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Perspectives in Diabetes

Molecular Mechanisms of Insulin Resistance That Impact Cardiovascular Biology

Cecilia C. Low Wang; Marc L. Goalstone; Boris Draznin

Abstract

View articletitled, Molecular Mechanisms of Insulin Resistance That Impact Cardiovascular Biology

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Diabetes November 2004, Vol.53, 2735-2740. doi:https://doi.org/10.2337/diabetes.53.11.2735

Metabolism

Physiological Hyperinsulinemia in Dogs Augments Access of Macromolecules to Insulin-Sensitive Tissues

Martin Ellmerer; Stella P. Kim; Marianthe Hamilton-Wessler; Katrin Hücking; Erlinda Kirkman; Richard N. Bergman

Abstract

View articletitled, Physiological Hyperinsulinemia in Dogs Augments Access of Macromolecules to Insulin-Sensitive Tissues

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Diabetes November 2004, Vol.53, 2741-2747. doi:https://doi.org/10.2337/diabetes.53.11.2741

Signal Transduction

Regulation of Peroxisome Proliferator–Activated Receptor-γ Activity by Mammalian Target of Rapamycin and Amino Acids in Adipogenesis

Jae Eun Kim; Jie Chen

Abstract

View articletitled, Regulation of Peroxisome Proliferator–Activated Receptor-γ Activity by Mammalian Target of Rapamycin and Amino Acids in Adipogenesis

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Diabetes November 2004, Vol.53, 2748-2756. doi:https://doi.org/10.2337/diabetes.53.11.2748

CCAAT/Enhancer Binding Protein and Nuclear Factor-Y Regulate Adiponectin Gene Expression in Adipose Tissue

Sang-kyu Park; So-Young Oh; Min-Young Lee; Sarah Yoon; Kyung-Sup Kim; Jae-woo Kim

Abstract

View articletitled, CCAAT/Enhancer Binding Protein and Nuclear Factor-Y Regulate Adiponectin Gene Expression in Adipose Tissue

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Diabetes November 2004, Vol.53, 2757-2766. doi:https://doi.org/10.2337/diabetes.53.11.2757

A New ATP-Sensitive K⁺ Channel–Independent Mechanism Is Involved in Glucose-Excited Neurons of Mouse Arcuate Nucleus

Xavier Fioramonti; Anne Lorsignol; Anne Taupignon; Luc Pénicaud

Abstract

View articletitled, A New ATP-Sensitive K+ Channel–Independent Mechanism Is Involved in Glucose-Excited Neurons of Mouse Arcuate Nucleus

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Diabetes November 2004, Vol.53, 2767-2775. doi:https://doi.org/10.2337/diabetes.53.11.2767

Platelet-Derived Growth Factor Stimulates Glucose Transport in Skeletal Muscles of Transgenic Mice Specifically Expressing Platelet-Derived Growth Factor Receptor in the Muscle, but It Does Not Affect Blood Glucose Levels

Tomoyuki Yuasa; Rei Kakuhata; Kazuhiro Kishi; Toshiyuki Obata; Yasuo Shinohara; Yoshimi Bando; Keisuke Izumi; Fumiko Kajiura; Mitsuru Matsumoto; Yousuke Ebina

Abstract

View articletitled, Platelet-Derived Growth Factor Stimulates Glucose Transport in Skeletal Muscles of Transgenic Mice Specifically Expressing Platelet-Derived Growth Factor Receptor in the Muscle, but It Does Not Affect Blood Glucose Levels

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Diabetes November 2004, Vol.53, 2776-2786. doi:https://doi.org/10.2337/diabetes.53.11.2776

Obesity Study

Ciliary Neurotrophic Factor_Ax15 Alters Energy Homeostasis, Decreases Body Weight, and Improves Metabolic Control in Diet-Induced Obese and UCP1-DTA Mice

Susann Blüher; Stergios Moschos; John Bullen, Jr.; Efi Kokkotou; Eleftheria Maratos-Flier; Stanley J. Wiegand; Mark W. Sleeman; Christos S. Mantzoros

Abstracts

View articletitled, Ciliary Neurotrophic FactorAx15 Alters Energy Homeostasis, Decreases Body Weight, and Improves Metabolic Control in Diet-Induced Obese and UCP1-DTA Mice

Supplementary data

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Diabetes November 2004, Vol.53, 2787-2796. doi:https://doi.org/10.2337/diabetes.53.11.2787

Immunology and Transplantation

Fas Deficiency Prevents Type 1 Diabetes by Inducing Hyporesponsiveness in Islet β-Cell−Reactive T-Cells

Luis Vence; Christophe Benoist; Diane Mathis

Abstracts

View articletitled, Fas Deficiency Prevents Type 1 Diabetes by Inducing Hyporesponsiveness in Islet β-Cell−Reactive T-Cells

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Diabetes November 2004, Vol.53, 2797-2803. doi:https://doi.org/10.2337/diabetes.53.11.2797

Islet Study

Activated Protein C Preserves Functional Islet Mass After Intraportal Transplantation: A Novel Link Between Endothelial Cell Activation, Thrombosis, Inflammation, and Islet Cell Death

Juan L. Contreras; Christopher Eckstein; Cheryl A. Smyth; Guadalupe Bilbao; Mario Vilatoba; Sharman E. Ringland; Carlton Young; J. Anthony Thompson; José A. Fernández; John H. Griffin; Devin E. Eckhoff

Abstract

View articletitled, Activated Protein C Preserves Functional Islet Mass After Intraportal Transplantation: A Novel Link Between Endothelial Cell Activation, Thrombosis, Inflammation, and Islet Cell Death

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Diabetes November 2004, Vol.53, 2804-2814. doi:https://doi.org/10.2337/diabetes.53.11.2804

Intracellular Stress Signaling Pathways Activated During Human Islet Preparation and Following Acute Cytokine Exposure

Saida Abdelli; Jeff Ansite; Raphael Roduit; Tiziana Borsello; Ippei Matsumoto; Toshiya Sawada; Nathalie Allaman-Pillet; Hugues Henry; Jacques S. Beckmann; Bernhard J. Hering; Christophe Bonny

Abstract

View articletitled, Intracellular Stress Signaling Pathways Activated During Human Islet Preparation and Following Acute Cytokine Exposure

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Diabetes November 2004, Vol.53, 2815-2823. doi:https://doi.org/10.2337/diabetes.53.11.2815

Interplay of Glucagon-Like Peptide-1 and Transforming Growth Factor-β Signaling in Insulin-Positive Differentiation of AR42J Cells

Kok-Hooi Yew; Krishna L. Prasadan; Barry L. Preuett; Mark J. Hembree; Christopher R. McFall; Christina L. Benjes; Amanda R. Crowley; Susan L. Sharp; Zhixing Li; Sidhartha S. Tulachan; Sheilendra S. Mehta; George K. Gittes

Abstract

View articletitled, Interplay of Glucagon-Like Peptide-1 and Transforming Growth Factor-β Signaling in Insulin-Positive Differentiation of AR42J Cells

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Diabetes November 2004, Vol.53, 2824-2835. doi:https://doi.org/10.2337/diabetes.53.11.2824

Palmitate Stimulation of Glucagon Secretion in Mouse Pancreatic α-Cells Results From Activation of l-Type Calcium Channels and Elevation of Cytoplasmic Calcium

Charlotta S. Olofsson; Albert Salehi; Sven O. Göpel; Cecilia Holm; Patrik Rorsman

Abstract

View articletitled, Palmitate Stimulation of Glucagon Secretion in Mouse Pancreatic α-Cells Results From Activation of l-Type Calcium Channels and Elevation of Cytoplasmic Calcium

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Diabetes November 2004, Vol.53, 2836-2843. doi:https://doi.org/10.2337/diabetes.53.11.2836

Pioglitazone Reduces Islet Triglyceride Content and Restores Impaired Glucose-Stimulated Insulin Secretion in Heterozygous Peroxisome Proliferator–Activated Receptor-γ–Deficient Mice on a High-Fat Diet

Junji Matsui; Yasuo Terauchi; Naoto Kubota; Iseki Takamoto; Kazuhiro Eto; Tokuyuki Yamashita; Kajuro Komeda; Toshimasa Yamauchi; Junji Kamon; Shunbun Kita; Mitsuhiko Noda; Takashi Kadowaki

Abstracts

View articletitled, Pioglitazone Reduces Islet Triglyceride Content and Restores Impaired Glucose-Stimulated Insulin Secretion in Heterozygous Peroxisome Proliferator–Activated Receptor-γ–Deficient Mice on a High-Fat Diet

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Diabetes November 2004, Vol.53, 2844-2854. doi:https://doi.org/10.2337/diabetes.53.11.2844

Pathophysiology

Elevated Alanine Aminotransferase Predicts New-Onset Type 2 Diabetes Independently of Classical Risk Factors, Metabolic Syndrome, and C-Reactive Protein in the West of Scotland Coronary Prevention Study

Naveed Sattar; Olga Scherbakova; Ian Ford; Denis St. J. O’Reilly; Adrian Stanley; Ewan Forrest; Peter W. MacFarlane; Chris J. Packard; Stuart M. Cobbe; James Shepherd

Abstracts

View articletitled, Elevated Alanine Aminotransferase Predicts New-Onset Type 2 Diabetes Independently of Classical Risk Factors, Metabolic Syndrome, and C-Reactive Protein in the West of Scotland Coronary Prevention Study

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Diabetes November 2004, Vol.53, 2855-2860. doi:https://doi.org/10.2337/diabetes.53.11.2855

A Possible Link Between Skeletal Muscle Mitochondrial Efficiency and Age-Induced Insulin Resistance

Susanna Iossa; Maria Pina Mollica; Lillà Lionetti; Raffaella Crescenzo; Rosaria Tasso; Giovanna Liverini

Abstract

View articletitled, A Possible Link Between Skeletal Muscle Mitochondrial Efficiency and Age-Induced Insulin Resistance

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Diabetes November 2004, Vol.53, 2861-2866. doi:https://doi.org/10.2337/diabetes.53.11.2861

Impact of Intra-Abdominal Fat and Age on Insulin Sensitivity and β-Cell Function

Kristina M. Utzschneider; Darcy B. Carr; Rebecca L. Hull; Keiichi Kodama; Jane B. Shofer; Barbara M. Retzlaff; Robert H. Knopp; Steven E. Kahn

Abstract

View articletitled, Impact of Intra-Abdominal Fat and Age on Insulin Sensitivity and β-Cell Function

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Diabetes November 2004, Vol.53, 2867-2872. doi:https://doi.org/10.2337/diabetes.53.11.2867

Free Fatty Acid Levels Modulate Microvascular Function: Relevance for Obesity-Associated Insulin Resistance, Hypertension, and Microangiopathy

Renate T. de Jongh; Erik H. Serné; Richard G. IJzerman; Greetje de Vries; Coen D.A. Stehouwer

Abstract

View articletitled, Free Fatty Acid Levels Modulate Microvascular Function: Relevance for Obesity-Associated Insulin Resistance, Hypertension, and Microangiopathy

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Diabetes November 2004, Vol.53, 2873-2882. doi:https://doi.org/10.2337/diabetes.53.11.2873

A Prospective Study of Serum Lipids and Risk of Diabetic Macular Edema in Type 1 Diabetes

Biljana Miljanovic; Robert J. Glynn; David M. Nathan; JoAnn E. Manson; Debra A. Schaumberg

Abstract

View articletitled, A Prospective Study of Serum Lipids and Risk of Diabetic Macular Edema in Type 1 Diabetes

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Diabetes November 2004, Vol.53, 2883-2892. doi:https://doi.org/10.2337/diabetes.53.11.2883

Hepatic Lipase mRNA, Protein, and Plasma Enzyme Activity Is Increased in the Insulin-Resistant, Fructose-Fed Syrian Golden Hamster and Is Partially Normalized by the Insulin Sensitizer Rosiglitazone

Gary F. Lewis; Susan Murdoch; Kristine Uffelman; Mark Naples; Linda Szeto; Alegria Albers; Khosrow Adeli; John D. Brunzell

Abstract

View articletitled, Hepatic Lipase mRNA, Protein, and Plasma Enzyme Activity Is Increased in the Insulin-Resistant, Fructose-Fed Syrian Golden Hamster and Is Partially Normalized by the Insulin Sensitizer Rosiglitazone

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Diabetes November 2004, Vol.53, 2893-2900. doi:https://doi.org/10.2337/diabetes.53.11.2893

Phloridzin Improves Hyperglycemia But Not Hepatic Insulin Resistance in a Transgenic Mouse Model of Type 2 Diabetes

Hong Zhao; Shoshana Yakar; Oksana Gavrilova; Hui Sun; Yang Zhang; Hyunsook Kim; Jennifer Setser; William Jou; Derek LeRoith

Abstract

View articletitled, Phloridzin Improves Hyperglycemia But Not Hepatic Insulin Resistance in a Transgenic Mouse Model of Type 2 Diabetes

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Diabetes November 2004, Vol.53, 2901-2909. doi:https://doi.org/10.2337/diabetes.53.11.2901

Complication

Activation of Nulcear Factor-κB by Hyperglycemia in Vascular Smooth Muscle Cells Is Regulated by Aldose Reductase

Kota V. Ramana; Brian Friedrich; Sanjay Srivastava; Aruni Bhatnagar; Satish K. Srivastava

Abstract

View articletitled, Activation of Nulcear Factor-κB by Hyperglycemia in Vascular Smooth Muscle Cells Is Regulated by Aldose Reductase

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Diabetes November 2004, Vol.53, 2910-2920. doi:https://doi.org/10.2337/diabetes.53.11.2910

Attenuation of Extracellular Matrix Accumulation in Diabetic Nephropathy by the Advanced Glycation End Product Cross-Link Breaker ALT-711 via a Protein Kinase C-α−Dependent Pathway

Vicki Thallas-Bonke; Carsten Lindschau; Bishoy Rizkalla; Leon A. Bach; Geoffrey Boner; Matthias Meier; Hermann Haller; Mark E. Cooper; Josephine M. Forbes

Abstract

View articletitled, Attenuation of Extracellular Matrix Accumulation in Diabetic Nephropathy by the Advanced Glycation End Product Cross-Link Breaker ALT-711 via a Protein Kinase C-α−Dependent Pathway

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Diabetes November 2004, Vol.53, 2921-2930. doi:https://doi.org/10.2337/diabetes.53.11.2921

Interactions Between Hyperglycemia and Hypoxia: Implications for Diabetic Retinopathy

Jens R. Nyengaard; Yassuo Ido; Charles Kilo; Joseph R. Williamson

Abstracts

View articletitled, Interactions Between Hyperglycemia and Hypoxia: Implications for Diabetic Retinopathy

Supplementary data

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Diabetes November 2004, Vol.53, 2931-2938. doi:https://doi.org/10.2337/diabetes.53.11.2931

Podocyte-Derived Vascular Endothelial Growth Factor Mediates the Stimulation of α3(IV) Collagen Production by Transforming Growth Factor-β1 in Mouse Podocytes

Sheldon Chen; Yuki Kasama; Joseph S. Lee; Belinda Jim; Maria Marin; Fuad N. Ziyadeh

Abstract

View articletitled, Podocyte-Derived Vascular Endothelial Growth Factor Mediates the Stimulation of α3(IV) Collagen Production by Transforming Growth Factor-β1 in Mouse Podocytes

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Diabetes November 2004, Vol.53, 2939-2949. doi:https://doi.org/10.2337/diabetes.53.11.2939

Leukocyte-Derived Myeloperoxidase Amplifies High-Glucose—Induced Endothelial Dysfunction Through Interaction With High-Glucose—Stimulated, Vascular Non—Leukocyte-Derived Reactive Oxygen Species

Chunxiang Zhang; Jian Yang; Lisa K. Jennings

Abstract

View articletitled, Leukocyte-Derived Myeloperoxidase Amplifies High-Glucose—Induced Endothelial Dysfunction Through Interaction With High-Glucose—Stimulated, Vascular Non—Leukocyte-Derived Reactive Oxygen Species

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Diabetes November 2004, Vol.53, 2950-2959. doi:https://doi.org/10.2337/diabetes.53.11.2950

Poly(ADP-Ribose) Polymerase Is Involved in the Development of Diabetic Retinopathy via Regulation of Nuclear Factor-κB

Ling Zheng; Csaba Szabó; Timothy S. Kern

Abstracts

View articletitled, Poly(ADP-Ribose) Polymerase Is Involved in the Development of Diabetic Retinopathy via Regulation of Nuclear Factor-κB

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Diabetes November 2004, Vol.53, 2960-2967. doi:https://doi.org/10.2337/diabetes.53.11.2960

Tumor Necrosis Factor-α in Diabetic Plasma Increases the Activity of Core 2 GlcNAc-T and Adherence of Human Leukocytes to Retinal Endothelial Cells : Significance of Core 2 GlcNAc-T in Diabetic Retinopathy

Bahaedin M. Ben-Mahmud; Giovanni E. Mann; Alessandro Datti; Aldo Orlacchio; Eva M. Kohner; Rakesh Chibber

Abstract

View articletitled, Tumor Necrosis Factor-α in Diabetic Plasma Increases the Activity of Core 2 GlcNAc-T and Adherence of Human Leukocytes to Retinal Endothelial Cells : Significance of Core 2 GlcNAc-T in Diabetic Retinopathy

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Diabetes November 2004, Vol.53, 2968-2976. doi:https://doi.org/10.2337/diabetes.53.11.2968

Genetic

Genetics of the APM1 Locus and Its Contribution to Type 2 Diabetes Susceptibility in French Caucasians

Fernando Gibson; Philippe Froguel

Abstract

View articletitled, Genetics of the APM1 Locus and Its Contribution to Type 2 Diabetes Susceptibility in French Caucasians

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Diabetes November 2004, Vol.53, 2977-2983. doi:https://doi.org/10.2337/diabetes.53.11.2977

Association of Glomerulopathy With the 5′-End Polymorphism of the Aldose Reductase Gene and Renal Insufficiency in Type 2 Diabetic Patients

Hai-Lu Zhao; Peter C.Y. Tong; Fernand M.M. Lai; Brian Tomlinson; Juliana C.N. Chan

Abstract

View articletitled, Association of Glomerulopathy With the 5′-End Polymorphism of the Aldose Reductase Gene and Renal Insufficiency in Type 2 Diabetic Patients

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Diabetes November 2004, Vol.53, 2984-2991. doi:https://doi.org/10.2337/diabetes.53.11.2984

Brief Genetics Report

Variation in NCB5OR: Studies of Relationships to Type 2 Diabetes, Maturity-Onset Diabetes of the Young, and Gestational Diabetes Mellitus

Gitte Andersen; Lise Wegner; Christian Schack Rose; Jianxin Xie; Hao Zhu; Kevin Larade; Anders Johansen; Jakob Ek; Jeannet Lauenborg; Thomas Drivsholm; Knut Borch-Johnsen; Peter Damm; Torben Hansen; H. Franklin Bunn; Oluf Pedersen

Abstract

View articletitled, Variation in NCB5OR: Studies of Relationships to Type 2 Diabetes, Maturity-Onset Diabetes of the Young, and Gestational Diabetes Mellitus

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Diabetes November 2004, Vol.53, 2992-2997. doi:https://doi.org/10.2337/diabetes.53.11.2992

Activating Mutations in the KCNJ11 Gene Encoding the ATP-Sensitive K⁺ Channel Subunit Kir6.2 Are Rare in Clinically Defined Type 1 Diabetes Diagnosed Before 2 Years

Emma L. Edghill; Anna L. Gloyn; Kathleen M. Gillespie; A. Paul Lambert; Neil T. Raymond; Peter G. Swift; Sian Ellard; Edwin A.M. Gale; Andrew T. Hattersley

Abstracts

View articletitled, Activating Mutations in the KCNJ11 Gene Encoding the ATP-Sensitive K+ Channel Subunit Kir6.2 Are Rare in Clinically Defined Type 1 Diabetes Diagnosed Before 2 Years

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Diabetes November 2004, Vol.53, 2998-3001. doi:https://doi.org/10.2337/diabetes.53.11.2998

Common Variants of the Hepatocyte Nuclear Factor-4α P2 Promoter Are Associated With Type 2 Diabetes in the U.K. Population

Michael N. Weedon; Katharine R. Owen; Beverley Shields; Graham Hitman; Mark Walker; Mark I. McCarthy; Latisha D. Love-Gregory; M. Alan Permutt; Andrew T. Hattersley; Timothy M. Frayling

Abstracts

View articletitled, Common Variants of the Hepatocyte Nuclear Factor-4α P2 Promoter Are Associated With Type 2 Diabetes in the U.K. Population

Supplementary data

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Diabetes November 2004, Vol.53, 3002-3006. doi:https://doi.org/10.2337/diabetes.53.11.3002

Association of Protein Tyrosine Phosphatase 1B Gene Polymorphisms With Type 2 Diabetes

Jennifer L. Bento; Nicholette D. Palmer; Josyf C. Mychaleckyj; Leslie A. Lange; Carl D. Langefeld; Stephen S. Rich; Barry I. Freedman; Donald W. Bowden

Abstracts

View articletitled, Association of Protein Tyrosine Phosphatase 1B Gene Polymorphisms With Type 2 Diabetes

Supplementary data

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Diabetes November 2004, Vol.53, 3007-3012. doi:https://doi.org/10.2337/diabetes.53.11.3007

Association of Protein Tyrosine Phosphatase 1B Gene Polymorphisms With Measures of Glucose Homeostasis in Hispanic Americans: The Insulin Resistance Atherosclerosis Study (IRAS) Family Study

Nicholette D. Palmer; Jennifer L. Bento; Josyf C. Mychaleckyj; Carl D. Langefeld; Joel K. Campbell; Jill M. Norris; Stephen M. Haffner; Richard N. Bergman; Donald W. Bowden

Abstracts

View articletitled, Association of Protein Tyrosine Phosphatase 1B Gene Polymorphisms With Measures of Glucose Homeostasis in Hispanic Americans: The Insulin Resistance Atherosclerosis Study (IRAS) Family Study

Supplementary data

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Diabetes November 2004, Vol.53, 3013-3019. doi:https://doi.org/10.2337/diabetes.53.11.3013

Replication of an Association Between the Lymphoid Tyrosine Phosphatase Locus (LYP/PTPN22) With Type 1 Diabetes, and Evidence for Its Role as a General Autoimmunity Locus

Abstracts

View articletitled, Replication of an Association Between the Lymphoid Tyrosine Phosphatase Locus (LYP/PTPN22) With Type 1 Diabetes, and Evidence for Its Role as a General Autoimmunity Locus

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Diabetes November 2004, Vol.53, 3020-3023. doi:https://doi.org/10.2337/diabetes.53.11.3020

Pharmacology & Therapeutics

Intranasal Insulin Reduces Body Fat in Men but not in Women

Manfred Hallschmid; Christian Benedict; Bernd Schultes; Horst-Lorenz Fehm; Jan Born; Werner Kern

Abstract

View articletitled, Intranasal Insulin Reduces Body Fat in Men but not in Women

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Diabetes November 2004, Vol.53, 3024-3029. doi:https://doi.org/10.2337/diabetes.53.11.3024

Issues

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