Skip Nav Destination

Issues

Select Decade

Select Year

Issue

Search within issue:

Search within issue

Banting Lecture 2003

Autoimmune Diabetes and the Circle of Tolerance

Aldo A. Rossini

Abstract

View articletitled, Autoimmune Diabetes and the Circle of Tolerance

Open the PDF for in another window

Topics: autoimmunity , diabetes mellitus, type 1 , monoclonal antibodies , t-lymphocytes , islets of langerhans transplantation

Diabetes February 2004, Vol.53, 267-275. doi:https://doi.org/10.2337/diabetes.53.2.267

Perspectives in Diabetes

Chronic Sympathetic Activation: Consequence and Cause of Age-Associated Obesity?

Douglas R. Seals; Christopher Bell

Abstract

View articletitled, Chronic Sympathetic Activation: Consequence and Cause of Age-Associated Obesity?

Open the PDF for in another window

Topics: aging , obesity

Diabetes February 2004, Vol.53, 276-284. doi:https://doi.org/10.2337/diabetes.53.2.276

Metabolism

Suppression of Endogenous Glucose Production by Mild Hyperinsulinemia During Exercise Is Determined Predominantly by Portal Venous Insulin

Raul C. Camacho; R. Richard Pencek; D. Brooks Lacy; Freyja D. James; David H. Wasserman

Abstract

View articletitled, Suppression of Endogenous Glucose Production by Mild Hyperinsulinemia During Exercise Is Determined Predominantly by Portal Venous Insulin

Open the PDF for in another window

Topics: glucagon , glucose , hyperinsulinism , insulin , portal vein

Diabetes February 2004, Vol.53, 285-293. doi:https://doi.org/10.2337/diabetes.53.2.285

Strength Training Increases Insulin-Mediated Glucose Uptake, GLUT4 Content, and Insulin Signaling in Skeletal Muscle in Patients With Type 2 Diabetes

Mads K. Holten; Morten Zacho; Michael Gaster; Carsten Juel; Jørgen F.P. Wojtaszewski; Flemming Dela

Abstract

View articletitled, Strength Training Increases Insulin-Mediated Glucose Uptake, GLUT4 Content, and Insulin Signaling in Skeletal Muscle in Patients With Type 2 Diabetes

Open the PDF for in another window

Topics: diabetes mellitus, type 2 , glucose , insulin , leg , skeletal muscles

Diabetes February 2004, Vol.53, 294-305. doi:https://doi.org/10.2337/diabetes.53.2.294

Hexokinase II Overexpression Improves Exercise-Stimulated But Not Insulin-Stimulated Muscle Glucose Uptake in High-Fat-Fed C57BL/6J Mice

Patrick T. Fueger; Deanna P. Bracy; Carlo M. Malabanan; R. Richard Pencek; Daryl K. Granner; David H. Wasserman

Abstract

View articletitled, Hexokinase II Overexpression Improves Exercise-Stimulated But Not Insulin-Stimulated Muscle Glucose Uptake in High-Fat-Fed C57BL/6J Mice

Open the PDF for in another window

Topics: diet , glucose , insulin , mice , protein overexpression

Diabetes February 2004, Vol.53, 306-314. doi:https://doi.org/10.2337/diabetes.53.2.306

Effect of Moderate Exercise Training on Peripheral Glucose Effectiveness, Insulin Sensitivity, and Endogenous Glucose Production in Healthy Humans Estimated by a Two-Compartment-Labeled Minimal Model

Yuichiro Nishida; Kumpei Tokuyama; Shoichiro Nagasaka; Yasuki Higaki; Yoko Shirai; Akira Kiyonaga; Munehiro Shindo; Ikuyo Kusaka; Tomoatsu Nakamura; Shun Ishibashi; Hiroaki Tanaka

Abstracts

View articletitled, Effect of Moderate Exercise Training on Peripheral Glucose Effectiveness, Insulin Sensitivity, and Endogenous Glucose Production in Healthy Humans Estimated by a Two-Compartment-Labeled Minimal Model

Open the PDF for in another window

Topics: glucose , insulin , insulin sensitivity

Diabetes February 2004, Vol.53, 315-320. doi:https://doi.org/10.2337/diabetes.53.2.315

Signal Transduction

Sterol Regulatory Element-Binding Protein-1 Mediates the Effect of Insulin on Hexokinase II Gene Expression in Human Muscle Cells

Yvan Gosmain; Etienne Lefai; Stephan Ryser; Marina Roques; Hubert Vidal

Abstract

View articletitled, Sterol Regulatory Element-Binding Protein-1 Mediates the Effect of Insulin on Hexokinase II Gene Expression in Human Muscle Cells

Open the PDF for in another window

Topics: insulin , serious reportable event , skeletal myocytes , muscle cells , hexokinase

Diabetes February 2004, Vol.53, 321-329. doi:https://doi.org/10.2337/diabetes.53.2.321

Ca²⁺ and AMPK Both Mediate Stimulation of Glucose Transport by Muscle Contractions

David C. Wright; Kathleen A. Hucker; John O. Holloszy; Dong Ho Han

Abstract

View articletitled, Ca2+ and AMPK Both Mediate Stimulation of Glucose Transport by Muscle Contractions

Open the PDF for in another window

Topics: aica ribonucleotide , ampk , caffeine , glucose transport , muscle contraction

Diabetes February 2004, Vol.53, 330-335. doi:https://doi.org/10.2337/diabetes.53.2.330

Obesity Study

Prevention of Obesity and Insulin Resistance in Mice Lacking Plasminogen Activator Inhibitor 1

Li-Jun Ma; Su-Li Mao; Kevin L. Taylor; Talerngsak Kanjanabuch; YouFei Guan; YaHua Zhang; Nancy J. Brown; Larry L. Swift; Owen P. McGuinness; David H. Wasserman; Douglas E. Vaughan; Agnes B. Fogo

Abstract

View articletitled, Prevention of Obesity and Insulin Resistance in Mice Lacking Plasminogen Activator Inhibitor 1

Open the PDF for in another window

Topics: mice , plasminogen activator inhibitor 1 , diet , heart failure , obesity

Diabetes February 2004, Vol.53, 336-346. doi:https://doi.org/10.2337/diabetes.53.2.336

Leptin Impairs Insulin Signaling in Rat Adipocytes

Coralia Pérez; Carmen Fernández-Galaz; Teresa Fernández-Agulló; Carmen Arribas; Antonio Andrés; Manuel Ros; José M. Carrascosa

Abstracts

View articletitled, Leptin Impairs Insulin Signaling in Rat Adipocytes

Open the PDF for in another window

Topics: adipocytes , insulin , leptin , mitogen-activated protein kinases , phosphorylation

Diabetes February 2004, Vol.53, 347-353. doi:https://doi.org/10.2337/diabetes.53.2.347

Immunology and Transplantation

Proinsulin Expression by Hassall’s Corpuscles in the Mouse Thymus

Aziz Alami Chentoufi; Michael Palumbo; Constantin Polychronakos

Abstracts

View articletitled, Proinsulin Expression by Hassall’s Corpuscles in the Mouse Thymus

Open the PDF for in another window

Topics: mice , proinsulin , thymus gland , insulin , transient erythroblastopenia of childhood

Diabetes February 2004, Vol.53, 354-359. doi:https://doi.org/10.2337/diabetes.53.2.354

Exercise Induces Hypoglycemia in Rats With Islet Transplantation

Abdulkadir Omer; Valérie F. Duvivier-Kali; William Aschenbach; Vaja Tchipashvili; Laurie J. Goodyear; Gordon C. Weir

Abstract

View articletitled, Exercise Induces Hypoglycemia in Rats With Islet Transplantation

Open the PDF for in another window

Topics: blood glucose , c-peptide , glucose , greater sac of peritoneum , liver

Diabetes February 2004, Vol.53, 360-365. doi:https://doi.org/10.2337/diabetes.53.2.360

Gene Expression Profiles Define a Key Checkpoint for Type 1 Diabetes in NOD Mice

Sarah E. Eckenrode; Qingguo Ruan; Ping Yang; Weipeng Zheng; Richard A. McIndoe; Jin-Xiong She

Abstracts

View articletitled, Gene Expression Profiles Define a Key Checkpoint for Type 1 Diabetes in NOD Mice

Open the PDF for in another window

Topics: diabetes mellitus, type 1 , genes , mice , mice, inbred nod , polymerase chain reaction

Diabetes February 2004, Vol.53, 366-375. doi:https://doi.org/10.2337/diabetes.53.2.366

Mixed Hematopoietic Chimerism Allows Cure of Autoimmune Diabetes Through Allogeneic Tolerance and Reversal of Autoimmunity

Boris Nikolic; Yasuo Takeuchi; Igor Leykin; Yasuhiro Fudaba; R. Neal Smith; Megan Sykes

Abstracts

View articletitled, Mixed Hematopoietic Chimerism Allows Cure of Autoimmune Diabetes Through Allogeneic Tolerance and Reversal of Autoimmunity

Open the PDF for in another window

Topics: autoimmunity , chimera organism , chimerism , conditioning (psychology) , donors

Diabetes February 2004, Vol.53, 376-383. doi:https://doi.org/10.2337/diabetes.53.2.376

Stratification of Type 1 Diabetes Risk on the Basis of Islet Autoantibody Characteristics

Peter Achenbach; Katharina Warncke; Jürgen Reiter; Heike E. Naserke; Alistair J.K. Williams; Polly J. Bingley; Ezio Bonifacio; Anette-G. Ziegler

Abstract

View articletitled, Stratification of Type 1 Diabetes Risk on the Basis of Islet Autoantibody Characteristics

Open the PDF for in another window

Topics: autoantibodies , diabetes mellitus, type 1 , epitopes

Diabetes February 2004, Vol.53, 384-392. doi:https://doi.org/10.2337/diabetes.53.2.384

Islet Studies

Role for Plasma Membrane-Related Ca²⁺-ATPase-1 (ATP2C1) in Pancreatic β-Cell Ca²⁺ Homeostasis Revealed by RNA Silencing

Kathryn J. Mitchell; Takashi Tsuboi; Guy A. Rutter

Abstracts

View articletitled, Role for Plasma Membrane-Related Ca2+-ATPase-1 (ATP2C1) in Pancreatic β-Cell Ca2+ Homeostasis Revealed by RNA Silencing

Supplementary data

Open the PDF for in another window

Topics: adenosine triphosphatases , aequorin , cytosol , emergency service, hospital , glucose

Diabetes February 2004, Vol.53, 393-400. doi:https://doi.org/10.2337/diabetes.53.2.393

Regulation of ATP/ADP in Pancreatic Islets

Ian R. Sweet; Daniel L. Cook; Eric DeJulio; Angela R. Wallen; Gamal Khalil; James Callis; JoAnna Reems

Abstract

View articletitled, Regulation of ATP/ADP in Pancreatic Islets

Open the PDF for in another window

Topics: cytochrome c , glucose , glyburide , oxygen consumption , oxygen

Diabetes February 2004, Vol.53, 401-409. doi:https://doi.org/10.2337/diabetes.53.2.401

Pathophysiology

Reduction in Glucagon Receptor Expression by an Antisense Oligonucleotide Ameliorates Diabetic Syndrome in db/db Mice

Yin Liang; Melville C. Osborne; Brett P. Monia; Sanjay Bhanot; William A. Gaarde; Chantal Reed; Pengxiang She; Thomas L. Jetton; Keith T. Demarest

Abstract

View articletitled, Reduction in Glucagon Receptor Expression by an Antisense Oligonucleotide Ameliorates Diabetic Syndrome in db/db Mice

Open the PDF for in another window

Topics: glucagon , glucagon receptors , hepatocytes , mice , antisense oligonucleotides

Diabetes February 2004, Vol.53, 410-417. doi:https://doi.org/10.2337/diabetes.53.2.410

Effect of Recurrent Hypoglycemia on Spatial Cognition and Cognitive Metabolism in Normal and Diabetic Rats

Ewan C. McNay; Robert S. Sherwin

Abstract

View articletitled, Effect of Recurrent Hypoglycemia on Spatial Cognition and Cognitive Metabolism in Normal and Diabetic Rats

Open the PDF for in another window

Topics: glucose , hippocampus , hypoglycemia , plasma glucose , blood glucose normal

Diabetes February 2004, Vol.53, 418-425. doi:https://doi.org/10.2337/diabetes.53.2.418

Insulin Secretion in Type 1 Diabetes

Chynna Steele; William A. Hagopian; Stephen Gitelman; Umesh Masharani; Melissa Cavaghan; Kristina I. Rother; David Donaldson; David M. Harlan; Jeffrey Bluestone; Kevan C. Herold

Abstracts

View articletitled, Insulin Secretion in Type 1 Diabetes

Open the PDF for in another window

Topics: diabetes mellitus, type 1 , insulin , insulin secretion , c-peptide

Diabetes February 2004, Vol.53, 426-433. doi:https://doi.org/10.2337/diabetes.53.2.426

Electrocardiographic Repolarization Complexity and Abnormality Predict All-Cause and Cardiovascular Mortality in Diabetes: The Strong Heart Study

Peter M. Okin; Richard B. Devereux; Elisa T. Lee; James M. Galloway; Barbara V. Howard

Abstracts

View articletitled, Electrocardiographic Repolarization Complexity and Abnormality Predict All-Cause and Cardiovascular Mortality in Diabetes: The Strong Heart Study

Open the PDF for in another window

Topics: electrocardiogram , heart , prolonged qt interval , qt interval , qtc

Diabetes February 2004, Vol.53, 434-440. doi:https://doi.org/10.2337/diabetes.53.2.434

Decrease in Glucose-Stimulated Insulin Secretion With Aging Is Independent of Insulin Action

Radhika Muzumdar; Xiaohui Ma; Gil Atzmon; Patricia Vuguin; Xiaoman Yang; Nir Barzilai

Abstract

View articletitled, Decrease in Glucose-Stimulated Insulin Secretion With Aging Is Independent of Insulin Action

Open the PDF for in another window

Topics: glucose , hyperglycemic agents , insulin , insulin secretion , rats

Diabetes February 2004, Vol.53, 441-446. doi:https://doi.org/10.2337/diabetes.53.2.441

Insulin Sensitivity of Muscle Capillary Recruitment In Vivo

Lei Zhang; Michelle A. Vincent; Stephen M. Richards; Lucy H. Clerk; Stephen Rattigan; Michael G. Clark; Eugene J. Barrett

Abstract

View articletitled, Insulin Sensitivity of Muscle Capillary Recruitment In Vivo

Open the PDF for in another window

Topics: blood capillaries , glucose , infusion procedures , insulin , vascular flow

Diabetes February 2004, Vol.53, 447-453. doi:https://doi.org/10.2337/diabetes.53.2.447

Complication

Absence of Inducible Nitric Oxide Synthase Reduces Myocardial Damage During Ischemia Reperfusion in Streptozotocin-Induced Hyperglycemic Mice

Raffaele Marfella; Clara Di Filippo; Katherine Esposito; Francesco Nappo; Elena Piegari; Salvatore Cuzzocrea; Liberato Berrino; Francesco Rossi; Dario Giugliano; Michele D’Amico

Abstracts

View articletitled, Absence of Inducible Nitric Oxide Synthase Reduces Myocardial Damage During Ischemia Reperfusion in Streptozotocin-Induced Hyperglycemic Mice

Open the PDF for in another window

Topics: mice , nitric oxide synthase , reperfusion therapy , streptozocin , reperfusion injury

Diabetes February 2004, Vol.53, 454-462. doi:https://doi.org/10.2337/diabetes.53.2.454

Diabetes Increases Formation of Advanced Glycation End Products on Sarco(endo)plasmic Reticulum Ca²⁺-ATPase

Keshore R. Bidasee; Yinong Zhang; Chun Hong Shao; Mu Wang; Kaushik P. Patel; Ü. Deniz Dincer; Henry R. Besch, Jr.

Abstract

View articletitled, Diabetes Increases Formation of Advanced Glycation End Products on Sarco(endo)plasmic Reticulum Ca2+-ATPase

Open the PDF for in another window

Topics: heart , sarcoplasmic reticulum calcium-transporting atpase 2a , insulin , peptides

Diabetes February 2004, Vol.53, 463-473. doi:https://doi.org/10.2337/diabetes.53.2.463

Genetics

Increased Risk of Type 2 Diabetes in Alzheimer Disease

Juliette Janson; Thomas Laedtke; Joseph E. Parisi; Peter O’Brien; Ronald C. Petersen; Peter C. Butler

Abstracts

View articletitled, Increased Risk of Type 2 Diabetes in Alzheimer Disease

Open the PDF for in another window

Topics: alzheimer's disease , amyloid , diabetes mellitus, type 2 , brain

Diabetes February 2004, Vol.53, 474-481. doi:https://doi.org/10.2337/diabetes.53.2.474

Uncoupling Protein 2 Promoter Polymorphism −866G/A Affects Its Expression in β-Cells and Modulates Clinical Profiles of Japanese Type 2 Diabetic Patients

Miyoshi Sasahara; Masahiro Nishi; Hiromichi Kawashima; Kazuya Ueda; Setsuya Sakagashira; Hiroto Furuta; Eisaku Matsumoto; Tadashi Hanabusa; Hideyuki Sasaki; Kishio Nanjo

Abstract

View articletitled, Uncoupling Protein 2 Promoter Polymorphism −866G/A Affects Its Expression in β-Cells and Modulates Clinical Profiles of Japanese Type 2 Diabetic Patients

Open the PDF for in another window

Topics: alleles , genotype , glucose , hemoglobin a, glycosylated , insulin

Diabetes February 2004, Vol.53, 482-485. doi:https://doi.org/10.2337/diabetes.53.2.482

Examination of Candidate Chromosomal Regions for Type 2 Diabetes Reveals a Susceptibility Locus on Human Chromosome 8p23.1

Marcus G. Pezzolesi; Moonsuk Nam; Terumasa Nagase; Tomasz Klupa; Jonathon S. Dunn; Wojciech M. Mlynarski; Stephen S. Rich; James H. Warram; Andrzej S. Krolewski

Abstracts

View articletitled, Examination of Candidate Chromosomal Regions for Type 2 Diabetes Reveals a Susceptibility Locus on Human Chromosome 8p23.1

Supplementary data

Open the PDF for in another window

Topics: chromosomes , diabetes mellitus, type 2

Diabetes February 2004, Vol.53, 486-491. doi:https://doi.org/10.2337/diabetes.53.2.486

Linkage and Association Mapping of a Chromosome 1q21-q24 Type 2 Diabetes Susceptibility Locus in Northern European Caucasians

Swapan Kumar Das; Sandra J. Hasstedt; Zhengxian Zhang; Steven C. Elbein

Abstracts

View articletitled, Linkage and Association Mapping of a Chromosome 1q21-q24 Type 2 Diabetes Susceptibility Locus in Northern European Caucasians

Supplementary data

Open the PDF for in another window

Topics: diabetes mellitus, type 2 , genetic linkage analysis , haplotypes , chromosomes , lod score

Diabetes February 2004, Vol.53, 492-499. doi:https://doi.org/10.2337/diabetes.53.2.492

Brief Genetics Report

Messenger RNA Transcripts of the Hepatocyte Nuclear Factor-1α Gene Containing Premature Termination Codons Are Subject to Nonsense-Mediated Decay

Lorna W. Harries; Andrew T. Hattersley; Sian Ellard

Abstract

View articletitled, Messenger RNA Transcripts of the Hepatocyte Nuclear Factor-1α Gene Containing Premature Termination Codons Are Subject to Nonsense-Mediated Decay

Open the PDF for in another window

Topics: alleles , cell lines , codon, nonsense , genes , hepatocytes

Diabetes February 2004, Vol.53, 500-504. doi:https://doi.org/10.2337/diabetes.53.2.500

Haplotype Tag Single Nucleotide Polymorphism Analysis of the Human Orthologues of the Rat Type 1 Diabetes Genes Ian4 (Lyp/Iddm1) and Cblb

Felicity Payne; Deborah J. Smyth; Rebecca Pask; Bryan J. Barratt; Jason D. Cooper; Rebecca C.J. Twells; Neil M. Walker; Alex C. Lam; Luc J. Smink; Sarah Nutland; Helen E. Rance; John A. Todd

Abstracts

View articletitled, Haplotype Tag Single Nucleotide Polymorphism Analysis of the Human Orthologues of the Rat Type 1 Diabetes Genes Ian4 (Lyp/Iddm1) and Cblb

Open the PDF for in another window

Topics: diabetes mellitus, type 1 , genes , genotype determination , haplotypes , single nucleotide polymorphism

Diabetes February 2004, Vol.53, 505-509. doi:https://doi.org/10.2337/diabetes.53.2.505

Issues

Banting Lecture 2003

Perspectives in Diabetes

Metabolism

Signal Transduction

Obesity Study

Immunology and Transplantation

Islet Studies

Pathophysiology

Complication

Genetics

Brief Genetics Report

Email alerts

RSS Feeds

Journals

Books

Clinical Compendia

News

Other

About

Resources

This Feature Is Available To Subscribers Only