Issues

Topics: diabetes mellitus, type 1 , autoimmunity

Diabetes May 2005, Vol.54, 1253-1263. doi:https://doi.org/10.2337/diabetes.54.5.1253

Perspectives in Diabetes

Insulin Signaling in the Central Nervous System: A Critical Role in Metabolic Homeostasis and Disease From C. elegans to Humans

Daniel Porte, Jr.; Denis G. Baskin; Michael W. Schwartz

Abstract

Topics: insulin , signal transduction , obesity

Diabetes May 2005, Vol.54, 1264-1276. doi:https://doi.org/10.2337/diabetes.54.5.1264

Metabolism

Glycogen Synthesis in Human Gastrocnemius Muscle Is Not Representative of Whole-Body Muscle Glycogen Synthesis

Mireille J.M. Serlie; Jacco H. de Haan; Cees J. Tack; Hein J. Verberne; Mariette T. Ackermans; Arend Heerschap; Hans P. Sauerwein

Abstract

Topics: glucose , glycogen synthesis , insulin , isotopes , gastrocnemius muscle

Diabetes May 2005, Vol.54, 1277-1282. doi:https://doi.org/10.2337/diabetes.54.5.1277

Proteome Analysis of Skeletal Muscle From Obese and Morbidly Obese Women

Dustin S. Hittel; Yetrib Hathout; Eric P. Hoffman; Joseph A. Houmard

Abstract

Topics: obesity , obesity, morbid , skeletal muscles , overweight , gel

Diabetes May 2005, Vol.54, 1283-1288. doi:https://doi.org/10.2337/diabetes.54.5.1283

Impact of Genetic Versus Environmental Factors on the Control of Muscle Glycogen Synthase Activation in Twins

Pernille Poulsen; Jørgen F.P. Wojtaszewski; Inge Petersen; Kaare Christensen; Erik A. Richter; Henning Beck-Nielsen; Allan Vaag

Abstract

Topics: genetics , glycogen , glycogen (starch) synthase , glycogen synthase kinase 3 , insulin

Diabetes May 2005, Vol.54, 1289-1296. doi:https://doi.org/10.2337/diabetes.54.5.1289

Oscillations of Fatty Acid and Glycerol Release From Human Subcutaneous Adipose Tissue In Vivo

Fredrik Karpe; Barbara A. Fielding; Simon W. Coppack; Victor J. Lawrence; Ian A. Macdonald; Keith N. Frayn

Abstract

Topics: glycerol , insulin , nonesterified fatty acids , norepinephrine , fat, subcutaneous

Diabetes May 2005, Vol.54, 1297-1303. doi:https://doi.org/10.2337/diabetes.54.5.1297

Signal Transduction

Adenovirus-Mediated Adiponectin Expression Augments Skeletal Muscle Insulin Sensitivity in Male Wistar Rats

Hiroaki Satoh; M.T. Audrey Nguyen; Maria Trujillo; Takeshi Imamura; Isao Usui; Philipp E. Scherer; Jerrold M. Olefsky

Abstract

Topics: adiponectin , insulin , rats , skeletal muscles , adenoviruses

Diabetes May 2005, Vol.54, 1304-1313. doi:https://doi.org/10.2337/diabetes.54.5.1304

Effects of Diet and Genetic Background on Sterol Regulatory Element-Binding Protein-1c, Stearoyl-CoA Desaturase 1, and the Development of the Metabolic Syndrome

Sudha B. Biddinger; Katrine Almind; Makoto Miyazaki; Efi Kokkotou; James M. Ntambi; C. Ronald Kahn

Abstracts

Topics: diet , lipids , mice , genetic background , stearoyl-coa desaturase

Diabetes May 2005, Vol.54, 1314-1323. doi:https://doi.org/10.2337/diabetes.54.5.1314

Parasympathetic Innervation and Function of Endocrine Pancreas Requires the Glial Cell Line–Derived Factor Family Receptor α2 (GFRα2)

Jari Rossi; Paavo Santamäki; Matti S. Airaksinen; Karl-Heinz Herzig

Abstracts

Topics: endocrine pancreas , mice , nerve supply , insulin , neuroglia

Diabetes May 2005, Vol.54, 1324-1330. doi:https://doi.org/10.2337/diabetes.54.5.1324

Short-Term Overexpression of a Constitutively Active Form of AMP-Activated Protein Kinase in the Liver Leads to Mild Hypoglycemia and Fatty Liver

Marc Foretz; Nicolas Ancellin; Fabrizio Andreelli; Yannick Saintillan; Pascal Grondin; Axel Kahn; Bernard Thorens; Sophie Vaulont; Benoît Viollet

Abstracts

Topics: ampk , fatty liver , glucose , hypoglycemia , liver

Diabetes May 2005, Vol.54, 1331-1339. doi:https://doi.org/10.2337/diabetes.54.5.1331

A Role for iNOS in Fasting Hyperglycemia and Impaired Insulin Signaling in the Liver of Obese Diabetic Mice

Masaki Fujimoto; Nobuyuki Shimizu; Kaiko Kunii; J.A. Jeevendra Martyn; Kohjiro Ueki; Masao Kaneki

Abstracts

Topics: insulin , liver , mice , nitric oxide synthase , irs1 protein, human

Diabetes May 2005, Vol.54, 1340-1348. doi:https://doi.org/10.2337/diabetes.54.5.1340

Akt2 Is Essential for the Full Effect of Calorie Restriction on Insulin-Stimulated Glucose Uptake in Skeletal Muscle

Carrie E. McCurdy; Gregory D. Cartee

Abstract

Topics: calorie restricted diet , insulin , mice , phosphorylation , serine

Diabetes May 2005, Vol.54, 1349-1356. doi:https://doi.org/10.2337/diabetes.54.5.1349

Essential Role of Chicken Ovalbumin Upstream Promoter-Transcription Factor II in Insulin Secretion and Insulin Sensitivity Revealed by Conditional Gene Knockout

Pascale Bardoux; Pili Zhang; Daisy Flamez; Anaïs Perilhou; Tiphaine Aguirre Lavin; Jean-François Tanti; Karine Hellemans; Emmanuel Gomas; Cécile Godard; Fabrizio Andreelli; Maria Antonietta Buccheri; Axel Kahn; Yannick Le Marchand-Brustel; Rémy Burcelin; Frans Schuit; Mireille Vasseur-Cognet

Abstracts

Topics: glucose , insulin , insulin secretion , mice , insulin sensitivity

Diabetes May 2005, Vol.54, 1357-1363. doi:https://doi.org/10.2337/diabetes.54.5.1357

Obesity Studies

The Contribution of Visceral Adipose Tissue to Splanchnic Cortisol Production in Healthy Humans

Ruth Andrew; Jukka Westerbacka; John Wahren; Hannele Yki-Järvinen; Brian R. Walker

Abstracts

Topics: cortisone , hydrocortisone , steady state , visceral fat

Diabetes May 2005, Vol.54, 1364-1370. doi:https://doi.org/10.2337/diabetes.54.5.1364

Differential Association of Basal and Postprandial Plasma Ghrelin With Leptin, Insulin, and Type 2 Diabetes

Johannes Erdmann; Florian Lippl; Stefan Wagenpfeil; Volker Schusdziarra

Abstracts

Topics: ghrelin , insulin , leptin , obesity , postprandial period

Diabetes May 2005, Vol.54, 1371-1378. doi:https://doi.org/10.2337/diabetes.54.5.1371

Rosiglitazone Increases Indexes of Stearoyl-CoA Desaturase Activity in Humans: Link to Insulin Sensitization and the Role of Dominant-Negative Mutation in Peroxisome Proliferator-Activated Receptor-γ

Ulf Risérus; Garry D. Tan; Barbara A. Fielding; Matt J. Neville; Jenny Currie; David B. Savage; V. Krishna Chatterjee; Keith N. Frayn; Stephen O’Rahilly; Fredrik Karpe

Abstracts

Topics: fatty acids , insulin , insulin sensitivity , rosiglitazone , peroxisome

Diabetes May 2005, Vol.54, 1379-1384. doi:https://doi.org/10.2337/diabetes.54.5.1379

Uncoupling Protein 1 Is Necessary for Norepinephrine-Induced Glucose Utilization in Brown Adipose Tissue

Ken-ichi Inokuma; Yuko Ogura-Okamatsu; Chitoku Toda; Kazuhiro Kimura; Hitoshi Yamashita; Masayuki Saito

Abstract

Topics: adenylate kinase , brown fat , glucose , insulin , mice

Diabetes May 2005, Vol.54, 1385-1391. doi:https://doi.org/10.2337/diabetes.54.5.1385

Pioglitazone Induces Mitochondrial Biogenesis in Human Subcutaneous Adipose Tissue In Vivo

Iwona Bogacka; Hui Xie; George A. Bray; Steven R. Smith

Abstracts

Topics: dna, mitochondrial , mitochondria , peroxisome proliferator-activated receptors , pioglitazone , origin of life

Diabetes May 2005, Vol.54, 1392-1399. doi:https://doi.org/10.2337/diabetes.54.5.1392

Immunology and Transplantation

Donor Treatment With Carbon Monoxide Can Yield Islet Allograft Survival and Tolerance

Hongjun Wang; Soo Sun Lee; Wenda Gao; Eva Czismadia; James McDaid; Robert Öllinger; Miguel P. Soares; Kenichiro Yamashita; Fritz H. Bach

Abstracts

Topics: cytokine , donors , reverse transcriptase polymerase chain reaction , tissue transplants , transplantation

Diabetes May 2005, Vol.54, 1400-1406. doi:https://doi.org/10.2337/diabetes.54.5.1400

Functional Defects and the Influence of Age on the Frequency of CD4⁺CD25⁺ T-Cells in Type 1 Diabetes

Todd M. Brusko; Clive H. Wasserfall; Michael J. Clare-Salzler; Desmond A. Schatz; Mark A. Atkinson

Abstract

Topics: antigens, cd25 , diabetes mellitus, type 1 , t-lymphocytes , regulatory t-lymphocytes , cytokine

Diabetes May 2005, Vol.54, 1407-1414. doi:https://doi.org/10.2337/diabetes.54.5.1407

Autoimmune Diabetes Onset Results From Qualitative Rather Than Quantitative Age-Dependent Changes in Pathogenic T-Cells

Sylvaine You; Mériam Belghith; Stephen Cobbold; Marie-Alexandra Alyanakian; Christine Gouarin; Samia Barriot; Corinne Garcia; Herman Waldmann; Jean-François Bach; Lucienne Chatenoud

Abstract

Topics: antigens, cd25 , mice , mice, inbred nod , t-lymphocytes , regulatory t-lymphocytes

Diabetes May 2005, Vol.54, 1415-1422. doi:https://doi.org/10.2337/diabetes.54.5.1415

Tumor Suppressor p53 Inhibits Autoimmune Inflammation and Macrophage Function

Shi-Jun Zheng; Salah-Eddine Lamhamedi-Cherradi; Pu Wang; Lingyun Xu; Youhai H. Chen

Abstracts

Topics: cytokine , inflammation , macrophages , mice , protein p53

Diabetes May 2005, Vol.54, 1423-1428. doi:https://doi.org/10.2337/diabetes.54.5.1423

Islet Studies

Sphingosine Kinase Activity and Sphingosine-1 Phosphate Production in Rat Pancreatic Islets and INS-1 Cells: Response to Cytokines

Lucy D. Mastrandrea; Shawn M. Sessanna; Suzanne G. Laychock

Abstract

Topics: cytokine , phosphates , phosphotransferases , rna, messenger , sphingosine

Diabetes May 2005, Vol.54, 1429-1436. doi:https://doi.org/10.2337/diabetes.54.5.1429

MnSOD and Catalase Transgenes Demonstrate That Protection of Islets From Oxidative Stress Does Not Alter Cytokine Toxicity

Hainan Chen; Xiaoyan Li; Paul N. Epstein

Abstracts

Topics: catalase , cytokine , toxic effect , transgenes , antioxidants

Diabetes May 2005, Vol.54, 1437-1446. doi:https://doi.org/10.2337/diabetes.54.5.1437

Pathophysiology

Insulin Signaling in the Central Nervous System Is Critical for the Normal Sympathoadrenal Response to Hypoglycemia

Simon J. Fisher; Jens C. Brüning; Scott Lannon; C. Ronald Kahn

Abstracts

Topics: central nervous system , glucose , hypoglycemia , insulin , mice

Diabetes May 2005, Vol.54, 1447-1451. doi:https://doi.org/10.2337/diabetes.54.5.1447

Pyruvate Administered After Severe Hypoglycemia Reduces Neuronal Death and Cognitive Impairment

Sang Won Suh; Koji Aoyama; Yasuhiko Matsumori; Jialing Liu; Raymond A. Swanson

Abstract

Topics: hypoglycemia , pyruvates , glucose , brain

Diabetes May 2005, Vol.54, 1452-1458. doi:https://doi.org/10.2337/diabetes.54.5.1452

Effects of Metformin and Rosiglitazone Treatment on Insulin Signaling and Glucose Uptake in Patients With Newly Diagnosed Type 2 Diabetes: A Randomized Controlled Study

Håkan K.R. Karlsson; Kirsti Hällsten; Marie Björnholm; Hiroki Tsuchida; Alexander V. Chibalin; Kirsi A. Virtanen; Olli J. Heinonen; Fredrik Lönnqvist; Pirjo Nuutila; Juleen R. Zierath

Abstract

Topics: 1-phosphatidylinositol 3-kinase , diabetes mellitus, type 2 , glucose uptake , insulin , irs1 protein, human

Diabetes May 2005, Vol.54, 1459-1467. doi:https://doi.org/10.2337/diabetes.54.5.1459

Demonstration of a Hyperglycemia-Driven Pathogenic Abnormality of Copper Homeostasis in Diabetes and Its Reversibility by Selective Chelation: Quantitative Comparisons Between the Biology of Copper and Eight Other Nutritionally Essential Elements in Normal and Diabetic Individuals

Garth J.S. Cooper; Yih-Kai Chan; Ajith M. Dissanayake; Fiona E. Leahy; Geraldine F. Keogh; Chris M. Frampton; Gregory D. Gamble; Dianne H. Brunton; John R. Baker; Sally D. Poppitt

Abstracts

Topics: excretory function , trientine , urinary tract , hemoglobin a, glycosylated , copper

Diabetes May 2005, Vol.54, 1468-1476. doi:https://doi.org/10.2337/diabetes.54.5.1468

Complications

G(−) Anaerobes–Reactive CD4⁺ T-Cells Trigger RANKL-Mediated Enhanced Alveolar Bone Loss in Diabetic NOD Mice

Deeqa A. Mahamed; Annette Marleau; Mawadda Alnaeeli; Bhagirath Singh; Xiaoxia Zhang; Joseph M. Penninger; Yen-Tung A. Teng

Abstract

Topics: alveolar bone loss , mice , mice, inbred nod , prediabetes , t-lymphocytes

Diabetes May 2005, Vol.54, 1477-1486. doi:https://doi.org/10.2337/diabetes.54.5.1477

Nonproteinuric Diabetes-Associated Nephropathy in the Cohen Rat Model of Type 2 Diabetes

Chana Yagil; Adiel Barak; David Ben-Dor; Eliezer Rosenmann; Joel Bernheim; Mordechai Rosner; Yael Segev; Sarah Weksler-Zangen; Itamar Raz; Yoram Yagil

Abstract

Topics: calmodulin , chanarin-dorfman disease , clinical dementia rating scale , complementarity determining regions , creatinine clearance

Diabetes May 2005, Vol.54, 1487-1496. doi:https://doi.org/10.2337/diabetes.54.5.1487

The Effect of C-Peptide on Cognitive Dysfunction and Hippocampal Apoptosis in Type 1 Diabetic Rats

Anders A.F. Sima; Zhen-guo Li

Abstract

Topics: c-peptide , rats , hippocampus , apoptosis

Diabetes May 2005, Vol.54, 1497-1505. doi:https://doi.org/10.2337/diabetes.54.5.1497

Linoleic Acid Increases Lectin-Like Oxidized LDL Receptor-1 (LOX-1) Expression in Human Aortic Endothelial Cells

Fritz Maingrette; Geneviève Renier

Abstract

Topics: actins , aorta , endothelial cells , endothelium , genes

Diabetes May 2005, Vol.54, 1506-1513. doi:https://doi.org/10.2337/diabetes.54.5.1506

Low-Dose Poly(ADP-Ribose) Polymerase Inhibitor-Containing Combination Therapies Reverse Early Peripheral Diabetic Neuropathy

Fei Li; Viktor R. Drel; Csaba Szabó; Martin J. Stevens; Irina G. Obrosova

Abstract

Topics: adenosine diphosphate ribose , diabetic neuropathies , international organization for standardization , poly(adp-ribose) polymerases , rats

Diabetes May 2005, Vol.54, 1514-1522. doi:https://doi.org/10.2337/diabetes.54.5.1514

Mannose-Binding Lectin as a Predictor of Microalbuminuria in Type 1 Diabetes: An Inception Cohort Study

Peter Hovind; Troels Krarup Hansen; Lise Tarnow; Steffen Thiel; Rudi Steffensen; Allan Flyvbjerg; Hans-Henrik Parving

Abstract

Topics: diabetes mellitus, type 1 , mannose binding lectin , microalbuminuria , microbiology procedures , complement system proteins

Diabetes May 2005, Vol.54, 1523-1527. doi:https://doi.org/10.2337/diabetes.54.5.1523

Reduced Insulin and IGF-I Signaling, not Hyperglycemia, Underlies the Diabetes-Associated Depletion of Interstitial Cells of Cajal in the Murine Stomach

Viktor J. Horváth; Harsha Vittal; Tamás Ördög

Abstract

Topics: hyperglycemia , insulin , insulin-like growth factor i , interstitial cells of cajal , mice

Diabetes May 2005, Vol.54, 1528-1533. doi:https://doi.org/10.2337/diabetes.54.5.1528

Neutrophils Are Associated With Capillary Closure in Spontaneously Diabetic Monkey Retinas

Sahng Y. Kim; Mary A. Johnson; D. Scott McLeod; Theresa Alexander; Barbara C. Hansen; Gerard A. Lutty

Abstract

Topics: apyrase , blood capillaries , cercopithecidae , neutrophils , retina

Diabetes May 2005, Vol.54, 1534-1542. doi:https://doi.org/10.2337/diabetes.54.5.1534

Wound Inflammation in Diabetic ob/ob Mice : Functional Coupling of Prostaglandin Biosynthesis to Cyclooxygenase-1 Activity in Diabetes-Impaired Wound Healing

Heiko Kämpfer; Ronald Schmidt; Gerd Geisslinger; Josef Pfeilschifter; Stefan Frank

Abstract

Topics: biosynthesis , cyclooxygenase-1 , cyclooxygenase-2 , inflammation , leptin

Diabetes May 2005, Vol.54, 1543-1551. doi:https://doi.org/10.2337/diabetes.54.5.1543

Pharmacology and Therapeutics

Inhibitory Effects of Antipsychotics on Carbachol-Enhanced Insulin Secretion From Perifused Rat Islets: Role of Muscarinic Antagonism in Antipsychotic-Induced Diabetes and Hyperglycemia

David E. Johnson; Hanae Yamazaki; Karen M. Ward; Anne W. Schmidt; Wesley S. Lebel; Judith L. Treadway; E. Michael Gibbs; Walter S. Zawalich; Hans Rollema

Abstracts

Topics: antagonists , antipsychotic agents , carbachol , clozapine , glucose

Diabetes May 2005, Vol.54, 1552-1558. doi:https://doi.org/10.2337/diabetes.54.5.1552

Minocycline Reduces Proinflammatory Cytokine Expression, Microglial Activation, and Caspase-3 Activation in a Rodent Model of Diabetic Retinopathy

J. Kyle Krady; Anirban Basu; Colleen M. Allen; Yuping Xu; Kathryn F. LaNoue; Thomas W. Gardner; Steven W. Levison

Abstract

Topics: caspase-3 , cytokine , diabetic retinopathy , microglia , minocycline

Diabetes May 2005, Vol.54, 1559-1565. doi:https://doi.org/10.2337/diabetes.54.5.1559

Intensive Lifestyle Intervention or Metformin on Inflammation and Coagulation in Participants With Impaired Glucose Tolerance

The Diabetes Prevention Program Research Group

Abstracts

Topics: c-reactive protein , fibrinogen , glucose intolerance , inflammation , insulin resistance

Diabetes May 2005, Vol.54, 1566-1572. doi:https://doi.org/10.2337/diabetes.54.5.1566

Kallikrein Gene Delivery Improves Serum Glucose and Lipid Profiles and Cardiac Function in Streptozotocin-Induced Diabetic Rats

David Montanari; Hang Yin; Eric Dobrzynski; Jun Agata; Hideaki Yoshida; Julie Chao; Lee Chao

Abstract

Topics: genes , kininogenase , rats , streptozocin , tissue kallikrein

Diabetes May 2005, Vol.54, 1573-1580. doi:https://doi.org/10.2337/diabetes.54.5.1573

Genetics

Subcellular Localization of ALMS1 Supports Involvement of Centrosome and Basal Body Dysfunction in the Pathogenesis of Obesity, Insulin Resistance, and Type 2 Diabetes

Tom Hearn; Cosma Spalluto; Victoria J. Phillips; Glenn L. Renforth; Nane Copin; Neil A. Hanley; David I. Wilson

Abstract

Topics: alstrom syndrome , antibodies , centrosome , cilia , diabetes mellitus, type 2

Diabetes May 2005, Vol.54, 1581-1587. doi:https://doi.org/10.2337/diabetes.54.5.1581

Brief Genetics Reports

OAS1 Splice Site Polymorphism Controlling Antiviral Enzyme Activity Influences Susceptibility to Type 1 Diabetes

L. Leigh Field; Vagn Bonnevie-Nielsen; Flemming Pociot; Shao Lu; Thomas B. Nielsen; Henning Beck-Nielsen

Abstracts

Topics: antiviral agents , diabetes mellitus, type 1 , enzyme activity , genotype , polymorphism

Diabetes May 2005, Vol.54, 1588-1591. doi:https://doi.org/10.2337/diabetes.54.5.1588

Single Nucleotide Polymorphisms in K_ATP Channels: Muscular Impact on Type 2 Diabetes

Li Li; Yun Shi; Xueren Wang; Weiwei Shi; Chun Jiang

Abstracts

Topics: diabetes mellitus, type 2 , single nucleotide polymorphism , protons , obesity

Diabetes May 2005, Vol.54, 1592-1597. doi:https://doi.org/10.2337/diabetes.54.5.1592

Variations in Peptide YY and Y2 Receptor Genes Are Associated With Severe Obesity in Pima Indian Men

Lijun Ma; P. Antonio Tataranni; Robert L. Hanson; Aniello M. Infante; Sayuko Kobes; Clifton Bogardus; Leslie J. Baier

Abstracts

Topics: genes , obesity , obesity, morbid , peptide yy , single nucleotide polymorphism

Diabetes May 2005, Vol.54, 1598-1602. doi:https://doi.org/10.2337/diabetes.54.5.1598

Major Histocompatibility Complex–Linked Diabetes Susceptibility in NOD/Lt Mice : Subcongenic Analysis Localizes a Component of Idd16 at the H2-D End of the Diabetogenic H2^g7 Complex

Darcy P. Pomerleau; Rebecca J. Bagley; David V. Serreze; Clayton E. Mathews; Edward H. Leiter

Abstract

Topics: alleles , alloxan , cataract , major histocompatibility complex , mice

Diabetes May 2005, Vol.54, 1603-1606. doi:https://doi.org/10.2337/diabetes.54.5.1603

The +276 Polymorphism of the APM1 Gene, Plasma Adiponectin Concentration, and Cardiovascular Risk in Diabetic Men

Lu Qi; Tricia Li; Eric Rimm; Cuilin Zhang; Nader Rifai; David Hunter; Alessandro Doria; Frank B. Hu

Abstract