Skip Nav Destination
Issues
1 May 2002
ISSN 0012-1797
EISSN 1939-327X
Perspectives in Diabetes
The Ryanodine Receptor Calcium Channel of β-Cells: Molecular Regulation and Physiological Significance
Diabetes May 2002, Vol.51, 1299-1309. doi:https://doi.org/10.2337/diabetes.51.5.1299
Metabolism and Signal Transduction
Prevention of Overt Hypoglycemia During Exercise: Stimulation of Endogenous Glucose Production Independent of Hepatic Catecholamine Action and Changes in Pancreatic Hormone Concentration
Robert H. Coker; Yoshiharu Koyama; Joshua C. Denny; Raul C. Camacho; D. Brooks Lacy; David H. Wasserman
Diabetes May 2002, Vol.51, 1310-1318. doi:https://doi.org/10.2337/diabetes.51.5.1310
Obesity
Effects of Acute and Chronic Administration of the Melanocortin Agonist MTII in Mice With Diet-Induced Obesity
Dominique D. Pierroz; Mary Ziotopoulou; Linda Ungsunan; Stergios Moschos; Jeffrey S. Flier; Christos S. Mantzoros
Diabetes May 2002, Vol.51, 1337-1345. doi:https://doi.org/10.2337/diabetes.51.5.1337
Immunology
Genetic Effects on Age-Dependent Onset and Islet Cell Autoantibody Markers in Type 1 Diabetes
Jinko Graham; William A. Hagopian; Ingrid Kockum; Lou Sheng Li; Carani B. Sanjeevi; Robert M. Lowe; Jonathan B. Schaefer; Marjan Zarghami; Heather L. Day; Mona Landin-Olsson; Jerry P. Palmer; Marta Janer-Villanueva; Leroy Hood; Göran Sundkvist; Åke Lernmark; Norman Breslow; Gisela Dahlquist; for the Swedish Childhood Diabetes Study Group; Göran Blohmé; for the Diabetes Incidence in Sweden Study Group
Diabetes May 2002, Vol.51, 1346-1355. doi:https://doi.org/10.2337/diabetes.51.5.1346
Leptin Accelerates Autoimmune Diabetes in Female NOD Mice
Giuseppe Matarese; Veronica Sanna; Robert I. Lechler; Nora Sarvetnick; Silvia Fontana; Serafino Zappacosta; Antonio La Cava
Diabetes May 2002, Vol.51, 1356-1361. doi:https://doi.org/10.2337/diabetes.51.5.1356
Decreased Vascular Density in Mouse Pancreatic Islets After Transplantation
Diabetes May 2002, Vol.51, 1362-1366. doi:https://doi.org/10.2337/diabetes.51.5.1362
A 1α,25-Dihydroxyvitamin D3 Analog Enhances Regulatory T-Cells and Arrests Autoimmune Diabetes in NOD Mice
Diabetes May 2002, Vol.51, 1367-1374. doi:https://doi.org/10.2337/diabetes.51.5.1367
Detection of GAD65-Specific T-Cells by Major Histocompatibility Complex Class II Tetramers in Type 1 Diabetic Patients and At-Risk Subjects
Helena Reijonen; Erik J. Novak; Sharon Kochik; Anne Heninger; Andrew W. Liu; William W. Kwok; Gerald T. Nepom
Diabetes May 2002, Vol.51, 1375-1382. doi:https://doi.org/10.2337/diabetes.51.5.1375
Fas/Fas Ligand Interactions Play an Essential Role in the Initiation of Murine Autoimmune Diabetes
Maki Nakayama; Masao Nagata; Hisafumi Yasuda; Kenji Arisawa; Reiko Kotani; Katsumi Yamada; Shahead Ali Chowdhury; Sagarika Chakrabarty; Zhen Zi Jin; Hideo Yagita; Koichi Yokono; Masato Kasuga
Diabetes May 2002, Vol.51, 1391-1397. doi:https://doi.org/10.2337/diabetes.51.5.1391
Islet Studies
Combined Expression of Pancreatic Duodenal Homeobox 1 and Islet Factor 1 Induces Immature Enterocytes to Produce Insulin
Hideto Kojima; Takaaki Nakamura; Yukihiro Fujita; Akio Kishi; Mineko Fujimiya; Syu Yamada; Motoi Kudo; Yoshihiko Nishio; Hiroshi Maegawa; Masakazu Haneda; Hitoshi Yasuda; Itaru Kojima; Masaharu Seno; Norman C.W. Wong; Ryuichi Kikkawa; Atsunori Kashiwagi
Diabetes May 2002, Vol.51, 1398-1408. doi:https://doi.org/10.2337/diabetes.51.5.1398
Hepatocyte Nuclear Factor-1α Recruits the Transcriptional Co-Activator p300 on the GLUT2 Gene Promoter
Nobuhiro Ban; Yuichiro Yamada; Yoshimichi Someya; Kazumasa Miyawaki; Yu Ihara; Masaya Hosokawa; Shinya Toyokuni; Kinsuke Tsuda; Yutaka Seino
Diabetes May 2002, Vol.51, 1409-1418. doi:https://doi.org/10.2337/diabetes.51.5.1409
Modulation of L-Type Ca2+ Channels by Distinct Domains Within SNAP-25
Junzhi Ji; Shao-Nian Yang; Xiaohang Huang; Xidan Li; Laura Sheu; Nicholas Diamant; Per-Olof Berggren; Herbert Y. Gaisano
Diabetes May 2002, Vol.51, 1425-1436. doi:https://doi.org/10.2337/diabetes.51.5.1425
Prolonged Exposure to Free Fatty Acids Has Cytostatic and Pro-Apoptotic Effects on Human Pancreatic Islets: Evidence that β-Cell Death Is Caspase Mediated, Partially Dependent on Ceramide Pathway, and Bcl-2 Regulated
Roberto Lupi; Francesco Dotta; Lorella Marselli; Silvia Del Guerra; Matilde Masini; Carmela Santangelo; Giovanni Patané; Ugo Boggi; Salvatore Piro; Marcello Anello; Ettore Bergamini; Franco Mosca; Umberto Di Mario; Stefano Del Prato; Piero Marchetti
Diabetes May 2002, Vol.51, 1437-1442. doi:https://doi.org/10.2337/diabetes.51.5.1437
Persistent Improvement of Type 2 Diabetes in the Goto-Kakizaki Rat Model by Expansion of the β-Cell Mass During the Prediabetic Period With Glucagon-Like Peptide-1 or Exendin-4
Cécile Tourrel; Danielle Bailbe; Matthieu Lacorne; Marie-Jo Meile; Micheline Kergoat; Bernard Portha
Diabetes May 2002, Vol.51, 1443-1452. doi:https://doi.org/10.2337/diabetes.51.5.1443
A Potent and Highly Selective VPAC2 Agonist Enhances Glucose-Induced Insulin Release and Glucose Disposal: A Potential Therapy for Type 2 Diabetes
Manami Tsutsumi; Thomas H. Claus; Yin Liang; Yaxin Li; Ling Yang; Jian Zhu; Fernando Dela Cruz; Xianbu Peng; Hongxing Chen; Stephanie L. Yung; Sarah Hamren; James N. Livingston; Clark Q. Pan
Diabetes May 2002, Vol.51, 1453-1460. doi:https://doi.org/10.2337/diabetes.51.5.1453
Chronic Inhibition of Circulating Dipeptidyl Peptidase IV by FE 999011 Delays the Occurrence of Diabetes in Male Zucker Diabetic Fatty Rats
Béatrice Sudre; Pierre Broqua; Richard B. White; Doreen Ashworth; D. Michael Evans; Robert Haigh; Jean-Louis Junien; Michel L. Aubert
Diabetes May 2002, Vol.51, 1461-1469. doi:https://doi.org/10.2337/diabetes.51.5.1461
Brief Genetics Reports
Insulin Secretory Function Is Impaired in Isolated Human Islets Carrying the Gly972→Arg IRS-1 Polymorphism
Piero Marchetti; Roberto Lupi; Massimo Federici; Lorella Marselli; Matilde Masini; Ugo Boggi; Silvia Del Guerra; Giovanni Patanè; Salvatore Piro; Marcello Anello; Ettore Bergamini; Francesco Purrello; Renato Lauro; Franco Mosca; Giorgio Sesti; Stefano Del Prato
Diabetes May 2002, Vol.51, 1419-1424. doi:https://doi.org/10.2337/diabetes.51.5.1419
5′ Flanking Variants of Resistin Are Associated With Obesity
James C. Engert; Marie-Claude Vohl; Scott M. Williams; Pierre Lepage; J C. Loredo-Osti; Janet Faith; Carole Doré; Yannick Renaud; Noël P. Burtt; Amélie Villeneuve; Joel N. Hirschhorn; David Altshuler; Leif C. Groop; Jean-Pierre Després; Daniel Gaudet; Thomas J. Hudson
Diabetes May 2002, Vol.51, 1629-1634. doi:https://doi.org/10.2337/diabetes.51.5.1629
A Common Polymorphism in the 5′-Untranslated Region of the VEGF Gene Is Associated With Diabetic Retinopathy in Type 2 Diabetes
Takuya Awata; Kiyoaki Inoue; Susumu Kurihara; Tomoko Ohkubo; Masaki Watanabe; Kouichi Inukai; Ikuo Inoue; Shigehiro Katayama
Diabetes May 2002, Vol.51, 1635-1639. doi:https://doi.org/10.2337/diabetes.51.5.1635
Positional Candidate Gene Analysis of Lim Domain Homeobox Gene (Isl-1) on Chromosome 5q11-q13 in a French Morbidly Obese Population Suggests Indication for Association With Type 2 Diabetes
Mouna Barat-Houari; Karine Clément; Vincent Vatin; Christian Dina; Geneviève Bonhomme; Francis Vasseur; Bernard Guy-Grand; Philippe Froguel
Diabetes May 2002, Vol.51, 1640-1643. doi:https://doi.org/10.2337/diabetes.51.5.1640
Variation in Three Single Nucleotide Polymorphisms in the Calpain-10 Gene Not Associated With Type 2 Diabetes in a Large Finnish Cohort
Tasha E. Fingerlin; Michael R. Erdos; Richard M. Watanabe; Kerry R Wiles; Heather M. Stringham; Karen L. Mohlke; Kaisa Silander; Timo T. Valle; Thomas A. Buchanan; Jaakko Tuomilehto; Richard N. Bergman; Michael Boehnke; Francis S. Collins
Diabetes May 2002, Vol.51, 1644-1648. doi:https://doi.org/10.2337/diabetes.51.5.1644
IL12B Polymorphism and Type 1 Diabetes in the Italian Population: A Case-Control Study
Lorenza Nisticò; Gabriele Giorgi; Mara Giordano; Andrea Galgani; Antonio Petrone; Sandra D’Alfonso; Massimo Federici; Umberto Di Mario; Paolo Pozzilli; Raffaella Buzzetti; Isabella Cascino
Diabetes May 2002, Vol.51, 1649-1650. doi:https://doi.org/10.2337/diabetes.51.5.1649
Pathophysiology
Unexpected Sensitivity of Nonobese Diabetic Mice With a Disrupted Poly(ADP-Ribose) Polymerase-1 Gene to Streptozotocin-Induced and Spontaneous Diabetes
Cristina Gonzalez; Josiane Ménissier de Murcia; Philip Janiak; Jean-Pierre Bidouard; Catherine Beauvais; Saoussen Karray; Henri-Jean Garchon; Matthieu Lévi-Strauss
Diabetes May 2002, Vol.51, 1470-1476. doi:https://doi.org/10.2337/diabetes.51.5.1470
Limited Impact of Vigorous Exercise on Defenses Against Hypoglycemia: Relevance to Hypoglycemia-Associated Autonomic Failure
Diabetes May 2002, Vol.51, 1485-1492. doi:https://doi.org/10.2337/diabetes.51.5.1485
Insulin and Rosiglitazone Regulation of Lipolysis and Lipogenesis in Human Adipose Tissue In Vitro
Philip G. McTernan; Alison L. Harte; Leah A. Anderson; Allan Green; Stephen A. Smith; Julie C. Holder; Anthony H. Barnett; Margaret C. Eggo; Sudhesh Kumar
Diabetes May 2002, Vol.51, 1493-1498. doi:https://doi.org/10.2337/diabetes.51.5.1493
Gestational Diabetes Leads to the Development of Diabetes in Adulthood in the Rat
Diabetes May 2002, Vol.51, 1499-1506. doi:https://doi.org/10.2337/diabetes.51.5.1499
Rosiglitazone, a Peroxisome Proliferator-Activated Receptor-γ, Inhibits the Jun NH2-Terminal Kinase/Activating Protein 1 Pathway and Protects the Heart From Ischemia/Reperfusion Injury
Nassirah Khandoudi; Philippe Delerive; Isabelle Berrebi-Bertrand; Robin E. Buckingham; Bart Staels; Antoine Bril
Diabetes May 2002, Vol.51, 1507-1514. doi:https://doi.org/10.2337/diabetes.51.5.1507
Direct Evidence for Insulin-Induced Capillary Recruitment in Skin of Healthy Subjects During Physiological Hyperinsulinemia
Erik H. Serné; Richard G. IJzerman; Reinold O.B. Gans; Robin Nijveldt; Greetje de Vries; Reinder Evertz; Ab J.M. Donker; Coen D.A. Stehouwer
Diabetes May 2002, Vol.51, 1515-1522. doi:https://doi.org/10.2337/diabetes.51.5.1515
Complications
The 807T Allele in α2 Integrin Is Protective Against Atherosclerotic Arterial Wall Thickening and the Occurrence of Plaque in Patients With Type 2 Diabetes
Takaaki Maeno; Hidenori Koyama; Hideki Tahara; Miyoko Komatsu; Masanori Emoto; Tetsuo Shoji; Masaaki Inaba; Takami Miki; Yasuhisa Okuno; Yoshiki Nishizawa
Diabetes May 2002, Vol.51, 1523-1528. doi:https://doi.org/10.2337/diabetes.51.5.1523
The Genetics of Hypertension Modifies the Renal Cell Replication Response Induced by Experimental Diabetes
Diabetes May 2002, Vol.51, 1529-1534. doi:https://doi.org/10.2337/diabetes.51.5.1529
Advanced Glycation End Product Precursors Impair Epidermal Growth Factor Receptor Signaling
Manuel Portero-Otín; Reinald Pamplona; Maria Josep Bellmunt; Maria Cristina Ruiz; Joan Prat; Robert Salvayre; Anne Nègre-Salvayre
Diabetes May 2002, Vol.51, 1535-1542. doi:https://doi.org/10.2337/diabetes.51.5.1535
Associations of Insulin Levels With Left Ventricular Structure and Function in American Indians : The Strong Heart Study
Arzu Ilercil; Richard B. Devereux; Mary J. Roman; Mary Paranicas; Michael J. O’Grady; Elisa T. Lee; Thomas K. Welty; Richard R. Fabsitz; Barbara V. Howard
Diabetes May 2002, Vol.51, 1543-1547. doi:https://doi.org/10.2337/diabetes.51.5.1543
MEDICA 16 Inhibits Hepatic Acetyl-CoA Carboxylase and Reduces Plasma Triacylglycerol Levels in Insulin-Resistant JCR: LA-cp Rats
Diabetes May 2002, Vol.51, 1548-1555. doi:https://doi.org/10.2337/diabetes.51.5.1548
Mechanisms of Amelioration of Glucose-Induced Endothelial Dysfunction Following Inhibition of Protein Kinase C In Vivo
Diabetes May 2002, Vol.51, 1556-1564. doi:https://doi.org/10.2337/diabetes.51.5.1556
Downregulation of Connexin 43 Expression by High Glucose Reduces Gap Junction Activity in Microvascular Endothelial Cells
Diabetes May 2002, Vol.51, 1565-1571. doi:https://doi.org/10.2337/diabetes.51.5.1565
The Early Natural History of Nephropathy in Type 1 Diabetes: II. Early Renal Structural Changes in Type 1 Diabetes
Diabetes May 2002, Vol.51, 1580-1587. doi:https://doi.org/10.2337/diabetes.51.5.1580
Accumulation of 8-Hydroxy-2′-Deoxyguanosine and Mitochondrial DNA Deletion in Kidney of Diabetic Rats
Maiko Kakimoto; Toyoshi Inoguchi; Toshiyo Sonta; Hai Yan Yu; Minako Imamura; Takashi Etoh; Toshihiko Hashimoto; Hajime Nawata
Diabetes May 2002, Vol.51, 1588-1595. doi:https://doi.org/10.2337/diabetes.51.5.1588
C-Reactive Protein Is an Independent Predictor of Risk for the Development of Diabetes in the West of Scotland Coronary Prevention Study
Dilys J. Freeman; John Norrie; Muriel J. Caslake; Allan Gaw; Ian Ford; Gordon D.O. Lowe; Denis St. J. O’Reilly; Chris J. Packard; Naveed Sattar; for the West of Scotland Coronary Prevention Study Group
Diabetes May 2002, Vol.51, 1596-1600. doi:https://doi.org/10.2337/diabetes.51.5.1596
Genetics
Effect of the (C825T) Gβ3 Polymorphism on Adrenoceptor-Mediated Lipolysis in Human Fat Cells
Diabetes May 2002, Vol.51, 1601-1608. doi:https://doi.org/10.2337/diabetes.51.5.1601
Contribution of Known and Unknown Susceptibility Genes to Early-Onset Diabetes in Scandinavia: Evidence for Heterogeneity
Cecilia M. Lindgren; Elisabeth Widén; Tiinamaija Tuomi; Haiyan Li; Peter Almgren; Timo Kanninen; Olle Melander; Jianping Weng; Markku Lehto; Leif C. Groop
Diabetes May 2002, Vol.51, 1609-1617. doi:https://doi.org/10.2337/diabetes.51.5.1609
Polymorphisms in the Oxygen-Regulated Protein 150 Gene (ORP150) Are Associated With Insulin Resistance in Pima Indians
Diabetes May 2002, Vol.51, 1618-1621. doi:https://doi.org/10.2337/diabetes.51.5.1618
Haplotype Combinations of Calpain 10 Gene Polymorphisms Associate With Increased Risk of Impaired Glucose Tolerance and Type 2 Diabetes in South Indians
Paul G. Cassell; Alan E. Jackson; Bernard V. North; Julie C. Evans; Denise Syndercombe-Court; Chris Phillips; Ambady Ramachandran; Chamukuttan Snehalatha; Susan V. Gelding; Shanti Vijayaravaghan; David Curtis; Graham A. Hitman
Diabetes May 2002, Vol.51, 1622-1628. doi:https://doi.org/10.2337/diabetes.51.5.1622