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Issues
1 March 2004
ISSN 0012-1797
EISSN 1939-327X
Perspectives in Diabetes
Transcriptional Control of Apolipoprotein A-I Gene Expression in Diabetes
Diabetes March 2004, Vol.53, 513-520. doi:https://doi.org/10.2337/diabetes.53.3.513
Metabolism
Systemic and Forearm Triglyceride Metabolism: Fate of Lipoprotein Lipase-Generated Glycerol and Free Fatty Acids
John M. Miles; Yongsoon S. Park; Dorota Walewicz; Crystal Russell-Lopez; Sheryl Windsor; William L. Isley; Simon W. Coppack; William S. Harris
Diabetes March 2004, Vol.53, 521-527. doi:https://doi.org/10.2337/diabetes.53.3.521
Muscle-Type Specific Intramyocellular and Hepatic Lipid Metabolism During Starvation in Wistar Rats
Claudia Neumann-Haefelin; Anja Beha; Johanna Kuhlmann; Ulrich Belz; Martin Gerl; Manfred Quint; Gabriele Biemer-Daub; Mark Broenstrup; Marion Stein; Elke Kleinschmidt; Hans-Ludwig Schaefer; Dieter Schmoll; Werner Kramer; Hans-Paul Juretschke; Andreas W. Herling
Diabetes March 2004, Vol.53, 528-534. doi:https://doi.org/10.2337/diabetes.53.3.528
Stimulation of Hepatocyte Glucose Metabolism by Novel Small Molecule Glucokinase Activators
Katy J. Brocklehurst; Victoria A. Payne; Rick A. Davies; Debra Carroll; Helen L. Vertigan; Heather J. Wightman; Susan Aiston; Ian D. Waddell; Brendan Leighton; Matthew P. Coghlan; Loranne Agius
Diabetes March 2004, Vol.53, 535-541. doi:https://doi.org/10.2337/diabetes.53.3.535
Reduced Lipid Oxidation in Skeletal Muscle From Type 2 Diabetic Subjects May Be of Genetic Origin: Evidence From Cultured Myotubes
Diabetes March 2004, Vol.53, 542-548. doi:https://doi.org/10.2337/diabetes.53.3.542
Signal Transduction
Physiological and Molecular Characteristics of Rat Hypothalamic Ventromedial Nucleus Glucosensing Neurons
Diabetes March 2004, Vol.53, 549-559. doi:https://doi.org/10.2337/diabetes.53.3.549
Insulin-Independent Induction of Sterol Regulatory Element-Binding Protein-1c Expression in the Livers of Streptozotocin-Treated Mice
Takashi Matsuzaka; Hitoshi Shimano; Naoya Yahagi; Michiyo Amemiya-Kudo; Hiroaki Okazaki; Yoshiaki Tamura; Yoko Iizuka; Ken Ohashi; Sachiko Tomita; Motohiro Sekiya; Alyssa Hasty; Yoshimi Nakagawa; Hirohito Sone; Hideo Toyoshima; Shun Ishibashi; Jun-ichi Osuga; Nobuhiro Yamada
Diabetes March 2004, Vol.53, 560-569. doi:https://doi.org/10.2337/diabetes.53.3.560
Obesity Study
Mice with Targeted Disruption of the Dio2 Gene Have Cold-Induced Overexpression of the Uncoupling Protein 1 Gene but Fail to Increase Brown Adipose Tissue Lipogenesis and Adaptive Thermogenesis
Marcelo A. Christoffolete; Camila C.G. Linardi; Lucia de Jesus; Katia Naomi Ebina; Suzy D. Carvalho; Miriam O. Ribeiro; Rogerio Rabelo; Cyntia Curcio; Luciane Martins; Edna T. Kimura; Antonio C. Bianco
Diabetes March 2004, Vol.53, 577-584. doi:https://doi.org/10.2337/diabetes.53.3.577
Immunology
Virally Induced Inflammation Triggers Fratricide of Fas-Ligand–Expressing β-Cells
Urs Christen; Rima Darwiche; Helen E. Thomas; Tom Wolfe; Evelyn Rodrigo; Alexander Chervonsky; Richard A. Flavell; Matthias G. von Herrath
Diabetes March 2004, Vol.53, 591-596. doi:https://doi.org/10.2337/diabetes.53.3.591
Islet Study
Expression of Voltage-Gated Potassium Channels in Human and Rhesus Pancreatic Islets
Lizhen Yan; David J. Figueroa; Christopher P. Austin; Yuan Liu; Randal M. Bugianesi; Robert S. Slaughter; Gregory J. Kaczorowski; Martin G. Kohler
Diabetes March 2004, Vol.53, 597-607. doi:https://doi.org/10.2337/diabetes.53.3.597
Activin A and Betacellulin: Effect on Regeneration of Pancreatic β-Cells in Neonatal Streptozotocin-Treated Rats
Diabetes March 2004, Vol.53, 608-615. doi:https://doi.org/10.2337/diabetes.53.3.608
No Evidence for Significant Transdifferentiation of Bone Marrow Into Pancreatic β-Cells In Vivo
Diabetes March 2004, Vol.53, 616-623. doi:https://doi.org/10.2337/diabetes.53.3.616
Structural and Functional Abnormalities in the Islets Isolated From Type 2 Diabetic Subjects
Shaoping Deng; Marko Vatamaniuk; Xiaolun Huang; Nicolai Doliba; Moh-Moh Lian; Adam Frank; Ergun Velidedeoglu; Niraj M. Desai; Brigitte Koeberlein; Bryan Wolf; Clyde F. Barker; Ali Naji; Franz M. Matschinsky; James F. Markmann
Diabetes March 2004, Vol.53, 624-632. doi:https://doi.org/10.2337/diabetes.53.3.624
Pathophysiology
Consequences on β-Cell Function and Reserve After Long-Term Pancreas Transplantation
Diabetes March 2004, Vol.53, 633-644. doi:https://doi.org/10.2337/diabetes.53.3.633
Ketosis-Prone Type 2 Diabetes in Patients of Sub-Saharan African Origin: Clinical Pathophysiology and Natural History of β-Cell Dysfunction and Insulin Resistance
Franck Mauvais-Jarvis; Eugène Sobngwi; Raphaël Porcher; Jean-Pierre Riveline; Jean-Philippe Kevorkian; Christian Vaisse; Guillaume Charpentier; Pierre-Jean Guillausseau; Patrick Vexiau; Jean-François Gautier
Diabetes March 2004, Vol.53, 645-653. doi:https://doi.org/10.2337/diabetes.53.3.645
Secretion, Degradation, and Elimination of Glucagon-Like Peptide 1 and Gastric Inhibitory Polypeptide in Patients with Chronic Renal Insufficiency and Healthy Control Subjects
Juris J. Meier; Michael A. Nauck; Daniel Kranz; Jens J. Holst; Carolyn F. Deacon; Dirk Gaeckler; Wolfgang E. Schmidt; Baptist Gallwitz
Diabetes March 2004, Vol.53, 654-662. doi:https://doi.org/10.2337/diabetes.53.3.654
Parasympathetic Blockade Attenuates Augmented Pancreatic Polypeptide But Not Insulin Secretion in Pima Indians
Barbora Vozarova de Courten; Christian Weyer; Norbert Stefan; Mark Horton; Angelo DelParigi; Peter Havel; Clifton Bogardus; P. Antonio Tataranni
Diabetes March 2004, Vol.53, 663-671. doi:https://doi.org/10.2337/diabetes.53.3.663
In Vitro Transcriptional Induction of the Human Apolipoprotein A-II Gene by Glucose
Dominique Sauvaget; Valérie Chauffeton; Sonia Dugué-Pujol; Athina-Despina Kalopissis; Isabelle Guillet-Deniau; Fabienne Foufelle; Jean Chambaz; Armelle Leturque; Philippe Cardot; Agnès Ribeiro
Diabetes March 2004, Vol.53, 672-678. doi:https://doi.org/10.2337/diabetes.53.3.672
The Effects of Dehydroepiandrosterone Sulfate on Counterregulatory Responses During Repeated Hypoglycemia in Conscious Normal Rats
Diabetes March 2004, Vol.53, 679-686. doi:https://doi.org/10.2337/diabetes.53.3.679
Magnetic Resonance Imaging of the Brain in Diabetes: The Cardiovascular Determinants of Dementia (CASCADE) Study
Reinhold Schmidt; Lenore J. Launer; Lars-Göran Nilsson; Andrzej Pajak; Susanna Sans; Klaus Berger; Monique M. Breteler; Maria de Ridder; Carole Dufouil; Rebecca Fuhrer; Simona Giampaoli; Albert Hofman; for the CASCADE Consortium
Diabetes March 2004, Vol.53, 687-692. doi:https://doi.org/10.2337/diabetes.53.3.687
Inflammatory Markers and Risk of Developing Type 2 Diabetes in Women
Diabetes March 2004, Vol.53, 693-700. doi:https://doi.org/10.2337/diabetes.53.3.693
Effect of Postprandial Hypertriglyceridemia and Hyperglycemia on Circulating Adhesion Molecules and Oxidative Stress Generation and the Possible Role of Simvastatin Treatment
Antoniom Ceriello; Lisa Quagliaro; Ludovica Piconi; Roberta Assaloni; Roberto Da Ros; Amabile Maier; Katherine Esposito; Dario Giugliano
Diabetes March 2004, Vol.53, 701-710. doi:https://doi.org/10.2337/diabetes.53.3.701
Complication
Role of Poly(ADP-Ribose) Polymerase Activation in Diabetic Neuropathy
Irina G. Obrosova; Fei Li; Omorodola I. Abatan; Mark A. Forsell; Katalin Komjáti; Pal Pacher; Csaba Szabó; Martin J. Stevens
Diabetes March 2004, Vol.53, 711-720. doi:https://doi.org/10.2337/diabetes.53.3.711
Uncoupling Proteins Prevent Glucose-Induced Neuronal Oxidative Stress and Programmed Cell Death
Diabetes March 2004, Vol.53, 726-734. doi:https://doi.org/10.2337/diabetes.53.3.726
Initial Characterization of a Rat Model of Diabetic Nephropathy
Marcelo A. Nobrega; Stewart Fleming; Richard J. Roman; Masahide Shiozawa; Nancy Schlick; Jozef Lazar; Howard J. Jacob
Diabetes March 2004, Vol.53, 735-742. doi:https://doi.org/10.2337/diabetes.53.3.735
Divergent Pathways of Gene Expression Are Activated by the RAGE Ligands S100b and AGE-BSA
Diabetes March 2004, Vol.53, 743-751. doi:https://doi.org/10.2337/diabetes.53.3.743
Hyperglycemia-Induced Defects in Angiogenesis in the Chicken Chorioallantoic Membrane Model
Diabetes March 2004, Vol.53, 752-761. doi:https://doi.org/10.2337/diabetes.53.3.752
Electrically Stimulated Axon Reflexes Are Diminished in Diabetic Small Fiber Neuropathies
Diabetes March 2004, Vol.53, 769-774. doi:https://doi.org/10.2337/diabetes.53.3.769
Potential Contributory Role of H-Ras, a Small G-Protein, in the Development of Retinopathy in Diabetic Rats
Diabetes March 2004, Vol.53, 775-783. doi:https://doi.org/10.2337/diabetes.53.3.775
Molecular Profiling of Diabetic Mouse Kidney Reveals Novel Genes Linked to Glomerular Disease
Katalin Susztak; Erwin Böttinger; Akiva Novetsky; Dan Liang; Yanqing Zhu; Emilio Ciccone; Dona Wu; Stephen Dunn; Peter McCue; Kumar Sharma
Diabetes March 2004, Vol.53, 784-794. doi:https://doi.org/10.2337/diabetes.53.3.784
Molecular Mechanisms of High Glucose-Induced Cyclooxygenase-2 Expression in Monocytes
Diabetes March 2004, Vol.53, 795-802. doi:https://doi.org/10.2337/diabetes.53.3.795
Genetics
A Genome-Wide Scan for Childhood Obesity–Associated Traits in French Families Shows Significant Linkage on Chromosome 6q22.31-q23.2
David Meyre; Cécile Lecoeur; Jérôme Delplanque; Stephan Francke; Vincent Vatin; Emmanuelle Durand; Jacques Weill; Christian Dina; Philippe Froguel
Diabetes March 2004, Vol.53, 803-811. doi:https://doi.org/10.2337/diabetes.53.3.803
An Obesity-Related Locus in Chromosome Region 12q23-24
Diabetes March 2004, Vol.53, 812-820. doi:https://doi.org/10.2337/diabetes.53.3.812
A Large Set of Finnish Affected Sibling Pair Families With Type 2 Diabetes Suggests Susceptibility Loci on Chromosomes 6, 11, and 14
Kaisa Silander; Laura J. Scott; Timo T. Valle; Karen L. Mohlke; Heather M. Stringham; Kerry R. Wiles; William L. Duren; Kimberly F. Doheny; Elizabeth W. Pugh; Peter Chines; Narisu Narisu; Peggy P. White; Tasha E. Fingerlin; Anne U. Jackson; Chun Li; Soumitra Ghosh; Victoria L. Magnuson; Kimberly Colby; Michael R. Erdos; Jason E. Hill; Pablo Hollstein; Kathleen M. Humphreys; Roshni A. Kasad; Jessica Lambert; Konstantinos N. Lazaridis; George Lin; Anabelle Morales-Mena; Kristin Patzkowski; Carrie Pfahl; Rachel Porter; David Rha; Leonid Segal; Yong D. Suh; Jason Tovar; Arun Unni; Christian Welch; Julie A. Douglas; Michael P. Epstein; Elizabeth R. Hauser; William Hagopian; Thomas A. Buchanan; Richard M. Watanabe; Richard N. Bergman; Jaakko Tuomilehto; Francis S. Collins; Michael Boehnke
Diabetes March 2004, Vol.53, 821-829. doi:https://doi.org/10.2337/diabetes.53.3.821
A Genome-Wide Scan for Type 2 Diabetes in African-American Families Reveals Evidence for a Locus on Chromosome 6q
Michèle M. Sale; Barry I. Freedman; Carl D. Langefeld; Adrienne H. Williams; Pamela J. Hicks; Carla J. Colicigno; Stephanie R. Beck; W. Mark Brown; Stephen S. Rich; Donald W. Bowden
Diabetes March 2004, Vol.53, 830-837. doi:https://doi.org/10.2337/diabetes.53.3.830
Brief Genetics Report
A Genome-Wide Search for Type 2 Diabetes Susceptibility Genes in West Africans : The Africa America Diabetes Mellitus (AADM) Study
Charles N. Rotimi; Guanjie Chen; Adebowale A. Adeyemo; Paulette Furbert-Harris; Debra Guass; Jie Zhou; Kate Berg; Olufemi Adegoke; Albert Amoah; Samuel Owusu; Joseph Acheampong; Kofi Agyenim-Boateng; Benjamin A. Eghan, Jr.; Johnnie Oli; Godfrey Okafor; Ester Ofoegbu; Babatunde Osotimehin; Fayeofori Abbiyesuku; Thomas Johnson; Theresa Rufus; Olufemi Fasanmade; Rick Kittles; Harold Daniel; Yuanxiu Chen; Georgia Dunston; Francis S. Collins
Diabetes March 2004, Vol.53, 838-841. doi:https://doi.org/10.2337/diabetes.53.3.838
Genetic Variants in Human Sterol Regulatory Element Binding Protein-1c in Syndromes of Severe Insulin Resistance and Type 2 Diabetes
Matthias Laudes; Inês Barroso; Jian’an Luan; Maria A. Soos; Giles Yeo; Aline Meirhaeghe; Lisa Logie; Antonio Vidal-Puig; Alan J. Schafer; Nick J. Wareham; Stephen O’Rahilly
Diabetes March 2004, Vol.53, 842-846. doi:https://doi.org/10.2337/diabetes.53.3.842
Genetic Polymorphisms in Peroxisome Proliferator-Activated Receptor δ Associated With Obesity
Hyoung Doo Shin; Byung Lae Park; Lyoung Hyo Kim; Hye Seung Jung; Young Min Cho; Min Kyong Moon; Young Joo Park; Hong Kyu Lee; Kyong Soo Park
Diabetes March 2004, Vol.53, 847-851. doi:https://doi.org/10.2337/diabetes.53.3.847
Association of Human Endogenous Retrovirus K-18 Polymorphisms With Type 1 Diabetes
Diabetes March 2004, Vol.53, 852-854. doi:https://doi.org/10.2337/diabetes.53.3.852
Evidence From a Large U.K. Family Collection That Genes Influencing Age of Onset of Type 2 Diabetes Map to Chromosome 12p and to the MODY3/NIDDM2 Locus on 12q24
Steven Wiltshire; Timothy M. Frayling; Christopher J. Groves; Jonathan C. Levy; Graham A. Hitman; Mike Sampson; Mark Walker; Stephan Menzel; Andrew T. Hattersley; Lon R. Cardon; Mark I. McCarthy
Diabetes March 2004, Vol.53, 855-860. doi:https://doi.org/10.2337/diabetes.53.3.855
Association of the VEGF Gene With Proliferative Diabetic Retinopathy But Not Proteinuria in Diabetes
Diabetes March 2004, Vol.53, 861-864. doi:https://doi.org/10.2337/diabetes.53.3.861
Scrutiny of the Glutamine-Fructose-6-Phosphate Transaminase 1 (GFPT1) Locus Reveals Conserved Haplotype Block Structure not Associated With Diabetic Nephropathy
Daniel P.K. Ng; William H. Walker; Kee-Seng Chia; Serena Choo; James H. Warram; Andrzej S. Krolewski
Diabetes March 2004, Vol.53, 865-869. doi:https://doi.org/10.2337/diabetes.53.3.865
Analysis of the Type 2 Diabetes-Associated Single Nucleotide Polymorphisms in the Genes IRS1, KCNJ11, and PPARG2 in Type 1 Diabetes
Christina Eftychi; Joanna M.M. Howson; Bryan J. Barratt; Adrian Vella; Felicity Payne; Deborah J. Smyth; Rebecca C.J. Twells; Neil M. Walker; Helen E. Rance; Eva Tuomilehto-Wolf; Jaakko Tuomilehto; Dag E. Undlien; Kjersti S. Rønningen; Cristian Guja; Constantin Ionescu-Tı̂irgovişte; David A. Savage; John A. Todd
Diabetes March 2004, Vol.53, 870-873. doi:https://doi.org/10.2337/diabetes.53.3.870
