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Issues
1 August 2002
ISSN 0012-1797
EISSN 1939-327X
Perspectives in Diabetes
The Peroxisome Proliferator-Activated Receptor-γ2 Pro12Ala Polymorphism
Diabetes August 2002, Vol.51, 2341-2347. doi:https://doi.org/10.2337/diabetes.51.8.2341
Cross-Talk Between Iron Metabolism and Diabetes
Diabetes August 2002, Vol.51, 2348-2354. doi:https://doi.org/10.2337/diabetes.51.8.2348
A Genetic Switch in Pancreatic β-Cells: Implications for Differentiation and Haploinsufficiency
Diabetes August 2002, Vol.51, 2355-2362. doi:https://doi.org/10.2337/diabetes.51.8.2355
Metabolism and Signal Transduction
Effects of Benfluorex on Fatty Acid and Glucose Metabolism in Isolated Rat Hepatocytes: From Metabolic Fluxes to Gene Expression
Diabetes August 2002, Vol.51, 2363-2368. doi:https://doi.org/10.2337/diabetes.51.8.2363
Impairment of Insulin Signaling in Human Skeletal Muscle Cells by Co-Culture With Human Adipocytes
Diabetes August 2002, Vol.51, 2369-2376. doi:https://doi.org/10.2337/diabetes.51.8.2369
Regulatory Effects of HMG CoA Reductase Inhibitor and Fish Oils on Apolipoprotein B-100 Kinetics in Insulin-Resistant Obese Male Subjects With Dyslipidemia
Dick C. Chan; Gerald F. Watts; P. Hugh R. Barrett; Lawrence J. Beilin; Trevor G. Redgrave; Trevor A. Mori
Diabetes August 2002, Vol.51, 2377-2386. doi:https://doi.org/10.2337/diabetes.51.8.2377
Association of SH2-Containing Inositol Phosphatase 2 With the Insulin Resistance of Diabetic db/db Mice
Hiroyuki Hori; Toshiyasu Sasaoka; Hajime Ishihara; Tsutomu Wada; Shihou Murakami; Manabu Ishiki; Masashi Kobayashi
Diabetes August 2002, Vol.51, 2387-2394. doi:https://doi.org/10.2337/diabetes.51.8.2387
Synthesis Rate of Muscle Proteins, Muscle Functions, and Amino Acid Kinetics in Type 2 Diabetes
Diabetes August 2002, Vol.51, 2395-2404. doi:https://doi.org/10.2337/diabetes.51.8.2395
Protein Tyrosine Phosphatase 1B Reduction Regulates Adiposity and Expression of Genes Involved in Lipogenesis
Cristina M. Rondinone; James M. Trevillyan; Jill Clampit; Rebecca J. Gum; Cathy Berg; Paul Kroeger; Leigh Frost; Bradley A. Zinker; Regina Reilly; Roger Ulrich; Madeline Butler; Brett P. Monia; Michael R. Jirousek; Jeffrey F. Waring
Diabetes August 2002, Vol.51, 2405-2411. doi:https://doi.org/10.2337/diabetes.51.8.2405
Potentiation of Insulin Signaling in Tissues of Zucker Obese Rats After Acute and Long-Term Treatment With PPARγ Agonists
Guoqiang Jiang; Qing Dallas-Yang; Zhihua Li; Deborah Szalkowski; Franklin Liu; Xiaolan Shen; Margaret Wu; Gaochao Zhou; Thomas Doebber; Joel Berger; David E. Moller; Bei B. Zhang
Diabetes August 2002, Vol.51, 2412-2419. doi:https://doi.org/10.2337/diabetes.51.8.2412
The Antidiabetic Drug Metformin Activates the AMP-Activated Protein Kinase Cascade via an Adenine Nucleotide-Independent Mechanism
Diabetes August 2002, Vol.51, 2420-2425. doi:https://doi.org/10.2337/diabetes.51.8.2420
Liver X Receptors Downregulate 11β-Hydroxysteroid Dehydrogenase Type 1 Expression and Activity
Diabetes August 2002, Vol.51, 2426-2433. doi:https://doi.org/10.2337/diabetes.51.8.2426
Obesity Studies
Selective Antagonism of the NPY Y5 Receptor Does Not Have a Major Effect on Feeding in Rats
Andrew V. Turnbull; Laraine Ellershaw; Dave J. Masters; Susan Birtles; Scott Boyer; Debbie Carroll; Paul Clarkson; Sue J.G. Loxham; Pat McAulay; Joanne L. Teague; Kevin M. Foote; J. Elizabeth Pease; Michael H. Block
Diabetes August 2002, Vol.51, 2441-2449. doi:https://doi.org/10.2337/diabetes.51.8.2441
Improved Insulin Sensitivity and Resistance to Weight Gain in Mice Null for the Ahsg Gene
Suresh T. Mathews; Gurmant P. Singh; Mollie Ranalletta; Vivian J. Cintron; Xiaoling Qiang; Anton Scott Goustin; Kai-Lin Catherine Jen; Maureen J. Charron; Willi Jahnen-Dechent; George Grunberger
Diabetes August 2002, Vol.51, 2450-2458. doi:https://doi.org/10.2337/diabetes.51.8.2450
Decreased Mitochondrial Proton Leak and Reduced Expression of Uncoupling Protein 3 in Skeletal Muscle of Obese Diet-Resistant Women
Mary-Ellen Harper; Robert Dent; Shadi Monemdjou; Véronic Bézaire; Lloyd Van Wyck; George Wells; Gul Nihan Kavaslar; Andre Gauthier; Frédérique Tesson; Ruth McPherson
Diabetes August 2002, Vol.51, 2459-2466. doi:https://doi.org/10.2337/diabetes.51.8.2459
Immunology and Transplantation
Reduced Expression of Th1-Associated Chemokine Receptors on Peripheral Blood Lymphocytes at Diagnosis of Type 1 Diabetes
Diabetes August 2002, Vol.51, 2474-2480. doi:https://doi.org/10.2337/diabetes.51.8.2474
Phagocytosis of Apoptotic Cells by Macrophages From NOD Mice Is Reduced
Diabetes August 2002, Vol.51, 2481-2488. doi:https://doi.org/10.2337/diabetes.51.8.2481
The Role of CC Chemokine Receptor 5 (CCR5) in Islet Allograft Rejection
Reza Abdi; R. Neal Smith; Leila Makhlouf; Nader Najafian; Andrew D. Luster; Hugh Auchincloss, Jr.; Mohamed H. Sayegh
Diabetes August 2002, Vol.51, 2489-2495. doi:https://doi.org/10.2337/diabetes.51.8.2489
Islet Studies
Succinate Is a Preferential Metabolic Stimulus-Coupling Signal for Glucose-Induced Proinsulin Biosynthesis Translation
Diabetes August 2002, Vol.51, 2496-2504. doi:https://doi.org/10.2337/diabetes.51.8.2496
PDX-1 Induces Differentiation of Intestinal Epithelioid IEC-6 Into Insulin-Producing Cells
Shigeru Yoshida; Yoshitaka Kajimoto; Tetsuyuki Yasuda; Hirotaka Watada; Yoshio Fujitani; Hiroshi Kosaka; Takahiro Gotow; Takeshi Miyatsuka; Yutaka Umayahara; Yoshimitsu Yamasaki; Masatsugu Hori
Diabetes August 2002, Vol.51, 2505-2513. doi:https://doi.org/10.2337/diabetes.51.8.2505
Sulfatide Controls Insulin Secretion by Modulation of ATP-sensitive K+-Channel Activity and Ca2+-Dependent Exocytosis in Rat Pancreatic β-Cells
Karsten Buschard; Marianne Høy; Krister Bokvist; Hervør L. Olsen; Sten Madsbad; Pam Fredman; Jesper Gromada
Diabetes August 2002, Vol.51, 2514-2521. doi:https://doi.org/10.2337/diabetes.51.8.2514
Ouabain Suppresses Glucose-Induced Mitochondrial ATP Production and Insulin Release by Generating Reactive Oxygen Species in Pancreatic Islets
Mariko Kajikawa; Shimpei Fujimoto; Yoshiyuki Tsuura; Eri Mukai; Tomomi Takeda; Yoshiyuki Hamamoto; Mihoko Takehiro; Jun Fujita; Yuichiro Yamada; Yutaka Seino
Diabetes August 2002, Vol.51, 2522-2529. doi:https://doi.org/10.2337/diabetes.51.8.2522
Islet Hyperperfusion During Prediabetic Phase in OLETF Rats, a Model of Type 2 Diabetes
Diabetes August 2002, Vol.51, 2530-2535. doi:https://doi.org/10.2337/diabetes.51.8.2530
Stimulation of Acetyl-CoA Carboxylase Gene Expression by Glucose Requires Insulin Release and Sterol Regulatory Element Binding Protein 1c in Pancreatic MIN6 β-Cells
Chrysovalantis Andreolas; Gabriela da Silva Xavier; Frederique Diraison; Chao Zhao; Aniko Varadi; Fernando Lopez-Casillas; Pascal Ferré; Fabienne Foufelle; Guy A. Rutter
Diabetes August 2002, Vol.51, 2536-2545. doi:https://doi.org/10.2337/diabetes.51.8.2536
Foxa2 Controls Pdx1 Gene Expression in Pancreatic β-Cells In Vivo
Catherine S. Lee; Newman J. Sund; Marko Z. Vatamaniuk; Franz M. Matschinsky; Doris A. Stoffers; Klaus H. Kaestner
Diabetes August 2002, Vol.51, 2546-2551. doi:https://doi.org/10.2337/diabetes.51.8.2546
Increased Glucose Sensitivity of Stimulus-Secretion Coupling in Islets From Psammomys obesus After Diet Induction of Diabetes
Jose A.G. Pertusa; Rafael Nesher; Nurit Kaiser; Erol Cerasi; Jean-Claude Henquin; Jean-Christophe Jonas
Diabetes August 2002, Vol.51, 2552-2560. doi:https://doi.org/10.2337/diabetes.51.8.2552
Pathophysiology
Maternal First-Trimester Enterovirus Infection and Future Risk of Type 1 Diabetes in the Exposed Fetus
Hanna R. Viskari; Merja Roivainen; Antti Reunanen; Janne Pitkäniemi; Karita Sadeharju; Pentti Koskela; Tapani Hovi; Pauli Leinikki; Pekka Vilja; Jaakko Tuomilehto; Heikki Hyöty
Diabetes August 2002, Vol.51, 2568-2571. doi:https://doi.org/10.2337/diabetes.51.8.2568
Nitric Oxide Synthase Inhibition Reduces Glucose Uptake During Exercise in Individuals With Type 2 Diabetes More Than in Control Subjects
Diabetes August 2002, Vol.51, 2572-2580. doi:https://doi.org/10.2337/diabetes.51.8.2572
Association of the Pro12Ala Polymorphism in the PPAR-γ2 Gene With 3-Year Incidence of Type 2 Diabetes and Body Weight Change in the Finnish Diabetes Prevention Study
Virpi I. Lindi; Matti I.J. Uusitupa; Jaana Lindström; Anne Louheranta; Johan G. Eriksson; Timo T. Valle; Helena Hämäläinen; Pirjo Ilanne-Parikka; Sirkka Keinänen-Kiukaanniemi; Markku Laakso; Jaakko Tuomilehto; for the Finnish Diabetes Prevention Study Group
Diabetes August 2002, Vol.51, 2581-2586. doi:https://doi.org/10.2337/diabetes.51.8.2581
Impaired Long-Chain Fatty Acid Oxidation and Contractile Dysfunction in the Obese Zucker Rat Heart
Martin E. Young; Patrick H. Guthrie; Peter Razeghi; Brendan Leighton; Shahrzad Abbasi; Sarita Patil; Keith A. Youker; Heinrich Taegtmeyer
Diabetes August 2002, Vol.51, 2587-2595. doi:https://doi.org/10.2337/diabetes.51.8.2587
Cerivastatin Improves Insulin Sensitivity and Insulin Secretion in Early-State Obese Type 2 Diabetes
J.A. Paniagua; J. López-Miranda; A. Escribano; F.J. Berral; C. Marín; D. Bravo; E. Paz-Rojas; P. Gómez; M. Barcos; J.A. Moreno; F. Pérez-Jiménez
Diabetes August 2002, Vol.51, 2596-2603. doi:https://doi.org/10.2337/diabetes.51.8.2596
Complications
Hepatocyte Growth Factor Prevents Endothelial Cell Death Through Inhibition of bax Translocation From Cytosol to Mitochondrial Membrane
Hironori Nakagami; Ryuichi Morishita; Kei Yamamoto; Yoshiaki Taniyama; Motokuni Aoki; Keita Yamasaki; Kunio Matsumoto; Toshikazu Nakamura; Yasufumi Kaneda; Toshio Ogihara
Diabetes August 2002, Vol.51, 2604-2611. doi:https://doi.org/10.2337/diabetes.51.8.2604
Effects of Mesangium Glycation on Matrix Metalloproteinase Activities: Possible Role in Diabetic Nephropathy
Diabetes August 2002, Vol.51, 2612-2618. doi:https://doi.org/10.2337/diabetes.51.8.2612
Dissection of Metabolic, Vascular, and Nerve Conduction Interrelationships in Experimental Diabetic Neuropathy by Cyclooxygenase Inhibition and Acetyl-l-Carnitine Administration
Rodica Pop-Busui; Victor Marinescu; Carol Van Huysen; Fei Li; Kelli Sullivan; Douglas A. Greene; Dennis Larkin; Martin J. Stevens
Diabetes August 2002, Vol.51, 2619-2628. doi:https://doi.org/10.2337/diabetes.51.8.2619
Low Circulating Levels of Insulin-Like Growth Factor Binding Protein-1 (IGFBP-1) Are Closely Associated With the Presence of Macrovascular Disease and Hypertension in Type 2 Diabetes
Adrian H. Heald; K.W. Siddals; William Fraser; William Taylor; Kalpana Kaushal; Julie Morris; Robert J. Young; Anne White; J. Martin Gibson
Diabetes August 2002, Vol.51, 2629-2636. doi:https://doi.org/10.2337/diabetes.51.8.2629
Silent Coronary Atheromatosis in Type 1 Diabetic Patients and Its Relation to Long-Term Glycemic Control
Diabetes August 2002, Vol.51, 2637-2641. doi:https://doi.org/10.2337/diabetes.51.8.2637
Factor Analysis of Metabolic Syndrome Using Directly Measured Insulin Sensitivity: The Insulin Resistance Atherosclerosis Study
Anthony J.G. Hanley; Andrew J. Karter; Andreas Festa; Ralph D’Agostino, Jr.; Lynne E. Wagenknecht; Peter Savage; Russell P. Tracy; Mohammed F. Saad; Steven Haffner
Diabetes August 2002, Vol.51, 2642-2647. doi:https://doi.org/10.2337/diabetes.51.8.2642