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Issues
1 September 2005
ISSN 0012-1797
EISSN 1939-327X
Perspectives in Diabetes
Activating Mutations in Kir6.2 and Neonatal Diabetes : New Clinical Syndromes, New Scientific Insights, and New Therapy
Diabetes September 2005, Vol.54, 2503-2513. doi:https://doi.org/10.2337/diabetes.54.9.2503
Signal Transduction
Cardiac-Specific Overexpression of Peroxisome Proliferator–Activated Receptor-α Causes Insulin Resistance in Heart and Liver
So-Young Park; You-Ree Cho; Brian N. Finck; Hyo-Jeong Kim; Takamasa Higashimori; Eun-Gyoung Hong; Mi-Kyung Lee; Cheryl Danton; Swati Deshmukh; Gary W. Cline; Julie J. Wu; Anton M. Bennett; Beverly Rothermel; April Kalinowski; Kerry S. Russell; Young-Bum Kim; Daniel P. Kelly; Jason K. Kim
Diabetes September 2005, Vol.54, 2514-2524. doi:https://doi.org/10.2337/diabetes.54.9.2514
Acute Bidirectional Manipulation of Muscle Glucose Uptake by In Vivo Electrotransfer of Constructs Targeting Glucose Transporter Genes
Mark E. Cleasby; Jonathan R. Davey; Tracie A. Reinten; Michael W. Graham; David E. James; Edward W. Kraegen; Gregory J. Cooney
Diabetes September 2005, Vol.54, 2702-2711. doi:https://doi.org/10.2337/diabetes.54.9.2702
Immunology and Transplantation
Novel Leptin Receptor Mutation in NOD/LtJ Mice Suppresses Type 1 Diabetes Progression: I. Pathophysiological Analysis
Chul-Ho Lee; Peter C. Reifsnyder; Jürgen K. Naggert; Clive Wasserfall; Mark A. Atkinson; Jing Chen; Edward H. Leiter
Diabetes September 2005, Vol.54, 2525-2532. doi:https://doi.org/10.2337/diabetes.54.9.2525
The X-Linked Inhibitor of Apoptosis Protein Enhances Survival of Murine Islet Allografts
Diabetes September 2005, Vol.54, 2533-2540. doi:https://doi.org/10.2337/diabetes.54.9.2533
XIAP Overexpression in Human Islets Prevents Early Posttransplant Apoptosis and Reduces the Islet Mass Needed to Treat Diabetes
Juliet A. Emamaullee; Ray V. Rajotte; Peter Liston; Robert G. Korneluk; Jonathan R.T. Lakey; A.M. James Shapiro; John F. Elliott
Diabetes September 2005, Vol.54, 2541-2548. doi:https://doi.org/10.2337/diabetes.54.9.2541
Interferon-α as a Mediator of Polyinosinic:Polycytidylic Acid–Induced Type 1 Diabetes
Devasenan Devendra; Jean Jasinski; Evie Melanitou; Maki Nakayama; Marcella Li; Brooke Hensley; Johanna Paronen; Hiroaki Moriyama; Dongmei Miao; George S. Eisenbarth; Edwin Liu
Diabetes September 2005, Vol.54, 2549-2556. doi:https://doi.org/10.2337/diabetes.54.9.2549
LEW.1WR1 Rats Develop Autoimmune Diabetes Spontaneously and in Response to Environmental Perturbation
John P. Mordes; Dennis L. Guberski; Jean H. Leif; Bruce A. Woda; Joan F. Flanagan; Dale L. Greiner; Edward H. Kislauskis; Rebecca S. Tirabassi
Diabetes September 2005, Vol.54, 2727-2733. doi:https://doi.org/10.2337/diabetes.54.9.2727
Islet Studies
Very Slow Turnover of β-Cells in Aged Adult Mice
Diabetes September 2005, Vol.54, 2557-2567. doi:https://doi.org/10.2337/diabetes.54.9.2557
Differentiation of Human Liver-Derived, Insulin-Producing Cells Toward the β-Cell Phenotype
Diabetes September 2005, Vol.54, 2568-2575. doi:https://doi.org/10.2337/diabetes.54.9.2568
Essential Role for Membrane Lipid Rafts in Interleukin-1β−Induced Nitric Oxide Release From Insulin-Secreting Cells: Potential Regulation by Caveolin-1+
Rajakrishnan Veluthakal; Irina Chvyrkova; Marie Tannous; Phillip McDonald; Rajesh Amin; Timothy Hadden; Debbie C. Thurmond; Michael J. Quon; Anjaneyulu Kowluru
Diabetes September 2005, Vol.54, 2576-2585. doi:https://doi.org/10.2337/diabetes.54.9.2576
Conditional Expression Demonstrates the Role of the Homeodomain Transcription Factor Pdx1 in Maintenance and Regeneration of β-Cells in the Adult Pancreas
Diabetes September 2005, Vol.54, 2586-2595. doi:https://doi.org/10.2337/diabetes.54.9.2586
Combination Therapy With Epidermal Growth Factor and Gastrin Increases β-Cell Mass and Reverses Hyperglycemia in Diabetic NOD Mice
Diabetes September 2005, Vol.54, 2596-2601. doi:https://doi.org/10.2337/diabetes.54.9.2596
Exposure to Chronic High Glucose Induces β-Cell Apoptosis Through Decreased Interaction of Glucokinase With Mitochondria: Downregulation of Glucokinase in Pancreatic β-Cells
Won-Ho Kim; June Woo Lee; Young Ho Suh; Shin Hee Hong; Joo Sun Choi; Joo Hyun Lim; Ji Hyun Song; Bin Gao; Myeong Ho Jung
Diabetes September 2005, Vol.54, 2602-2611. doi:https://doi.org/10.2337/diabetes.54.9.2602
Matrix Metalloproteinases Contribute to Insulin Insufficiency in Zucker Diabetic Fatty Rats
Yun-Ping Zhou; Azadeh Madjidi; Maria E. Wilson; David A. Nothhelfer; John H. Johnson; John F. Palma; Anthony Schweitzer; Charles Burant; John E. Blume; Jeffrey D. Johnson
Diabetes September 2005, Vol.54, 2612-2619. doi:https://doi.org/10.2337/diabetes.54.9.2612
Glucagon-Like Peptide 1 Regulates Sequential and Compound Exocytosis in Pancreatic Islet β-Cells
Diabetes September 2005, Vol.54, 2734-2743. doi:https://doi.org/10.2337/diabetes.54.9.2734
Transgenic Mouse Overexpressing Syntaxin-1A as a Diabetes Model
Patrick P.L. Lam; Yuk-Man Leung; Laura Sheu; James Ellis; Robert G. Tsushima; Lucy R. Osborne; Herbert Y. Gaisano
Diabetes September 2005, Vol.54, 2744-2754. doi:https://doi.org/10.2337/diabetes.54.9.2744
Pathophysiology
Marked Increase in White Adipose Tissue Blood Perfusion in the Type 2 Diabetic GK Rat
Diabetes September 2005, Vol.54, 2620-2627. doi:https://doi.org/10.2337/diabetes.54.9.2620
Experimental Diabetes Attenuates Cerebral Cortical−Evoked Forelimb Motor Responses
Diabetes September 2005, Vol.54, 2764-2771. doi:https://doi.org/10.2337/diabetes.54.9.2764
Adiponectin Is Lower Among African Americans and Is Independently Related to Insulin Sensitivity in Children and Adolescents
Diabetes September 2005, Vol.54, 2772-2778. doi:https://doi.org/10.2337/diabetes.54.9.2772
Activation of Peripheral Blood CD14+ Monocytes Occurs in Diabetes
Diabetes September 2005, Vol.54, 2779-2786. doi:https://doi.org/10.2337/diabetes.54.9.2779
Complications
Characterization of Susceptibility of Inbred Mouse Strains to Diabetic Nephropathy
Zhonghua Qi; Hiroki Fujita; Jianping Jin; Linda S. Davis; Yihan Wang; Agnes B. Fogo; Matthew D. Breyer
Diabetes September 2005, Vol.54, 2628-2637. doi:https://doi.org/10.2337/diabetes.54.9.2628
Type 2 Diabetes Causes Remodeling of Cerebrovasculature via Differential Regulation of Matrix Metalloproteinases and Collagen Synthesis : Role of Endothelin-1
Alex K. Harris; Jim R. Hutchinson; Kamakshi Sachidanandam; Maribeth H. Johnson; Anne M. Dorrance; David W. Stepp; Susan C. Fagan; Adviye Ergul
Diabetes September 2005, Vol.54, 2638-2644. doi:https://doi.org/10.2337/diabetes.54.9.2638
Genetics
ATP and Sulfonylurea Sensitivity of Mutant ATP-Sensitive K+ Channels in Neonatal Diabetes: Implications for Pharmacogenomic Therapy
Diabetes September 2005, Vol.54, 2645-2654. doi:https://doi.org/10.2337/diabetes.54.9.2645
Genome-Wide Linkage Analyses of Type 2 Diabetes in Mexican Americans: The San Antonio Family Diabetes/Gallbladder Study
Kelly J. Hunt; Donna M. Lehman; Rector Arya; Sharon Fowler; Robin J. Leach; Harald H.H. Göring; Laura Almasy; John Blangero; Tom D. Dyer; Ravindranath Duggirala; Michael P. Stern
Diabetes September 2005, Vol.54, 2655-2662. doi:https://doi.org/10.2337/diabetes.54.9.2655
Variation in the eNOS Gene Modifies the Association Between Total Energy Expenditure and Glucose Intolerance
Paul W. Franks; Jian’an Luan; Inês Barroso; Søren Brage; Jose Luis Gonzalez Sanchez; Ulf Ekelund; Manuel Serrano Ríos; Alan J. Schafer; Stephen O’Rahilly; Nicholas J. Wareham
Diabetes September 2005, Vol.54, 2795-2801. doi:https://doi.org/10.2337/diabetes.54.9.2795
Brief Genetics Reports
Co-occurrence of Two Partially Inactivating Polymorphisms of MC3R Is Associated With Pediatric-Onset Obesity
Ningping Feng; Sharla F. Young; Greti Aguilera; Elena Puricelli; Diane C. Adler-Wailes; Nancy G. Sebring; Jack A. Yanovski
Diabetes September 2005, Vol.54, 2663-2667. doi:https://doi.org/10.2337/diabetes.54.9.2663
Haptoglobin Polymorphism Predicts 30-Day Mortality and Heart Failure in Patients With Diabetes and Acute Myocardial Infarction
Mahmoud Suleiman; Doron Aronson; Rabea Asleh; Michael R. Kapeliovich; Ariel Roguin; Simcha R. Meisel; Michael Shochat; Abeer Sulieman; Shimon A. Reisner; Walter Markiewicz; Haim Hammerman; Rachel Lotan; Nina S. Levy; Andrew P. Levy
Diabetes September 2005, Vol.54, 2802-2806. doi:https://doi.org/10.2337/diabetes.54.9.2802
The Functional Q84R Polymorphism of Mammalian Tribbles Homolog TRB3 Is Associated With Insulin Resistance and Related Cardiovascular Risk in Caucasians From Italy
Sabrina Prudente; Marta Letizia Hribal; Elisabetta Flex; Federica Turchi; Eleonora Morini; Salvatore De Cosmo; Simonetta Bacci; Vittorio Tassi; Marina Cardellini; Renato Lauro; Giorgio Sesti; Bruno Dallapiccola; Vincenzo Trischitta
Diabetes September 2005, Vol.54, 2807-2811. doi:https://doi.org/10.2337/diabetes.54.9.2807
INS VNTR Class Genotype and Indexes of Body Size and Obesity : Population-Based Studies of 7,999 Middle-Aged Men and Women
Manjinder S. Sandhu; Barbara Heude; Elizabeth H. Young; Robert Luben; Jian’an Luan; Kay-Tee Khaw; John Todd; Nicholas J. Wareham
Diabetes September 2005, Vol.54, 2812-2815. doi:https://doi.org/10.2337/diabetes.54.9.2812
Lack of Association of PAX4 Gene With Type 1 Diabetes in the Finnish and Hungarian Populations
Robert Hermann; Jussi Mantere; Kati Lipponen; Riitta Veijola; Gyula Soltesz; Timo Otonkoski; Olli Simell; Mikael Knip; Jorma Ilonen
Diabetes September 2005, Vol.54, 2816-2819. doi:https://doi.org/10.2337/diabetes.54.9.2816
Colocalization of Mouse Autoimmune Diabetes Loci Idd21.1 and Idd21.2 With IDDM6 (Human) and Iddm3 (Rat)
Diabetes September 2005, Vol.54, 2820-2825. doi:https://doi.org/10.2337/diabetes.54.9.2820
Metabolism
Spillover of Dietary Fatty Acids and Use of Serum Nonesterified Fatty Acids for the Synthesis of VLDL-Triacylglycerol Under Two Different Feeding Regimens
Diabetes September 2005, Vol.54, 2668-2673. doi:https://doi.org/10.2337/diabetes.54.9.2668
Overactivation of S6 Kinase 1 as a Cause of Human Insulin Resistance During Increased Amino Acid Availability
Frédéric Tremblay; Michael Krebs; Luce Dombrowski; Attila Brehm; Elisabeth Bernroider; Erich Roth; Peter Nowotny; Werner Waldhäusl; André Marette; Michael Roden
Diabetes September 2005, Vol.54, 2674-2684. doi:https://doi.org/10.2337/diabetes.54.9.2674
Expression of Mfn2, the Charcot-Marie-Tooth Neuropathy Type 2A Gene, in Human Skeletal Muscle : Effects of Type 2 Diabetes, Obesity, Weight Loss, and the Regulatory Role of Tumor Necrosis Factor α and Interleukin-6
Daniel Bach; Deborah Naon; Sara Pich; Francesc X. Soriano; Nathalie Vega; Jennifer Rieusset; Martine Laville; Christelle Guillet; Yves Boirie; Harriet Wallberg-Henriksson; Melania Manco; Menotti Calvani; Marco Castagneto; Manuel Palacín; Geltrude Mingrone; Juleen R. Zierath; Hubert Vidal; Antonio Zorzano
Diabetes September 2005, Vol.54, 2685-2693. doi:https://doi.org/10.2337/diabetes.54.9.2685
Increased Dietary Substrate Delivery Alters Hepatic Fatty Acid Recycling in Healthy Men
Diabetes September 2005, Vol.54, 2694-2701. doi:https://doi.org/10.2337/diabetes.54.9.2694
Obesity Studies
Changes of Adiponectin Oligomer Composition by Moderate Weight Reduction
Thomas Bobbert; Helmut Rochlitz; Uta Wegewitz; Suzan Akpulat; Knut Mai; Martin O. Weickert; Matthias Möhlig; Andreas F.H. Pfeiffer; Joachim Spranger
Diabetes September 2005, Vol.54, 2712-2719. doi:https://doi.org/10.2337/diabetes.54.9.2712
Increased Fat Mass Compensates for Insulin Resistance in Abdominal Obesity and Type 2 Diabetes : A Positron-Emitting Tomography Study
Kirsi A. Virtanen; Patricia Iozzo; Kirsti Hällsten; Risto Huupponen; Riitta Parkkola; Tuula Janatuinen; Fredrik Lönnqvist; Tapio Viljanen; Tapani Rönnemaa; Peter Lönnroth; Juhani Knuuti; Ele Ferrannini; Pirjo Nuutila
Diabetes September 2005, Vol.54, 2720-2726. doi:https://doi.org/10.2337/diabetes.54.9.2720
Pharmacology & Therapeutics
Rosiglitazone Improves Myocardial Glucose Uptake in Patients With Type 2 Diabetes and Coronary Artery Disease : A 16-Week Randomized, Double-Blind, Placebo-Controlled Study
Riikka Lautamäki; K.E. Juhani Airaksinen; Marko Seppänen; Jyri Toikka; Matti Luotolahti; Elizabeth Ball; Ronald Borra; Risto Härkönen; Patricia Iozzo; Murray Stewart; Juhani Knuuti; Pirjo Nuutila
Diabetes September 2005, Vol.54, 2787-2794. doi:https://doi.org/10.2337/diabetes.54.9.2787
