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Metabolism

Inhalation of Insulin in Dogs: Assessment of Insulin Levels and Comparison to Subcutaneous Injection

Alan D. Cherrington; Doss W. Neal; Dale S. Edgerton; Dana Glass; Larry Bowen; Charles H. Hobbs; Chet Leach; Ralf Rosskamp; Thomas R. Strack

Abstract

View articletitled, Inhalation of Insulin in Dogs: Assessment of Insulin Levels and Comparison to Subcutaneous Injection

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Diabetes April 2004, Vol.53, 877-881. doi:https://doi.org/10.2337/diabetes.53.4.877

Signal Transduction

Modulation of Resistin Expression by Retinoic Acid and Vitamin A Status

Francisco Felipe; M. Luisa Bonet; Joan Ribot; Andreu Palou

Abstract

View articletitled, Modulation of Resistin Expression by Retinoic Acid and Vitamin A Status

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Diabetes April 2004, Vol.53, 882-889. doi:https://doi.org/10.2337/diabetes.53.4.882

Glucose Regulates the Expression of the Farnesoid X Receptor in Liver

Daniel Duran-Sandoval; Gisèle Mautino; Geneviève Martin; Fréderic Percevault; Olivier Barbier; Jean-Charles Fruchart; Folkert Kuipers; Bart Staels

Abstract

View articletitled, Glucose Regulates the Expression of the Farnesoid X Receptor in Liver

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Diabetes April 2004, Vol.53, 890-898. doi:https://doi.org/10.2337/diabetes.53.4.890

Protein Kinase B-α Inhibits Human Pyruvate Dehydrogenase Kinase-4 Gene Induction by Dexamethasone Through Inactivation of FOXO Transcription Factors

Hye-Sook Kwon; Boli Huang; Terry G. Unterman; Robert A. Harris

Abstract

View articletitled, Protein Kinase B-α Inhibits Human Pyruvate Dehydrogenase Kinase-4 Gene Induction by Dexamethasone Through Inactivation of FOXO Transcription Factors

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Diabetes April 2004, Vol.53, 899-910. doi:https://doi.org/10.2337/diabetes.53.4.899

Ciliary Neurotrophic Factor and Leptin Induce Distinct Patterns of Immediate Early Gene Expression in the Brain

Joseph F. Kelly; Carol F. Elias; Charlotte E. Lee; Rexford S. Ahima; Randy J. Seeley; Christian Bjørbæk; Takakazu Oka; Clifford B. Saper; Jeffrey S. Flier; Joel K. Elmquist

Abstracts

View articletitled, Ciliary Neurotrophic Factor and Leptin Induce Distinct Patterns of Immediate Early Gene Expression in the Brain

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Diabetes April 2004, Vol.53, 911-920. doi:https://doi.org/10.2337/diabetes.53.4.911

Prolonged Incubation in PUGNAc Results in Increased Protein O-Linked Glycosylation and Insulin Resistance in Rat Skeletal Muscle

Edward B. Arias; Junghoon Kim; Gregory D. Cartee

Abstract

View articletitled, Prolonged Incubation in PUGNAc Results in Increased Protein O-Linked Glycosylation and Insulin Resistance in Rat Skeletal Muscle

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Diabetes April 2004, Vol.53, 921-930. doi:https://doi.org/10.2337/diabetes.53.4.921

Obesity Study

Novel Adipose Tissue–Mediated Resistance to Diet-Induced Visceral Obesity in 11β-Hydroxysteroid Dehydrogenase Type 1–Deficient Mice

Nicholas M. Morton; Janice M. Paterson; Hiroaki Masuzaki; Megan C. Holmes; Bart Staels; Catherine Fievet; Brian R. Walker; Jeffrey S. Flier; John J. Mullins; Jonathan R. Seckl

Abstracts

View articletitled, Novel Adipose Tissue–Mediated Resistance to Diet-Induced Visceral Obesity in 11β-Hydroxysteroid Dehydrogenase Type 1–Deficient Mice

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Diabetes April 2004, Vol.53, 931-938. doi:https://doi.org/10.2337/diabetes.53.4.931

Restoration of Adiponectin Pulsatility in Severely Obese Subjects After Weight Loss

Menotti Calvani; Antonio Scarfone; Luigi Granato; Elena Valera Mora; Giuseppe Nanni; Marco Castagneto; Aldo V. Greco; Melania Manco; Geltrude Mingrone

Abstract

View articletitled, Restoration of Adiponectin Pulsatility in Severely Obese Subjects After Weight Loss

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Diabetes April 2004, Vol.53, 939-947. doi:https://doi.org/10.2337/diabetes.53.4.939

Immunology and Transplantation

Evidence of Functional Impairment of Syngeneically Transplanted Mouse Pancreatic Islets Retrieved from the Liver

Göran Mattsson; Leif Jansson; Astrid Nordin; Arne Andersson; Per-Ola Carlsson

Abstract

View articletitled, Evidence of Functional Impairment of Syngeneically Transplanted Mouse Pancreatic Islets Retrieved from the Liver

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Diabetes April 2004, Vol.53, 948-954. doi:https://doi.org/10.2337/diabetes.53.4.948

Assessment of the Severity of Hypoglycemia and Glycemic Lability in Type 1 Diabetic Subjects Undergoing Islet Transplantation

Edmond A. Ryan; Tami Shandro; Kristy Green; Breay W. Paty; Peter A. Senior; David Bigam; A.M. James Shapiro; Marie-Christine Vantyghem

Abstracts

View articletitled, Assessment of the Severity of Hypoglycemia and Glycemic Lability in Type 1 Diabetic Subjects Undergoing Islet Transplantation

Supplementary data

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Diabetes April 2004, Vol.53, 955-962. doi:https://doi.org/10.2337/diabetes.53.4.955

Elevated Vascular Endothelial Growth Factor Production in Islets Improves Islet Graft Vascularization

Nan Zhang; Anja Richter; Jenny Suriawinata; Sonal Harbaran; Jennifer Altomonte; Lin Cong; Haojiang Zhang; Keying Song; Marcia Meseck; Jonathan Bromberg; Hengjiang Dong

Abstract

View articletitled, Elevated Vascular Endothelial Growth Factor Production in Islets Improves Islet Graft Vascularization

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Diabetes April 2004, Vol.53, 963-970. doi:https://doi.org/10.2337/diabetes.53.4.963

Differential Recognition and Activation Thresholds in Human Autoreactive GAD-Specific T-Cells

Roberto Mallone; Sharon A. Kochik; Elsa M. Laughlin; Vivian H. Gersuk; Helena Reijonen; William W. Kwok; Gerald T. Nepom

Abstract

View articletitled, Differential Recognition and Activation Thresholds in Human Autoreactive GAD-Specific T-Cells

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Diabetes April 2004, Vol.53, 971-977. doi:https://doi.org/10.2337/diabetes.53.4.971

T-Cell Receptor Transgenic Response to an Endogenous Polymorphic Autoantigen Determines Susceptibility to Diabetes

Mary E. Pauza; Cathleen M. Dobbs; Jing He; Tricia Patterson; Steven Wagner; Brian S. Anobile; Brenda J. Bradley; David Lo; Kathryn Haskins

Abstracts

View articletitled, T-Cell Receptor Transgenic Response to an Endogenous Polymorphic Autoantigen Determines Susceptibility to Diabetes

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Diabetes April 2004, Vol.53, 978-988. doi:https://doi.org/10.2337/diabetes.53.4.978

Islet Study

Improved Islet Morphology after Blockade of the Renin- Angiotensin System in the ZDF Rat

Christos Tikellis; Peter J. Wookey; Riccardo Candido; Sof Andrikopoulos; Merlin C. Thomas; Mark E. Cooper

Abstract

View articletitled, Improved Islet Morphology after Blockade of the Renin- Angiotensin System in the ZDF Rat

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Diabetes April 2004, Vol.53, 989-997. doi:https://doi.org/10.2337/diabetes.53.4.989

Metabotropic Glutamate Receptor Type 4 Is Involved in Autoinhibitory Cascade for Glucagon Secretion by α-Cells of Islet of Langerhans

Shunsuke Uehara; Akiko Muroyama; Noriko Echigo; Riyo Morimoto; Masato Otsuka; Shouki Yatsushiro; Yoshinori Moriyama

Abstracts

View articletitled, Metabotropic Glutamate Receptor Type 4 Is Involved in Autoinhibitory Cascade for Glucagon Secretion by α-Cells of Islet of Langerhans

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Diabetes April 2004, Vol.53, 998-1006. doi:https://doi.org/10.2337/diabetes.53.4.998

A Role for the Malonyl-CoA/Long-Chain Acyl-CoA Pathway of Lipid Signaling in the Regulation of Insulin Secretion in Response to Both Fuel and Nonfuel Stimuli

Raphaël Roduit; Christopher Nolan; Cristina Alarcon; Patrick Moore; Annie Barbeau; Viviane Delghingaro-Augusto; Ewa Przybykowski; Johane Morin; Frédéric Massé; Bernard Massie; Neil Ruderman; Christopher Rhodes; Vincent Poitout; Marc Prentki

Abstracts

View articletitled, A Role for the Malonyl-CoA/Long-Chain Acyl-CoA Pathway of Lipid Signaling in the Regulation of Insulin Secretion in Response to Both Fuel and Nonfuel Stimuli

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Diabetes April 2004, Vol.53, 1007-1019. doi:https://doi.org/10.2337/diabetes.53.4.1007

Interaction of 6-Phosphofructo-2-Kinase/Fructose-2,6-Bisphosphatase (PFK-2/FBPase-2) With Glucokinase Activates Glucose Phosphorylation and Glucose Metabolism in Insulin-Producing Cells

Laura Massa; Simone Baltrusch; David A. Okar; Alex J. Lange; Sigurd Lenzen; Markus Tiedge

Abstracts

View articletitled, Interaction of 6-Phosphofructo-2-Kinase/Fructose-2,6-Bisphosphatase (PFK-2/FBPase-2) With Glucokinase Activates Glucose Phosphorylation and Glucose Metabolism in Insulin-Producing Cells

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Diabetes April 2004, Vol.53, 1020-1029. doi:https://doi.org/10.2337/diabetes.53.4.1020

Regulated Expression of pdx-1 Promotes In Vitro Differentiation of Insulin-Producing Cells From Embryonic Stem Cells

Satsuki Miyazaki; Eiji Yamato; Jun-ichi Miyazaki

Abstract

View articletitled, Regulated Expression of pdx-1 Promotes In Vitro Differentiation of Insulin-Producing Cells From Embryonic Stem Cells

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Diabetes April 2004, Vol.53, 1030-1037. doi:https://doi.org/10.2337/diabetes.53.4.1030

Glucose Inhibition of Glucagon Secretion From Rat α-Cells Is Mediated by GABA Released From Neighboring β-Cells

Anna Wendt; Bryndis Birnir; Karsten Buschard; Jesper Gromada; Albert Salehi; Sabine Sewing; Patrik Rorsman; Matthias Braun

Abstract

View articletitled, Glucose Inhibition of Glucagon Secretion From Rat α-Cells Is Mediated by GABA Released From Neighboring β-Cells

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Diabetes April 2004, Vol.53, 1038-1045. doi:https://doi.org/10.2337/diabetes.53.4.1038

Pathophysiology

Diabetic Patients Without Vascular Complications Display Enhanced Basal Platelet Activation and Decreased Antioxidant Status

Evelyne Véricel; Caroline Januel; Martine Carreras; Philippe Moulin; Michel Lagarde

Abstract

View articletitled, Diabetic Patients Without Vascular Complications Display Enhanced Basal Platelet Activation and Decreased Antioxidant Status

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Diabetes April 2004, Vol.53, 1046-1051. doi:https://doi.org/10.2337/diabetes.53.4.1046

Thiazolidinediones, Like Metformin, Inhibit Respiratory Complex I: A Common Mechanism Contributing to Their Antidiabetic Actions?

Barbara Brunmair; Katrin Staniek; Florian Gras; Nicole Scharf; Aleksandra Althaym; Renate Clara; Michael Roden; Erich Gnaiger; Hans Nohl; Werner Waldhäusl; Clemens Fürnsinn

Abstract

View articletitled, Thiazolidinediones, Like Metformin, Inhibit Respiratory Complex I: A Common Mechanism Contributing to Their Antidiabetic Actions?

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Diabetes April 2004, Vol.53, 1052-1059. doi:https://doi.org/10.2337/diabetes.53.4.1052

Differential Effects of Interleukin-6 and -10 on Skeletal Muscle and Liver Insulin Action In Vivo

Hyo-Jeong Kim; Takamasa Higashimori; So-Young Park; Hyejeong Choi; Jianying Dong; Yoon-Jung Kim; Hye-Lim Noh; You-Ree Cho; Gary Cline; Young-Bum Kim; Jason K. Kim

Abstract

View articletitled, Differential Effects of Interleukin-6 and -10 on Skeletal Muscle and Liver Insulin Action In Vivo

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Diabetes April 2004, Vol.53, 1060-1067. doi:https://doi.org/10.2337/diabetes.53.4.1060

The Metabolic Syndrome, Circulating Oxidized LDL, and Risk of Myocardial Infarction in Well-Functioning Elderly People in the Health, Aging, and Body Composition Cohort

Paul Holvoet; Stephen B. Kritchevsky; Russell P. Tracy; Ann Mertens; Susan M. Rubin; Javed Butler; Bret Goodpaster; Tamara B. Harris

Abstract

View articletitled, The Metabolic Syndrome, Circulating Oxidized LDL, and Risk of Myocardial Infarction in Well-Functioning Elderly People in the Health, Aging, and Body Composition Cohort

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Diabetes April 2004, Vol.53, 1068-1073. doi:https://doi.org/10.2337/diabetes.53.4.1068

Hexosamine Pathway Is Responsible for Inhibition by Diabetes of Phenylephrine-Induced Inotropy

Yi Pang; Pam Bounelis; John C. Chatham; Richard B. Marchase

Abstract

View articletitled, Hexosamine Pathway Is Responsible for Inhibition by Diabetes of Phenylephrine-Induced Inotropy

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Diabetes April 2004, Vol.53, 1074-1081. doi:https://doi.org/10.2337/diabetes.53.4.1074

Oxidative Stress Impairs Skeletal Muscle Repair in Diabetic Rats

Manuela Aragno; Raffaella Mastrocola; Maria Graziella Catalano; Enrico Brignardello; Oliviero Danni; Giuseppe Boccuzzi

Abstract

View articletitled, Oxidative Stress Impairs Skeletal Muscle Repair in Diabetic Rats

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Diabetes April 2004, Vol.53, 1082-1088. doi:https://doi.org/10.2337/diabetes.53.4.1082

Improved β-Cell Survival and Reduced Insulitis in a Type 1 Diabetic Rat Model After Treatment With a β-Cell–Selective K_ATP Channel Opener

Kresten Skak; Carsten F. Gotfredsen; Dorthe Lundsgaard; John Bondo Hansen; Jeppe Sturis; Helle Markholst

Abstract

View articletitled, Improved β-Cell Survival and Reduced Insulitis in a Type 1 Diabetic Rat Model After Treatment With a β-Cell–Selective KATP Channel Opener

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Diabetes April 2004, Vol.53, 1089-1095. doi:https://doi.org/10.2337/diabetes.53.4.1089

Complication

Prophylactic Gene Therapy With Human Tissue Kallikrein Ameliorates Limb Ischemia Recovery in Type 1 Diabetic Mice

Costanza Emanueli; Galliam Graiani; Maria B. Salis; Sergio Gadau; Elisa Desortes; Paolo Madeddu

Abstract

View articletitled, Prophylactic Gene Therapy With Human Tissue Kallikrein Ameliorates Limb Ischemia Recovery in Type 1 Diabetic Mice

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Diabetes April 2004, Vol.53, 1096-1103. doi:https://doi.org/10.2337/diabetes.53.4.1096

Angiopoietin-2 Causes Pericyte Dropout in the Normal Retina: Evidence for Involvement in Diabetic Retinopathy

Hans-Peter Hammes; Jihong Lin; Patrick Wagner; Yuxi Feng; Franziska vom Hagen; Thomas Krzizok; Oliver Renner; Georg Breier; Michael Brownlee; Urban Deutsch

Abstract

View articletitled, Angiopoietin-2 Causes Pericyte Dropout in the Normal Retina: Evidence for Involvement in Diabetic Retinopathy

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Diabetes April 2004, Vol.53, 1104-1110. doi:https://doi.org/10.2337/diabetes.53.4.1104

Transforming Growth Factor-β1 Production Is Correlated With Genetically Determined ACE Expression in Congenic Rats: A Possible Link Between ACE Genotype and Diabetic Nephropathy

Maria E. Pueyo; Mireille Challah; Dominique Gauguier; Liliane Louedec; Monique Philippe; Roger Gaertner; Michel Marre; Jean-Baptiste Michel; Marie-Paule Jacob

Abstract

View articletitled, Transforming Growth Factor-β1 Production Is Correlated With Genetically Determined ACE Expression in Congenic Rats: A Possible Link Between ACE Genotype and Diabetic Nephropathy

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Diabetes April 2004, Vol.53, 1111-1118. doi:https://doi.org/10.2337/diabetes.53.4.1111

Regression of Advanced Diabetic Nephropathy by Hepatocyte Growth Factor Gene Therapy in Rats

Josep M. Cruzado; Núria Lloberas; Joan Torras; Marta Riera; Cristina Fillat; Immaculada Herrero-Fresneda; Josep M. Aran; Gabriela Alperovich; August Vidal; Josep M. Grinyó

Abstract

View articletitled, Regression of Advanced Diabetic Nephropathy by Hepatocyte Growth Factor Gene Therapy in Rats

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Diabetes April 2004, Vol.53, 1119-1127. doi:https://doi.org/10.2337/diabetes.53.4.1119

Genetics

Maternal-Fetal Interactions and Birth Order Influence Insulin Variable Number of Tandem Repeats Allele Class Associations with Head Size at Birth and Childhood Weight Gain

Ken K. Ong; Clive J. Petry; Bryan J. Barratt; Susan Ring; Heather J. Cordell; Diane L. Wingate; the Avon Longitudinal Study of Pregnancy and Childhood Study Team; Marcus E. Pembrey; John A. Todd; David B. Dunger

Abstract

View articletitled, Maternal-Fetal Interactions and Birth Order Influence Insulin Variable Number of Tandem Repeats Allele Class Associations with Head Size at Birth and Childhood Weight Gain

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Diabetes April 2004, Vol.53, 1128-1133. doi:https://doi.org/10.2337/diabetes.53.4.1128

A Common Polymorphism in the Upstream Promoter Region of the Hepatocyte Nuclear Factor-4α Gene on Chromosome 20q Is Associated With Type 2 Diabetes and Appears to Contribute to the Evidence for Linkage in an Ashkenazi Jewish Population

Latisha D. Love-Gregory; Jonathon Wasson; Jiyan Ma; Carol H. Jin; Benjamin Glaser; Brian K. Suarez; M. Alan Permutt

Abstracts

View articletitled, A Common Polymorphism in the Upstream Promoter Region of the Hepatocyte Nuclear Factor-4α Gene on Chromosome 20q Is Associated With Type 2 Diabetes and Appears to Contribute to the Evidence for Linkage in an Ashkenazi Jewish Population

Supplementary data

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Diabetes April 2004, Vol.53, 1134-1140. doi:https://doi.org/10.2337/diabetes.53.4.1134

Genetic Variation Near the Hepatocyte Nuclear Factor-4α Gene Predicts Susceptibility to Type 2 Diabetes

Abstracts

View articletitled, Genetic Variation Near the Hepatocyte Nuclear Factor-4α Gene Predicts Susceptibility to Type 2 Diabetes

Supplementary data

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Diabetes April 2004, Vol.53, 1141-1149. doi:https://doi.org/10.2337/diabetes.53.4.1141

Brief Genetics Report

Adiponectin Gene Polymorphisms and Adiponectin Levels Are Independently Associated With the Development of Hyperglycemia During a 3-Year Period: The Epidemiologic Data on the Insulin Resistance Syndrome Prospective Study

Frédéric Fumeron; Roberte Aubert; Afshan Siddiq; Dina Betoulle; Frank Péan; Samy Hadjadj; Jean Tichet; Elsie Wilpart; Marie-Claude Chesnier; Beverley Balkau; Philippe Froguel; Michel Marre; for the Epidemiologic Data on the Insulin Resistance Syndrome (DESIR) Study Group

Abstracts

View articletitled, Adiponectin Gene Polymorphisms and Adiponectin Levels Are Independently Associated With the Development of Hyperglycemia During a 3-Year Period: The Epidemiologic Data on the Insulin Resistance Syndrome Prospective Study

Supplementary data

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Diabetes April 2004, Vol.53, 1150-1157. doi:https://doi.org/10.2337/diabetes.53.4.1150

Lack of Association of the Ala⁴⁵Thr Polymorphism and Other Common Variants of the NeuroD Gene With Type 1 Diabetes

Adrian Vella; Joanna M.M. Howson; Bryan J. Barratt; Rebecca C.J. Twells; Helen E. Rance; Sarah Nutland; Eva Tuomilehto-Wolf; Jaakko Tuomilehto; Dag E. Undlien; Kjersti S. Rønningen; Cristian Guja; Constantin Ionescu-Tîrgovişte; David A. Savage; John A. Todd

Abstracts

View articletitled, Lack of Association of the Ala45Thr Polymorphism and Other Common Variants of the NeuroD Gene With Type 1 Diabetes

Supplementary data

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Diabetes April 2004, Vol.53, 1158-1161. doi:https://doi.org/10.2337/diabetes.53.4.1158

Association Between Variation in the Actin-Binding Gene Caldesmon and Diabetic Nephropathy in Type 1 Diabetes

Bryan R. Conway; A. Peter Maxwell; David A. Savage; Chris C. Patterson; Peter P. Doran; Madeline Murphy; Hugh R. Brady; Damian G. Fogarty

Abstract

View articletitled, Association Between Variation in the Actin-Binding Gene Caldesmon and Diabetic Nephropathy in Type 1 Diabetes

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Diabetes April 2004, Vol.53, 1162-1165. doi:https://doi.org/10.2337/diabetes.53.4.1162

Heritability of Multivariate Factors of the Metabolic Syndrome in Nondiabetic Japanese Americans

Melissa A. Austin; Karen L. Edwards; Marguerite J. McNeely; Wayne L. Chandler; Donna L. Leonetti; Philippa J. Talmud; Steve E. Humphries; Wilfred Y. Fujimoto

Abstract

View articletitled, Heritability of Multivariate Factors of the Metabolic Syndrome in Nondiabetic Japanese Americans

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Diabetes April 2004, Vol.53, 1166-1169. doi:https://doi.org/10.2337/diabetes.53.4.1166

Linkage of the Metabolic Syndrome to 1q23-q31 in Hispanic Families : The Insulin Resistance Atherosclerosis Study Family Study

Carl D. Langefeld; Lynne E. Wagenknecht; Jerome I. Rotter; Adrienne H. Williams; John E. Hokanson; Mohammad F. Saad; Donald W. Bowden; Stephen Haffner; Jill M. Norris; Stephen S. Rich; Braxton D. Mitchell

Abstract

View articletitled, Linkage of the Metabolic Syndrome to 1q23-q31 in Hispanic Families : The Insulin Resistance Atherosclerosis Study Family Study

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Diabetes April 2004, Vol.53, 1170-1174. doi:https://doi.org/10.2337/diabetes.53.4.1170

Erratum

Extract

View articletitled, Erratum

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Diabetes April 2004, Vol.53, 1175-1176. doi:https://doi.org/10.2337/diabetes.53.4.1175

Erratum

Extract

View articletitled, Erratum

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Diabetes April 2004, Vol.53, 1177-1178. doi:https://doi.org/10.2337/diabetes.53.4.1177

Issues

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Signal Transduction

Obesity Study

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