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Perspectives in Diabetes

Age-Dependent Influences on the Origins of Autoimmune Diabetes: Evidence and Implications

R. David G. Leslie; Michela Delli Castelli

Extract

View articletitled, Age-Dependent Influences on the Origins of Autoimmune Diabetes: Evidence and Implications

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Topics: autoantibodies , autoimmunity , child , diabetes mellitus, type 1 , insulin

Diabetes December 2004, Vol.53, 3033-3040. doi:https://doi.org/10.2337/diabetes.53.12.3033

Metabolism

Exercise-Induced Changes in Insulin and Glucagon Are Not Required for Enhanced Hepatic Glucose Uptake After Exercise but Influence the Fate of Glucose Within the Liver

R. Richard Pencek; Freyja D. James; D. Brooks Lacy; Kareem Jabbour; Phillip E. Williams; Patrick T. Fueger; David H. Wasserman

Abstracts

View articletitled, Exercise-Induced Changes in Insulin and Glucagon Are Not Required for Enhanced Hepatic Glucose Uptake After Exercise but Influence the Fate of Glucose Within the Liver

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Topics: glucagon , glucose , insulin , liver , liver glycogen

Diabetes December 2004, Vol.53, 3041-3047. doi:https://doi.org/10.2337/diabetes.53.12.3041

Alterations in Postprandial Hepatic Glycogen Metabolism in Type 2 Diabetes

Martin Krssak; Attila Brehm; Elisabeth Bernroider; Christian Anderwald; Peter Nowotny; Chiara Dalla Man; Claudio Cobelli; Gary W. Cline; Gerald I. Shulman; Werner Waldhäusl; Michael Roden

Abstracts

View articletitled, Alterations in Postprandial Hepatic Glycogen Metabolism in Type 2 Diabetes

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Topics: glucose , insulin , liver glycogen , metabolism , postprandial period

Diabetes December 2004, Vol.53, 3048-3056. doi:https://doi.org/10.2337/diabetes.53.12.3048

Signal Transduction

Hepatic PTP-1B Expression Regulates the Assembly and Secretion of Apolipoprotein B–Containing Lipoproteins: Evidence From Protein Tyrosine Phosphatase-1B Overexpression, Knockout, and RNAi Studies

Wei Qiu; Rita Kohen Avramoglu; Nadia Dubé; Taryne M. Chong; Mark Naples; Crystal Au; Konstantinos G. Sidiropoulos; Gary F. Lewis; Jeffrey S. Cohn; Michel L. Tremblay; Khosrow Adeli

Abstracts

View articletitled, Hepatic PTP-1B Expression Regulates the Assembly and Secretion of Apolipoprotein B–Containing Lipoproteins: Evidence From Protein Tyrosine Phosphatase-1B Overexpression, Knockout, and RNAi Studies

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Topics: adenoviruses , apolipoproteins b , bodily secretions , dyslipidemias , fructose

Diabetes December 2004, Vol.53, 3057-3066. doi:https://doi.org/10.2337/diabetes.53.12.3057

LRb-STAT3 Signaling Is Required for the Neuroendocrine Regulation of Energy Expenditure by Leptin

Sarah H. Bates; Trevor A. Dundon; Matthew Seifert; Michael Carlson; Eleftheria Maratos-Flier; Martin G. Myers, Jr

Abstracts

View articletitled, LRb-STAT3 Signaling Is Required for the Neuroendocrine Regulation of Energy Expenditure by Leptin

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Topics: energy metabolism , leptin , mice , neurosecretory systems , signal transduction

Diabetes December 2004, Vol.53, 3067-3073. doi:https://doi.org/10.2337/diabetes.53.12.3067

The α2–5′AMP-Activated Protein Kinase Is a Site 2 Glycogen Synthase Kinase in Skeletal Muscle and Is Responsive to Glucose Loading

Sebastian B. Jørgensen; Jakob N. Nielsen; Jesper B. Birk; Grith Skytte Olsen; Benoit Viollet; Fabrizio Andreelli; Peter Schjerling; Sophie Vaulont; D. Grahame Hardie; Bo F. Hansen; Erik A. Richter; Jørgen F.P. Wojtaszewski

Abstracts

View articletitled, The α2–5′AMP-Activated Protein Kinase Is a Site 2 Glycogen Synthase Kinase in Skeletal Muscle and Is Responsive to Glucose Loading

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Topics: aica ribonucleotide , ampk , glucose , glycogen , mice

Diabetes December 2004, Vol.53, 3074-3081. doi:https://doi.org/10.2337/diabetes.53.12.3074

G-Protein Signaling Participates in the Development of Diabetic Cardiomyopathy

Ian S. Harris; Ilya Treskov; Michael W. Rowley; Scott Heximer; Kevin Kaltenbronn; Brian N. Finck; Richard W. Gross; Daniel P. Kelly; Kendall J. Blumer; Anthony J. Muslin

Abstract

View articletitled, G-Protein Signaling Participates in the Development of Diabetic Cardiomyopathy

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Topics: mice , mice, transgenic , peroxisome proliferator-activated receptors , rgs4 gene , streptozocin

Diabetes December 2004, Vol.53, 3082-3090. doi:https://doi.org/10.2337/diabetes.53.12.3082

Obesity Study

Pancreatic Polypeptide Is Involved in the Regulation of Body Weight in Pima Indian Male Subjects

Juraj Koska; Angelo DelParigi; Barbora de Courten; Christian Weyer; P. Antonio Tataranni

Abstract

View articletitled, Pancreatic Polypeptide Is Involved in the Regulation of Body Weight in Pima Indian Male Subjects

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Topics: fasting , obesity , pancreatic polypeptide , postprandial period , weight gain

Diabetes December 2004, Vol.53, 3091-3096. doi:https://doi.org/10.2337/diabetes.53.12.3091

Fibroblast Growth Factor 1: A Key Regulator of Human Adipogenesis

Louise Hutley; Wenda Shurety; Felicity Newell; Ross McGeary; Nicole Pelton; Jennifer Grant; Adrian Herington; Donald Cameron; Jon Whitehead; Johannes Prins

Abstracts

View articletitled, Fibroblast Growth Factor 1: A Key Regulator of Human Adipogenesis

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Topics: fibroblast growth factor 1 , adipose tissue

Diabetes December 2004, Vol.53, 3097-3106. doi:https://doi.org/10.2337/diabetes.53.12.3097

Immunology and Transplantation

Islet Graft Assessment in the Edmonton Protocol: Implications for Predicting Long-Term Clinical Outcome

Cale N. Street; Jonathan R.T. Lakey; A.M. James Shapiro; Sharleen Imes; Ray V. Rajotte; Edmond A. Ryan; James G. Lyon; Tatsuya Kin; Jose Avila; Toshiaki Tsujimura; Gregory S. Korbutt

Abstract

View articletitled, Islet Graft Assessment in the Edmonton Protocol: Implications for Predicting Long-Term Clinical Outcome

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Topics: insulin , tissue transplants , transplantation

Diabetes December 2004, Vol.53, 3107-3114. doi:https://doi.org/10.2337/diabetes.53.12.3107

Absence of Lymph Nodes in NOD Mice Treated With Lymphotoxin-β Receptor Immunoglobulin Protects From Diabetes

Matteo G. Levisetti; Anish Suri; Katherine Frederick; Emil R. Unanue

Abstracts

View articletitled, Absence of Lymph Nodes in NOD Mice Treated With Lymphotoxin-β Receptor Immunoglobulin Protects From Diabetes

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Topics: immunoglobulins , mice , lymph nodes , mice, inbred nod , antibodies

Diabetes December 2004, Vol.53, 3115-3119. doi:https://doi.org/10.2337/diabetes.53.12.3115

Islet Study

Characterization of Mice Doubly Transgenic for Parathyroid Hormone-Related Protein and Murine Placental Lactogen: A Novel Role for Placental Lactogen in Pancreatic β-Cell Survival

Yuichi Fujinaka; Darinka Sipula; Adolfo Garcia-Ocaña; Rupangi C. Vasavada

Abstract

View articletitled, Characterization of Mice Doubly Transgenic for Parathyroid Hormone-Related Protein and Murine Placental Lactogen: A Novel Role for Placental Lactogen in Pancreatic β-Cell Survival

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Topics: animals, transgenic , insulin , mice , pancreas , parathyroid hormone-related protein

Diabetes December 2004, Vol.53, 3120-3130. doi:https://doi.org/10.2337/diabetes.53.12.3120

Pancreatic-Specific Inactivation of IGF-I Gene Causes Enlarged Pancreatic Islets and Significant Resistance to Diabetes

Yarong Lu; Pedro L. Herrera; Yubin Guo; David Sun; Zhengyi Tang; Derek LeRoith; Jun-Li Liu

Abstract

View articletitled, Pancreatic-Specific Inactivation of IGF-I Gene Causes Enlarged Pancreatic Islets and Significant Resistance to Diabetes

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Topics: endocrine pancreas , insulin , insulin-like growth factor i , mice , pancreas

Diabetes December 2004, Vol.53, 3131-3141. doi:https://doi.org/10.2337/diabetes.53.12.3131

Endogenous Ghrelin in Pancreatic Islets Restricts Insulin Release by Attenuating Ca²⁺ Signaling in β-Cells: Implication in the Glycemic Control in Rodents

Katsuya Dezaki; Hiroshi Hosoda; Masafumi Kakei; Suzuko Hashiguchi; Masatomo Watanabe; Kenji Kangawa; Toshihiko Yada

Abstract

View articletitled, Endogenous Ghrelin in Pancreatic Islets Restricts Insulin Release by Attenuating Ca2+ Signaling in β-Cells: Implication in the Glycemic Control in Rodents

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Topics: ghrelin , insulin , secretagogues , blood glucose , antagonists

Diabetes December 2004, Vol.53, 3142-3151. doi:https://doi.org/10.2337/diabetes.53.12.3142

Massive Augmentation of Stimulated Insulin Secretion Induced by Fatty Acid–Free BSA in Rat Pancreatic Islets

Susanne G. Straub; Geoffrey W. G. Sharp

Abstract

View articletitled, Massive Augmentation of Stimulated Insulin Secretion Induced by Fatty Acid–Free BSA in Rat Pancreatic Islets

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Topics: endocrine pancreas , fatty acids , glucose , insulin , insulin secretion

Diabetes December 2004, Vol.53, 3152-3158. doi:https://doi.org/10.2337/diabetes.53.12.3152

Diet-Induced Glucose Intolerance in Mice With Decreased β-Cell ATP-Sensitive K⁺ Channels

Maria S. Remedi; Joseph. C. Koster; Kamelia Markova; Susumu Seino; Takashi Miki; Brian L. Patton; Michael L. McDaniel; Colin G. Nichols

Abstract

View articletitled, Diet-Induced Glucose Intolerance in Mice With Decreased β-Cell ATP-Sensitive K+ Channels

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Topics: diet , diet, high-fat , glucose , glucose intolerance , insulin

Diabetes December 2004, Vol.53, 3159-3167. doi:https://doi.org/10.2337/diabetes.53.12.3159

High Glucose Is Necessary for Complete Maturation of Pdx1-VP16–Expressing Hepatic Cells into Functional Insulin-Producing Cells

Li-Zhen Cao; Dong-Qi Tang; Marko E. Horb; Shi-Wu Li; Li-Jun Yang

Abstracts

View articletitled, High Glucose Is Necessary for Complete Maturation of Pdx1-VP16–Expressing Hepatic Cells into Functional Insulin-Producing Cells

Supplementary data

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Topics: etoposide , glucose , insulin , pancreas , cell lines

Diabetes December 2004, Vol.53, 3168-3178. doi:https://doi.org/10.2337/diabetes.53.12.3168

Stimulation of Insulin Release by Glucose Is Associated With an Increase in the Number of Docked Granules in the β-Cells of Rat Pancreatic Islets

Susanne G. Straub; Geetha Shanmugam; Geoffrey W.G. Sharp

Abstract

View articletitled, Stimulation of Insulin Release by Glucose Is Associated With an Increase in the Number of Docked Granules in the β-Cells of Rat Pancreatic Islets

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Topics: glucose , granules , insulin

Diabetes December 2004, Vol.53, 3179-3183. doi:https://doi.org/10.2337/diabetes.53.12.3179

Pathophysiology

Insulin Stimulates and Diabetes Inhibits O-Linked N-Acetylglucosamine Transferase and O-Glycosylation of Sp1

Gipsy Majumdar; Jeremiah Wright; Paul Markowitz; Antonio Martinez-Hernandez; Rajendra Raghow; Solomon S. Solomon

Abstract

View articletitled, Insulin Stimulates and Diabetes Inhibits O-Linked N-Acetylglucosamine Transferase and O-Glycosylation of Sp1

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Topics: insulin , glucagon , streptozocin , phosphorylation

Diabetes December 2004, Vol.53, 3184-3192. doi:https://doi.org/10.2337/diabetes.53.12.3184

Phenotypic Characteristics of GAD Antibody-Positive Recently Diagnosed Patients With Type 2 Diabetes in North America and Europe

Bernard Zinman; Steven E. Kahn; Steven M. Haffner; M. Colleen O’Neill; Mark A. Heise; Martin I. Freed; ADOPT Study Group*

Abstracts

View articletitled, Phenotypic Characteristics of GAD Antibody-Positive Recently Diagnosed Patients With Type 2 Diabetes in North America and Europe

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Topics: antibodies , diabetes mellitus, type 2 , generalized anxiety disorder , phenotype , fasting

Diabetes December 2004, Vol.53, 3193-3200. doi:https://doi.org/10.2337/diabetes.53.12.3193

Decreased Sarcoplasmic Reticulum Activity and Contractility in Diabetic db/db Mouse Heart

Darrell D. Belke; Eric A. Swanson; Wolfgang H. Dillmann

Abstract

View articletitled, Decreased Sarcoplasmic Reticulum Activity and Contractility in Diabetic db/db Mouse Heart

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Topics: calcium , heart , mice , muscle cells , sarcoplasmic reticulum

Diabetes December 2004, Vol.53, 3201-3208. doi:https://doi.org/10.2337/diabetes.53.12.3201

Palmitate-Induced Interleukin-6 Expression in Human Coronary Artery Endothelial Cells

Harald Staiger; Katrin Staiger; Norbert Stefan; Hans Günther Wahl; Fausto Machicao; Monika Kellerer; Hans-Ulrich Häring

Abstracts

View articletitled, Palmitate-Induced Interleukin-6 Expression in Human Coronary Artery Endothelial Cells

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Topics: interleukin-6 , palmitates , rna, messenger , coronary artery

Diabetes December 2004, Vol.53, 3209-3216. doi:https://doi.org/10.2337/diabetes.53.12.3209

Complication

Hyperlipidemia in Concert With Hyperglycemia Stimulates the Proliferation of Macrophages in Atherosclerotic Lesions: Potential Role of Glucose-Oxidized LDL

Najib Lamharzi; Catherine B. Renard; Farah Kramer; Subramaniam Pennathur; Jay W. Heinecke; Alan Chait; Karin E. Bornfeldt

Abstracts

View articletitled, Hyperlipidemia in Concert With Hyperglycemia Stimulates the Proliferation of Macrophages in Atherosclerotic Lesions: Potential Role of Glucose-Oxidized LDL

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Topics: glucose , low-density lipoproteins , macrophages , mice , hyperglycemia

Diabetes December 2004, Vol.53, 3217-3225. doi:https://doi.org/10.2337/diabetes.53.12.3217

Hyperglycemia Regulates Hypoxia-Inducible Factor-1α Protein Stability and Function

Sergiu-Bogdan Catrina; Kensaku Okamoto; Teresa Pereira; Kerstin Brismar; Lorenz Poellinger

Abstracts

View articletitled, Hyperglycemia Regulates Hypoxia-Inducible Factor-1α Protein Stability and Function

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Topics: glucose , hyperglycemia , hypoxia , stabilization

Diabetes December 2004, Vol.53, 3226-3232. doi:https://doi.org/10.2337/diabetes.53.12.3226

Effect of Long-Term Administration of α-Lipoic Acid on Retinal Capillary Cell Death and the Development of Retinopathy in Diabetic Rats

Renu A. Kowluru; Sarah Odenbach

Abstract

View articletitled, Effect of Long-Term Administration of α-Lipoic Acid on Retinal Capillary Cell Death and the Development of Retinopathy in Diabetic Rats

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Topics: apoptosis , blood capillaries , diabetic retinopathy , dna , histopathology tests

Diabetes December 2004, Vol.53, 3233-3238. doi:https://doi.org/10.2337/diabetes.53.12.3233

Effects of Polyol Pathway Hyperactivity on Protein Kinase C Activity, Nociceptive Peptide Expression, and Neuronal Structure in Dorsal Root Ganglia in Diabetic Mice

Kenji Uehara; Shin-Ichiro Yamagishi; Saori Otsuki; Shyunsuke Chin; Soroku Yagihashi

Abstract

View articletitled, Effects of Polyol Pathway Hyperactivity on Protein Kinase C Activity, Nociceptive Peptide Expression, and Neuronal Structure in Dorsal Root Ganglia in Diabetic Mice

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Topics: aldehyde reductase , ganglia, spinal , hyperkinesis , mice , mice, transgenic

Diabetes December 2004, Vol.53, 3239-3247. doi:https://doi.org/10.2337/diabetes.53.12.3239

Development of Late-Stage Diabetic Nephropathy in OVE26 Diabetic Mice

Shirong Zheng; William T. Noonan; Naira S. Metreveli; Susan Coventry; Patricia M. Kralik; Edward C. Carlson; Paul N. Epstein

Abstract

View articletitled, Development of Late-Stage Diabetic Nephropathy in OVE26 Diabetic Mice

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Topics: kidney , mice , diabetic nephropathy , albuminuria , blood pressure

Diabetes December 2004, Vol.53, 3248-3257. doi:https://doi.org/10.2337/diabetes.53.12.3248

Pharmacology & Therapeutic

Metformin Prevents the Development of Acute Lipid-Induced Insulin Resistance in the Rat Through Altered Hepatic Signaling Mechanisms

Mark E. Cleasby; Nicolas Dzamko; Bronwyn D. Hegarty; Gregory J. Cooney; Edward W. Kraegen; Ji-Ming Ye

Abstract

View articletitled, Metformin Prevents the Development of Acute Lipid-Induced Insulin Resistance in the Rat Through Altered Hepatic Signaling Mechanisms

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Topics: infusion procedures , insulin resistance , lipids , liver , metformin

Diabetes December 2004, Vol.53, 3258-3266. doi:https://doi.org/10.2337/diabetes.53.12.3258

A Novel Glucagon Receptor Antagonist Inhibits Glucagon-Mediated Biological Effects

Sajjad A. Qureshi; Mari Rios Candelore; Dan Xie; Xiaodong Yang; Laurie M. Tota; Victor D.-H. Ding; Zhihua Li; Alka Bansal; Corin Miller; Sheila M. Cohen; Guoqiang Jiang; Ed Brady; Richard Saperstein; Joseph L. Duffy; James R. Tata; Kevin T. Chapman; David E. Moller; Bei B. Zhang

Abstracts

View articletitled, A Novel Glucagon Receptor Antagonist Inhibits Glucagon-Mediated Biological Effects

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Topics: antagonists , glucagon , glucagon receptors , mice , glucose

Diabetes December 2004, Vol.53, 3267-3273. doi:https://doi.org/10.2337/diabetes.53.12.3267

Genetic

Genetic Determinants of Energy Expenditure and Insulin Resistance in Diet-Induced Obesity in Mice

Katrine Almind; C. Ronald Kahn

Abstracts

View articletitled, Genetic Determinants of Energy Expenditure and Insulin Resistance in Diet-Induced Obesity in Mice

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Topics: diet , diet, high-fat , mice , obesity , weight gain

Diabetes December 2004, Vol.53, 3274-3285. doi:https://doi.org/10.2337/diabetes.53.12.3274

Heterogeneity in the Magnitude of the Insulin Gene Effect on HLA Risk in Type 1 Diabetes

Costantino Motzo; Daniela Contu; Heather J. Cordell; Rosanna Lampis; Mauro Congia; Maria Giovanna Marrosu; John A. Todd; Marcella Devoto; Francesco Cucca

Abstracts

View articletitled, Heterogeneity in the Magnitude of the Insulin Gene Effect on HLA Risk in Type 1 Diabetes

Supplementary data

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Topics: diabetes mellitus, type 1 , genotype , human leukocyte antigens , insulin , heterogeneity

Diabetes December 2004, Vol.53, 3286-3291. doi:https://doi.org/10.2337/diabetes.53.12.3286

Polymorphism in the Calsequestrin 1 (CASQ1) Gene on Chromosome 1q21 Is Associated With Type 2 Diabetes in the Old Order Amish

Mao Fu; Coleen M. Damcott; Mona Sabra; Toni I. Pollin; Sandra H. Ott; Jian Wang; Michael J. Garant; Jeffrey R. O’Connell; Braxton D. Mitchell; Alan R. Shuldiner

Abstracts

View articletitled, Polymorphism in the Calsequestrin 1 (CASQ1) Gene on Chromosome 1q21 Is Associated With Type 2 Diabetes in the Old Order Amish

Supplementary data

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Topics: calsequestrin , diabetes mellitus, type 2 , genes , polymorphism , single nucleotide polymorphism

Diabetes December 2004, Vol.53, 3292-3299. doi:https://doi.org/10.2337/diabetes.53.12.3292

Brief Genetic Report

Calsquestrin 1 (CASQ1) Gene Polymorphisms Under Chromosome 1q21 Linkage Peak Are Associated With Type 2 Diabetes in Northern European Caucasians

Swapan Kumar Das; Winston Chu; Zhengxian Zhang; Sandra J. Hasstedt; Steven C. Elbein

Abstracts

View articletitled, Calsquestrin 1 (CASQ1) Gene Polymorphisms Under Chromosome 1q21 Linkage Peak Are Associated With Type 2 Diabetes in Northern European Caucasians

Supplementary data

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Topics: diabetes mellitus, type 2 , genes , introns , single nucleotide polymorphism , chromosomes

Diabetes December 2004, Vol.53, 3300-3306. doi:https://doi.org/10.2337/diabetes.53.12.3300

Linkage Analysis of Diabetes Status Among Hypertensive Families: The Hypertension Genetic Epidemiology Network Study

Christy L. Avery; Barry I. Freedman; Gerardo Heiss; Aldi Kraja; Treva Rice; Donna Arnett; Michael B. Miller; James S. Pankow; Cora E. Lewis; Richard H. Myers; Steven C. Hunt; Laura Almasy; Kari E. North

Abstracts

View articletitled, Linkage Analysis of Diabetes Status Among Hypertensive Families: The Hypertension Genetic Epidemiology Network Study

Supplementary data

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Topics: diabetes mellitus, type 2 , genetic epidemiology , genetic linkage analysis , hypertension , quantitative trait loci

Diabetes December 2004, Vol.53, 3307-3312. doi:https://doi.org/10.2337/diabetes.53.12.3307

Association Testing in 9,000 People Fails to Confirm the Association of the Insulin Receptor Substrate-1 G972R Polymorphism With Type 2 Diabetes

Jose C. Florez; Marketa Sjögren; Noël Burtt; Marju Orho-Melander; Steve Schayer; Maria Sun; Peter Almgren; Ulf Lindblad; Tiinamaija Tuomi; Daniel Gaudet; Thomas J. Hudson; Mark J. Daly; Kristin G. Ardlie; Joel N. Hirschhorn; David Altshuler; Leif Groop

Abstracts

View articletitled, Association Testing in 9,000 People Fails to Confirm the Association of the Insulin Receptor Substrate-1 G972R Polymorphism With Type 2 Diabetes

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Topics: diabetes mellitus, type 2 , irs1 protein, human , polymorphism , insulin receptor , phenotype

Diabetes December 2004, Vol.53, 3313-3318. doi:https://doi.org/10.2337/diabetes.53.12.3313

Association Studies of Insulin Receptor Substrate 1 Gene (IRS1) Variants in Type 2 Diabetes Samples Enriched for Family History and Early Age of Onset

Eleftheria Zeggini; James Parkinson; Stephanie Halford; Katharine R. Owen; Timothy M. Frayling; Mark Walker; Graham A. Hitman; Jonathan C. Levy; Mike J. Sampson; Edith J.M. Feskens; Andrew T. Hattersley; Mark I. McCarthy

Abstracts

View articletitled, Association Studies of Insulin Receptor Substrate 1 Gene (IRS1) Variants in Type 2 Diabetes Samples Enriched for Family History and Early Age of Onset

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Topics: diabetes mellitus, type 2 , insulin receptor substrate proteins , genes , single nucleotide polymorphism

Diabetes December 2004, Vol.53, 3319-3322. doi:https://doi.org/10.2337/diabetes.53.12.3319

Mapping Non–Class II H2-Linked Loci for Type 1 Diabetes in Nonobese Diabetic Mice

Nathalie Deruytter; Olivier Boulard; Henri-Jean Garchon

Abstract

View articletitled, Mapping Non–Class II H2-Linked Loci for Type 1 Diabetes in Nonobese Diabetic Mice

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Topics: diabetes mellitus, type 1 , mice , mice, inbred nod , delayed hypersensitivity

Diabetes December 2004, Vol.53, 3323-3327. doi:https://doi.org/10.2337/diabetes.53.12.3323

Quantitative Trait Loci for Obesity- and Diabetes-Related Traits and Their Dietary Responses to High-Fat Feeding in LGXSM Recombinant Inbred Mouse Strains

James M. Cheverud; Thomas H. Ehrich; Tomas Hrbek; Jane P. Kenney; L. Susan Pletscher; Clay F. Semenkovich

Abstracts

View articletitled, Quantitative Trait Loci for Obesity- and Diabetes-Related Traits and Their Dietary Responses to High-Fat Feeding in LGXSM Recombinant Inbred Mouse Strains

Supplementary data

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Topics: diet , obesity , quantitative trait loci , leptin , diet, high-fat

Diabetes December 2004, Vol.53, 3328-3336. doi:https://doi.org/10.2337/diabetes.53.12.3328

Polymorphisms in Both Promoters of Hepatocyte Nuclear Factor 4-α Are Associated With Type 2 Diabetes in the Amish

Coleen M. Damcott; Nicole Hoppman; Sandra H. Ott; Laurie J. Reinhart; Jian Wang; Toni I. Pollin; Jeffrey R. O’Connell; Braxton D. Mitchell; Alan R. Shuldiner

Abstract

View articletitled, Polymorphisms in Both Promoters of Hepatocyte Nuclear Factor 4-α Are Associated With Type 2 Diabetes in the Amish

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Topics: diabetes mellitus, type 2 , hepatocytes , oncogenes , oral glucose tolerance test , single nucleotide polymorphism

Diabetes December 2004, Vol.53, 3337-3341. doi:https://doi.org/10.2337/diabetes.53.12.3337

Variation in the Interleukin-6 Receptor Gene Associates With Type 2 Diabetes in Danish Whites

Yasmin H. Hamid; Søren A. Urhammer; Dorit P. Jensen; Charlotte Glümer; Knut Borch-Johnsen; Torben Jørgensen; Torben Hansen; Oluf Pedersen

Abstracts

View articletitled, Variation in the Interleukin-6 Receptor Gene Associates With Type 2 Diabetes in Danish Whites

Supplementary data

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Topics: diabetes mellitus, type 2 , interleukin-6 , genes , obesity , glucose

Diabetes December 2004, Vol.53, 3342-3345. doi:https://doi.org/10.2337/diabetes.53.12.3342

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