortic Vascular Smooth Muscle Cells: Implications for Diabetes-Associated Cardiovascular Disease

Stuart J. Netherton; Sandra L. Jimmo; Daniel Palmer; Douglas G. Tilley; Heather A. Dunkerley; Daniel R. Raymond; James C. Russell; P. Marlene Absher; E. Helene Sage; Robert B. Vernon; Donald H. Maurice

Abstracts

View articletitled, Altered Phosphodiesterase 3-Mediated cAMP Hydrolysis Contributes to a Hypermotile Phenotype in Obese JCR:LA-cp Rat Aortic Vascular Smooth Muscle Cells: Implications for Diabetes-Associated Cardiovascular Disease

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Topics: aorta , cyclic amp , muscle, smooth, vascular , obesity , forskolin

Diabetes April 2002, Vol.51, 1194-1200. doi:https://doi.org/10.2337/diabetes.51.4.1194

ATP-Dependent K⁺ Channels Contribute to Local Metabolic Coronary Vasodilation in Experimental Diabetes

Johnathan D. Tune; Clement Yeh; Srinath Setty; H. Fred Downey

Abstracts

View articletitled, ATP-Dependent K+ Channels Contribute to Local Metabolic Coronary Vasodilation in Experimental Diabetes

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Topics: alloxan , coronary artery flow , diabetes mellitus, experimental , dog, domestic , glyburide

Diabetes April 2002, Vol.51, 1201-1207. doi:https://doi.org/10.2337/diabetes.51.4.1201

A Common Promoter Polymorphism in the Hepatic Lipase Gene (LIPC-480C>T) Is Associated With an Increase in Coronary Calcification in Type 1 Diabetes

John E. Hokanson; Suzanne Cheng; Janet K. Snell-Bergeon; Bonnie A. Fijal; Michael A. Grow; Chi Hung; Henry A. Erlich; James Ehrlich; Robert H. Eckel; Marian Rewers

Abstracts

View articletitled, A Common Promoter Polymorphism in the Hepatic Lipase Gene (LIPC-480C>T) Is Associated With an Increase in Coronary Calcification in Type 1 Diabetes

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Topics: alleles , coronary artery calcium , coronary heart disease , diabetes mellitus, type 1 , genes

Diabetes April 2002, Vol.51, 1208-1213. doi:https://doi.org/10.2337/diabetes.51.4.1208

Early Decrease of Skin Blood Flow in Response to Locally Applied Pressure in Diabetic Subjects

Berengere Fromy; Pierre Abraham; Celine Bouvet; Beatrice Bouhanick; Philippe Fressinaud; Jean Louis Saumet

Abstracts

View articletitled, Early Decrease of Skin Blood Flow in Response to Locally Applied Pressure in Diabetic Subjects

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Topics: neuropathy , skin , vascular flow , skin temperature

Diabetes April 2002, Vol.51, 1214-1217. doi:https://doi.org/10.2337/diabetes.51.4.1214

Difference in Ischemic Regulation of Vascular Endothelial Growth Factor and Pigment Epithelium--Derived Factor in Brown Norway and Sprague Dawley Rats Contributing to Different Susceptibilities to Retinal Neovascularization

Guoquan Gao; Yan Li; James Fant; Craig E. Crosson; S. Patricia Becerra; Jian-xing Ma

Abstracts

View articletitled, Difference in Ischemic Regulation of Vascular Endothelial Growth Factor and Pigment Epithelium--Derived Factor in Brown Norway and Sprague Dawley Rats Contributing to Different Susceptibilities to Retinal Neovascularization

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Topics: hyperoxia , ischemia , rats , retinal neovascularization , vascular endothelial growth factor a

Diabetes April 2002, Vol.51, 1218-1225. doi:https://doi.org/10.2337/diabetes.51.4.1218

Abnormalities of Glucose Metabolism in Patients With Early Renal Failure

Leonardo A. Sechi; Cristiana Catena; Laura Zingaro; Alessandra Melis; Sergio De Marchi

Abstracts

View articletitled, Abnormalities of Glucose Metabolism in Patients With Early Renal Failure

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Topics: creatinine clearance , glucose , glucose metabolism , hypertension , insulin

Diabetes April 2002, Vol.51, 1226-1232. doi:https://doi.org/10.2337/diabetes.51.4.1226

Hepatic Expression of Microsomal Triglyceride Transfer Protein and In Vivo Secretion of Triglyceride-Rich Lipoproteins Are Increased in Obese Diabetic Mice

Emil D. Bartels; Morten Lauritsen; Lars B. Nielsen

Abstracts

View articletitled, Hepatic Expression of Microsomal Triglyceride Transfer Protein and In Vivo Secretion of Triglyceride-Rich Lipoproteins Are Increased in Obese Diabetic Mice

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Topics: bodily secretions , lipoproteins , mice , obesity , rna, messenger

Diabetes April 2002, Vol.51, 1233-1239. doi:https://doi.org/10.2337/diabetes.51.4.1233

Genetics

The Second Activating Glucokinase Mutation (A456V): Implications for Glucose Homeostasis and Diabetes Therapy

Henrik B.T. Christesen; Bendt B. Jacobsen; Stella Odili; Carol Buettger; Antonio Cuesta-Munoz; Torben Hansen; Klaus Brusgaard; Ornella Massa; Mark A. Magnuson; Chiyo Shiota; Franz M. Matschinsky; Fabrizio Barbetti

Abstracts

View articletitled, The Second Activating Glucokinase Mutation (A456V): Implications for Glucose Homeostasis and Diabetes Therapy

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Topics: abcc8 gene , blood glucose , glucokinase , glucose , hypoglycemia

Diabetes April 2002, Vol.51, 1240-1246. doi:https://doi.org/10.2337/diabetes.51.4.1240

Genome-Wide Search for Type 2 Diabetes in Japanese Affected Sib-Pairs Confirms Susceptibility Genes on 3q, 15q, and 20q and Identifies Two New Candidate Loci on 7p and 11p

Yasumichi Mori; Shuichi Otabe; Christian Dina; Kazuki Yasuda; Céline Populaire; Cécile Lecoeur; Vincent Vatin; Emmanuelle Durand; Kazuo Hara; Terumasa Okada; Kazuyuki Tobe; Philippe Boutin; Takashi Kadowaki; Philippe Froguel

Abstracts

View articletitled, Genome-Wide Search for Type 2 Diabetes in Japanese Affected Sib-Pairs Confirms Susceptibility Genes on 3q, 15q, and 20q and Identifies Two New Candidate Loci on 7p and 11p

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Topics: diabetes mellitus, type 2 , genes , genome , body mass index procedure

Diabetes April 2002, Vol.51, 1247-1255. doi:https://doi.org/10.2337/diabetes.51.4.1247

Epidemiology

Type 2 Diabetes, APOE Gene, and the Risk for Dementia and Related Pathologies: The Honolulu-Asia Aging Study

Rita Peila; Beatriz L. Rodriguez; Lenore J. Launer

Abstracts

View articletitled, Type 2 Diabetes, APOE Gene, and the Risk for Dementia and Related Pathologies: The Honolulu-Asia Aging Study

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Topics: apolipoprotein e , dementia , ventricular septal defect , diabetes mellitus, type 2 , aging

Diabetes April 2002, Vol.51, 1256-1262. doi:https://doi.org/10.2337/diabetes.51.4.1256

Increased Proinsulin Levels and Decreased Acute Insulin Response Independently Predict the Incidence of Type 2 Diabetes in the Insulin Resistance Atherosclerosis Study

Anthony J.G. Hanley; Ralph D’Agostino, Jr.; Lynne E. Wagenknecht; Mohammed F. Saad; Peter J. Savage; Richard Bergman; Steven M. Haffner

Abstracts

View articletitled, Increased Proinsulin Levels and Decreased Acute Insulin Response Independently Predict the Incidence of Type 2 Diabetes in the Insulin Resistance Atherosclerosis Study

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Topics: diabetes mellitus, type 2 , insulin , insulin resistance , atherosclerosis , proinsulin

Diabetes April 2002, Vol.51, 1263-1270. doi:https://doi.org/10.2337/diabetes.51.4.1263

Early Differential Defects of Insulin Secretion and Action in 19-Year-Old Caucasian Men Who Had Low Birth Weight

Christine B. Jensen; Heidi Storgaard; Flemming Dela; Jens Juul Holst; Sten Madsbad; Allan A. Vaag

Abstracts

View articletitled, Early Differential Defects of Insulin Secretion and Action in 19-Year-Old Caucasian Men Who Had Low Birth Weight

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Topics: glucose , insulin , insulin secretion , oral glucose tolerance test , glycerol

Diabetes April 2002, Vol.51, 1271-1280. doi:https://doi.org/10.2337/diabetes.51.4.1271

Brief Genetics Reports

Peroxisome Proliferator-Activated Receptor-γ Coactivator-1 Gene Locus: Associations With Obesity Indices in Middle-Aged Women

Harald Esterbauer; Hannes Oberkofler; Veronika Linnemayr; Bernhard Iglseder; Margot Hedegger; Peter Wolfsgruber; Bernhard Paulweber; Gerd Fastner; Franz Krempler; Wolfgang Patsch

Abstracts

View articletitled, Peroxisome Proliferator-Activated Receptor-γ Coactivator-1 Gene Locus: Associations With Obesity Indices in Middle-Aged Women

Supplementary data

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Topics: genes , middle-aged adult , obesity , peroxisome-proliferator-activated receptor-gamma coactivator-1 , peroxisome

Diabetes April 2002, Vol.51, 1281-1286. doi:https://doi.org/10.2337/diabetes.51.4.1281

Association Studies of Genetic Variation in the WFS1 Gene and Type 2 Diabetes in U.K. Populations

Jayne A.L. Minton; Andrew T. Hattersley; Katharine Owen; Mark I. McCarthy; Mark Walker; Farida Latif; Timothy Barrett; Timothy M. Frayling

Abstracts

View articletitled, Association Studies of Genetic Variation in the WFS1 Gene and Type 2 Diabetes in U.K. Populations

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Topics: diabetes mellitus, type 2 , genes , alleles , haplotypes , polymerase chain reaction

Diabetes April 2002, Vol.51, 1287-1290. doi:https://doi.org/10.2337/diabetes.51.4.1287

Molecular Analysis of Berardinelli-Seip Congenital Lipodystrophy in Oman: Evidence for Multiple Loci

Kirsten Heathcote; Anna Rajab; Jocelyne Magré; Petros Syrris; Mehran Besti; Michael Patton; Marc Délépine; Mark Lathrop; Jacqueline Capeau; Steve Jeffery

Abstracts

View articletitled, Molecular Analysis of Berardinelli-Seip Congenital Lipodystrophy in Oman: Evidence for Multiple Loci

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Topics: familial generalized lipodystrophy , genes , homozygote , lipodystrophy , mutation

Diabetes April 2002, Vol.51, 1291-1293. doi:https://doi.org/10.2337/diabetes.51.4.1291

Erratum

Errata

Extract

View articletitled, Errata

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Topics: adiponectin , diabetes mellitus, type 2 , yoda project , christianity , genes

Diabetes April 2002, Vol.51, 1294. doi:https://doi.org/10.2337/diabetes.51.4.1294

Errata

Extract

View articletitled, Errata

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Topics: diabetes mellitus, type 1 , diabetic nephropathy , glomerular filtration rate , kidney , kidney glomerulus

Diabetes April 2002, Vol.51, 1294. doi:https://doi.org/10.2337/diabetes.51.4.1294-a

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