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Issues
1 August 2005
ISSN 0012-1797
EISSN 1939-327X
Obesity Studies
Proopiomelanocortin-Deficient Mice Are Hypersensitive to the Adverse Metabolic Effects of Glucocorticoids
Diabetes August 2005, Vol.54, 2269-2276. doi:https://doi.org/10.2337/diabetes.54.8.2269
Reduction of Macrophage Infiltration and Chemoattractant Gene Expression Changes in White Adipose Tissue of Morbidly Obese Subjects After Surgery-Induced Weight Loss
Raffaella Cancello; Corneliu Henegar; Nathalie Viguerie; Soraya Taleb; Christine Poitou; Christine Rouault; Muriel Coupaye; Veronique Pelloux; Danielle Hugol; Jean-Luc Bouillot; Anne Bouloumié; Giorgio Barbatelli; Saverio Cinti; Per-Arne Svensson; Gregory S. Barsh; Jean-Daniel Zucker; Arnaud Basdevant; Dominique Langin; Karine Clément
Diabetes August 2005, Vol.54, 2277-2286. doi:https://doi.org/10.2337/diabetes.54.8.2277
β-Cell Function in Morbidly Obese Subjects During Free Living : Long-Term Effects of Weight Loss
Stefania Camastra; Melania Manco; Andrea Mari; Simona Baldi; Amalia Gastaldelli; Aldo V. Greco; Gertrude Mingrone; Ele Ferrannini
Diabetes August 2005, Vol.54, 2382-2389. doi:https://doi.org/10.2337/diabetes.54.8.2382
Subcutaneous Oxyntomodulin Reduces Body Weight in Overweight and Obese Subjects: A Double-Blind, Randomized, Controlled Trial
Katie Wynne; Adrian J. Park; Caroline J. Small; Michael Patterson; Sandra M. Ellis; Kevin G. Murphy; Alison M. Wren; Gary S. Frost; Karim Meeran; Mohammad A. Ghatei; Stephen R. Bloom
Diabetes August 2005, Vol.54, 2390-2395. doi:https://doi.org/10.2337/diabetes.54.8.2390
Immunology and Transplantation
Donor Islet Endothelial Cells Participate in Formation of Functional Vessels Within Pancreatic Islet Grafts
Diabetes August 2005, Vol.54, 2287-2293. doi:https://doi.org/10.2337/diabetes.54.8.2287
Disruption of the γ-Interferon Signaling Pathway at the Level of Signal Transducer and Activator of Transcription-1 Prevents Immune Destruction of β-cells
Conny A. Gysemans; Laurence Ladrière; Hanne Callewaert; Joanne Rasschaert; Daisy Flamez; David E. Levy; Patrick Matthys; Décio L. Eizirik; Chantal Mathieu
Diabetes August 2005, Vol.54, 2396-2403. doi:https://doi.org/10.2337/diabetes.54.8.2396
Islet Studies
Mechanisms of Compensatory β-Cell Growth in Insulin-Resistant Rats : Roles of Akt Kinase
Thomas L. Jetton; James Lausier; Kyla LaRock; Winifred E. Trotman; Brooke Larmie; Aida Habibovic; Mina Peshavaria; Jack L. Leahy
Diabetes August 2005, Vol.54, 2294-2304. doi:https://doi.org/10.2337/diabetes.54.8.2294
Pathophysiology
Expression of CD68 and Macrophage Chemoattractant Protein-1 Genes in Human Adipose and Muscle Tissues: Association With Cytokine Expression, Insulin Resistance, and Reduction by Pioglitazone
Gina B. Di Gregorio; Aiwei Yao-Borengasser; Neda Rasouli; Vijayalakshmi Varma; Tong Lu; Leslie M. Miles; Gouri Ranganathan; Charlotte A. Peterson; Robert E. McGehee; Philip A. Kern
Diabetes August 2005, Vol.54, 2305-2313. doi:https://doi.org/10.2337/diabetes.54.8.2305
Insulin Resistance and Type 2 Diabetes in High-Fat–Fed Mice Are Linked to High Glycotoxin Intake
Diabetes August 2005, Vol.54, 2314-2319. doi:https://doi.org/10.2337/diabetes.54.8.2314
Complications
Carnosine as a Protective Factor in Diabetic Nephropathy: Association With a Leucine Repeat of the Carnosinase Gene CNDP1
Bart Janssen; Daniela Hohenadel; Paul Brinkkoetter; Verena Peters; Nina Rind; Christine Fischer; Ivan Rychlik; Marie Cerna; Marianna Romzova; Emile de Heer; Hans Baelde; Stephan J.L. Bakker; Mahmoud Zirie; Eric Rondeau; Peter Mathieson; Moin A. Saleem; Jochen Meyer; Hannes Köppel; Sibylle Sauerhoefer; Claus R. Bartram; Peter Nawroth; Hans-Peter Hammes; Benito A. Yard; Johannes Zschocke; Fokko J. van der Woude
Diabetes August 2005, Vol.54, 2320-2327. doi:https://doi.org/10.2337/diabetes.54.8.2320
Regulation of Renal Lipid Metabolism, Lipid Accumulation, and Glomerulosclerosis in FVBdb/db Mice With Type 2 Diabetes
Zhuowei Wang; Tao Jiang; Jinping Li; Gregory Proctor; James L. McManaman; Scott Lucia; Streamson Chua; Moshe Levi
Diabetes August 2005, Vol.54, 2328-2335. doi:https://doi.org/10.2337/diabetes.54.8.2328
Compromised Arterial Function in Human Type 2 Diabetic Patients
Elena B. Okon; Ada W.Y. Chung; Pooja Rauniyar; Eugenia Padilla; Teresa Tejerina; Bruce M. McManus; Honglin Luo; Cornelis van Breemen
Diabetes August 2005, Vol.54, 2415-2423. doi:https://doi.org/10.2337/diabetes.54.8.2415
3,4-Dideoxyglucosone-3-ene Induces Apoptosis in Renal Tubular Epithelial Cells
Diabetes August 2005, Vol.54, 2424-2429. doi:https://doi.org/10.2337/diabetes.54.8.2424
Platelet Function Profiles in Patients With Type 2 Diabetes and Coronary Artery Disease on Combined Aspirin and Clopidogrel Treatment
Dominick J. Angiolillo; Antonio Fernandez-Ortiz; Esther Bernardo; Celia Ramírez; Manel Sabaté; Pilar Jimenez-Quevedo; Rosana Hernández; Raul Moreno; Javier Escaned; Fernando Alfonso; Camino Bañuelos; Marco A. Costa; Theodore A. Bass; Carlos Macaya
Diabetes August 2005, Vol.54, 2430-2435. doi:https://doi.org/10.2337/diabetes.54.8.2430
Genetics
Association of Common Variation in the HNF1α Gene Region With Risk of Type 2 Diabetes
Wendy Winckler; Noël P. Burtt; Johan Holmkvist; Camilla Cervin; Paul I.W. de Bakker; Maria Sun; Peter Almgren; Tiinamaija Tuomi; Daniel Gaudet; Thomas J. Hudson; Kristin G. Ardlie; Mark J. Daly; Joel N. Hirschhorn; David Altshuler; Leif Groop
Diabetes August 2005, Vol.54, 2336-2342. doi:https://doi.org/10.2337/diabetes.54.8.2336
Metabolism
Physiological Increases in Uncoupling Protein 3 Augment Fatty Acid Oxidation and Decrease Reactive Oxygen Species Production Without Uncoupling Respiration in Muscle Cells
J. Darcy MacLellan; Martin F. Gerrits; Adrienne Gowing; Peter J.S. Smith; Michael B. Wheeler; Mary-Ellen Harper
Diabetes August 2005, Vol.54, 2343-2350. doi:https://doi.org/10.2337/diabetes.54.8.2343
Signal Transduction
Increased p85/55/50 Expression and Decreased Phosphotidylinositol 3-Kinase Activity in Insulin-Resistant Human Skeletal Muscle
Diabetes August 2005, Vol.54, 2351-2359. doi:https://doi.org/10.2337/diabetes.54.8.2351
Preconditioning the Diabetic Heart : The Importance of Akt Phosphorylation
Diabetes August 2005, Vol.54, 2360-2364. doi:https://doi.org/10.2337/diabetes.54.8.2360
Skeletal Muscle AMP-Activated Protein Kinase Phosphorylation Parallels Metabolic Phenotype in Leptin Transgenic Mice Under Dietary Modification
Tomohiro Tanaka; Shuji Hidaka; Hiroaki Masuzaki; Shintaro Yasue; Yasuhiko Minokoshi; Ken Ebihara; Hideki Chusho; Yoshihiro Ogawa; Taro Toyoda; Kenji Sato; Fumiko Miyanaga; Muneya Fujimoto; Tsutomu Tomita; Toru Kusakabe; Nozomi Kobayashi; Hideki Tanioka; Tatsuya Hayashi; Kiminori Hosoda; Hironobu Yoshimatsu; Toshiie Sakata; Kazuwa Nakao
Diabetes August 2005, Vol.54, 2365-2374. doi:https://doi.org/10.2337/diabetes.54.8.2365
Insulin and Inositol 1,4,5-Trisphosphate Trigger Abnormal Cytosolic Ca2+ Transients and Reveal Mitochondrial Ca2+ Handling Defects in Cardiomyocytes of ob/ob Mice
Jérémy Fauconnier; Johanna T. Lanner; Shi-Jin Zhang; Pasi Tavi; Joseph D. Bruton; Abram Katz; Håkan Westerblad
Diabetes August 2005, Vol.54, 2375-2381. doi:https://doi.org/10.2337/diabetes.54.8.2375
Pharmacology and Therapeutics
Chemical Ablation of Gastric Inhibitory Polypeptide Receptor Action by Daily (Pro3)GIP Administration Improves Glucose Tolerance and Ameliorates Insulin Resistance and Abnormalities of Islet Structure in Obesity-Related Diabetes
Victor A. Gault; Nigel Irwin; Brian D. Green; Jane T. McCluskey; Brett Greer; Clifford J. Bailey; Patrick Harriott; Finbarr P.M. O’Harte; Peter R. Flatt
Diabetes August 2005, Vol.54, 2436-2446. doi:https://doi.org/10.2337/diabetes.54.8.2436
Rosiglitazone Reduces Glucose-Stimulated Insulin Secretion Rate and Increases Insulin Clearance in Nondiabetic, Insulin-Resistant Individuals
Sun H. Kim; Fahim Abbasi; James W. Chu; Tracey L. McLaughlin; Cindy Lamendola; Kenneth S. Polonsky; Gerald M. Reaven
Diabetes August 2005, Vol.54, 2447-2452. doi:https://doi.org/10.2337/diabetes.54.8.2447
Therapeutic Roles of Peroxisome Proliferator–Activated Receptor Agonists
Diabetes August 2005, Vol.54, 2460-2470. doi:https://doi.org/10.2337/diabetes.54.8.2460
Galanin-Like Peptide Rescues Reproductive Function in the Diabetic Rat
Diabetes August 2005, Vol.54, 2471-2476. doi:https://doi.org/10.2337/diabetes.54.8.2471
Brief Genetics Reports
A Synonymous Coding Polymorphism in the α2-Heremans-Schmid Glycoprotein Gene Is Associated With Type 2 Diabetes in French Caucasians
Diabetes August 2005, Vol.54, 2477-2481. doi:https://doi.org/10.2337/diabetes.54.8.2477
Association of Non-HLA Genes With Type 1 Diabetes Autoimmunity
Andrea K. Steck; Teodorica L. Bugawan; Ana Maria Valdes; Lisa M. Emery; Alan Blair; Jill M. Norris; Maria J. Redondo; Sunanda R. Babu; Henry A. Erlich; George S. Eisenbarth; Marian J. Rewers
Diabetes August 2005, Vol.54, 2482-2486. doi:https://doi.org/10.2337/diabetes.54.8.2482
A Large-Scale Association Analysis of Common Variation of the HNF1α Gene With Type 2 Diabetes in the U.K. Caucasian Population
Michael N. Weedon; Katharine R. Owen; Beverley Shields; Graham Hitman; Mark Walker; Mark I. McCarthy; Andrew T. Hattersley; Timothy M. Frayling
Diabetes August 2005, Vol.54, 2487-2491. doi:https://doi.org/10.2337/diabetes.54.8.2487
Association Between Common Polymorphisms of the Proopiomelanocortin Gene and Body Fat Distribution: A Family Study
Michelle Baker; Nicole Gaukrodger; Bongani M. Mayosi; Helen Imrie; Martin Farrall; Hugh Watkins; John M.C. Connell; Peter J. Avery; Bernard Keavney
Diabetes August 2005, Vol.54, 2492-2496. doi:https://doi.org/10.2337/diabetes.54.8.2492
Tribute
Paul Eston Lacy, MD, PhD
Diabetes August 2005, Vol.54, 2497-2498. doi:https://doi.org/10.2337/diabetes.54.8.2497
