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Volume 52, Issue 1
1 January 2003
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ISSN 0012-1797
EISSN 1939-327X
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Perspectives in Diabetes

Are Oxidative Stress−Activated Signaling Pathways Mediators of Insulin Resistance and β-Cell Dysfunction?
Joseph L. Evans; Ira D. Goldfine; Betty A. Maddux; Gerold M. Grodsky
View articletitled, Are Oxidative Stress−Activated Signaling Pathways Mediators of Insulin Resistance and β-Cell Dysfunction?
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Diabetes January 2003, Vol.52, 1-8. doi:https://doi.org/10.2337/diabetes.52.1.1

Metabolism and Signal Transduction

Regulation of Glycogen Synthase by Glucose and Glycogen: A Possible Role for AMP-Activated Protein Kinase
Reza Halse; Lee G.D. Fryer; James G. McCormack; David Carling; Stephen J. Yeaman
View articletitled, Regulation of Glycogen Synthase by Glucose and Glycogen<span class="subtitle-colon">: </span><span class="subtitle">A Possible Role for AMP-Activated Protein Kinase</span>
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Diabetes January 2003, Vol.52, 9-15. doi:https://doi.org/10.2337/diabetes.52.1.9
Plasma Ghrelin Concentrations Are Not Regulated by Glucose or Insulin: A Double-Blind, Placebo-Controlled Crossover Clamp Study
Georg Schaller; Adele Schmidt; Johannes Pleiner; Wolfgang Woloszczuk; Michael Wolzt; Anton Luger
View articletitled, Plasma Ghrelin Concentrations Are Not Regulated by Glucose or Insulin<span class="subtitle-colon">: </span><span class="subtitle">A Double-Blind, Placebo-Controlled Crossover Clamp Study</span>
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Diabetes January 2003, Vol.52, 16-20. doi:https://doi.org/10.2337/diabetes.52.1.16
Reduction of Protein Tyrosine Phosphatase 1B Increases Insulin-Dependent Signaling in ob/ob Mice
Rebecca J. Gum; Lori L. Gaede; Sandra L. Koterski; Matthew Heindel; Jill E. Clampit; Bradley A. Zinker; James M. Trevillyan; Roger G. Ulrich; Michael R. Jirousek; Cristina M. Rondinone
View articletitled, Reduction of Protein Tyrosine Phosphatase 1B Increases Insulin-Dependent Signaling in <em>ob/ob</em> Mice
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Diabetes January 2003, Vol.52, 21-28. doi:https://doi.org/10.2337/diabetes.52.1.21
Dietary Cod Protein Restores Insulin-Induced Activation of Phosphatidylinositol 3-Kinase/Akt and GLUT4 Translocation to the T-Tubules in Skeletal Muscle of High-Fat-Fed Obese Rats
Frédéric Tremblay; Charles Lavigne; Hélène Jacques; André Marette
View articletitled, Dietary Cod Protein Restores Insulin-Induced Activation of Phosphatidylinositol 3-Kinase/Akt and GLUT4 Translocation to the T-Tubules in Skeletal Muscle of High-Fat-Fed Obese Rats
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Diabetes January 2003, Vol.52, 29-37. doi:https://doi.org/10.2337/diabetes.52.1.29
Elevated Free Fatty Acids Impair Glucose Metabolism in Women: Decreased Stimulation of Muscle Glucose Uptake and Suppression of Splanchnic Glucose Production During Combined Hyperinsulinemia and Hyperglycemia
Pankaj Shah; Adrian Vella; Ananda Basu; Rita Basu; Aron Adkins; W. Frederick Schwenk; C. Michael Johnson; K. Sreekumaran Nair; Michael D. Jensen; Robert A. Rizza
View articletitled, Elevated Free Fatty Acids Impair Glucose Metabolism in Women<span class="subtitle-colon">: </span><span class="subtitle">Decreased Stimulation of Muscle Glucose Uptake and Suppression of Splanchnic Glucose Production During Combined Hyperinsulinemia and Hyperglycemia</span>
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Diabetes January 2003, Vol.52, 38-42. doi:https://doi.org/10.2337/diabetes.52.1.38

Obesity Studies

Differential Regulation of Lipogenesis and Leptin Production by Independent Signaling Pathways and Rosiglitazone During Human Adipocyte Differentiation
Nayan G. Patel; Julie C. Holder; Stephen A. Smith; Sudesh Kumar; Margaret C. Eggo
View articletitled, Differential Regulation of Lipogenesis and Leptin Production by Independent Signaling Pathways and Rosiglitazone During Human Adipocyte Differentiation
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Diabetes January 2003, Vol.52, 43-50. doi:https://doi.org/10.2337/diabetes.52.1.43
Diabetes-Induced, Progressive Endometrial Involution Characterization of Periluminal Epithelial Lipoatrophy
David R. Garris; Bryan L. Garris
View articletitled, Diabetes-Induced, Progressive Endometrial Involution Characterization of Periluminal Epithelial Lipoatrophy
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Diabetes January 2003, Vol.52, 51-58. doi:https://doi.org/10.2337/diabetes.52.1.51

Immunology and Transplantation

Purified Allogeneic Hematopoietic Stem Cell Transplantation Blocks Diabetes Pathogenesis in NOD Mice
Georg F. Beilhack; Yolanda C. Scheffold; Irving L. Weissman; Cariel Taylor; Libuse Jerabek; Matthew J. Burge; Marilyn A. Masek; Judith A. Shizuru
View articletitled, Purified Allogeneic Hematopoietic Stem Cell Transplantation Blocks Diabetes Pathogenesis in NOD Mice
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Diabetes January 2003, Vol.52, 59-68. doi:https://doi.org/10.2337/diabetes.52.1.59
Survival and Maturation of Microencapsulated Porcine Neonatal Pancreatic Cell Clusters Transplanted into Immunocompetent Diabetic Mice
Abdulkadir Omer; Valérie F. Duvivier-Kali; Nitin Trivedi; Karen Wilmot; Susan Bonner-Weir; Gordon C. Weir
View articletitled, Survival and Maturation of Microencapsulated Porcine Neonatal Pancreatic Cell Clusters Transplanted into Immunocompetent Diabetic Mice
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Diabetes January 2003, Vol.52, 69-75. doi:https://doi.org/10.2337/diabetes.52.1.69

Islet Studies

All-Trans Retinoic Acid Induces Differentiation of Ducts and Endocrine Cells by Mesenchymal/Epithelial Interactions in Embryonic Pancreas
Sidhartha Singh Tulachan; Ryuichiro Doi; Yoshiya Kawaguchi; Shoichiro Tsuji; Sanae Nakajima; Toshihiko Masui; Masayuki Koizumi; Eiji Toyoda; Tomohiko Mori; Daisuke Ito; Kazuhiro Kami; Koji Fujimoto; Masayuki Imamura
View articletitled, All-<em>Trans</em> Retinoic Acid Induces Differentiation of Ducts and Endocrine Cells by Mesenchymal/Epithelial Interactions in Embryonic Pancreas
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Diabetes January 2003, Vol.52, 76-84. doi:https://doi.org/10.2337/diabetes.52.1.76
Role for VPAC2 Receptor-Mediated Signals in Pancreas Development
Latif Rachdi; Jean-Claude Marie; Raphael Scharfmann
View articletitled, Role for VPAC2 Receptor-Mediated Signals in Pancreas Development
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Diabetes January 2003, Vol.52, 85-92. doi:https://doi.org/10.2337/diabetes.52.1.85
Improvement of the Mitochondrial Antioxidant Defense Status Prevents Cytokine-Induced Nuclear Factor-κB Activation in Insulin-Producing Cells
Anna Karenina Azevedo-Martins; Stephan Lortz; Sigurd Lenzen; Rui Curi; Decio L. Eizirik; Markus Tiedge
View articletitled, Improvement of the Mitochondrial Antioxidant Defense Status Prevents Cytokine-Induced Nuclear Factor-κB Activation in Insulin-Producing Cells
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Diabetes January 2003, Vol.52, 93-101. doi:https://doi.org/10.2337/diabetes.52.1.93
β-Cell Deficit and Increased β-Cell Apoptosis in Humans With Type 2 Diabetes
Alexandra E. Butler; Juliette Janson; Susan Bonner-Weir; Robert Ritzel; Robert A. Rizza; Peter C. Butler
View articletitled, β-Cell Deficit and Increased β-Cell Apoptosis in Humans With Type 2 Diabetes
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Diabetes January 2003, Vol.52, 102-110. doi:https://doi.org/10.2337/diabetes.52.1.102
Glucose Regulates the Release of Orexin-A From the Endocrine Pancreas
Raogo Ouedraogo; Erik Näslund; Annette L. Kirchgessner
View articletitled, Glucose Regulates the Release of Orexin-A From the Endocrine Pancreas
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Diabetes January 2003, Vol.52, 111-117. doi:https://doi.org/10.2337/diabetes.52.1.111
Measurements of Insulin Secretory Capacity and Glucose Tolerance to Predict Pancreatic β-Cell Mass In Vivo in the Nicotinamide/Streptozotocin Göttingen Minipig, a Model of Moderate Insulin Deficiency and Diabetes
Marianne O. Larsen; Bidda Rolin; Michael Wilken; Richard D. Carr; Carsten F. Gotfredsen
View articletitled, Measurements of Insulin Secretory Capacity and Glucose Tolerance to Predict Pancreatic β-Cell Mass In Vivo in the Nicotinamide/Streptozotocin Göttingen Minipig, a Model of Moderate Insulin Deficiency and Diabetes
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Diabetes January 2003, Vol.52, 118-123. doi:https://doi.org/10.2337/diabetes.52.1.118
Glucagon-Like Peptide 1 Induces Pancreatic β-Cell Proliferation Via Transactivation of the Epidermal Growth Factor Receptor
Jean Buteau; Sylvain Foisy; Erik Joly; Marc Prentki
View articletitled, Glucagon-Like Peptide 1 Induces Pancreatic β-Cell Proliferation Via Transactivation of the Epidermal Growth Factor Receptor
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Diabetes January 2003, Vol.52, 124-132. doi:https://doi.org/10.2337/diabetes.52.1.124

Pathophysiology

Effects of Acute Insulin Excess and Deficiency on Gluconeogenesis and Glycogenolysis in Type 1 Diabetes
Guenther Boden; Peter Cheung; Carol Homko
View articletitled, Effects of Acute Insulin Excess and Deficiency on Gluconeogenesis and Glycogenolysis in Type 1 Diabetes
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Diabetes January 2003, Vol.52, 133-137. doi:https://doi.org/10.2337/diabetes.52.1.133
Intramyocellular Lipid and Insulin Resistance: A Longitudinal In Vivo 1H-Spectroscopic Study in Zucker Diabetic Fatty Rats
Johanna Kuhlmann; Claudia Neumann-Haefelin; Ulrich Belz; Jürgen Kalisch; Hans-Paul Juretschke; Marion Stein; Elke Kleinschmidt; Werner Kramer; Andreas W. Herling
View articletitled, Intramyocellular Lipid and Insulin Resistance<span class="subtitle-colon">: </span><span class="subtitle">A Longitudinal In Vivo <sup>1</sup>H-Spectroscopic Study in Zucker Diabetic Fatty Rats</span>
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Diabetes January 2003, Vol.52, 138-144. doi:https://doi.org/10.2337/diabetes.52.1.138
Apolipoprotein-E Influences Aspects of Intellectual Ability in Type 1 Diabetes
Stewart C. Ferguson; Ian J. Deary; Julie C. Evans; Sian Ellard; Andrew T. Hattersley; Brian M. Frier
View articletitled, Apolipoprotein-E Influences Aspects of Intellectual Ability in Type 1 Diabetes
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Diabetes January 2003, Vol.52, 145-148. doi:https://doi.org/10.2337/diabetes.52.1.145
Cognitive Ability and Brain Structure in Type 1 Diabetes: Relation to Microangiopathy and Preceding Severe Hypoglycemia
Stewart C. Ferguson; Annette Blane; Petros Perros; Rory J. McCrimmon; Jonathan J.K. Best; Joanna Wardlaw; Ian J. Deary; Brian M. Frier
View articletitled, Cognitive Ability and Brain Structure in Type 1 Diabetes<span class="subtitle-colon">: </span><span class="subtitle">Relation to Microangiopathy and Preceding Severe Hypoglycemia</span>
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Diabetes January 2003, Vol.52, 149-156. doi:https://doi.org/10.2337/diabetes.52.1.149

Complications

The Effectiveness of Treatments of Diabetic Autonomic Neuropathy Is Not the Same in Autonomic Nerves Supplying Different Organs
Hannah R. Shotton; Simon Clarke; Jill Lincoln
View articletitled, The Effectiveness of Treatments of Diabetic Autonomic Neuropathy Is Not the Same in Autonomic Nerves Supplying Different Organs
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Diabetes January 2003, Vol.52, 157-164. doi:https://doi.org/10.2337/diabetes.52.1.157
Oxidative Injury and Apoptosis of Dorsal Root Ganglion Neurons in Chronic Experimental Diabetic Neuropathy
Ann M. Schmeichel; James D. Schmelzer; Phillip A. Low
View articletitled, Oxidative Injury and Apoptosis of Dorsal Root Ganglion Neurons in Chronic Experimental Diabetic Neuropathy
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Diabetes January 2003, Vol.52, 165-171. doi:https://doi.org/10.2337/diabetes.52.1.165
The Atherogenic Lipoprotein Profile Associated With Obesity and Insulin Resistance Is Largely Attributable to Intra-Abdominal Fat
Delma J. Nieves; Miriam Cnop; Barbara Retzlaff; Carolyn E. Walden; John D. Brunzell; Robert H. Knopp; Steven E. Kahn
View articletitled, The Atherogenic Lipoprotein Profile Associated With Obesity and Insulin Resistance Is Largely Attributable to Intra-Abdominal Fat
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Diabetes January 2003, Vol.52, 172-179. doi:https://doi.org/10.2337/diabetes.52.1.172

Genetics

Combinations of Nondiabetic Parental Genomes Elicit Impaired Glucose Tolerance in Mouse SMXA Recombinant Inbred Strains
Misato Kobayashi; Tamio Ohno; Atsushi Tsuji; Masahiko Nishimura; Fumihiko Horio
View articletitled, Combinations of Nondiabetic Parental Genomes Elicit Impaired Glucose Tolerance in Mouse SMXA Recombinant Inbred Strains
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Diabetes January 2003, Vol.52, 180-186. doi:https://doi.org/10.2337/diabetes.52.1.180
The Insulin Gene Variable Number Tandem Repeat Class I/III Polymorphism Is in Linkage Disequilibrium With Birth Weight but Not Type 2 Diabetes in the Pima Population
Robert S. Lindsay; Robert L. Hanson; Chris Wiedrich; William C. Knowler; Peter H. Bennett; Leslie J. Baier
View articletitled, The Insulin Gene Variable Number Tandem Repeat Class I/III Polymorphism Is in Linkage Disequilibrium With Birth Weight but Not Type 2 Diabetes in the Pima Population
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Diabetes January 2003, Vol.52, 187-193. doi:https://doi.org/10.2337/diabetes.52.1.187
Impact of Two Common Polymorphisms in the PPARγ Gene on Glucose Tolerance and Plasma Insulin Profiles in Monozygotic and Dizygotic Twins: Thrifty Genotype, Thrifty Phenotype, or Both?
Pernille Poulsen; Gitte Andersen; Mogens Fenger; Torben Hansen; Søren M. Echwald; Aage Vølund; Henning Beck-Nielsen; Oluf Pedersen; Allan Vaag
View articletitled, Impact of Two Common Polymorphisms in the <em>PPARγ</em> Gene on Glucose Tolerance and Plasma Insulin Profiles in Monozygotic and Dizygotic Twins<span class="subtitle-colon">: </span><span class="subtitle">Thrifty Genotype, Thrifty Phenotype, or Both?</span>
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Diabetes January 2003, Vol.52, 194-198. doi:https://doi.org/10.2337/diabetes.52.1.194
Physical Exercise-Induced Hyperinsulinemic Hypoglycemia Is an Autosomal-Dominant Trait Characterized by Abnormal Pyruvate-Induced Insulin Release
Timo Otonkoski; Nina Kaminen; Jarkko Ustinov; Risto Lapatto; Thomas Meissner; Ertan Mayatepek; Juha Kere; Ilkka Sipilä
View articletitled, Physical Exercise-Induced Hyperinsulinemic Hypoglycemia Is an Autosomal-Dominant Trait Characterized by Abnormal Pyruvate-Induced Insulin Release
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Diabetes January 2003, Vol.52, 199-204. doi:https://doi.org/10.2337/diabetes.52.1.199

Brief Genetics Reports

The Derivation of Highly Germline-Competent Embryonic Stem Cells Containing NOD-Derived Genome
Frances A. Brook; Edward P. Evans; Christopher J. Lord; Paul A. Lyons; Daniel B. Rainbow; Sarah K. Howlett; Linda S. Wicker; John A. Todd; Richard L. Gardner
View articletitled, The Derivation of Highly Germline-Competent Embryonic Stem Cells Containing NOD-Derived Genome
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Diabetes January 2003, Vol.52, 205-208. doi:https://doi.org/10.2337/diabetes.52.1.205
Mapping Genes Influencing Type 2 Diabetes Risk and BMI in Japanese Subjects
Naoko Iwasaki; Nancy J. Cox; Yan-Qing Wang; Peter E.H. Schwarz; Graeme I. Bell; Masashi Honda; Mitsuo Imura; Makiko Ogata; Masayuki Saito; Naoyuki Kamatani; Yasuhiko Iwamoto
View articletitled, Mapping Genes Influencing Type 2 Diabetes Risk and BMI in Japanese Subjects
Supplementary data
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Diabetes January 2003, Vol.52, 209-213. doi:https://doi.org/10.2337/diabetes.52.1.209
Variation in Resistin Gene Promoter Not Associated With Polycystic Ovary Syndrome
Margrit Urbanek; Yangzhu Du; Kaisa Silander; Francis S. Collins; Claire M. Steppan; Jerome F. Strauss, III; Andrea Dunaif; Richard S. Spielman; Richard S. Legro
View articletitled, Variation in Resistin Gene Promoter Not Associated With Polycystic Ovary Syndrome
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Diabetes January 2003, Vol.52, 214-217. doi:https://doi.org/10.2337/diabetes.52.1.214
A Susceptibility Allele From a Non-Diabetes-Prone Mouse Strain Accelerates Diabetes in NOD Congenic Mice
Thomas C. Brodnicki; Fiona Quirk; Grant Morahan
View articletitled, A Susceptibility Allele From a Non-Diabetes-Prone Mouse Strain Accelerates Diabetes in NOD Congenic Mice
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Diabetes January 2003, Vol.52, 218-222. doi:https://doi.org/10.2337/diabetes.52.1.218

Erratum

Errata
View articletitled, Errata
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Diabetes January 2003, Vol.52, 223-224. doi:https://doi.org/10.2337/diabetes.52.1.223
Système International (SI) Units Table
Management of Latent Autoimmune Diabetes in Adults: A Consensus Statement From an International Expert Panel
713-P: Is There a Correct Time to Measure Fasting Blood Sugar in Persons with Type 2 Diabetes Melitus?
300-OR: Beneficial Effect of the Combination Therapy of Cagrilintide, a Dual Amylin/Calcitonin Agonist, and Tirzepatide, a Dual GLP-1/GIP Agonist, on Body Weight Loss in Obese Rats
Elevated First-Trimester Neutrophil Count Is Closely Associated With the Development of Maternal Gestational Diabetes Mellitus and Adverse Pregnancy Outcomes
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