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Volume 52, Issue 4

1 April 2003

All Issues

ISSN 0012-1797

EISSN 1939-327X

In this Issue

Perspectives in Diabetes
Metabolism and Signal Transduction
Immunology and Transplantation
Islet Studies
Complications
Genetics
Brief Genetics Reports

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Perspectives in Diabetes

Glucose Allostasis

Michael Stumvoll; P. Antonio Tataranni; Norbert Stefan; Barbora Vozarova; Clifton Bogardus

Abstracts

View articletitled, Glucose Allostasis

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Diabetes April 2003, Vol.52, 903-909. doi:https://doi.org/10.2337/diabetes.52.4.903

Metabolism and Signal Transduction

Human Metabolic Syndrome Resulting From Dominant-Negative Mutations in the Nuclear Receptor Peroxisome Proliferator-Activated Receptor-γ

David B. Savage; Garry D. Tan; Carlo L. Acerini; Susan A. Jebb; Maura Agostini; Mark Gurnell; Rachel L. Williams; A. Margot Umpleby; E. Louise Thomas; Jimmy D. Bell; Adrian K. Dixon; Fidelma Dunne; Romina Boiani; Saverio Cinti; Antonio Vidal-Puig; Fredrik Karpe; V. Krishna K. Chatterjee; Stephen O’Rahilly

Abstracts

View articletitled, Human Metabolic Syndrome Resulting From Dominant-Negative Mutations in the Nuclear Receptor Peroxisome Proliferator-Activated Receptor-γ

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Diabetes April 2003, Vol.52, 910-917. doi:https://doi.org/10.2337/diabetes.52.4.910

Mechanisms for the Deterioration in Glucose Tolerance Associated With HIV Protease Inhibitor Regimens

Hans J. Woerle; Peter R. Mariuz; Christian Meyer; Richard C. Reichman; Emilia M. Popa; Jean M. Dostou; Stephen L. Welle; John E. Gerich

Abstracts

View articletitled, Mechanisms for the Deterioration in Glucose Tolerance Associated With HIV Protease Inhibitor Regimens

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Diabetes April 2003, Vol.52, 918-925. doi:https://doi.org/10.2337/diabetes.52.4.918

Exercise Increases Nuclear AMPK α₂ in Human Skeletal Muscle

Sean L. McGee; Kirsten F. Howlett; Rebecca L. Starkie; David Cameron-Smith; Bruce E. Kemp; Mark Hargreaves

Abstracts

View articletitled, Exercise Increases Nuclear AMPK α2 in Human Skeletal Muscle

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Diabetes April 2003, Vol.52, 926-928. doi:https://doi.org/10.2337/diabetes.52.4.926

Elevation in Tanis Expression Alters Glucose Metabolism and Insulin Sensitivity in H4IIE Cells

Yuan Gao; Ken Walder; Terry Sunderland; Lakshmi Kantham; Helen C. Feng; Melissa Quick; Natalie Bishara; Andrea de Silva; Guy Augert; Janette Tenne-Brown; Gregory R. Collier

Abstracts

View articletitled, Elevation in Tanis Expression Alters Glucose Metabolism and Insulin Sensitivity in H4IIE Cells

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Diabetes April 2003, Vol.52, 929-934. doi:https://doi.org/10.2337/diabetes.52.4.929

Defective Signaling Through Akt-2 and -3 But Not Akt-1 in Insulin-Resistant Human Skeletal Muscle: Potential Role in Insulin Resistance

Joseph T. Brozinick, Jr; Brian R. Roberts; G. Lynis Dohm

Abstracts

View articletitled, Defective Signaling Through Akt-2 and -3 But Not Akt-1 in Insulin-Resistant Human Skeletal Muscle: Potential Role in Insulin Resistance

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Diabetes April 2003, Vol.52, 935-941. doi:https://doi.org/10.2337/diabetes.52.4.935

Association Between Adiponectin and Mediators of Inflammation in Obese Women

Stefan Engeli; Mareike Feldpausch; Kerstin Gorzelniak; Frauke Hartwig; Ute Heintze; Jürgen Janke; Matthias Möhlig; Andreas F.H. Pfeiffer; Friedrich C. Luft; Arya M. Sharma

Abstracts

View articletitled, Association Between Adiponectin and Mediators of Inflammation in Obese Women

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Diabetes April 2003, Vol.52, 942-947. doi:https://doi.org/10.2337/diabetes.52.4.942

Ghrelin Directly Interacts With Neuropeptide-Y-Containing Neurons in the Rat Arcuate Nucleus: Ca²⁺ Signaling via Protein Kinase A and N-Type Channel-Dependent Mechanisms and Cross-Talk With Leptin and Orexin

Daisuke Kohno; Hong-Zhi Gao; Shinji Muroya; Sakae Kikuyama; Toshihiko Yada

Abstracts

View articletitled, Ghrelin Directly Interacts With Neuropeptide-Y-Containing Neurons in the Rat Arcuate Nucleus: Ca2+ Signaling via Protein Kinase A and N-Type Channel-Dependent Mechanisms and Cross-Talk With Leptin and Orexin

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Diabetes April 2003, Vol.52, 948-956. doi:https://doi.org/10.2337/diabetes.52.4.948

Immunology and Transplantation

Prolonged Islet Allograft Survival in Diabetic NOD Mice by Targeting CD45RB and CD154

R. Damaris Molano; Antonello Pileggi; Thierry Berney; Raffaella Poggioli; Elsie Zahr; Robert Oliver; Camillo Ricordi; David M. Rothstein; Giacomo P. Basadonna; Luca Inverardi

Abstracts

View articletitled, Prolonged Islet Allograft Survival in Diabetic NOD Mice by Targeting CD45RB and CD154

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Diabetes April 2003, Vol.52, 957-964. doi:https://doi.org/10.2337/diabetes.52.4.957

Islet Studies

Inhibition of Mitochondrial Na⁺-Ca²⁺ Exchanger Increases Mitochondrial Metabolism and Potentiates Glucose-Stimulated Insulin Secretion in Rat Pancreatic Islets

Bumsup Lee; Philip D. Miles; Leonardo Vargas; Peng Luan; Susan Glasco; Yulia Kushnareva; Elisabeth S. Kornbrust; Kathryn A. Grako; Claes B. Wollheim; Pierre Maechler; Jerrold M. Olefsky; Christen M. Anderson

Abstracts

View articletitled, Inhibition of Mitochondrial Na+-Ca2+ Exchanger Increases Mitochondrial Metabolism and Potentiates Glucose-Stimulated Insulin Secretion in Rat Pancreatic Islets

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Diabetes April 2003, Vol.52, 965-973. doi:https://doi.org/10.2337/diabetes.52.4.965

Differential Activation Mechanisms of Erk-1/2 and p70^S6K by Glucose in Pancreatic β-Cells

Isabelle Briaud; Melissa K. Lingohr; Lorna M. Dickson; Christian E. Wrede; Christopher J. Rhodes

Abstracts

View articletitled, Differential Activation Mechanisms of Erk-1/2 and p70S6K by Glucose in Pancreatic β-Cells

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Diabetes April 2003, Vol.52, 974-983. doi:https://doi.org/10.2337/diabetes.52.4.974

Programming of Islet Functions in the Progeny of Hyperinsulinemic/Obese Rats

Malathi Srinivasan; Ravikumar Aalinkeel; Fei Song; Mulchand S. Patel

Abstracts

View articletitled, Programming of Islet Functions in the Progeny of Hyperinsulinemic/Obese Rats

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Diabetes April 2003, Vol.52, 984-990. doi:https://doi.org/10.2337/diabetes.52.4.984

Protein Kinase C δ Activation and Translocation to the Nucleus Are Required for Fatty Acid-Induced Apoptosis of Insulin-Secreting Cells

Katrin Eitel; Harald Staiger; Johannes Rieger; Harald Mischak; Heide Brandhorst; Mathias D. Brendel; Reinhard G. Bretzel; Hans-Ulrich Häring; Monika Kellerer

Abstracts

View articletitled, Protein Kinase C δ Activation and Translocation to the Nucleus Are Required for Fatty Acid-Induced Apoptosis of Insulin-Secreting Cells

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Diabetes April 2003, Vol.52, 991-997. doi:https://doi.org/10.2337/diabetes.52.4.991

Insulin Does Not Mediate Glucose Stimulation of Proinsulin Biosynthesis

Gil Leibowitz; Andrei I. Oprescu; Gökhan Üçkaya; David J. Gross; Erol Cerasi; Nurit Kaiser

Abstracts

View articletitled, Insulin Does Not Mediate Glucose Stimulation of Proinsulin Biosynthesis

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Diabetes April 2003, Vol.52, 998-1003. doi:https://doi.org/10.2337/diabetes.52.4.998

Semicarbazide-Sensitive Amine Oxidase/Vascular Adhesion Protein-1 Activity Exerts an Antidiabetic Action in Goto-Kakizaki Rats

Anna Abella; Luc Marti; Marta Camps; Marc Claret; J. Fernández-Alvarez; Ramon Gomis; Anna Gumà; Nathalie Viguerie; Christian Carpéné; Manuel Palacín; Xavier Testar; Antonio Zorzano

Abstracts

View articletitled, Semicarbazide-Sensitive Amine Oxidase/Vascular Adhesion Protein-1 Activity Exerts an Antidiabetic Action in Goto-Kakizaki Rats

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Diabetes April 2003, Vol.52, 1004-1013. doi:https://doi.org/10.2337/diabetes.52.4.1004

Complications

Diabetes Can Alter the Signal Transduction Pathways in the Lens of Rats

D. Steven Zatechka, Jr; Peter F. Kador; Sixto Garcia-Castiñeiras; Marjorie F. Lou

Abstracts

View articletitled, Diabetes Can Alter the Signal Transduction Pathways in the Lens of Rats

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Diabetes April 2003, Vol.52, 1014-1022. doi:https://doi.org/10.2337/diabetes.52.4.1014

Nephrin Expression Is Reduced in Human Diabetic Nephropathy: Evidence for a Distinct Role for Glycated Albumin and Angiotensin II

Sophie Doublier; Gennaro Salvidio; Enrico Lupia; Vesa Ruotsalainen; Daniela Verzola; Giacomo Deferrari; Giovanni Camussi

Abstracts

View articletitled, Nephrin Expression Is Reduced in Human Diabetic Nephropathy: Evidence for a Distinct Role for Glycated Albumin and Angiotensin II

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Diabetes April 2003, Vol.52, 1023-1030. doi:https://doi.org/10.2337/diabetes.52.4.1023

Is Podocyte Injury Relevant in Diabetic Nephropathy?: Studies in Patients With Type 2 Diabetes

Michele Dalla Vestra; Alessandra Masiero; Anna Maria Roiter; Alois Saller; Gaetano Crepaldi; Paola Fioretto

Abstracts

View articletitled, Is Podocyte Injury Relevant in Diabetic Nephropathy?: Studies in Patients With Type 2 Diabetes

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Diabetes April 2003, Vol.52, 1031-1035. doi:https://doi.org/10.2337/diabetes.52.4.1031

Low Glomerular Filtration Rate in Normoalbuminuric Type 1 Diabetic Patients: An Indicator of More Advanced Glomerular Lesions

M. Luiza Caramori; Paola Fioretto; Michael Mauer

Abstracts

View articletitled, Low Glomerular Filtration Rate in Normoalbuminuric Type 1 Diabetic Patients: An Indicator of More Advanced Glomerular Lesions

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Diabetes April 2003, Vol.52, 1036-1040. doi:https://doi.org/10.2337/diabetes.52.4.1036

Evaluation of Autofluorescent Property of Hemoglobin-Advanced Glycation End Product as a Long-Term Glycemic Index of Diabetes

Bijukumar Gopalkrishnapillai; Vigneshwaran Nadanathangam; Nivedita Karmakar; Sneh Anand; Anoop Misra

Abstracts

View articletitled, Evaluation of Autofluorescent Property of Hemoglobin-Advanced Glycation End Product as a Long-Term Glycemic Index of Diabetes

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Diabetes April 2003, Vol.52, 1041-1046. doi:https://doi.org/10.2337/diabetes.52.4.1041

Genetics

Using Genetic Admixture to Explain Racial Differences in Insulin-Related Phenotypes

Barbara A. Gower; José R. Fernández; T. Mark Beasley; Mark D. Shriver; Michael I. Goran

Abstracts

View articletitled, Using Genetic Admixture to Explain Racial Differences in Insulin-Related Phenotypes

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Diabetes April 2003, Vol.52, 1047-1051. doi:https://doi.org/10.2337/diabetes.52.4.1047

Brief Genetics Reports

Genetic Liability of Type 1 Diabetes and the Onset Age Among 22,650 Young Finnish Twin Pairs: A Nationwide Follow-Up Study

Valma Hyttinen; Jaakko Kaprio; Leena Kinnunen; Markku Koskenvuo; Jaakko Tuomilehto

Abstracts

View articletitled, Genetic Liability of Type 1 Diabetes and the Onset Age Among 22,650 Young Finnish Twin Pairs: A Nationwide Follow-Up Study

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Diabetes April 2003, Vol.52, 1052-1055. doi:https://doi.org/10.2337/diabetes.52.4.1052

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Perspectives in Diabetes

Glucose Allostasis

Metabolism and Signal Transduction

Human Metabolic Syndrome Resulting From Dominant-Negative Mutations in the Nuclear Receptor Peroxisome Proliferator-Activated Receptor-γ

Mechanisms for the Deterioration in Glucose Tolerance Associated With HIV Protease Inhibitor Regimens

Exercise Increases Nuclear AMPK α₂ in Human Skeletal Muscle

Elevation in Tanis Expression Alters Glucose Metabolism and Insulin Sensitivity in H4IIE Cells

Defective Signaling Through Akt-2 and -3 But Not Akt-1 in Insulin-Resistant Human Skeletal Muscle: Potential Role in Insulin Resistance

Association Between Adiponectin and Mediators of Inflammation in Obese Women

Ghrelin Directly Interacts With Neuropeptide-Y-Containing Neurons in the Rat Arcuate Nucleus: Ca²⁺ Signaling via Protein Kinase A and N-Type Channel-Dependent Mechanisms and Cross-Talk With Leptin and Orexin

Immunology and Transplantation

Prolonged Islet Allograft Survival in Diabetic NOD Mice by Targeting CD45RB and CD154

Islet Studies

Inhibition of Mitochondrial Na⁺-Ca²⁺ Exchanger Increases Mitochondrial Metabolism and Potentiates Glucose-Stimulated Insulin Secretion in Rat Pancreatic Islets

Differential Activation Mechanisms of Erk-1/2 and p70^S6K by Glucose in Pancreatic β-Cells

Programming of Islet Functions in the Progeny of Hyperinsulinemic/Obese Rats

Protein Kinase C δ Activation and Translocation to the Nucleus Are Required for Fatty Acid-Induced Apoptosis of Insulin-Secreting Cells

Insulin Does Not Mediate Glucose Stimulation of Proinsulin Biosynthesis

Semicarbazide-Sensitive Amine Oxidase/Vascular Adhesion Protein-1 Activity Exerts an Antidiabetic Action in Goto-Kakizaki Rats

Complications

Diabetes Can Alter the Signal Transduction Pathways in the Lens of Rats

Nephrin Expression Is Reduced in Human Diabetic Nephropathy: Evidence for a Distinct Role for Glycated Albumin and Angiotensin II

Is Podocyte Injury Relevant in Diabetic Nephropathy?: Studies in Patients With Type 2 Diabetes

Low Glomerular Filtration Rate in Normoalbuminuric Type 1 Diabetic Patients: An Indicator of More Advanced Glomerular Lesions

Evaluation of Autofluorescent Property of Hemoglobin-Advanced Glycation End Product as a Long-Term Glycemic Index of Diabetes

Genetics

Using Genetic Admixture to Explain Racial Differences in Insulin-Related Phenotypes

Brief Genetics Reports

Genetic Liability of Type 1 Diabetes and the Onset Age Among 22,650 Young Finnish Twin Pairs: A Nationwide Follow-Up Study

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Perspectives in Diabetes

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Islet Studies

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