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Issues
1 July 2005
ISSN 0012-1797
EISSN 1939-327X
Perspectives in Diabetes
Nutritional Epigenomics of Metabolic Syndrome: New Perspective Against the Epidemic
Topics:
epigenetics
,
genes
,
metabolic syndrome x
,
placenta
,
diet
Diabetes July 2005, Vol.54, 1899-1906. doi:https://doi.org/10.2337/diabetes.54.7.1899
Metabolism
Effect of Fructose Overfeeding and Fish Oil Administration on Hepatic De Novo Lipogenesis and Insulin Sensitivity in Healthy Men
Topics:
diet
,
fish oils
,
fructose
,
glucose
,
overnutrition
Diabetes July 2005, Vol.54, 1907-1913. doi:https://doi.org/10.2337/diabetes.54.7.1907
Assessing the Predictive Accuracy of QUICKI as a Surrogate Index for Insulin Sensitivity Using a Calibration Model
Topics:
calibration
,
fasting
,
glucose
,
hypertension
,
insulin
Diabetes July 2005, Vol.54, 1914-1925. doi:https://doi.org/10.2337/diabetes.54.7.1914
A High-Fat Diet Coordinately Downregulates Genes Required for Mitochondrial Oxidative Phosphorylation in Skeletal Muscle
Lauren M. Sparks; Hui Xie; Robert A. Koza; Randall Mynatt; Matthew W. Hulver; George A. Bray; Steven R. Smith
Topics:
dna, mitochondrial
,
genes
,
mice
,
mitochondria
,
skeletal muscles
Diabetes July 2005, Vol.54, 1926-1933. doi:https://doi.org/10.2337/diabetes.54.7.1926
A Multicompartmental Model of In Vivo Adipose Tissue Glycerol Kinetics and Capillary Permeability in Lean and Obese Humans
Topics:
adipose tissue
,
glycerol
,
obesity
,
triglycerides
Diabetes July 2005, Vol.54, 1934-1941. doi:https://doi.org/10.2337/diabetes.54.7.1934
Obesity and Type 2 Diabetes Impair Insulin-Induced Suppression of Glycogenolysis as Well as Gluconeogenesis
Topics:
diabetes mellitus, type 2
,
gluconeogenesis
,
glucose
,
glycogenolysis
,
insulin
Diabetes July 2005, Vol.54, 1942-1948. doi:https://doi.org/10.2337/diabetes.54.7.1942
Dual Role of Phosphofructokinase-2/Fructose Bisphosphatase-2 in Regulating the Compartmentation and Expression of Glucokinase in Hepatocytes
Topics:
fructose
,
glucagon
,
glucokinase
,
hepatocytes
Diabetes July 2005, Vol.54, 1949-1957. doi:https://doi.org/10.2337/diabetes.54.7.1949
Signal Transduction
Impact of the Liver-Specific Expression of SHIP2 (SH2-Containing Inositol 5′-Phosphatase 2) on Insulin Signaling and Glucose Metabolism in Mice
Kazuhito Fukui; Tsutomu Wada; Syota Kagawa; Kiyofumi Nagira; Mariko Ikubo; Hajime Ishihara; Masashi Kobayashi; Toshiyasu Sasaoka
Topics:
insulin
,
liver
,
mice
,
proto-oncogene proteins c-akt
,
phosphorylation
Diabetes July 2005, Vol.54, 1958-1967. doi:https://doi.org/10.2337/diabetes.54.7.1958
The Regulation of Fatty Acid Synthase by STAT5A
Topics:
adipocytes
,
fatty-acid synthase
,
luciferases
,
rna, messenger
,
somatotropin
Diabetes July 2005, Vol.54, 1968-1975. doi:https://doi.org/10.2337/diabetes.54.7.1968
Role of Upstream Stimulatory Factors in Regulation of Renal Transforming Growth Factor-β1
Topics:
carbohydrates
,
glucose
,
kidney
,
mesangial cells
,
mice
Diabetes July 2005, Vol.54, 1976-1984. doi:https://doi.org/10.2337/diabetes.54.7.1976
Obesity Studies
Distinct Forebrain and Caudal Brainstem Contributions to the Neuropeptide Y Mediation of Ghrelin Hyperphagia
Topics:
cerebral ventricles
,
ghrelin
,
heart ventricle
,
neuropeptide y
,
cerebral aqueduct
Diabetes July 2005, Vol.54, 1985-1993. doi:https://doi.org/10.2337/diabetes.54.7.1985
Long-Term Efficacy of Leptin Replacement in Patients With Generalized Lipodystrophy
Topics:
familial generalized lipodystrophy
,
leptin
,
insulin
,
insulin resistance
,
triglycerides
Diabetes July 2005, Vol.54, 1994-2002. doi:https://doi.org/10.2337/diabetes.54.7.1994
Autocrine Action of Adiponectin on Human Fat Cells Prevents the Release of Insulin Resistance-Inducing Factors
Topics:
adipocytes
,
adiponectin
,
insulin
,
cytokine
,
skeletal myocytes
Diabetes July 2005, Vol.54, 2003-2011. doi:https://doi.org/10.2337/diabetes.54.7.2003
Role of Selective Leptin Resistance in Diet-Induced Obesity Hypertension
Topics:
leptin
,
mice
,
diet, high-fat
,
diet
,
obesity
Diabetes July 2005, Vol.54, 2012-2018. doi:https://doi.org/10.2337/diabetes.54.7.2012
NOD B-cells Are Insufficient to Incite T-Cell-Mediated Anti-islet Autoimmunity
Topics:
autoimmunity
,
b-lymphocytes
,
chimera organism
,
mice
,
molecule
Diabetes July 2005, Vol.54, 2019-2025. doi:https://doi.org/10.2337/diabetes.54.7.2019
Immunology and Transplantation
Maternal Factors in a Model of Type 1 Diabetes Differentially Affect the Development of Insulitis and Overt Diabetes in Offspring
Topics:
diabetes mellitus, type 1
,
diabetes, pregestational
,
mice
Diabetes July 2005, Vol.54, 2026-2031. doi:https://doi.org/10.2337/diabetes.54.7.2026
The Influence of the Major Histocompatibility Complex on Development of Autoimmune Diabetes in RIP-B7.1 Mice
Topics:
mice
,
severe combined immunodeficiency
,
t-lymphocytes
,
autoimmunity
,
molecule
Diabetes July 2005, Vol.54, 2032-2040. doi:https://doi.org/10.2337/diabetes.54.7.2032
Immune Cell Infiltration, Cytokine Expression, and β-Cell Apoptosis During the Development of Type 1 Diabetes in the Spontaneously Diabetic LEW.1AR1/Ztm-iddm Rat
Topics:
cytokine
,
diabetes mellitus, type 1
,
pancreas
,
apoptosis
,
tumor necrosis factors
Diabetes July 2005, Vol.54, 2041-2052. doi:https://doi.org/10.2337/diabetes.54.7.2041
Identification of Naturally Processed HLA-A2—Restricted Proinsulin Epitopes by Reverse Immunology
Yousra Hassainya; Francisco Garcia-Pons; Roland Kratzer; Vivian Lindo; Fiona Greer; François A. Lemonnier; Gabriele Niedermann; Peter M. van Endert
Topics:
epitopes
,
hla-a2 antigen
,
mice
,
multicatalytic endopeptidase complex
,
peptides
Diabetes July 2005, Vol.54, 2053-2059. doi:https://doi.org/10.2337/diabetes.54.7.2053
Five-Year Follow-Up After Clinical Islet Transplantation
Edmond A. Ryan; Breay W. Paty; Peter A. Senior; David Bigam; Eman Alfadhli; Norman M. Kneteman; Jonathan R.T. Lakey; A.M. James Shapiro
Topics:
c-peptide
,
follow-up
,
insulin
,
islets of langerhans transplantation
,
transplantation
Diabetes July 2005, Vol.54, 2060-2069. doi:https://doi.org/10.2337/diabetes.54.7.2060
Islet Studies
Saturated and cis/trans Unsaturated Acyl CoA Esters Differentially Regulate Wild-Type and Polymorphic β-Cell ATP-Sensitive K+ Channels
Topics:
acyl coenzyme a
,
coenzyme a
,
tissue membrane
,
hydrophobicity
Diabetes July 2005, Vol.54, 2070-2079. doi:https://doi.org/10.2337/diabetes.54.7.2070
Role for β1 Integrin and Its Associated α3, α5, and α6 Subunits in Development of the Human Fetal Pancreas
Diabetes July 2005, Vol.54, 2080-2089. doi:https://doi.org/10.2337/diabetes.54.7.2080
Targeted Inactivation of Hepatocyte Growth Factor Receptor c-met in β-Cells Leads to Defective Insulin Secretion and GLUT-2 Downregulation Without Alteration of β-Cell Mass
Jennifer Roccisana; Vasumathi Reddy; Rupangi C. Vasavada; Jose A. Gonzalez-Pertusa; Mark A. Magnuson; Adolfo Garcia-Ocaña
Diabetes July 2005, Vol.54, 2090-2102. doi:https://doi.org/10.2337/diabetes.54.7.2090
Peptide-Mediated Targeting of the Islets of Langerhans
Kausar N. Samli; Michael J. McGuire; Christopher B. Newgard; Stephen Albert Johnston; Kathlynn C. Brown
Topics:
bacteriophages
,
endocrine pancreas
,
peptides
,
rats
,
ripk2 gene
Diabetes July 2005, Vol.54, 2103-2108. doi:https://doi.org/10.2337/diabetes.54.7.2103
Overexpression of Glutathione Peroxidase With Two Isoforms of Superoxide Dismutase Protects Mouse Islets From Oxidative Injury and Improves Islet Graft Function
Tharun B. Mysore; Trixie A. Shinkel; James Collins; Evelyn J. Salvaris; Nella Fisicaro; Lisa J. Murray-Segal; Lucinda E.A. Johnson; Diana A. Lepore; Stacey N. Walters; Rebecca Stokes; Abhilash P. Chandra; Philip J. O’Connell; Anthony J.F. d’Apice; Peter J. Cowan
Topics:
animals, transgenic
,
antioxidants
,
mice
,
tissue transplants
,
glutathione peroxidase
Diabetes July 2005, Vol.54, 2109-2116. doi:https://doi.org/10.2337/diabetes.54.7.2109
Aberrant Processing of Human Proislet Amyloid Polypeptide Results in Increased Amyloid Formation
Topics:
amyloid
,
congo red
,
iapp gene
,
prohormone
,
transfection
Diabetes July 2005, Vol.54, 2117-2125. doi:https://doi.org/10.2337/diabetes.54.7.2117
Inhibition of Purinoceptors Amplifies Glucose-Stimulated Insulin Release With Removal of its Pulsatility
Topics:
glucose
,
insulin
,
purinoceptor
,
pancreas
Diabetes July 2005, Vol.54, 2126-2131. doi:https://doi.org/10.2337/diabetes.54.7.2126
Redox Control of Exocytosis: Regulatory Role of NADPH, Thioredoxin, and Glutaredoxin
Rosita Ivarsson; Roel Quintens; Sandra Dejonghe; Katsura Tsukamoto; Peter in ’t Veld; Erik Renström; Frans C. Schuit
Topics:
exocytosis
,
glucose
,
insulin
,
nadp
,
rna, messenger
Diabetes July 2005, Vol.54, 2132-2142. doi:https://doi.org/10.2337/diabetes.54.7.2132
Complications
Tissue Factor as a Link Between Wounding and Tissue Repair
Jiang Chen; Michael Kasper; Tobias Heck; Katsumi Nakagawa; Per M. Humpert; Ling Bai; Gang Wu; Youming Zhang; Thomas Luther; Martin Andrassy; Stephan Schiekofer; Andreas Hamann; Michael Morcos; Baoshen Chen; David M. Stern; Peter P. Nawroth; Angelika Bierhaus
Topics:
mice
,
thromboplastin
,
vascular endothelial growth factor a
,
wound healing
,
gene therapy, somatic
Diabetes July 2005, Vol.54, 2143-2154. doi:https://doi.org/10.2337/diabetes.54.7.2143
Impaired Arachidonic Acid–Mediated Activation of Large-Conductance Ca2+-Activated K+ Channels in Coronary Arterial Smooth Muscle Cells in Zucker Diabetic Fatty Rats
Tong Lu; Xiao-Li Wang; Tongrong He; Wei Zhou; Terry L. Kaduce; Zvonimir S. Katusic; Arthur A. Spector; Hon-Chi Lee
Topics:
coronary artery
,
rats
,
myocytes, smooth muscle
,
arachidonic acid
,
iloprost
Diabetes July 2005, Vol.54, 2155-2163. doi:https://doi.org/10.2337/diabetes.54.7.2155
The Early Natural History of Nephropathy in Type 1 Diabetes: III. Predictors of 5-Year Urinary Albumin Excretion Rate Patterns in Initially Normoalbuminuric Patients
Julia M. Steinke; Alan R. Sinaiko; Michael S. Kramer; Samy Suissa; Blanche M. Chavers; Michael Mauer; for the International Diabetic Nephropathy Study Group
Topics:
albumins
,
diabetes mellitus, type 1
,
diabetic nephropathy
,
excretory function
,
glomerular filtration rate
Diabetes July 2005, Vol.54, 2164-2171. doi:https://doi.org/10.2337/diabetes.54.7.2164
Heparanase-1 Gene Expression and Regulation by High Glucose in Renal Epithelial Cells : A Potential Role in the Pathogenesis of Proteinuria in Diabetic Patients
Justin B. Maxhimer; Michael Somenek; Geetha Rao; Catherine E. Pesce; David Baldwin, Jr.; Paolo Gattuso; Melvin M. Schwartz; Edmund J. Lewis; Richard A. Prinz; Xiulong Xu
Topics:
diabetic nephropathy
,
epithelial cells
,
glucose
,
kidney
,
kidney glomerulus
Diabetes July 2005, Vol.54, 2172-2178. doi:https://doi.org/10.2337/diabetes.54.7.2172
Metformin Prevents High-Glucose–Induced Endothelial Cell Death Through a Mitochondrial Permeability Transition-Dependent Process
Dominique Detaille; Bruno Guigas; Christiane Chauvin; Cécile Batandier; Eric Fontaine; Nicolas Wiernsperger; Xavier Leverve
Topics:
endothelial cells
,
glucose
,
metformin
,
cyclosporine
,
cytochrome c
Diabetes July 2005, Vol.54, 2179-2187. doi:https://doi.org/10.2337/diabetes.54.7.2179
The Effect of Ruboxistaurin on Visual Loss in Patients With Moderately Severe to Very Severe Nonproliferative Diabetic Retinopathy : Initial Results of the Protein Kinase C β Inhibitor Diabetic Retinopathy Study (PKC-DRS) Multicenter Randomized Clinical Trial
Topics:
adverse event
,
blindness
,
diabetic retinopathy
,
eye
,
light coagulation
Diabetes July 2005, Vol.54, 2188-2197. doi:https://doi.org/10.2337/diabetes.54.7.2188
Advanced Glycation End Product Precursors Impair ABCA1-Dependent Cholesterol Removal From Cells
Marisa Passarelli; Chongren Tang; Thomas O. McDonald; Kevin D. O’Brien; Ross G. Gerrity; Jay W. Heinecke; John F. Oram
Topics:
abca1 gene
,
apolipoprotein a-i
,
cholesterol
,
macrophages
Diabetes July 2005, Vol.54, 2198-2205. doi:https://doi.org/10.2337/diabetes.54.7.2198
Rosiglitazone Improves Glomerular Hyperfiltration, Renal Endothelial Dysfunction, and Microalbuminuria of Incipient Diabetic Nephropathy in Patients
Topics:
diabetic nephropathy
,
endothelial dysfunction
,
glomerular filtration rate
,
kidney
,
kidney glomerulus
Diabetes July 2005, Vol.54, 2206-2211. doi:https://doi.org/10.2337/diabetes.54.7.2206
Pharmacology and Therapeutics
Erythromycin Antagonizes the Deceleration of Gastric Emptying by Glucagon-Like Peptide 1 and Unmasks Its Insulinotropic Effect in Healthy Subjects
Topics:
erythromycin
,
gastric emptying
,
glucagon-like peptide 1
,
insulin
Diabetes July 2005, Vol.54, 2212-2218. doi:https://doi.org/10.2337/diabetes.54.7.2212
Tempol Reduces Oxidative Stress, Improves Insulin Sensitivity, Decreases Renal Dopamine D1 Receptor Hyperphosphorylation, and Restores D1 Receptor–G-Protein Coupling and Function in Obese Zucker Rats
Topics:
dopamine d1 receptor
,
gtp-binding proteins
,
kidney
,
obesity
,
oxidative stress
Diabetes July 2005, Vol.54, 2219-2226. doi:https://doi.org/10.2337/diabetes.54.7.2219
Long-Term Treatment With Rosiglitazone and Metformin Reduces the Extent of, but Does Not Prevent, Islet Amyloid Deposition in Mice Expressing the Gene for Human Islet Amyloid Polypeptide
Rebecca L. Hull; Zhen-Ping Shen; Melissah R. Watts; Keiichi Kodama; Darcy B. Carr; Kristina M. Utzschneider; Sakeneh Zraika; Feng Wang; Steven E. Kahn
Topics:
amyloid
,
glucose
,
insulin
,
metformin
,
metformin/rosiglitazone
Diabetes July 2005, Vol.54, 2235-2244. doi:https://doi.org/10.2337/diabetes.54.7.2235
Brief Genetics Reports
Genetic Variation in Adiponectin Receptor 1 and Adiponectin Receptor 2 Is Associated With Type 2 Diabetes in the Old Order Amish
Coleen M. Damcott; Sandra H. Ott; Toni I. Pollin; Laurie J. Reinhart; Jian Wang; Jeffrey R. O’Connell; Braxton D. Mitchell; Alan R. Shuldiner
Topics:
diabetes mellitus, type 2
,
receptors, adiponectin
,
single nucleotide polymorphism
,
sequence analysis
,
genetics
Diabetes July 2005, Vol.54, 2245-2250. doi:https://doi.org/10.2337/diabetes.54.7.2245
Hepatic Lipase Gene Variant −514C>T Is Associated With Lipoprotein and Insulin Sensitivity Response to Regular Exercise: The HERITAGE Family Study
Margarita Teran-Garcia; Nicola Santoro; Tuomo Rankinen; Jean Bergeron; Treva Rice; Arthur S. Leon; D.C. Rao; James S. Skinner; Richard N. Bergman; Jean-Pierre Després; Claude Bouchard
Topics:
chief complaint
,
genes
,
genotype
,
hepatic lipase
,
lipoprotein lipase
Diabetes July 2005, Vol.54, 2251-2255. doi:https://doi.org/10.2337/diabetes.54.7.2251
Polymorphisms in the SLC2A2 (GLUT2) Gene Are Associated With the Conversion From Impaired Glucose Tolerance to Type 2 Diabetes : The Finnish Diabetes Prevention Study
Olli Laukkanen; Jaana Lindström; Johan Eriksson; Timo T. Valle; Helena Hämäläinen; Pirjo Ilanne-Parikka; Sirkka Keinänen-Kiukaanniemi; Jaakko Tuomilehto; Matti Uusitupa; Markku Laakso
Topics:
diabetes mellitus, type 2
,
genes
,
glucose intolerance
,
single nucleotide polymorphism
,
diabetes prevention
Diabetes July 2005, Vol.54, 2256-2260. doi:https://doi.org/10.2337/diabetes.54.7.2256
Evidence of an Association Between the Arg72 Allele of the Peptide YY and Increased Risk of Type 2 Diabetes
Signe S. Torekov; Lesli H. Larsen; Charlotte Glümer; Knut Borch-Johnsen; Torben Jørgensen; Jens J. Holst; Ole D. Madsen; Torben Hansen; Oluf Pedersen
Topics:
diabetes mellitus, type 2
,
glucose
,
obesity
,
overweight
,
alleles
Diabetes July 2005, Vol.54, 2261-2265. doi:https://doi.org/10.2337/diabetes.54.7.2261
Retraction
Retraction
Topics:
glucose
,
insulin
,
interstitial fluid
,
obesity
Diabetes July 2005, Vol.54, 2266. doi:https://doi.org/10.2337/diabetes.54.7.2266