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Issues
1 May 2005
ISSN 0012-1797
EISSN 1939-327X
OSA Lecture 2004
Thirty Years of Investigating the Autoimmune Basis for Type 1 Diabetes: Why Can’t We Prevent or Reverse This Disease?
Diabetes May 2005, Vol.54, 1253-1263. doi:https://doi.org/10.2337/diabetes.54.5.1253
Perspectives in Diabetes
Insulin Signaling in the Central Nervous System: A Critical Role in Metabolic Homeostasis and Disease From C. elegans to Humans
Diabetes May 2005, Vol.54, 1264-1276. doi:https://doi.org/10.2337/diabetes.54.5.1264
Metabolism
Glycogen Synthesis in Human Gastrocnemius Muscle Is Not Representative of Whole-Body Muscle Glycogen Synthesis
Mireille J.M. Serlie; Jacco H. de Haan; Cees J. Tack; Hein J. Verberne; Mariette T. Ackermans; Arend Heerschap; Hans P. Sauerwein
Diabetes May 2005, Vol.54, 1277-1282. doi:https://doi.org/10.2337/diabetes.54.5.1277
Proteome Analysis of Skeletal Muscle From Obese and Morbidly Obese Women
Diabetes May 2005, Vol.54, 1283-1288. doi:https://doi.org/10.2337/diabetes.54.5.1283
Impact of Genetic Versus Environmental Factors on the Control of Muscle Glycogen Synthase Activation in Twins
Pernille Poulsen; Jørgen F.P. Wojtaszewski; Inge Petersen; Kaare Christensen; Erik A. Richter; Henning Beck-Nielsen; Allan Vaag
Diabetes May 2005, Vol.54, 1289-1296. doi:https://doi.org/10.2337/diabetes.54.5.1289
Signal Transduction
Adenovirus-Mediated Adiponectin Expression Augments Skeletal Muscle Insulin Sensitivity in Male Wistar Rats
Hiroaki Satoh; M.T. Audrey Nguyen; Maria Trujillo; Takeshi Imamura; Isao Usui; Philipp E. Scherer; Jerrold M. Olefsky
Diabetes May 2005, Vol.54, 1304-1313. doi:https://doi.org/10.2337/diabetes.54.5.1304
Short-Term Overexpression of a Constitutively Active Form of AMP-Activated Protein Kinase in the Liver Leads to Mild Hypoglycemia and Fatty Liver
Marc Foretz; Nicolas Ancellin; Fabrizio Andreelli; Yannick Saintillan; Pascal Grondin; Axel Kahn; Bernard Thorens; Sophie Vaulont; Benoît Viollet
Diabetes May 2005, Vol.54, 1331-1339. doi:https://doi.org/10.2337/diabetes.54.5.1331
A Role for iNOS in Fasting Hyperglycemia and Impaired Insulin Signaling in the Liver of Obese Diabetic Mice
Diabetes May 2005, Vol.54, 1340-1348. doi:https://doi.org/10.2337/diabetes.54.5.1340
Akt2 Is Essential for the Full Effect of Calorie Restriction on Insulin-Stimulated Glucose Uptake in Skeletal Muscle
Diabetes May 2005, Vol.54, 1349-1356. doi:https://doi.org/10.2337/diabetes.54.5.1349
Essential Role of Chicken Ovalbumin Upstream Promoter-Transcription Factor II in Insulin Secretion and Insulin Sensitivity Revealed by Conditional Gene Knockout
Pascale Bardoux; Pili Zhang; Daisy Flamez; Anaïs Perilhou; Tiphaine Aguirre Lavin; Jean-François Tanti; Karine Hellemans; Emmanuel Gomas; Cécile Godard; Fabrizio Andreelli; Maria Antonietta Buccheri; Axel Kahn; Yannick Le Marchand-Brustel; Rémy Burcelin; Frans Schuit; Mireille Vasseur-Cognet
Diabetes May 2005, Vol.54, 1357-1363. doi:https://doi.org/10.2337/diabetes.54.5.1357
Obesity Studies
The Contribution of Visceral Adipose Tissue to Splanchnic Cortisol Production in Healthy Humans
Diabetes May 2005, Vol.54, 1364-1370. doi:https://doi.org/10.2337/diabetes.54.5.1364
Differential Association of Basal and Postprandial Plasma Ghrelin With Leptin, Insulin, and Type 2 Diabetes
Diabetes May 2005, Vol.54, 1371-1378. doi:https://doi.org/10.2337/diabetes.54.5.1371
Rosiglitazone Increases Indexes of Stearoyl-CoA Desaturase Activity in Humans: Link to Insulin Sensitization and the Role of Dominant-Negative Mutation in Peroxisome Proliferator-Activated Receptor-γ
Ulf Risérus; Garry D. Tan; Barbara A. Fielding; Matt J. Neville; Jenny Currie; David B. Savage; V. Krishna Chatterjee; Keith N. Frayn; Stephen O’Rahilly; Fredrik Karpe
Diabetes May 2005, Vol.54, 1379-1384. doi:https://doi.org/10.2337/diabetes.54.5.1379
Pioglitazone Induces Mitochondrial Biogenesis in Human Subcutaneous Adipose Tissue In Vivo
Diabetes May 2005, Vol.54, 1392-1399. doi:https://doi.org/10.2337/diabetes.54.5.1392
Immunology and Transplantation
Donor Treatment With Carbon Monoxide Can Yield Islet Allograft Survival and Tolerance
Hongjun Wang; Soo Sun Lee; Wenda Gao; Eva Czismadia; James McDaid; Robert Öllinger; Miguel P. Soares; Kenichiro Yamashita; Fritz H. Bach
Diabetes May 2005, Vol.54, 1400-1406. doi:https://doi.org/10.2337/diabetes.54.5.1400
Functional Defects and the Influence of Age on the Frequency of CD4+CD25+ T-Cells in Type 1 Diabetes
Diabetes May 2005, Vol.54, 1407-1414. doi:https://doi.org/10.2337/diabetes.54.5.1407
Autoimmune Diabetes Onset Results From Qualitative Rather Than Quantitative Age-Dependent Changes in Pathogenic T-Cells
Sylvaine You; Mériam Belghith; Stephen Cobbold; Marie-Alexandra Alyanakian; Christine Gouarin; Samia Barriot; Corinne Garcia; Herman Waldmann; Jean-François Bach; Lucienne Chatenoud
Diabetes May 2005, Vol.54, 1415-1422. doi:https://doi.org/10.2337/diabetes.54.5.1415
Tumor Suppressor p53 Inhibits Autoimmune Inflammation and Macrophage Function
Diabetes May 2005, Vol.54, 1423-1428. doi:https://doi.org/10.2337/diabetes.54.5.1423
Islet Studies
Sphingosine Kinase Activity and Sphingosine-1 Phosphate Production in Rat Pancreatic Islets and INS-1 Cells: Response to Cytokines
Diabetes May 2005, Vol.54, 1429-1436. doi:https://doi.org/10.2337/diabetes.54.5.1429
MnSOD and Catalase Transgenes Demonstrate That Protection of Islets From Oxidative Stress Does Not Alter Cytokine Toxicity
Diabetes May 2005, Vol.54, 1437-1446. doi:https://doi.org/10.2337/diabetes.54.5.1437
Pathophysiology
Insulin Signaling in the Central Nervous System Is Critical for the Normal Sympathoadrenal Response to Hypoglycemia
Diabetes May 2005, Vol.54, 1447-1451. doi:https://doi.org/10.2337/diabetes.54.5.1447
Pyruvate Administered After Severe Hypoglycemia Reduces Neuronal Death and Cognitive Impairment
Diabetes May 2005, Vol.54, 1452-1458. doi:https://doi.org/10.2337/diabetes.54.5.1452
Effects of Metformin and Rosiglitazone Treatment on Insulin Signaling and Glucose Uptake in Patients With Newly Diagnosed Type 2 Diabetes: A Randomized Controlled Study
Håkan K.R. Karlsson; Kirsti Hällsten; Marie Björnholm; Hiroki Tsuchida; Alexander V. Chibalin; Kirsi A. Virtanen; Olli J. Heinonen; Fredrik Lönnqvist; Pirjo Nuutila; Juleen R. Zierath
Diabetes May 2005, Vol.54, 1459-1467. doi:https://doi.org/10.2337/diabetes.54.5.1459
Demonstration of a Hyperglycemia-Driven Pathogenic Abnormality of Copper Homeostasis in Diabetes and Its Reversibility by Selective Chelation: Quantitative Comparisons Between the Biology of Copper and Eight Other Nutritionally Essential Elements in Normal and Diabetic Individuals
Garth J.S. Cooper; Yih-Kai Chan; Ajith M. Dissanayake; Fiona E. Leahy; Geraldine F. Keogh; Chris M. Frampton; Gregory D. Gamble; Dianne H. Brunton; John R. Baker; Sally D. Poppitt
Diabetes May 2005, Vol.54, 1468-1476. doi:https://doi.org/10.2337/diabetes.54.5.1468
Complications
G(−) Anaerobes–Reactive CD4+ T-Cells Trigger RANKL-Mediated Enhanced Alveolar Bone Loss in Diabetic NOD Mice
Deeqa A. Mahamed; Annette Marleau; Mawadda Alnaeeli; Bhagirath Singh; Xiaoxia Zhang; Joseph M. Penninger; Yen-Tung A. Teng
Diabetes May 2005, Vol.54, 1477-1486. doi:https://doi.org/10.2337/diabetes.54.5.1477
Nonproteinuric Diabetes-Associated Nephropathy in the Cohen Rat Model of Type 2 Diabetes
Chana Yagil; Adiel Barak; David Ben-Dor; Eliezer Rosenmann; Joel Bernheim; Mordechai Rosner; Yael Segev; Sarah Weksler-Zangen; Itamar Raz; Yoram Yagil
Diabetes May 2005, Vol.54, 1487-1496. doi:https://doi.org/10.2337/diabetes.54.5.1487
The Effect of C-Peptide on Cognitive Dysfunction and Hippocampal Apoptosis in Type 1 Diabetic Rats
Diabetes May 2005, Vol.54, 1497-1505. doi:https://doi.org/10.2337/diabetes.54.5.1497
Linoleic Acid Increases Lectin-Like Oxidized LDL Receptor-1 (LOX-1) Expression in Human Aortic Endothelial Cells
Diabetes May 2005, Vol.54, 1506-1513. doi:https://doi.org/10.2337/diabetes.54.5.1506
Low-Dose Poly(ADP-Ribose) Polymerase Inhibitor-Containing Combination Therapies Reverse Early Peripheral Diabetic Neuropathy
Diabetes May 2005, Vol.54, 1514-1522. doi:https://doi.org/10.2337/diabetes.54.5.1514
Mannose-Binding Lectin as a Predictor of Microalbuminuria in Type 1 Diabetes: An Inception Cohort Study
Peter Hovind; Troels Krarup Hansen; Lise Tarnow; Steffen Thiel; Rudi Steffensen; Allan Flyvbjerg; Hans-Henrik Parving
Diabetes May 2005, Vol.54, 1523-1527. doi:https://doi.org/10.2337/diabetes.54.5.1523
Pharmacology and Therapeutics
Inhibitory Effects of Antipsychotics on Carbachol-Enhanced Insulin Secretion From Perifused Rat Islets: Role of Muscarinic Antagonism in Antipsychotic-Induced Diabetes and Hyperglycemia
David E. Johnson; Hanae Yamazaki; Karen M. Ward; Anne W. Schmidt; Wesley S. Lebel; Judith L. Treadway; E. Michael Gibbs; Walter S. Zawalich; Hans Rollema
Diabetes May 2005, Vol.54, 1552-1558. doi:https://doi.org/10.2337/diabetes.54.5.1552
Minocycline Reduces Proinflammatory Cytokine Expression, Microglial Activation, and Caspase-3 Activation in a Rodent Model of Diabetic Retinopathy
J. Kyle Krady; Anirban Basu; Colleen M. Allen; Yuping Xu; Kathryn F. LaNoue; Thomas W. Gardner; Steven W. Levison
Diabetes May 2005, Vol.54, 1559-1565. doi:https://doi.org/10.2337/diabetes.54.5.1559
Intensive Lifestyle Intervention or Metformin on Inflammation and Coagulation in Participants With Impaired Glucose Tolerance
Diabetes May 2005, Vol.54, 1566-1572. doi:https://doi.org/10.2337/diabetes.54.5.1566
Kallikrein Gene Delivery Improves Serum Glucose and Lipid Profiles and Cardiac Function in Streptozotocin-Induced Diabetic Rats
Diabetes May 2005, Vol.54, 1573-1580. doi:https://doi.org/10.2337/diabetes.54.5.1573
Genetics
Subcellular Localization of ALMS1 Supports Involvement of Centrosome and Basal Body Dysfunction in the Pathogenesis of Obesity, Insulin Resistance, and Type 2 Diabetes
Tom Hearn; Cosma Spalluto; Victoria J. Phillips; Glenn L. Renforth; Nane Copin; Neil A. Hanley; David I. Wilson
Diabetes May 2005, Vol.54, 1581-1587. doi:https://doi.org/10.2337/diabetes.54.5.1581
Brief Genetics Reports
OAS1 Splice Site Polymorphism Controlling Antiviral Enzyme Activity Influences Susceptibility to Type 1 Diabetes
L. Leigh Field; Vagn Bonnevie-Nielsen; Flemming Pociot; Shao Lu; Thomas B. Nielsen; Henning Beck-Nielsen
Diabetes May 2005, Vol.54, 1588-1591. doi:https://doi.org/10.2337/diabetes.54.5.1588
Single Nucleotide Polymorphisms in KATP Channels: Muscular Impact on Type 2 Diabetes
Diabetes May 2005, Vol.54, 1592-1597. doi:https://doi.org/10.2337/diabetes.54.5.1592
Variations in Peptide YY and Y2 Receptor Genes Are Associated With Severe Obesity in Pima Indian Men
Lijun Ma; P. Antonio Tataranni; Robert L. Hanson; Aniello M. Infante; Sayuko Kobes; Clifton Bogardus; Leslie J. Baier
Diabetes May 2005, Vol.54, 1598-1602. doi:https://doi.org/10.2337/diabetes.54.5.1598
The +276 Polymorphism of the APM1 Gene, Plasma Adiponectin Concentration, and Cardiovascular Risk in Diabetic Men
Diabetes May 2005, Vol.54, 1607-1610. doi:https://doi.org/10.2337/diabetes.54.5.1607