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Volume 53, Issue 8
1 August 2004
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ISSN 0012-1797
EISSN 1939-327X
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Rapid Publication

Abnormal Glucose Homeostasis due to Chronic Hyperresistinemia
Shamina M. Rangwala; A. Sophie Rich; Ben Rhoades; Jennifer S. Shapiro; Silvana Obici; Luciano Rossetti; Mitchell A. Lazar
View articletitled, Abnormal Glucose Homeostasis due to Chronic Hyperresistinemia
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Diabetes August 2004, Vol.53, 1937-1941. doi:https://doi.org/10.2337/diabetes.53.8.1937

Perspectives in Diabetes

Does the Glucose-Dependent Insulin Secretion Mechanism Itself Cause Oxidative Stress in Pancreatic β-Cells?
Leonid E. Fridlyand; Louis H. Philipson
View articletitled, Does the Glucose-Dependent Insulin Secretion Mechanism Itself Cause Oxidative Stress in Pancreatic β-Cells?
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Diabetes August 2004, Vol.53, 1942-1948. doi:https://doi.org/10.2337/diabetes.53.8.1942

Signal Transduction

PYY3–36 Reinforces Insulin Action on Glucose Disposal in Mice Fed a High-Fat Diet
Anita M. van den Hoek; Annemieke C. Heijboer; Eleonora P.M. Corssmit; Peter J. Voshol; Johannes A. Romijn; Louis M. Havekes; Hanno Pijl
View articletitled, PYY<sub>3–36</sub> Reinforces Insulin Action on Glucose Disposal in Mice Fed a High-Fat Diet
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Diabetes August 2004, Vol.53, 1949-1952. doi:https://doi.org/10.2337/diabetes.53.8.1949
Potential Role for AMP-Activated Protein Kinase in Hypoglycemia Sensing in the Ventromedial Hypothalamus
Rory J. McCrimmon; Xiaoning Fan; Yuyan Ding; Wanling Zhu; Ralph J. Jacob; Robert S. Sherwin
View articletitled, Potential Role for AMP-Activated Protein Kinase in Hypoglycemia Sensing in the Ventromedial Hypothalamus
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Diabetes August 2004, Vol.53, 1953-1958. doi:https://doi.org/10.2337/diabetes.53.8.1953

Obesity Studies

The Regulation of Glucose-Excited Neurons in the Hypothalamic Arcuate Nucleus by Glucose and Feeding-Relevant Peptides
R. Wang; X. Liu; S.T. Hentges; A.A. Dunn-Meynell; B.E. Levin; W. Wang; V.H. Routh
View articletitled, The Regulation of Glucose-Excited Neurons in the Hypothalamic Arcuate Nucleus by Glucose and Feeding-Relevant Peptides
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Diabetes August 2004, Vol.53, 1959-1965. doi:https://doi.org/10.2337/diabetes.53.8.1959
Effects of Different Hypocaloric Diets on Protein Secretion From Adipose Tissue of Obese Women
Elisabet Arvidsson; Nathalie Viguerie; Ingalena Andersson; Camilla Verdich; Dominique Langin; Peter Arner
View articletitled, Effects of Different Hypocaloric Diets on Protein Secretion From Adipose Tissue of Obese Women
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Diabetes August 2004, Vol.53, 1966-1971. doi:https://doi.org/10.2337/diabetes.53.8.1966

Immunology and Transplantation

Islet Allograft Survival Induced by Costimulation Blockade in NOD Mice Is Controlled by Allelic Variants of Idd3
Todd Pearson; Peter Weiser; Thomas G. Markees; David V. Serreze; Linda S. Wicker; Laurence B. Peterson; Anne-Marie Cumisky; Leonard D. Shultz; John P. Mordes; Aldo A. Rossini; Dale L. Greiner
View articletitled, Islet Allograft Survival Induced by Costimulation Blockade in NOD Mice Is Controlled by Allelic Variants of <em>Idd3</em>
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Diabetes August 2004, Vol.53, 1972-1978. doi:https://doi.org/10.2337/diabetes.53.8.1972
Increased Serum Levels of MRP-8/14 in Type 1 Diabetes Induce an Increased Expression of CD11b and an Enhanced Adhesion of Circulating Monocytes to Fibronectin
Gerben Bouma; Wai Kwan Lam-Tse; Annet F. Wierenga-Wolf; Hemmo A. Drexhage; Marjan A. Versnel
View articletitled, Increased Serum Levels of MRP-8/14 in Type 1 Diabetes Induce an Increased Expression of CD11b and an Enhanced Adhesion of Circulating Monocytes to Fibronectin
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Diabetes August 2004, Vol.53, 1979-1986. doi:https://doi.org/10.2337/diabetes.53.8.1979
GAD65-Specific CD4+ T-Cells with High Antigen Avidity Are Prevalent in Peripheral Blood of Patients With Type 1 Diabetes
Helena Reijonen; Roberto Mallone; Anne-Kristin Heninger; Elsa M. Laughlin; Sharon A. Kochik; Ben Falk; William W. Kwok; Carla Greenbaum; Gerald T. Nepom
View articletitled, GAD65-Specific CD4<sup>+</sup> T-Cells with High Antigen Avidity Are Prevalent in Peripheral Blood of Patients With Type 1 Diabetes
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Diabetes August 2004, Vol.53, 1987-1994. doi:https://doi.org/10.2337/diabetes.53.8.1987
Flt3-Ligand Treatment Prevents Diabetes in NOD Mice
Paula M. Chilton; Francine Rezzoug; Isabelle Fugier-Vivier; Leslie A. Weeter; Hong Xu; Yiming Huang; Mukunda B. Ray; Suzanne T. Ildstad
View articletitled, Flt3-Ligand Treatment Prevents Diabetes in NOD Mice
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Diabetes August 2004, Vol.53, 1995-2002. doi:https://doi.org/10.2337/diabetes.53.8.1995
Hyperresponsiveness, Resistance to B-Cell Receptor—Dependent Activation-Induced Cell Death, and Accumulation of Hyperactivated B-Cells in Islets Is Associated With the Onset of Insulitis but not Type 1 Diabetes
Shabbir Hussain; Konstantin V. Salojin; Terry L. Delovitch
View articletitled, Hyperresponsiveness, Resistance to B-Cell Receptor—Dependent Activation-Induced Cell Death, and Accumulation of Hyperactivated B-Cells in Islets Is Associated With the Onset of Insulitis but not Type 1 Diabetes
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Diabetes August 2004, Vol.53, 2003-2011. doi:https://doi.org/10.2337/diabetes.53.8.2003
Major Histocompatibility Complex Class I Shedding and Programmed Cell Death Stimulated Through the Proinflammatory P2X7 Receptor: A Candidate Susceptibility Gene for NOD Diabetes
James I. Elliott; Christopher F. Higgins
View articletitled, Major Histocompatibility Complex Class I Shedding and Programmed Cell Death Stimulated Through the Proinflammatory P2X<sub>7</sub> Receptor<span class="subtitle-colon">: </span><span class="subtitle">A Candidate Susceptibility Gene for NOD Diabetes</span>
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Diabetes August 2004, Vol.53, 2012-2017. doi:https://doi.org/10.2337/diabetes.53.8.2012

Islet Studies

Autocrine Regulation of Single Pancreatic β-Cell Survival
Víctor Navarro-Tableros; M. Carmen Sánchez-Soto; Santiago García; Marcia Hiriart
View articletitled, Autocrine Regulation of Single Pancreatic β-Cell Survival
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Diabetes August 2004, Vol.53, 2018-2023. doi:https://doi.org/10.2337/diabetes.53.8.2018
Inhibition of Activin Signaling Induces Pancreatic Epithelial Cell Expansion and Diminishes Terminal Differentiation of Pancreatic β-Cells
You-Qing Zhang; Mary Malo Cleary; Yingjie Si; Guoxun Liu; Yuzuru Eto; Marcie Kritzik; Sandrine Dabernat; Ayse G. Kayali; Nora Sarvetnick
View articletitled, Inhibition of Activin Signaling Induces Pancreatic Epithelial Cell Expansion and Diminishes Terminal Differentiation of Pancreatic β-Cells
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Diabetes August 2004, Vol.53, 2024-2033. doi:https://doi.org/10.2337/diabetes.53.8.2024
Extracellular Matrix Protects Pancreatic β-Cells Against Apoptosis: Role of Short- and Long-Term Signaling Pathways
Eva Hammar; Géraldine Parnaud; Domenico Bosco; Nadja Perriraz; Kathrin Maedler; Marc Donath; Dominique G. Rouiller; Philippe A. Halban
View articletitled, Extracellular Matrix Protects Pancreatic β-Cells Against Apoptosis<span class="subtitle-colon">: </span><span class="subtitle">Role of Short- and Long-Term Signaling Pathways</span>
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Diabetes August 2004, Vol.53, 2034-2041. doi:https://doi.org/10.2337/diabetes.53.8.2034
Prospective Isolation of Multipotent Pancreatic Progenitors Using Flow-Cytometric Cell Sorting
Atsushi Suzuki; Hiromitsu Nakauchi; Hideki Taniguchi
View articletitled, Prospective Isolation of Multipotent Pancreatic Progenitors Using Flow-Cytometric Cell Sorting
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Diabetes August 2004, Vol.53, 2143-2152. doi:https://doi.org/10.2337/diabetes.53.8.2143

Pathophysiology

Insulin Dose-Response Curves for Stimulation of Splanchnic Glucose Uptake and Suppression of Endogenous Glucose Production Differ in Nondiabetic Humans and Are Abnormal in People With Type 2 Diabetes
Rita Basu; Ananda Basu; C. Michael Johnson; W. Frederick Schwenk; Robert A. Rizza
View articletitled, Insulin Dose-Response Curves for Stimulation of Splanchnic Glucose Uptake and Suppression of Endogenous Glucose Production Differ in Nondiabetic Humans and Are Abnormal in People With Type 2 Diabetes
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Diabetes August 2004, Vol.53, 2042-2050. doi:https://doi.org/10.2337/diabetes.53.8.2042
Splanchnic Cortisol Production Occurs in Humans: Evidence for Conversion of Cortisone to Cortisol Via the 11-β Hydroxysteroid Dehydrogenase (11β-HSD) Type 1 Pathway
Rita Basu; Ravinder J. Singh; Ananda Basu; Elizabeth G. Chittilapilly; C. Michael Johnson; Gianna Toffolo; Claudio Cobelli; Robert A. Rizza
View articletitled, Splanchnic Cortisol Production Occurs in Humans<span class="subtitle-colon">: </span><span class="subtitle">Evidence for Conversion of Cortisone to Cortisol Via the 11-β Hydroxysteroid Dehydrogenase (11β-HSD) Type 1 Pathway</span>
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Diabetes August 2004, Vol.53, 2051-2059. doi:https://doi.org/10.2337/diabetes.53.8.2051
Interactions Between Endothelin and Nitric Oxide in the Regulation of Vascular Tone in Obesity and Diabetes
Kieren J. Mather; Amale Lteif; Helmut O. Steinberg; Alain D. Baron
View articletitled, Interactions Between Endothelin and Nitric Oxide in the Regulation of Vascular Tone in Obesity and Diabetes
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Diabetes August 2004, Vol.53, 2060-2066. doi:https://doi.org/10.2337/diabetes.53.8.2060
Partial Gene Deletion of Endothelial Nitric Oxide Synthase Predisposes to Exaggerated High-Fat Diet—Induced Insulin Resistance and Arterial Hypertension
Stéphane Cook; Olivier Hugli; Marc Egli; Barbara Ménard; Sébastien Thalmann; Claudio Sartori; Christophe Perrin; Pascal Nicod; Bernard Thorens; Peter Vollenweider; Urs Scherrer; Rémy Burcelin
View articletitled, Partial Gene Deletion of Endothelial Nitric Oxide Synthase Predisposes to Exaggerated High-Fat Diet—Induced Insulin Resistance and Arterial Hypertension
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Diabetes August 2004, Vol.53, 2067-2072. doi:https://doi.org/10.2337/diabetes.53.8.2067
Vasomotor Responses to Hypoxia in Type 2 Diabetes
Cara J. Weisbrod; Peter R. Eastwood; Gerard O’Driscoll; Jennifer H. Walsh; Matthew Best; John R. Halliwill; Daniel J. Green
View articletitled, Vasomotor Responses to Hypoxia in Type 2 Diabetes
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Diabetes August 2004, Vol.53, 2073-2078. doi:https://doi.org/10.2337/diabetes.53.8.2073
Proinflammatory Cytokines, Markers of Cardiovascular Risks, Oxidative Stress, and Lipid Peroxidation in Patients With Hyperglycemic Crises
Frankie B. Stentz; Guillermo E. Umpierrez; Ruben Cuervo; Abbas E. Kitabchi
View articletitled, Proinflammatory Cytokines, Markers of Cardiovascular Risks, Oxidative Stress, and Lipid Peroxidation in Patients With Hyperglycemic Crises
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Diabetes August 2004, Vol.53, 2079-2086. doi:https://doi.org/10.2337/diabetes.53.8.2079
Intra-Abdominal Fat Is a Major Determinant of the National Cholesterol Education Program Adult Treatment Panel III Criteria for the Metabolic Syndrome
Darcy B. Carr; Kristina M. Utzschneider; Rebecca L. Hull; Keiichi Kodama; Barbara M. Retzlaff; John D. Brunzell; Jane B. Shofer; Brian E. Fish; Robert H. Knopp; Steven E. Kahn
View articletitled, Intra-Abdominal Fat Is a Major Determinant of the National Cholesterol Education Program Adult Treatment Panel III Criteria for the Metabolic Syndrome
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Diabetes August 2004, Vol.53, 2087-2094. doi:https://doi.org/10.2337/diabetes.53.8.2087
Impaired Glucose Tolerance, but not Impaired Fasting Glucose, Is Associated With Increased Levels of Coronary Heart Disease Risk Factors: Results From the Baltimore Longitudinal Study on Aging
Deirdre R. Blake; James B. Meigs; Denis C. Muller; Samer S. Najjar; Reubin Andres; David M. Nathan
View articletitled, Impaired Glucose Tolerance, but not Impaired Fasting Glucose, Is Associated With Increased Levels of Coronary Heart Disease Risk Factors<span class="subtitle-colon">: </span><span class="subtitle">Results From the Baltimore Longitudinal Study on Aging</span>
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Diabetes August 2004, Vol.53, 2095-2100. doi:https://doi.org/10.2337/diabetes.53.8.2095

Complication

Diminished Loss of Proteoglycans and Lack of Albuminuria in Protein Kinase C-α—Deficient Diabetic Mice
Jan Menne; Joon-Keun Park; Martin Boehne; Marlies Elger; Carsten Lindschau; Torsten Kirsch; Matthias Meier; Faikah Gueler; Annette Fiebeler; Ferdinand H. Bahlmann; Michael Leitges; Hermann Haller
View articletitled, Diminished Loss of Proteoglycans and Lack of Albuminuria in Protein Kinase C-α—Deficient Diabetic Mice
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Diabetes August 2004, Vol.53, 2101-2109. doi:https://doi.org/10.2337/diabetes.53.8.2101
Oxidative Stress Affects Synaptosomal γ-Aminobutyric Acid and Glutamate Transport in Diabetic Rats: The Role of Insulin
Ana I. Duarte; Maria S. Santos; Raquel Seiça; Catarina R. Oliveira
View articletitled, Oxidative Stress Affects Synaptosomal γ-Aminobutyric Acid and Glutamate Transport in Diabetic Rats<span class="subtitle-colon">: </span><span class="subtitle">The Role of Insulin</span>
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Diabetes August 2004, Vol.53, 2110-2116. doi:https://doi.org/10.2337/diabetes.53.8.2110
Surface Expression of Collagen Receptor Fc Receptor-γ/Glycoprotein VI Is Enhanced on Platelets in Type 2 Diabetes and Mediates Release of CD40 Ligand and Activation of Endothelial Cells
Natalia Cabeza; Zhongyan Li; Christian Schulz; Elisabeth Kremmer; Steffen Massberg; Andreas Bültmann; Meinrad Gawaz
View articletitled, Surface Expression of Collagen Receptor Fc Receptor-γ/Glycoprotein VI Is Enhanced on Platelets in Type 2 Diabetes and Mediates Release of CD40 Ligand and Activation of Endothelial Cells
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Diabetes August 2004, Vol.53, 2117-2121. doi:https://doi.org/10.2337/diabetes.53.8.2117

Brief Genetics Report

Polymorphic Variations in the Neurogenic Differentiation-1, Neurogenin-3, and Hepatocyte Nuclear Factor-1α Genes Contribute to Glucose Intolerance in a South Indian Population
Alan E. Jackson; Paul G. Cassell; Bernard V. North; Shanti Vijayaraghavan; Susan V. Gelding; Ambady Ramachandran; Chamukuttan Snehalatha; Graham A. Hitman
View articletitled, Polymorphic Variations in the Neurogenic Differentiation-1, Neurogenin-3, and Hepatocyte Nuclear Factor-1α Genes Contribute to Glucose Intolerance in a South Indian Population
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Diabetes August 2004, Vol.53, 2122-2125. doi:https://doi.org/10.2337/diabetes.53.8.2122
Variation at the Insulin Gene VNTR (Variable Number Tandem Repeat) Polymorphism and Early Growth : Studies in a Large Finnish Birth Cohort
Amanda J. Bennett; Ulla Sovio; Aimo Ruokonen; Hannu Martikainen; Anneli Pouta; Saara Taponen; Anna-Liisa Hartikainen; Vanessa J. King; Paul Elliott; Marjo-Riitta Järvelin; Mark I. McCarthy
View articletitled, Variation at the Insulin Gene VNTR (Variable Number Tandem Repeat) Polymorphism and Early Growth <span class="subtitle-colon">: </span><span class="subtitle">Studies in a Large Finnish Birth Cohort</span>
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Diabetes August 2004, Vol.53, 2126-2131. doi:https://doi.org/10.2337/diabetes.53.8.2126
Adiponectin Receptor 1 Gene (ADIPOR1) as a Candidate for Type 2 Diabetes and Insulin Resistance
Hua Wang; Hailing Zhang; Yiwen Jia; Zhengxian Zhang; Rebekah Craig; Xiaoqin Wang; Steven C. Elbein
View articletitled, Adiponectin Receptor 1 Gene (<em>ADIPOR1</em>) as a Candidate for Type 2 Diabetes and Insulin Resistance
Supplementary data
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Diabetes August 2004, Vol.53, 2132-2136. doi:https://doi.org/10.2337/diabetes.53.8.2132
Quantitative Trait Loci Near the Insulin-Degrading Enzyme (IDE) Gene Contribute to Variation in Plasma Insulin Levels
Harvest F. Gu; Suad Efendic; Sofia Nordman; Claes-Göran Östenson; Kerstin Brismar; Anthony J. Brookes; Jonathan A. Prince
View articletitled, Quantitative Trait Loci Near the Insulin-Degrading Enzyme (<em>IDE</em>) Gene Contribute to Variation in Plasma Insulin Levels
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Diabetes August 2004, Vol.53, 2137-2142. doi:https://doi.org/10.2337/diabetes.53.8.2137
SREBF-1 Gene Polymorphisms Are Associated With Obesity and Type 2 Diabetes in French Obese and Diabetic Cohorts
Delphine Eberlé; Karine Clément; David Meyre; Mourad Sahbatou; Martine Vaxillaire; Annie Le Gall; Pascal Ferré; Arnaud Basdevant; Philippe Froguel; Fabienne Foufelle
View articletitled, SREBF-1 Gene Polymorphisms Are Associated With Obesity and Type 2 Diabetes in French Obese and Diabetic Cohorts
Supplementary data
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Diabetes August 2004, Vol.53, 2153-2157. doi:https://doi.org/10.2337/diabetes.53.8.2153
DPB1 Alleles Are Associated With Type 1 Diabetes Susceptibility in Multiple Ethnic Groups
Thomas D. Cruz; Ana M. Valdes; Alma Santiago; Teresa Frazer de Llado; Leslie J. Raffel; Adina Zeidler; Jerome I. Rotter; Henry A. Erlich; Marian Rewers; Teodorica Bugawan; Janelle A. Noble
View articletitled, DPB1 Alleles Are Associated With Type 1 Diabetes Susceptibility in Multiple Ethnic Groups
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Diabetes August 2004, Vol.53, 2158-2163. doi:https://doi.org/10.2337/diabetes.53.8.2158
Severe Persistent Hyperinsulinemic Hypoglycemia due to a De Novo Glucokinase Mutation
Antonio L. Cuesta-Muñoz; Hanna Huopio; Timo Otonkoski; Juan M. Gomez-Zumaquero; Kirsti Näntö-Salonen; Jacques Rahier; Soledad López-Enriquez; Maria A. García-Gimeno; Pascual Sanz; Federico C. Soriguer; Markku Laakso
View articletitled, Severe Persistent Hyperinsulinemic Hypoglycemia due to a De Novo Glucokinase Mutation
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Diabetes August 2004, Vol.53, 2164-2168. doi:https://doi.org/10.2337/diabetes.53.8.2164

Pharmacology & Therapeutics

Effects of Rosiglitazone and Metformin on Liver Fat Content, Hepatic Insulin Resistance, Insulin Clearance, and Gene Expression in Adipose Tissue in Patients With Type 2 Diabetes
Mirja Tiikkainen; Anna-Maija Häkkinen; Elena Korsheninnikova; Tuulikki Nyman; Sari Mäkimattila; Hannele Yki-Järvinen
View articletitled, Effects of Rosiglitazone and Metformin on Liver Fat Content, Hepatic Insulin Resistance, Insulin Clearance, and Gene Expression in Adipose Tissue in Patients With Type 2 Diabetes
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Diabetes August 2004, Vol.53, 2169-2176. doi:https://doi.org/10.2337/diabetes.53.8.2169

Errata

Errata
View articletitled, Errata
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Diabetes August 2004, Vol.53, 2177. doi:https://doi.org/10.2337/diabetes.53.8.2177
Errata
View articletitled, Errata
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Diabetes August 2004, Vol.53, 2177. doi:https://doi.org/10.2337/diabetes.53.8.2177-a
Système International (SI) Units Table
Management of Latent Autoimmune Diabetes in Adults: A Consensus Statement From an International Expert Panel
713-P: Is There a Correct Time to Measure Fasting Blood Sugar in Persons with Type 2 Diabetes Melitus?
300-OR: Beneficial Effect of the Combination Therapy of Cagrilintide, a Dual Amylin/Calcitonin Agonist, and Tirzepatide, a Dual GLP-1/GIP Agonist, on Body Weight Loss in Obese Rats
Elevated First-Trimester Neutrophil Count Is Closely Associated With the Development of Maternal Gestational Diabetes Mellitus and Adverse Pregnancy Outcomes
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