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Issues
1 August 2003
ISSN 0012-1797
EISSN 1939-327X
Metabolism
Effect of Training on Muscle Triacylglycerol and Structural Lipids: A Relation to Insulin Sensitivity?
Diabetes August 2003, Vol.52, 1881-1887. doi:https://doi.org/10.2337/diabetes.52.8.1881
Impact of Aerobic Exercise Training on Age-Related Changes in Insulin Sensitivity and Muscle Oxidative Capacity
Kevin R. Short; Janet L. Vittone; Maureen L. Bigelow; David N. Proctor; Robert A. Rizza; Jill M. Coenen-Schimke; K. Sreekumaran Nair
Diabetes August 2003, Vol.52, 1888-1896. doi:https://doi.org/10.2337/diabetes.52.8.1888
Interaction of Insulin and Prior Exercise in Control of Hepatic Metabolism of a Glucose Load
R. Richard Pencek; Freyja James; D. Brooks Lacy; Kareem Jabbour; Phillip E. Williams; Patrick T. Fueger; David H. Wasserman
Diabetes August 2003, Vol.52, 1897-1903. doi:https://doi.org/10.2337/diabetes.52.8.1897
Signal Transduction
Chronic Endothelin-1 Treatment Leads to Insulin Resistance In Vivo
Diabetes August 2003, Vol.52, 1904-1909. doi:https://doi.org/10.2337/diabetes.52.8.1904
Insulin Resistance in Tetracycline-Repressible Munc18c Transgenic Mice
Beth A. Spurlin; Rhonda M. Thomas; Angela K. Nevins; Hyo-Jeong Kim; Yoon-Jung Kim; Hye-Lim Noh; Gerald I. Shulman; Jason K. Kim; Debbie C. Thurmond
Diabetes August 2003, Vol.52, 1910-1917. doi:https://doi.org/10.2337/diabetes.52.8.1910
A Peroxovanadium Compound Stimulates Muscle Glucose Transport as Powerfully as Insulin and Contractions Combined
Diabetes August 2003, Vol.52, 1918-1925. doi:https://doi.org/10.2337/diabetes.52.8.1918
Activation of Protein Kinase C-ζ by Insulin and Phosphatidylinositol-3,4,5-(PO4)3 Is Defective in Muscle in Type 2 Diabetes and Impaired Glucose Tolerance: Amelioration by Rosiglitazone and Exercise
Mary Beeson; Mini P. Sajan; Michelle Dizon; Dmitry Grebenev; Joaquin Gomez-Daspet; Atsushi Miura; Yoshinori Kanoh; Jennifer Powe; Gautam Bandyopadhyay; Mary L. Standaert; Robert V. Farese
Diabetes August 2003, Vol.52, 1926-1934. doi:https://doi.org/10.2337/diabetes.52.8.1926
Rosiglitazone Improves Downstream Insulin Receptor Signaling in Type 2 Diabetic Patients
Diabetes August 2003, Vol.52, 1943-1950. doi:https://doi.org/10.2337/diabetes.52.8.1943
Obesity
Variation in Type 2 Diabetes-Related Traits in Mouse Strains Susceptible to Diet-Induced Obesity
Diabetes August 2003, Vol.52, 1958-1966. doi:https://doi.org/10.2337/diabetes.52.8.1958
Immunology
Blockade of Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Exacerbates Type 1 Diabetes in NOD Mice
Qing-Sheng Mi; Dalam Ly; S.-E. Lamhamedi-Cherradi; Konstantin V. Salojin; Li Zhou; Marsha Grattan; Craig Meagher; Peter Zucker; Youhai H. Chen; James Nagle; Dennis Taub; Terry L. Delovitch
Diabetes August 2003, Vol.52, 1967-1975. doi:https://doi.org/10.2337/diabetes.52.8.1967
Prevention of Diabetes in NOD Mice by Administration of Dendritic Cells Deficient in Nuclear Transcription Factor-κB Activity
Linlin Ma; Shiguang Qian; Xiaoyan Liang; Lianfu Wang; Jennifer E. Woodward; Nick Giannoukakis; Paul D. Robbins; Suzanne Bertera; Massimo Trucco; John J. Fung; Lina Lu
Diabetes August 2003, Vol.52, 1976-1985. doi:https://doi.org/10.2337/diabetes.52.8.1976
Islet
Endothelial Differentiation Gene Receptors in Pancreatic Islets and INS-1 Cells
Diabetes August 2003, Vol.52, 1986-1993. doi:https://doi.org/10.2337/diabetes.52.8.1986
Free Radicals and the Pathogenesis of Type 1 Diabetes: β-Cell Cytokine-Mediated Free Radical Generation Via Cyclooxygenase-2
Diabetes August 2003, Vol.52, 1994-1999. doi:https://doi.org/10.2337/diabetes.52.8.1994
Small-Conductance Calcium-Activated K+ Channels Are Expressed in Pancreatic Islets and Regulate Glucose Responses
Natalia A. Tamarina; Yong Wang; Loris Mariotto; Andrey Kuznetsov; Chris Bond; John Adelman; Louis H. Philipson
Diabetes August 2003, Vol.52, 2000-2006. doi:https://doi.org/10.2337/diabetes.52.8.2000
Characterization of Endocrine Progenitor Cells and Critical Factors for Their Differentiation in Human Adult Pancreatic Cell Culture
Diabetes August 2003, Vol.52, 2007-2015. doi:https://doi.org/10.2337/diabetes.52.8.2007
Pancreatic Precursors and Differentiated Islet Cell Types From Murine Embryonic Stem Cells: An In Vitro Model to Study Islet Differentiation
Brenda W. Kahan; Lynn M. Jacobson; Debra A. Hullett; Jaime M. Ochoada; Terry D. Oberley; Katharine M. Lang; Jon S. Odorico
Diabetes August 2003, Vol.52, 2016-2024. doi:https://doi.org/10.2337/diabetes.52.8.2016
Diabetogenic Potential of Human Pathogens Uncovered in Experimentally Permissive β-Cells
Diabetes August 2003, Vol.52, 2025-2034. doi:https://doi.org/10.2337/diabetes.52.8.2025
Label-Retaining Cells in the Rat Pancreas: Location and Differentiation Potential in Vitro
Diabetes August 2003, Vol.52, 2035-2042. doi:https://doi.org/10.2337/diabetes.52.8.2035
KATP Channels and Pancreatic Islet Blood Flow in Anesthetized Rats: Increased Blood Flow Induced by Potassium Channel Openers
Diabetes August 2003, Vol.52, 2043-2048. doi:https://doi.org/10.2337/diabetes.52.8.2043
Insulin Constitutively Secreted by β-Cells Is Necessary for Glucose-Stimulated Insulin Secretion
Diabetes August 2003, Vol.52, 2049-2056. doi:https://doi.org/10.2337/diabetes.52.8.2049
Pancreatic β-Cell Lipotoxicity Induced by Overexpression of Hormone-Sensitive Lipase
Maria Sörhede Winzell; Håkan Svensson; Sven Enerbäck; Kim Ravnskjaer; Susanne Mandrup; Victoria Esser; Peter Arner; Marie-Clotilde Alves-Guerra; Bruno Miroux; Frank Sundler; Bo Ahrén; Cecilia Holm
Diabetes August 2003, Vol.52, 2057-2065. doi:https://doi.org/10.2337/diabetes.52.8.2057
Vesicular Inhibitory Amino Acid Transporter Is Present in Glucagon-Containing Secretory Granules in αTC6 Cells, Mouse Clonal α-Cells, and α-Cells of Islets of Langerhans
Mitsuko Hayashi; Masato Otsuka; Riyo Morimoto; Akiko Muroyama; Shunsuke Uehara; Akitsugu Yamamoto; Yoshinori Moriyama
Diabetes August 2003, Vol.52, 2066-2074. doi:https://doi.org/10.2337/diabetes.52.8.2066
Pathophysiology
Vascular Endothelial Function and Blood Pressure Homeostasis in Mice Overexpressing IGF Binding Protein-1
Stephen B. Wheatcroft; Mark T. Kearney; Ajay M. Shah; David J. Grieve; Ian L. Williams; John P. Miell; Paul A. Crossey
Diabetes August 2003, Vol.52, 2075-2082. doi:https://doi.org/10.2337/diabetes.52.8.2075
Cortisol Elevations Comparable to Those That Occur During Hypoglycemia Do Not Cause Hypoglycemia-Associated Autonomic Failure
Diabetes August 2003, Vol.52, 2083-2089. doi:https://doi.org/10.2337/diabetes.52.8.2083
Higher Offspring Birth Weight Predicts the Metabolic Syndrome in Mothers but Not Fathers 8 Years After Delivery: The Pune Children’s Study
Chittaranjan S. Yajnik; Charu V. Joglekar; Anand N. Pandit; Ashish R. Bavdekar; Swati A. Bapat; Sheila A. Bhave; Samantha D. Leary; Caroline H.D. Fall
Diabetes August 2003, Vol.52, 2090-2096. doi:https://doi.org/10.2337/diabetes.52.8.2090
Inflammation-Sensitive Plasma Proteins Are Associated With Future Weight Gain
Diabetes August 2003, Vol.52, 2097-2101. doi:https://doi.org/10.2337/diabetes.52.8.2097
Complications
Prevention of Incipient Diabetic Nephropathy by High-Dose Thiamine and Benfotiamine
Diabetes August 2003, Vol.52, 2110-2120. doi:https://doi.org/10.2337/diabetes.52.8.2110
Leptin Increases Lipoprotein Lipase Secretion by Macrophages: Involvement of Oxidative Stress and Protein Kinase C
Diabetes August 2003, Vol.52, 2121-2128. doi:https://doi.org/10.2337/diabetes.52.8.2121
Insulin Prevents Depolarization of the Mitochondrial Inner Membrane in Sensory Neurons of Type 1 Diabetic Rats in the Presence of Sustained Hyperglycemia
Tze-Jen Huang; Sally A. Price; Lucy Chilton; Nigel A. Calcutt; David R. Tomlinson; Alex Verkhratsky; Paul Fernyhough
Diabetes August 2003, Vol.52, 2129-2136. doi:https://doi.org/10.2337/diabetes.52.8.2129
Genetics
Microarray Analysis of Gene Expression in the Kidneys of New- and Post-Onset Diabetic NOD Mice
Karen H.S. Wilson; Sarah E. Eckenrode; Quan-Zhen Li; Qing-Guo Ruan; Ping Yang; Jing-Da Shi; Abdoreza Davoodi-Semiromi; Richard A. McIndoe; Byron P. Croker; Jin-Xiong She
Diabetes August 2003, Vol.52, 2151-2159. doi:https://doi.org/10.2337/diabetes.52.8.2151
Prevalence and Characteristics of the Metabolic Syndrome in the San Antonio Heart and Framingham Offspring Studies
James B. Meigs; Peter W.F. Wilson; David M. Nathan; Ralph B. D’Agostino, Sr.; Ken Williams; Steven M. Haffner
Diabetes August 2003, Vol.52, 2160-2167. doi:https://doi.org/10.2337/diabetes.52.8.2160
Minimal Model-Based Insulin Sensitivity Has Greater Heritability and a Different Genetic Basis Than Homeostasis Model Assessment or Fasting Insulin
Richard N. Bergman; Daniel J. Zaccaro; Richard M. Watanabe; Steven M. Haffner; Mohammed F. Saad; Jill M. Norris; Lynne E. Wagenknecht; James E. Hokanson; Jerome I. Rotter; Steven S. Rich
Diabetes August 2003, Vol.52, 2168-2174. doi:https://doi.org/10.2337/diabetes.52.8.2168
Identification of Epistatic Interaction Involved in Obesity Using the KK/Ta Mouse as a Type 2 Diabetes Model: Is Zn-α2 Glycoprotein-1 a Candidate Gene for Obesity?
Tomohito Gohda; Yuichiro Makita; Toshihide Shike; Mitsuo Tanimoto; Kazuhiko Funabiki; Satoshi Horikoshi; Yasuhiko Tomino
Diabetes August 2003, Vol.52, 2175-2181. doi:https://doi.org/10.2337/diabetes.52.8.2175
Brief Genetics Report
Genetic Modifiers of the Age at Diagnosis of Diabetes (MODY3) in Carriers of Hepatocyte Nuclear Factor-1α Mutations Map to Chromosomes 5p15, 9q22, and 14q24
Sung-Hoon Kim; Xiaowei Ma; Tomasz Klupa; Christine Powers; Marcus Pezzolesi; James H. Warram; Stephen S. Rich; Andrzej S. Krolewski; Alessandro Doria
Diabetes August 2003, Vol.52, 2182-2186. doi:https://doi.org/10.2337/diabetes.52.8.2182
