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Metabolism

Primacy of Hepatic Insulin Resistance in the Development of the Metabolic Syndrome Induced by an Isocaloric Moderate-Fat Diet in the Dog

Stella P. Kim; Martin Ellmerer; Gregg W. Van Citters; Richard N. Bergman

Abstract

View articletitled, Primacy of Hepatic Insulin Resistance in the Development of the Metabolic Syndrome Induced by an Isocaloric Moderate-Fat Diet in the Dog

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Topics: diet , dog, domestic , glucose , insulin , insulin resistance

Diabetes October 2003, Vol.52, 2453-2460. doi:https://doi.org/10.2337/diabetes.52.10.2453

A Sustained Increase in Plasma Free Fatty Acids Impairs Insulin Secretion in Nondiabetic Subjects Genetically Predisposed to Develop Type 2 Diabetes

Sangeeta Kashyap; Renata Belfort; Amalia Gastaldelli; Thongchai Pratipanawatr; Rachele Berria; Wilailak Pratipanawatr; Mandeep Bajaj; Lawrence Mandarino; Ralph DeFronzo; Kenneth Cusi

Abstract

View articletitled, A Sustained Increase in Plasma Free Fatty Acids Impairs Insulin Secretion in Nondiabetic Subjects Genetically Predisposed to Develop Type 2 Diabetes

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Topics: glucose , hyperglycemic agents , infusion procedures , insulin , lipids

Diabetes October 2003, Vol.52, 2461-2474. doi:https://doi.org/10.2337/diabetes.52.10.2461

Measurement of Fractional Whole-Body Gluconeogenesis in Humans From Blood Samples Using ²H Nuclear Magnetic Resonance Spectroscopy

O. Kunert; H. Stingl; E. Rosian; M. Krššák; E. Bernroider; W. Seebacher; K. Zangger; P. Staehr; V. Chandramouli; B.R. Landau; P. Nowotny; W. Waldhäusl; E. Haslinger; M. Roden

Abstracts

View articletitled, Measurement of Fractional Whole-Body Gluconeogenesis in Humans From Blood Samples Using 2H Nuclear Magnetic Resonance Spectroscopy

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Topics: fasting , galactose , gluconeogenesis , glucose , spectrum analysis

Diabetes October 2003, Vol.52, 2475-2482. doi:https://doi.org/10.2337/diabetes.52.10.2475

Signal Transduction

Insulin Resistance in the Liver-Specific IGF-1 Gene-Deleted Mouse Is Abrogated by Deletion of the Acid-Labile Subunit of the IGF-Binding Protein-3 Complex: Relative Roles of Growth Hormone and IGF-1 in Insulin Resistance

Martin Haluzik; Shoshana Yakar; Oksana Gavrilova; Jennifer Setser; Yves Boisclair; Derek LeRoith

Abstract

View articletitled, Insulin Resistance in the Liver-Specific IGF-1 Gene-Deleted Mouse Is Abrogated by Deletion of the Acid-Labile Subunit of the IGF-Binding Protein-3 Complex: Relative Roles of Growth Hormone and IGF-1 in Insulin Resistance

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Topics: insulin resistance , insulin-like growth factor i , liver , mice , somatotropin

Diabetes October 2003, Vol.52, 2483-2489. doi:https://doi.org/10.2337/diabetes.52.10.2483

Obesity Studies

Insulin Sensitivity, Insulin Secretion, and Abdominal Fat: The Insulin Resistance Atherosclerosis Study (IRAS) Family Study

Lynne E. Wagenknecht; Carl D. Langefeld; Ann L. Scherzinger; Jill M. Norris; Steven M. Haffner; Mohammed F. Saad; Richard N. Bergman

Abstract

View articletitled, Insulin Sensitivity, Insulin Secretion, and Abdominal Fat: The Insulin Resistance Atherosclerosis Study (IRAS) Family Study

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Topics: abdomen , atherosclerosis , insulin , insulin resistance , insulin secretion

Diabetes October 2003, Vol.52, 2490-2496. doi:https://doi.org/10.2337/diabetes.52.10.2490

Immunology and Transplantation

Variations in IB1/JIP1 Expression Regulate Susceptibility of β-Cells to Cytokine-Induced Apoptosis Irrespective of C-Jun NH₂-Terminal Kinase Signaling

Zhidong Ling; Mark Van de Casteele; Jing Dong; Harry Heimberg; Jacques-Antoine Haefliger; Gérard Waeber; Frans Schuit; Daniel Pipeleers

Abstracts

View articletitled, Variations in IB1/JIP1 Expression Regulate Susceptibility of β-Cells to Cytokine-Induced Apoptosis Irrespective of C-Jun NH2-Terminal Kinase Signaling

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Topics: apoptosis , cytokine , tumor necrosis factors , signal transduction

Diabetes October 2003, Vol.52, 2497-2502. doi:https://doi.org/10.2337/diabetes.52.10.2497

Islet Studies

Nestin-Lineage Cells Contribute to the Microvasculature but Not Endocrine Cells of the Islet

Mary Kay Treutelaar; Jennifer M. Skidmore; Claudia L. Dias-Leme; Manami Hara; Lizhi Zhang; Diane Simeone; Donna M. Martin; Charles F. Burant

Abstract

View articletitled, Nestin-Lineage Cells Contribute to the Microvasculature but Not Endocrine Cells of the Islet

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Topics: endocrine cells , insulin , mice , nestin protein , pancreas

Diabetes October 2003, Vol.52, 2503-2512. doi:https://doi.org/10.2337/diabetes.52.10.2503

NN414, a SUR1/Kir6.2-Selective Potassium Channel Opener, Reduces Blood Glucose and Improves Glucose Tolerance in the VDF Zucker Rat

Richard D. Carr; Christian L. Brand; Thora B. Bodvarsdottir; John B. Hansen; Jeppe Sturis

Abstracts

View articletitled, NN414, a SUR1/Kir6.2-Selective Potassium Channel Opener, Reduces Blood Glucose and Improves Glucose Tolerance in the VDF Zucker Rat

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Topics: blood glucose , glucose , insulin , oral glucose tolerance test , pancreas

Diabetes October 2003, Vol.52, 2513-2518. doi:https://doi.org/10.2337/diabetes.52.10.2513

Characterization and Isolation of Promoter-Defined Nestin-Positive Cells from the Human Fetal Pancreas

Rohan K. Humphrey; Nathan Bucay; Gillian M. Beattie; Ana Lopez; Conrad A. Messam; Vincenzo Cirulli; Alberto Hayek

Abstract

View articletitled, Characterization and Isolation of Promoter-Defined Nestin-Positive Cells from the Human Fetal Pancreas

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Topics: fetus , nestin protein , pancreas , transplantation

Diabetes October 2003, Vol.52, 2519-2525. doi:https://doi.org/10.2337/diabetes.52.10.2519

Sulfonylureas Rapidly Cross Phospholipid Bilayer Membranes by a Free-Diffusion Mechanism

Frits Kamp; Nadeem Kizilbash; Barbara E. Corkey; Per-Olof Berggren; James A. Hamilton

Abstracts

View articletitled, Sulfonylureas Rapidly Cross Phospholipid Bilayer Membranes by a Free-Diffusion Mechanism

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Topics: glyburide , phospholipids , prekallikrein , sulfonylurea compounds , tissue membrane

Diabetes October 2003, Vol.52, 2526-2531. doi:https://doi.org/10.2337/diabetes.52.10.2526

Pathophysiology

Long-Term Improvement in Insulin Sensitivity by Changing Lifestyles of People with Impaired Glucose Tolerance: 4-Year Results From the Finnish Diabetes Prevention Study

Matti Uusitupa; Virpi Lindi; Anne Louheranta; Titta Salopuro; Jaana Lindström; Jaakko Tuomilehto; for the Finnish Diabetes Prevention Study Group

Abstract

View articletitled, Long-Term Improvement in Insulin Sensitivity by Changing Lifestyles of People with Impaired Glucose Tolerance: 4-Year Results From the Finnish Diabetes Prevention Study

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Topics: deuterium , diabetes mellitus, type 2 , diabetes prevention , fasting , glucose

Diabetes October 2003, Vol.52, 2532-2538. doi:https://doi.org/10.2337/diabetes.52.10.2532

Cellular Aspects of Intestinal Lipoprotein Assembly in Psammomys Obesus: A Model of Insulin Resistance and Type 2 Diabetes

Monika Zoltowska; Ehud Ziv; Edgard Delvin; Daniel Sinnett; Ronny Kalman; Carole Garofalo; Ernest Seidman; Emile Levy

Abstract

View articletitled, Cellular Aspects of Intestinal Lipoprotein Assembly in Psammomys Obesus: A Model of Insulin Resistance and Type 2 Diabetes

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Topics: apolipoprotein b-48 , insulin resistance , intestines , lipids , lipoproteins

Diabetes October 2003, Vol.52, 2539-2545. doi:https://doi.org/10.2337/diabetes.52.10.2539

Low Plasma Ghrelin Is Associated With Insulin Resistance, Hypertension, and the Prevalence of Type 2 Diabetes

Seppo M. Pöykkö; Eija Kellokoski; Sohvi Hörkkö; Heikki Kauma; Y. Antero Kesäniemi; Olavi Ukkola

Abstract

View articletitled, Low Plasma Ghrelin Is Associated With Insulin Resistance, Hypertension, and the Prevalence of Type 2 Diabetes

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Topics: diabetes mellitus, type 2 , ghrelin , hypertension , plasma , insulin

Diabetes October 2003, Vol.52, 2546-2553. doi:https://doi.org/10.2337/diabetes.52.10.2546

Complications

Inhibition of Net HepG2 Cell Apolipoprotein B Secretion by the Citrus Flavonoid Naringenin Involves Activation of Phosphatidylinositol 3-Kinase, Independent of Insulin Receptor Substrate-1 Phosphorylation

Nica M. Borradaile; Linda E. de Dreu; Murray W. Huff

Abstract

View articletitled, Inhibition of Net HepG2 Cell Apolipoprotein B Secretion by the Citrus Flavonoid Naringenin Involves Activation of Phosphatidylinositol 3-Kinase, Independent of Insulin Receptor Substrate-1 Phosphorylation

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Topics: 1-phosphatidylinositol 3-kinase , apolipoproteins b , insulin , naringenin , phosphoinositide 3-kinase

Diabetes October 2003, Vol.52, 2554-2561. doi:https://doi.org/10.2337/diabetes.52.10.2554

Insulin Affects Vascular Smooth Muscle Cell Phenotype and Migration Via Distinct Signaling Pathways

Cecilia C. Low Wang; Inga Gurevich; Boris Draznin

Abstract

View articletitled, Insulin Affects Vascular Smooth Muscle Cell Phenotype and Migration Via Distinct Signaling Pathways

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Topics: insulin , muscle, smooth, vascular , platelet-derived growth factor , wortmannin , 1-phosphatidylinositol 3-kinase

Diabetes October 2003, Vol.52, 2562-2569. doi:https://doi.org/10.2337/diabetes.52.10.2562

Reactive Oxygen Species from Mitochondria Induce Cyclooxygenase-2 Gene Expression in Human Mesangial Cells: Potential Role in Diabetic Nephropathy

Shinsuke Kiritoshi; Takeshi Nishikawa; Kazuhiro Sonoda; Daisuke Kukidome; Takahumi Senokuchi; Tomoko Matsuo; Takeshi Matsumura; Hiroshi Tokunaga; Michael Brownlee; Eiichi Araki

Abstract

View articletitled, Reactive Oxygen Species from Mitochondria Induce Cyclooxygenase-2 Gene Expression in Human Mesangial Cells: Potential Role in Diabetic Nephropathy

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Topics: cyclooxygenase-2 , glucose , kaufman-mckusick syndrome , mitochondria , rna, messenger

Diabetes October 2003, Vol.52, 2570-2577. doi:https://doi.org/10.2337/diabetes.52.10.2570

Neuroprotective Effect of Docosahexaenoic Acid-Enriched Phospholipids in Experimental Diabetic Neuropathy

Thierry C. Coste; Alain Gerbi; Philippe Vague; Gérard Pieroni; Denis Raccah

Abstract

View articletitled, Neuroprotective Effect of Docosahexaenoic Acid-Enriched Phospholipids in Experimental Diabetic Neuropathy

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Topics: adenosine triphosphatases , diabetic neuropathies , erythrocytes , fatty acids , phospholipids

Diabetes October 2003, Vol.52, 2578-2585. doi:https://doi.org/10.2337/diabetes.52.10.2578

Intercellular Adhesion Molecule-1–Deficient Mice Are Resistant Against Renal Injury After Induction of Diabetes

Shinichi Okada; Kenichi Shikata; Mitsuhiro Matsuda; Daisuke Ogawa; Hitomi Usui; Yuichi Kido; Ryo Nagase; Jun Wada; Yasushi Shikata; Hirofumi Makino

Abstract

View articletitled, Intercellular Adhesion Molecule-1–Deficient Mice Are Resistant Against Renal Injury After Induction of Diabetes

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Topics: intercellular adhesion molecule 1 , mice , kidney , collagen type iv , kidney glomerulus

Diabetes October 2003, Vol.52, 2586-2593. doi:https://doi.org/10.2337/diabetes.52.10.2586

Glucose Induces Clonal Selection and Reversible Dinucleotide Repeat Expansion in Mesangial Cells Isolated from Glomerulosclerosis-Prone Mice

Alessia Fornoni; Oliver Lenz; Liliane J. Striker; Gary E. Striker

Abstracts

View articletitled, Glucose Induces Clonal Selection and Reversible Dinucleotide Repeat Expansion in Mesangial Cells Isolated from Glomerulosclerosis-Prone Mice

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Topics: clone cells , gelatinase b , glucose , mesangial cells , mice

Diabetes October 2003, Vol.52, 2594-2602. doi:https://doi.org/10.2337/diabetes.52.10.2594

Translocation of Glomerular p47phox and p67phox by Protein Kinase C-β Activation Is Required for Oxidative Stress in Diabetic Nephropathy

Munehiro Kitada; Daisuke Koya; Toshiro Sugimoto; Motohide Isono; Shin-ichi Araki; Atsunori Kashiwagi; Masakazu Haneda

Abstract

View articletitled, Translocation of Glomerular p47phox and p67phox by Protein Kinase C-β Activation Is Required for Oxidative Stress in Diabetic Nephropathy

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Topics: kidney glomerulus , nadph oxidases , ncf1 gene , ncf2 gene , translocation (genetics)

Diabetes October 2003, Vol.52, 2603-2614. doi:https://doi.org/10.2337/diabetes.52.10.2603

Endoneurial Capillary Abnormalities Presage Deterioration of Glucose Tolerance and Accompany Peripheral Neuropathy in Man

Soley Thrainsdottir; Rayez A. Malik; Lars B. Dahlin; Peter Wiksell; Karl F. Eriksson; Ingmar Rosén; Jesper Petersson; Douglas A. Greene; Göran Sundkvist

Abstract

View articletitled, Endoneurial Capillary Abnormalities Presage Deterioration of Glucose Tolerance and Accompany Peripheral Neuropathy in Man

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Topics: blood capillaries , follow-up , glucose tolerance , neuropathy , peripheral neuropathy

Diabetes October 2003, Vol.52, 2615-2622. doi:https://doi.org/10.2337/diabetes.52.10.2615

Relationship of Family History of Type 2 Diabetes, Hypoglycemia, and Autoantibodies to Weight Gain and Lipids With Intensive and Conventional Therapy in the Diabetes Control and Complications Trial

Jonathan Q. Purnell; Raj K. Dev; Michael W. Steffes; Patricia A. Cleary; Jerry P. Palmer; Irl B. Hirsch; John E. Hokanson; John D. Brunzell

Abstract

View articletitled, Relationship of Family History of Type 2 Diabetes, Hypoglycemia, and Autoantibodies to Weight Gain and Lipids With Intensive and Conventional Therapy in the Diabetes Control and Complications Trial

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Topics: dcct trial , diabetes mellitus, type 2 , hypoglycemia , weight gain , lipids

Diabetes October 2003, Vol.52, 2623-2629. doi:https://doi.org/10.2337/diabetes.52.10.2623

Brief Genetics Reports

Kir6.2 Polymorphisms Sensitize β-Cell ATP-Sensitive Potassium Channels to Activation by Acyl CoAs : A Possible Cellular Mechanism for Increased Susceptibility to Type 2 Diabetes?

Michael J. Riedel; Parveen Boora; Diana Steckley; Gerda de Vries; Peter E. Light

Abstract

View articletitled, Kir6.2 Polymorphisms Sensitize β-Cell ATP-Sensitive Potassium Channels to Activation by Acyl CoAs : A Possible Cellular Mechanism for Increased Susceptibility to Type 2 Diabetes?

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Topics: diabetes mellitus, type 2 , glucagon-like peptide 1 , katp channels , palmitoyl coenzyme a , polymorphism

Diabetes October 2003, Vol.52, 2630-2635. doi:https://doi.org/10.2337/diabetes.52.10.2630

A Novel Gene for Neonatal Diabetes Maps to Chromosome 10p12.1-p13

Gabrielle S. Sellick; Christine Garrett; Richard S. Houlston

Abstract

View articletitled, A Novel Gene for Neonatal Diabetes Maps to Chromosome 10p12.1-p13

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Topics: chromosomes , genes , neonatal diabetes mellitus , single nucleotide polymorphism , maps

Diabetes October 2003, Vol.52, 2636-2638. doi:https://doi.org/10.2337/diabetes.52.10.2636

KIR in Type 1 Diabetes : Disparate Distribution of Activating and Inhibitory Natural Killer Cell Receptors in Patients Versus HLA-Matched Control Subjects

Arno R. van der Slik; Bobby P.C. Koeleman; Willem Verduijn; G. Jan Bruining; Bart O. Roep; Marius J. Giphart

Abstracts

View articletitled, KIR in Type 1 Diabetes : Disparate Distribution of Activating and Inhibitory Natural Killer Cell Receptors in Patients Versus HLA-Matched Control Subjects

Supplementary data

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Topics: diabetes mellitus, type 1 , human leukocyte antigens , ligands , natural killer cells , genes

Diabetes October 2003, Vol.52, 2639-2642. doi:https://doi.org/10.2337/diabetes.52.10.2639

Erratum

Extract

View articletitled, Erratum

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Topics: c-peptide , diabetes mellitus, type 1 , guidelines , immunology

Diabetes October 2003, Vol.52, 2643. doi:https://doi.org/10.2337/diabetes.52.10.2643

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