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Issues
1 June 2002
ISSN 0012-1797
EISSN 1939-327X
Perspectives in Diabetes
Genetic Studies of Late Diabetic Complications: The Overlooked Importance of Diabetes Duration Before Complication Onset
Topics:
diabetes mellitus complications
,
proteinuria
,
genes
,
alleles
,
models, genetic
Diabetes June 2002, Vol.51, 1655-1662. doi:https://doi.org/10.2337/diabetes.51.6.1655
Metabolism
Direct and Indirect Effects of Insulin on Glucose Uptake and Storage by the Liver
Shosuke Satake; Mary Courtney Moore; Kayano Igawa; Margaret Converse; Benjamin Farmer; Doss W. Neal; Alan D. Cherrington
Topics:
glucose
,
infusion procedures
,
insulin
,
percutaneous ethanol injection therapy
,
liver
Diabetes June 2002, Vol.51, 1663-1671. doi:https://doi.org/10.2337/diabetes.51.6.1663
Role of the Insulin Receptor Substrate 1 and Phosphatidylinositol 3-Kinase Signaling Pathway in Insulin-Induced Expression of Sterol Regulatory Element Binding Protein 1c and Glucokinase Genes in Rat Hepatocytes
Michihiro Matsumoto; Wataru Ogawa; Kiyoshi Teshigawara; Hiroshi Inoue; Kazuaki Miyake; Hiroshi Sakaue; Masato Kasuga
Topics:
1-phosphatidylinositol 3-kinase
,
genes
,
hepatocytes
,
insulin
,
irs1 protein, human
Diabetes June 2002, Vol.51, 1672-1680. doi:https://doi.org/10.2337/diabetes.51.6.1672
Diabetes Impairs Hypothalamo-Pituitary-Adrenal (HPA) Responses to Hypoglycemia, and Insulin Treatment Normalizes HPA but not Epinephrine Responses
Topics:
hypoglycemia
,
insulin
,
rats
,
pituitary gland
,
epinephrine
Diabetes June 2002, Vol.51, 1681-1689. doi:https://doi.org/10.2337/diabetes.51.6.1681
Amino Acid Kinetics During the Anhepatic Phase of Liver Transplantation
Alberto Battezzati; Andrea Caumo; Annalisa Fattorini; Lucia Piceni Sereni; Jorgelina Coppa; Raffaele Romito; Mario Ammatuna; Enrico Regalia; Vincenzo Mazzaferro; Livio Luzi
Topics:
alanine
,
amino acids
,
glutamine
,
kinetics
,
leucine
Diabetes June 2002, Vol.51, 1690-1698. doi:https://doi.org/10.2337/diabetes.51.6.1690
Mature Adipocytes Inhibit In Vitro Differentiation of Human Preadipocytes via Angiotensin Type 1 Receptors
Topics:
adipocytes
,
angiotensin ii
,
coculture techniques
,
lipids
,
adipose tissue
Diabetes June 2002, Vol.51, 1699-1707. doi:https://doi.org/10.2337/diabetes.51.6.1699
Differential Effects of Fenofibrate or Simvastatin Treatment of Rats on Hepatic Microsomal Overt and Latent Diacylglycerol Acyltransferase Activities
Topics:
diet
,
fenofibrate
,
rats
,
simvastatin
,
transluminal attenuation gradient
Diabetes June 2002, Vol.51, 1708-1713. doi:https://doi.org/10.2337/diabetes.51.6.1708
A Nuclear Magnetic Resonance-Based Demonstration of Substantial Oxidative l-Alanine Metabolism and l-Alanine-Enhanced Glucose Metabolism in a Clonal Pancreatic β-Cell Line : Metabolism of l-Alanine Is Important to the Regulation of Insulin Secretion
Lorraine Brennan; Aine Shine; Chandralal Hewage; J. Paul G. Malthouse; Kevin M. Brindle; Neville McClenaghan; Peter R. Flatt; Philip Newsholme
Topics:
alanine
,
glucose
,
metabolism
,
glucose metabolism
,
insulin secretion
Diabetes June 2002, Vol.51, 1714-1721. doi:https://doi.org/10.2337/diabetes.51.6.1714
Sterol Regulatory Element Binding Protein-1c Expression and Action in Rat Muscles: Insulin-Like Effects on the Control of Glycolytic and Lipogenic Enzymes and UCP3 Gene Expression
Isabelle Guillet-Deniau; Virginie Mieulet; Soazig Le Lay; Younes Achouri; Denis Carré; Jean Girard; Fabienne Foufelle; Pascal Ferré
Topics:
insulin
,
genes
,
gene expression
,
enzymes
,
adenoviruses
Diabetes June 2002, Vol.51, 1722-1728. doi:https://doi.org/10.2337/diabetes.51.6.1722
Obesity
Central Leptin Gene Therapy Blocks High-Fat Diet-Induced Weight Gain, Hyperleptinemia, and Hyperinsulinemia : Increase in Serum Ghrelin Levels
Topics:
diet
,
ghrelin
,
leptin
,
rats
,
rna, messenger
Diabetes June 2002, Vol.51, 1729-1736. doi:https://doi.org/10.2337/diabetes.51.6.1729
Humoral Regulation of Resistin Expression in 3T3-L1 and Mouse Adipose Cells
Nobuhiro Shojima; Hideyuki Sakoda; Takehide Ogihara; Midori Fujishiro; Hideki Katagiri; Motonobu Anai; Yukiko Onishi; Hiraku Ono; Kouichi Inukai; Miho Abe; Yasushi Fukushima; Masatoshi Kikuchi; Yoshitomo Oka; Tomoichiro Asano
Topics:
resistin
,
tumor necrosis factors
,
adipocytes
,
dexamethasone
,
mice
Diabetes June 2002, Vol.51, 1737-1744. doi:https://doi.org/10.2337/diabetes.51.6.1737
Immunology
Characterization of the T-Cell Response to Coxsackievirus B4: Evidence That Effector Memory Cells Predominate in Patients With Type 1 Diabetes
Topics:
antigens
,
cytokine
,
diabetes mellitus, type 1
,
t-lymphocytes
,
coxsackie viruses
Diabetes June 2002, Vol.51, 1745-1753. doi:https://doi.org/10.2337/diabetes.51.6.1745
A 12-Year Prospective Study of the Relationship Between Islet Antibodies and β-Cell Function At and After the Diagnosis in Patients With Adult-Onset Diabetes
Topics:
antibodies
Diabetes June 2002, Vol.51, 1754-1762. doi:https://doi.org/10.2337/diabetes.51.6.1754
Islet
Expression of the Vesicular Inhibitory Amino Acid Transporter in Pancreatic Islet Cells : Distribution of the Transporter Within Rat Islets
Topics:
antibodies
,
gamma-aminobutyric acid
,
immunohistochemistry
,
endocrine pancreas
,
membrane transport proteins
Diabetes June 2002, Vol.51, 1763-1771. doi:https://doi.org/10.2337/diabetes.51.6.1763
Inhibition of Interleukin-1β-Induced COX-2 and EP3 Gene Expression by Sodium Salicylate Enhances Pancreatic Islet β-Cell Function
Topics:
cyclooxygenase-2
,
endocrine pancreas
,
gene expression
,
glucose
,
insulin secretion
Diabetes June 2002, Vol.51, 1772-1778. doi:https://doi.org/10.2337/diabetes.51.6.1772
Inhibition of Thrombin Abrogates the Instant Blood-Mediated Inflammatory Reaction Triggered by Isolated Human Islets: Possible Application of the Thrombin Inhibitor Melagatran in Clinical Islet Transplantation
Topics:
melagatran
,
tubing
,
perfusion
,
thrombin
,
islets of langerhans transplantation
Diabetes June 2002, Vol.51, 1779-1784. doi:https://doi.org/10.2337/diabetes.51.6.1779
Hepatocyte Nuclear Factor-1α Modulates Pancreatic β-Cell Growth by Regulating the Expression of Insulin-Like Growth Factor-1 in INS-1 Cells
Qin Yang; Kazuya Yamagata; Kenji Fukui; Yang Cao; Takao Nammo; Hiromi Iwahashi; Haiyan Wang; Itaru Matsumura; Toshiaki Hanafusa; Richard Bucala; Claes B. Wollheim; Jun-ichiro Miyagawa; Yuji Matsuzawa
Topics:
cell growth
,
doxycycline
,
insulin-like growth factor i
,
thymidine
,
pancreas
Diabetes June 2002, Vol.51, 1785-1792. doi:https://doi.org/10.2337/diabetes.51.6.1785
Overexpression of c-Myc in β-Cells of Transgenic Mice Causes Proliferation and Apoptosis, Downregulation of Insulin Gene Expression, and Diabetes
D. Ross Laybutt; Gordon C. Weir; Hideaki Kaneto; Judith Lebet; Richard D. Palmiter; Arun Sharma; Susan Bonner-Weir
Topics:
c-myc genes
,
insulin
,
mice, transgenic
,
pancreas
,
gene expression
Diabetes June 2002, Vol.51, 1793-1804. doi:https://doi.org/10.2337/diabetes.51.6.1793
cFLIP Protein Prevents Tumor Necrosis Factor-α–Mediated Induction of Caspase-8–Dependent Apoptosis in Insulin-Secreting βTc-Tet Cells
Topics:
apoptosis
,
caspase-8
,
cytokine
,
insulin
,
tumor necrosis factors
Diabetes June 2002, Vol.51, 1805-1814. doi:https://doi.org/10.2337/diabetes.51.6.1805
Na/Ca Exchanger Overexpression Induces Endoplasmic Reticulum–Related Apoptosis and Caspase-12 Activation in Insulin-Releasing BRIN-BD11 Cells
Topics:
apoptosis
,
caspases
,
emergency service, hospital
,
insulin
,
ionomycin
Diabetes June 2002, Vol.51, 1815-1824. doi:https://doi.org/10.2337/diabetes.51.6.1815
The Composition of Dietary Fat Directly Influences Glucose-Stimulated Insulin Secretion in Rats
Robert L. Dobbins; Lidia S. Szczepaniak; Jeff Myhill; Yoshifumi Tamura; Hiroshi Uchino; Adria Giacca; J. Denis McGarry
Topics:
diet
,
fatty acids
,
glucose
,
hyperglycemic agents
,
infusion procedures
Diabetes June 2002, Vol.51, 1825-1833. doi:https://doi.org/10.2337/diabetes.51.6.1825
β-Cell Neogenesis During Prolonged Hyperglycemia in Rats
Topics:
glucose
,
infusion procedures
,
rats
,
saline solutions
,
hyperglycemia
Diabetes June 2002, Vol.51, 1834-1841. doi:https://doi.org/10.2337/diabetes.51.6.1834
Targeted Disruption of the Protein Tyrosine Phosphatase-Like Molecule IA-2 Results in Alterations in Glucose Tolerance Tests and Insulin Secretion
Topics:
glucose
,
glucose tolerance test
,
insulin
,
insulin secretion
,
mice
Diabetes June 2002, Vol.51, 1842-1850. doi:https://doi.org/10.2337/diabetes.51.6.1842
Pathophysiology
Antidiabetic Effects of Panax ginseng Berry Extract and the Identification of an Effective Component
Anoja S. Attele; Yun-Ping Zhou; Jing-Tian Xie; Ji An Wu; Liu Zhang; Lucy Dey; William Pugh; Paul A. Rue; Kenneth S. Polonsky; Chun-Su Yuan
Topics:
mice
,
panax
,
insulin
,
glucose
,
antidiabetics
Diabetes June 2002, Vol.51, 1851-1858. doi:https://doi.org/10.2337/diabetes.51.6.1851
Tanis: A Link Between Type 2 Diabetes and Inflammation?
Ken Walder; Lakshmi Kantham; Janine S. McMillan; James Trevaskis; Lyndal Kerr; Andrea de Silva; Terry Sunderland; Nathan Godde; Yuan Gao; Natalie Bishara; Kelly Windmill; Janette Tenne-Brown; Guy Augert; Paul Z. Zimmet; Greg R. Collier
Topics:
diabetes mellitus, type 2
,
differential display technique
,
gene expression
,
genes
,
glucose
Diabetes June 2002, Vol.51, 1859-1866. doi:https://doi.org/10.2337/diabetes.51.6.1859
Sensitivity to Acute Insulin-Mediated Suppression of Plasma Free Fatty Acids Is Not a Determinant of Fasting VLDL Triglyceride Secretion in Healthy Humans
Topics:
fasting
,
insulin
,
lipoproteins, vldl
,
plasma
,
c-peptide
Diabetes June 2002, Vol.51, 1867-1875. doi:https://doi.org/10.2337/diabetes.51.6.1867
Altered Tumor Necrosis Factor-α (TNF-α) Processing in Adipocytes and Increased Expression of Transmembrane TNF-α in Obesity
Topics:
adipocytes
,
obesity
,
transarterial chemoembolization
,
tumor necrosis factors
,
adipose tissue
Diabetes June 2002, Vol.51, 1876-1883. doi:https://doi.org/10.2337/diabetes.51.6.1876
Plasma Adiponectin Concentration Is Associated With Skeletal Muscle Insulin Receptor Tyrosine Phosphorylation, and Low Plasma Concentration Precedes a Decrease in Whole-Body Insulin Sensitivity in Humans
Norbert Stefan; Barbora Vozarova; Tohru Funahashi; Yuji Matsuzawa; Christian Weyer; Robert S. Lindsay; Jack F. Youngren; Peter J. Havel; Richard E. Pratley; Clifton Bogardus; P. Antonio Tataranni
Topics:
adiponectin
,
glucose
,
insulin
,
insulin sensitivity
,
phosphorylation
Diabetes June 2002, Vol.51, 1884-1888. doi:https://doi.org/10.2337/diabetes.51.6.1884
High Alanine Aminotransferase Is Associated With Decreased Hepatic Insulin Sensitivity and Predicts the Development of Type 2 Diabetes
Barbora Vozarova; Norbert Stefan; Robert S. Lindsay; Aramesh Saremi; Richard E. Pratley; Clifton Bogardus; P. Antonio Tataranni
Topics:
alanine transaminase
,
diabetes mellitus, type 2
,
insulin
,
insulin sensitivity
,
liver enzyme
Diabetes June 2002, Vol.51, 1889-1895. doi:https://doi.org/10.2337/diabetes.51.6.1889
The Novel Diazoxide Analog 3-Isopropylamino-7-Methoxy-4H-1,2,4-Benzothiadiazine 1,1-Dioxide Is a Selective Kir6.2/SUR1 Channel Opener
Michael Dabrowski; Frances M. Ashcroft; Rebecca Ashfield; Philippe Lebrun; Bernard Pirotte; Jan Egebjerg; John Bondo Hansen; Philip Wahl
Topics:
abcc8 gene
,
diazoxide
,
glyburide
,
nucleotides
,
benzothiadiazines
Diabetes June 2002, Vol.51, 1896-1906. doi:https://doi.org/10.2337/diabetes.51.6.1896
Female Rats Do Not Exhibit Free Fatty Acid–Induced Insulin Resistance
Topics:
1-phosphatidylinositol 3-kinase
,
cd36 antigens
,
glucose
,
infusion procedures
,
insulin
Diabetes June 2002, Vol.51, 1907-1912. doi:https://doi.org/10.2337/diabetes.51.6.1907
Gene Expression Profile in Skeletal Muscle of Type 2 Diabetes and the Effect of Insulin Treatment
Topics:
diabetes mellitus, type 2
,
genes
,
insulin
,
skeletal muscles
,
gene expression profiling
Diabetes June 2002, Vol.51, 1913-1920. doi:https://doi.org/10.2337/diabetes.51.6.1913
Differential Effects of Tumor Necrosis Factor-α on Protein Kinase C Isoforms α and δ Mediate Inhibition of Insulin Receptor Signaling
Topics:
insulin
,
irs1 protein, human
,
protein isoforms
,
signal transduction
,
tumor necrosis factors
Diabetes June 2002, Vol.51, 1921-1930. doi:https://doi.org/10.2337/diabetes.51.6.1921
Complications
Interleukin-10 Protects Nitric Oxide–Dependent Relaxation During Diabetes: Role of Superoxide
Topics:
interleukin-10
,
mice
,
superoxides
,
xanthine oxidase
,
acetylcholine
Diabetes June 2002, Vol.51, 1931-1937. doi:https://doi.org/10.2337/diabetes.51.6.1931
Hyperglycemia-Induced Apoptosis in Mouse Myocardium: Mitochondrial Cytochrome c–Mediated Caspase-3 Activation Pathway
Topics:
apoptosis
,
caspase-3
,
cytochrome c
,
glucose
,
heart
Diabetes June 2002, Vol.51, 1938-1948. doi:https://doi.org/10.2337/diabetes.51.6.1938
Lipoprotein Subclasses and Particle Sizes and Their Relationship With Coronary Artery Calcification in Men and Women With and Without Type 1 Diabetes
Helen M. Colhoun; James D. Otvos; Mike B. Rubens; M. R. Taskinen; S. Richard Underwood; John H. Fuller
Topics:
coronary artery calcium
,
high density lipoproteins
,
lipoproteins
,
lipoproteins, vldl
,
low-density lipoproteins
Diabetes June 2002, Vol.51, 1949-1956. doi:https://doi.org/10.2337/diabetes.51.6.1949
Thrombomodulin Deficiency in Human Diabetic Nerve Microvasculature
Topics:
diabetic neuropathies
,
fibrinolytic agents
,
microvascular network
,
microvessels
,
neurons
Diabetes June 2002, Vol.51, 1957-1963. doi:https://doi.org/10.2337/diabetes.51.6.1957
Genetics
Enterovirus RNA Is Found in Peripheral Blood Mononuclear Cells in a Majority of Type 1 Diabetic Children at Onset
Topics:
antibodies
,
child
,
diabetes mellitus, type 1
,
polymerase chain reaction
,
rna
Diabetes June 2002, Vol.51, 1964-1971. doi:https://doi.org/10.2337/diabetes.51.6.1964
The Diabetes-Prone BB Rat Carries a Frameshift Mutation in Ian4, a Positional Candidate of Iddm1
Topics:
chromosome mapping
,
diabetes mellitus, type 1
,
frameshift mutation function
,
genes
,
rats, inbred bb
Diabetes June 2002, Vol.51, 1972-1979. doi:https://doi.org/10.2337/diabetes.51.6.1972
Mutations in the Human Leptin and Leptin Receptor Genes as Models of Serum Leptin Receptor Regulation
Topics:
leptin
,
serum leptin measurement
,
obesity
,
genes
Diabetes June 2002, Vol.51, 1980-1985. doi:https://doi.org/10.2337/diabetes.51.6.1980
Brief Genetics Report
Insertion/Deletion Polymorphism of the ACE Gene Is Associated With Type 2 Diabetes
Topics:
ace gene
,
angiotensin-converting enzyme inhibitors
,
diabetes mellitus, type 2
,
polymorphism
,
dna
Diabetes June 2002, Vol.51, 1986-1988. doi:https://doi.org/10.2337/diabetes.51.6.1986
An X-Chromosome Scan Reveals a Locus for Fat Distribution in Chromosome Region Xp21–22
Topics:
body fat distribution
,
body mass index procedure
,
chromosomes
,
obesity
,
phenotype
Diabetes June 2002, Vol.51, 1989-1991. doi:https://doi.org/10.2337/diabetes.51.6.1989
Erratum
Erratum
Topics:
anesthesia-related cardiac arrest
,
diabetes mellitus, type 2
,
genes
,
mutation analysis
,
obesity
Diabetes June 2002, Vol.51, 1992. doi:https://doi.org/10.2337/diabetes.51.6.1992
