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Perspectives in Diabetes

Glucose Toxicity in β-Cells: Type 2 Diabetes, Good Radicals Gone Bad, and the Glutathione Connection

R. Paul Robertson; Jamie Harmon; Phuong Oanh Tran; Yoshito Tanaka; Hiroki Takahashi

Abstracts

View articletitled, Glucose Toxicity in β-Cells: Type 2 Diabetes, Good Radicals Gone Bad, and the Glutathione Connection

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Topics: glucose , toxic effect , diabetes mellitus, type 2 , antioxidants , insulin

Diabetes March 2003, Vol.52, 581-587. doi:https://doi.org/10.2337/diabetes.52.3.581

Metabolism and Signal Transduction

Selective Glycogen Synthase Kinase 3 Inhibitors Potentiate Insulin Activation of Glucose Transport and Utilization In Vitro and In Vivo

David B. Ring; Kirk W. Johnson; Erik J. Henriksen; John M. Nuss; Dane Goff; Tyson R. Kinnick; Sylvia T. Ma; John W. Reeder; Isa Samuels; Trina Slabiak; Allan S. Wagman; Mary-Ellen Wernette Hammond; Stephen D. Harrison

Abstracts

View articletitled, Selective Glycogen Synthase Kinase 3 Inhibitors Potentiate Insulin Activation of Glucose Transport and Utilization In Vitro and In Vivo

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Topics: glycogen synthase kinase 3 , insulin , glucose , glucose transport

Diabetes March 2003, Vol.52, 588-595. doi:https://doi.org/10.2337/diabetes.52.3.588

Disruption of the Striated Muscle Glycogen Targeting Subunit PPP1R3A of Protein Phosphatase 1 Leads to Increased Weight Gain, Fat Deposition, and Development of Insulin Resistance

Mirela Delibegovic; Christopher G. Armstrong; Lorraine Dobbie; Peter W. Watt; Andrew J.H. Smith; Patricia T.W. Cohen

Abstracts

View articletitled, Disruption of the Striated Muscle Glycogen Targeting Subunit PPP1R3A of Protein Phosphatase 1 Leads to Increased Weight Gain, Fat Deposition, and Development of Insulin Resistance

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Topics: glycogen , insulin , insulin resistance , mice , skeletal muscles

Diabetes March 2003, Vol.52, 596-604. doi:https://doi.org/10.2337/diabetes.52.3.596

Role of Corticotrophin-Releasing Hormone in the Impairment of Counterregulatory Responses to Hypoglycemia

Daniel E. Flanagan; Tara Keshavarz; Mark L. Evans; Sally Flanagan; Xiaoning Fan; Ralph J. Jacob; Robert S. Sherwin

Abstracts

View articletitled, Role of Corticotrophin-Releasing Hormone in the Impairment of Counterregulatory Responses to Hypoglycemia

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Topics: corticosterone , corticotropin , hypoglycemia , hypoglycemic agents , insulin

Diabetes March 2003, Vol.52, 605-613. doi:https://doi.org/10.2337/diabetes.52.3.605

Contribution of Fatty Acids Released From Lipolysis of Plasma Triglycerides to Total Plasma Fatty Acid Flux and Tissue-Specific Fatty Acid Uptake

Bas Teusink; Peter J. Voshol; Vivian E.H. Dahlmans; Patrick C.N. Rensen; Hanno Pijl; Johannes A. Romijn; Louis M. Havekes

Abstracts

View articletitled, Contribution of Fatty Acids Released From Lipolysis of Plasma Triglycerides to Total Plasma Fatty Acid Flux and Tissue-Specific Fatty Acid Uptake

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Topics: emulsions , infusion procedures , lipids , plasma , transforming growth factor alpha

Diabetes March 2003, Vol.52, 614-620. doi:https://doi.org/10.2337/diabetes.52.3.614

Acute Hyperglycemia Causes Intracellular Formation of CML and Activation of ras, p42/44 MAPK, and Nuclear Factor κB in PBMCs

Stephan Schiekofer; Martin Andrassy; Jiang Chen; Gottfried Rudofsky; Jochen Schneider; Thoralf Wendt; Norbert Stefan; Per Humpert; Andreas Fritsche; Michael Stumvoll; Erwin Schleicher; Hans-Ulrich Häring; Peter P. Nawroth; Angelika Bierhaus

Abstracts

View articletitled, Acute Hyperglycemia Causes Intracellular Formation of CML and Activation of ras, p42/44 MAPK, and Nuclear Factor κB in PBMCs

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Topics: hyperglycemia , hyperglycemia, acute , hyperglycemic agents , mitogen-activated protein kinases , western blotting

Diabetes March 2003, Vol.52, 621-633. doi:https://doi.org/10.2337/diabetes.52.3.621

Enhanced Basal Activation of Mitogen-Activated Protein Kinases in Adipocytes From Type 2 Diabetes: Potential Role of p38 in the Downregulation of GLUT4 Expression

Christian J. Carlson; Sandra Koterski; Richard J. Sciotti; German Braillard Poccard; Cristina M. Rondinone

Abstracts

View articletitled, Enhanced Basal Activation of Mitogen-Activated Protein Kinases in Adipocytes From Type 2 Diabetes: Potential Role of p38 in the Downregulation of GLUT4 Expression

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Topics: adipocytes , diabetes mellitus, type 2 , glut-4 protein , insulin , irs1 protein, human

Diabetes March 2003, Vol.52, 634-641. doi:https://doi.org/10.2337/diabetes.52.3.634

Regulation of PGC-1 Promoter Activity by Protein Kinase B and the Forkhead Transcription Factor FKHR

Hiroaki Daitoku; Kazuyuki Yamagata; Hitomi Matsuzaki; Mitsutoki Hatta; Akiyoshi Fukamizu

Abstracts

View articletitled, Regulation of PGC-1 Promoter Activity by Protein Kinase B and the Forkhead Transcription Factor FKHR

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Topics: insulin , transcription factor

Diabetes March 2003, Vol.52, 642-649. doi:https://doi.org/10.2337/diabetes.52.3.642

Palmitate-Induced Activation of the Hexosamine Pathway in Human Myotubes: Increased Expression of Glutamine:Fructose-6-Phosphate Aminotransferase

Cora Weigert; Karsten Klopfer; Christiana Kausch; Katrin Brodbeck; Michael Stumvoll; Hans U. Häring; Erwin D. Schleicher

Abstracts

View articletitled, Palmitate-Induced Activation of the Hexosamine Pathway in Human Myotubes: Increased Expression of Glutamine:Fructose-6-Phosphate Aminotransferase

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Topics: palmitates , rna, messenger , skeletal myocytes , dna , hexosamines

Diabetes March 2003, Vol.52, 650-656. doi:https://doi.org/10.2337/diabetes.52.3.650

Effect of Short-Term Fasting and Refeeding on Transcriptional Regulation of Metabolic Genes in Human Skeletal Muscle

Henriette Pilegaard; Bengt Saltin; P. Darrell Neufer

Abstracts

View articletitled, Effect of Short-Term Fasting and Refeeding on Transcriptional Regulation of Metabolic Genes in Human Skeletal Muscle

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Topics: fasting , genes , refeeding syndrome , rna, messenger , skeletal muscles

Diabetes March 2003, Vol.52, 657-662. doi:https://doi.org/10.2337/diabetes.52.3.657

Local Lactate Perfusion of the Ventromedial Hypothalamus Suppresses Hypoglycemic Counterregulation

Monica A. Borg; William V. Tamborlane; Gerald I. Shulman; Robert S. Sherwin

Abstracts

View articletitled, Local Lactate Perfusion of the Ventromedial Hypothalamus Suppresses Hypoglycemic Counterregulation

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Topics: glucose , hypoglycemia , hypoglycemic agents , lactates , microdialysis

Diabetes March 2003, Vol.52, 663-666. doi:https://doi.org/10.2337/diabetes.52.3.663

Modulation of Circulating and Adipose Tissue Adiponectin Levels by Antidiabetic Therapy

Susan A. Phillips; Theodore P. Ciaraldi; Alice P.S. Kong; Rahil Bandukwala; Vanita Aroda; Leslie Carter; Sunita Baxi; Sunder R. Mudaliar; Robert R. Henry

Abstracts

View articletitled, Modulation of Circulating and Adipose Tissue Adiponectin Levels by Antidiabetic Therapy

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Topics: adiponectin , adipocytes , troglitazone , insulin , metformin

Diabetes March 2003, Vol.52, 667-674. doi:https://doi.org/10.2337/diabetes.52.3.667

Nocturnal and Postprandial Free Fatty Acid Kinetics in Normal and Type 2 Diabetic Subjects: Effects of Insulin Sensitization Therapy

John M. Miles; David Wooldridge; Wayne J. Grellner; Sheryl Windsor; William L. Isley; Samuel Klein; William S. Harris

Abstracts

View articletitled, Nocturnal and Postprandial Free Fatty Acid Kinetics in Normal and Type 2 Diabetic Subjects: Effects of Insulin Sensitization Therapy

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Topics: diabetes mellitus, type 2 , insulin , kinetics , night time , nonesterified fatty acids

Diabetes March 2003, Vol.52, 675-681. doi:https://doi.org/10.2337/diabetes.52.3.675

Obesity Studies

Differential Sensitivity to Central Leptin and Insulin in Male and Female Rats

Deborah J. Clegg; Christine A. Riedy; Kathleen A. Blake Smith; Stephen C. Benoit; Stephen C. Woods

Abstracts

View articletitled, Differential Sensitivity to Central Leptin and Insulin in Male and Female Rats

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Topics: eating , insulin , leptin , rats

Diabetes March 2003, Vol.52, 682-687. doi:https://doi.org/10.2337/diabetes.52.3.682

Gene Expression Profiles of Nondiabetic and Diabetic Obese Mice Suggest a Role of Hepatic Lipogenic Capacity in Diabetes Susceptibility

Hong Lan; Mary E. Rabaglia; Jonathan P. Stoehr; Samuel T. Nadler; Kathryn L. Schueler; Fei Zou; Brian S. Yandell; Alan D. Attie

Abstracts

View articletitled, Gene Expression Profiles of Nondiabetic and Diabetic Obese Mice Suggest a Role of Hepatic Lipogenic Capacity in Diabetes Susceptibility

Supplementary data

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Topics: adipose tissue , genes , liver , mice , obesity

Diabetes March 2003, Vol.52, 688-700. doi:https://doi.org/10.2337/diabetes.52.3.688

Effects of Identical Weight Loss on Body Composition and Features of Insulin Resistance in Obese Women With High and Low Liver Fat Content

Mirja Tiikkainen; Robert Bergholm; Satu Vehkavaara; Aila Rissanen; Anna-Maija Häkkinen; Marjo Tamminen; Kari Teramo; Hannele Yki-Järvinen

Abstracts

View articletitled, Effects of Identical Weight Loss on Body Composition and Features of Insulin Resistance in Obese Women With High and Low Liver Fat Content

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Topics: obesity , weight reduction , insulin resistance , liver , abdomen

Diabetes March 2003, Vol.52, 701-707. doi:https://doi.org/10.2337/diabetes.52.3.701

Immunology and Transplantation

Adeno-Associated Virus-Mediated IL-10 Gene Therapy Inhibits Diabetes Recurrence in Syngeneic Islet Cell Transplantation of NOD Mice

Y. Clare Zhang; Antonello Pileggi; Anupam Agarwal; R. Damaris Molano; Matthew Powers; Todd Brusko; Clive Wasserfall; Kevin Goudy; Elsie Zahr; Raffaella Poggioli; Marda Scott-Jorgensen; Martha Campbell-Thompson; James M. Crawford; Harry Nick; Terence Flotte; Tamir M. Ellis; Camillo Ricordi; Luca Inverardi; Mark A. Atkinson

Abstracts

View articletitled, Adeno-Associated Virus-Mediated IL-10 Gene Therapy Inhibits Diabetes Recurrence in Syngeneic Islet Cell Transplantation of NOD Mice

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Topics: interleukin-10 , islets of langerhans transplantation , mice , tissue transplants , transplantation

Diabetes March 2003, Vol.52, 708-716. doi:https://doi.org/10.2337/diabetes.52.3.708

Processing and Presentation of the Islet Autoantigen GAD by Vascular Endothelial Cells Promotes Transmigration of Autoreactive T-Cells

James E. Greening; Timothy I.M. Tree; Karolena T. Kotowicz; Astrid G. van Halteren; Bart O. Roep; Nigel J. Klein; Mark Peakman

Abstracts

View articletitled, Processing and Presentation of the Islet Autoantigen GAD by Vascular Endothelial Cells Promotes Transmigration of Autoreactive T-Cells

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Topics: antigens , autoantigens , electroconvulsive therapy , epidural cortical stimulation , peptides

Diabetes March 2003, Vol.52, 717-725. doi:https://doi.org/10.2337/diabetes.52.3.717

Islet Studies

Monounsaturated Fatty Acids Prevent the Deleterious Effects of Palmitate and High Glucose on Human Pancreatic β-Cell Turnover and Function

Kathrin Maedler; José Oberholzer; Pascal Bucher; Giatgen A. Spinas; Marc Y. Donath

Abstracts

View articletitled, Monounsaturated Fatty Acids Prevent the Deleterious Effects of Palmitate and High Glucose on Human Pancreatic β-Cell Turnover and Function

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Topics: apoptosis , glucose , monounsaturated fatty acids , palmitic acid , ceramides

Diabetes March 2003, Vol.52, 726-733. doi:https://doi.org/10.2337/diabetes.52.3.726

Neonatal Exendin-4 Prevents the Development of Diabetes in the Intrauterine Growth Retarded Rat

Doris A. Stoffers; Biva M. Desai; Diva D. DeLeon; Rebecca A. Simmons

Abstracts

View articletitled, Neonatal Exendin-4 Prevents the Development of Diabetes in the Intrauterine Growth Retarded Rat

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Topics: fetal growth retardation , newborn , rats , exenatide , growth retardation

Diabetes March 2003, Vol.52, 734-740. doi:https://doi.org/10.2337/diabetes.52.3.734

Dipeptidyl Peptidase IV Inhibitor Treatment Stimulates β-Cell Survival and Islet Neogenesis in Streptozotocin-Induced Diabetic Rats

J. Andrew Pospisilik; Jennifer Martin; Timothy Doty; Jan A. Ehses; Nathalie Pamir; Francis C. Lynn; Shalea Piteau; Hans-Ulrich Demuth; Christopher H.S. McIntosh; Raymond A. Pederson

Abstracts

View articletitled, Dipeptidyl Peptidase IV Inhibitor Treatment Stimulates β-Cell Survival and Islet Neogenesis in Streptozotocin-Induced Diabetic Rats

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Topics: insulin , streptozocin , pancreas , plasma , glucagon-like peptide 1

Diabetes March 2003, Vol.52, 741-750. doi:https://doi.org/10.2337/diabetes.52.3.741

Development and Characterization of a Glucagon-Like Peptide 1-Albumin Conjugate: The Ability to Activate the Glucagon-Like Peptide 1 Receptor In Vivo

Jung-Guk Kim; Laurie L. Baggio; Dominique P. Bridon; Jean-Paul Castaigne; Martin F. Robitaille; Lucie Jetté; Corinne Benquet; Daniel J. Drucker

Abstracts

View articletitled, Development and Characterization of a Glucagon-Like Peptide 1-Albumin Conjugate: The Ability to Activate the Glucagon-Like Peptide 1 Receptor In Vivo

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Topics: albumins , blood glucose , glucagon-like peptide 1 , glucose , insulin

Diabetes March 2003, Vol.52, 751-759. doi:https://doi.org/10.2337/diabetes.52.3.751

Role of H1-Calponin in Pancreatic AR42J Cell Differentiation Into Insulin-Producing Cells

Tomoaki Morioka; Hidenori Koyama; Hisako Yamamura; Shinji Tanaka; Shinya Fukumoto; Masanori Emoto; Hiroyuki Mizuguchi; Takao Hayakawa; Itaru Kojima; Katsuhito Takahashi; Yoshiki Nishizawa

Abstracts

View articletitled, Role of H1-Calponin in Pancreatic AR42J Cell Differentiation Into Insulin-Producing Cells

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Topics: activins , calponin , insulin , pancreas , cell differentiation

Diabetes March 2003, Vol.52, 760-766. doi:https://doi.org/10.2337/diabetes.52.3.760

The Insulin Secretory Granule Is the Major Site of K_ATP Channels of the Endocrine Pancreas

Xuehui Geng; Lehong Li; Simon Watkins; Paul D. Robbins; Peter Drain

Abstracts

View articletitled, The Insulin Secretory Granule Is the Major Site of KATP Channels of the Endocrine Pancreas

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Topics: granules , insulin , secretory vesicles , glyburide , endocrine pancreas

Diabetes March 2003, Vol.52, 767-776. doi:https://doi.org/10.2337/diabetes.52.3.767

Pathophysiology

Metallothionein Prevents Diabetes-Induced Deficits in Cardiomyocytes by Inhibiting Reactive Oxygen Species Production

Gang Ye; Naira S. Metreveli; Jun Ren; Paul N. Epstein

Abstracts

View articletitled, Metallothionein Prevents Diabetes-Induced Deficits in Cardiomyocytes by Inhibiting Reactive Oxygen Species Production

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Topics: angiotensin ii , cardiac myocytes , glucose , metallothionein , mice

Diabetes March 2003, Vol.52, 777-783. doi:https://doi.org/10.2337/diabetes.52.3.777

The Focal Form of Persistent Hyperinsulinemic Hypoglycemia of Infancy: Morphological and Molecular Studies Show Structural and Functional Differences With Insulinoma

Christine Sempoux; Yves Guiot; Karin Dahan; Pierre Moulin; Martine Stevens; Virginie Lambot; Pascale de Lonlay; Jean-Christophe Fournet; Claudine Junien; Francis Jaubert; Claire Nihoul-Fekete; Jean-Marie Saudubray; Jacques Rahier

Abstracts

View articletitled, The Focal Form of Persistent Hyperinsulinemic Hypoglycemia of Infancy: Morphological and Molecular Studies Show Structural and Functional Differences With Insulinoma

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Topics: insulin , insulinoma , peptides , insulin-like growth factor ii , proinsulin

Diabetes March 2003, Vol.52, 784-794. doi:https://doi.org/10.2337/diabetes.52.3.784

l-Arginine-Nitric Oxide Kinetics in Normal and Type 2 Diabetic Subjects: A Stable-Labelled ¹⁵N Arginine Approach

Angelo Avogaro; Gianna Toffolo; Edward Kiwanuka; Saula Vigili de Kreutzenberg; Paolo Tessari; Claudio Cobelli

Abstracts

View articletitled, l-Arginine-Nitric Oxide Kinetics in Normal and Type 2 Diabetic Subjects: A Stable-Labelled 15N Arginine Approach

Supplementary data

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Topics: arginine , nitrate

Diabetes March 2003, Vol.52, 795-802. doi:https://doi.org/10.2337/diabetes.52.3.795

Differential Regulation of Lipoprotein Kinetics by Atorvastatin and Fenofibrate in Subjects With the Metabolic Syndrome

Gerald F. Watts; P. Hugh R. Barrett; Juying Ji; Adrian P. Serone; Dick C. Chan; Kevin D. Croft; Franziska Loehrer; Anthony G. Johnson

Abstracts

View articletitled, Differential Regulation of Lipoprotein Kinetics by Atorvastatin and Fenofibrate in Subjects With the Metabolic Syndrome

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Topics: apolipoproteins b , atorvastatin , fenofibrate , high density lipoproteins , lipoproteins

Diabetes March 2003, Vol.52, 803-811. doi:https://doi.org/10.2337/diabetes.52.3.803

Inflammatory Cytokines and the Risk to Develop Type 2 Diabetes: Results of the Prospective Population-Based European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study

Joachim Spranger; Anja Kroke; Matthias Möhlig; Kurt Hoffmann; Manuela M. Bergmann; Michael Ristow; Heiner Boeing; Andreas F.H. Pfeiffer

Abstracts

View articletitled, Inflammatory Cytokines and the Risk to Develop Type 2 Diabetes: Results of the Prospective Population-Based European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study

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Topics: cytokine , diabetes mellitus, type 2 , interleukin-6 , tumor necrosis factors , hemoglobin a, glycosylated

Diabetes March 2003, Vol.52, 812-817. doi:https://doi.org/10.2337/diabetes.52.3.812

Complications

Effect of Reinstitution of Good Glycemic Control on Retinal Oxidative Stress and Nitrative Stress in Diabetic Rats

Renu A. Kowluru

Abstracts

View articletitled, Effect of Reinstitution of Good Glycemic Control on Retinal Oxidative Stress and Nitrative Stress in Diabetic Rats

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Topics: glycemic control , nitric oxide synthase , oxidative stress , rats , retina

Diabetes March 2003, Vol.52, 818-823. doi:https://doi.org/10.2337/diabetes.52.3.818

Latent Transforming Growth Factor-β Binding Protein-1, a Component of Latent Transforming Growth Factor-β Complex, Accelerates the Migration of Aortic Smooth Muscle Cells in Diabetic Rats Through Integrin-β₃

Tetsuto Kanzaki; Masako Otabe

Abstracts

View articletitled, Latent Transforming Growth Factor-β Binding Protein-1, a Component of Latent Transforming Growth Factor-β Complex, Accelerates the Migration of Aortic Smooth Muscle Cells in Diabetic Rats Through Integrin-β3

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Topics: aorta , integrins , platelet-derived growth factor , antibodies

Diabetes March 2003, Vol.52, 824-828. doi:https://doi.org/10.2337/diabetes.52.3.824

Characterization of Retinal Leukostasis and Hemodynamics in Insulin Resistance and Diabetes: Role of Oxidants and Protein Kinase-C Activation

Toru Abiko; Atsuko Abiko; Allen C. Clermont; Brett Shoelson; Naoichi Horio; Junichi Takahashi; Anthony P. Adamis; George L. King; Sven-Erik Bursell

Abstracts

View articletitled, Characterization of Retinal Leukostasis and Hemodynamics in Insulin Resistance and Diabetes: Role of Oxidants and Protein Kinase-C Activation

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Topics: antioxidants , leukocytes , leukostasis , microspheres , rats

Diabetes March 2003, Vol.52, 829-837. doi:https://doi.org/10.2337/diabetes.52.3.829

Role of Protein Kinase C on the Expression of Platelet-Derived Growth Factor and Endothelin-1 in the Retina of Diabetic Rats and Cultured Retinal Capillary Pericytes

Tamotsu Yokota; Ronald C. Ma; Joong-Yeol Park; Keiji Isshiki; Konstantinos B. Sotiropoulos; Ravi K. Rauniyar; Karin E. Bornfeldt; George L. King

Abstracts

View articletitled, Role of Protein Kinase C on the Expression of Platelet-Derived Growth Factor and Endothelin-1 in the Retina of Diabetic Rats and Cultured Retinal Capillary Pericytes

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Topics: endothelin-1 , platelet-derived growth factor , retina , rna, messenger , vascular endothelial growth factor a

Diabetes March 2003, Vol.52, 838-845. doi:https://doi.org/10.2337/diabetes.52.3.838

The Response of Antioxidant Genes to Hyperglycemia Is Abnormal in Patients With Type 1 Diabetes and Diabetic Nephropathy

Andrea D. Hodgkinson; Tracey Bartlett; Peter J. Oates; Beverley A. Millward; Andrew G. Demaine

Abstracts

View articletitled, The Response of Antioxidant Genes to Hyperglycemia Is Abnormal in Patients With Type 1 Diabetes and Diabetic Nephropathy

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Topics: antioxidants , diabetes mellitus, type 1 , diabetic nephropathy , genes , glucose

Diabetes March 2003, Vol.52, 846-851. doi:https://doi.org/10.2337/diabetes.52.3.846

Increased Serum IGF-I During Pregnancy Is Associated With Progression of Diabetic Retinopathy

Finn F. Lauszus; Joachim G. Klebe; Toke Bek; Allan Flyvbjerg

Abstracts

View articletitled, Increased Serum IGF-I During Pregnancy Is Associated With Progression of Diabetic Retinopathy

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Topics: diabetic retinopathy , insulin-like growth factor i , pregnancy , retinal diseases , diabetes mellitus, type 1

Diabetes March 2003, Vol.52, 852-856. doi:https://doi.org/10.2337/diabetes.52.3.852

Enhanced Recombinant Adeno-Associated Virus-Mediated Vascular Endothelial Growth Factor Expression in the Adult Mouse Retina: A Potential Model for Diabetic Retinopathy

P. Elizabeth Rakoczy; Meliha Brankov; Angela Fonceca; Tammy Zaknich; Ben C. Rae; Chooi-May Lai

Abstracts

View articletitled, Enhanced Recombinant Adeno-Associated Virus-Mediated Vascular Endothelial Growth Factor Expression in the Adult Mouse Retina: A Potential Model for Diabetic Retinopathy

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Topics: eye , vascular endothelial growth factor a , diabetic retinopathy

Diabetes March 2003, Vol.52, 857-863. doi:https://doi.org/10.2337/diabetes.52.3.857

Aldose Reductase Inhibitor Fidarestat Prevents Retinal Oxidative Stress and Vascular Endothelial Growth Factor Overexpression in Streptozotocin-Diabetic Rats

Irina G. Obrosova; Alexander G. Minchenko; Rukmini Vasupuram; Lauren White; Omorodola I. Abatan; Arno K. Kumagai; Robert N. Frank; Martin J. Stevens

Abstracts

View articletitled, Aldose Reductase Inhibitor Fidarestat Prevents Retinal Oxidative Stress and Vascular Endothelial Growth Factor Overexpression in Streptozotocin-Diabetic Rats

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Topics: glucose , rats , rna, messenger , vascular endothelial growth factor a , sorbitol

Diabetes March 2003, Vol.52, 864-871. doi:https://doi.org/10.2337/diabetes.52.3.864

Genetics

A Genome-Wide Scan in Families With Maturity-Onset Diabetes of the Young: Evidence for Further Genetic Heterogeneity

Abstracts

View articletitled, A Genome-Wide Scan in Families With Maturity-Onset Diabetes of the Young: Evidence for Further Genetic Heterogeneity

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Topics: genome , maturity onset diabetes mellitus in young

Diabetes March 2003, Vol.52, 872-881. doi:https://doi.org/10.2337/diabetes.52.3.872

Brief Genetics Reports

Insulin Autoantibodies Are Associated With Islet Inflammation But Not Always Related to Diabetes Progression in NOD Congenic Mice

David T. Robles; George S. Eisenbarth; Natalie J.M. Dailey; Laurence B. Peterson; Linda S. Wicker

Abstracts

View articletitled, Insulin Autoantibodies Are Associated With Islet Inflammation But Not Always Related to Diabetes Progression in NOD Congenic Mice

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Topics: autoantibodies , diabetes mellitus, type 1 , inflammation , insulin , mice

Diabetes March 2003, Vol.52, 882-886. doi:https://doi.org/10.2337/diabetes.52.3.882

The Gly⁹⁷²→Arg IRS-1 Variant Is Associated With Type 1 Diabetes in Continental Italy

Massimo Federici; Antonio Petrone; Ottavia Porzio; Carla Bizzarri; Davide Lauro; Rossella D’Alfonso; Ippolita Patera; Marco Cappa; Lorenza Nisticò; Marco Baroni; Giorgio Sesti; Umberto di Mario; Renato Lauro; Raffaella Buzzetti

Abstracts

View articletitled, The Gly972→Arg IRS-1 Variant Is Associated With Type 1 Diabetes in Continental Italy

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Topics: diabetes mellitus, type 1 , irs1 protein, human , italy

Diabetes March 2003, Vol.52, 887-890. doi:https://doi.org/10.2337/diabetes.52.3.887

The Functional −374 T/A RAGE Gene Polymorphism Is Associated With Proteinuria and Cardiovascular Disease in Type 1 Diabetic Patients

Kim Pettersson-Fernholm; Carol Forsblom; Barry I. Hudson; Markus Perola; Peter J. Grant; Per-Henrik Groop; for the FinnDiane Study Group

Abstracts

View articletitled, The Functional −374 T/A RAGE Gene Polymorphism Is Associated With Proteinuria and Cardiovascular Disease in Type 1 Diabetic Patients

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Topics: cardiovascular diseases , genes , polymorphism , proteinuria , rage

Diabetes March 2003, Vol.52, 891-894. doi:https://doi.org/10.2337/diabetes.52.3.891

A Gly482Ser Missense Mutation in the Peroxisome Proliferator-Activated Receptor γ Coactivator-1 Is Associated With Altered Lipid Oxidation and Early Insulin Secretion in Pima Indians

Yunhua Li Muller; Clifton Bogardus; Oluf Pedersen; Leslie Baier

Abstracts

View articletitled, A Gly482Ser Missense Mutation in the Peroxisome Proliferator-Activated Receptor γ Coactivator-1 Is Associated With Altered Lipid Oxidation and Early Insulin Secretion in Pima Indians

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Topics: insulin secretion , lipids , oxidation , peroxisome proliferator-activated receptors , insulin

Diabetes March 2003, Vol.52, 895-898. doi:https://doi.org/10.2337/diabetes.52.3.895

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