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Volume 53, Issue 12
1 December 2004
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ISSN 0012-1797
EISSN 1939-327X
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Perspectives in Diabetes

Age-Dependent Influences on the Origins of Autoimmune Diabetes: Evidence and Implications
R. David G. Leslie; Michela Delli Castelli
View articletitled, Age-Dependent Influences on the Origins of Autoimmune Diabetes<span class="subtitle-colon">: </span><span class="subtitle">Evidence and Implications</span>
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Diabetes December 2004, Vol.53, 3033-3040. doi:https://doi.org/10.2337/diabetes.53.12.3033

Metabolism

Exercise-Induced Changes in Insulin and Glucagon Are Not Required for Enhanced Hepatic Glucose Uptake After Exercise but Influence the Fate of Glucose Within the Liver
R. Richard Pencek; Freyja D. James; D. Brooks Lacy; Kareem Jabbour; Phillip E. Williams; Patrick T. Fueger; David H. Wasserman
View articletitled, Exercise-Induced Changes in Insulin and Glucagon Are Not Required for Enhanced Hepatic Glucose Uptake After Exercise but Influence the Fate of Glucose Within the Liver
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Diabetes December 2004, Vol.53, 3041-3047. doi:https://doi.org/10.2337/diabetes.53.12.3041
Alterations in Postprandial Hepatic Glycogen Metabolism in Type 2 Diabetes
Martin Krssak; Attila Brehm; Elisabeth Bernroider; Christian Anderwald; Peter Nowotny; Chiara Dalla Man; Claudio Cobelli; Gary W. Cline; Gerald I. Shulman; Werner Waldhäusl; Michael Roden
View articletitled, Alterations in Postprandial Hepatic Glycogen Metabolism in Type 2 Diabetes
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Diabetes December 2004, Vol.53, 3048-3056. doi:https://doi.org/10.2337/diabetes.53.12.3048

Signal Transduction

Hepatic PTP-1B Expression Regulates the Assembly and Secretion of Apolipoprotein B–Containing Lipoproteins: Evidence From Protein Tyrosine Phosphatase-1B Overexpression, Knockout, and RNAi Studies
Wei Qiu; Rita Kohen Avramoglu; Nadia Dubé; Taryne M. Chong; Mark Naples; Crystal Au; Konstantinos G. Sidiropoulos; Gary F. Lewis; Jeffrey S. Cohn; Michel L. Tremblay; Khosrow Adeli
View articletitled, Hepatic <em>PTP-1B</em> Expression Regulates the Assembly and Secretion of Apolipoprotein <em>B</em>–Containing Lipoproteins<span class="subtitle-colon">: </span><span class="subtitle">Evidence From Protein Tyrosine Phosphatase-1<em>B</em> Overexpression, Knockout, and <em>RNAi</em> Studies</span>
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Diabetes December 2004, Vol.53, 3057-3066. doi:https://doi.org/10.2337/diabetes.53.12.3057
LRb-STAT3 Signaling Is Required for the Neuroendocrine Regulation of Energy Expenditure by Leptin
Sarah H. Bates; Trevor A. Dundon; Matthew Seifert; Michael Carlson; Eleftheria Maratos-Flier; Martin G. Myers, Jr
View articletitled, LRb-STAT3 Signaling Is Required for the Neuroendocrine Regulation of Energy Expenditure by Leptin
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Diabetes December 2004, Vol.53, 3067-3073. doi:https://doi.org/10.2337/diabetes.53.12.3067
The α2–5′AMP-Activated Protein Kinase Is a Site 2 Glycogen Synthase Kinase in Skeletal Muscle and Is Responsive to Glucose Loading
Sebastian B. Jørgensen; Jakob N. Nielsen; Jesper B. Birk; Grith Skytte Olsen; Benoit Viollet; Fabrizio Andreelli; Peter Schjerling; Sophie Vaulont; D. Grahame Hardie; Bo F. Hansen; Erik A. Richter; Jørgen F.P. Wojtaszewski
View articletitled, The α2–5′AMP-Activated Protein Kinase Is a Site 2 Glycogen Synthase Kinase in Skeletal Muscle and Is Responsive to Glucose Loading
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Diabetes December 2004, Vol.53, 3074-3081. doi:https://doi.org/10.2337/diabetes.53.12.3074
G-Protein Signaling Participates in the Development of Diabetic Cardiomyopathy
Ian S. Harris; Ilya Treskov; Michael W. Rowley; Scott Heximer; Kevin Kaltenbronn; Brian N. Finck; Richard W. Gross; Daniel P. Kelly; Kendall J. Blumer; Anthony J. Muslin
View articletitled, G-Protein Signaling Participates in the Development of Diabetic Cardiomyopathy
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Diabetes December 2004, Vol.53, 3082-3090. doi:https://doi.org/10.2337/diabetes.53.12.3082

Obesity Study

Pancreatic Polypeptide Is Involved in the Regulation of Body Weight in Pima Indian Male Subjects
Juraj Koska; Angelo DelParigi; Barbora de Courten; Christian Weyer; P. Antonio Tataranni
View articletitled, Pancreatic Polypeptide Is Involved in the Regulation of Body Weight in Pima Indian Male Subjects
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Diabetes December 2004, Vol.53, 3091-3096. doi:https://doi.org/10.2337/diabetes.53.12.3091
Fibroblast Growth Factor 1: A Key Regulator of Human Adipogenesis
Louise Hutley; Wenda Shurety; Felicity Newell; Ross McGeary; Nicole Pelton; Jennifer Grant; Adrian Herington; Donald Cameron; Jon Whitehead; Johannes Prins
View articletitled, Fibroblast Growth Factor 1<span class="subtitle-colon">: </span><span class="subtitle">A Key Regulator of Human Adipogenesis</span>
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Diabetes December 2004, Vol.53, 3097-3106. doi:https://doi.org/10.2337/diabetes.53.12.3097

Immunology and Transplantation

Islet Graft Assessment in the Edmonton Protocol: Implications for Predicting Long-Term Clinical Outcome
Cale N. Street; Jonathan R.T. Lakey; A.M. James Shapiro; Sharleen Imes; Ray V. Rajotte; Edmond A. Ryan; James G. Lyon; Tatsuya Kin; Jose Avila; Toshiaki Tsujimura; Gregory S. Korbutt
View articletitled, Islet Graft Assessment in the Edmonton Protocol<span class="subtitle-colon">: </span><span class="subtitle">Implications for Predicting Long-Term Clinical Outcome</span>
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Diabetes December 2004, Vol.53, 3107-3114. doi:https://doi.org/10.2337/diabetes.53.12.3107
Absence of Lymph Nodes in NOD Mice Treated With Lymphotoxin-β Receptor Immunoglobulin Protects From Diabetes
Matteo G. Levisetti; Anish Suri; Katherine Frederick; Emil R. Unanue
View articletitled, Absence of Lymph Nodes in <em>NOD</em> Mice Treated With Lymphotoxin-β Receptor Immunoglobulin Protects From Diabetes
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Diabetes December 2004, Vol.53, 3115-3119. doi:https://doi.org/10.2337/diabetes.53.12.3115

Islet Study

Characterization of Mice Doubly Transgenic for Parathyroid Hormone-Related Protein and Murine Placental Lactogen: A Novel Role for Placental Lactogen in Pancreatic β-Cell Survival
Yuichi Fujinaka; Darinka Sipula; Adolfo Garcia-Ocaña; Rupangi C. Vasavada
View articletitled, Characterization of Mice Doubly Transgenic for Parathyroid Hormone-Related Protein and Murine Placental Lactogen<span class="subtitle-colon">: </span><span class="subtitle">A Novel Role for Placental Lactogen in Pancreatic β-Cell Survival</span>
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Diabetes December 2004, Vol.53, 3120-3130. doi:https://doi.org/10.2337/diabetes.53.12.3120
Pancreatic-Specific Inactivation of IGF-I Gene Causes Enlarged Pancreatic Islets and Significant Resistance to Diabetes
Yarong Lu; Pedro L. Herrera; Yubin Guo; David Sun; Zhengyi Tang; Derek LeRoith; Jun-Li Liu
View articletitled, Pancreatic-Specific Inactivation of IGF-I Gene Causes Enlarged Pancreatic Islets and Significant Resistance to Diabetes
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Diabetes December 2004, Vol.53, 3131-3141. doi:https://doi.org/10.2337/diabetes.53.12.3131
Endogenous Ghrelin in Pancreatic Islets Restricts Insulin Release by Attenuating Ca2+ Signaling in β-Cells: Implication in the Glycemic Control in Rodents
Katsuya Dezaki; Hiroshi Hosoda; Masafumi Kakei; Suzuko Hashiguchi; Masatomo Watanabe; Kenji Kangawa; Toshihiko Yada
View articletitled, Endogenous Ghrelin in Pancreatic Islets Restricts Insulin Release by Attenuating Ca<sup>2+</sup> Signaling in β-Cells<span class="subtitle-colon">: </span><span class="subtitle">Implication in the Glycemic Control in Rodents</span>
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Diabetes December 2004, Vol.53, 3142-3151. doi:https://doi.org/10.2337/diabetes.53.12.3142
Massive Augmentation of Stimulated Insulin Secretion Induced by Fatty Acid–Free BSA in Rat Pancreatic Islets
Susanne G. Straub; Geoffrey W. G. Sharp
View articletitled, Massive Augmentation of Stimulated Insulin Secretion Induced by Fatty Acid–Free BSA in Rat Pancreatic Islets
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Diabetes December 2004, Vol.53, 3152-3158. doi:https://doi.org/10.2337/diabetes.53.12.3152
Diet-Induced Glucose Intolerance in Mice With Decreased β-Cell ATP-Sensitive K+ Channels
Maria S. Remedi; Joseph. C. Koster; Kamelia Markova; Susumu Seino; Takashi Miki; Brian L. Patton; Michael L. McDaniel; Colin G. Nichols
View articletitled, Diet-Induced Glucose Intolerance in Mice With Decreased β-Cell ATP-Sensitive K<sup>+</sup> Channels
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Diabetes December 2004, Vol.53, 3159-3167. doi:https://doi.org/10.2337/diabetes.53.12.3159
High Glucose Is Necessary for Complete Maturation of Pdx1-VP16–Expressing Hepatic Cells into Functional Insulin-Producing Cells
Li-Zhen Cao; Dong-Qi Tang; Marko E. Horb; Shi-Wu Li; Li-Jun Yang
View articletitled, High Glucose Is Necessary for Complete Maturation of Pdx1-VP16–Expressing Hepatic Cells into Functional Insulin-Producing Cells
Supplementary data
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Diabetes December 2004, Vol.53, 3168-3178. doi:https://doi.org/10.2337/diabetes.53.12.3168
Stimulation of Insulin Release by Glucose Is Associated With an Increase in the Number of Docked Granules in the β-Cells of Rat Pancreatic Islets
Susanne G. Straub; Geetha Shanmugam; Geoffrey W.G. Sharp
View articletitled, Stimulation of Insulin Release by Glucose Is Associated With an Increase in the Number of Docked Granules in the β-Cells of Rat Pancreatic Islets
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Diabetes December 2004, Vol.53, 3179-3183. doi:https://doi.org/10.2337/diabetes.53.12.3179

Pathophysiology

Insulin Stimulates and Diabetes Inhibits O-Linked N-Acetylglucosamine Transferase and O-Glycosylation of Sp1
Gipsy Majumdar; Jeremiah Wright; Paul Markowitz; Antonio Martinez-Hernandez; Rajendra Raghow; Solomon S. Solomon
View articletitled, Insulin Stimulates and Diabetes Inhibits O-Linked <em>N</em>-Acetylglucosamine Transferase and O-Glycosylation of Sp1
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Diabetes December 2004, Vol.53, 3184-3192. doi:https://doi.org/10.2337/diabetes.53.12.3184
Phenotypic Characteristics of GAD Antibody-Positive Recently Diagnosed Patients With Type 2 Diabetes in North America and Europe
Bernard Zinman; Steven E. Kahn; Steven M. Haffner; M. Colleen O’Neill; Mark A. Heise; Martin I. Freed; ADOPT Study Group*
View articletitled, Phenotypic Characteristics of GAD Antibody-Positive Recently Diagnosed Patients With Type 2 Diabetes in North America and Europe
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Diabetes December 2004, Vol.53, 3193-3200. doi:https://doi.org/10.2337/diabetes.53.12.3193
Decreased Sarcoplasmic Reticulum Activity and Contractility in Diabetic db/db Mouse Heart
Darrell D. Belke; Eric A. Swanson; Wolfgang H. Dillmann
View articletitled, Decreased Sarcoplasmic Reticulum Activity and Contractility in Diabetic <em>db/db</em> Mouse Heart
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Diabetes December 2004, Vol.53, 3201-3208. doi:https://doi.org/10.2337/diabetes.53.12.3201
Palmitate-Induced Interleukin-6 Expression in Human Coronary Artery Endothelial Cells
Harald Staiger; Katrin Staiger; Norbert Stefan; Hans Günther Wahl; Fausto Machicao; Monika Kellerer; Hans-Ulrich Häring
View articletitled, Palmitate-Induced Interleukin-6 Expression in Human Coronary Artery Endothelial Cells
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Diabetes December 2004, Vol.53, 3209-3216. doi:https://doi.org/10.2337/diabetes.53.12.3209

Complication

Hyperlipidemia in Concert With Hyperglycemia Stimulates the Proliferation of Macrophages in Atherosclerotic Lesions: Potential Role of Glucose-Oxidized LDL
Najib Lamharzi; Catherine B. Renard; Farah Kramer; Subramaniam Pennathur; Jay W. Heinecke; Alan Chait; Karin E. Bornfeldt
View articletitled, Hyperlipidemia in Concert With Hyperglycemia Stimulates the Proliferation of Macrophages in Atherosclerotic Lesions<span class="subtitle-colon">: </span><span class="subtitle">Potential Role of Glucose-Oxidized LDL</span>
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Diabetes December 2004, Vol.53, 3217-3225. doi:https://doi.org/10.2337/diabetes.53.12.3217
Hyperglycemia Regulates Hypoxia-Inducible Factor-1α Protein Stability and Function
Sergiu-Bogdan Catrina; Kensaku Okamoto; Teresa Pereira; Kerstin Brismar; Lorenz Poellinger
View articletitled, Hyperglycemia Regulates Hypoxia-Inducible Factor-1α Protein Stability and Function
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Diabetes December 2004, Vol.53, 3226-3232. doi:https://doi.org/10.2337/diabetes.53.12.3226
Effect of Long-Term Administration of α-Lipoic Acid on Retinal Capillary Cell Death and the Development of Retinopathy in Diabetic Rats
Renu A. Kowluru; Sarah Odenbach
View articletitled, Effect of Long-Term Administration of α-Lipoic Acid on Retinal Capillary Cell Death and the Development of Retinopathy in Diabetic Rats
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Diabetes December 2004, Vol.53, 3233-3238. doi:https://doi.org/10.2337/diabetes.53.12.3233
Effects of Polyol Pathway Hyperactivity on Protein Kinase C Activity, Nociceptive Peptide Expression, and Neuronal Structure in Dorsal Root Ganglia in Diabetic Mice
Kenji Uehara; Shin-Ichiro Yamagishi; Saori Otsuki; Shyunsuke Chin; Soroku Yagihashi
View articletitled, Effects of Polyol Pathway Hyperactivity on Protein Kinase C Activity, Nociceptive Peptide Expression, and Neuronal Structure in Dorsal Root Ganglia in Diabetic Mice
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Diabetes December 2004, Vol.53, 3239-3247. doi:https://doi.org/10.2337/diabetes.53.12.3239
Development of Late-Stage Diabetic Nephropathy in OVE26 Diabetic Mice
Shirong Zheng; William T. Noonan; Naira S. Metreveli; Susan Coventry; Patricia M. Kralik; Edward C. Carlson; Paul N. Epstein
View articletitled, Development of Late-Stage Diabetic Nephropathy in OVE26 Diabetic Mice
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Diabetes December 2004, Vol.53, 3248-3257. doi:https://doi.org/10.2337/diabetes.53.12.3248

Pharmacology & Therapeutic

Metformin Prevents the Development of Acute Lipid-Induced Insulin Resistance in the Rat Through Altered Hepatic Signaling Mechanisms
Mark E. Cleasby; Nicolas Dzamko; Bronwyn D. Hegarty; Gregory J. Cooney; Edward W. Kraegen; Ji-Ming Ye
View articletitled, Metformin Prevents the Development of Acute Lipid-Induced Insulin Resistance in the Rat Through Altered Hepatic Signaling Mechanisms
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Diabetes December 2004, Vol.53, 3258-3266. doi:https://doi.org/10.2337/diabetes.53.12.3258
A Novel Glucagon Receptor Antagonist Inhibits Glucagon-Mediated Biological Effects
Sajjad A. Qureshi; Mari Rios Candelore; Dan Xie; Xiaodong Yang; Laurie M. Tota; Victor D.-H. Ding; Zhihua Li; Alka Bansal; Corin Miller; Sheila M. Cohen; Guoqiang Jiang; Ed Brady; Richard Saperstein; Joseph L. Duffy; James R. Tata; Kevin T. Chapman; David E. Moller; Bei B. Zhang
View articletitled, A Novel Glucagon Receptor Antagonist Inhibits Glucagon-Mediated Biological Effects
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Diabetes December 2004, Vol.53, 3267-3273. doi:https://doi.org/10.2337/diabetes.53.12.3267

Genetic

Genetic Determinants of Energy Expenditure and Insulin Resistance in Diet-Induced Obesity in Mice
Katrine Almind; C. Ronald Kahn
View articletitled, Genetic Determinants of Energy Expenditure and Insulin Resistance in Diet-Induced Obesity in Mice
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Diabetes December 2004, Vol.53, 3274-3285. doi:https://doi.org/10.2337/diabetes.53.12.3274
Heterogeneity in the Magnitude of the Insulin Gene Effect on HLA Risk in Type 1 Diabetes
Costantino Motzo; Daniela Contu; Heather J. Cordell; Rosanna Lampis; Mauro Congia; Maria Giovanna Marrosu; John A. Todd; Marcella Devoto; Francesco Cucca
View articletitled, Heterogeneity in the Magnitude of the Insulin Gene Effect on HLA Risk in Type 1 Diabetes
Supplementary data
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Diabetes December 2004, Vol.53, 3286-3291. doi:https://doi.org/10.2337/diabetes.53.12.3286
Polymorphism in the Calsequestrin 1 (CASQ1) Gene on Chromosome 1q21 Is Associated With Type 2 Diabetes in the Old Order Amish
Mao Fu; Coleen M. Damcott; Mona Sabra; Toni I. Pollin; Sandra H. Ott; Jian Wang; Michael J. Garant; Jeffrey R. O’Connell; Braxton D. Mitchell; Alan R. Shuldiner
View articletitled, Polymorphism in the Calsequestrin 1 (<em>CASQ1</em>) Gene on Chromosome 1q21 Is Associated With Type 2 Diabetes in the Old Order Amish
Supplementary data
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Diabetes December 2004, Vol.53, 3292-3299. doi:https://doi.org/10.2337/diabetes.53.12.3292

Brief Genetic Report

Calsquestrin 1 (CASQ1) Gene Polymorphisms Under Chromosome 1q21 Linkage Peak Are Associated With Type 2 Diabetes in Northern European Caucasians
Swapan Kumar Das; Winston Chu; Zhengxian Zhang; Sandra J. Hasstedt; Steven C. Elbein
View articletitled, Calsquestrin 1 (<em>CASQ1</em>) Gene Polymorphisms Under Chromosome 1q21 Linkage Peak Are Associated With Type 2 Diabetes in Northern European Caucasians
Supplementary data
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Diabetes December 2004, Vol.53, 3300-3306. doi:https://doi.org/10.2337/diabetes.53.12.3300
Linkage Analysis of Diabetes Status Among Hypertensive Families: The Hypertension Genetic Epidemiology Network Study
Christy L. Avery; Barry I. Freedman; Gerardo Heiss; Aldi Kraja; Treva Rice; Donna Arnett; Michael B. Miller; James S. Pankow; Cora E. Lewis; Richard H. Myers; Steven C. Hunt; Laura Almasy; Kari E. North
View articletitled, Linkage Analysis of Diabetes Status Among Hypertensive Families<span class="subtitle-colon">: </span><span class="subtitle">The Hypertension Genetic Epidemiology Network Study</span>
Supplementary data
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Diabetes December 2004, Vol.53, 3307-3312. doi:https://doi.org/10.2337/diabetes.53.12.3307
Association Testing in 9,000 People Fails to Confirm the Association of the Insulin Receptor Substrate-1 G972R Polymorphism With Type 2 Diabetes
Jose C. Florez; Marketa Sjögren; Noël Burtt; Marju Orho-Melander; Steve Schayer; Maria Sun; Peter Almgren; Ulf Lindblad; Tiinamaija Tuomi; Daniel Gaudet; Thomas J. Hudson; Mark J. Daly; Kristin G. Ardlie; Joel N. Hirschhorn; David Altshuler; Leif Groop
View articletitled, Association Testing in 9,000 People Fails to Confirm the Association of the Insulin Receptor Substrate-1 G972R Polymorphism With Type 2 Diabetes
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Diabetes December 2004, Vol.53, 3313-3318. doi:https://doi.org/10.2337/diabetes.53.12.3313
Association Studies of Insulin Receptor Substrate 1 Gene (IRS1) Variants in Type 2 Diabetes Samples Enriched for Family History and Early Age of Onset
Eleftheria Zeggini; James Parkinson; Stephanie Halford; Katharine R. Owen; Timothy M. Frayling; Mark Walker; Graham A. Hitman; Jonathan C. Levy; Mike J. Sampson; Edith J.M. Feskens; Andrew T. Hattersley; Mark I. McCarthy
View articletitled, Association Studies of Insulin Receptor Substrate 1 Gene (<em>IRS1</em>) Variants in Type 2 Diabetes Samples Enriched for Family History and Early Age of Onset
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Diabetes December 2004, Vol.53, 3319-3322. doi:https://doi.org/10.2337/diabetes.53.12.3319
Mapping Non–Class II H2-Linked Loci for Type 1 Diabetes in Nonobese Diabetic Mice
Nathalie Deruytter; Olivier Boulard; Henri-Jean Garchon
View articletitled, Mapping Non–Class II H2-Linked Loci for Type 1 Diabetes in Nonobese Diabetic Mice
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Diabetes December 2004, Vol.53, 3323-3327. doi:https://doi.org/10.2337/diabetes.53.12.3323
Quantitative Trait Loci for Obesity- and Diabetes-Related Traits and Their Dietary Responses to High-Fat Feeding in LGXSM Recombinant Inbred Mouse Strains
James M. Cheverud; Thomas H. Ehrich; Tomas Hrbek; Jane P. Kenney; L. Susan Pletscher; Clay F. Semenkovich
View articletitled, Quantitative Trait Loci for Obesity- and Diabetes-Related Traits and Their Dietary Responses to High-Fat Feeding in LGXSM Recombinant Inbred Mouse Strains
Supplementary data
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Diabetes December 2004, Vol.53, 3328-3336. doi:https://doi.org/10.2337/diabetes.53.12.3328
Polymorphisms in Both Promoters of Hepatocyte Nuclear Factor 4-α Are Associated With Type 2 Diabetes in the Amish
Coleen M. Damcott; Nicole Hoppman; Sandra H. Ott; Laurie J. Reinhart; Jian Wang; Toni I. Pollin; Jeffrey R. O’Connell; Braxton D. Mitchell; Alan R. Shuldiner
View articletitled, Polymorphisms in Both Promoters of Hepatocyte Nuclear Factor 4-α Are Associated With Type 2 Diabetes in the Amish
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Diabetes December 2004, Vol.53, 3337-3341. doi:https://doi.org/10.2337/diabetes.53.12.3337
Variation in the Interleukin-6 Receptor Gene Associates With Type 2 Diabetes in Danish Whites
Yasmin H. Hamid; Søren A. Urhammer; Dorit P. Jensen; Charlotte Glümer; Knut Borch-Johnsen; Torben Jørgensen; Torben Hansen; Oluf Pedersen
View articletitled, Variation in the Interleukin-6 Receptor Gene Associates With Type 2 Diabetes in Danish Whites
Supplementary data
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Diabetes December 2004, Vol.53, 3342-3345. doi:https://doi.org/10.2337/diabetes.53.12.3342
Système International (SI) Units Table
Management of Latent Autoimmune Diabetes in Adults: A Consensus Statement From an International Expert Panel
713-P: Is There a Correct Time to Measure Fasting Blood Sugar in Persons with Type 2 Diabetes Melitus?
300-OR: Beneficial Effect of the Combination Therapy of Cagrilintide, a Dual Amylin/Calcitonin Agonist, and Tirzepatide, a Dual GLP-1/GIP Agonist, on Body Weight Loss in Obese Rats
Elevated First-Trimester Neutrophil Count Is Closely Associated With the Development of Maternal Gestational Diabetes Mellitus and Adverse Pregnancy Outcomes
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