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Perspectives in Diabetes

The Succinate Mechanism of Insulin Release

Leonard A. Fahien; Michael J. MacDonald

Abstracts

View articletitled, The Succinate Mechanism of Insulin Release

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Topics: coenzyme a , glucose , insulin , mevalonate , succinates

Diabetes September 2002, Vol.51, 2669-2676. doi:https://doi.org/10.2337/diabetes.51.9.2669

Metabolism and Signal Transduction

Long-Term Treatment With Dipeptidyl Peptidase IV Inhibitor Improves Hepatic and Peripheral Insulin Sensitivity in the VDF Zucker Rat: A Euglycemic-Hyperinsulinemic Clamp Study

John A. Pospisilik; Sara G. Stafford; Hans-Ulrich Demuth; Christopher H.S. McIntosh; Raymond A. Pederson

Abstracts

View articletitled, Long-Term Treatment With Dipeptidyl Peptidase IV Inhibitor Improves Hepatic and Peripheral Insulin Sensitivity in the VDF Zucker Rat: A Euglycemic-Hyperinsulinemic Clamp Study

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Topics: adipocytes , glucagon , glucose , glucose tolerance , insulin

Diabetes September 2002, Vol.51, 2677-2683. doi:https://doi.org/10.2337/diabetes.51.9.2677

Regulation of Dietary Fatty Acid Entrapment in Subcutaneous Adipose Tissue and Skeletal Muscle

Kevin Evans; Graham C. Burdge; Stephen A. Wootton; Mo L. Clark; Keith N. Frayn

Abstracts

View articletitled, Regulation of Dietary Fatty Acid Entrapment in Subcutaneous Adipose Tissue and Skeletal Muscle

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Topics: entrapment (morphologic abnormality) , fatty acids , transluminal attenuation gradient , adipose tissue , diet

Diabetes September 2002, Vol.51, 2684-2690. doi:https://doi.org/10.2337/diabetes.51.9.2684

Troglitazone Treatment Increases Protein Kinase B Phosphorylation in Skeletal Muscle of Normoglycemic Subjects at Risk for the Development of Type 2 Diabetes

Marco M. Meyer; Klaus Levin; Thomas Grimmsmann; Nina Perwitz; Alexandra Eirich; Henning Beck-Nielsen; Harald H. Klein

Abstracts

View articletitled, Troglitazone Treatment Increases Protein Kinase B Phosphorylation in Skeletal Muscle of Normoglycemic Subjects at Risk for the Development of Type 2 Diabetes

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Topics: 1-phosphatidylinositol 3-kinase , glucose , insulin , phosphorylation , skeletal muscles

Diabetes September 2002, Vol.51, 2691-2697. doi:https://doi.org/10.2337/diabetes.51.9.2691

Muscle Glucose Uptake Does Not Increase When Only Local Arterial Glucose Concentration Is Increased

Kenneth Zierler; Reubin Andres

Abstracts

View articletitled, Muscle Glucose Uptake Does Not Increase When Only Local Arterial Glucose Concentration Is Increased

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Topics: forearm , glucose , glucose uptake , infusion procedures

Diabetes September 2002, Vol.51, 2698-2702. doi:https://doi.org/10.2337/diabetes.51.9.2698

Isoform-Specific Regulation of 5′ AMP-Activated Protein Kinase in Skeletal Muscle From Obese Zucker (fa/fa) Rats in Response to Contraction

Brian R. Barnes; Jeffrey W. Ryder; Tatiana L. Steiler; Lee G.D. Fryer; David Carling; Juleen R. Zierath

Abstracts

View articletitled, Isoform-Specific Regulation of 5′ AMP-Activated Protein Kinase in Skeletal Muscle From Obese Zucker (fa/fa) Rats in Response to Contraction

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Topics: 1-phosphatidylinositol 3-kinase , ampk , glucose transport , hypoxia , insulin

Diabetes September 2002, Vol.51, 2703-2708. doi:https://doi.org/10.2337/diabetes.51.9.2703

Expression of Connective Tissue Growth Factor Is Increased in Injured Myocardium Associated With Protein Kinase C β2 Activation and Diabetes

Kerrie J. Way; Keiji Isshiki; Kiyoshi Suzuma; Tamotsu Yokota; Dmitriy Zvagelsky; Frederick J. Schoen; George E. Sandusky; Penelope A. Pechous; Chris J. Vlahos; Hisao Wakasaki; George L. King

Abstracts

View articletitled, Expression of Connective Tissue Growth Factor Is Increased in Injured Myocardium Associated With Protein Kinase C β2 Activation and Diabetes

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Topics: connective tissue growth factor , heart , mice , mice, transgenic , myocardium

Diabetes September 2002, Vol.51, 2709-2718. doi:https://doi.org/10.2337/diabetes.51.9.2709

Need for GLUT4 Activation to Reach Maximum Effect of Insulin-Mediated Glucose Uptake in Brown Adipocytes Isolated From GLUT4myc-Expressing Mice

Daniel Konrad; Philip J. Bilan; Zafar Nawaz; Gary Sweeney; Wenyan Niu; Zhi Liu; Costin N. Antonescu; Assaf Rudich; Amira Klip

Abstracts

View articletitled, Need for GLUT4 Activation to Reach Maximum Effect of Insulin-Mediated Glucose Uptake in Brown Adipocytes Isolated From GLUT4myc-Expressing Mice

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Topics: adipocytes , insulin , mice , deoxyglucose , wortmannin

Diabetes September 2002, Vol.51, 2719-2726. doi:https://doi.org/10.2337/diabetes.51.9.2719

Obesity Studies

Transplantation of Adipose Tissue Lacking Leptin Is Unable to Reverse the Metabolic Abnormalities Associated With Lipoatrophy

Carlo Colombo; Jaime J. Cutson; Toshimasa Yamauchi; Charles Vinson; Takashi Kadowaki; Oksana Gavrilova; Marc L. Reitman

Abstracts

View articletitled, Transplantation of Adipose Tissue Lacking Leptin Is Unable to Reverse the Metabolic Abnormalities Associated With Lipoatrophy

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Topics: leptin , mice , transplantation , lipodystrophy , infusion procedures

Diabetes September 2002, Vol.51, 2727-2733. doi:https://doi.org/10.2337/diabetes.51.9.2727

Androgens Decrease Plasma Adiponectin, an Insulin-Sensitizing Adipocyte-Derived Protein

Hitoshi Nishizawa; Iichiro Shimomura; Ken Kishida; Norikazu Maeda; Hiroshi Kuriyama; Hiroyuki Nagaretani; Morihiro Matsuda; Hidehiko Kondo; Naoki Furuyama; Shinji Kihara; Tadashi Nakamura; Yoshihiro Tochino; Tohru Funahashi; Yuji Matsuzawa

Abstracts

View articletitled, Androgens Decrease Plasma Adiponectin, an Insulin-Sensitizing Adipocyte-Derived Protein

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Topics: adipocytes , adiponectin , plasma , testosterone , insulin

Diabetes September 2002, Vol.51, 2734-2741. doi:https://doi.org/10.2337/diabetes.51.9.2734

Delayed Transcapillary Transport of Insulin to Muscle Interstitial Fluid in Obese Subjects

Mikaela Sjöstrand; Soffia Gudbjörnsdottir; Agneta Holmäng; Lars Lönn; Lena Strindberg; Peter Lönnroth

Abstracts

View articletitled, Delayed Transcapillary Transport of Insulin to Muscle Interstitial Fluid in Obese Subjects

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Topics: glucose , insulin , obesity , inulin

Diabetes September 2002, Vol.51, 2742-2748. doi:https://doi.org/10.2337/diabetes.51.9.2742

Islet Studies

Role of ATP Production and Uncoupling Protein-2 in the Insulin Secretory Defect Induced by Chronic Exposure to High Glucose or Free Fatty Acids and Effects of Peroxisome Proliferator-Activated Receptor-γ Inhibition

Giovanni Patanè; Marcello Anello; Salvatore Piro; Riccardo Vigneri; Francesco Purrello; Agata Maria Rabuazzo

Abstracts

View articletitled, Role of ATP Production and Uncoupling Protein-2 in the Insulin Secretory Defect Induced by Chronic Exposure to High Glucose or Free Fatty Acids and Effects of Peroxisome Proliferator-Activated Receptor-γ Inhibition

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Topics: glucose , insulin , peroxisome proliferator-activated receptors

Diabetes September 2002, Vol.51, 2749-2756. doi:https://doi.org/10.2337/diabetes.51.9.2749

Glucose-Sensing in Glucagon-Like Peptide-1-Secreting Cells

Frank Reimann; Fiona M. Gribble

Abstracts

View articletitled, Glucose-Sensing in Glucagon-Like Peptide-1-Secreting Cells

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Topics: bodily secretions , glucagon-like peptide 1 , glucose , tolbutamide

Diabetes September 2002, Vol.51, 2757-2763. doi:https://doi.org/10.2337/diabetes.51.9.2757

Modulation of Glucocorticoid-Induced GAD Expression in Pancreatic β-Cells by Transcriptional Activation of the GAD67 Promoter and Its Possible Effect on the Development of Diabetes

Kyung Soo Kim; Yup Kang; Sung E. Choi; Ju Hee Kim; Hyeon Man Kim; Beichen Sun; Hee-Sook Jun; Ji-Won Yoon

Abstracts

View articletitled, Modulation of Glucocorticoid-Induced GAD Expression in Pancreatic β-Cells by Transcriptional Activation of the GAD67 Promoter and Its Possible Effect on the Development of Diabetes

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Topics: dexamethasone , generalized anxiety disorder , glucocorticoids , pancreas , rna, messenger

Diabetes September 2002, Vol.51, 2764-2772. doi:https://doi.org/10.2337/diabetes.51.9.2764

Plasma Membrane Ca²⁺-ATPase Overexpression Reduces Ca²⁺ Oscillations and Increases Insulin Release Induced by Glucose in Insulin-Secreting BRIN-BD11 Cells

Adama Kamagate; André Herchuelz; Françoise Van Eylen

Abstracts

View articletitled, Plasma Membrane Ca2+-ATPase Overexpression Reduces Ca2+ Oscillations and Increases Insulin Release Induced by Glucose in Insulin-Secreting BRIN-BD11 Cells

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Topics: glucose , insulin , protein overexpression , spatial vectors , clone cells

Diabetes September 2002, Vol.51, 2773-2788. doi:https://doi.org/10.2337/diabetes.51.9.2773

Differential Interactions of Nateglinide and Repaglinide on the Human β-Cell Sulphonylurea Receptor 1

Ann Maria K. Hansen; Inge T. Christensen; John Bondo Hansen; Richard D. Carr; Frances M. Ashcroft; Philip Wahl

Abstracts

View articletitled, Differential Interactions of Nateglinide and Repaglinide on the Human β-Cell Sulphonylurea Receptor 1

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Topics: nateglinide , repaglinide , tolbutamide , abcc8 gene , glyburide

Diabetes September 2002, Vol.51, 2789-2795. doi:https://doi.org/10.2337/diabetes.51.9.2789

Pathophysiology

Preservation of Pancreatic β-Cell Function and Prevention of Type 2 Diabetes by Pharmacological Treatment of Insulin Resistance in High-Risk Hispanic Women

Thomas A. Buchanan; Anny H. Xiang; Ruth K. Peters; Siri L. Kjos; Aura Marroquin; Jose Goico; Cesar Ochoa; Sylvia Tan; Kathleen Berkowitz; Howard N. Hodis; Stanley P. Azen

Abstracts

View articletitled, Preservation of Pancreatic β-Cell Function and Prevention of Type 2 Diabetes by Pharmacological Treatment of Insulin Resistance in High-Risk Hispanic Women

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Topics: diabetes mellitus, type 2 , insulin , insulin resistance , troglitazone

Diabetes September 2002, Vol.51, 2796-2803. doi:https://doi.org/10.2337/diabetes.51.9.2796

Complications

Diacylglycerol Production and Protein Kinase C Activity Are Increased in a Mouse Model of Diabetic Embryopathy

Yuji Hiramatsu; Naotaka Sekiguchi; Michio Hayashi; Keiji Isshiki; Tamotsu Yokota; George L. King; Mary R. Loeken

Abstracts

View articletitled, Diacylglycerol Production and Protein Kinase C Activity Are Increased in a Mouse Model of Diabetic Embryopathy

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Topics: decidua , embryo , glucose , hyperglycemia , mice

Diabetes September 2002, Vol.51, 2804-2810. doi:https://doi.org/10.2337/diabetes.51.9.2804

Maternal Diabetes Increases the Risk of Caudal Regression Caused by Retinoic Acid

Billy W.H. Chan; Kwok-siu Chan; Tsuyoshi Koide; Sau-man Yeung; Maran B.W. Leung; Andrew J. Copp; Mary R. Loeken; Toshihiko Shiroishi; Alisa S.W. Shum

Abstracts

View articletitled, Maternal Diabetes Increases the Risk of Caudal Regression Caused by Retinoic Acid

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Topics: caudal dysplasia sequence , embryo , gestational diabetes , mice , tretinoin

Diabetes September 2002, Vol.51, 2811-2816. doi:https://doi.org/10.2337/diabetes.51.9.2811

Nitrosative Stress, Uric Acid, and Peripheral Nerve Function in Early Type 1 Diabetes

Robert D. Hoeldtke; Kimberly D. Bryner; Daniel R. McNeill; Gerald R. Hobbs; Jack E. Riggs; Sarah S. Warehime; Ian Christie; Gary Ganser; Knox Van Dyke

Abstracts

View articletitled, Nitrosative Stress, Uric Acid, and Peripheral Nerve Function in Early Type 1 Diabetes

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Topics: autonomic cardiovascular function , diabetes mellitus, type 1 , hemoglobin a, glycosylated , nitrosative stress , peripheral nerves

Diabetes September 2002, Vol.51, 2817-2825. doi:https://doi.org/10.2337/diabetes.51.9.2817

The AGE Inhibitor Pyridoxamine Inhibits Development of Retinopathy in Experimental Diabetes

Alan Stitt; Thomas A. Gardiner; Nathan L. Anderson; Paul Canning; Norma Frizzell; Noel Duffy; Cliona Boyle; Andrzej S. Januszewski; Mark Chachich; John W. Baynes; Suzanne R. Thorpe

Abstracts

View articletitled, The AGE Inhibitor Pyridoxamine Inhibits Development of Retinopathy in Experimental Diabetes

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Topics: basement membrane , blood capillaries , diabetes mellitus, experimental , diabetic retinopathy , laminin

Diabetes September 2002, Vol.51, 2826-2832. doi:https://doi.org/10.2337/diabetes.51.9.2826

Peroxynitrite Induces Formation of N^ε-(Carboxymethyl)Lysine by the Cleavage of Amadori Product and Generation of Glucosone and Glyoxal From Glucose: Novel Pathways for Protein Modification by Peroxynitrite

Ryoji Nagai; Yuka Unno; Miki Cristina Hayashi; Shuichi Masuda; Fumitaka Hayase; Naohide Kinae; Seikoh Horiuchi

Abstracts

View articletitled, Peroxynitrite Induces Formation of Nε-(Carboxymethyl)Lysine by the Cleavage of Amadori Product and Generation of Glucosone and Glyoxal From Glucose: Novel Pathways for Protein Modification by Peroxynitrite

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Topics: 3-nitrotyrosine , amadori product , glucose , glyoxal , high pressure liquid chromatography procedure

Diabetes September 2002, Vol.51, 2833-2839. doi:https://doi.org/10.2337/diabetes.51.9.2833

Type 1 And Type 2 Diabetic Patients Display Different Patterns of Cellular Microparticles

Florence Sabatier; Patrice Darmon; Benedicte Hugel; Valery Combes; Marielle Sanmarco; Jean-Gabriel Velut; Dominique Arnoux; Phillipe Charpiot; Jean-Marie Freyssinet; Charles Oliver; Jose Sampol; Francoise Dignat-George

Abstracts

View articletitled, Type 1 And Type 2 Diabetic Patients Display Different Patterns of Cellular Microparticles

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Topics: cell-derived microparticles , earth microbiome project , blood platelets , vascular complications , donors

Diabetes September 2002, Vol.51, 2840-2845. doi:https://doi.org/10.2337/diabetes.51.9.2840

Augmentation of the Neutrophil Respiratory Burst Through the Action of Advanced Glycation End Products: A Potential Contributor to Vascular Oxidant Stress

Richard K.M. Wong; Andrew I. Pettit; Joan E. Davies; Leong L. Ng

Abstracts

View articletitled, Augmentation of the Neutrophil Respiratory Burst Through the Action of Advanced Glycation End Products: A Potential Contributor to Vascular Oxidant Stress

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Topics: albumins , neutrophils , respiratory burst , oxidants , stress

Diabetes September 2002, Vol.51, 2846-2853. doi:https://doi.org/10.2337/diabetes.51.9.2846

Genetics

The Prevalent Glu23Lys Polymorphism in the Potassium Inward Rectifier 6.2 (KIR6.2) Gene Is Associated With Impaired Glucagon Suppression in Response to Hyperglycemia

Otto Tschritter; Michael Stumvoll; Fausto Machicao; Martin Holzwarth; Melanie Weisser; Elke Maerker; Anna Teigeler; Hans Häring; Andreas Fritsche

Abstracts

View articletitled, The Prevalent Glu23Lys Polymorphism in the Potassium Inward Rectifier 6.2 (KIR6.2) Gene Is Associated With Impaired Glucagon Suppression in Response to Hyperglycemia

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Topics: glucagon , glucose , hyperglycemia , hyperglycemic agents , insulin

Diabetes September 2002, Vol.51, 2854-2860. doi:https://doi.org/10.2337/diabetes.51.9.2854

Liver Pyruvate Kinase Polymorphisms Are Associated With Type 2 Diabetes in Northern European Caucasians

Hua Wang; Winston Chu; Swapan K. Das; Qianfang Ren; Sandra J. Hasstedt; Steven C. Elbein

Abstracts

View articletitled, Liver Pyruvate Kinase Polymorphisms Are Associated With Type 2 Diabetes in Northern European Caucasians

Supplementary data

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Topics: diabetes mellitus, type 2 , genes , liver , polymorphism , pyruvate kinase

Diabetes September 2002, Vol.51, 2861-2865. doi:https://doi.org/10.2337/diabetes.51.9.2861

Brief Genetics Report

A Comprehensive, Statistically Powered Analysis of GAD2 in Type 1 Diabetes

Gillian C.L. Johnson; Felicity Payne; Sarah Nutland; Helen Stevens; Eva Tuomilehto-Wolf; Jaakko Tuomilehto; John A. Todd

Abstracts

View articletitled, A Comprehensive, Statistically Powered Analysis of GAD2 in Type 1 Diabetes

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Topics: diabetes mellitus, type 1 , polymorphism , haplotypes , single nucleotide polymorphism , genes

Diabetes September 2002, Vol.51, 2866-2870. doi:https://doi.org/10.2337/diabetes.51.9.2866

Polymorphic Susceptibility to the Molecular Causes of Neural Tube Defects During Diabetic Embryopathy

Lydie Pani; Melissa Horal; Mary R. Loeken

Abstracts

View articletitled, Polymorphic Susceptibility to the Molecular Causes of Neural Tube Defects During Diabetic Embryopathy

Supplementary data

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Topics: embryo , genes , gestational diabetes , hyperglycemia , mice

Diabetes September 2002, Vol.51, 2871-2874. doi:https://doi.org/10.2337/diabetes.51.9.2871

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