Skip Nav Destination
Issues
1 March 2003
ISSN 0012-1797
EISSN 1939-327X
Perspectives in Diabetes
Glucose Toxicity in β-Cells: Type 2 Diabetes, Good Radicals Gone Bad, and the Glutathione Connection
Diabetes March 2003, Vol.52, 581-587. doi:https://doi.org/10.2337/diabetes.52.3.581
Metabolism and Signal Transduction
Selective Glycogen Synthase Kinase 3 Inhibitors Potentiate Insulin Activation of Glucose Transport and Utilization In Vitro and In Vivo
David B. Ring; Kirk W. Johnson; Erik J. Henriksen; John M. Nuss; Dane Goff; Tyson R. Kinnick; Sylvia T. Ma; John W. Reeder; Isa Samuels; Trina Slabiak; Allan S. Wagman; Mary-Ellen Wernette Hammond; Stephen D. Harrison
Diabetes March 2003, Vol.52, 588-595. doi:https://doi.org/10.2337/diabetes.52.3.588
Disruption of the Striated Muscle Glycogen Targeting Subunit PPP1R3A of Protein Phosphatase 1 Leads to Increased Weight Gain, Fat Deposition, and Development of Insulin Resistance
Mirela Delibegovic; Christopher G. Armstrong; Lorraine Dobbie; Peter W. Watt; Andrew J.H. Smith; Patricia T.W. Cohen
Diabetes March 2003, Vol.52, 596-604. doi:https://doi.org/10.2337/diabetes.52.3.596
Role of Corticotrophin-Releasing Hormone in the Impairment of Counterregulatory Responses to Hypoglycemia
Daniel E. Flanagan; Tara Keshavarz; Mark L. Evans; Sally Flanagan; Xiaoning Fan; Ralph J. Jacob; Robert S. Sherwin
Diabetes March 2003, Vol.52, 605-613. doi:https://doi.org/10.2337/diabetes.52.3.605
Contribution of Fatty Acids Released From Lipolysis of Plasma Triglycerides to Total Plasma Fatty Acid Flux and Tissue-Specific Fatty Acid Uptake
Bas Teusink; Peter J. Voshol; Vivian E.H. Dahlmans; Patrick C.N. Rensen; Hanno Pijl; Johannes A. Romijn; Louis M. Havekes
Diabetes March 2003, Vol.52, 614-620. doi:https://doi.org/10.2337/diabetes.52.3.614
Acute Hyperglycemia Causes Intracellular Formation of CML and Activation of ras, p42/44 MAPK, and Nuclear Factor κB in PBMCs
Stephan Schiekofer; Martin Andrassy; Jiang Chen; Gottfried Rudofsky; Jochen Schneider; Thoralf Wendt; Norbert Stefan; Per Humpert; Andreas Fritsche; Michael Stumvoll; Erwin Schleicher; Hans-Ulrich Häring; Peter P. Nawroth; Angelika Bierhaus
Diabetes March 2003, Vol.52, 621-633. doi:https://doi.org/10.2337/diabetes.52.3.621
Enhanced Basal Activation of Mitogen-Activated Protein Kinases in Adipocytes From Type 2 Diabetes: Potential Role of p38 in the Downregulation of GLUT4 Expression
Christian J. Carlson; Sandra Koterski; Richard J. Sciotti; German Braillard Poccard; Cristina M. Rondinone
Diabetes March 2003, Vol.52, 634-641. doi:https://doi.org/10.2337/diabetes.52.3.634
Regulation of PGC-1 Promoter Activity by Protein Kinase B and the Forkhead Transcription Factor FKHR
Diabetes March 2003, Vol.52, 642-649. doi:https://doi.org/10.2337/diabetes.52.3.642
Palmitate-Induced Activation of the Hexosamine Pathway in Human Myotubes: Increased Expression of Glutamine:Fructose-6-Phosphate Aminotransferase
Cora Weigert; Karsten Klopfer; Christiana Kausch; Katrin Brodbeck; Michael Stumvoll; Hans U. Häring; Erwin D. Schleicher
Diabetes March 2003, Vol.52, 650-656. doi:https://doi.org/10.2337/diabetes.52.3.650
Effect of Short-Term Fasting and Refeeding on Transcriptional Regulation of Metabolic Genes in Human Skeletal Muscle
Diabetes March 2003, Vol.52, 657-662. doi:https://doi.org/10.2337/diabetes.52.3.657
Local Lactate Perfusion of the Ventromedial Hypothalamus Suppresses Hypoglycemic Counterregulation
Diabetes March 2003, Vol.52, 663-666. doi:https://doi.org/10.2337/diabetes.52.3.663
Modulation of Circulating and Adipose Tissue Adiponectin Levels by Antidiabetic Therapy
Susan A. Phillips; Theodore P. Ciaraldi; Alice P.S. Kong; Rahil Bandukwala; Vanita Aroda; Leslie Carter; Sunita Baxi; Sunder R. Mudaliar; Robert R. Henry
Diabetes March 2003, Vol.52, 667-674. doi:https://doi.org/10.2337/diabetes.52.3.667
Nocturnal and Postprandial Free Fatty Acid Kinetics in Normal and Type 2 Diabetic Subjects: Effects of Insulin Sensitization Therapy
John M. Miles; David Wooldridge; Wayne J. Grellner; Sheryl Windsor; William L. Isley; Samuel Klein; William S. Harris
Diabetes March 2003, Vol.52, 675-681. doi:https://doi.org/10.2337/diabetes.52.3.675
Obesity Studies
Differential Sensitivity to Central Leptin and Insulin in Male and Female Rats
Diabetes March 2003, Vol.52, 682-687. doi:https://doi.org/10.2337/diabetes.52.3.682
Gene Expression Profiles of Nondiabetic and Diabetic Obese Mice Suggest a Role of Hepatic Lipogenic Capacity in Diabetes Susceptibility
Hong Lan; Mary E. Rabaglia; Jonathan P. Stoehr; Samuel T. Nadler; Kathryn L. Schueler; Fei Zou; Brian S. Yandell; Alan D. Attie
Diabetes March 2003, Vol.52, 688-700. doi:https://doi.org/10.2337/diabetes.52.3.688
Effects of Identical Weight Loss on Body Composition and Features of Insulin Resistance in Obese Women With High and Low Liver Fat Content
Mirja Tiikkainen; Robert Bergholm; Satu Vehkavaara; Aila Rissanen; Anna-Maija Häkkinen; Marjo Tamminen; Kari Teramo; Hannele Yki-Järvinen
Diabetes March 2003, Vol.52, 701-707. doi:https://doi.org/10.2337/diabetes.52.3.701
Immunology and Transplantation
Adeno-Associated Virus-Mediated IL-10 Gene Therapy Inhibits Diabetes Recurrence in Syngeneic Islet Cell Transplantation of NOD Mice
Y. Clare Zhang; Antonello Pileggi; Anupam Agarwal; R. Damaris Molano; Matthew Powers; Todd Brusko; Clive Wasserfall; Kevin Goudy; Elsie Zahr; Raffaella Poggioli; Marda Scott-Jorgensen; Martha Campbell-Thompson; James M. Crawford; Harry Nick; Terence Flotte; Tamir M. Ellis; Camillo Ricordi; Luca Inverardi; Mark A. Atkinson
Diabetes March 2003, Vol.52, 708-716. doi:https://doi.org/10.2337/diabetes.52.3.708
Processing and Presentation of the Islet Autoantigen GAD by Vascular Endothelial Cells Promotes Transmigration of Autoreactive T-Cells
James E. Greening; Timothy I.M. Tree; Karolena T. Kotowicz; Astrid G. van Halteren; Bart O. Roep; Nigel J. Klein; Mark Peakman
Diabetes March 2003, Vol.52, 717-725. doi:https://doi.org/10.2337/diabetes.52.3.717
Islet Studies
Neonatal Exendin-4 Prevents the Development of Diabetes in the Intrauterine Growth Retarded Rat
Diabetes March 2003, Vol.52, 734-740. doi:https://doi.org/10.2337/diabetes.52.3.734
Dipeptidyl Peptidase IV Inhibitor Treatment Stimulates β-Cell Survival and Islet Neogenesis in Streptozotocin-Induced Diabetic Rats
J. Andrew Pospisilik; Jennifer Martin; Timothy Doty; Jan A. Ehses; Nathalie Pamir; Francis C. Lynn; Shalea Piteau; Hans-Ulrich Demuth; Christopher H.S. McIntosh; Raymond A. Pederson
Diabetes March 2003, Vol.52, 741-750. doi:https://doi.org/10.2337/diabetes.52.3.741
Development and Characterization of a Glucagon-Like Peptide 1-Albumin Conjugate: The Ability to Activate the Glucagon-Like Peptide 1 Receptor In Vivo
Jung-Guk Kim; Laurie L. Baggio; Dominique P. Bridon; Jean-Paul Castaigne; Martin F. Robitaille; Lucie Jetté; Corinne Benquet; Daniel J. Drucker
Diabetes March 2003, Vol.52, 751-759. doi:https://doi.org/10.2337/diabetes.52.3.751
Role of H1-Calponin in Pancreatic AR42J Cell Differentiation Into Insulin-Producing Cells
Tomoaki Morioka; Hidenori Koyama; Hisako Yamamura; Shinji Tanaka; Shinya Fukumoto; Masanori Emoto; Hiroyuki Mizuguchi; Takao Hayakawa; Itaru Kojima; Katsuhito Takahashi; Yoshiki Nishizawa
Diabetes March 2003, Vol.52, 760-766. doi:https://doi.org/10.2337/diabetes.52.3.760
The Insulin Secretory Granule Is the Major Site of KATP Channels of the Endocrine Pancreas
Diabetes March 2003, Vol.52, 767-776. doi:https://doi.org/10.2337/diabetes.52.3.767
Pathophysiology
Metallothionein Prevents Diabetes-Induced Deficits in Cardiomyocytes by Inhibiting Reactive Oxygen Species Production
Diabetes March 2003, Vol.52, 777-783. doi:https://doi.org/10.2337/diabetes.52.3.777
The Focal Form of Persistent Hyperinsulinemic Hypoglycemia of Infancy: Morphological and Molecular Studies Show Structural and Functional Differences With Insulinoma
Christine Sempoux; Yves Guiot; Karin Dahan; Pierre Moulin; Martine Stevens; Virginie Lambot; Pascale de Lonlay; Jean-Christophe Fournet; Claudine Junien; Francis Jaubert; Claire Nihoul-Fekete; Jean-Marie Saudubray; Jacques Rahier
Diabetes March 2003, Vol.52, 784-794. doi:https://doi.org/10.2337/diabetes.52.3.784
l-Arginine-Nitric Oxide Kinetics in Normal and Type 2 Diabetic Subjects: A Stable-Labelled 15N Arginine Approach
Angelo Avogaro; Gianna Toffolo; Edward Kiwanuka; Saula Vigili de Kreutzenberg; Paolo Tessari; Claudio Cobelli
Diabetes March 2003, Vol.52, 795-802. doi:https://doi.org/10.2337/diabetes.52.3.795
Differential Regulation of Lipoprotein Kinetics by Atorvastatin and Fenofibrate in Subjects With the Metabolic Syndrome
Gerald F. Watts; P. Hugh R. Barrett; Juying Ji; Adrian P. Serone; Dick C. Chan; Kevin D. Croft; Franziska Loehrer; Anthony G. Johnson
Diabetes March 2003, Vol.52, 803-811. doi:https://doi.org/10.2337/diabetes.52.3.803
Inflammatory Cytokines and the Risk to Develop Type 2 Diabetes: Results of the Prospective Population-Based European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study
Joachim Spranger; Anja Kroke; Matthias Möhlig; Kurt Hoffmann; Manuela M. Bergmann; Michael Ristow; Heiner Boeing; Andreas F.H. Pfeiffer
Diabetes March 2003, Vol.52, 812-817. doi:https://doi.org/10.2337/diabetes.52.3.812
Complications
Effect of Reinstitution of Good Glycemic Control on Retinal Oxidative Stress and Nitrative Stress in Diabetic Rats
Diabetes March 2003, Vol.52, 818-823. doi:https://doi.org/10.2337/diabetes.52.3.818
Characterization of Retinal Leukostasis and Hemodynamics in Insulin Resistance and Diabetes: Role of Oxidants and Protein Kinase-C Activation
Toru Abiko; Atsuko Abiko; Allen C. Clermont; Brett Shoelson; Naoichi Horio; Junichi Takahashi; Anthony P. Adamis; George L. King; Sven-Erik Bursell
Diabetes March 2003, Vol.52, 829-837. doi:https://doi.org/10.2337/diabetes.52.3.829
Role of Protein Kinase C on the Expression of Platelet-Derived Growth Factor and Endothelin-1 in the Retina of Diabetic Rats and Cultured Retinal Capillary Pericytes
Tamotsu Yokota; Ronald C. Ma; Joong-Yeol Park; Keiji Isshiki; Konstantinos B. Sotiropoulos; Ravi K. Rauniyar; Karin E. Bornfeldt; George L. King
Diabetes March 2003, Vol.52, 838-845. doi:https://doi.org/10.2337/diabetes.52.3.838
The Response of Antioxidant Genes to Hyperglycemia Is Abnormal in Patients With Type 1 Diabetes and Diabetic Nephropathy
Diabetes March 2003, Vol.52, 846-851. doi:https://doi.org/10.2337/diabetes.52.3.846
Increased Serum IGF-I During Pregnancy Is Associated With Progression of Diabetic Retinopathy
Diabetes March 2003, Vol.52, 852-856. doi:https://doi.org/10.2337/diabetes.52.3.852
Aldose Reductase Inhibitor Fidarestat Prevents Retinal Oxidative Stress and Vascular Endothelial Growth Factor Overexpression in Streptozotocin-Diabetic Rats
Irina G. Obrosova; Alexander G. Minchenko; Rukmini Vasupuram; Lauren White; Omorodola I. Abatan; Arno K. Kumagai; Robert N. Frank; Martin J. Stevens
Diabetes March 2003, Vol.52, 864-871. doi:https://doi.org/10.2337/diabetes.52.3.864
Genetics
A Genome-Wide Scan in Families With Maturity-Onset Diabetes of the Young: Evidence for Further Genetic Heterogeneity
Timothy M. Frayling; Cecilia M. Lindgren; Jean Claude Chevre; Stephan Menzel; Marie Wishart; Yamina Benmezroua; Alison Brown; Julie C. Evans; Pamidghantam Subba Rao; Christian Dina; Cécile Lecoeur; Timo Kanninen; Peter Almgren; Michael P. Bulman; Youxiang Wang; James Mills; Rosemarie Wright-Pascoe; Melanie M. Mahtani; Francesco Prisco; Angels Costa; Ignacio Cognet; Torben Hansen; Oluf Pedersen; Sian Ellard; Tiinamaija Tuomi; Leif C. Groop; Philippe Froguel; Andrew T. Hattersley; Martine Vaxillaire
Diabetes March 2003, Vol.52, 872-881. doi:https://doi.org/10.2337/diabetes.52.3.872
Brief Genetics Reports
Insulin Autoantibodies Are Associated With Islet Inflammation But Not Always Related to Diabetes Progression in NOD Congenic Mice
Diabetes March 2003, Vol.52, 882-886. doi:https://doi.org/10.2337/diabetes.52.3.882
The Gly972→Arg IRS-1 Variant Is Associated With Type 1 Diabetes in Continental Italy
Massimo Federici; Antonio Petrone; Ottavia Porzio; Carla Bizzarri; Davide Lauro; Rossella D’Alfonso; Ippolita Patera; Marco Cappa; Lorenza Nisticò; Marco Baroni; Giorgio Sesti; Umberto di Mario; Renato Lauro; Raffaella Buzzetti
Diabetes March 2003, Vol.52, 887-890. doi:https://doi.org/10.2337/diabetes.52.3.887
The Functional −374 T/A RAGE Gene Polymorphism Is Associated With Proteinuria and Cardiovascular Disease in Type 1 Diabetic Patients
Kim Pettersson-Fernholm; Carol Forsblom; Barry I. Hudson; Markus Perola; Peter J. Grant; Per-Henrik Groop; for the FinnDiane Study Group
Diabetes March 2003, Vol.52, 891-894. doi:https://doi.org/10.2337/diabetes.52.3.891
