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Rapid Publication

Transmission of Maternal Islet Antibodies and Risk of Autoimmune Diabetes in Offspring of Mothers With Type 1 Diabetes

Kerstin Koczwara; Ezio Bonifacio; Anette-Gabriele Ziegler

Abstracts

View articletitled, Transmission of Maternal Islet Antibodies and Risk of Autoimmune Diabetes in Offspring of Mothers With Type 1 Diabetes

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Topics: antibodies , autoantibodies , diabetes mellitus, type 1 , autoimmunity , generalized anxiety disorder

Diabetes January 2004, Vol.53, 1-4. doi:https://doi.org/10.2337/diabetes.53.1.1

Perspectives in Diabetes

Epac: A New cAMP-Binding Protein in Support of Glucagon-Like Peptide-1 Receptor-Mediated Signal Transduction in the Pancreatic β-Cell

George G. Holz

Abstract

View articletitled, Epac: A New cAMP-Binding Protein in Support of Glucagon-Like Peptide-1 Receptor-Mediated Signal Transduction in the Pancreatic β-Cell

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Topics: cyclic amp , exocytosis , glucagon-like peptide 1 , signal transduction , insulin secretion

Diabetes January 2004, Vol.53, 5-13. doi:https://doi.org/10.2337/diabetes.53.1.5

Metabolism

Portal Serotonin Infusion and Glucose Disposal in Conscious Dogs

Mary Courtney Moore; W. Blair Geho; Margaret Lautz; Ben Farmer; Doss W. Neal; Alan D. Cherrington

Abstract

View articletitled, Portal Serotonin Infusion and Glucose Disposal in Conscious Dogs

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Topics: glucose , infusion procedures , serotonin , dog, domestic , glucagon

Diabetes January 2004, Vol.53, 14-20. doi:https://doi.org/10.2337/diabetes.53.1.14

Exercise-Induced Protein Kinase C Isoform-Specific Activation in Human Skeletal Muscle

Sebastio Perrini; Jan Henriksson; Juleen R. Zierath; Ulrika Widegren

Abstract

View articletitled, Exercise-Induced Protein Kinase C Isoform-Specific Activation in Human Skeletal Muscle

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Topics: cytosol , phosphorylation , protein isoforms , protein kinase c , skeletal muscles

Diabetes January 2004, Vol.53, 21-24. doi:https://doi.org/10.2337/diabetes.53.1.21

Ceramide Content Is Increased in Skeletal Muscle From Obese Insulin-Resistant Humans

John M. Adams, II; Thongchai Pratipanawatr; Rachele Berria; Elaine Wang; Ralph A. DeFronzo; M. Cameron Sullards; Lawrence J. Mandarino

Abstract

View articletitled, Ceramide Content Is Increased in Skeletal Muscle From Obese Insulin-Resistant Humans

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Topics: ceramides , insulin , obesity , phosphorylation , proto-oncogene proteins c-akt

Diabetes January 2004, Vol.53, 25-31. doi:https://doi.org/10.2337/diabetes.53.1.25

Nonesterified Fatty Acids and Hepatic Glucose Metabolism in the Conscious Dog

Mary Courtney Moore; Shosuke Satake; Margaret Lautz; Scott A. Soleimanpour; Doss W. Neal; Marta Smith; Alan D. Cherrington

Abstract

View articletitled, Nonesterified Fatty Acids and Hepatic Glucose Metabolism in the Conscious Dog

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Topics: dog, domestic , glucose , nonesterified fatty acids , insulin , glycerol

Diabetes January 2004, Vol.53, 32-40. doi:https://doi.org/10.2337/diabetes.53.1.32

Signal Transduction

Dehydroepiandrosterone Stimulates Glucose Uptake in Human and Murine Adipocytes by Inducing GLUT1 and GLUT4 Translocation to the Plasma Membrane

Sebastio Perrini; Annalisa Natalicchio; Luigi Laviola; Gaetana Belsanti; Carmela Montrone; Angelo Cignarelli; Vincenza Minielli; Maria Grano; Giovanni De Pergola; Riccardo Giorgino; Francesco Giorgino

Abstract

View articletitled, Dehydroepiandrosterone Stimulates Glucose Uptake in Human and Murine Adipocytes by Inducing GLUT1 and GLUT4 Translocation to the Plasma Membrane

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Topics: adipocytes , dehydroepiandrosterone , insulin , glucose transport , translocation (genetics)

Diabetes January 2004, Vol.53, 41-52. doi:https://doi.org/10.2337/diabetes.53.1.41

PKCα Is Activated But Not Required During Glucose-Induced Insulin Secretion From Rat Pancreatic Islets

Lee Carpenter; Christopher J. Mitchell; Zheng Z. Xu; Philip Poronnik; Gerald W. Both; Trevor J. Biden

Abstracts

View articletitled, PKCα Is Activated But Not Required During Glucose-Induced Insulin Secretion From Rat Pancreatic Islets

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Topics: adenoviruses , glucose , insulin secretion , endocrine pancreas , phosphotransferases

Diabetes January 2004, Vol.53, 53-60. doi:https://doi.org/10.2337/diabetes.53.1.53

Islet-Sparing Effects of Protein Tyrosine Phosphatase-1b Deficiency Delays Onset of Diabetes in IRS2 Knockout Mice

Jake A. Kushner; Fawaz G. Haj; Lori D. Klaman; Matthew A. Dow; Barbara B. Kahn; Benjamin G. Neel; Morris F. White

Abstracts

View articletitled, Islet-Sparing Effects of Protein Tyrosine Phosphatase-1b Deficiency Delays Onset of Diabetes in IRS2 Knockout Mice

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Topics: insulin , irs2 protein, human , mice , tyrosine , phosphoric monoester hydrolases

Diabetes January 2004, Vol.53, 61-66. doi:https://doi.org/10.2337/diabetes.53.1.61

Metabolic Pathways That Mediate Inhibition of Hypothalamic Neurons by Glucose

Xue-Jun Yang; Lee-Ming Kow; Donald W. Pfaff; Charles V. Mobbs

Abstract

View articletitled, Metabolic Pathways That Mediate Inhibition of Hypothalamic Neurons by Glucose

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Topics: glucose , neurons , hypothalamus

Diabetes January 2004, Vol.53, 67-73. doi:https://doi.org/10.2337/diabetes.53.1.67

Stimulation of Lipolysis by Tumor Necrosis Factor-α in 3T3-L1 Adipocytes Is Glucose Dependent: Implications for Long-Term Regulation of Lipolysis

Allan Green; John M. Rumberger; Charles A. Stuart; Mary S. Ruhoff

Abstract

View articletitled, Stimulation of Lipolysis by Tumor Necrosis Factor-α in 3T3-L1 Adipocytes Is Glucose Dependent: Implications for Long-Term Regulation of Lipolysis

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Topics: adipocytes , glucose , lipolysis , tumor necrosis factors , lactates

Diabetes January 2004, Vol.53, 74-81. doi:https://doi.org/10.2337/diabetes.53.1.74

Obesity Studies

Responsiveness to Peripherally Administered Melanocortins in Lean and Obese Mice

Susann Blüher; Mary Ziotopoulou; John W. Bullen, Jr; Stergios J. Moschos; Linda Ungsunan; Efi Kokkotou; Eleftheria Maratos-Flier; Christos S. Mantzoros

Abstracts

View articletitled, Responsiveness to Peripherally Administered Melanocortins in Lean and Obese Mice

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Topics: leptin , mice , mice, inbred c57bl , rna, messenger , obesity

Diabetes January 2004, Vol.53, 82-90. doi:https://doi.org/10.2337/diabetes.53.1.82

Immunology and Transplantation

Recruitment of Bone Marrow-Derived Endothelial Cells to Sites of Pancreatic β-Cell Injury

Vikram Mathews; Piia T. Hanson; Eric Ford; Jun Fujita; Kenneth S. Polonsky; Timothy A. Graubert

Abstract

View articletitled, Recruitment of Bone Marrow-Derived Endothelial Cells to Sites of Pancreatic β-Cell Injury

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Topics: donors , pancreas , streptozocin , transplantation , bone marrow cells

Diabetes January 2004, Vol.53, 91-98. doi:https://doi.org/10.2337/diabetes.53.1.91

Caspase-1 Is Not Required for Type 1 Diabetes in the NOD Mouse

William H. Schott; Bradford D. Haskell; Hubert M. Tse; Martha J. Milton; Jon D. Piganelli; Caroline Morgane Choisy-Rossi; Peter C. Reifsnyder; Alexander V. Chervonsky; Edward H. Leiter

Abstract

View articletitled, Caspase-1 Is Not Required for Type 1 Diabetes in the NOD Mouse

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Topics: caspase-1 , interleukin-18 , macrophages , mice , mice, inbred nod

Diabetes January 2004, Vol.53, 99-104. doi:https://doi.org/10.2337/diabetes.53.1.99

Transplantation of Reversibly Immortalized Insulin-Secreting Human Hepatocytes Controls Diabetes in Pancreatectomized Pigs

Teru Okitsu; Naoya Kobayashi; Hee-Sook Jun; Seungjin Shin; Su-Jin Kim; Jaeseok Han; Hyokjoon Kwon; Masakiyo Sakaguchi; Toshinori Totsugawa; Michinori Kohara; Karen A. Westerman; Noriaki Tanaka; Philippe Leboulch; Ji-Won Yoon

Abstract

View articletitled, Transplantation of Reversibly Immortalized Insulin-Secreting Human Hepatocytes Controls Diabetes in Pancreatectomized Pigs

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Topics: hepatocytes , insulin , suidae , glucose , transplantation

Diabetes January 2004, Vol.53, 105-112. doi:https://doi.org/10.2337/diabetes.53.1.105

IL-1 Receptor Deficiency Slows Progression to Diabetes in the NOD Mouse

Helen E. Thomas; Windy Irawaty; Rima Darwiche; Thomas C. Brodnicki; Pere Santamaria; Janette Allison; Thomas W.H. Kay

Abstract

View articletitled, IL-1 Receptor Deficiency Slows Progression to Diabetes in the NOD Mouse

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Topics: cytokine , interleukin-1 , mice , mice, inbred nod , tumor necrosis factors

Diabetes January 2004, Vol.53, 113-121. doi:https://doi.org/10.2337/diabetes.53.1.113

Islet Studies

Inhibition of Lipase Activity and Lipolysis in Rat Islets Reduces Insulin Secretion

Hindrik Mulder; Shumin Yang; Maria Sörhede Winzell; Cecilia Holm; Bo Ahrén

Abstract

View articletitled, Inhibition of Lipase Activity and Lipolysis in Rat Islets Reduces Insulin Secretion

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Topics: adipocytes , glucose , insulin secretion , lipase , lipolysis

Diabetes January 2004, Vol.53, 122-128. doi:https://doi.org/10.2337/diabetes.53.1.122

Gene and Protein Kinase Expression Profiling of Reactive Oxygen Species-Associated Lipotoxicity in the Pancreatic β-Cell Line MIN6

Xiaolin Wang; Hui Li; Domenica De Leo; Wanbei Guo; Vasilij Koshkin; I. George Fantus; Adria Giacca; Catherine B. Chan; Sandy Der; Michael B. Wheeler

Abstracts

View articletitled, Gene and Protein Kinase Expression Profiling of Reactive Oxygen Species-Associated Lipotoxicity in the Pancreatic β-Cell Line MIN6

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Topics: gene expression profiling , genes , glucose , insulin , insulin secretion

Diabetes January 2004, Vol.53, 129-140. doi:https://doi.org/10.2337/diabetes.53.1.129

Role of β-Cell Prohormone Convertase (PC)1/3 in Processing of Pro-Islet Amyloid Polypeptide

Lucy Marzban; Genny Trigo-Gonzalez; Xiaorong Zhu; Christopher J. Rhodes; Philippe A. Halban; Donald F. Steiner; C. Bruce Verchere

Abstract

View articletitled, Role of β-Cell Prohormone Convertase (PC)1/3 in Processing of Pro-Islet Amyloid Polypeptide

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Topics: adenoviruses , amyloid , cytokinesis , iapp gene , immune sera

Diabetes January 2004, Vol.53, 141-148. doi:https://doi.org/10.2337/diabetes.53.1.141

Induction of β-Cell Proliferation and Retinoblastoma Protein Phosphorylation in Rat and Human Islets Using Adenovirus-Mediated Transfer of Cyclin-Dependent Kinase-4 and Cyclin D₁

Irene Cozar-Castellano; Karen K. Takane; Rita Bottino; A.N. Balamurugan; Andrew F. Stewart

Abstract

View articletitled, Induction of β-Cell Proliferation and Retinoblastoma Protein Phosphorylation in Rat and Human Islets Using Adenovirus-Mediated Transfer of Cyclin-Dependent Kinase-4 and Cyclin D1

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Topics: cyclin d1 , retinoblastoma protein , adenoviruses , insulin

Diabetes January 2004, Vol.53, 149-159. doi:https://doi.org/10.2337/diabetes.53.1.149

Pathophysiology

Mode of Onset of Type 2 Diabetes from Normal or Impaired Glucose Tolerance

Ele Ferrannini; Monica Nannipieri; Ken Williams; Clicerio Gonzales; Steve M. Haffner; Michael P. Stern

Abstract

View articletitled, Mode of Onset of Type 2 Diabetes from Normal or Impaired Glucose Tolerance

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Topics: deuterium , diabetes mellitus, type 2 , fasting , follow-up , glucose

Diabetes January 2004, Vol.53, 160-165. doi:https://doi.org/10.2337/diabetes.53.1.160

Complications

Long-Term Renal Effects of a Neutralizing RAGE Antibody in Obese Type 2 Diabetic Mice

Allan Flyvbjerg; Larry Denner; Bieke F. Schrijvers; Ronald G. Tilton; Trine H. Mogensen; Søren R. Paludan; Ruth Rasch

Abstracts

View articletitled, Long-Term Renal Effects of a Neutralizing RAGE Antibody in Obese Type 2 Diabetic Mice

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Topics: antibodies , kidney , mice , rage , kidney glomerulus

Diabetes January 2004, Vol.53, 166-172. doi:https://doi.org/10.2337/diabetes.53.1.166

Regulation of the Early Subnormal Retinal Oxygenation Response in Experimental Diabetes by Inducible Nitric Oxide Synthase

Bruce A. Berkowitz; Hongmei Luan; Rita R. Gupta; Daniel Pacheco; Andres Seidner; Robin Roberts; Jessica Liggett; Deborah L. Knoerzer; Jane R. Connor; Yunpeng Du; Timothy S. Kern; Yasuki Ito

Abstracts

View articletitled, Regulation of the Early Subnormal Retinal Oxygenation Response in Experimental Diabetes by Inducible Nitric Oxide Synthase

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Topics: alveolar ventilation function , cell respiration , diabetes mellitus, experimental , magnetic resonance imaging , mice

Diabetes January 2004, Vol.53, 173-178. doi:https://doi.org/10.2337/diabetes.53.1.173

Retinal Vessel Diameters and the Incidence of Gross Proteinuria and Renal Insufficiency in People With Type 1 Diabetes

Tien Yin Wong; Anoop Shankar; Ronald Klein; Barbara E.K. Klein

Abstract

View articletitled, Retinal Vessel Diameters and the Incidence of Gross Proteinuria and Renal Insufficiency in People With Type 1 Diabetes

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Topics: diabetes mellitus, type 1 , kidney failure , proteinuria , retinal vessels , retinal diseases

Diabetes January 2004, Vol.53, 179-184. doi:https://doi.org/10.2337/diabetes.53.1.179

Elevated Mitochondrial Cytochrome P450 2E1 and Glutathione S-Transferase A4-4 in Streptozotocin-Induced Diabetic Rats: Tissue-Specific Variations and Roles in Oxidative Stress

Haider Raza; Subbuswamy K. Prabu; Mari-Anne Robin; Narayan G. Avadhani

Abstracts

View articletitled, Elevated Mitochondrial Cytochrome P450 2E1 and Glutathione S-Transferase A4-4 in Streptozotocin-Induced Diabetic Rats: Tissue-Specific Variations and Roles in Oxidative Stress

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Topics: cytochrome p-450 cyp2e1 , mitochondria , oxidative stress , streptozocin , rats

Diabetes January 2004, Vol.53, 185-194. doi:https://doi.org/10.2337/diabetes.53.1.185

Endothelial Progenitor Cell Dysfunction: A Novel Concept in the Pathogenesis of Vascular Complications of Type 1 Diabetes

Cindy J.M. Loomans; Eelco J.P. de Koning; Frank J.T. Staal; Maarten B. Rookmaaker; Caroline Verseyden; Hetty C. de Boer; Marianne C. Verhaar; Branko Braam; Ton J. Rabelink; Anton-Jan van Zonneveld

Abstract

View articletitled, Endothelial Progenitor Cell Dysfunction: A Novel Concept in the Pathogenesis of Vascular Complications of Type 1 Diabetes

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Topics: angiogenesis , diabetes mellitus, type 1 , endothelial progenitor cells , hemoglobin a, glycosylated , vascular complications

Diabetes January 2004, Vol.53, 195-199. doi:https://doi.org/10.2337/diabetes.53.1.195

Peroxisome Proliferator-Activated Receptor-γ Ligands Inhibit TGF-β1-Induced Fibronectin Expression in Glomerular Mesangial Cells

Baoliang Guo; Daisuke Koya; Motohide Isono; Toshiro Sugimoto; Atsunori Kashiwagi; Masakazu Haneda

Abstract

View articletitled, Peroxisome Proliferator-Activated Receptor-γ Ligands Inhibit TGF-β1-Induced Fibronectin Expression in Glomerular Mesangial Cells

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Topics: fibronectins , ligands , mesangial cells , peroxisome proliferator-activated receptors , pioglitazone

Diabetes January 2004, Vol.53, 200-208. doi:https://doi.org/10.2337/diabetes.53.1.200

Genetics

Genetic Variation at the Adiponectin Locus and Risk of Type 2 Diabetes in Women

Frank B. Hu; Alessandro Doria; Tricia Li; James B. Meigs; Simin Liu; Asli Memisoglu; David Hunter; JoAnn E. Manson

Abstract

View articletitled, Genetic Variation at the Adiponectin Locus and Risk of Type 2 Diabetes in Women

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Topics: adiponectin , diabetes mellitus, type 2 , obesity , single nucleotide polymorphism , haplotypes

Diabetes January 2004, Vol.53, 209-213. doi:https://doi.org/10.2337/diabetes.53.1.209

Lipoprotein Lipase Is a Gene for Insulin Resistance in Mexican Americans

Mark O. Goodarzi; Xiuqing Guo; Kent D. Taylor; Manuel J. Quiñones; Mohammad F. Saad; Huiying Yang; Willa A. Hsueh; Jerome I. Rotter

Abstract

View articletitled, Lipoprotein Lipase Is a Gene for Insulin Resistance in Mexican Americans

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Topics: fasting , haplotypes , insulin , insulin resistance , insulin sensitivity

Diabetes January 2004, Vol.53, 214-220. doi:https://doi.org/10.2337/diabetes.53.1.214

Familial Hyperinsulinemic Hypoglycemia Caused by a Defect in the SCHAD Enzyme of Mitochondrial Fatty Acid Oxidation

Anders Molven; Guri E. Matre; Marinus Duran; Ronald J. Wanders; Unni Rishaug; Pål R. Njølstad; Egil Jellum; Oddmund Søvik

Abstract

View articletitled, Familial Hyperinsulinemic Hypoglycemia Caused by a Defect in the SCHAD Enzyme of Mitochondrial Fatty Acid Oxidation

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Topics: coenzyme a , enzymes , fatty acid oxidation , genes , homozygote

Diabetes January 2004, Vol.53, 221-227. doi:https://doi.org/10.2337/diabetes.53.1.221

Genome-Wide Search for Type 2 Diabetes/Impaired Glucose Homeostasis Susceptibility Genes in the Chinese: Significant Linkage to Chromosome 6q21-q23 and Chromosome 1q21-q24

Kunsan Xiang; Yanqing Wang; Taishan Zheng; Weiping Jia; Jie Li; Lei Chen; Kunxue Shen; Songhua Wu; Xin Lin; Guodong Zhang; Congrong Wang; Suijun Wang; Huijuan Lu; Qichen Fang; Yi Shi; Rong Zhang; Jing Xu; Qin Weng

Abstracts

View articletitled, Genome-Wide Search for Type 2 Diabetes/Impaired Glucose Homeostasis Susceptibility Genes in the Chinese: Significant Linkage to Chromosome 6q21-q23 and Chromosome 1q21-q24

Supplementary data

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Topics: chromosomes , diabetes mellitus, type 2 , genes , genetic linkage analysis , genetic pedigree

Diabetes January 2004, Vol.53, 228-234. doi:https://doi.org/10.2337/diabetes.53.1.228

Brief Genetics Report

The Common −866 G/A Polymorphism in the Promoter of Uncoupling Protein 2 Is Associated With Increased Carbohydrate and Decreased Lipid Oxidation in Juvenile Obesity

Sophie Le Fur; Catherine Le Stunff; Christine Dos Santos; Pierre Bougnères

Abstract

View articletitled, The Common −866 G/A Polymorphism in the Promoter of Uncoupling Protein 2 Is Associated With Increased Carbohydrate and Decreased Lipid Oxidation in Juvenile Obesity

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Topics: carbohydrates , child , childhood obesity , glucose , lipids

Diabetes January 2004, Vol.53, 235-239. doi:https://doi.org/10.2337/diabetes.53.1.235

Distinguishing Covariation From Causation in Diabetes: A Lesson From the Protein Disulfide Isomerase mRNA Abundance Trait

Hong Lan; Mary E. Rabaglia; Kathryn L. Schueler; Christine Mata; Brian S. Yandell; Alan D. Attie

Abstract

View articletitled, Distinguishing Covariation From Causation in Diabetes: A Lesson From the Protein Disulfide Isomerase mRNA Abundance Trait

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Topics: mice , rna, messenger , protein disulfide isomerase , dna, complementary

Diabetes January 2004, Vol.53, 240-244. doi:https://doi.org/10.2337/diabetes.53.1.240

Identification of Major Quantitative Trait Loci Controlling Body Weight Variation in ob/ob Mice

Jonathan P. Stoehr; Jessica E. Byers; Susanne M. Clee; Hong Lan; Igor V. Boronenkov; Kathryn L. Schueler; Brian S. Yandell; Alan D. Attie

Abstract

View articletitled, Identification of Major Quantitative Trait Loci Controlling Body Weight Variation in ob/ob Mice

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Topics: mice , obesity , quantitative trait loci

Diabetes January 2004, Vol.53, 245-249. doi:https://doi.org/10.2337/diabetes.53.1.245

ADA Workshop Report

C-Peptide Is the Appropriate Outcome Measure for Type 1 Diabetes Clinical Trials to Preserve β-Cell Function : Report of an ADA Workshop, 21–22 October 2001

Jerry P. Palmer; G. Alexander Fleming; Carla J. Greenbaum; Kevan C. Herold; Lisa D. Jansa; Hubert Kolb; John M. Lachin; Kenneth S. Polonsky; Paolo Pozzilli; Jay S. Skyler; Michael W. Steffes

Abstract

View articletitled, C-Peptide Is the Appropriate Outcome Measure for Type 1 Diabetes Clinical Trials to Preserve β-Cell Function : Report of an ADA Workshop, 21–22 October 2001

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Topics: c-peptide , diabetes mellitus, type 1 , insulin , dcct trial , hemoglobin a, glycosylated

Diabetes January 2004, Vol.53, 250-264. doi:https://doi.org/10.2337/diabetes.53.1.250

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