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Issues
1 November 2003
ISSN 0012-1797
EISSN 1939-327X
Rapid Publication
Identification of a β-Cell-Specific HLA Class I Restricted Epitope in Type 1 Diabetes
Topics:
diabetes mellitus, type 1
,
epitopes
,
human leukocyte antigens
,
peptides
,
hla-a2 antigen
Diabetes November 2003, Vol.52, 2647-2651. doi:https://doi.org/10.2337/diabetes.52.11.2647
Perspectives in Diabetes
Hypothesis: Shifting the Equilibrium From Activity to Food Leads to Autonomic Unbalance and the Metabolic Syndrome
Felix Kreier; Ajda Yilmaz; Andries Kalsbeek; Johannes A. Romijn; Hans P. Sauerwein; Eric Fliers; Ruud M. Buijs
Topics:
autonomic nervous system
,
metabolic syndrome x
,
brain
Diabetes November 2003, Vol.52, 2652-2656. doi:https://doi.org/10.2337/diabetes.52.11.2652
Signal Transduction
Increased Insulin Sensitivity and Hypoinsulinemia in APS Knockout Mice
Asako Minami; Masanori Iseki; Kazuhiro Kishi; Miao Wang; Makoto Ogura; Noboru Furukawa; Sanae Hayashi; Mizuki Yamada; Toshiyuki Obata; Yukari Takeshita; Yutaka Nakaya; Yoshimi Bando; Keisuke Izumi; Shonna A. Moodie; Fumiko Kajiura; Mitsuru Matsumoto; Kiyoshi Takatsu; Satoshi Takaki; Yousuke Ebina
Topics:
insulin
,
mice
,
insulin receptor
,
insulin sensitivity
,
adipocytes
Diabetes November 2003, Vol.52, 2657-2665. doi:https://doi.org/10.2337/diabetes.52.11.2657
Obesity Study
Coordinated Upregulation of Oxidative Pathways and Downregulation of Lipid Biosynthesis Underlie Obesity Resistance in Perilipin Knockout Mice: A Microarray Gene Expression Profile
Fernando Castro-Chavez; Vijay K. Yechoor; Pradip K. Saha; Javier Martinez-Botas; Eric C. Wooten; Saumya Sharma; Peter O’Connell; Heinrich Taegtmeyer; Lawrence Chan
Topics:
genes
,
mice
,
obesity
,
perilipin
,
down-regulation
Diabetes November 2003, Vol.52, 2666-2674. doi:https://doi.org/10.2337/diabetes.52.11.2666
Transgenic Neuronal Expression of Proopiomelanocortin Attenuates Hyperphagic Response to Fasting and Reverses Metabolic Impairments in Leptin-Deficient Obese Mice
Topics:
leptin
,
mice
,
pro-opiomelanocortin
,
transgenes
Diabetes November 2003, Vol.52, 2675-2683. doi:https://doi.org/10.2337/diabetes.52.11.2675
Learned Meal Initiation Attenuates the Anorexic Effects of the Melanocortin Agonist MTII
Topics:
agonists
,
appetite depressants
,
diet
,
eating
,
obesity
Diabetes November 2003, Vol.52, 2684-2688. doi:https://doi.org/10.2337/diabetes.52.11.2684
Immunology and Transplantation
Recombinant Fabs of Human Monoclonal Antibodies Specific to the Middle Epitope of GAD65 Inhibit Type 1 Diabetes–Specific GAD65Abs
Carolyn J. Padoa; J. Paul Banga; Anne-Marie Madec; Manfred Ziegler; Michael Schlosser; Eva Ortqvist; Ingrid Kockum; Jerry Palmer; Olov Rolandsson; Katherine A. Binder; Jefferson Foote; Dong Luo; Christiane S. Hampe
Topics:
diabetes mellitus, type 1
,
epitopes
,
monoclonal antibodies
,
serum
,
fusion proteins
Diabetes November 2003, Vol.52, 2689-2695. doi:https://doi.org/10.2337/diabetes.52.11.2689
Target Cell Expression of Suppressor of Cytokine Signaling-1 Prevents Diabetes in the NOD Mouse
Malin Flodström-Tullberg; Deepak Yadav; Robert Hägerkvist; Devin Tsai; Patrick Secrest; Alexandr Stotland; Nora Sarvetnick
Topics:
cytokine
,
mice
,
mice, inbred nod
,
signal transduction
,
suppressor of cytokine signaling 1 protein
Diabetes November 2003, Vol.52, 2696-2700. doi:https://doi.org/10.2337/diabetes.52.11.2696
Discovery of Gene Networks Regulating Cytokine-Induced Dysfunction and Apoptosis in Insulin-Producing INS-1 Cells
Burak Kutlu; Alessandra K. Cardozo; Martine I. Darville; Mogens Kruhøffer; Nils Magnusson; Torben Ørntoft; Décio L. Eizirik
Topics:
apoptosis
,
cytokine
,
genes
,
insulin
,
nitric oxide synthase
Diabetes November 2003, Vol.52, 2701-2719. doi:https://doi.org/10.2337/diabetes.52.11.2701
Islet Study
Parathyroid Hormone–Related Protein Induces Insulin Expression Through Activation of MAP Kinase–Specific Phosphatase-1 That Dephosphorylates c-Jun NH2-Terminal Kinase in Pancreatic β-Cells
Bin Zhang; Masahiro Hosaka; Yoshie Sawada; Seiji Torii; Shin Mizutani; Masato Ogata; Tetsuro Izumi; Toshiyuki Takeuchi
Topics:
insulin
,
parathyroid hormone-related protein
,
phosphotransferases
,
mitogen-activated protein kinases
,
rna, messenger
Diabetes November 2003, Vol.52, 2720-2730. doi:https://doi.org/10.2337/diabetes.52.11.2720
Rapamycin Has a Deleterious Effect on MIN-6 Cells and Rat and Human Islets
Ewan Bell; Xiaopei Cao; Jacob A. Moibi; Scott R. Greene; Robert Young; Matteo Trucco; Zhiyong Gao; Franz M. Matschinsky; Shaoping Deng; James F. Markman; Ali Naji; Bryan A. Wolf
Topics:
rapamycin
,
cell survival
Diabetes November 2003, Vol.52, 2731-2739. doi:https://doi.org/10.2337/diabetes.52.11.2731
Pathophysiology
Identification of Subjects with Insulin Resistance and β-Cell Dysfunction Using Alternative Definitions of the Metabolic Syndrome
Anthony J.G. Hanley; Lynne E. Wagenknecht; Ralph B. D’Agostino, Jr.; Bernard Zinman; Steven M. Haffner
Topics:
cardiovascular diseases
,
insulin
,
insulin resistance
,
metabolic syndrome x
,
world health organization
Diabetes November 2003, Vol.52, 2740-2747. doi:https://doi.org/10.2337/diabetes.52.11.2740
Contribution of Elevated Free Fatty Acid Levels to the Lack of Glucose Effectiveness in Type 2 Diabetes
Meredith Hawkins; Julia Tonelli; Preeti Kishore; Daniel Stein; Enzo Ragucci; Alon Gitig; Kalpana Reddy
Topics:
diabetes mellitus, type 2
,
glucose
,
hyperglycemia
,
infusion procedures
,
insulin
Diabetes November 2003, Vol.52, 2748-2758. doi:https://doi.org/10.2337/diabetes.52.11.2748
Prevalence and Clinicopathological Characteristics of Islet Amyloid in Chinese Patients With Type 2 Diabetes
Hai-Lu Zhao; Fernand M.M. Lai; Peter C.Y. Tong; Ding-Rong Zhong; Di Yang; Brian Tomlinson; Juliana C.N. Chan
Topics:
amyloid
,
diabetes mellitus, type 2
Diabetes November 2003, Vol.52, 2759-2766. doi:https://doi.org/10.2337/diabetes.52.11.2759
Extracellular Glucose in Rat Ventromedial Hypothalamus During Acute and Recurrent Hypoglycemia
Topics:
glucose
,
hypoglycemia
,
rats
,
blood glucose
Diabetes November 2003, Vol.52, 2767-2773. doi:https://doi.org/10.2337/diabetes.52.11.2767
Counterregulatory Hormone and Symptom Responses to Insulin-Induced Hypoglycemia in the Postprandial State in Humans
Francesca Porcellati; Simone Pampanelli; Paolo Rossetti; Cristina Cordoni; Stefania Marzotti; Luciano Scionti; Geremia B. Bolli; Carmine G. Fanelli
Topics:
epinephrine
,
fasting
,
glucagon
,
hormones
,
hypoglycemia
Diabetes November 2003, Vol.52, 2774-2783. doi:https://doi.org/10.2337/diabetes.52.11.2774
Chronic Exposure to Interleukin-6 Causes Hepatic Insulin Resistance in Mice
Topics:
insulin
,
interleukin-6
,
mice
,
insulin receptor
,
liver
Diabetes November 2003, Vol.52, 2784-2789. doi:https://doi.org/10.2337/diabetes.52.11.2784
Timing of Changes in Interstitial and Venous Blood Glucose Measured With a Continuous Subcutaneous Glucose Sensor
Topics:
blood glucose
,
glucose
,
sensor
Diabetes November 2003, Vol.52, 2790-2794. doi:https://doi.org/10.2337/diabetes.52.11.2790
Complications
Intermittent High Glucose Enhances Apoptosis Related to Oxidative Stress in Human Umbilical Vein Endothelial Cells : The Role of Protein Kinase C and NAD(P)H-Oxidase Activation
Topics:
3-nitrotyrosine
,
apoptosis
,
endothelial cells
,
glucose
,
oxidase
Diabetes November 2003, Vol.52, 2795-2804. doi:https://doi.org/10.2337/diabetes.52.11.2795
Adverse Effects of Dietary Glycotoxins on Wound Healing in Genetically Diabetic Mice
Melpomeni Peppa; Harold Brem; Paul Ehrlich; Jian-Gang Zhang; Weijing Cai; Zhu Li; Anca Croitoru; Swan Thung; Helen Vlassara
Topics:
diet
,
mice
,
skin
,
wound closure
Diabetes November 2003, Vol.52, 2805-2813. doi:https://doi.org/10.2337/diabetes.52.11.2805
Influence of Type 2 Diabetes on Functional and Structural Properties of Coronary Artery Bypass Conduits
Roberto Lorusso; Samuele Pentiricci; Riccardo Raddino; Tiziano M. Scarabelli; Claudia Zambelli; Vincenzo Villanacci; Anna Burattin; Giuseppe Romanelli; Salvatore Casari; Roberto Scelsi; Andrea Giustina
Topics:
conduit implant
,
coronary artery bypass surgery
,
tissue transplants
,
diabetes mellitus, type 2
,
preoperative care
Diabetes November 2003, Vol.52, 2814-2820. doi:https://doi.org/10.2337/diabetes.52.11.2814
Leptin and Wound Inflammation in Diabetic ob/ob Mice: Differential Regulation of Neutrophil and Macrophage Influx and a Potential Role for the Scab as a Sink for Inflammatory Cells and Mediators
Topics:
leptin
,
macrophages
,
mice
,
scab
Diabetes November 2003, Vol.52, 2821-2832. doi:https://doi.org/10.2337/diabetes.52.11.2821
Effect of Type 1 Diabetes on the Gender Difference in Coronary Artery Calcification: a Role for Insulin Resistance? : The Coronary Artery Calcification in Type 1 Diabetes (CACTI) Study
Dana Dabelea; Gregory Kinney; Janet K. Snell-Bergeon; John E. Hokanson; Robert H. Eckel; James Ehrlich; Satish Garg; Richard F. Hamman; Marian Rewers
Topics:
coronary arteriosclerosis
,
coronary artery calcium
,
diabetes mellitus, type 1
,
insulin resistance
,
gender differences
Diabetes November 2003, Vol.52, 2833-2839. doi:https://doi.org/10.2337/diabetes.52.11.2833
Genetics
Linkage Analysis of a Composite Factor for the Multiple Metabolic Syndrome: The National Heart, Lung, and Blood Institute Family Heart Study
Weihong Tang; Michael B. Miller; Stephen S. Rich; Kari E. North; James S. Pankow; Ingrid B. Borecki; Richard H. Myers; Paul N. Hopkins; Mark Leppert; Donna K. Arnett
Topics:
body mass index procedure
,
chromosomes, human, pair 2
,
genetic linkage analysis
,
genotype determination
,
heart
Diabetes November 2003, Vol.52, 2840-2847. doi:https://doi.org/10.2337/diabetes.52.11.2840
Association of Solute Carrier Family 12 (Sodium/Chloride) Member 3 With Diabetic Nephropathy, Identified by Genome-Wide Analyses of Single Nucleotide Polymorphisms
Nobue Tanaka; Tetsuya Babazono; Susumu Saito; Akihiro Sekine; Tatsuhiko Tsunoda; Masakazu Haneda; Yasushi Tanaka; Tomoaki Fujioka; Kohei Kaku; Ryuzou Kawamori; Ryuichi Kikkawa; Yasuhiko Iwamoto; Yusuke Nakamura; Shiro Maeda
Topics:
diabetic nephropathy
,
genes
,
genotype determination
,
single nucleotide polymorphism
,
solutes
Diabetes November 2003, Vol.52, 2848-2853. doi:https://doi.org/10.2337/diabetes.52.11.2848
Permanent Neonatal Diabetes Caused by Glucokinase Deficiency: Inborn Error of the Glucose-Insulin Signaling Pathway
Pål R. Njølstad; Jørn V. Sagen; Lise Bjørkhaug; Stella Odili; Naim Shehadeh; Doua Bakry; S. Umit Sarici; Faruk Alpay; Janne Molnes; Anders Molven; Oddmund Søvik; Franz M. Matschinsky
Topics:
glucokinase
,
glucose
,
insulin
,
neonatal diabetes mellitus
,
mutation
Diabetes November 2003, Vol.52, 2854-2860. doi:https://doi.org/10.2337/diabetes.52.11.2854
Brief Genetics Report
The Endotoxin Receptor TLR4 Polymorphism Is Not Associated With Diabetes or Components of the Metabolic Syndrome
Thomas Illig; Friedhelm Bongardt; Andreas Schöpfer; Rolf Holle; Sylvia Müller; Wolfgang Rathmann; Wolfgang Koenig; Christa Meisinger; H.-Erich Wichmann; Hubert Kolb; For The KORA Study Group
Topics:
endotoxins
,
metabolic syndrome x
,
polymorphism
,
toll-like receptor 4
,
c-reactive protein
Diabetes November 2003, Vol.52, 2861-2864. doi:https://doi.org/10.2337/diabetes.52.11.2861
