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Issues
1 April 2004
ISSN 0012-1797
EISSN 1939-327X
Metabolism
Inhalation of Insulin in Dogs: Assessment of Insulin Levels and Comparison to Subcutaneous Injection
Alan D. Cherrington; Doss W. Neal; Dale S. Edgerton; Dana Glass; Larry Bowen; Charles H. Hobbs; Chet Leach; Ralf Rosskamp; Thomas R. Strack
Topics:
insulin
,
subcutaneous injections
Diabetes April 2004, Vol.53, 877-881. doi:https://doi.org/10.2337/diabetes.53.4.877
Signal Transduction
Modulation of Resistin Expression by Retinoic Acid and Vitamin A Status
Topics:
mice
,
resistin
,
tretinoin
,
vitamin a
,
rna, messenger
Diabetes April 2004, Vol.53, 882-889. doi:https://doi.org/10.2337/diabetes.53.4.882
Glucose Regulates the Expression of the Farnesoid X Receptor in Liver
Daniel Duran-Sandoval; Gisèle Mautino; Geneviève Martin; Fréderic Percevault; Olivier Barbier; Jean-Charles Fruchart; Folkert Kuipers; Bart Staels
Topics:
glucose
,
hepatocytes
,
rna, messenger
,
insulin
,
liver
Diabetes April 2004, Vol.53, 890-898. doi:https://doi.org/10.2337/diabetes.53.4.890
Protein Kinase B-α Inhibits Human Pyruvate Dehydrogenase Kinase-4 Gene Induction by Dexamethasone Through Inactivation of FOXO Transcription Factors
Topics:
dexamethasone
,
glucocorticoids
,
insulin
,
binding (molecular function)
,
phosphotransferases
Diabetes April 2004, Vol.53, 899-910. doi:https://doi.org/10.2337/diabetes.53.4.899
Ciliary Neurotrophic Factor and Leptin Induce Distinct Patterns of Immediate Early Gene Expression in the Brain
Joseph F. Kelly; Carol F. Elias; Charlotte E. Lee; Rexford S. Ahima; Randy J. Seeley; Christian Bjørbæk; Takakazu Oka; Clifford B. Saper; Jeffrey S. Flier; Joel K. Elmquist
Topics:
ciliary neurotrophic factor
,
leptin
,
rna, messenger
,
brain
,
suppressor of cytokine signaling 3 protein
Diabetes April 2004, Vol.53, 911-920. doi:https://doi.org/10.2337/diabetes.53.4.911
Prolonged Incubation in PUGNAc Results in Increased Protein O-Linked Glycosylation and Insulin Resistance in Rat Skeletal Muscle
Topics:
insulin
,
insulin resistance
,
proto-oncogene proteins c-akt
,
skeletal muscles
,
phosphorylation
Diabetes April 2004, Vol.53, 921-930. doi:https://doi.org/10.2337/diabetes.53.4.921
Obesity Study
Novel Adipose Tissue–Mediated Resistance to Diet-Induced Visceral Obesity in 11β-Hydroxysteroid Dehydrogenase Type 1–Deficient Mice
Nicholas M. Morton; Janice M. Paterson; Hiroaki Masuzaki; Megan C. Holmes; Bart Staels; Catherine Fievet; Brian R. Walker; Jeffrey S. Flier; John J. Mullins; Jonathan R. Seckl
Topics:
adipose tissue
,
diet
,
insulin
,
mice
,
mice, inbred c57bl
Diabetes April 2004, Vol.53, 931-938. doi:https://doi.org/10.2337/diabetes.53.4.931
Restoration of Adiponectin Pulsatility in Severely Obese Subjects After Weight Loss
Menotti Calvani; Antonio Scarfone; Luigi Granato; Elena Valera Mora; Giuseppe Nanni; Marco Castagneto; Aldo V. Greco; Melania Manco; Geltrude Mingrone
Topics:
adiponectin
,
insulin
,
obesity, morbid
,
weight reduction
,
obesity
Diabetes April 2004, Vol.53, 939-947. doi:https://doi.org/10.2337/diabetes.53.4.939
Immunology and Transplantation
Evidence of Functional Impairment of Syngeneically Transplanted Mouse Pancreatic Islets Retrieved from the Liver
Topics:
endocrine pancreas
,
glucose
,
insulin
,
liver
,
oxidation
Diabetes April 2004, Vol.53, 948-954. doi:https://doi.org/10.2337/diabetes.53.4.948
Assessment of the Severity of Hypoglycemia and Glycemic Lability in Type 1 Diabetic Subjects Undergoing Islet Transplantation
Edmond A. Ryan; Tami Shandro; Kristy Green; Breay W. Paty; Peter A. Senior; David Bigam; A.M. James Shapiro; Marie-Christine Vantyghem
Topics:
glucose
,
hypoglycemia
,
islets of langerhans transplantation
,
transplantation
,
hypoglycemic agents
Diabetes April 2004, Vol.53, 955-962. doi:https://doi.org/10.2337/diabetes.53.4.955
Elevated Vascular Endothelial Growth Factor Production in Islets Improves Islet Graft Vascularization
Nan Zhang; Anja Richter; Jenny Suriawinata; Sonal Harbaran; Jennifer Altomonte; Lin Cong; Haojiang Zhang; Keying Song; Marcia Meseck; Jonathan Bromberg; Hengjiang Dong
Topics:
tissue transplants
,
vascular endothelial growth factor a
,
spatial vectors
,
mice
,
endocrine pancreas
Diabetes April 2004, Vol.53, 963-970. doi:https://doi.org/10.2337/diabetes.53.4.963
Differential Recognition and Activation Thresholds in Human Autoreactive GAD-Specific T-Cells
Roberto Mallone; Sharon A. Kochik; Elsa M. Laughlin; Vivian H. Gersuk; Helena Reijonen; William W. Kwok; Gerald T. Nepom
Topics:
generalized anxiety disorder
,
t-lymphocytes
,
transmyocardial revascularization by laser technique
,
cytokine
,
clone cells
Diabetes April 2004, Vol.53, 971-977. doi:https://doi.org/10.2337/diabetes.53.4.971
T-Cell Receptor Transgenic Response to an Endogenous Polymorphic Autoantigen Determines Susceptibility to Diabetes
Mary E. Pauza; Cathleen M. Dobbs; Jing He; Tricia Patterson; Steven Wagner; Brian S. Anobile; Brenda J. Bradley; David Lo; Kathryn Haskins
Topics:
animals, transgenic
,
antigens
,
autoantigens
,
mice
,
mice, inbred nod
Diabetes April 2004, Vol.53, 978-988. doi:https://doi.org/10.2337/diabetes.53.4.978
Islet Study
Improved Islet Morphology after Blockade of the Renin- Angiotensin System in the ZDF Rat
Christos Tikellis; Peter J. Wookey; Riccardo Candido; Sof Andrikopoulos; Merlin C. Thomas; Mark E. Cooper
Topics:
angiotensin ii
,
apoptosis
,
endocrine pancreas
,
fibrosis
,
immunohistochemistry
Diabetes April 2004, Vol.53, 989-997. doi:https://doi.org/10.2337/diabetes.53.4.989
Metabotropic Glutamate Receptor Type 4 Is Involved in Autoinhibitory Cascade for Glucagon Secretion by α-Cells of Islet of Langerhans
Shunsuke Uehara; Akiko Muroyama; Noriko Echigo; Riyo Morimoto; Masato Otsuka; Shouki Yatsushiro; Yoshinori Moriyama
Topics:
antibodies
,
cyclic amp
,
endocrine pancreas
,
glucagon secretion
,
glutamate
Diabetes April 2004, Vol.53, 998-1006. doi:https://doi.org/10.2337/diabetes.53.4.998
A Role for the Malonyl-CoA/Long-Chain Acyl-CoA Pathway of Lipid Signaling in the Regulation of Insulin Secretion in Response to Both Fuel and Nonfuel Stimuli
Raphaël Roduit; Christopher Nolan; Cristina Alarcon; Patrick Moore; Annie Barbeau; Viviane Delghingaro-Augusto; Ewa Przybykowski; Johane Morin; Frédéric Massé; Bernard Massie; Neil Ruderman; Christopher Rhodes; Vincent Poitout; Marc Prentki
Topics:
fatty acids
,
glucose
,
insulin secretion
,
lipids
,
malonyl coenzyme a
Diabetes April 2004, Vol.53, 1007-1019. doi:https://doi.org/10.2337/diabetes.53.4.1007
Interaction of 6-Phosphofructo-2-Kinase/Fructose-2,6-Bisphosphatase (PFK-2/FBPase-2) With Glucokinase Activates Glucose Phosphorylation and Glucose Metabolism in Insulin-Producing Cells
Topics:
enzyme activity
,
enzymes
,
glucose
,
glucose metabolism
,
insulin
Diabetes April 2004, Vol.53, 1020-1029. doi:https://doi.org/10.2337/diabetes.53.4.1020
Regulated Expression of pdx-1 Promotes In Vitro Differentiation of Insulin-Producing Cells From Embryonic Stem Cells
Topics:
embryonic stem cells
,
insulin
,
pancreas
Diabetes April 2004, Vol.53, 1030-1037. doi:https://doi.org/10.2337/diabetes.53.4.1030
Glucose Inhibition of Glucagon Secretion From Rat α-Cells Is Mediated by GABA Released From Neighboring β-Cells
Anna Wendt; Bryndis Birnir; Karsten Buschard; Jesper Gromada; Albert Salehi; Sabine Sewing; Patrik Rorsman; Matthias Braun
Topics:
gaba-a receptor
,
gamma-aminobutyric acid
,
glucose
,
antagonists
,
endocrine pancreas
Diabetes April 2004, Vol.53, 1038-1045. doi:https://doi.org/10.2337/diabetes.53.4.1038
Pathophysiology
Diabetic Patients Without Vascular Complications Display Enhanced Basal Platelet Activation and Decreased Antioxidant Status
Topics:
antioxidants
,
arachidonic acid
,
blood platelets
,
glutathione peroxidase
,
vascular complications
Diabetes April 2004, Vol.53, 1046-1051. doi:https://doi.org/10.2337/diabetes.53.4.1046
Thiazolidinediones, Like Metformin, Inhibit Respiratory Complex I: A Common Mechanism Contributing to Their Antidiabetic Actions?
Barbara Brunmair; Katrin Staniek; Florian Gras; Nicole Scharf; Aleksandra Althaym; Renate Clara; Michael Roden; Erich Gnaiger; Hans Nohl; Werner Waldhäusl; Clemens Fürnsinn
Topics:
antidiabetics
,
metformin
,
mitochondria
,
thiazolidinedione
,
rotenone
Diabetes April 2004, Vol.53, 1052-1059. doi:https://doi.org/10.2337/diabetes.53.4.1052
Differential Effects of Interleukin-6 and -10 on Skeletal Muscle and Liver Insulin Action In Vivo
Hyo-Jeong Kim; Takamasa Higashimori; So-Young Park; Hyejeong Choi; Jianying Dong; Yoon-Jung Kim; Hye-Lim Noh; You-Ree Cho; Gary Cline; Young-Bum Kim; Jason K. Kim
Topics:
insulin
,
insulin resistance
,
interleukin-10
,
interleukin-6
,
skeletal muscles
Diabetes April 2004, Vol.53, 1060-1067. doi:https://doi.org/10.2337/diabetes.53.4.1060
The Metabolic Syndrome, Circulating Oxidized LDL, and Risk of Myocardial Infarction in Well-Functioning Elderly People in the Health, Aging, and Body Composition Cohort
Paul Holvoet; Stephen B. Kritchevsky; Russell P. Tracy; Ann Mertens; Susan M. Rubin; Javed Butler; Bret Goodpaster; Tamara B. Harris
Topics:
low-density lipoproteins
,
metabolic syndrome x
,
myocardial infarction
,
older adult
,
insulin
Diabetes April 2004, Vol.53, 1068-1073. doi:https://doi.org/10.2337/diabetes.53.4.1068
Hexosamine Pathway Is Responsible for Inhibition by Diabetes of Phenylephrine-Induced Inotropy
Topics:
agonists
,
azaserine
,
glucosamine
,
heart
,
hexosamines
Diabetes April 2004, Vol.53, 1074-1081. doi:https://doi.org/10.2337/diabetes.53.4.1074
Oxidative Stress Impairs Skeletal Muscle Repair in Diabetic Rats
Manuela Aragno; Raffaella Mastrocola; Maria Graziella Catalano; Enrico Brignardello; Oliviero Danni; Giuseppe Boccuzzi
Topics:
dehydroepiandrosterone
,
dna
,
gastrocnemius muscle
,
oxidative stress
,
rats
Diabetes April 2004, Vol.53, 1082-1088. doi:https://doi.org/10.2337/diabetes.53.4.1082
Improved β-Cell Survival and Reduced Insulitis in a Type 1 Diabetic Rat Model After Treatment With a β-Cell–Selective KATP Channel Opener
Kresten Skak; Carsten F. Gotfredsen; Dorthe Lundsgaard; John Bondo Hansen; Jeppe Sturis; Helle Markholst
Topics:
insulin
,
rats
,
diazoxide
,
hyperglycemia
,
hemoglobin a, glycosylated
Diabetes April 2004, Vol.53, 1089-1095. doi:https://doi.org/10.2337/diabetes.53.4.1089
Complication
Prophylactic Gene Therapy With Human Tissue Kallikrein Ameliorates Limb Ischemia Recovery in Type 1 Diabetic Mice
Topics:
diabetes mellitus, type 1
,
endothelial cells
,
gene therapy
,
ischemia
,
mice
Diabetes April 2004, Vol.53, 1096-1103. doi:https://doi.org/10.2337/diabetes.53.4.1096
Angiopoietin-2 Causes Pericyte Dropout in the Normal Retina: Evidence for Involvement in Diabetic Retinopathy
Hans-Peter Hammes; Jihong Lin; Patrick Wagner; Yuxi Feng; Franziska vom Hagen; Thomas Krzizok; Oliver Renner; Georg Breier; Michael Brownlee; Urban Deutsch
Topics:
angiopoietins
,
blood capillaries
,
diabetic retinopathy
,
mice
,
mice, knockin
Diabetes April 2004, Vol.53, 1104-1110. doi:https://doi.org/10.2337/diabetes.53.4.1104
Transforming Growth Factor-β1 Production Is Correlated With Genetically Determined ACE Expression in Congenic Rats: A Possible Link Between ACE Genotype and Diabetic Nephropathy
Maria E. Pueyo; Mireille Challah; Dominique Gauguier; Liliane Louedec; Monique Philippe; Roger Gaertner; Michel Marre; Jean-Baptiste Michel; Marie-Paule Jacob
Topics:
genotype
,
rats
,
rna, messenger
,
diabetic nephropathy
,
lung
Diabetes April 2004, Vol.53, 1111-1118. doi:https://doi.org/10.2337/diabetes.53.4.1111
Regression of Advanced Diabetic Nephropathy by Hepatocyte Growth Factor Gene Therapy in Rats
Josep M. Cruzado; Núria Lloberas; Joan Torras; Marta Riera; Cristina Fillat; Immaculada Herrero-Fresneda; Josep M. Aran; Gabriela Alperovich; August Vidal; Josep M. Grinyó
Topics:
diabetic nephropathy
,
gene therapy
,
kidney
,
rats
,
connective tissue growth factor
Diabetes April 2004, Vol.53, 1119-1127. doi:https://doi.org/10.2337/diabetes.53.4.1119
Genetics
Maternal-Fetal Interactions and Birth Order Influence Insulin Variable Number of Tandem Repeats Allele Class Associations with Head Size at Birth and Childhood Weight Gain
Ken K. Ong; Clive J. Petry; Bryan J. Barratt; Susan Ring; Heather J. Cordell; Diane L. Wingate; the Avon Longitudinal Study of Pregnancy and Childhood Study Team; Marcus E. Pembrey; John A. Todd; David B. Dunger
Topics:
alleles
,
alspac study
,
child
,
fetus
,
genotype
Diabetes April 2004, Vol.53, 1128-1133. doi:https://doi.org/10.2337/diabetes.53.4.1128
A Common Polymorphism in the Upstream Promoter Region of the Hepatocyte Nuclear Factor-4α Gene on Chromosome 20q Is Associated With Type 2 Diabetes and Appears to Contribute to the Evidence for Linkage in an Ashkenazi Jewish Population
Latisha D. Love-Gregory; Jonathon Wasson; Jiyan Ma; Carol H. Jin; Benjamin Glaser; Brian K. Suarez; M. Alan Permutt
Topics:
chromosomes
,
diabetes mellitus, type 2
,
genes
,
heart sound p2
,
hepatocytes
Diabetes April 2004, Vol.53, 1134-1140. doi:https://doi.org/10.2337/diabetes.53.4.1134
Genetic Variation Near the Hepatocyte Nuclear Factor-4α Gene Predicts Susceptibility to Type 2 Diabetes
Kaisa Silander; Karen L. Mohlke; Laura J. Scott; Erin C. Peck; Pablo Hollstein; Andrew D. Skol; Anne U. Jackson; Panagiotis Deloukas; Sarah Hunt; George Stavrides; Peter S. Chines; Michael R. Erdos; Narisu Narisu; Karen N. Conneely; Chun Li; Tasha E. Fingerlin; Sharanjeet K. Dhanjal; Timo T. Valle; Richard N. Bergman; Jaakko Tuomilehto; Richard M. Watanabe; Michael Boehnke; Francis S. Collins
Topics:
diabetes mellitus, type 2
,
dna
,
genotype determination
,
heart sound p2
,
hepatocytes
Diabetes April 2004, Vol.53, 1141-1149. doi:https://doi.org/10.2337/diabetes.53.4.1141
Brief Genetics Report
Adiponectin Gene Polymorphisms and Adiponectin Levels Are Independently Associated With the Development of Hyperglycemia During a 3-Year Period: The Epidemiologic Data on the Insulin Resistance Syndrome Prospective Study
Frédéric Fumeron; Roberte Aubert; Afshan Siddiq; Dina Betoulle; Frank Péan; Samy Hadjadj; Jean Tichet; Elsie Wilpart; Marie-Claude Chesnier; Beverley Balkau; Philippe Froguel; Michel Marre; for the Epidemiologic Data on the Insulin Resistance Syndrome (DESIR) Study Group
Topics:
adiponectin
,
desir cohort
,
diabetes mellitus, type 2
,
hyperglycemia
,
impaired fasting glucose
Diabetes April 2004, Vol.53, 1150-1157. doi:https://doi.org/10.2337/diabetes.53.4.1150
Lack of Association of the Ala45Thr Polymorphism and Other Common Variants of the NeuroD Gene With Type 1 Diabetes
Adrian Vella; Joanna M.M. Howson; Bryan J. Barratt; Rebecca C.J. Twells; Helen E. Rance; Sarah Nutland; Eva Tuomilehto-Wolf; Jaakko Tuomilehto; Dag E. Undlien; Kjersti S. Rønningen; Cristian Guja; Constantin Ionescu-Tîrgovişte; David A. Savage; John A. Todd
Topics:
diabetes mellitus, type 1
,
genes
,
polymorphism
,
maturity onset diabetes mellitus in young
,
gene frequency
Diabetes April 2004, Vol.53, 1158-1161. doi:https://doi.org/10.2337/diabetes.53.4.1158
Association Between Variation in the Actin-Binding Gene Caldesmon and Diabetic Nephropathy in Type 1 Diabetes
Bryan R. Conway; A. Peter Maxwell; David A. Savage; Chris C. Patterson; Peter P. Doran; Madeline Murphy; Hugh R. Brady; Damian G. Fogarty
Topics:
actins
,
diabetes mellitus, type 1
,
diabetic nephropathy
,
genes
,
kidney diseases
Diabetes April 2004, Vol.53, 1162-1165. doi:https://doi.org/10.2337/diabetes.53.4.1162
Heritability of Multivariate Factors of the Metabolic Syndrome in Nondiabetic Japanese Americans
Melissa A. Austin; Karen L. Edwards; Marguerite J. McNeely; Wayne L. Chandler; Donna L. Leonetti; Philippa J. Talmud; Steve E. Humphries; Wilfred Y. Fujimoto
Topics:
c-reactive protein
,
glucose
,
insulin
,
loudness discomfort level
,
low-density lipoproteins
Diabetes April 2004, Vol.53, 1166-1169. doi:https://doi.org/10.2337/diabetes.53.4.1166
Linkage of the Metabolic Syndrome to 1q23-q31 in Hispanic Families : The Insulin Resistance Atherosclerosis Study Family Study
Carl D. Langefeld; Lynne E. Wagenknecht; Jerome I. Rotter; Adrienne H. Williams; John E. Hokanson; Mohammad F. Saad; Donald W. Bowden; Stephen Haffner; Jill M. Norris; Stephen S. Rich; Braxton D. Mitchell
Topics:
atherosclerosis
,
genetic pedigree
,
insulin resistance
,
metabolic syndrome x
,
family studies
Diabetes April 2004, Vol.53, 1170-1174. doi:https://doi.org/10.2337/diabetes.53.4.1170
Erratum
Erratum
Topics:
autoantibodies
,
immunoglobulin g4
,
antibodies
,
diabetes mellitus, type 1
,
reactive arthritis
Diabetes April 2004, Vol.53, 1175-1176. doi:https://doi.org/10.2337/diabetes.53.4.1175
Erratum
Topics:
advanced life support
,
amyotrophic lateral sclerosis
,
antilymphocyte globulin
,
diabetes mellitus, type 2
,
plasma glucose
Diabetes April 2004, Vol.53, 1177-1178. doi:https://doi.org/10.2337/diabetes.53.4.1177