Skip Nav Destination
Issues
Banting Lecture 2004
The Pathobiology of Diabetic Complications: A Unifying Mechanism
Diabetes June 2005, Vol.54, 1615-1625. doi:https://doi.org/10.2337/diabetes.54.6.1615
Perspectives in Diabetes
Metabolism
Continuous Glucose Monitoring in Interstitial Subcutaneous Adipose Tissue and Skeletal Muscle Reflects Excursions in Cerebral Cortex
Jannik Kruse Nielsen; Christian Born Djurhuus; Claus Højbjerg Gravholt; Andreas Christiansen Carus; Jacob Granild-Jensen; Hans Ørskov; Jens Sandahl Christiansen
Diabetes June 2005, Vol.54, 1635-1639. doi:https://doi.org/10.2337/diabetes.54.6.1635
Dose-Response Effect of Elevated Plasma Free Fatty Acid on Insulin Signaling
Renata Belfort; Lawrence Mandarino; Sangeeta Kashyap; Kelly Wirfel; Thongchai Pratipanawatr; Rachele Berria; Ralph A. DeFronzo; Kenneth Cusi
Diabetes June 2005, Vol.54, 1640-1648. doi:https://doi.org/10.2337/diabetes.54.6.1640
Pulsatile Insulin Secretion Dictates Systemic Insulin Delivery by Regulating Hepatic Insulin Extraction In Humans
Diabetes June 2005, Vol.54, 1649-1656. doi:https://doi.org/10.2337/diabetes.54.6.1649
Adipocyte-Specific Overexpression of FOXC2 Prevents Diet-Induced Increases in Intramuscular Fatty Acyl CoA and Insulin Resistance
Jason K. Kim; Hyo-Jeong Kim; So-Young Park; Anna Cederberg; Rickard Westergren; Daniel Nilsson; Takamasa Higashimori; You-Ree Cho; Zhen-Xiang Liu; Jianying Dong; Gary W. Cline; Sven Enerback; Gerald I. Shulman
Diabetes June 2005, Vol.54, 1657-1663. doi:https://doi.org/10.2337/diabetes.54.6.1657
Signal Transduction
Gene Transfer of Constitutively Active Akt Markedly Improves Human Islet Transplant Outcomes in Diabetic Severe Combined Immunodeficient Mice
Poornima Rao; Jennifer Roccisana; Karen K. Takane; Rita Bottino; Allan Zhao; Massimo Trucco; Adolfo García-Ocaña
Diabetes June 2005, Vol.54, 1664-1675. doi:https://doi.org/10.2337/diabetes.54.6.1664
Inhibition of Microsomal Triglyceride Transfer Protein Expression and Apolipoprotein B100 Secretion by the Citrus Flavonoid Naringenin and by Insulin Involves Activation of the Mitogen-Activated Protein Kinase Pathway in Hepatocytes
Diabetes June 2005, Vol.54, 1676-1683. doi:https://doi.org/10.2337/diabetes.54.6.1676
Glucose-Stimulated Upregulation of GLUT2 Gene Is Mediated by Sterol Response Element–Binding Protein-1c in the Hepatocytes
Diabetes June 2005, Vol.54, 1684-1691. doi:https://doi.org/10.2337/diabetes.54.6.1684
Insulin-Stimulated Phosphorylation of the Akt Substrate AS160 Is Impaired in Skeletal Muscle of Type 2 Diabetic Subjects
Håkan K.R. Karlsson; Juleen R. Zierath; Susan Kane; Anna Krook; Gustav E. Lienhard; Harriet Wallberg-Henriksson
Diabetes June 2005, Vol.54, 1692-1697. doi:https://doi.org/10.2337/diabetes.54.6.1692
Phosphatidylinositol 4,5-Bisphosphate Reverses Endothelin-1–Induced Insulin Resistance via an Actin-Dependent Mechanism
Diabetes June 2005, Vol.54, 1698-1705. doi:https://doi.org/10.2337/diabetes.54.6.1698
Obesity Studies
The Link Between Nutritional Status and Insulin Sensitivity Is Dependent on the Adipocyte-Specific Peroxisome Proliferator–Activated Receptor-γ2 Isoform
Gema Medina-Gomez; Sam Virtue; Christopher Lelliott; Romina Boiani; Mark Campbell; Constantinos Christodoulides; Christophe Perrin; Mercedes Jimenez-Linan; Margaret Blount; John Dixon; Dirk Zahn; Rosemary R. Thresher; Sam Aparicio; Mark Carlton; William H. Colledge; Mikko I. Kettunen; Tuulikki Seppänen-Laakso; Jaswinder K. Sethi; Stephen O’Rahilly; Kevin Brindle; Saverio Cinti; Matej Orešič; Remy Burcelin; Antonio Vidal-Puig
Diabetes June 2005, Vol.54, 1706-1716. doi:https://doi.org/10.2337/diabetes.54.6.1706
Insulin and Leptin Resistance With Hyperleptinemia in Mice Lacking Androgen Receptor
Diabetes June 2005, Vol.54, 1717-1725. doi:https://doi.org/10.2337/diabetes.54.6.1717
A Human-Specific Role of Cell Death-Inducing DFFA (DNA Fragmentation Factor-α)-Like Effector A (CIDEA) in Adipocyte Lipolysis and Obesity
Elisabet Arvidsson Nordström; Mikael Rydén; Emma C. Backlund; Ingrid Dahlman; Maria Kaaman; Lennart Blomqvist; Barbara Cannon; Jan Nedergaard; Peter Arner
Diabetes June 2005, Vol.54, 1726-1734. doi:https://doi.org/10.2337/diabetes.54.6.1726
β-Cell Function Across the Spectrum of Glucose Tolerance in Obese Youth
Ram Weiss; Sonia Caprio; Maddalena Trombetta; Sara E. Taksali; William V. Tamborlane; Riccardo Bonadonna
Diabetes June 2005, Vol.54, 1735-1743. doi:https://doi.org/10.2337/diabetes.54.6.1735
C/EBPα Regulates Human Adiponectin Gene Transcription Through an Intronic Enhancer
Liping Qiao; Paul S. MacLean; Jerome Schaack; David J. Orlicky; Christian Darimont; Michael Pagliassotti; Jacob E. Friedman; Jianhua Shao
Diabetes June 2005, Vol.54, 1744-1754. doi:https://doi.org/10.2337/diabetes.54.6.1744
Immunology and Transplantation
Tissue Factor Produced by the Endocrine Cells of the Islets of Langerhans Is Associated With a Negative Outcome of Clinical Islet Transplantation
Helena Johansson; Agneta Lukinius; Lisa Moberg; Torbjörn Lundgren; Christian Berne; Aksel Foss; Marie Felldin; Ragnar Källen; Kaija Salmela; Annika Tibell; Gunnar Tufveson; Kristina Nilsson Ekdahl; Graciela Elgue; Olle Korsgren; Bo Nilsson
Diabetes June 2005, Vol.54, 1755-1762. doi:https://doi.org/10.2337/diabetes.54.6.1755
A Single Course of Anti-CD3 Monoclonal Antibody hOKT3γ1(Ala-Ala) Results in Improvement in C-Peptide Responses and Clinical Parameters for at Least 2 Years after Onset of Type 1 Diabetes
Kevan C. Herold; Stephen E. Gitelman; Umesh Masharani; William Hagopian; Brygida Bisikirska; David Donaldson; Kristina Rother; Beverly Diamond; David M. Harlan; Jeffrey A. Bluestone
Diabetes June 2005, Vol.54, 1763-1769. doi:https://doi.org/10.2337/diabetes.54.6.1763
Islet Studies
Imaging β-Cell Death With a Near-Infrared Probe
Diabetes June 2005, Vol.54, 1780-1788. doi:https://doi.org/10.2337/diabetes.54.6.1780
Glucose or Insulin, but not Zinc Ions, Inhibit Glucagon Secretion From Mouse Pancreatic α-Cells
Diabetes June 2005, Vol.54, 1789-1797. doi:https://doi.org/10.2337/diabetes.54.6.1789
Loss of Connexin36 Channels Alters β-Cell Coupling, Islet Synchronization of Glucose-Induced Ca2+ and Insulin Oscillations, and Basal Insulin Release
Magalie A. Ravier; Martin Güldenagel; Anne Charollais; Asllan Gjinovci; Dorothée Caille; Goran Söhl; Claes B. Wollheim; Klaus Willecke; Jean-Claude Henquin; Paolo Meda
Diabetes June 2005, Vol.54, 1798-1807. doi:https://doi.org/10.2337/diabetes.54.6.1798
β-Cell Secretory Products Activate α-Cell ATP-Dependent Potassium Channels to Inhibit Glucagon Release
Diabetes June 2005, Vol.54, 1808-1815. doi:https://doi.org/10.2337/diabetes.54.6.1808
Complications
Albumin Excretion Rate and Cardiovascular Risk: Could the Association Be Explained by Early Microvascular Dysfunction?
Diabetes June 2005, Vol.54, 1816-1822. doi:https://doi.org/10.2337/diabetes.54.6.1816
Therapeutic Neovascularization Using Cord Blood–Derived Endothelial Progenitor Cells for Diabetic Neuropathy
Keiko Naruse; Yoji Hamada; Eitaro Nakashima; Koichi Kato; Ryuichi Mizubayashi; Hideki Kamiya; Yukio Yuzawa; Seiichi Matsuo; Toyoaki Murohara; Tatsuaki Matsubara; Yutaka Oiso; Jiro Nakamura
Diabetes June 2005, Vol.54, 1823-1828. doi:https://doi.org/10.2337/diabetes.54.6.1823
Palmitate-Induced Apoptosis in Cultured Bovine Retinal Pericytes: Roles of NAD(P)H Oxidase, Oxidant Stress, and Ceramide
Diabetes June 2005, Vol.54, 1838-1845. doi:https://doi.org/10.2337/diabetes.54.6.1838
Pharmacology & Therapeutics
Reduction of Hepatic and Adipose Tissue Glucocorticoid Receptor Expression With Antisense Oligonucleotides Improves Hyperglycemia and Hyperlipidemia in Diabetic Rodents Without Causing Systemic Glucocorticoid Antagonism
Lynnetta M. Watts; Vara Prasad Manchem; Thomas A. Leedom; Amber L. Rivard; Robert A. McKay; Dingjiu Bao; Teri Neroladakis; Brett P. Monia; Diane M. Bodenmiller; Julia Xiao-Chun Cao; Hong Yan Zhang; Amy L. Cox; Steven J. Jacobs; M. Dodson Michael; Kyle W. Sloop; Sanjay Bhanot
Diabetes June 2005, Vol.54, 1846-1853. doi:https://doi.org/10.2337/diabetes.54.6.1846
Genetics
Pharmacogenetic Analysis of Rosiglitazone-Induced Hepatosteatosis in New Mouse Models of Type 2 Diabetes
Diabetes June 2005, Vol.54, 1854-1862. doi:https://doi.org/10.2337/diabetes.54.6.1854
Brief Genetics Reports
Fine-Mapping Gene-by-Diet Interactions on Chromosome 13 in a LG/J × SM/J Murine Model of Obesity
Thomas H. Ehrich; Tomas Hrbek; Jane P. Kenney-Hunt; L. Susan Pletscher; Bing Wang; Clay F. Semenkovich; James M. Cheverud
Diabetes June 2005, Vol.54, 1863-1872. doi:https://doi.org/10.2337/diabetes.54.6.1863
Type A Insulin Resistance Syndrome Revealing a Novel Lamin A Mutation
Jacques Young; Louise Morbois-Trabut; Béatrice Couzinet; Olivier Lascols; Elisabeth Dion; Véronique Béréziat; Bruno Fève; Isabelle Richard; Jacqueline Capeau; Philippe Chanson; Corinne Vigouroux
Diabetes June 2005, Vol.54, 1873-1878. doi:https://doi.org/10.2337/diabetes.54.6.1873
“Extended” A1, B8, DR3 Haplotype Shows Remarkable Linkage Disequilibrium but Is Similar to Nonextended Haplotypes in Terms of Diabetes Risk
Akane Ide; Sunanda R. Babu; David T. Robles; Tianbao Wang; Henry A. Erlich; Teodorica L. Bugawan; Marian Rewers; Pamela R. Fain; George S. Eisenbarth
Diabetes June 2005, Vol.54, 1879-1883. doi:https://doi.org/10.2337/diabetes.54.6.1879
Association Testing of the Protein Tyrosine Phosphatase 1B Gene (PTPN1) With Type 2 Diabetes in 7,883 People
Jose C. Florez; Christina M. Agapakis; Noël P. Burtt; Maria Sun; Peter Almgren; Lennart Råstam; Tiinamaija Tuomi; Daniel Gaudet; Thomas J. Hudson; Mark J. Daly; Kristin G. Ardlie; Joel N. Hirschhorn; Leif Groop; David Altshuler
Diabetes June 2005, Vol.54, 1884-1891. doi:https://doi.org/10.2337/diabetes.54.6.1884
Evidence that the Mitochondrial Leucyl tRNA Synthetase (LARS2) Gene Represents a Novel Type 2 Diabetes Susceptibility Gene
Leen M. ‘t Hart; Torben Hansen; Ingrid Rietveld; Jacqueline M. Dekker; Giel Nijpels; George M.C. Janssen; Pascal A. Arp; André G. Uitterlinden; Torben Jørgensen; Knut Borch-Johnsen; Huibert A.P. Pols; Oluf Pedersen; Cornelia M. van Duijn; Robert J. Heine; J. Antonie Maassen
Diabetes June 2005, Vol.54, 1892-1895. doi:https://doi.org/10.2337/diabetes.54.6.1892