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Issues
1 July 2002
ISSN 0012-1797
EISSN 1939-327X
Rapid Publication
Functional Genomics of the Endocrine Pancreas: The Pancreas Clone Set and PancChip, New Resources for Diabetes Research
L. Marie Scearce; John E. Brestelli; Shannon K. McWeeney; Catherine S. Lee; Joan Mazzarelli; Deborah F. Pinney; Angel Pizarro; Christian J. Stoeckert, Jr.; Sandra W. Clifton; M. Alan Permutt; Juliana Brown; Douglas A. Melton; Klaus H. Kaestner
Diabetes July 2002, Vol.51, 1997-2004. doi:https://doi.org/10.2337/diabetes.51.7.1997
Lipid-Induced Insulin Resistance in Human Muscle Is Associated With Changes in Diacylglycerol, Protein Kinase C, and IκB-α
Diabetes July 2002, Vol.51, 2005-2011. doi:https://doi.org/10.2337/diabetes.51.7.2005
The Gene INPPL1, Encoding the Lipid Phosphatase SHIP2, Is a Candidate for Type 2 Diabetes In Rat and Man
Evelyne Marion; Pamela Jane Kaisaki; Valérie Pouillon; Cyril Gueydan; Jonathan C. Levy; André Bodson; Georges Krzentowski; Jean-Claude Daubresse; Jean Mockel; Jens Behrends; Geneviève Servais; Claude Szpirer; Véronique Kruys; Dominique Gauguier; Stéphane Schurmans
Diabetes July 2002, Vol.51, 2012-2017. doi:https://doi.org/10.2337/diabetes.51.7.2012
Critical Role for Cataplerosis via Citrate in Glucose-Regulated Insulin Release
Diabetes July 2002, Vol.51, 2018-2024. doi:https://doi.org/10.2337/diabetes.51.7.2018
Perspectives in Diabetes
Metabolism and Signal Transduction
Increased Lipolysis and Decreased Leptin Production by Human Omental as Compared With Subcutaneous Preadipocytes
Vanessa van Harmelen; Andrea Dicker; Mikael Rydén; Hans Hauner; Fredrik Lönnqvist; Erik Näslund; Peter Arner
Diabetes July 2002, Vol.51, 2029-2036. doi:https://doi.org/10.2337/diabetes.51.7.2029
Isomer-Dependent Metabolic Effects of Conjugated Linoleic Acid: Insights From Molecular Markers Sterol Regulatory Element-Binding Protein-1c and LXRα
Helen M. Roche; Enda Noone; Ciaran Sewter; Siobhan Mc Bennett; David Savage; Michael J. Gibney; Stephen O’Rahilly; Antonio J. Vidal-Puig
Diabetes July 2002, Vol.51, 2037-2044. doi:https://doi.org/10.2337/diabetes.51.7.2037
Role of Peroxisome Proliferator-Activated Receptor-γ in Maintenance of the Characteristics of Mature 3T3-L1 Adipocytes
Diabetes July 2002, Vol.51, 2045-2055. doi:https://doi.org/10.2337/diabetes.51.7.2045
Glucokinase Is the Likely Mediator of Glucosensing in Both Glucose-Excited and Glucose-Inhibited Central Neurons
Diabetes July 2002, Vol.51, 2056-2065. doi:https://doi.org/10.2337/diabetes.51.7.2056
Normalization of Skeletal Muscle Glycogen Synthesis and Glycolysis in Rosiglitazone-Treated Zucker Fatty Rats: An In Vivo Nuclear Magnetic Resonance Study
Beat M. Jucker; Thomas R. Schaeffer; Robin E. Haimbach; Thomas S. McIntosh; Daniel Chun; Matthew Mayer; Derek H. Ohlstein; Hugh M. Davis; Stephen A. Smith; Alexander R. Cobitz; Susanta K. Sarkar
Diabetes July 2002, Vol.51, 2066-2073. doi:https://doi.org/10.2337/diabetes.51.7.2066
Metformin Increases AMP-Activated Protein Kinase Activity in Skeletal Muscle of Subjects With Type 2 Diabetes
Nicolas Musi; Michael F. Hirshman; Jonas Nygren; Monika Svanfeldt; Peter Bavenholm; Olav Rooyackers; Gaochao Zhou; Joanne M. Williamson; Olle Ljunqvist; Suad Efendic; David E. Moller; Anders Thorell; Laurie J. Goodyear
Diabetes July 2002, Vol.51, 2074-2081. doi:https://doi.org/10.2337/diabetes.51.7.2074
Improved Insulin Sensitivity Is Associated With Restricted Intake of Dietary Glycoxidation Products in the db/db Mouse
Susanna M. Hofmann; Heng-Jiang Dong; Zhu Li; Weijing Cai; Jennifer Altomonte; Swan N. Thung; Feng Zeng; Edward A. Fisher; Helen Vlassara
Diabetes July 2002, Vol.51, 2082-2089. doi:https://doi.org/10.2337/diabetes.51.7.2082
Obesity Studies
Appetite Suppression and Weight Reduction by a Centrally Active Aminosterol
Rexford S. Ahima; Hiralben R. Patel; Nobuhiko Takahashi; Yong Qi; Stanley M. Hileman; Michael A. Zasloff
Diabetes July 2002, Vol.51, 2099-2104. doi:https://doi.org/10.2337/diabetes.51.7.2099
Regulation of Circulating Soluble Leptin Receptor Levels By Gender, Adiposity, Sex Steroids, and Leptin : Observational and Interventional Studies in Humans
Jean L. Chan; Susann Blüher; Nikos Yiannakouris; Marc A. Suchard; Jurgen Kratzsch; Christos S. Mantzoros
Diabetes July 2002, Vol.51, 2105-2112. doi:https://doi.org/10.2337/diabetes.51.7.2105
Adrenalectomy Improves Diabetes in A-ZIP/F-1 Lipoatrophic Mice by Increasing Both Liver and Muscle Insulin Sensitivity
Martin Haluzik; Kelly R. Dietz; Jason K. Kim; Bernice Marcus-Samuels; Gerald I. Shulman; Oksana Gavrilova; Marc L. Reitman
Diabetes July 2002, Vol.51, 2113-2118. doi:https://doi.org/10.2337/diabetes.51.7.2113
Immunology and Transplantation
Redirection of Human Autoreactive T-Cells Upon Interaction With Dendritic Cells Modulated by TX527, an Analog of 1,25 Dihydroxyvitamin D3
Astrid G.S. van Halteren; Evelyne van Etten; Esther C. de Jong; Roger Bouillon; Bart O. Roep; Chantal Mathieu
Diabetes July 2002, Vol.51, 2119-2125. doi:https://doi.org/10.2337/diabetes.51.7.2119
Immunological Characterization and Therapeutic Activity of an Altered-Peptide Ligand, NBI-6024, Based on the Immunodominant Type 1 Diabetes Autoantigen Insulin B-Chain (9–23) Peptide
David G. Alleva; Amitabh Gaur; Liping Jin; Dale Wegmann; Peter A. Gottlieb; Anil Pahuja; Eric B. Johnson; Theresa Motheral; Amy Putnam; Paul D. Crowe; Nicholas Ling; Stefen A. Boehme; Paul J. Conlon
Diabetes July 2002, Vol.51, 2126-2134. doi:https://doi.org/10.2337/diabetes.51.7.2126
Pancreatic Islet Transplantation Using the Nonhuman Primate (Rhesus) Model Predicts That the Portal Vein Is Superior to the Celiac Artery as the Islet Infusion Site
Boaz Hirshberg; Sean Montgomery; Michael G. Wysoki; He Xu; Doug Tadaki; Janet Lee; Kenneth Hines; Jason Gaglia; Noelle Patterson; John Leconte; Douglas Hale; Richard Chang; Alan D. Kirk; David M. Harlan
Diabetes July 2002, Vol.51, 2135-2140. doi:https://doi.org/10.2337/diabetes.51.7.2135
Islet Studies
Successful Islet Transplantation: Continued Insulin Reserve Provides Long-Term Glycemic Control
Edmond A. Ryan; Jonathan R.T. Lakey; Breay W. Paty; Sharleen Imes; Gregory S. Korbutt; Norman M. Kneteman; David Bigam; Ray V. Rajotte; A.M. James Shapiro
Diabetes July 2002, Vol.51, 2148-2157. doi:https://doi.org/10.2337/diabetes.51.7.2148
Estrogen Can Prevent or Reverse Obesity and Diabetes in Mice Expressing Human Islet Amyloid Polypeptide
John G. Geisler; Walter Zawalich; Kathleen Zawalich; Jonathan R.T. Lakey; Hans Stukenbrok; Anthony J. Milici; Walter C. Soeller
Diabetes July 2002, Vol.51, 2158-2169. doi:https://doi.org/10.2337/diabetes.51.7.2158
Pathophysiology
β-Cell Function Is a Major Contributor to Oral Glucose Tolerance in High-Risk Relatives of Four Ethnic Groups in the U.S.
Christine C. Jensen; Miriam Cnop; Rebecca L. Hull; Wilfred Y. Fujimoto; Steven E. Kahn; the American Diabetes Association GENNID Study Group
Diabetes July 2002, Vol.51, 2170-2178. doi:https://doi.org/10.2337/diabetes.51.7.2170
Glycemic Control Determines Hepatic and Peripheral Glucose Effectiveness in Type 2 Diabetic Subjects
Diabetes July 2002, Vol.51, 2179-2189. doi:https://doi.org/10.2337/diabetes.51.7.2179
Inhibition of Glycogen Synthase Kinase 3 Improves Insulin Action and Glucose Metabolism in Human Skeletal Muscle
Svetlana E. Nikoulina; Theodore P. Ciaraldi; Sunder Mudaliar; Leslie Carter; Kirk Johnson; Robert R. Henry
Diabetes July 2002, Vol.51, 2190-2198. doi:https://doi.org/10.2337/diabetes.51.7.2190
Long-Term AICAR Administration Reduces Metabolic Disturbances and Lowers Blood Pressure in Rats Displaying Features of the Insulin Resistance Syndrome
Esben S. Buhl; Niels Jessen; Rasmus Pold; Thomas Ledet; Allan Flyvbjerg; Steen B. Pedersen; Oluf Pedersen; Ole Schmitz; Sten Lund
Diabetes July 2002, Vol.51, 2199-2206. doi:https://doi.org/10.2337/diabetes.51.7.2199
TNF-α Is a Predictor of Insulin Resistance in Human Pregnancy
John P. Kirwan; Sylvie Hauguel-De Mouzon; Jacques Lepercq; Jean-Claude Challier; Larraine Huston-Presley; Jacob E. Friedman; Satish C. Kalhan; Patrick M. Catalano
Diabetes July 2002, Vol.51, 2207-2213. doi:https://doi.org/10.2337/diabetes.51.7.2207
Alterations in the Activity of Placental Amino Acid Transporters in Pregnancies Complicated by Diabetes
Diabetes July 2002, Vol.51, 2214-2219. doi:https://doi.org/10.2337/diabetes.51.7.2214
The Effect of a 3-Month Low-Intensity Endurance Training Program on Fat Oxidation and Acetyl-CoA Carboxylase-2 Expression
Patrick Schrauwen; Dorien P.C. van Aggel-Leijssen; Gabby Hul; Anton J.M. Wagenmakers; Hubert Vidal; Wim H.M. Saris; Marleen A. van Baak
Diabetes July 2002, Vol.51, 2220-2226. doi:https://doi.org/10.2337/diabetes.51.7.2220
Complications
Influence of Experimental Diabetes on the Microcirculation of Injured Peripheral Nerve: Functional and Morphological Aspects
Diabetes July 2002, Vol.51, 2233-2240. doi:https://doi.org/10.2337/diabetes.51.7.2233
Activation of Nuclear Factor-κB Induced by Diabetes and High Glucose Regulates a Proapoptotic Program in Retinal Pericytes
Diabetes July 2002, Vol.51, 2241-2248. doi:https://doi.org/10.2337/diabetes.51.7.2241
Elevated Spinal Cyclooxygenase and Prostaglandin Release During Hyperalgesia in Diabetic Rats
Diabetes July 2002, Vol.51, 2249-2255. doi:https://doi.org/10.2337/diabetes.51.7.2249
Modulation of Growth Hormone Signal Transduction in Kidneys of Streptozotocin-Induced Diabetic Animals: Effect of a Growth Hormone Receptor Antagonist
Ana C.P. Thirone; John A. Scarlett; Alessandra L. Gasparetti; Eliana P. Araujo; Maria H.L. Lima; Carla R.O. Carvalho; Lício A. Velloso; Mario J.A. Saad
Diabetes July 2002, Vol.51, 2270-2281. doi:https://doi.org/10.2337/diabetes.51.7.2270
Endothelial Dysfunction Relates to Folate Status in Children and Adolescents With Type 1 Diabetes
Diabetes July 2002, Vol.51, 2282-2286. doi:https://doi.org/10.2337/diabetes.51.7.2282
Epidemiology
Vitamin D Receptor (VDR) mRNA and VDR Protein Levels in Relation to Vitamin D Status, Insulin Secretory Capacity, and VDR Genotype in Bangladeshi Asians
Babatunji-William Ogunkolade; Barbara J. Boucher; Jean M. Prahl; Stephen A. Bustin; Jacky M. Burrin; Kate Noonan; Bernard V. North; Nassima Mannan; Michael F. McDermott; Hector F. DeLuca; Graham A. Hitman
Diabetes July 2002, Vol.51, 2294-2300. doi:https://doi.org/10.2337/diabetes.51.7.2294
Genetics
Loss of Kinase Activity in a Patient With Wolcott-Rallison Syndrome Caused By a Novel Mutation in the EIF2AK3 Gene
Diabetes July 2002, Vol.51, 2301-2305. doi:https://doi.org/10.2337/diabetes.51.7.2301
A Haplotype at the Adiponectin Locus Is Associated With Obesity and Other Features of the Insulin Resistance Syndrome
Claudia Menzaghi; Tonino Ercolino; Rosa Di Paola; Anders H. Berg; James H. Warram; Philipp E. Scherer; Vincenzo Trischitta; Alessandro Doria
Diabetes July 2002, Vol.51, 2306-2312. doi:https://doi.org/10.2337/diabetes.51.7.2306
Brief Genetics Report
A Putative Functional Polymorphism in the IGF-I Gene: Association Studies With Type 2 Diabetes, Adult Height, Glucose Tolerance, and Fetal Growth in U.K. Populations
Timothy M. Frayling; Andrew T. Hattersley; Anne McCarthy; Jeff Holly; Simon M.S. Mitchell; Anna L. Gloyn; Katharine Owen; David Davies; George Davey Smith; Yoav Ben-Shlomo
Diabetes July 2002, Vol.51, 2313-2316. doi:https://doi.org/10.2337/diabetes.51.7.2313
Defining the Importance of Mitochondrial Gene Defects in Maternally Inherited Diabetes by Sequencing the Entire Mitochondrial Genome
Alan T.W. Choo-Kang; Stephen Lynn; Geoffrey A. Taylor; Mark E. Daly; Sarbpreet S. Sihota; Teressa M. Wardell; Patrick F. Chinnery; Douglass M. Turnbull; Mark Walker
Diabetes July 2002, Vol.51, 2317-2320. doi:https://doi.org/10.2337/diabetes.51.7.2317
The Effects of the Pro12Ala Polymorphism of the Peroxisome Proliferator-Activated Receptor-γ2 Gene on Insulin Sensitivity and Insulin Metabolism Interact With Size at Birth
Johan G. Eriksson; Virpi Lindi; Matti Uusitupa; Tom J. Forsén; Markku Laakso; Clive Osmond; David J.P. Barker
Diabetes July 2002, Vol.51, 2321-2324. doi:https://doi.org/10.2337/diabetes.51.7.2321
Association of Adiponectin Mutation With Type 2 Diabetes : A Candidate Gene for the Insulin Resistance Syndrome
Hidehiko Kondo; Iichiro Shimomura; Yuko Matsukawa; Masahiro Kumada; Masahiko Takahashi; Morihiro Matsuda; Noriyuki Ouchi; Shinji Kihara; Toshiharu Kawamoto; Satoru Sumitsuji; Tohru Funahashi; Yuji Matsuzawa
Diabetes July 2002, Vol.51, 2325-2328. doi:https://doi.org/10.2337/diabetes.51.7.2325
Maturity-Onset Diabetes of the Young Caused by a Balanced Translocation Where the 20q12 Break Point Results in Disruption Upstream of the Coding Region of Hepatocyte Nuclear Factor-4α (HNF4A) Gene
Anna L. Gloyn; Sian Ellard; Maggie Shepherd; Rodney T. Howell; Elizabeth M. Parry; Andrew Jefferson; Elaine R. Levy; Andrew T. Hattersley
Diabetes July 2002, Vol.51, 2329-2333. doi:https://doi.org/10.2337/diabetes.51.7.2329
IL-12p40 Is Associated With Type 1 Diabetes in Caucasian-American Families
Diabetes July 2002, Vol.51, 2334-2336. doi:https://doi.org/10.2337/diabetes.51.7.2334