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Issues
1 February 2003
ISSN 0012-1797
EISSN 1939-327X
Rapid Publications
Insulin Activation of Phosphatidylinositol 3-Kinase in the Hypothalamic Arcuate Nucleus: A Key Mediator of Insulin-Induced Anorexia
Kevin D. Niswender; Christopher D. Morrison; Deborah J. Clegg; Ryan Olson; Denis G. Baskin; Martin G. Myers, Jr.; Randy J. Seeley; Michael W. Schwartz
Topics:
1-phosphatidylinositol 3-kinase
,
hypothalamus
,
insulin
,
nucleus infundibularis hypothalami
,
loss of appetite
Diabetes February 2003, Vol.52, 227-231. doi:https://doi.org/10.2337/diabetes.52.2.227
Perspectives in Diabetes
Is the Energy Homeostasis System Inherently Biased Toward Weight Gain?
Michael W. Schwartz; Stephen C. Woods; Randy J. Seeley; Gregory S. Barsh; Denis G. Baskin; Rudolph L. Leibel
Topics:
agouti-related protein
,
homeostasis
,
leptin
,
neuropeptide y
,
obesity
Diabetes February 2003, Vol.52, 232-238. doi:https://doi.org/10.2337/diabetes.52.2.232
Metabolism and Signal Transduction
Plasma Adiponectin Concentrations Predict Insulin Sensitivity of Both Glucose and Lipid Metabolism
Otto Tschritter; Andreas Fritsche; Claus Thamer; Michael Haap; Fatemeh Shirkavand; Stefanie Rahe; Harald Staiger; Elke Maerker; Hans Häring; Michael Stumvoll
Topics:
adiponectin
,
glucose
,
insulin
,
insulin sensitivity
,
oral glucose tolerance test
Diabetes February 2003, Vol.52, 239-243. doi:https://doi.org/10.2337/diabetes.52.2.239
Increased Intramyocellular Lipid Concentration Identifies Impaired Glucose Metabolism in Women With Previous Gestational Diabetes
Alexandra Kautzky-Willer; Martin Krssak; Christine Winzer; Giovanni Pacini; Andrea Tura; Serdar Farhan; Oswald Wagner; Georg Brabant; Rüdiger Horn; Harald Stingl; Barbara Schneider; Werner Waldhäusl; Michael Roden
Topics:
body mass index procedure
,
gestational diabetes
,
glucose
,
glucose metabolism
,
insulin
Diabetes February 2003, Vol.52, 244-251. doi:https://doi.org/10.2337/diabetes.52.2.244
Role of Leptin in the Regulation of Glucagon-Like Peptide-1 Secretion
Topics:
bodily secretions
,
glucagon-like peptide 1
,
leptin
Diabetes February 2003, Vol.52, 252-259. doi:https://doi.org/10.2337/diabetes.52.2.252
Effects of Free Fatty Acids Per Se on Glucose Production, Gluconeogenesis, and Glycogenolysis
Peter Staehr; Ole Hother-Nielsen; Bernard R. Landau; Visvanathan Chandramouli; Jens Juul Holst; Henning Beck-Nielsen
Topics:
glucose
,
hyperglycemic agents
,
gluconeogenesis
,
lipids
,
glycogenolysis
Diabetes February 2003, Vol.52, 260-267. doi:https://doi.org/10.2337/diabetes.52.2.260
Obesity Studies
Sexual Differentiation, Pregnancy, Calorie Restriction, and Aging Affect the Adipocyte-Specific Secretory Protein Adiponectin
Terry P. Combs; Anders H. Berg; Michael W. Rajala; Simon Klebanov; Puneeth Iyengar; José C. Jimenez-Chillaron; Mary Elizabeth Patti; Sabra L. Klein; Robert S. Weinstein; Philipp E. Scherer
Topics:
adipocytes
,
adiponectin
,
aging
,
calorie restricted diet
,
mice
Diabetes February 2003, Vol.52, 268-276. doi:https://doi.org/10.2337/diabetes.52.2.268
Leptin Receptor−Deficient Obese Zucker Rats Reduce Their Food Intake in Response to a Systemic Supply of Calories From Glucose
Topics:
calories
,
eating
,
glucose
,
infusion procedures
,
insulin
Diabetes February 2003, Vol.52, 277-282. doi:https://doi.org/10.2337/diabetes.52.2.277
Differential Effects of Rosiglitazone and Metformin on Adipose Tissue Distribution and Glucose Uptake in Type 2 Diabetic Subjects
Kirsi A. Virtanen; Kirsti Hällsten; Riitta Parkkola; Tuula Janatuinen; Fredrik Lönnqvist; Tapio Viljanen; Tapani Rönnemaa; Juhani Knuuti; Risto Huupponen; Peter Lönnroth; Pirjo Nuutila
Topics:
adipose tissue
,
glucose uptake
,
insulin
,
metformin
,
rosiglitazone
Diabetes February 2003, Vol.52, 283-290. doi:https://doi.org/10.2337/diabetes.52.2.283
PPAR-γ Activation Mediates Adipose Depot−Specific Effects on Gene Expression and Lipoprotein Lipase Activity: Mechanisms for Modulation of Postprandial Lipemia and Differential Adipose Accretion
Topics:
agonists
,
diet
,
peroxisome proliferator-activated receptors
,
rats
,
refeeding syndrome
Diabetes February 2003, Vol.52, 291-299. doi:https://doi.org/10.2337/diabetes.52.2.291
Role of the Fatty Acid Binding Protein mal1 in Obesity and Insulin Resistance
Kazuhisa Maeda; K. Teoman Uysal; Liza Makowski; Cem Z. Görgün; Genichi Atsumi; Rex A. Parker; Jens Brüning; Ann Vogel Hertzel; David A. Bernlohr; Gökhan S. Hotamisligil
Topics:
fatty-acid-binding protein, adipocyte
,
mice
,
obesity
,
adipocytes
,
insulin resistance
Diabetes February 2003, Vol.52, 300-307. doi:https://doi.org/10.2337/diabetes.52.2.300
STAT5A Promotes Adipogenesis in Nonprecursor Cells and Associates With the Glucocorticoid Receptor During Adipocyte Differentiation
Topics:
adipocytes
,
glucocorticoid receptors
,
peroxisome proliferator-activated receptors
,
rna
,
stat5b gene
Diabetes February 2003, Vol.52, 308-314. doi:https://doi.org/10.2337/diabetes.52.2.308
Hyperactivity and Reduced Energy Cost of Physical Activity in Serotonin 5-HT2C Receptor Mutant Mice
Topics:
hyperkinesis
,
mice
,
serotonin
,
obesity
,
hyperactive behavior
Diabetes February 2003, Vol.52, 315-320. doi:https://doi.org/10.2337/diabetes.52.2.315
Immunology and Transplantation
NOD Congenic Mice Genetically Protected From Autoimmune Diabetes Remain Resistant to Transplantation Tolerance Induction
Todd Pearson; Thomas G. Markees; Linda S. Wicker; David V. Serreze; Laurence B. Peterson; John P. Mordes; Aldo A. Rossini; Dale L. Greiner
Topics:
allografting
,
cd40 ligand
,
lymphocyte costimulation
,
mice
,
mice, congenic
Diabetes February 2003, Vol.52, 321-326. doi:https://doi.org/10.2337/diabetes.52.2.321
T-Cell Compartments of Prediabetic NOD Mice
Topics:
mice, inbred nod
,
thymus gland
,
t-lymphocytes
,
mice
,
thymocytes
Diabetes February 2003, Vol.52, 327-334. doi:https://doi.org/10.2337/diabetes.52.2.327
Acute Shock Induced by Antigen Vaccination in NOD Mice
Lut Overbergh; Brigitte Decallonne; Dumitru D. Branisteanu; Dirk Valckx; Ahmad Kasran; Roger Bouillon; Chantal Mathieu
Topics:
antigens
,
mice
,
mice, inbred nod
,
shock
,
vaccination
Diabetes February 2003, Vol.52, 335-341. doi:https://doi.org/10.2337/diabetes.52.2.335
Accelerated Diabetes in Rat Insulin Promoter-Tumor Necrosis Factor-α Transgenic Nonobese Diabetic Mice Lacking Major Histocompatibility Class II Molecules
Topics:
animals, transgenic
,
mice
,
molecule
,
tumor necrosis factors
,
mice, inbred nod
Diabetes February 2003, Vol.52, 342-347. doi:https://doi.org/10.2337/diabetes.52.2.342
Molecular Regulation of Monocyte Chemoattractant Protein-1 Expression in Pancreatic β-Cells
Topics:
cytokine
,
monocyte chemoattractant protein-1
Diabetes February 2003, Vol.52, 348-355. doi:https://doi.org/10.2337/diabetes.52.2.348
Islet Studies
Stimulation of Insulin Secretion by Denatonium, One of the Most Bitter-Tasting Substances Known
Topics:
cyclic amp
,
glucose
,
glyburide
,
insulin
,
insulin secretion
Diabetes February 2003, Vol.52, 356-364. doi:https://doi.org/10.2337/diabetes.52.2.356
Role of Endogenous Glucagon-Like Peptide-1 in Islet Regeneration After Partial Pancreatectomy
Diva D. De León; Shaoping Deng; Reza Madani; Rexford S. Ahima; Daniel J. Drucker; Doris A. Stoffers
Topics:
glucagon-like peptide 1
,
glucagon-like peptide-1 receptor
,
glucose tolerance
,
hyperglycemia
,
mice
Diabetes February 2003, Vol.52, 365-371. doi:https://doi.org/10.2337/diabetes.52.2.365
Increased Dietary Fat Promotes Islet Amyloid Formation and β-Cell Secretory Dysfunction in a Transgenic Mouse Model of Islet Amyloid
Rebecca L. Hull; Sofianos Andrikopoulos; C. Bruce Verchere; Josep Vidal; Feng Wang; Miriam Cnop; Ronald L. Prigeon; Steven E. Kahn
Topics:
amyloid
,
diet
,
dietary fats
,
insulin
,
mice
Diabetes February 2003, Vol.52, 372-379. doi:https://doi.org/10.2337/diabetes.52.2.372
The Influence of GLP-1 on Glucose-Stimulated Insulin Secretion: Effects on β-Cell Sensitivity in Type 2 and Nondiabetic Subjects
Topics:
glucagon-like peptide 1
,
glucose
,
infusion procedures
,
insulin secretion
Diabetes February 2003, Vol.52, 380-386. doi:https://doi.org/10.2337/diabetes.52.2.380
Gene Transfer of Manganese Superoxide Dismutase Extends Islet Graft Function in a Mouse Model of Autoimmune Diabetes
Suzanne Bertera; Megan L. Crawford; Angela M. Alexander; Glenn D. Papworth; Simon C. Watkins; Paul D. Robbins; Massimo Trucco
Topics:
autoimmunity
,
gene transfer techniques
,
mice
,
tissue transplants
,
transplantation
Diabetes February 2003, Vol.52, 387-393. doi:https://doi.org/10.2337/diabetes.52.2.387
Differential Effects of Glucose and Glyburide on Energetics and Na+ Levels of βHC9 Cells: Nuclear Magnetic Resonance Spectroscopy and Respirometry Studies
Nicolai M. Doliba; Marko Z. Vatamaniuk; Carol W. Buettger; Wei Qin; Heather W. Collins; Suzanne L. Wehrli; Richard D. Carr; Franz M. Matschinsky
Topics:
glucose
,
insulin
,
mitochondria
,
oxygen consumption
,
spectrum analysis
Diabetes February 2003, Vol.52, 394-402. doi:https://doi.org/10.2337/diabetes.52.2.394
BETA2 Activates Transcription From the Upstream Glucokinase Gene Promoter in Islet β-Cells and Gut Endocrine Cells
Topics:
binding (molecular function)
,
dna
,
enteroendocrine cells
,
gel
,
genes
Diabetes February 2003, Vol.52, 403-408. doi:https://doi.org/10.2337/diabetes.52.2.403
Dominant Negative Pathogenesis by Mutant Proinsulin in the Akita Diabetic Mouse
Tetsuro Izumi; Hiromi Yokota-Hashimoto; Shengli Zhao; Jie Wang; Philippe A. Halban; Toshiyuki Takeuchi
Topics:
cho cells
,
insulin
,
mice
,
proinsulin
,
superior epigastric artery perforator flap
Diabetes February 2003, Vol.52, 409-416. doi:https://doi.org/10.2337/diabetes.52.2.409
Connexin 36 Controls Synchronization of Ca2+ Oscillations and Insulin Secretion in MIN6 Cells
Alessandra Calabrese; Min Zhang; Véronique Serre-Beinier; David Caton; Christophe Mas; Leslie S. Satin; Paolo Meda
Topics:
cell lines
,
clone cells
,
gap junction protein
,
glucose
,
insulin
Diabetes February 2003, Vol.52, 417-424. doi:https://doi.org/10.2337/diabetes.52.2.417
Pax-6 Activates Endogenous Proglucagon Gene Expression in the Rodent Gastrointestinal Epithelium
Topics:
gene expression
,
proglucagon
,
adenoviruses
,
intestines
,
cell culture techniques
Diabetes February 2003, Vol.52, 425-433. doi:https://doi.org/10.2337/diabetes.52.2.425
Pathophysiology
Age-Dependent Changes in Metabolism, Contractile Function, and Ischemic Sensitivity in Hearts From db/db Mice
Topics:
heart
,
ischemia
,
metabolism
,
mice
,
reperfusion therapy
Diabetes February 2003, Vol.52, 434-441. doi:https://doi.org/10.2337/diabetes.52.2.434
Inflammation-Sensitive Plasma Proteins, Diabetes, and Mortality and Incidence of Myocardial Infarction and Stroke: A Population-Based Study
Gunnar Engström; Lars Stavenow; Bo Hedblad; Peter Lind; Karl-Fredrik Eriksson; Lars Janzon; Folke Lindgärde
Topics:
body mass index procedure
,
cardiovascular diseases
,
cerebrovascular accident
,
fibrinogen
,
heart disease risk factors
Diabetes February 2003, Vol.52, 442-447. doi:https://doi.org/10.2337/diabetes.52.2.442
Preferential Stiffening of Central Over Peripheral Arteries in Type 2 Diabetes
Eiji Kimoto; Tetsuo Shoji; Kayo Shinohara; Masaaki Inaba; Yasuhisa Okuno; Takami Miki; Hidenori Koyama; Masanori Emoto; Yoshiki Nishizawa
Diabetes February 2003, Vol.52, 448-452. doi:https://doi.org/10.2337/diabetes.52.2.448
Effects of Insulin Resistance and Type 2 Diabetes on Lipoprotein Subclass Particle Size and Concentration Determined by Nuclear Magnetic Resonance
W. Timothy Garvey; Soonho Kwon; Deyi Zheng; Sara Shaughnessy; Penny Wallace; Amy Hutto; Kimberly Pugh; Alicia J. Jenkins; Richard L. Klein; Youlian Liao
Topics:
diabetes mellitus, type 2
,
high density lipoproteins
,
insulin resistance
,
lipoproteins
,
lipoproteins, vldl
Diabetes February 2003, Vol.52, 453-462. doi:https://doi.org/10.2337/diabetes.52.2.453
Prediction of Type 2 Diabetes Using Simple Measures of Insulin Resistance: Combined Results From the San Antonio Heart Study, the Mexico City Diabetes Study, and the Insulin Resistance Atherosclerosis Study
Anthony J.G. Hanley; Ken Williams; Clicerio Gonzalez; Ralph B. D’Agostino, Jr; Lynne E. Wagenknecht; Michael P. Stern; Steven M. Haffner
Topics:
atherosclerosis
,
diabetes mellitus, type 2
,
fasting
,
glucose
,
heart
Diabetes February 2003, Vol.52, 463-469. doi:https://doi.org/10.2337/diabetes.52.2.463
Altered Homeostatic Adaptation of First- and Second-Phase β-Cell Secretion in the Offspring of Patients With Type 2 Diabetes: Studies With a Minimal Model to Assess β-Cell Function
Riccardo C. Bonadonna; Michael Stumvoll; Andreas Fritsche; Michele Muggeo; Hans Häring; Enzo Bonora; Timon W. van Haeften
Topics:
bodily secretions
,
c-peptide
,
datasets
,
diabetes mellitus, type 2
,
fasting
Diabetes February 2003, Vol.52, 470-480. doi:https://doi.org/10.2337/diabetes.52.2.470
Diabetes Activates Cell Death Pathway After Transient Focal Cerebral Ischemia
Marianna Muranyi; Masayuki Fujioka; QingPing He; Angela Han; Gregory Yong; Katalin Csiszar; Ping-An Li
Topics:
brain injuries
,
caspase-3
,
cerebral ischemia
,
cytochrome c
,
ischemia
Diabetes February 2003, Vol.52, 481-486. doi:https://doi.org/10.2337/diabetes.52.2.481
Effects of Free Fatty Acids on Glucose Uptake and Utilization in Healthy Women
Topics:
carbohydrates
,
glucose
,
glucose uptake
,
glycerol
,
infusion procedures
Diabetes February 2003, Vol.52, 487-491. doi:https://doi.org/10.2337/diabetes.52.2.487
Demonstration of Glycated Insulin in Human Diabetic Plasma and Decreased Biological Activity Assessed by Euglycemic-Hyperinsulinemic Clamp Technique in Humans
Steven J. Hunter; Alison C. Boyd; Finbarr P.M. O’Harte; Aine M. McKillop; M. Ivan Wiggam; Mark H. Mooney; Jane T. McCluskey; John R. Lindsay; Cieran N. Ennis; Raymond Gamble; Brian Sheridan; Christopher R. Barnett; Helene McNulty; Patrick M. Bell; Peter R. Flatt
Diabetes February 2003, Vol.52, 492-498. doi:https://doi.org/10.2337/diabetes.52.2.492
Complications
Comparative Trial of N-Acetyl-Cysteine, Taurine, and Oxerutin on Skin and Kidney Damage in Long-Term Experimental Diabetes
Patrizio Odetti; Carlo Pesce; Nicola Traverso; Stefano Menini; Elena Pesce Maineri; Luana Cosso; Sabina Valentini; Stefania Patriarca; Damiano Cottalasso; Umberto M. Marinari; Maria Adelaide Pronzato
Topics:
cysteine
,
diabetes mellitus, experimental
,
fluorescence
,
kidney
,
kidney glomerulus
Diabetes February 2003, Vol.52, 499-505. doi:https://doi.org/10.2337/diabetes.52.2.499
A Role for the Polyol Pathway in the Early Neuroretinal Apoptosis and Glial Changes Induced by Diabetes in the Rat
Topics:
apoptosis
,
glial fibrillary acidic protein
,
rats
,
retina
,
mice
Diabetes February 2003, Vol.52, 506-511. doi:https://doi.org/10.2337/diabetes.52.2.506
Protein Kinase C β Inhibition Attenuates the Progression of Experimental Diabetic Nephropathy in the Presence of Continued Hypertension
Darren J. Kelly; Yuan Zhang; Claire Hepper; Renae M. Gow; Kassie Jaworski; Bruce E. Kemp; Jennifer L. Wilkinson-Berka; Richard E. Gilbert
Topics:
albuminuria
,
diabetic nephropathy
,
fluorescent antibody technique
,
hypertension
,
immunohistochemistry
Diabetes February 2003, Vol.52, 512-518. doi:https://doi.org/10.2337/diabetes.52.2.512
Glucose-Induced Phosphatidylinositol 3-Kinase and Mitogen-Activated Protein Kinase-Dependent Upregulation of the Platelet-Derived Growth Factor-β Receptor Potentiates Vascular Smooth Muscle Cell Chemotaxis
Topics:
glucose
,
1-phosphatidylinositol 3-kinase
Diabetes February 2003, Vol.52, 519-526. doi:https://doi.org/10.2337/diabetes.52.2.519
Evidence for a Novel TGF-β1−Independent Mechanism of Fibronectin Production in Mesangial Cells Overexpressing Glucose Transporters
Cora Weigert; Katrin Brodbeck; Frank C. Brosius III; Matthias Huber; Rainer Lehmann; Ulrich Friess; Sonia Facchin; Steffen Aulwurm; Hans U. Häring; Erwin D. Schleicher; Charles W. Heilig
Topics:
dna
,
fibronectins
,
transcription factor ap-1
,
glucose
,
mesangial cells
Diabetes February 2003, Vol.52, 527-535. doi:https://doi.org/10.2337/diabetes.52.2.527
Amelioration of Sensory Nerve Dysfunction by C-Peptide in Patients With Type 1 Diabetes
Topics:
c-peptide
,
diabetes mellitus, type 1
,
sensory nerves
Diabetes February 2003, Vol.52, 536-541. doi:https://doi.org/10.2337/diabetes.52.2.536
Microvascular Alterations in Diabetic Mice Correlate With Level of Hyperglycemia
Petra Algenstaedt; Christian Schaefer; Tanja Biermann; Andreas Hamann; Britta Schwarzloh; Heiner Greten; Wolfgang Rüther; Nils Hansen-Algenstaedt
Topics:
blood glucose
,
glucose tolerance test
,
hyperglycemia
,
mice
,
ucp1 gene
Diabetes February 2003, Vol.52, 542-549. doi:https://doi.org/10.2337/diabetes.52.2.542
Genetics
Genome-Wide and Fine-Mapping Linkage Studies of Type 2 Diabetes and Glucose Traits in the Old Order Amish: Evidence for a New Diabetes Locus on Chromosome 14q11 and Confirmation of a Locus on Chromosome 1q21-q24
Wen-Chi Hsueh; Pamela L. St. Jean; Braxton D. Mitchell; Toni I. Pollin; William C. Knowler; Margaret G. Ehm; Callum J. Bell; Hakan Sakul; Michael J. Wagner; Daniel K. Burns; Alan R. Shuldiner
Topics:
chromosomes
,
diabetes mellitus, type 2
,
genetic linkage analysis
,
genome
,
glucose
Diabetes February 2003, Vol.52, 550-557. doi:https://doi.org/10.2337/diabetes.52.2.550
Brief Genetics Reports
The C-174G Promoter Polymorphism of the IL-6 Gene Affects Energy Expenditure and Insulin Sensitivity
Topics:
energy metabolism
,
genes
,
insulin sensitivity
,
interleukin-6
,
polymorphism
Diabetes February 2003, Vol.52, 558-561. doi:https://doi.org/10.2337/diabetes.52.2.558
Systematic Search for Single Nucleotide Polymorphisms in the FOXC2 Gene: The Absence of Evidence for the Association of Three Frequent Single Nucleotide Polymorphisms and Four Common Haplotypes With Japanese Type 2 Diabetes
Haruhiko Osawa; Hiroshi Onuma; Akiko Murakami; Masaaki Ochi; Tatsuya Nishimiya; Kenichi Kato; Ikki Shimizu; Yasuhisa Fujii; Jun Ohashi; Hideichi Makino
Topics:
diabetes mellitus, type 2
,
foxc2 gene
,
haplotypes
,
single nucleotide polymorphism
,
polymerase chain reaction
Diabetes February 2003, Vol.52, 562-567. doi:https://doi.org/10.2337/diabetes.52.2.562
Large-Scale Association Studies of Variants in Genes Encoding the Pancreatic β-Cell KATP Channel Subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) Confirm That the KCNJ11 E23K Variant Is Associated With Type 2 Diabetes
Anna L. Gloyn; Michael N. Weedon; Katharine R. Owen; Martina J. Turner; Bridget A. Knight; Graham Hitman; Mark Walker; Jonathan C. Levy; Mike Sampson; Stephanie Halford; Mark I. McCarthy; Andrew T. Hattersley; Timothy M. Frayling
Topics:
abcc8 gene
,
diabetes mellitus, type 2
,
kcnj11 gene
,
alleles
,
genes
Diabetes February 2003, Vol.52, 568-572. doi:https://doi.org/10.2337/diabetes.52.2.568
The E23K Variant of Kir6.2 Associates With Impaired Post-OGTT Serum Insulin Response and Increased Risk of Type 2 Diabetes
Eva-Maria D. Nielsen; Lars Hansen; Bendix Carstensen; Søren M. Echwald; Thomas Drivsholm; Charlotte Glümer; Birger Thorsteinsson; Knut Borch-Johnsen; Torben Hansen; Oluf Pedersen
Topics:
diabetes mellitus, type 2
,
glucose
,
insulin
,
oral glucose tolerance test
,
genotype
Diabetes February 2003, Vol.52, 573-577. doi:https://doi.org/10.2337/diabetes.52.2.573
Erratum
Errata
Topics:
infusion procedures
,
insulin
,
osmotic pump system
,
tumor necrosis factors
Diabetes February 2003, Vol.52, 578. doi:https://doi.org/10.2337/diabetes.52.2.578
