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Metabolism

Interaction of Glucokinase With the Liver Regulatory Protein Is Conferred by Leucine-Asparagine Motifs of the Enzyme

Simone Baltrusch; Flavio Francini; Sigurd Lenzen; Markus Tiedge

Abstract

View articletitled, Interaction of Glucokinase With the Liver Regulatory Protein Is Conferred by Leucine-Asparagine Motifs of the Enzyme

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Topics: glucokinase , leucine , asparagine

Diabetes October 2005, Vol.54, 2829-2837. doi:https://doi.org/10.2337/diabetes.54.10.2829

Obesity Studies

Activation of the Peripheral Endocannabinoid System in Human Obesity

Stefan Engeli; Jana Böhnke; Mareike Feldpausch; Kerstin Gorzelniak; Jürgen Janke; Sándor Bátkai; Pál Pacher; Judy Harvey-White; Friedrich C. Luft; Arya M. Sharma; Jens Jordan

Abstracts

View articletitled, Activation of the Peripheral Endocannabinoid System in Human Obesity

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Topics: endocannabinoids , obesity , weight reduction , adipose tissue , adipocytes

Diabetes October 2005, Vol.54, 2838-2843. doi:https://doi.org/10.2337/diabetes.54.10.2838

Plasma Visfatin Concentrations and Fat Depot–Specific mRNA Expression in Humans

Janin Berndt; Nora Klöting; Susan Kralisch; Peter Kovacs; Mathias Fasshauer; Michael R. Schön; Michael Stumvoll; Matthias Blüher

Abstract

View articletitled, Plasma Visfatin Concentrations and Fat Depot–Specific mRNA Expression in Humans

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Topics: glucose , plasma , rna, messenger , visceral fat , gene expression

Diabetes October 2005, Vol.54, 2911-2916. doi:https://doi.org/10.2337/diabetes.54.10.2911

Islet Studies

Attenuated Wnt Signaling Perturbs Pancreatic Growth but Not Pancreatic Function

Stella Papadopoulou; Helena Edlund

Abstract

View articletitled, Attenuated Wnt Signaling Perturbs Pancreatic Growth but Not Pancreatic Function

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Topics: insulin , mice , pancreas , signal transduction , glucose

Diabetes October 2005, Vol.54, 2844-2851. doi:https://doi.org/10.2337/diabetes.54.10.2844

Membrane Phosphoinositides Control Insulin Secretion Through Their Effects on ATP-Sensitive K⁺ Channel Activity

Chia-Wei Lin; Feifei Yan; Satoko Shimamura; Sebastian Barg; Show-Ling Shyng

Abstracts

View articletitled, Membrane Phosphoinositides Control Insulin Secretion Through Their Effects on ATP-Sensitive K+ Channel Activity

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Topics: depolarization , glucose , insulin secretion , phosphatidylinositols , tissue membrane

Diabetes October 2005, Vol.54, 2852-2858. doi:https://doi.org/10.2337/diabetes.54.10.2852

BETA2/NeuroD Protein Can Be Transduced Into Cells Due to an Arginine- and Lysine-Rich Sequence

Hirofumi Noguchi; Susan Bonner-Weir; Fan-Yan Wei; Masayuki Matsushita; Shinichi Matsumoto

Abstract

View articletitled, BETA2/NeuroD Protein Can Be Transduced Into Cells Due to an Arginine- and Lysine-Rich Sequence

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Topics: arginine , dynamin , endocrine pancreas , endocytosis , fluorescein

Diabetes October 2005, Vol.54, 2859-2866. doi:https://doi.org/10.2337/diabetes.54.10.2859

Signals From the Embryonic Mouse Pancreas Induce Differentiation of Human Embryonic Stem Cells Into Insulin-Producing β-Cell–Like Cells

Gabriella K.C. Brolén; Nico Heins; Josefina Edsbagge; Henrik Semb

Abstract

View articletitled, Signals From the Embryonic Mouse Pancreas Induce Differentiation of Human Embryonic Stem Cells Into Insulin-Producing β-Cell–Like Cells

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Topics: embryo , insulin , mice , pancreas , c-peptide

Diabetes October 2005, Vol.54, 2867-2874. doi:https://doi.org/10.2337/diabetes.54.10.2867

Increased Fatty Acid Desaturation and Enhanced Expression of Stearoyl Coenzyme A Desaturase Protects Pancreatic β-Cells from Lipoapoptosis

Anna K. Busch; Ebru Gurisik; Damien V. Cordery; Michelle Sudlow; Gareth S. Denyer; D. Ross Laybutt; William E. Hughes; Trevor J. Biden

Abstract

View articletitled, Increased Fatty Acid Desaturation and Enhanced Expression of Stearoyl Coenzyme A Desaturase Protects Pancreatic β-Cells from Lipoapoptosis

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Topics: cholesterol esters , fatty acids , palmitates , desaturation of blood , lipids

Diabetes October 2005, Vol.54, 2917-2924. doi:https://doi.org/10.2337/diabetes.54.10.2917

ATP-Sensitive K⁺ Channel Signaling in Glucokinase-Deficient Diabetes

Maria S. Remedi; Joseph C. Koster; Brian L. Patton; Colin G. Nichols

Abstract

View articletitled, ATP-Sensitive K+ Channel Signaling in Glucokinase-Deficient Diabetes

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Topics: glucokinase , glucose , insulin , insulin secretion , mice

Diabetes October 2005, Vol.54, 2925-2931. doi:https://doi.org/10.2337/diabetes.54.10.2925

Pathophysiology

Bone Formation Is Impaired in a Model of Type 1 Diabetes

Kathryn M. Thrailkill; Lichu Liu; Elizabeth C. Wahl; Robert C. Bunn; Daniel S. Perrien; Gael E. Cockrell; Robert A. Skinner; William R. Hogue; Adam A. Carver; John L. Fowlkes; James Aronson; Charles K. Lumpkin, Jr.

Abstract

View articletitled, Bone Formation Is Impaired in a Model of Type 1 Diabetes

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Topics: diabetes mellitus, type 1 , insulin , mice , mice, inbred nod , osteogenesis

Diabetes October 2005, Vol.54, 2875-2881. doi:https://doi.org/10.2337/diabetes.54.10.2875

Elevated Levels of Interleukin-18 Predict the Development of Type 2 Diabetes: Results From the MONICA/KORA Augsburg Study, 1984–2002

Barbara Thorand; Hubert Kolb; Jens Baumert; Wolfgang Koenig; Lloyd Chambless; Christa Meisinger; Thomas Illig; Stephan Martin; Christian Herder

Abstract

View articletitled, Elevated Levels of Interleukin-18 Predict the Development of Type 2 Diabetes: Results From the MONICA/KORA Augsburg Study, 1984–2002

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Topics: c-reactive protein , diabetes mellitus, type 2 , interleukin-18 , interleukin-6 , family history

Diabetes October 2005, Vol.54, 2932-2938. doi:https://doi.org/10.2337/diabetes.54.10.2932

Tumor Necrosis Factor-α Induces Skeletal Muscle Insulin Resistance in Healthy Human Subjects via Inhibition of Akt Substrate 160 Phosphorylation

Peter Plomgaard; Karim Bouzakri; Rikke Krogh-Madsen; Bettina Mittendorfer; Juleen R. Zierath; Bente K. Pedersen

Abstracts

View articletitled, Tumor Necrosis Factor-α Induces Skeletal Muscle Insulin Resistance in Healthy Human Subjects via Inhibition of Akt Substrate 160 Phosphorylation

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Topics: glucose , infusion procedures , insulin , insulin resistance , phosphorylation

Diabetes October 2005, Vol.54, 2939-2945. doi:https://doi.org/10.2337/diabetes.54.10.2939

Serum Glucagon Counterregulatory Hormonal Response to Hypoglycemia Is Blunted in Congenital Hyperinsulinism

Khalid Hussain; Joseph Bryan; Henrick T. Christesen; Klaus Brusgaard; Lydia Aguilar-Bryan

Abstract

View articletitled, Serum Glucagon Counterregulatory Hormonal Response to Hypoglycemia Is Blunted in Congenital Hyperinsulinism

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Topics: congenital hyperinsulinism , glucagon , hypoglycemia , epinephrine , norepinephrine

Diabetes October 2005, Vol.54, 2946-2951. doi:https://doi.org/10.2337/diabetes.54.10.2946

Complications

Gene Delivery of Tim44 Reduces Mitochondrial Superoxide Production and Ameliorates Neointimal Proliferation of Injured Carotid Artery in Diabetic Rats

Takashi Matsuoka; Jun Wada; Izumi Hashimoto; Yanling Zhang; Jun Eguchi; Norio Ogawa; Kenichi Shikata; Yashpal S. Kanwar; Hirofumi Makino

Abstract

View articletitled, Gene Delivery of Tim44 Reduces Mitochondrial Superoxide Production and Ameliorates Neointimal Proliferation of Injured Carotid Artery in Diabetic Rats

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Topics: balloon dilatation , carotid arteries , genes , glucose , mitochondria

Diabetes October 2005, Vol.54, 2882-2890. doi:https://doi.org/10.2337/diabetes.54.10.2882

Antiangiogenic Endostatin Peptide Ameliorates Renal Alterations in the Early Stage of a Type 1 Diabetic Nephropathy Model

Kunihiro Ichinose; Yohei Maeshima; Yoshihiko Yamamoto; Hiroyuki Kitayama; Yuki Takazawa; Kumiko Hirokoshi; Hitoshi Sugiyama; Yasushi Yamasaki; Katsumi Eguchi; Hirofumi Makino

Abstracts

View articletitled, Antiangiogenic Endostatin Peptide Ameliorates Renal Alterations in the Early Stage of a Type 1 Diabetic Nephropathy Model

Supplementary data

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Topics: diabetic nephropathy , endostatins , kidney , kidney glomerulus , mice

Diabetes October 2005, Vol.54, 2891-2903. doi:https://doi.org/10.2337/diabetes.54.10.2891

The Pathogenesis of Staphylococcus aureus Infection in the Diabetic NOD Mouse

Jeremy Rich; Jean C. Lee

Abstract

View articletitled, The Pathogenesis of Staphylococcus aureus Infection in the Diabetic NOD Mouse

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Topics: infections , leukocytes , mice , mice, inbred nod , cytokine

Diabetes October 2005, Vol.54, 2904-2910. doi:https://doi.org/10.2337/diabetes.54.10.2904

Mechanism of Perturbation of Integrin-Mediated Cell-Matrix Interactions by Reactive Carbonyl Compounds and Its Implication for Pathogenesis of Diabetic Nephropathy

Vadim K. Pedchenko; Sergei V. Chetyrkin; Peale Chuang; Amy-Joan L. Ham; Moin A. Saleem; Peter W. Mathieson; Billy G. Hudson; Paul A. Voziyan

Abstract

View articletitled, Mechanism of Perturbation of Integrin-Mediated Cell-Matrix Interactions by Reactive Carbonyl Compounds and Its Implication for Pathogenesis of Diabetic Nephropathy

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Topics: arginine , cell adhesion , collagen type iv , glucose , integrins

Diabetes October 2005, Vol.54, 2952-2960. doi:https://doi.org/10.2337/diabetes.54.10.2952

Modulation of the Renal Response to ACE Inhibition by ACE Insertion/Deletion Polymorphism During Hyperglycemia in Normotensive, Normoalbuminuric Type 1 Diabetic Patients

Laurent Weekers; Béatrice Bouhanick; Samy Hadjadj; Yves Gallois; Ronen Roussel; Franck Pean; Amos Ankotche; Gilles Chatellier; François Alhenc-Gelas; Pierre J. Lefebvre; Michel Marre

Abstracts

View articletitled, Modulation of the Renal Response to ACE Inhibition by ACE Insertion/Deletion Polymorphism During Hyperglycemia in Normotensive, Normoalbuminuric Type 1 Diabetic Patients

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Topics: genotype , hyperglycemia , kidney , polymorphism , ramipril

Diabetes October 2005, Vol.54, 2961-2967. doi:https://doi.org/10.2337/diabetes.54.10.2961

Effects of Insulin on Methionine and Homocysteine Kinetics in Type 2 Diabetes With Nephropathy

Paolo Tessari; Anna Coracina; Edward Kiwanuka; Monica Vedovato; Monica Vettore; Anna Valerio; Michela Zaramella; Giacomo Garibotto

Abstract

View articletitled, Effects of Insulin on Methionine and Homocysteine Kinetics in Type 2 Diabetes With Nephropathy

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Topics: diabetes mellitus, type 2 , homocysteine , insulin , methionine , kidney diseases

Diabetes October 2005, Vol.54, 2968-2976. doi:https://doi.org/10.2337/diabetes.54.10.2968

Statins Ameliorate Endothelial Barrier Permeability Changes in the Cerebral Tissue of Streptozotocin-Induced Diabetic Rats

Arshag D. Mooradian; Michael J. Haas; Oksana Batejko; Meri Hovsepyan; Stephen S. Feman

Abstract

View articletitled, Statins Ameliorate Endothelial Barrier Permeability Changes in the Cerebral Tissue of Streptozotocin-Induced Diabetic Rats

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Topics: brain , dextrans , endothelium , mevalonate , permeability

Diabetes October 2005, Vol.54, 2977-2982. doi:https://doi.org/10.2337/diabetes.54.10.2977

Factors Associated With Frequent Remission of Microalbuminuria in Patients With Type 2 Diabetes

Shin-ichi Araki; Masakazu Haneda; Toshiro Sugimoto; Motohide Isono; Keiji Isshiki; Atsunori Kashiwagi; Daisuke Koya

Abstract

View articletitled, Factors Associated With Frequent Remission of Microalbuminuria in Patients With Type 2 Diabetes

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Topics: diabetes mellitus, type 2 , disease remission , microalbuminuria , urinary tract , diabetic nephropathy

Diabetes October 2005, Vol.54, 2983-2987. doi:https://doi.org/10.2337/diabetes.54.10.2983

Pharmacology & Therapeutics

Dipeptidyl Peptidase IV Inhibition for the Treatment of Type 2 Diabetes: Potential Importance of Selectivity Over Dipeptidyl Peptidases 8 and 9

Abstracts

View articletitled, Dipeptidyl Peptidase IV Inhibition for the Treatment of Type 2 Diabetes: Potential Importance of Selectivity Over Dipeptidyl Peptidases 8 and 9

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Topics: allopurinol , dipeptidyl peptidases , toxic effect , dog, domestic , rats

Diabetes October 2005, Vol.54, 2988-2994. doi:https://doi.org/10.2337/diabetes.54.10.2988

Genetics

Type 1 Diabetes: Evidence for Susceptibility Loci from Four Genome-Wide Linkage Scans in 1,435 Multiplex Families

Patrick Concannon; Henry A. Erlich; Cecile Julier; Grant Morahan; Jørn Nerup; Flemming Pociot; John A. Todd; Stephen S. Rich; the Type 1 Diabetes Genetics Consortium

Abstracts

View articletitled, Type 1 Diabetes: Evidence for Susceptibility Loci from Four Genome-Wide Linkage Scans in 1,435 Multiplex Families

Supplementary data

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Topics: diabetes mellitus, type 1 , genome , human leukocyte antigens , chromosomes

Diabetes October 2005, Vol.54, 2995-3001. doi:https://doi.org/10.2337/diabetes.54.10.2995

Elevated Levels of Mannose-Binding Lectin at Clinical Manifestation of Type 1 Diabetes in Juveniles

Lee H. Bouwman; Peter Eerligh; Onno T. Terpstra; Mohamed R. Daha; Peter de Knijff; Bart E.P.B. Ballieux; G. Jan Bruining; Arno R. van der Slik; Anja Roos; Bart O. Roep

Abstracts

View articletitled, Elevated Levels of Mannose-Binding Lectin at Clinical Manifestation of Type 1 Diabetes in Juveniles

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Topics: autoantibodies , child , c-reactive protein , diabetes mellitus, type 1 , fructosamine

Diabetes October 2005, Vol.54, 3002-3006. doi:https://doi.org/10.2337/diabetes.54.10.3002

Analysis of Quantitative Lipid Traits in the Genetics of NIDDM (GENNID) Study

Alka Malhotra; Johanna K. Wolford; the American Diabetes Association GENNID Study Group

Abstracts

View articletitled, Analysis of Quantitative Lipid Traits in the Genetics of NIDDM (GENNID) Study

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Topics: diabetes mellitus, type 2 , high density lipoproteins , lipids , loudness discomfort level , low-density lipoproteins

Diabetes October 2005, Vol.54, 3007-3014. doi:https://doi.org/10.2337/diabetes.54.10.3007

Genetic and Nongenetic Regulation of CAPN10 mRNA Expression in Skeletal Muscle

Emma Carlsson; Pernille Poulsen; Heidi Storgaard; Peter Almgren; Charlotte Ling; Christine Bjørn Jensen; Sten Madsbad; Leif Groop; Allan Vaag; Martin Ridderstråle

Abstracts

View articletitled, Genetic and Nongenetic Regulation of CAPN10 mRNA Expression in Skeletal Muscle

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Topics: calpain 10 , insulin , intravenous fat emulsions , rna, messenger , skeletal muscles

Diabetes October 2005, Vol.54, 3015-3020. doi:https://doi.org/10.2337/diabetes.54.10.3015

Brief Genetics Reports

The K121Q Polymorphism of the ENPP1/PC-1 Gene Is Associated With Insulin Resistance/Atherogenic Phenotypes, Including Earlier Onset of Type 2 Diabetes and Myocardial Infarction

Simonetta Bacci; Ornella Ludovico; Sabrina Prudente; Yuan-Yuan Zhang; Rosa Di Paola; Davide Mangiacotti; Anna Rauseo; David Nolan; Jill Duffy; Grazia Fini; Lucia Salvemini; Cesare Amico; Carlo Vigna; Fabio Pellegrini; Claudia Menzaghi; Alessandro Doria; Vincenzo Trischitta

Abstracts

View articletitled, The K121Q Polymorphism of the ENPP1/PC-1 Gene Is Associated With Insulin Resistance/Atherogenic Phenotypes, Including Earlier Onset of Type 2 Diabetes and Myocardial Infarction

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Topics: diabetes mellitus, type 2 , genes , insulin resistance , myocardial infarction , phenotype

Diabetes October 2005, Vol.54, 3021-3025. doi:https://doi.org/10.2337/diabetes.54.10.3021

A −30G>A Polymorphism of the β-Cell–Specific Glucokinase Promoter Associates With Hyperglycemia in the General Population of Whites

Christian S. Rose; Jakob Ek; Søren A. Urhammer; Charlotte Glümer; Knut Borch-Johnsen; Torben Jørgensen; Oluf Pedersen; Torben Hansen

Abstract

View articletitled, A −30G>A Polymorphism of the β-Cell–Specific Glucokinase Promoter Associates With Hyperglycemia in the General Population of Whites

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Topics: diabetes mellitus, type 2 , fasting , glucokinase , glucose , hyperglycemia

Diabetes October 2005, Vol.54, 3026-3031. doi:https://doi.org/10.2337/diabetes.54.10.3026

The CIDEA Gene V115F Polymorphism Is Associated With Obesity in Swedish Subjects

Ingrid Dahlman; Maria Kaaman; Hong Jiao; Juha Kere; Markku Laakso; Peter Arner

Abstract

View articletitled, The CIDEA Gene V115F Polymorphism Is Associated With Obesity in Swedish Subjects

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Topics: genes , obesity , polymorphism , single nucleotide polymorphism

Diabetes October 2005, Vol.54, 3032-3034. doi:https://doi.org/10.2337/diabetes.54.10.3032

Variants in Hepatocyte Nuclear Factor 4α Are Modestly Associated With Type 2 Diabetes in Pima Indians

Yunhua Li Muller; Aniello M. Infante; Robert L. Hanson; Latisha Love-Gregory; William Knowler; Clifton Bogardus; Leslie J. Baier

Abstract

View articletitled, Variants in Hepatocyte Nuclear Factor 4α Are Modestly Associated With Type 2 Diabetes in Pima Indians

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Topics: diabetes mellitus, type 2 , single nucleotide polymorphism , hepatocytes

Diabetes October 2005, Vol.54, 3035-3039. doi:https://doi.org/10.2337/diabetes.54.10.3035

Common Polymorphisms in the USF1 Gene Are Not Associated With Type 2 Diabetes in French Caucasians

Fernando Gibson; Serge Hercberg; Philippe Froguel

Abstracts

View articletitled, Common Polymorphisms in the USF1 Gene Are Not Associated With Type 2 Diabetes in French Caucasians

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Topics: diabetes mellitus, type 2 , genes , hyperlipidemia, familial combined , single nucleotide polymorphism , blood glucose normal

Diabetes October 2005, Vol.54, 3040-3042. doi:https://doi.org/10.2337/diabetes.54.10.3040

Association Between Peroxisome Proliferator–Activated Receptor γ Haplotypes and the Metabolic Syndrome in French Men and Women

Aline Meirhaeghe; Dominique Cottel; Philippe Amouyel; Jean Dallongeville

Abstract

View articletitled, Association Between Peroxisome Proliferator–Activated Receptor γ Haplotypes and the Metabolic Syndrome in French Men and Women

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Topics: haplotypes , metabolic syndrome x , peroxisome proliferator-activated receptors , polymorphism , single nucleotide polymorphism

Diabetes October 2005, Vol.54, 3043-3048. doi:https://doi.org/10.2337/diabetes.54.10.3043

Association of Melanin-Concentrating Hormone Receptor 1 5′ Polymorphism With Early-Onset Extreme Obesity

Christopher G. Bell; David Meyre; Chantal Samson; Cliona Boyle; Cécile Lecoeur; Maïte Tauber; Béatrice Jouret; Delphine Jaquet; Claire Levy-Marchal; Marie Aline Charles; Jacques Weill; Fernando Gibson; Charles A. Mein; Philippe Froguel; Andrew J. Walley

Abstract

View articletitled, Association of Melanin-Concentrating Hormone Receptor 1 5′ Polymorphism With Early-Onset Extreme Obesity

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Topics: child , dna , genes , hormone receptors , melanins

Diabetes October 2005, Vol.54, 3049-3055. doi:https://doi.org/10.2337/diabetes.54.10.3049

Perspectives in Diabetes

Apical GLUT2 : A Major Pathway of Intestinal Sugar Absorption

George L. Kellett; Edith Brot-Laroche

Abstract

View articletitled, Apical GLUT2 : A Major Pathway of Intestinal Sugar Absorption

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Topics: diet , glucose , intestines , process of absorption , sugars

Diabetes October 2005, Vol.54, 3056-3062. doi:https://doi.org/10.2337/diabetes.54.10.3056

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