Issues

Topics: diabetes mellitus, type 2 , genetics , obesity

Diabetes May 2004, Vol.53, 1181-1186. doi:https://doi.org/10.2337/diabetes.53.5.1181

Metabolism

One Week’s Treatment With the Long-Acting Glucagon-Like Peptide 1 Derivative Liraglutide (NN2211) Markedly Improves 24-h Glycemia and α- and β-Cell Function and Reduces Endogenous Glucose Release in Patients with Type 2 Diabetes

Kristine B. Degn; Claus B. Juhl; Jeppe Sturis; Grethe Jakobsen; Birgitte Brock; Visvanathan Chandramouli; Joergen Rungby; Bernard R. Landau; Ole Schmitz

Abstract

Topics: diabetes mellitus, type 2 , glucagon-like peptide 1 , glucose , insulin , liraglutide

Diabetes May 2004, Vol.53, 1187-1194. doi:https://doi.org/10.2337/diabetes.53.5.1187

Relationship to Insulin Resistance of the Adult Treatment Panel III Diagnostic Criteria for Identification of the Metabolic Syndrome

Karen L. Cheal; Fahim Abbasi; Cindy Lamendola; Tracey McLaughlin; Gerald M. Reaven; Earl S. Ford

Abstract

Topics: adult treatment panel iii , insulin , insulin resistance , metabolic syndrome x , hypertension

Diabetes May 2004, Vol.53, 1195-1200. doi:https://doi.org/10.2337/diabetes.53.5.1195

Evaluation of Insulin Sensitivity and β-Cell Function Indexes Obtained From Minimal Model Analysis of a Meal Tolerance Test

Garry M. Steil; Chi-min Hwu; Robert Janowski; Farzam Hariri; Sujata Jinagouda; Christine Darwin; Sameh Tadros; Kerstin Rebrin; Mohammed F. Saad

Abstracts

Topics: glucose , insulin , insulin secretion , insulin sensitivity , plasma glucose

Diabetes May 2004, Vol.53, 1201-1207. doi:https://doi.org/10.2337/diabetes.53.5.1201

Signal Transduction

Exercise and Myocyte Enhancer Factor 2 Regulation in Human Skeletal Muscle

Sean L. McGee; Mark Hargreaves

Abstract

Topics: mef2 transcription factors , skeletal muscles

Diabetes May 2004, Vol.53, 1208-1214. doi:https://doi.org/10.2337/diabetes.53.5.1208

Relationship Between Insulin Sensitivity and Sphingomyelin Signaling Pathway in Human Skeletal Muscle

Marek Straczkowski; Irina Kowalska; Agnieszka Nikolajuk; Stella Dzienis-Straczkowska; Ida Kinalska; Marcin Baranowski; Malgorzata Zendzian-Piotrowska; Zofia Brzezinska; Jan Gorski

Abstract

Topics: ceramides , fatty acids , heparin , infusion procedures , insulin

Diabetes May 2004, Vol.53, 1215-1221. doi:https://doi.org/10.2337/diabetes.53.5.1215

Bifunctional Properties of Peroxisome Proliferator-Activated Receptor γ1 in KDR Gene Regulation Mediated via Interaction With Both Sp1 and Sp3

Yukio Sassa; Yasuaki Hata; Lloyd Paul Aiello; Yukio Taniguchi; Kimitoshi Kohno; Tatsuro Ishibashi

Abstracts

Topics: ligands , peroxisome proliferator-activated receptors , dna , dinoprost , promoter regions (genetics)

Diabetes May 2004, Vol.53, 1222-1229. doi:https://doi.org/10.2337/diabetes.53.5.1222

Third Ventricular Alloxan Reversibly Impairs Glucose Counterregulatory Responses

Nicole M. Sanders; Ambrose A. Dunn-Meynell; Barry E. Levin

Abstract

Topics: alloxan , saline solutions , glucose , rats , hypothalamus

Diabetes May 2004, Vol.53, 1230-1236. doi:https://doi.org/10.2337/diabetes.53.5.1230

Obesity Study

Effects of Diabetes and Insulin on the Expression of Galanin-Like Peptide in the Hypothalamus of the Rat

Gregory S. Fraley; Jarrad M. Scarlett; Issei Shimada; Dawit N. Teklemichael; Blake V. Acohido; Donald K. Clifton; Robert A. Steiner

Abstract

Topics: insulin , leptin , rna, messenger , galanin , peptides

Diabetes May 2004, Vol.53, 1237-1242. doi:https://doi.org/10.2337/diabetes.53.5.1237

Adipose Tissue Expression of the Lipid Droplet–Associating Proteins S3-12 and Perilipin Is Controlled by Peroxisome Proliferator–Activated Receptor-γ

Knut Tomas Dalen; Kristina Schoonjans; Stine M. Ulven; Mina Susanne Weedon-Fekjaer; Trine Gjesti Bentzen; Hana Koutnikova; Johan Auwerx; Hilde I. Nebb

Abstracts

Topics: adipophilin , perilipin , peroxisome proliferator-activated receptors , third heart sound , obesity

Diabetes May 2004, Vol.53, 1243-1252. doi:https://doi.org/10.2337/diabetes.53.5.1243

Triglycerides Induce Leptin Resistance at the Blood-Brain Barrier

William A. Banks; Alan B. Coon; Sandra M. Robinson; Asif Moinuddin; Jessica M. Shultz; Ryota Nakaoke; John E. Morley

Abstract

Topics: brain , leptin , mice , triglycerides , obesity

Diabetes May 2004, Vol.53, 1253-1260. doi:https://doi.org/10.2337/diabetes.53.5.1253

Role of Caveolin-1 in the Modulation of Lipolysis and Lipid Droplet Formation

Alex W. Cohen; Babak Razani; William Schubert; Terence M. Williams; Xiao Bo Wang; Puneeth Iyengar; Dawn L. Brasaemle; Philipp E. Scherer; Michael P. Lisanti

Abstract

Topics: caveolins , perilipin

Diabetes May 2004, Vol.53, 1261-1270. doi:https://doi.org/10.2337/diabetes.53.5.1261

Effects of Dietary Monosaccharides on Sympathetic Nervous System Activity in Adipose Tissues of Male Rats

James B. Young; Jeffrey Weiss; Nadine Boufath

Abstract

Topics: diet , fructose , galactose , glucose , monosaccharides

Diabetes May 2004, Vol.53, 1271-1278. doi:https://doi.org/10.2337/diabetes.53.5.1271

High Serum Resistin Is Associated With an Increase in Adiposity But Not a Worsening of Insulin Resistance in Pima Indians

Barbora Vozarova de Courten; Mikako Degawa-Yamauchi; Robert V. Considine; P. Antonio Tataranni

Abstract

Topics: insulin , insulin resistance , obesity , resistin , glucose

Diabetes May 2004, Vol.53, 1279-1284. doi:https://doi.org/10.2337/diabetes.53.5.1279

From Blood Monocytes to Adipose Tissue-Resident Macrophages: Induction of Diapedesis by Human Mature Adipocytes

Cyrile A. Curat; Alexandra Miranville; Coralie Sengenès; Michael Diehl; Carolin Tonus; Rudi Busse; Anne Bouloumié

Abstract

Topics: adipocytes , electroconvulsive therapy , epidural cortical stimulation , macrophages , monocytes

Diabetes May 2004, Vol.53, 1285-1292. doi:https://doi.org/10.2337/diabetes.53.5.1285

Immunology and Transplantation

Islet Cell Autoimmunity in a Triethnic Adult Population of the Third National Health and Nutrition Examination Survey

Emma Barinas-Mitchell; Susan Pietropaolo; Ying-Jian Zhang; Tyona Henderson; Massimo Trucco; Lewis H. Kuller; Massimo Pietropaolo

Abstract

Topics: acute aortic syndrome , anabolic steroids , autoimmunity , c-peptide , endocrine pancreas

Diabetes May 2004, Vol.53, 1293-1302. doi:https://doi.org/10.2337/diabetes.53.5.1293

Interleukin-4 but not Interleukin-10 Protects Against Spontaneous and Recurrent Type 1 Diabetes by Activated CD1d-Restricted Invariant Natural Killer T-Cells

Qing-Sheng Mi; Dalam Ly; Peter Zucker; Megan McGarry; Terry L. Delovitch

Abstracts

Topics: diabetes mellitus, type 1 , interleukin-10 , interleukin-4 , mice , mice, inbred nod

Diabetes May 2004, Vol.53, 1303-1310. doi:https://doi.org/10.2337/diabetes.53.5.1303

Prevalence of Hepatic Steatosis After Islet Transplantation and Its Relation to Graft Function

Ravi Bhargava; Peter A. Senior; Thomas E. Ackerman; Edmond A. Ryan; Breay W. Paty; Jonathan R.T. Lakey; A.M. James Shapiro

Abstracts

Topics: c-peptide , diagnostic imaging , fatty degeneration , fatty liver , insulin

Diabetes May 2004, Vol.53, 1311-1317. doi:https://doi.org/10.2337/diabetes.53.5.1311

Intraislet Endothelial Cells Contribute to Revascularization of Transplanted Pancreatic Islets

Marcela Brissova; Michael Fowler; Peter Wiebe; Alena Shostak; Masakazu Shiota; Aramandla Radhika; P. Charles Lin; Maureen Gannon; Alvin C. Powers

Abstracts

Topics: endothelial cells , mice , revascularization , tissue transplants , transplantation

Diabetes May 2004, Vol.53, 1318-1325. doi:https://doi.org/10.2337/diabetes.53.5.1318

Islet Study

Double Incretin Receptor Knockout (DIRKO) Mice Reveal an Essential Role for the Enteroinsular Axis in Transducing the Glucoregulatory Actions of DPP-IV Inhibitors

Tanya Hansotia; Laurie L. Baggio; Dominique Delmeire; Simon A. Hinke; Yuichiro Yamada; Katsushi Tsukiyama; Yutaka Seino; Jens J. Holst; Frans Schuit; D.J. Drucker

Abstracts

Topics: dipeptidyl-peptidase iv inhibitors , glucagon-like peptide 1 , glucose , incretin , insulin

Diabetes May 2004, Vol.53, 1326-1335. doi:https://doi.org/10.2337/diabetes.53.5.1326

Pathophysiology

Catalase Protects Cardiomyocyte Function in Models of Type 1 and Type 2 Diabetes

Gang Ye; Naira S. Metreveli; Rajakumar V. Donthi; Shen Xia; Ming Xu; Edward C. Carlson; Paul N. Epstein

Abstract

Topics: cardiac myocytes , catalase , diabetes mellitus, type 2 , muscle cells , heart

Diabetes May 2004, Vol.53, 1336-1343. doi:https://doi.org/10.2337/diabetes.53.5.1336

Complication

Insulin Generates Free Radicals by an NAD(P)H, Phosphatidylinositol 3′-Kinase-Dependent Mechanism in Human Skin Fibroblasts Ex Vivo

Giulio Ceolotto; Michela Bevilacqua; Italia Papparella; Elisabetta Baritono; Lorenzo Franco; Carlo Corvaja; Martina Mazzoni; Andrea Semplicini; Angelo Avogaro

Abstract

Topics: free radicals , insulin , phosphotransferases , fibroblasts

Diabetes May 2004, Vol.53, 1344-1351. doi:https://doi.org/10.2337/diabetes.53.5.1344

Cerebrovascular Dysfunction in Zucker Obese Rats Is Mediated by Oxidative Stress and Protein Kinase C

Benedek Erdös; James A. Snipes; Allison W. Miller; David W. Busija

Abstract

Topics: dilators , rats , nitric oxide synthase , protein kinase c , obesity

Diabetes May 2004, Vol.53, 1352-1359. doi:https://doi.org/10.2337/diabetes.53.5.1352

Genetics

Haplotype Structure and Genotype-Phenotype Correlations of the Sulfonylurea Receptor and the Islet ATP-Sensitive Potassium Channel Gene Region

Jose C. Florez; Noël Burtt; Paul I.W. de Bakker; Peter Almgren; Tiinamaija Tuomi; Johan Holmkvist; Daniel Gaudet; Thomas J. Hudson; Steve F. Schaffner; Mark J. Daly; Joel N. Hirschhorn; Leif Groop; David Altshuler

Abstracts

Topics: abcc8 gene , diabetes mellitus, type 2 , genes , genotype , haplotypes

Diabetes May 2004, Vol.53, 1360-1368. doi:https://doi.org/10.2337/diabetes.53.5.1360

Genome-Wide Scans Reveal Quantitative Trait Loci on 8p and 13q Related to Insulin Action and Glucose Metabolism: The San Antonio Family Heart Study

Guowen Cai; Shelley A. Cole; Jeanne H. Freeland-Graves; Jean W. MacCluer; John Blangero; Anthony G. Comuzzie

Abstract

Topics: glucose , insulin , fasting blood glucose measurement , diabetes mellitus, type 2 , quantitative trait loci

Diabetes May 2004, Vol.53, 1369-1374. doi:https://doi.org/10.2337/diabetes.53.5.1369

Identification of a Locus for Maturity-Onset Diabetes of the Young on Chromosome 8p23

Sung-Hoon Kim; Xiaowei Ma; Stanislawa Weremowicz; Tonino Ercolino; Christine Powers; Wojciech Mlynarski; K. Aviva Bashan; James H. Warram; Josyf Mychaleckyj; Stephen S. Rich; Andrzej S. Krolewski; Alessandro Doria

Abstracts

Topics: chromosomes , diabetes mellitus, type 2 , genes , genome , maturity onset diabetes mellitus in young

Diabetes May 2004, Vol.53, 1375-1384. doi:https://doi.org/10.2337/diabetes.53.5.1375

Complex Haplotypes of the PGC-1α Gene Are Associated With Carbohydrate Metabolism and Type 2 Diabetes

Hannes Oberkofler; Veronika Linnemayr; Raimund Weitgasser; Kerstin Klein; Mingqiang Xie; Bernhard Iglseder; Franz Krempler; Bernhard Paulweber; Wolfgang Patsch

Abstracts

Topics: alleles , diabetes mellitus, type 2 , genes , glucose , haplotypes

Diabetes May 2004, Vol.53, 1385-1393. doi:https://doi.org/10.2337/diabetes.53.5.1385

Brief Genetics Report

Investigation of the Human ANP Gene in Type 1 Diabetic Nephropathy: Case-Control and Follow-up Studies

Ronan Roussel; David-Alexandre Trégouët; Samy Hadjadj; Xavier Jeunemaı̂tre; Michel Marre

Abstracts

Topics: diabetic nephropathy , follow-up , genes , kidney diseases , haplotypes

Diabetes May 2004, Vol.53, 1394-1398. doi:https://doi.org/10.2337/diabetes.53.5.1394

Genome-Wide Linkage to Chromosome 6 for Waist Circumference in the Framingham Heart Study

Caroline S. Fox; Nancy L. Heard-Costa; Peter W.F. Wilson; Daniel Levy; Ralph B. D’Agostino, Sr.; Larry D. Atwood

Abstract

Topics: framingham heart study , genome , obesity , waist circumference , chromosomes, human, pair 6

Diabetes May 2004, Vol.53, 1399-1402. doi:https://doi.org/10.2337/diabetes.53.5.1399

Letter to the Editor

Status of Research Funding by the American Diabetes Association—5th and Final Year

Mayer B. Davidson, MD

Extract

Topics: awards and prizes , metaphor , ships

Diabetes May 2004, Vol.53, 1403. doi:https://doi.org/10.2337/diabetes.53.5.1403

Erratum

Extract