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Issues
December 2005
ISSN 0012-1797
EISSN 1939-327X
Signal Transduction
Peripheral Hyperinsulinemia Promotes Tau Phosphorylation In Vivo
Susanna Freude; Leona Plum; Jessika Schnitker; Uschi Leeser; Michael Udelhoven; Wilhelm Krone; Jens C. Bruning; Markus Schubert
Diabetes December 2005, Vol.54, 3343-3348. doi:https://doi.org/10.2337/diabetes.54.12.3343
Skeletal Muscle Insulin Signaling Defects Downstream of Phosphatidylinositol 3-Kinase at the Level of Akt Are Associated With Impaired Nonoxidative Glucose Disposal in HIV Lipodystrophy
Steen B. Haugaard; Ove Andersen; Sten Madsbad; Christian Frøsig; Johan Iversen; Jens Ole Nielsen; Jørgen F.P. Wojtaszewski
Diabetes December 2005, Vol.54, 3474-3483. doi:https://doi.org/10.2337/diabetes.54.12.3474
Changes in Exercise-Induced Gene Expression in 5′-AMP–Activated Protein Kinase γ3–Null and γ3 R225Q Transgenic Mice
Brian R. Barnes; Yun Chau Long; Tatiana L. Steiler; Ying Leng; Dana Galuska; Jørgen F.P. Wojtaszewski; Leif Andersson; Juleen R. Zierath
Diabetes December 2005, Vol.54, 3484-3489. doi:https://doi.org/10.2337/diabetes.54.12.3484
The Lack of β-Adrenoceptors Results in Enhanced Insulin Sensitivity in Mice Exhibiting Increased Adiposity and Glucose Intolerance
Diabetes December 2005, Vol.54, 3490-3495. doi:https://doi.org/10.2337/diabetes.54.12.3490
Plasma Free Fatty Acids and Peroxisome Proliferator–Activated Receptor α in the Control of Myocardial Uncoupling Protein Levels
Diabetes December 2005, Vol.54, 3496-3502. doi:https://doi.org/10.2337/diabetes.54.12.3496
Obesity Studies
Expression of Inducible 6-Phosphofructo-2-Kinase/Fructose-2,6-Bisphosphatase/PFKFB3 Isoforms in Adipocytes and Their Potential Role in Glycolytic Regulation
Toshiya Atsumi; Taro Nishio; Hirokatsu Niwa; Jun Takeuchi; Hidenori Bando; Chikara Shimizu; Narihito Yoshioka; Richard Bucala; Takao Koike
Diabetes December 2005, Vol.54, 3349-3357. doi:https://doi.org/10.2337/diabetes.54.12.3349
Peroxisome Proliferator–Activated Receptor (PPAR)α Activation Increases Adiponectin Receptors and Reduces Obesity-Related Inflammation in Adipose Tissue: Comparison of Activation of PPARα, PPARγ, and Their Combination
Atsushi Tsuchida; Toshimasa Yamauchi; Sato Takekawa; Yusuke Hada; Yusuke Ito; Toshiyuki Maki; Takashi Kadowaki
Diabetes December 2005, Vol.54, 3358-3370. doi:https://doi.org/10.2337/diabetes.54.12.3358
A Polygenic Model of the Metabolic Syndrome With Reduced Circulating and Intra-Adipose Glucocorticoid Action
Nicholas M. Morton; Valerie Densmore; Malgorzata Wamil; Lynne Ramage; Katherine Nichol; Lutz Bünger; Jonathan R. Seckl; Christopher J. Kenyon
Diabetes December 2005, Vol.54, 3371-3378. doi:https://doi.org/10.2337/diabetes.54.12.3371
Whole-body Insulin Resistance in the Absence of Obesity in FVB Mice With Overexpression of Dgat1 in Adipose Tissue
Diabetes December 2005, Vol.54, 3379-3386. doi:https://doi.org/10.2337/diabetes.54.12.3379
Decreased Fat Mass in Interleukin-1 Receptor Antagonist–Deficient Mice : Impact on Adipogenesis, Food Intake, and Energy Expenditure
Emmanuel Somm; Elvire Henrichot; Agnès Pernin; Cristiana E. Juge-Aubry; Patrick Muzzin; Jean-Michel Dayer; Martin J.H. Nicklin; Christoph A. Meier
Diabetes December 2005, Vol.54, 3503-3509. doi:https://doi.org/10.2337/diabetes.54.12.3503
Resistance to Diet-Induced Obesity in μ-Opioid Receptor–Deficient Mice : Evidence for a “Thrifty Gene”
Antoine Tabarin; Yolanda Diz-Chaves; Maria del Carmen Carmona; Bogdan Catargi; Eric P. Zorrilla; Amanda J. Roberts; Donald V. Coscina; Sophie Rousset; Anabelle Redonnet; Graham C. Parker; Koki Inoue; Daniel Ricquier; Luc Pénicaud; Brigitte L. Kieffer; Georges F. Koob
Diabetes December 2005, Vol.54, 3510-3516. doi:https://doi.org/10.2337/diabetes.54.12.3510
Immunology and Transplantation
Growth and Functional Maturation of β-Cells in Implants of Endocrine Cells Purified From Prenatal Porcine Pancreas
Marika Bogdani; Krista Suenens; Troels Bock; Miriam Pipeleers-Marichal; Peter In’t Veld; Daniel Pipeleers
Diabetes December 2005, Vol.54, 3387-3394. doi:https://doi.org/10.2337/diabetes.54.12.3387
On the Edge of Autoimmunity : T-Cell Stimulation by Steady-State Dendritic Cells Prevents Autoimmune Diabetes
Dunja Bruder; Astrid M. Westendorf; Wiebke Hansen; Silvia Prettin; Achim D. Gruber; Yingjie Qian; Harald von Boehmer; Karsten Mahnke; Jan Buer
Diabetes December 2005, Vol.54, 3395-3401. doi:https://doi.org/10.2337/diabetes.54.12.3395
Islet Studies
The HMG Box Transcription Factor Sox4 Contributes to the Development of the Endocrine Pancreas
Maria E. Wilson; Katherine Y. Yang; Anna Kalousova; Janet Lau; Yasuhiro Kosaka; Francis C. Lynn; Juehu Wang; Caroline Mrejen; Vasso Episkopou; Hans C. Clevers; Michael S. German
Diabetes December 2005, Vol.54, 3402-3409. doi:https://doi.org/10.2337/diabetes.54.12.3402
Inhibition of Preproinsulin Gene Expression by Leptin Induction of Suppressor of Cytokine Signaling 3 in Pancreatic β-Cells
Diabetes December 2005, Vol.54, 3410-3417. doi:https://doi.org/10.2337/diabetes.54.12.3410
Individual Mice Can Be Distinguished by the Period of Their Islet Calcium Oscillations : Is There an Intrinsic Islet Period That Is Imprinted In Vivo?
Craig S. Nunemaker; Min Zhang; David H. Wasserman; Owen P. McGuinness; Alvin C. Powers; Richard Bertram; Arthur Sherman; Leslie S. Satin
Diabetes December 2005, Vol.54, 3517-3522. doi:https://doi.org/10.2337/diabetes.54.12.3517
Rho Guanosine Diphosphate–Dissociation Inhibitor Plays a Negative Modulatory Role in Glucose-Stimulated Insulin Secretion
Diabetes December 2005, Vol.54, 3523-3529. doi:https://doi.org/10.2337/diabetes.54.12.3523
Complications
Aspirin at Low-Intermediate Concentrations Protects Retinal Vessels in Experimental Diabetic Retinopathy Through Non–Platelet-Mediated Effects
Diabetes December 2005, Vol.54, 3418-3426. doi:https://doi.org/10.2337/diabetes.54.12.3418
Glucose Transporters in Human Renal Proximal Tubular Cells Isolated From the Urine of Patients With Non–Insulin-Dependent Diabetes
Diabetes December 2005, Vol.54, 3427-3434. doi:https://doi.org/10.2337/diabetes.54.12.3427
Oxidative-Nitrosative Stress and Poly(ADP-Ribose) Polymerase (PARP) Activation in Experimental Diabetic Neuropathy: The Relation Is Revisited
Irina G. Obrosova; Viktor R. Drel; Pal Pacher; Olga Ilnytska; Zhong Q. Wang; Martin J. Stevens; Mark A. Yorek
Diabetes December 2005, Vol.54, 3435-3441. doi:https://doi.org/10.2337/diabetes.54.12.3435
Polymorphisms in igf-Binding Protein 1 Are Associated With Impaired Renal Function in Type 2 Diabetes
Richard H. Stephens; Patrick McElduff; Adrian H. Heald; John P. New; Jane Worthington; William E. Ollier; J. Martin Gibson
Diabetes December 2005, Vol.54, 3547-3553. doi:https://doi.org/10.2337/diabetes.54.12.3547
Plasma Cholesteryl Ester Transfer Is a Determinant of Intima-Media Thickness in Type 2 Diabetic and Nondiabetic Subjects : Role of cetp and Triglycerides
Rindert de Vries; Frank G. Perton; Geesje M. Dallinga-Thie; Arie M. van Roon; Bruce H.R. Wolffenbuttel; Arie van Tol; Robin P.F. Dullaart
Diabetes December 2005, Vol.54, 3554-3559. doi:https://doi.org/10.2337/diabetes.54.12.3554
Pharmacology and Therapeutics
Molecular Characterization of New Selective Peroxisome Proliferator–Activated Receptor γ Modulators With Angiotensin Receptor Blocking Activity
Michael Schupp; Markus Clemenz; Romain Gineste; Henning Witt; Jürgen Janke; Stephane Helleboid; Nathalie Hennuyer; Patricia Ruiz; Thomas Unger; Bart Staels; Ulrich Kintscher
Diabetes December 2005, Vol.54, 3442-3452. doi:https://doi.org/10.2337/diabetes.54.12.3442
Brief Genetics Reports
Localization of Idd11 Is Not Associated With Thymus and NKT Cell Abnormalities in NOD Mice
Thomas C. Brodnicki; Anne L. Fletcher; Daniel G. Pellicci; Stuart P. Berzins; Peter McClive; Fiona Quirk; Kylie E. Webster; Hamish S. Scott; Richard L. Boyd; Dale I. Godfrey; Grant Morahan
Diabetes December 2005, Vol.54, 3453-3457. doi:https://doi.org/10.2337/diabetes.54.12.3453
Patterns of Linkage Disequilibrium in the Type 2 Diabetes Gene Calpain-10
M. Geoffrey Hayes; Laura del Bosque-Plata; Takafumi Tsuchiya; Craig L. Hanis; Graeme I. Bell; Nancy J. Cox
Diabetes December 2005, Vol.54, 3573-3576. doi:https://doi.org/10.2337/diabetes.54.12.3573
Insulin Resistance Syndrome in Subjects With Mutated RING Finger Protein TRIM37
Diabetes December 2005, Vol.54, 3577-3581. doi:https://doi.org/10.2337/diabetes.54.12.3577
Genetic Heterogeneity in Association of the SUMO4 M55V Variant With Susceptibility to Type 1 Diabetes
Shinsuke Noso; Hiroshi Ikegami; Tomomi Fujisawa; Yumiko Kawabata; Katsuaki Asano; Yoshihisa Hiromine; Masako Tsurumaru; Shigetaka Sugihara; Inkyu Lee; Eiji Kawasaki; Takuya Awata; Toshio Ogihara
Diabetes December 2005, Vol.54, 3582-3586. doi:https://doi.org/10.2337/diabetes.54.12.3582
Single Nucleotide Polymorphisms in the Peroxisome Proliferator–Activated Receptor δ Gene Are Associated With Skeletal Muscle Glucose Uptake
Markku Vänttinen; Pirjo Nuutila; Teemu Kuulasmaa; Jussi Pihlajamäki; Kirsti Hällsten; Kirsi A. Virtanen; Riikka Lautamäki; Pauliina Peltoniemi; Teemu Takala; Antti P.M. Viljanen; Juhani Knuuti; Markku Laakso
Diabetes December 2005, Vol.54, 3587-3591. doi:https://doi.org/10.2337/diabetes.54.12.3587
Metabolism
Free Fatty Acids Produce Insulin Resistance and Activate the Proinflammatory Nuclear Factor-κB Pathway in Rat Liver
Guenther Boden; Pengxiang She; Maria Mozzoli; Peter Cheung; Kiranmai Gumireddy; Prekumar Reddy; Xiaqin Xiang; Zhijan Luo; Neil Ruderman
Diabetes December 2005, Vol.54, 3458-3465. doi:https://doi.org/10.2337/diabetes.54.12.3458
Glucose Metabolism in Mice Lacking Muscle Glycogen Synthase
Bartholomew A. Pederson; Jill M. Schroeder; Gretchen E. Parker; Micah W. Smith; Anna A. DePaoli-Roach; Peter J. Roach
Diabetes December 2005, Vol.54, 3466-3473. doi:https://doi.org/10.2337/diabetes.54.12.3466
Pathophysiology
Unraveling the Temporal Pattern of Diet-Induced Insulin Resistance in Individual Organs and Cardiac Dysfunction in c57bl/6 Mice
So-Young Park; You-Ree Cho; Hyo-Jeong Kim; Takamasa Higashimori; Cheryl Danton; Mi-Kyung Lee; Asim Dey; Beverly Rothermel; Young-Bum Kim; April Kalinowski; Kerry S. Russell; Jason K. Kim
Diabetes December 2005, Vol.54, 3530-3540. doi:https://doi.org/10.2337/diabetes.54.12.3530
Nonalcoholic Fatty Liver Disease and Risk of Future Cardiovascular Events Among Type 2 Diabetic Patients
Giovanni Targher; Lorenzo Bertolini; Felice Poli; Stefano Rodella; Luca Scala; Roberto Tessari; Luciano Zenari; Giancarlo Falezza
Diabetes December 2005, Vol.54, 3541-3546. doi:https://doi.org/10.2337/diabetes.54.12.3541
Genetics
A Functional Variant in the Human Betacellulin Gene Promoter Is Associated With Type 2 Diabetes
Yoshio Nakano; Hiroto Furuta; Asako Doi; Shohei Matsuno; Takayuki Nakagawa; Hiroko Shimomura; Setsuya Sakagashira; Yukio Horikawa; Masahiro Nishi; Hideyuki Sasaki; Tokio Sanke; Kishio Nanjo
Diabetes December 2005, Vol.54, 3560-3566. doi:https://doi.org/10.2337/diabetes.54.12.3560
HFE Genetic Variability, Body Iron Stores, and the Risk of Type 2 Diabetes in U.S. Women
Diabetes December 2005, Vol.54, 3567-3572. doi:https://doi.org/10.2337/diabetes.54.12.3567
Perspectives in Diabetes
Mechanisms of Hypoglycemia-Associated Autonomic Failure and Its Component Syndromes in Diabetes
Diabetes December 2005, Vol.54, 3592-3601. doi:https://doi.org/10.2337/diabetes.54.12.3592
