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Issues
1 May 2005
ISSN 0012-1797
EISSN 1939-327X
OSA Lecture 2004
Thirty Years of Investigating the Autoimmune Basis for Type 1 Diabetes: Why Can’t We Prevent or Reverse This Disease?
Topics:
diabetes mellitus, type 1
,
autoimmunity
Diabetes May 2005, Vol.54, 1253-1263. doi:https://doi.org/10.2337/diabetes.54.5.1253
Perspectives in Diabetes
Insulin Signaling in the Central Nervous System: A Critical Role in Metabolic Homeostasis and Disease From C. elegans to Humans
Topics:
insulin
,
signal transduction
,
obesity
Diabetes May 2005, Vol.54, 1264-1276. doi:https://doi.org/10.2337/diabetes.54.5.1264
Metabolism
Glycogen Synthesis in Human Gastrocnemius Muscle Is Not Representative of Whole-Body Muscle Glycogen Synthesis
Mireille J.M. Serlie; Jacco H. de Haan; Cees J. Tack; Hein J. Verberne; Mariette T. Ackermans; Arend Heerschap; Hans P. Sauerwein
Topics:
glucose
,
glycogen synthesis
,
insulin
,
isotopes
,
gastrocnemius muscle
Diabetes May 2005, Vol.54, 1277-1282. doi:https://doi.org/10.2337/diabetes.54.5.1277
Proteome Analysis of Skeletal Muscle From Obese and Morbidly Obese Women
Topics:
obesity
,
obesity, morbid
,
skeletal muscles
,
overweight
,
gel
Diabetes May 2005, Vol.54, 1283-1288. doi:https://doi.org/10.2337/diabetes.54.5.1283
Impact of Genetic Versus Environmental Factors on the Control of Muscle Glycogen Synthase Activation in Twins
Pernille Poulsen; Jørgen F.P. Wojtaszewski; Inge Petersen; Kaare Christensen; Erik A. Richter; Henning Beck-Nielsen; Allan Vaag
Topics:
genetics
,
glycogen
,
glycogen (starch) synthase
,
glycogen synthase kinase 3
,
insulin
Diabetes May 2005, Vol.54, 1289-1296. doi:https://doi.org/10.2337/diabetes.54.5.1289
Oscillations of Fatty Acid and Glycerol Release From Human Subcutaneous Adipose Tissue In Vivo
Fredrik Karpe; Barbara A. Fielding; Simon W. Coppack; Victor J. Lawrence; Ian A. Macdonald; Keith N. Frayn
Topics:
glycerol
,
insulin
,
nonesterified fatty acids
,
norepinephrine
,
fat, subcutaneous
Diabetes May 2005, Vol.54, 1297-1303. doi:https://doi.org/10.2337/diabetes.54.5.1297
Signal Transduction
Adenovirus-Mediated Adiponectin Expression Augments Skeletal Muscle Insulin Sensitivity in Male Wistar Rats
Hiroaki Satoh; M.T. Audrey Nguyen; Maria Trujillo; Takeshi Imamura; Isao Usui; Philipp E. Scherer; Jerrold M. Olefsky
Topics:
adiponectin
,
insulin
,
rats
,
skeletal muscles
,
adenoviruses
Diabetes May 2005, Vol.54, 1304-1313. doi:https://doi.org/10.2337/diabetes.54.5.1304
Effects of Diet and Genetic Background on Sterol Regulatory Element-Binding Protein-1c, Stearoyl-CoA Desaturase 1, and the Development of the Metabolic Syndrome
Topics:
diet
,
lipids
,
mice
,
genetic background
,
stearoyl-coa desaturase
Diabetes May 2005, Vol.54, 1314-1323. doi:https://doi.org/10.2337/diabetes.54.5.1314
Parasympathetic Innervation and Function of Endocrine Pancreas Requires the Glial Cell Line–Derived Factor Family Receptor α2 (GFRα2)
Topics:
endocrine pancreas
,
mice
,
nerve supply
,
insulin
,
neuroglia
Diabetes May 2005, Vol.54, 1324-1330. doi:https://doi.org/10.2337/diabetes.54.5.1324
Short-Term Overexpression of a Constitutively Active Form of AMP-Activated Protein Kinase in the Liver Leads to Mild Hypoglycemia and Fatty Liver
Marc Foretz; Nicolas Ancellin; Fabrizio Andreelli; Yannick Saintillan; Pascal Grondin; Axel Kahn; Bernard Thorens; Sophie Vaulont; Benoît Viollet
Topics:
ampk
,
fatty liver
,
glucose
,
hypoglycemia
,
liver
Diabetes May 2005, Vol.54, 1331-1339. doi:https://doi.org/10.2337/diabetes.54.5.1331
A Role for iNOS in Fasting Hyperglycemia and Impaired Insulin Signaling in the Liver of Obese Diabetic Mice
Topics:
insulin
,
liver
,
mice
,
nitric oxide synthase
,
irs1 protein, human
Diabetes May 2005, Vol.54, 1340-1348. doi:https://doi.org/10.2337/diabetes.54.5.1340
Akt2 Is Essential for the Full Effect of Calorie Restriction on Insulin-Stimulated Glucose Uptake in Skeletal Muscle
Topics:
calorie restricted diet
,
insulin
,
mice
,
phosphorylation
,
serine
Diabetes May 2005, Vol.54, 1349-1356. doi:https://doi.org/10.2337/diabetes.54.5.1349
Essential Role of Chicken Ovalbumin Upstream Promoter-Transcription Factor II in Insulin Secretion and Insulin Sensitivity Revealed by Conditional Gene Knockout
Pascale Bardoux; Pili Zhang; Daisy Flamez; Anaïs Perilhou; Tiphaine Aguirre Lavin; Jean-François Tanti; Karine Hellemans; Emmanuel Gomas; Cécile Godard; Fabrizio Andreelli; Maria Antonietta Buccheri; Axel Kahn; Yannick Le Marchand-Brustel; Rémy Burcelin; Frans Schuit; Mireille Vasseur-Cognet
Topics:
glucose
,
insulin
,
insulin secretion
,
mice
,
insulin sensitivity
Diabetes May 2005, Vol.54, 1357-1363. doi:https://doi.org/10.2337/diabetes.54.5.1357
Obesity Studies
The Contribution of Visceral Adipose Tissue to Splanchnic Cortisol Production in Healthy Humans
Topics:
cortisone
,
hydrocortisone
,
steady state
,
visceral fat
Diabetes May 2005, Vol.54, 1364-1370. doi:https://doi.org/10.2337/diabetes.54.5.1364
Differential Association of Basal and Postprandial Plasma Ghrelin With Leptin, Insulin, and Type 2 Diabetes
Topics:
ghrelin
,
insulin
,
leptin
,
obesity
,
postprandial period
Diabetes May 2005, Vol.54, 1371-1378. doi:https://doi.org/10.2337/diabetes.54.5.1371
Rosiglitazone Increases Indexes of Stearoyl-CoA Desaturase Activity in Humans: Link to Insulin Sensitization and the Role of Dominant-Negative Mutation in Peroxisome Proliferator-Activated Receptor-γ
Ulf Risérus; Garry D. Tan; Barbara A. Fielding; Matt J. Neville; Jenny Currie; David B. Savage; V. Krishna Chatterjee; Keith N. Frayn; Stephen O’Rahilly; Fredrik Karpe
Topics:
fatty acids
,
insulin
,
insulin sensitivity
,
rosiglitazone
,
peroxisome
Diabetes May 2005, Vol.54, 1379-1384. doi:https://doi.org/10.2337/diabetes.54.5.1379
Uncoupling Protein 1 Is Necessary for Norepinephrine-Induced Glucose Utilization in Brown Adipose Tissue
Ken-ichi Inokuma; Yuko Ogura-Okamatsu; Chitoku Toda; Kazuhiro Kimura; Hitoshi Yamashita; Masayuki Saito
Topics:
adenylate kinase
,
brown fat
,
glucose
,
insulin
,
mice
Diabetes May 2005, Vol.54, 1385-1391. doi:https://doi.org/10.2337/diabetes.54.5.1385
Pioglitazone Induces Mitochondrial Biogenesis in Human Subcutaneous Adipose Tissue In Vivo
Topics:
dna, mitochondrial
,
mitochondria
,
peroxisome proliferator-activated receptors
,
pioglitazone
,
origin of life
Diabetes May 2005, Vol.54, 1392-1399. doi:https://doi.org/10.2337/diabetes.54.5.1392
Immunology and Transplantation
Donor Treatment With Carbon Monoxide Can Yield Islet Allograft Survival and Tolerance
Hongjun Wang; Soo Sun Lee; Wenda Gao; Eva Czismadia; James McDaid; Robert Öllinger; Miguel P. Soares; Kenichiro Yamashita; Fritz H. Bach
Topics:
cytokine
,
donors
,
reverse transcriptase polymerase chain reaction
,
tissue transplants
,
transplantation
Diabetes May 2005, Vol.54, 1400-1406. doi:https://doi.org/10.2337/diabetes.54.5.1400
Functional Defects and the Influence of Age on the Frequency of CD4+CD25+ T-Cells in Type 1 Diabetes
Topics:
antigens, cd25
,
diabetes mellitus, type 1
,
t-lymphocytes
,
regulatory t-lymphocytes
,
cytokine
Diabetes May 2005, Vol.54, 1407-1414. doi:https://doi.org/10.2337/diabetes.54.5.1407
Autoimmune Diabetes Onset Results From Qualitative Rather Than Quantitative Age-Dependent Changes in Pathogenic T-Cells
Sylvaine You; Mériam Belghith; Stephen Cobbold; Marie-Alexandra Alyanakian; Christine Gouarin; Samia Barriot; Corinne Garcia; Herman Waldmann; Jean-François Bach; Lucienne Chatenoud
Topics:
antigens, cd25
,
mice
,
mice, inbred nod
,
t-lymphocytes
,
regulatory t-lymphocytes
Diabetes May 2005, Vol.54, 1415-1422. doi:https://doi.org/10.2337/diabetes.54.5.1415
Tumor Suppressor p53 Inhibits Autoimmune Inflammation and Macrophage Function
Topics:
cytokine
,
inflammation
,
macrophages
,
mice
,
protein p53
Diabetes May 2005, Vol.54, 1423-1428. doi:https://doi.org/10.2337/diabetes.54.5.1423
Islet Studies
Sphingosine Kinase Activity and Sphingosine-1 Phosphate Production in Rat Pancreatic Islets and INS-1 Cells: Response to Cytokines
Topics:
cytokine
,
phosphates
,
phosphotransferases
,
rna, messenger
,
sphingosine
Diabetes May 2005, Vol.54, 1429-1436. doi:https://doi.org/10.2337/diabetes.54.5.1429
MnSOD and Catalase Transgenes Demonstrate That Protection of Islets From Oxidative Stress Does Not Alter Cytokine Toxicity
Topics:
catalase
,
cytokine
,
toxic effect
,
transgenes
,
antioxidants
Diabetes May 2005, Vol.54, 1437-1446. doi:https://doi.org/10.2337/diabetes.54.5.1437
Pathophysiology
Insulin Signaling in the Central Nervous System Is Critical for the Normal Sympathoadrenal Response to Hypoglycemia
Topics:
central nervous system
,
glucose
,
hypoglycemia
,
insulin
,
mice
Diabetes May 2005, Vol.54, 1447-1451. doi:https://doi.org/10.2337/diabetes.54.5.1447
Pyruvate Administered After Severe Hypoglycemia Reduces Neuronal Death and Cognitive Impairment
Topics:
hypoglycemia
,
pyruvates
,
glucose
,
brain
Diabetes May 2005, Vol.54, 1452-1458. doi:https://doi.org/10.2337/diabetes.54.5.1452
Effects of Metformin and Rosiglitazone Treatment on Insulin Signaling and Glucose Uptake in Patients With Newly Diagnosed Type 2 Diabetes: A Randomized Controlled Study
Håkan K.R. Karlsson; Kirsti Hällsten; Marie Björnholm; Hiroki Tsuchida; Alexander V. Chibalin; Kirsi A. Virtanen; Olli J. Heinonen; Fredrik Lönnqvist; Pirjo Nuutila; Juleen R. Zierath
Topics:
1-phosphatidylinositol 3-kinase
,
diabetes mellitus, type 2
,
glucose uptake
,
insulin
,
irs1 protein, human
Diabetes May 2005, Vol.54, 1459-1467. doi:https://doi.org/10.2337/diabetes.54.5.1459
Demonstration of a Hyperglycemia-Driven Pathogenic Abnormality of Copper Homeostasis in Diabetes and Its Reversibility by Selective Chelation: Quantitative Comparisons Between the Biology of Copper and Eight Other Nutritionally Essential Elements in Normal and Diabetic Individuals
Garth J.S. Cooper; Yih-Kai Chan; Ajith M. Dissanayake; Fiona E. Leahy; Geraldine F. Keogh; Chris M. Frampton; Gregory D. Gamble; Dianne H. Brunton; John R. Baker; Sally D. Poppitt
Topics:
excretory function
,
trientine
,
urinary tract
,
hemoglobin a, glycosylated
,
copper
Diabetes May 2005, Vol.54, 1468-1476. doi:https://doi.org/10.2337/diabetes.54.5.1468
Complications
G(−) Anaerobes–Reactive CD4+ T-Cells Trigger RANKL-Mediated Enhanced Alveolar Bone Loss in Diabetic NOD Mice
Deeqa A. Mahamed; Annette Marleau; Mawadda Alnaeeli; Bhagirath Singh; Xiaoxia Zhang; Joseph M. Penninger; Yen-Tung A. Teng
Topics:
alveolar bone loss
,
mice
,
mice, inbred nod
,
prediabetes
,
t-lymphocytes
Diabetes May 2005, Vol.54, 1477-1486. doi:https://doi.org/10.2337/diabetes.54.5.1477
Nonproteinuric Diabetes-Associated Nephropathy in the Cohen Rat Model of Type 2 Diabetes
Chana Yagil; Adiel Barak; David Ben-Dor; Eliezer Rosenmann; Joel Bernheim; Mordechai Rosner; Yael Segev; Sarah Weksler-Zangen; Itamar Raz; Yoram Yagil
Topics:
calmodulin
,
chanarin-dorfman disease
,
clinical dementia rating scale
,
complementarity determining regions
,
creatinine clearance
Diabetes May 2005, Vol.54, 1487-1496. doi:https://doi.org/10.2337/diabetes.54.5.1487
The Effect of C-Peptide on Cognitive Dysfunction and Hippocampal Apoptosis in Type 1 Diabetic Rats
Topics:
c-peptide
,
rats
,
hippocampus
,
apoptosis
Diabetes May 2005, Vol.54, 1497-1505. doi:https://doi.org/10.2337/diabetes.54.5.1497
Linoleic Acid Increases Lectin-Like Oxidized LDL Receptor-1 (LOX-1) Expression in Human Aortic Endothelial Cells
Topics:
actins
,
aorta
,
endothelial cells
,
endothelium
,
genes
Diabetes May 2005, Vol.54, 1506-1513. doi:https://doi.org/10.2337/diabetes.54.5.1506
Low-Dose Poly(ADP-Ribose) Polymerase Inhibitor-Containing Combination Therapies Reverse Early Peripheral Diabetic Neuropathy
Topics:
adenosine diphosphate ribose
,
diabetic neuropathies
,
international organization for standardization
,
poly(adp-ribose) polymerases
,
rats
Diabetes May 2005, Vol.54, 1514-1522. doi:https://doi.org/10.2337/diabetes.54.5.1514
Mannose-Binding Lectin as a Predictor of Microalbuminuria in Type 1 Diabetes: An Inception Cohort Study
Peter Hovind; Troels Krarup Hansen; Lise Tarnow; Steffen Thiel; Rudi Steffensen; Allan Flyvbjerg; Hans-Henrik Parving
Topics:
diabetes mellitus, type 1
,
mannose binding lectin
,
microalbuminuria
,
microbiology procedures
,
complement system proteins
Diabetes May 2005, Vol.54, 1523-1527. doi:https://doi.org/10.2337/diabetes.54.5.1523
Reduced Insulin and IGF-I Signaling, not Hyperglycemia, Underlies the Diabetes-Associated Depletion of Interstitial Cells of Cajal in the Murine Stomach
Topics:
hyperglycemia
,
insulin
,
insulin-like growth factor i
,
interstitial cells of cajal
,
mice
Diabetes May 2005, Vol.54, 1528-1533. doi:https://doi.org/10.2337/diabetes.54.5.1528
Neutrophils Are Associated With Capillary Closure in Spontaneously Diabetic Monkey Retinas
Sahng Y. Kim; Mary A. Johnson; D. Scott McLeod; Theresa Alexander; Barbara C. Hansen; Gerard A. Lutty
Topics:
apyrase
,
blood capillaries
,
cercopithecidae
,
neutrophils
,
retina
Diabetes May 2005, Vol.54, 1534-1542. doi:https://doi.org/10.2337/diabetes.54.5.1534
Wound Inflammation in Diabetic ob/ob Mice : Functional Coupling of Prostaglandin Biosynthesis to Cyclooxygenase-1 Activity in Diabetes-Impaired Wound Healing
Topics:
biosynthesis
,
cyclooxygenase-1
,
cyclooxygenase-2
,
inflammation
,
leptin
Diabetes May 2005, Vol.54, 1543-1551. doi:https://doi.org/10.2337/diabetes.54.5.1543
Pharmacology and Therapeutics
Inhibitory Effects of Antipsychotics on Carbachol-Enhanced Insulin Secretion From Perifused Rat Islets: Role of Muscarinic Antagonism in Antipsychotic-Induced Diabetes and Hyperglycemia
David E. Johnson; Hanae Yamazaki; Karen M. Ward; Anne W. Schmidt; Wesley S. Lebel; Judith L. Treadway; E. Michael Gibbs; Walter S. Zawalich; Hans Rollema
Topics:
antagonists
,
antipsychotic agents
,
carbachol
,
clozapine
,
glucose
Diabetes May 2005, Vol.54, 1552-1558. doi:https://doi.org/10.2337/diabetes.54.5.1552
Minocycline Reduces Proinflammatory Cytokine Expression, Microglial Activation, and Caspase-3 Activation in a Rodent Model of Diabetic Retinopathy
J. Kyle Krady; Anirban Basu; Colleen M. Allen; Yuping Xu; Kathryn F. LaNoue; Thomas W. Gardner; Steven W. Levison
Topics:
caspase-3
,
cytokine
,
diabetic retinopathy
,
microglia
,
minocycline
Diabetes May 2005, Vol.54, 1559-1565. doi:https://doi.org/10.2337/diabetes.54.5.1559
Intensive Lifestyle Intervention or Metformin on Inflammation and Coagulation in Participants With Impaired Glucose Tolerance
Topics:
c-reactive protein
,
fibrinogen
,
glucose intolerance
,
inflammation
,
insulin resistance
Diabetes May 2005, Vol.54, 1566-1572. doi:https://doi.org/10.2337/diabetes.54.5.1566
Kallikrein Gene Delivery Improves Serum Glucose and Lipid Profiles and Cardiac Function in Streptozotocin-Induced Diabetic Rats
Topics:
genes
,
kininogenase
,
rats
,
streptozocin
,
tissue kallikrein
Diabetes May 2005, Vol.54, 1573-1580. doi:https://doi.org/10.2337/diabetes.54.5.1573
Genetics
Subcellular Localization of ALMS1 Supports Involvement of Centrosome and Basal Body Dysfunction in the Pathogenesis of Obesity, Insulin Resistance, and Type 2 Diabetes
Tom Hearn; Cosma Spalluto; Victoria J. Phillips; Glenn L. Renforth; Nane Copin; Neil A. Hanley; David I. Wilson
Topics:
alstrom syndrome
,
antibodies
,
centrosome
,
cilia
,
diabetes mellitus, type 2
Diabetes May 2005, Vol.54, 1581-1587. doi:https://doi.org/10.2337/diabetes.54.5.1581
Brief Genetics Reports
OAS1 Splice Site Polymorphism Controlling Antiviral Enzyme Activity Influences Susceptibility to Type 1 Diabetes
L. Leigh Field; Vagn Bonnevie-Nielsen; Flemming Pociot; Shao Lu; Thomas B. Nielsen; Henning Beck-Nielsen
Topics:
antiviral agents
,
diabetes mellitus, type 1
,
enzyme activity
,
genotype
,
polymorphism
Diabetes May 2005, Vol.54, 1588-1591. doi:https://doi.org/10.2337/diabetes.54.5.1588
Single Nucleotide Polymorphisms in KATP Channels: Muscular Impact on Type 2 Diabetes
Diabetes May 2005, Vol.54, 1592-1597. doi:https://doi.org/10.2337/diabetes.54.5.1592
Variations in Peptide YY and Y2 Receptor Genes Are Associated With Severe Obesity in Pima Indian Men
Lijun Ma; P. Antonio Tataranni; Robert L. Hanson; Aniello M. Infante; Sayuko Kobes; Clifton Bogardus; Leslie J. Baier
Topics:
genes
,
obesity
,
obesity, morbid
,
peptide yy
,
single nucleotide polymorphism
Diabetes May 2005, Vol.54, 1598-1602. doi:https://doi.org/10.2337/diabetes.54.5.1598
Major Histocompatibility Complex–Linked Diabetes Susceptibility in NOD/Lt Mice : Subcongenic Analysis Localizes a Component of Idd16 at the H2-D End of the Diabetogenic H2g7 Complex
Topics:
alleles
,
alloxan
,
cataract
,
major histocompatibility complex
,
mice
Diabetes May 2005, Vol.54, 1603-1606. doi:https://doi.org/10.2337/diabetes.54.5.1603
The +276 Polymorphism of the APM1 Gene, Plasma Adiponectin Concentration, and Cardiovascular Risk in Diabetic Men
Topics:
adiponectin
,
cardiovascular diseases
,
heart disease risk factors
,
plasma
,
genes
Diabetes May 2005, Vol.54, 1607-1610. doi:https://doi.org/10.2337/diabetes.54.5.1607