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Perspectives in Diabetes

Nutritional Epigenomics of Metabolic Syndrome: New Perspective Against the Epidemic

Catherine Gallou-Kabani; Claudine Junien

Abstract

View articletitled, Nutritional Epigenomics of Metabolic Syndrome: New Perspective Against the Epidemic

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Topics: epigenetics , genes , metabolic syndrome x , placenta , diet

Diabetes July 2005, Vol.54, 1899-1906. doi:https://doi.org/10.2337/diabetes.54.7.1899

Metabolism

Effect of Fructose Overfeeding and Fish Oil Administration on Hepatic De Novo Lipogenesis and Insulin Sensitivity in Healthy Men

David Faeh; Kaori Minehira; Jean-Marc Schwarz; Raj Periasamy; Seongsoo Park; Luc Tappy

Abstract

View articletitled, Effect of Fructose Overfeeding and Fish Oil Administration on Hepatic De Novo Lipogenesis and Insulin Sensitivity in Healthy Men

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Topics: diet , fish oils , fructose , glucose , overnutrition

Diabetes July 2005, Vol.54, 1907-1913. doi:https://doi.org/10.2337/diabetes.54.7.1907

Assessing the Predictive Accuracy of QUICKI as a Surrogate Index for Insulin Sensitivity Using a Calibration Model

Hui Chen; Gail Sullivan; Michael J. Quon

Abstract

View articletitled, Assessing the Predictive Accuracy of QUICKI as a Surrogate Index for Insulin Sensitivity Using a Calibration Model

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Topics: calibration , fasting , glucose , hypertension , insulin

Diabetes July 2005, Vol.54, 1914-1925. doi:https://doi.org/10.2337/diabetes.54.7.1914

A High-Fat Diet Coordinately Downregulates Genes Required for Mitochondrial Oxidative Phosphorylation in Skeletal Muscle

Lauren M. Sparks; Hui Xie; Robert A. Koza; Randall Mynatt; Matthew W. Hulver; George A. Bray; Steven R. Smith

Abstracts

View articletitled, A High-Fat Diet Coordinately Downregulates Genes Required for Mitochondrial Oxidative Phosphorylation in Skeletal Muscle

Supplementary data

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Topics: dna, mitochondrial , genes , mice , mitochondria , skeletal muscles

Diabetes July 2005, Vol.54, 1926-1933. doi:https://doi.org/10.2337/diabetes.54.7.1926

A Multicompartmental Model of In Vivo Adipose Tissue Glycerol Kinetics and Capillary Permeability in Lean and Obese Humans

Simon W. Coppack; David L. Chinkes; John M. Miles; Bruce W. Patterson; Samuel Klein

Abstract

View articletitled, A Multicompartmental Model of In Vivo Adipose Tissue Glycerol Kinetics and Capillary Permeability in Lean and Obese Humans

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Topics: adipose tissue , glycerol , obesity , triglycerides

Diabetes July 2005, Vol.54, 1934-1941. doi:https://doi.org/10.2337/diabetes.54.7.1934

Obesity and Type 2 Diabetes Impair Insulin-Induced Suppression of Glycogenolysis as Well as Gluconeogenesis

Rita Basu; Visvanathan Chandramouli; Betty Dicke; Bernard Landau; Robert Rizza

Abstract

View articletitled, Obesity and Type 2 Diabetes Impair Insulin-Induced Suppression of Glycogenolysis as Well as Gluconeogenesis

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Topics: diabetes mellitus, type 2 , gluconeogenesis , glucose , glycogenolysis , insulin

Diabetes July 2005, Vol.54, 1942-1948. doi:https://doi.org/10.2337/diabetes.54.7.1942

Dual Role of Phosphofructokinase-2/Fructose Bisphosphatase-2 in Regulating the Compartmentation and Expression of Glucokinase in Hepatocytes

Victoria A. Payne; Catherine Arden; Chaodong Wu; Alex J. Lange; Loranne Agius

Abstract

View articletitled, Dual Role of Phosphofructokinase-2/Fructose Bisphosphatase-2 in Regulating the Compartmentation and Expression of Glucokinase in Hepatocytes

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Topics: fructose , glucagon , glucokinase , hepatocytes

Diabetes July 2005, Vol.54, 1949-1957. doi:https://doi.org/10.2337/diabetes.54.7.1949

Signal Transduction

Impact of the Liver-Specific Expression of SHIP2 (SH2-Containing Inositol 5′-Phosphatase 2) on Insulin Signaling and Glucose Metabolism in Mice

Kazuhito Fukui; Tsutomu Wada; Syota Kagawa; Kiyofumi Nagira; Mariko Ikubo; Hajime Ishihara; Masashi Kobayashi; Toshiyasu Sasaoka

Abstract

View articletitled, Impact of the Liver-Specific Expression of SHIP2 (SH2-Containing Inositol 5′-Phosphatase 2) on Insulin Signaling and Glucose Metabolism in Mice

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Topics: insulin , liver , mice , proto-oncogene proteins c-akt , phosphorylation

Diabetes July 2005, Vol.54, 1958-1967. doi:https://doi.org/10.2337/diabetes.54.7.1958

The Regulation of Fatty Acid Synthase by STAT5A

Jessica C. Hogan; Jacqueline M. Stephens

Abstract

View articletitled, The Regulation of Fatty Acid Synthase by STAT5A

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Topics: adipocytes , fatty-acid synthase , luciferases , rna, messenger , somatotropin

Diabetes July 2005, Vol.54, 1968-1975. doi:https://doi.org/10.2337/diabetes.54.7.1968

Role of Upstream Stimulatory Factors in Regulation of Renal Transforming Growth Factor-β1

Yanqing Zhu; Marta Casado; Sophie Vaulont; Kumar Sharma

Abstracts

View articletitled, Role of Upstream Stimulatory Factors in Regulation of Renal Transforming Growth Factor-β1

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Topics: carbohydrates , glucose , kidney , mesangial cells , mice

Diabetes July 2005, Vol.54, 1976-1984. doi:https://doi.org/10.2337/diabetes.54.7.1976

Obesity Studies

Distinct Forebrain and Caudal Brainstem Contributions to the Neuropeptide Y Mediation of Ghrelin Hyperphagia

Lucy F. Faulconbridge; Harvey J. Grill; Joel M. Kaplan

Abstracts

View articletitled, Distinct Forebrain and Caudal Brainstem Contributions to the Neuropeptide Y Mediation of Ghrelin Hyperphagia

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Topics: cerebral ventricles , ghrelin , heart ventricle , neuropeptide y , cerebral aqueduct

Diabetes July 2005, Vol.54, 1985-1993. doi:https://doi.org/10.2337/diabetes.54.7.1985

Long-Term Efficacy of Leptin Replacement in Patients With Generalized Lipodystrophy

Edward D. Javor; Elaine K. Cochran; Carla Musso; Janice Ryan Young; Alex M. DePaoli; Phillip Gorden

Abstracts

View articletitled, Long-Term Efficacy of Leptin Replacement in Patients With Generalized Lipodystrophy

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Topics: familial generalized lipodystrophy , leptin , insulin , insulin resistance , triglycerides

Diabetes July 2005, Vol.54, 1994-2002. doi:https://doi.org/10.2337/diabetes.54.7.1994

Autocrine Action of Adiponectin on Human Fat Cells Prevents the Release of Insulin Resistance-Inducing Factors

Daniela Dietze-Schroeder; Henrike Sell; Mathias Uhlig; Marlis Koenen; Jürgen Eckel

Abstracts

View articletitled, Autocrine Action of Adiponectin on Human Fat Cells Prevents the Release of Insulin Resistance-Inducing Factors

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Topics: adipocytes , adiponectin , insulin , cytokine , skeletal myocytes

Diabetes July 2005, Vol.54, 2003-2011. doi:https://doi.org/10.2337/diabetes.54.7.2003

Role of Selective Leptin Resistance in Diet-Induced Obesity Hypertension

Kamal Rahmouni; Donald A. Morgan; Gina M. Morgan; Allyn L. Mark; William G. Haynes

Abstracts

View articletitled, Role of Selective Leptin Resistance in Diet-Induced Obesity Hypertension

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Topics: leptin , mice , diet, high-fat , diet , obesity

Diabetes July 2005, Vol.54, 2012-2018. doi:https://doi.org/10.2337/diabetes.54.7.2012

NOD B-cells Are Insufficient to Incite T-Cell-Mediated Anti-islet Autoimmunity

Daniel J. Moore; Hooman Noorchashm; Tina H. Lin; Siri A. Greeley; Ali Naji

Abstracts

View articletitled, NOD B-cells Are Insufficient to Incite T-Cell-Mediated Anti-islet Autoimmunity

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Topics: autoimmunity , b-lymphocytes , chimera organism , mice , molecule

Diabetes July 2005, Vol.54, 2019-2025. doi:https://doi.org/10.2337/diabetes.54.7.2019

Immunology and Transplantation

Maternal Factors in a Model of Type 1 Diabetes Differentially Affect the Development of Insulitis and Overt Diabetes in Offspring

Yukiko Kagohashi; Jun Udagawa; Norio Abiru; Masakazu Kobayashi; Kenji Moriyama; Hiroki Otani

Abstracts

View articletitled, Maternal Factors in a Model of Type 1 Diabetes Differentially Affect the Development of Insulitis and Overt Diabetes in Offspring

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Topics: diabetes mellitus, type 1 , diabetes, pregestational , mice

Diabetes July 2005, Vol.54, 2026-2031. doi:https://doi.org/10.2337/diabetes.54.7.2026

The Influence of the Major Histocompatibility Complex on Development of Autoimmune Diabetes in RIP-B7.1 Mice

F. Susan Wong; Wei Du; Ian J. Thomas; Li Wen

Abstracts

View articletitled, The Influence of the Major Histocompatibility Complex on Development of Autoimmune Diabetes in RIP-B7.1 Mice

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Topics: mice , severe combined immunodeficiency , t-lymphocytes , autoimmunity , molecule

Diabetes July 2005, Vol.54, 2032-2040. doi:https://doi.org/10.2337/diabetes.54.7.2032

Immune Cell Infiltration, Cytokine Expression, and β-Cell Apoptosis During the Development of Type 1 Diabetes in the Spontaneously Diabetic LEW.1AR1/Ztm-iddm Rat

Anne Jörns; Armin Günther; Hans-Jürgen Hedrich; Dirk Wedekind; Markus Tiedge; Sigurd Lenzen

Abstract

View articletitled, Immune Cell Infiltration, Cytokine Expression, and β-Cell Apoptosis During the Development of Type 1 Diabetes in the Spontaneously Diabetic LEW.1AR1/Ztm-iddm Rat

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Topics: cytokine , diabetes mellitus, type 1 , pancreas , apoptosis , tumor necrosis factors

Diabetes July 2005, Vol.54, 2041-2052. doi:https://doi.org/10.2337/diabetes.54.7.2041

Identification of Naturally Processed HLA-A2—Restricted Proinsulin Epitopes by Reverse Immunology

Yousra Hassainya; Francisco Garcia-Pons; Roland Kratzer; Vivian Lindo; Fiona Greer; François A. Lemonnier; Gabriele Niedermann; Peter M. van Endert

Abstract

View articletitled, Identification of Naturally Processed HLA-A2—Restricted Proinsulin Epitopes by Reverse Immunology

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Topics: epitopes , hla-a2 antigen , mice , multicatalytic endopeptidase complex , peptides

Diabetes July 2005, Vol.54, 2053-2059. doi:https://doi.org/10.2337/diabetes.54.7.2053

Five-Year Follow-Up After Clinical Islet Transplantation

Edmond A. Ryan; Breay W. Paty; Peter A. Senior; David Bigam; Eman Alfadhli; Norman M. Kneteman; Jonathan R.T. Lakey; A.M. James Shapiro

Abstract

View articletitled, Five-Year Follow-Up After Clinical Islet Transplantation

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Topics: c-peptide , follow-up , insulin , islets of langerhans transplantation , transplantation

Diabetes July 2005, Vol.54, 2060-2069. doi:https://doi.org/10.2337/diabetes.54.7.2060

Islet Studies

Saturated and cis/trans Unsaturated Acyl CoA Esters Differentially Regulate Wild-Type and Polymorphic β-Cell ATP-Sensitive K⁺ Channels

Michael J. Riedel; Peter E. Light

Abstract

View articletitled, Saturated and cis/trans Unsaturated Acyl CoA Esters Differentially Regulate Wild-Type and Polymorphic β-Cell ATP-Sensitive K+ Channels

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Topics: acyl coenzyme a , coenzyme a , tissue membrane , hydrophobicity

Diabetes July 2005, Vol.54, 2070-2079. doi:https://doi.org/10.2337/diabetes.54.7.2070

Role for β1 Integrin and Its Associated α3, α5, and α6 Subunits in Development of the Human Fetal Pancreas

Rennian Wang; Jinming Li; Kristina Lyte; Nina K. Yashpal; Fraser Fellows; Cynthia G. Goodyer

Abstracts

View articletitled, Role for β1 Integrin and Its Associated α3, α5, and α6 Subunits in Development of the Human Fetal Pancreas

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Topics: insulin , integrins , pancreas , fetus

Diabetes July 2005, Vol.54, 2080-2089. doi:https://doi.org/10.2337/diabetes.54.7.2080

Targeted Inactivation of Hepatocyte Growth Factor Receptor c-met in β-Cells Leads to Defective Insulin Secretion and GLUT-2 Downregulation Without Alteration of β-Cell Mass

Jennifer Roccisana; Vasumathi Reddy; Rupangi C. Vasavada; Jose A. Gonzalez-Pertusa; Mark A. Magnuson; Adolfo Garcia-Ocaña

Abstracts

View articletitled, Targeted Inactivation of Hepatocyte Growth Factor Receptor c-met in β-Cells Leads to Defective Insulin Secretion and GLUT-2 Downregulation Without Alteration of β-Cell Mass

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Topics: insulin , mice , pancreas , met gene , glucose

Diabetes July 2005, Vol.54, 2090-2102. doi:https://doi.org/10.2337/diabetes.54.7.2090

Peptide-Mediated Targeting of the Islets of Langerhans

Kausar N. Samli; Michael J. McGuire; Christopher B. Newgard; Stephen Albert Johnston; Kathlynn C. Brown

Abstracts

View articletitled, Peptide-Mediated Targeting of the Islets of Langerhans

Supplementary data

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Topics: bacteriophages , endocrine pancreas , peptides , rats , ripk2 gene

Diabetes July 2005, Vol.54, 2103-2108. doi:https://doi.org/10.2337/diabetes.54.7.2103

Overexpression of Glutathione Peroxidase With Two Isoforms of Superoxide Dismutase Protects Mouse Islets From Oxidative Injury and Improves Islet Graft Function

Tharun B. Mysore; Trixie A. Shinkel; James Collins; Evelyn J. Salvaris; Nella Fisicaro; Lisa J. Murray-Segal; Lucinda E.A. Johnson; Diana A. Lepore; Stacey N. Walters; Rebecca Stokes; Abhilash P. Chandra; Philip J. O’Connell; Anthony J.F. d’Apice; Peter J. Cowan

Abstracts

View articletitled, Overexpression of Glutathione Peroxidase With Two Isoforms of Superoxide Dismutase Protects Mouse Islets From Oxidative Injury and Improves Islet Graft Function

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Topics: animals, transgenic , antioxidants , mice , tissue transplants , glutathione peroxidase

Diabetes July 2005, Vol.54, 2109-2116. doi:https://doi.org/10.2337/diabetes.54.7.2109

Aberrant Processing of Human Proislet Amyloid Polypeptide Results in Increased Amyloid Formation

Johan F. Paulsson; Gunilla T. Westermark

Abstract

View articletitled, Aberrant Processing of Human Proislet Amyloid Polypeptide Results in Increased Amyloid Formation

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Topics: amyloid , congo red , iapp gene , prohormone , transfection

Diabetes July 2005, Vol.54, 2117-2125. doi:https://doi.org/10.2337/diabetes.54.7.2117

Inhibition of Purinoceptors Amplifies Glucose-Stimulated Insulin Release With Removal of its Pulsatility

Albert Salehi; Saleem S. Qader; Eva Grapengiesser; Bo Hellman

Abstract

View articletitled, Inhibition of Purinoceptors Amplifies Glucose-Stimulated Insulin Release With Removal of its Pulsatility

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Topics: glucose , insulin , purinoceptor , pancreas

Diabetes July 2005, Vol.54, 2126-2131. doi:https://doi.org/10.2337/diabetes.54.7.2126

Redox Control of Exocytosis: Regulatory Role of NADPH, Thioredoxin, and Glutaredoxin

Rosita Ivarsson; Roel Quintens; Sandra Dejonghe; Katsura Tsukamoto; Peter in ’t Veld; Erik Renström; Frans C. Schuit

Abstract

View articletitled, Redox Control of Exocytosis: Regulatory Role of NADPH, Thioredoxin, and Glutaredoxin

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Topics: exocytosis , glucose , insulin , nadp , rna, messenger

Diabetes July 2005, Vol.54, 2132-2142. doi:https://doi.org/10.2337/diabetes.54.7.2132

Complications

Tissue Factor as a Link Between Wounding and Tissue Repair

Jiang Chen; Michael Kasper; Tobias Heck; Katsumi Nakagawa; Per M. Humpert; Ling Bai; Gang Wu; Youming Zhang; Thomas Luther; Martin Andrassy; Stephan Schiekofer; Andreas Hamann; Michael Morcos; Baoshen Chen; David M. Stern; Peter P. Nawroth; Angelika Bierhaus

Abstract

View articletitled, Tissue Factor as a Link Between Wounding and Tissue Repair

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Topics: mice , thromboplastin , vascular endothelial growth factor a , wound healing , gene therapy, somatic

Diabetes July 2005, Vol.54, 2143-2154. doi:https://doi.org/10.2337/diabetes.54.7.2143

Impaired Arachidonic Acid–Mediated Activation of Large-Conductance Ca²⁺-Activated K⁺ Channels in Coronary Arterial Smooth Muscle Cells in Zucker Diabetic Fatty Rats

Tong Lu; Xiao-Li Wang; Tongrong He; Wei Zhou; Terry L. Kaduce; Zvonimir S. Katusic; Arthur A. Spector; Hon-Chi Lee

Abstract

View articletitled, Impaired Arachidonic Acid–Mediated Activation of Large-Conductance Ca2+-Activated K+ Channels in Coronary Arterial Smooth Muscle Cells in Zucker Diabetic Fatty Rats

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Topics: coronary artery , rats , myocytes, smooth muscle , arachidonic acid , iloprost

Diabetes July 2005, Vol.54, 2155-2163. doi:https://doi.org/10.2337/diabetes.54.7.2155

The Early Natural History of Nephropathy in Type 1 Diabetes: III. Predictors of 5-Year Urinary Albumin Excretion Rate Patterns in Initially Normoalbuminuric Patients

Julia M. Steinke; Alan R. Sinaiko; Michael S. Kramer; Samy Suissa; Blanche M. Chavers; Michael Mauer; for the International Diabetic Nephropathy Study Group

Abstracts

View articletitled, The Early Natural History of Nephropathy in Type 1 Diabetes: III. Predictors of 5-Year Urinary Albumin Excretion Rate Patterns in Initially Normoalbuminuric Patients

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Topics: albumins , diabetes mellitus, type 1 , diabetic nephropathy , excretory function , glomerular filtration rate

Diabetes July 2005, Vol.54, 2164-2171. doi:https://doi.org/10.2337/diabetes.54.7.2164

Heparanase-1 Gene Expression and Regulation by High Glucose in Renal Epithelial Cells : A Potential Role in the Pathogenesis of Proteinuria in Diabetic Patients

Justin B. Maxhimer; Michael Somenek; Geetha Rao; Catherine E. Pesce; David Baldwin, Jr.; Paolo Gattuso; Melvin M. Schwartz; Edmund J. Lewis; Richard A. Prinz; Xiulong Xu

Abstract

View articletitled, Heparanase-1 Gene Expression and Regulation by High Glucose in Renal Epithelial Cells : A Potential Role in the Pathogenesis of Proteinuria in Diabetic Patients

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Topics: diabetic nephropathy , epithelial cells , glucose , kidney , kidney glomerulus

Diabetes July 2005, Vol.54, 2172-2178. doi:https://doi.org/10.2337/diabetes.54.7.2172

Metformin Prevents High-Glucose–Induced Endothelial Cell Death Through a Mitochondrial Permeability Transition-Dependent Process

Dominique Detaille; Bruno Guigas; Christiane Chauvin; Cécile Batandier; Eric Fontaine; Nicolas Wiernsperger; Xavier Leverve

Abstract

View articletitled, Metformin Prevents High-Glucose–Induced Endothelial Cell Death Through a Mitochondrial Permeability Transition-Dependent Process

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Topics: endothelial cells , glucose , metformin , cyclosporine , cytochrome c

Diabetes July 2005, Vol.54, 2179-2187. doi:https://doi.org/10.2337/diabetes.54.7.2179

The Effect of Ruboxistaurin on Visual Loss in Patients With Moderately Severe to Very Severe Nonproliferative Diabetic Retinopathy : Initial Results of the Protein Kinase C β Inhibitor Diabetic Retinopathy Study (PKC-DRS) Multicenter Randomized Clinical Trial

The PKC-DRS Study Group

Abstracts

View articletitled, The Effect of Ruboxistaurin on Visual Loss in Patients With Moderately Severe to Very Severe Nonproliferative Diabetic Retinopathy : Initial Results of the Protein Kinase C β Inhibitor Diabetic Retinopathy Study (PKC-DRS) Multicenter Randomized Clinical Trial

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Topics: adverse event , blindness , diabetic retinopathy , eye , light coagulation

Diabetes July 2005, Vol.54, 2188-2197. doi:https://doi.org/10.2337/diabetes.54.7.2188

Advanced Glycation End Product Precursors Impair ABCA1-Dependent Cholesterol Removal From Cells

Marisa Passarelli; Chongren Tang; Thomas O. McDonald; Kevin D. O’Brien; Ross G. Gerrity; Jay W. Heinecke; John F. Oram

Abstract

View articletitled, Advanced Glycation End Product Precursors Impair ABCA1-Dependent Cholesterol Removal From Cells

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Topics: abca1 gene , apolipoprotein a-i , cholesterol , macrophages

Diabetes July 2005, Vol.54, 2198-2205. doi:https://doi.org/10.2337/diabetes.54.7.2198

Rosiglitazone Improves Glomerular Hyperfiltration, Renal Endothelial Dysfunction, and Microalbuminuria of Incipient Diabetic Nephropathy in Patients

Frank Pistrosch; Kay Herbrig; Beate Kindel; Jens Passauer; Sabine Fischer; Peter Gross

Abstracts

View articletitled, Rosiglitazone Improves Glomerular Hyperfiltration, Renal Endothelial Dysfunction, and Microalbuminuria of Incipient Diabetic Nephropathy in Patients

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Topics: diabetic nephropathy , endothelial dysfunction , glomerular filtration rate , kidney , kidney glomerulus

Diabetes July 2005, Vol.54, 2206-2211. doi:https://doi.org/10.2337/diabetes.54.7.2206

Pharmacology and Therapeutics

Erythromycin Antagonizes the Deceleration of Gastric Emptying by Glucagon-Like Peptide 1 and Unmasks Its Insulinotropic Effect in Healthy Subjects

Juris J. Meier; Guido Kemmeries; Jens J. Holst; Michael A. Nauck

Abstract

View articletitled, Erythromycin Antagonizes the Deceleration of Gastric Emptying by Glucagon-Like Peptide 1 and Unmasks Its Insulinotropic Effect in Healthy Subjects

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Topics: erythromycin , gastric emptying , glucagon-like peptide 1 , insulin

Diabetes July 2005, Vol.54, 2212-2218. doi:https://doi.org/10.2337/diabetes.54.7.2212

Tempol Reduces Oxidative Stress, Improves Insulin Sensitivity, Decreases Renal Dopamine D1 Receptor Hyperphosphorylation, and Restores D1 Receptor–G-Protein Coupling and Function in Obese Zucker Rats

Anees Ahmad Banday; Aditi Marwaha; Lakshmi S. Tallam; Mustafa F. Lokhandwala

Abstracts

View articletitled, Tempol Reduces Oxidative Stress, Improves Insulin Sensitivity, Decreases Renal Dopamine D1 Receptor Hyperphosphorylation, and Restores D1 Receptor–G-Protein Coupling and Function in Obese Zucker Rats

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Topics: dopamine d1 receptor , gtp-binding proteins , kidney , obesity , oxidative stress

Diabetes July 2005, Vol.54, 2219-2226. doi:https://doi.org/10.2337/diabetes.54.7.2219

Signaling Pathways Involved in Human Vascular Smooth Muscle Cell Proliferation and Matrix Metalloproteinase-2 Expression Induced by Leptin : Inhibitory Effect of Metformin

Ling Li; Jean-Claude Mamputu; Nicolas Wiernsperger; Geneviève Renier

Abstracts

View articletitled, Signaling Pathways Involved in Human Vascular Smooth Muscle Cell Proliferation and Matrix Metalloproteinase-2 Expression Induced by Leptin : Inhibitory Effect of Metformin

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Topics: gelatinase a , leptin , metformin

Diabetes July 2005, Vol.54, 2227-2234. doi:https://doi.org/10.2337/diabetes.54.7.2227

Long-Term Treatment With Rosiglitazone and Metformin Reduces the Extent of, but Does Not Prevent, Islet Amyloid Deposition in Mice Expressing the Gene for Human Islet Amyloid Polypeptide

Rebecca L. Hull; Zhen-Ping Shen; Melissah R. Watts; Keiichi Kodama; Darcy B. Carr; Kristina M. Utzschneider; Sakeneh Zraika; Feng Wang; Steven E. Kahn

Abstracts

View articletitled, Long-Term Treatment With Rosiglitazone and Metformin Reduces the Extent of, but Does Not Prevent, Islet Amyloid Deposition in Mice Expressing the Gene for Human Islet Amyloid Polypeptide

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Topics: amyloid , glucose , insulin , metformin , metformin/rosiglitazone

Diabetes July 2005, Vol.54, 2235-2244. doi:https://doi.org/10.2337/diabetes.54.7.2235

Brief Genetics Reports

Genetic Variation in Adiponectin Receptor 1 and Adiponectin Receptor 2 Is Associated With Type 2 Diabetes in the Old Order Amish

Coleen M. Damcott; Sandra H. Ott; Toni I. Pollin; Laurie J. Reinhart; Jian Wang; Jeffrey R. O’Connell; Braxton D. Mitchell; Alan R. Shuldiner

Abstracts

View articletitled, Genetic Variation in Adiponectin Receptor 1 and Adiponectin Receptor 2 Is Associated With Type 2 Diabetes in the Old Order Amish

Supplementary data

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Topics: diabetes mellitus, type 2 , receptors, adiponectin , single nucleotide polymorphism , sequence analysis , genetics

Diabetes July 2005, Vol.54, 2245-2250. doi:https://doi.org/10.2337/diabetes.54.7.2245

Hepatic Lipase Gene Variant −514C>T Is Associated With Lipoprotein and Insulin Sensitivity Response to Regular Exercise: The HERITAGE Family Study

Margarita Teran-Garcia; Nicola Santoro; Tuomo Rankinen; Jean Bergeron; Treva Rice; Arthur S. Leon; D.C. Rao; James S. Skinner; Richard N. Bergman; Jean-Pierre Després; Claude Bouchard

Abstract

View articletitled, Hepatic Lipase Gene Variant −514C>T Is Associated With Lipoprotein and Insulin Sensitivity Response to Regular Exercise: The HERITAGE Family Study

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Topics: chief complaint , genes , genotype , hepatic lipase , lipoprotein lipase

Diabetes July 2005, Vol.54, 2251-2255. doi:https://doi.org/10.2337/diabetes.54.7.2251

Polymorphisms in the SLC2A2 (GLUT2) Gene Are Associated With the Conversion From Impaired Glucose Tolerance to Type 2 Diabetes : The Finnish Diabetes Prevention Study

Olli Laukkanen; Jaana Lindström; Johan Eriksson; Timo T. Valle; Helena Hämäläinen; Pirjo Ilanne-Parikka; Sirkka Keinänen-Kiukaanniemi; Jaakko Tuomilehto; Matti Uusitupa; Markku Laakso

Abstract

View articletitled, Polymorphisms in the SLC2A2 (GLUT2) Gene Are Associated With the Conversion From Impaired Glucose Tolerance to Type 2 Diabetes : The Finnish Diabetes Prevention Study

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Topics: diabetes mellitus, type 2 , genes , glucose intolerance , single nucleotide polymorphism , diabetes prevention

Diabetes July 2005, Vol.54, 2256-2260. doi:https://doi.org/10.2337/diabetes.54.7.2256

Evidence of an Association Between the Arg72 Allele of the Peptide YY and Increased Risk of Type 2 Diabetes

Signe S. Torekov; Lesli H. Larsen; Charlotte Glümer; Knut Borch-Johnsen; Torben Jørgensen; Jens J. Holst; Ole D. Madsen; Torben Hansen; Oluf Pedersen

Abstracts

View articletitled, Evidence of an Association Between the Arg72 Allele of the Peptide YY and Increased Risk of Type 2 Diabetes

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Topics: diabetes mellitus, type 2 , glucose , obesity , overweight , alleles

Diabetes July 2005, Vol.54, 2261-2265. doi:https://doi.org/10.2337/diabetes.54.7.2261

Retraction

Franz M. Matschinsky

Extract

View articletitled, Retraction

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Topics: glucose , insulin , interstitial fluid , obesity

Diabetes July 2005, Vol.54, 2266. doi:https://doi.org/10.2337/diabetes.54.7.2266

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