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OSA Lecture 2004

Thirty Years of Investigating the Autoimmune Basis for Type 1 Diabetes: Why Can’t We Prevent or Reverse This Disease?

Mark A. Atkinson

Abstract

View articletitled, Thirty Years of Investigating the Autoimmune Basis for Type 1 Diabetes: Why Can’t We Prevent or Reverse This Disease?

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Topics: diabetes mellitus, type 1 , autoimmunity

Diabetes May 2005, Vol.54, 1253-1263. doi:https://doi.org/10.2337/diabetes.54.5.1253

Perspectives in Diabetes

Insulin Signaling in the Central Nervous System: A Critical Role in Metabolic Homeostasis and Disease From C. elegans to Humans

Daniel Porte, Jr.; Denis G. Baskin; Michael W. Schwartz

Abstract

View articletitled, Insulin Signaling in the Central Nervous System: A Critical Role in Metabolic Homeostasis and Disease From C. elegans to Humans

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Topics: insulin , signal transduction , obesity

Diabetes May 2005, Vol.54, 1264-1276. doi:https://doi.org/10.2337/diabetes.54.5.1264

Metabolism

Glycogen Synthesis in Human Gastrocnemius Muscle Is Not Representative of Whole-Body Muscle Glycogen Synthesis

Mireille J.M. Serlie; Jacco H. de Haan; Cees J. Tack; Hein J. Verberne; Mariette T. Ackermans; Arend Heerschap; Hans P. Sauerwein

Abstract

View articletitled, Glycogen Synthesis in Human Gastrocnemius Muscle Is Not Representative of Whole-Body Muscle Glycogen Synthesis

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Topics: glucose , glycogen synthesis , insulin , isotopes , gastrocnemius muscle

Diabetes May 2005, Vol.54, 1277-1282. doi:https://doi.org/10.2337/diabetes.54.5.1277

Proteome Analysis of Skeletal Muscle From Obese and Morbidly Obese Women

Dustin S. Hittel; Yetrib Hathout; Eric P. Hoffman; Joseph A. Houmard

Abstract

View articletitled, Proteome Analysis of Skeletal Muscle From Obese and Morbidly Obese Women

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Topics: obesity , obesity, morbid , skeletal muscles , overweight , gel

Diabetes May 2005, Vol.54, 1283-1288. doi:https://doi.org/10.2337/diabetes.54.5.1283

Impact of Genetic Versus Environmental Factors on the Control of Muscle Glycogen Synthase Activation in Twins

Pernille Poulsen; Jørgen F.P. Wojtaszewski; Inge Petersen; Kaare Christensen; Erik A. Richter; Henning Beck-Nielsen; Allan Vaag

Abstract

View articletitled, Impact of Genetic Versus Environmental Factors on the Control of Muscle Glycogen Synthase Activation in Twins

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Topics: genetics , glycogen , glycogen (starch) synthase , glycogen synthase kinase 3 , insulin

Diabetes May 2005, Vol.54, 1289-1296. doi:https://doi.org/10.2337/diabetes.54.5.1289

Oscillations of Fatty Acid and Glycerol Release From Human Subcutaneous Adipose Tissue In Vivo

Fredrik Karpe; Barbara A. Fielding; Simon W. Coppack; Victor J. Lawrence; Ian A. Macdonald; Keith N. Frayn

Abstract

View articletitled, Oscillations of Fatty Acid and Glycerol Release From Human Subcutaneous Adipose Tissue In Vivo

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Topics: glycerol , insulin , nonesterified fatty acids , norepinephrine , fat, subcutaneous

Diabetes May 2005, Vol.54, 1297-1303. doi:https://doi.org/10.2337/diabetes.54.5.1297

Signal Transduction

Adenovirus-Mediated Adiponectin Expression Augments Skeletal Muscle Insulin Sensitivity in Male Wistar Rats

Hiroaki Satoh; M.T. Audrey Nguyen; Maria Trujillo; Takeshi Imamura; Isao Usui; Philipp E. Scherer; Jerrold M. Olefsky

Abstract

View articletitled, Adenovirus-Mediated Adiponectin Expression Augments Skeletal Muscle Insulin Sensitivity in Male Wistar Rats

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Topics: adiponectin , insulin , rats , skeletal muscles , adenoviruses

Diabetes May 2005, Vol.54, 1304-1313. doi:https://doi.org/10.2337/diabetes.54.5.1304

Effects of Diet and Genetic Background on Sterol Regulatory Element-Binding Protein-1c, Stearoyl-CoA Desaturase 1, and the Development of the Metabolic Syndrome

Sudha B. Biddinger; Katrine Almind; Makoto Miyazaki; Efi Kokkotou; James M. Ntambi; C. Ronald Kahn

Abstracts

View articletitled, Effects of Diet and Genetic Background on Sterol Regulatory Element-Binding Protein-1c, Stearoyl-CoA Desaturase 1, and the Development of the Metabolic Syndrome

Supplementary data

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Topics: diet , lipids , mice , genetic background , stearoyl-coa desaturase

Diabetes May 2005, Vol.54, 1314-1323. doi:https://doi.org/10.2337/diabetes.54.5.1314

Parasympathetic Innervation and Function of Endocrine Pancreas Requires the Glial Cell Line–Derived Factor Family Receptor α2 (GFRα2)

Jari Rossi; Paavo Santamäki; Matti S. Airaksinen; Karl-Heinz Herzig

Abstracts

View articletitled, Parasympathetic Innervation and Function of Endocrine Pancreas Requires the Glial Cell Line–Derived Factor Family Receptor α2 (GFRα2)

Supplementary data

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Topics: endocrine pancreas , mice , nerve supply , insulin , neuroglia

Diabetes May 2005, Vol.54, 1324-1330. doi:https://doi.org/10.2337/diabetes.54.5.1324

Short-Term Overexpression of a Constitutively Active Form of AMP-Activated Protein Kinase in the Liver Leads to Mild Hypoglycemia and Fatty Liver

Marc Foretz; Nicolas Ancellin; Fabrizio Andreelli; Yannick Saintillan; Pascal Grondin; Axel Kahn; Bernard Thorens; Sophie Vaulont; Benoît Viollet

Abstracts

View articletitled, Short-Term Overexpression of a Constitutively Active Form of AMP-Activated Protein Kinase in the Liver Leads to Mild Hypoglycemia and Fatty Liver

Supplementary data

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Topics: ampk , fatty liver , glucose , hypoglycemia , liver

Diabetes May 2005, Vol.54, 1331-1339. doi:https://doi.org/10.2337/diabetes.54.5.1331

A Role for iNOS in Fasting Hyperglycemia and Impaired Insulin Signaling in the Liver of Obese Diabetic Mice

Masaki Fujimoto; Nobuyuki Shimizu; Kaiko Kunii; J.A. Jeevendra Martyn; Kohjiro Ueki; Masao Kaneki

Abstracts

View articletitled, A Role for iNOS in Fasting Hyperglycemia and Impaired Insulin Signaling in the Liver of Obese Diabetic Mice

Supplementary data

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Topics: insulin , liver , mice , nitric oxide synthase , irs1 protein, human

Diabetes May 2005, Vol.54, 1340-1348. doi:https://doi.org/10.2337/diabetes.54.5.1340

Akt2 Is Essential for the Full Effect of Calorie Restriction on Insulin-Stimulated Glucose Uptake in Skeletal Muscle

Carrie E. McCurdy; Gregory D. Cartee

Abstract

View articletitled, Akt2 Is Essential for the Full Effect of Calorie Restriction on Insulin-Stimulated Glucose Uptake in Skeletal Muscle

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Topics: calorie restricted diet , insulin , mice , phosphorylation , serine

Diabetes May 2005, Vol.54, 1349-1356. doi:https://doi.org/10.2337/diabetes.54.5.1349

Essential Role of Chicken Ovalbumin Upstream Promoter-Transcription Factor II in Insulin Secretion and Insulin Sensitivity Revealed by Conditional Gene Knockout

Pascale Bardoux; Pili Zhang; Daisy Flamez; Anaïs Perilhou; Tiphaine Aguirre Lavin; Jean-François Tanti; Karine Hellemans; Emmanuel Gomas; Cécile Godard; Fabrizio Andreelli; Maria Antonietta Buccheri; Axel Kahn; Yannick Le Marchand-Brustel; Rémy Burcelin; Frans Schuit; Mireille Vasseur-Cognet

Abstracts

View articletitled, Essential Role of Chicken Ovalbumin Upstream Promoter-Transcription Factor II in Insulin Secretion and Insulin Sensitivity Revealed by Conditional Gene Knockout

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Topics: glucose , insulin , insulin secretion , mice , insulin sensitivity

Diabetes May 2005, Vol.54, 1357-1363. doi:https://doi.org/10.2337/diabetes.54.5.1357

Obesity Studies

The Contribution of Visceral Adipose Tissue to Splanchnic Cortisol Production in Healthy Humans

Ruth Andrew; Jukka Westerbacka; John Wahren; Hannele Yki-Järvinen; Brian R. Walker

Abstracts

View articletitled, The Contribution of Visceral Adipose Tissue to Splanchnic Cortisol Production in Healthy Humans

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Topics: cortisone , hydrocortisone , steady state , visceral fat

Diabetes May 2005, Vol.54, 1364-1370. doi:https://doi.org/10.2337/diabetes.54.5.1364

Differential Association of Basal and Postprandial Plasma Ghrelin With Leptin, Insulin, and Type 2 Diabetes

Johannes Erdmann; Florian Lippl; Stefan Wagenpfeil; Volker Schusdziarra

Abstracts

View articletitled, Differential Association of Basal and Postprandial Plasma Ghrelin With Leptin, Insulin, and Type 2 Diabetes

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Topics: ghrelin , insulin , leptin , obesity , postprandial period

Diabetes May 2005, Vol.54, 1371-1378. doi:https://doi.org/10.2337/diabetes.54.5.1371

Rosiglitazone Increases Indexes of Stearoyl-CoA Desaturase Activity in Humans: Link to Insulin Sensitization and the Role of Dominant-Negative Mutation in Peroxisome Proliferator-Activated Receptor-γ

Ulf Risérus; Garry D. Tan; Barbara A. Fielding; Matt J. Neville; Jenny Currie; David B. Savage; V. Krishna Chatterjee; Keith N. Frayn; Stephen O’Rahilly; Fredrik Karpe

Abstracts

View articletitled, Rosiglitazone Increases Indexes of Stearoyl-CoA Desaturase Activity in Humans: Link to Insulin Sensitization and the Role of Dominant-Negative Mutation in Peroxisome Proliferator-Activated Receptor-γ

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Topics: fatty acids , insulin , insulin sensitivity , rosiglitazone , peroxisome

Diabetes May 2005, Vol.54, 1379-1384. doi:https://doi.org/10.2337/diabetes.54.5.1379

Uncoupling Protein 1 Is Necessary for Norepinephrine-Induced Glucose Utilization in Brown Adipose Tissue

Ken-ichi Inokuma; Yuko Ogura-Okamatsu; Chitoku Toda; Kazuhiro Kimura; Hitoshi Yamashita; Masayuki Saito

Abstract

View articletitled, Uncoupling Protein 1 Is Necessary for Norepinephrine-Induced Glucose Utilization in Brown Adipose Tissue

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Topics: adenylate kinase , brown fat , glucose , insulin , mice

Diabetes May 2005, Vol.54, 1385-1391. doi:https://doi.org/10.2337/diabetes.54.5.1385

Pioglitazone Induces Mitochondrial Biogenesis in Human Subcutaneous Adipose Tissue In Vivo

Iwona Bogacka; Hui Xie; George A. Bray; Steven R. Smith

Abstracts

View articletitled, Pioglitazone Induces Mitochondrial Biogenesis in Human Subcutaneous Adipose Tissue In Vivo

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Topics: dna, mitochondrial , mitochondria , peroxisome proliferator-activated receptors , pioglitazone , origin of life

Diabetes May 2005, Vol.54, 1392-1399. doi:https://doi.org/10.2337/diabetes.54.5.1392

Immunology and Transplantation

Donor Treatment With Carbon Monoxide Can Yield Islet Allograft Survival and Tolerance

Hongjun Wang; Soo Sun Lee; Wenda Gao; Eva Czismadia; James McDaid; Robert Öllinger; Miguel P. Soares; Kenichiro Yamashita; Fritz H. Bach

Abstracts

View articletitled, Donor Treatment With Carbon Monoxide Can Yield Islet Allograft Survival and Tolerance

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Topics: cytokine , donors , reverse transcriptase polymerase chain reaction , tissue transplants , transplantation

Diabetes May 2005, Vol.54, 1400-1406. doi:https://doi.org/10.2337/diabetes.54.5.1400

Functional Defects and the Influence of Age on the Frequency of CD4⁺CD25⁺ T-Cells in Type 1 Diabetes

Todd M. Brusko; Clive H. Wasserfall; Michael J. Clare-Salzler; Desmond A. Schatz; Mark A. Atkinson

Abstract

View articletitled, Functional Defects and the Influence of Age on the Frequency of CD4+CD25+ T-Cells in Type 1 Diabetes

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Topics: antigens, cd25 , diabetes mellitus, type 1 , t-lymphocytes , regulatory t-lymphocytes , cytokine

Diabetes May 2005, Vol.54, 1407-1414. doi:https://doi.org/10.2337/diabetes.54.5.1407

Autoimmune Diabetes Onset Results From Qualitative Rather Than Quantitative Age-Dependent Changes in Pathogenic T-Cells

Sylvaine You; Mériam Belghith; Stephen Cobbold; Marie-Alexandra Alyanakian; Christine Gouarin; Samia Barriot; Corinne Garcia; Herman Waldmann; Jean-François Bach; Lucienne Chatenoud

Abstract

View articletitled, Autoimmune Diabetes Onset Results From Qualitative Rather Than Quantitative Age-Dependent Changes in Pathogenic T-Cells

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Topics: antigens, cd25 , mice , mice, inbred nod , t-lymphocytes , regulatory t-lymphocytes

Diabetes May 2005, Vol.54, 1415-1422. doi:https://doi.org/10.2337/diabetes.54.5.1415

Tumor Suppressor p53 Inhibits Autoimmune Inflammation and Macrophage Function

Shi-Jun Zheng; Salah-Eddine Lamhamedi-Cherradi; Pu Wang; Lingyun Xu; Youhai H. Chen

Abstracts

View articletitled, Tumor Suppressor p53 Inhibits Autoimmune Inflammation and Macrophage Function

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Topics: cytokine , inflammation , macrophages , mice , protein p53

Diabetes May 2005, Vol.54, 1423-1428. doi:https://doi.org/10.2337/diabetes.54.5.1423

Islet Studies

Sphingosine Kinase Activity and Sphingosine-1 Phosphate Production in Rat Pancreatic Islets and INS-1 Cells: Response to Cytokines

Lucy D. Mastrandrea; Shawn M. Sessanna; Suzanne G. Laychock

Abstract

View articletitled, Sphingosine Kinase Activity and Sphingosine-1 Phosphate Production in Rat Pancreatic Islets and INS-1 Cells: Response to Cytokines

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Topics: cytokine , phosphates , phosphotransferases , rna, messenger , sphingosine

Diabetes May 2005, Vol.54, 1429-1436. doi:https://doi.org/10.2337/diabetes.54.5.1429

MnSOD and Catalase Transgenes Demonstrate That Protection of Islets From Oxidative Stress Does Not Alter Cytokine Toxicity

Hainan Chen; Xiaoyan Li; Paul N. Epstein

Abstracts

View articletitled, MnSOD and Catalase Transgenes Demonstrate That Protection of Islets From Oxidative Stress Does Not Alter Cytokine Toxicity

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Topics: catalase , cytokine , toxic effect , transgenes , antioxidants

Diabetes May 2005, Vol.54, 1437-1446. doi:https://doi.org/10.2337/diabetes.54.5.1437

Pathophysiology

Insulin Signaling in the Central Nervous System Is Critical for the Normal Sympathoadrenal Response to Hypoglycemia

Simon J. Fisher; Jens C. Brüning; Scott Lannon; C. Ronald Kahn

Abstracts

View articletitled, Insulin Signaling in the Central Nervous System Is Critical for the Normal Sympathoadrenal Response to Hypoglycemia

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Topics: central nervous system , glucose , hypoglycemia , insulin , mice

Diabetes May 2005, Vol.54, 1447-1451. doi:https://doi.org/10.2337/diabetes.54.5.1447

Pyruvate Administered After Severe Hypoglycemia Reduces Neuronal Death and Cognitive Impairment

Sang Won Suh; Koji Aoyama; Yasuhiko Matsumori; Jialing Liu; Raymond A. Swanson

Abstract

View articletitled, Pyruvate Administered After Severe Hypoglycemia Reduces Neuronal Death and Cognitive Impairment

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Topics: hypoglycemia , pyruvates , glucose , brain

Diabetes May 2005, Vol.54, 1452-1458. doi:https://doi.org/10.2337/diabetes.54.5.1452

Effects of Metformin and Rosiglitazone Treatment on Insulin Signaling and Glucose Uptake in Patients With Newly Diagnosed Type 2 Diabetes: A Randomized Controlled Study

Håkan K.R. Karlsson; Kirsti Hällsten; Marie Björnholm; Hiroki Tsuchida; Alexander V. Chibalin; Kirsi A. Virtanen; Olli J. Heinonen; Fredrik Lönnqvist; Pirjo Nuutila; Juleen R. Zierath

Abstract

View articletitled, Effects of Metformin and Rosiglitazone Treatment on Insulin Signaling and Glucose Uptake in Patients With Newly Diagnosed Type 2 Diabetes: A Randomized Controlled Study

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Topics: 1-phosphatidylinositol 3-kinase , diabetes mellitus, type 2 , glucose uptake , insulin , irs1 protein, human

Diabetes May 2005, Vol.54, 1459-1467. doi:https://doi.org/10.2337/diabetes.54.5.1459

Demonstration of a Hyperglycemia-Driven Pathogenic Abnormality of Copper Homeostasis in Diabetes and Its Reversibility by Selective Chelation: Quantitative Comparisons Between the Biology of Copper and Eight Other Nutritionally Essential Elements in Normal and Diabetic Individuals

Garth J.S. Cooper; Yih-Kai Chan; Ajith M. Dissanayake; Fiona E. Leahy; Geraldine F. Keogh; Chris M. Frampton; Gregory D. Gamble; Dianne H. Brunton; John R. Baker; Sally D. Poppitt

Abstracts

View articletitled, Demonstration of a Hyperglycemia-Driven Pathogenic Abnormality of Copper Homeostasis in Diabetes and Its Reversibility by Selective Chelation: Quantitative Comparisons Between the Biology of Copper and Eight Other Nutritionally Essential Elements in Normal and Diabetic Individuals

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Topics: excretory function , trientine , urinary tract , hemoglobin a, glycosylated , copper

Diabetes May 2005, Vol.54, 1468-1476. doi:https://doi.org/10.2337/diabetes.54.5.1468

Complications

G(−) Anaerobes–Reactive CD4⁺ T-Cells Trigger RANKL-Mediated Enhanced Alveolar Bone Loss in Diabetic NOD Mice

Deeqa A. Mahamed; Annette Marleau; Mawadda Alnaeeli; Bhagirath Singh; Xiaoxia Zhang; Joseph M. Penninger; Yen-Tung A. Teng

Abstract

View articletitled, G(−) Anaerobes–Reactive CD4+ T-Cells Trigger RANKL-Mediated Enhanced Alveolar Bone Loss in Diabetic NOD Mice

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Topics: alveolar bone loss , mice , mice, inbred nod , prediabetes , t-lymphocytes

Diabetes May 2005, Vol.54, 1477-1486. doi:https://doi.org/10.2337/diabetes.54.5.1477

Nonproteinuric Diabetes-Associated Nephropathy in the Cohen Rat Model of Type 2 Diabetes

Chana Yagil; Adiel Barak; David Ben-Dor; Eliezer Rosenmann; Joel Bernheim; Mordechai Rosner; Yael Segev; Sarah Weksler-Zangen; Itamar Raz; Yoram Yagil

Abstract

View articletitled, Nonproteinuric Diabetes-Associated Nephropathy in the Cohen Rat Model of Type 2 Diabetes

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Topics: calmodulin , chanarin-dorfman disease , clinical dementia rating scale , complementarity determining regions , creatinine clearance

Diabetes May 2005, Vol.54, 1487-1496. doi:https://doi.org/10.2337/diabetes.54.5.1487

The Effect of C-Peptide on Cognitive Dysfunction and Hippocampal Apoptosis in Type 1 Diabetic Rats

Anders A.F. Sima; Zhen-guo Li

Abstract

View articletitled, The Effect of C-Peptide on Cognitive Dysfunction and Hippocampal Apoptosis in Type 1 Diabetic Rats

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Topics: c-peptide , rats , hippocampus , apoptosis

Diabetes May 2005, Vol.54, 1497-1505. doi:https://doi.org/10.2337/diabetes.54.5.1497

Linoleic Acid Increases Lectin-Like Oxidized LDL Receptor-1 (LOX-1) Expression in Human Aortic Endothelial Cells

Fritz Maingrette; Geneviève Renier

Abstract

View articletitled, Linoleic Acid Increases Lectin-Like Oxidized LDL Receptor-1 (LOX-1) Expression in Human Aortic Endothelial Cells

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Topics: actins , aorta , endothelial cells , endothelium , genes

Diabetes May 2005, Vol.54, 1506-1513. doi:https://doi.org/10.2337/diabetes.54.5.1506

Low-Dose Poly(ADP-Ribose) Polymerase Inhibitor-Containing Combination Therapies Reverse Early Peripheral Diabetic Neuropathy

Fei Li; Viktor R. Drel; Csaba Szabó; Martin J. Stevens; Irina G. Obrosova

Abstract

View articletitled, Low-Dose Poly(ADP-Ribose) Polymerase Inhibitor-Containing Combination Therapies Reverse Early Peripheral Diabetic Neuropathy

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Topics: adenosine diphosphate ribose , diabetic neuropathies , international organization for standardization , poly(adp-ribose) polymerases , rats

Diabetes May 2005, Vol.54, 1514-1522. doi:https://doi.org/10.2337/diabetes.54.5.1514

Mannose-Binding Lectin as a Predictor of Microalbuminuria in Type 1 Diabetes: An Inception Cohort Study

Peter Hovind; Troels Krarup Hansen; Lise Tarnow; Steffen Thiel; Rudi Steffensen; Allan Flyvbjerg; Hans-Henrik Parving

Abstract

View articletitled, Mannose-Binding Lectin as a Predictor of Microalbuminuria in Type 1 Diabetes: An Inception Cohort Study

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Topics: diabetes mellitus, type 1 , mannose binding lectin , microalbuminuria , microbiology procedures , complement system proteins

Diabetes May 2005, Vol.54, 1523-1527. doi:https://doi.org/10.2337/diabetes.54.5.1523

Reduced Insulin and IGF-I Signaling, not Hyperglycemia, Underlies the Diabetes-Associated Depletion of Interstitial Cells of Cajal in the Murine Stomach

Viktor J. Horváth; Harsha Vittal; Tamás Ördög

Abstract

View articletitled, Reduced Insulin and IGF-I Signaling, not Hyperglycemia, Underlies the Diabetes-Associated Depletion of Interstitial Cells of Cajal in the Murine Stomach

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Topics: hyperglycemia , insulin , insulin-like growth factor i , interstitial cells of cajal , mice

Diabetes May 2005, Vol.54, 1528-1533. doi:https://doi.org/10.2337/diabetes.54.5.1528

Neutrophils Are Associated With Capillary Closure in Spontaneously Diabetic Monkey Retinas

Sahng Y. Kim; Mary A. Johnson; D. Scott McLeod; Theresa Alexander; Barbara C. Hansen; Gerard A. Lutty

Abstract

View articletitled, Neutrophils Are Associated With Capillary Closure in Spontaneously Diabetic Monkey Retinas

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Topics: apyrase , blood capillaries , cercopithecidae , neutrophils , retina

Diabetes May 2005, Vol.54, 1534-1542. doi:https://doi.org/10.2337/diabetes.54.5.1534

Wound Inflammation in Diabetic ob/ob Mice : Functional Coupling of Prostaglandin Biosynthesis to Cyclooxygenase-1 Activity in Diabetes-Impaired Wound Healing

Heiko Kämpfer; Ronald Schmidt; Gerd Geisslinger; Josef Pfeilschifter; Stefan Frank

Abstract

View articletitled, Wound Inflammation in Diabetic ob/ob Mice : Functional Coupling of Prostaglandin Biosynthesis to Cyclooxygenase-1 Activity in Diabetes-Impaired Wound Healing

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Topics: biosynthesis , cyclooxygenase-1 , cyclooxygenase-2 , inflammation , leptin

Diabetes May 2005, Vol.54, 1543-1551. doi:https://doi.org/10.2337/diabetes.54.5.1543

Pharmacology and Therapeutics

Inhibitory Effects of Antipsychotics on Carbachol-Enhanced Insulin Secretion From Perifused Rat Islets: Role of Muscarinic Antagonism in Antipsychotic-Induced Diabetes and Hyperglycemia

David E. Johnson; Hanae Yamazaki; Karen M. Ward; Anne W. Schmidt; Wesley S. Lebel; Judith L. Treadway; E. Michael Gibbs; Walter S. Zawalich; Hans Rollema

Abstracts

View articletitled, Inhibitory Effects of Antipsychotics on Carbachol-Enhanced Insulin Secretion From Perifused Rat Islets: Role of Muscarinic Antagonism in Antipsychotic-Induced Diabetes and Hyperglycemia

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Topics: antagonists , antipsychotic agents , carbachol , clozapine , glucose

Diabetes May 2005, Vol.54, 1552-1558. doi:https://doi.org/10.2337/diabetes.54.5.1552

Minocycline Reduces Proinflammatory Cytokine Expression, Microglial Activation, and Caspase-3 Activation in a Rodent Model of Diabetic Retinopathy

J. Kyle Krady; Anirban Basu; Colleen M. Allen; Yuping Xu; Kathryn F. LaNoue; Thomas W. Gardner; Steven W. Levison

Abstract

View articletitled, Minocycline Reduces Proinflammatory Cytokine Expression, Microglial Activation, and Caspase-3 Activation in a Rodent Model of Diabetic Retinopathy

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Topics: caspase-3 , cytokine , diabetic retinopathy , microglia , minocycline

Diabetes May 2005, Vol.54, 1559-1565. doi:https://doi.org/10.2337/diabetes.54.5.1559

Intensive Lifestyle Intervention or Metformin on Inflammation and Coagulation in Participants With Impaired Glucose Tolerance

The Diabetes Prevention Program Research Group

Abstracts

View articletitled, Intensive Lifestyle Intervention or Metformin on Inflammation and Coagulation in Participants With Impaired Glucose Tolerance

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Topics: c-reactive protein , fibrinogen , glucose intolerance , inflammation , insulin resistance

Diabetes May 2005, Vol.54, 1566-1572. doi:https://doi.org/10.2337/diabetes.54.5.1566

Kallikrein Gene Delivery Improves Serum Glucose and Lipid Profiles and Cardiac Function in Streptozotocin-Induced Diabetic Rats

David Montanari; Hang Yin; Eric Dobrzynski; Jun Agata; Hideaki Yoshida; Julie Chao; Lee Chao

Abstract

View articletitled, Kallikrein Gene Delivery Improves Serum Glucose and Lipid Profiles and Cardiac Function in Streptozotocin-Induced Diabetic Rats

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Topics: genes , kininogenase , rats , streptozocin , tissue kallikrein

Diabetes May 2005, Vol.54, 1573-1580. doi:https://doi.org/10.2337/diabetes.54.5.1573

Genetics

Subcellular Localization of ALMS1 Supports Involvement of Centrosome and Basal Body Dysfunction in the Pathogenesis of Obesity, Insulin Resistance, and Type 2 Diabetes

Tom Hearn; Cosma Spalluto; Victoria J. Phillips; Glenn L. Renforth; Nane Copin; Neil A. Hanley; David I. Wilson

Abstract

View articletitled, Subcellular Localization of ALMS1 Supports Involvement of Centrosome and Basal Body Dysfunction in the Pathogenesis of Obesity, Insulin Resistance, and Type 2 Diabetes

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Topics: alstrom syndrome , antibodies , centrosome , cilia , diabetes mellitus, type 2

Diabetes May 2005, Vol.54, 1581-1587. doi:https://doi.org/10.2337/diabetes.54.5.1581

Brief Genetics Reports

OAS1 Splice Site Polymorphism Controlling Antiviral Enzyme Activity Influences Susceptibility to Type 1 Diabetes

L. Leigh Field; Vagn Bonnevie-Nielsen; Flemming Pociot; Shao Lu; Thomas B. Nielsen; Henning Beck-Nielsen

Abstracts

View articletitled, OAS1 Splice Site Polymorphism Controlling Antiviral Enzyme Activity Influences Susceptibility to Type 1 Diabetes

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Topics: antiviral agents , diabetes mellitus, type 1 , enzyme activity , genotype , polymorphism

Diabetes May 2005, Vol.54, 1588-1591. doi:https://doi.org/10.2337/diabetes.54.5.1588

Single Nucleotide Polymorphisms in K_ATP Channels: Muscular Impact on Type 2 Diabetes

Li Li; Yun Shi; Xueren Wang; Weiwei Shi; Chun Jiang

Abstracts

View articletitled, Single Nucleotide Polymorphisms in KATP Channels: Muscular Impact on Type 2 Diabetes

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Topics: diabetes mellitus, type 2 , single nucleotide polymorphism , protons , obesity

Diabetes May 2005, Vol.54, 1592-1597. doi:https://doi.org/10.2337/diabetes.54.5.1592

Variations in Peptide YY and Y2 Receptor Genes Are Associated With Severe Obesity in Pima Indian Men

Lijun Ma; P. Antonio Tataranni; Robert L. Hanson; Aniello M. Infante; Sayuko Kobes; Clifton Bogardus; Leslie J. Baier

Abstracts

View articletitled, Variations in Peptide YY and Y2 Receptor Genes Are Associated With Severe Obesity in Pima Indian Men

Supplementary data

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Topics: genes , obesity , obesity, morbid , peptide yy , single nucleotide polymorphism

Diabetes May 2005, Vol.54, 1598-1602. doi:https://doi.org/10.2337/diabetes.54.5.1598

Major Histocompatibility Complex–Linked Diabetes Susceptibility in NOD/Lt Mice : Subcongenic Analysis Localizes a Component of Idd16 at the H2-D End of the Diabetogenic H2^g7 Complex

Darcy P. Pomerleau; Rebecca J. Bagley; David V. Serreze; Clayton E. Mathews; Edward H. Leiter

Abstract

View articletitled, Major Histocompatibility Complex–Linked Diabetes Susceptibility in NOD/Lt Mice : Subcongenic Analysis Localizes a Component of Idd16 at the H2-D End of the Diabetogenic H2g7 Complex

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Topics: alleles , alloxan , cataract , major histocompatibility complex , mice

Diabetes May 2005, Vol.54, 1603-1606. doi:https://doi.org/10.2337/diabetes.54.5.1603

The +276 Polymorphism of the APM1 Gene, Plasma Adiponectin Concentration, and Cardiovascular Risk in Diabetic Men

Lu Qi; Tricia Li; Eric Rimm; Cuilin Zhang; Nader Rifai; David Hunter; Alessandro Doria; Frank B. Hu

Abstract

View articletitled, The +276 Polymorphism of the APM1 Gene, Plasma Adiponectin Concentration, and Cardiovascular Risk in Diabetic Men

Supplementary data

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Topics: adiponectin , cardiovascular diseases , heart disease risk factors , plasma , genes

Diabetes May 2005, Vol.54, 1607-1610. doi:https://doi.org/10.2337/diabetes.54.5.1607

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