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Issues
Perspectives in Diabetes
The Network of Glucokinase-Expressing Cells in Glucose Homeostasis and the Potential of Glucokinase Activators for Diabetes Therapy
Franz M. Matschinsky; Mark A. Magnuson; Dorothy Zelent; Tom L. Jetton; Nicolai Doliba; Yi Han; Rebecca Taub; Joseph Grimsby
Diabetes January 2006, Vol.55, 1-12. doi:https://doi.org/10.2337/diabetes.55.01.06.db05-0926
New Methodology and Database
Noninvasive Diagnosis of Focal Hyperinsulinism of Infancy With [18F]-DOPA Positron Emission Tomography
Timo Otonkoski; Kirsti Näntö-Salonen; Marko Seppänen; Riitta Veijola; Hanna Huopio; Khalid Hussain; Päivi Tapanainen; Olli Eskola; Riitta Parkkola; Klas Ekström; Yves Guiot; Jacques Rahier; Markku Laakso; Risto Rintala; Pirjo Nuutila; Heikki Minn
Diabetes January 2006, Vol.55, 13-18. doi:https://doi.org/10.2337/diabetes.55.01.06.db05-1128
Obesity Studies
Y2Y4 Receptor Double Knockout Protects Against Obesity Due to a High-Fat Diet or Y1 Receptor Deficiency in Mice
Amanda Sainsbury; Hugo T. Bergen; Dana Boey; Darja Bamming; Gregory J. Cooney; Shu Lin; Michelle Couzens; Nikolas Stroth; Nicola J. Lee; Diana Lindner; Nicolas Singewald; Tim Karl; Liesl Duffy; Ronaldo Enriquez; Katy Slack; Günther Sperk; Herbert Herzog
Diabetes January 2006, Vol.55, 19-26. doi:https://doi.org/10.2337/diabetes.55.01.06.db05-0472
Adiponectin Does Not Cross the Blood-Brain Barrier but Modifies Cytokine Expression of Brain Endothelial Cells
Joachim Spranger; Sulekha Verma; Isabel Göhring; Thomas Bobbert; Joseph Seifert; Amy L. Sindler; Andreas Pfeiffer; Stanley M. Hileman; Matthias Tschöp; William A. Banks
Diabetes January 2006, Vol.55, 141-147. doi:https://doi.org/10.2337/diabetes.55.01.06.db05-1077
Adipose Triglyceride Lipase: Function, Regulation by Insulin, and Comparison With Adiponutrin
Diabetes January 2006, Vol.55, 148-157. doi:https://doi.org/10.2337/diabetes.55.01.06.db05-0982
Immunology and Transplantation
Costimulation Blockade of Both Inducible Costimulator and CD40 Ligand Induces Dominant Tolerance to Islet Allografts and Prevents Spontaneous Autoimmune Diabetes in the NOD Mouse
Sulaiman A. Nanji; Wayne W. Hancock; Bin Luo; Colleen D. Schur; Rena L. Pawlick; Lin Fu Zhu; Colin C. Anderson; A.M. James Shapiro
Diabetes January 2006, Vol.55, 27-33. doi:https://doi.org/10.2337/diabetes.55.01.06.db04-1154
Natural Killer T-Cells Participate in Rejection of Islet Allografts in the Liver of Mice
Atsushi Toyofuku; Yohichi Yasunami; Kentaroh Nabeyama; Masahiko Nakano; Masayuki Satoh; Nobuhide Matsuoka; Junko Ono; Toshinori Nakayama; Masaru Taniguchi; Masao Tanaka; Seiyo Ikeda
Diabetes January 2006, Vol.55, 34-39. doi:https://doi.org/10.2337/diabetes.55.01.06.db05-0692
Rapamycin and Interleukin-10 Treatment Induces T Regulatory Type 1 Cells That Mediate Antigen-Specific Transplantation Tolerance
Manuela Battaglia; Angela Stabilini; Elena Draghici; Silvia Gregori; Cristina Mocchetti; Ezio Bonifacio; Maria-Grazia Roncarolo
Diabetes January 2006, Vol.55, 40-49. doi:https://doi.org/10.2337/diabetes.55.01.06.db05-0613
Coexpression of CD25 and OX40 (CD134) Receptors Delineates Autoreactive T-cells in Type 1 Diabetes
Josef Endl; Silke Rosinger; Barbara Schwarz; Sven-Olaf Friedrich; Gregor Rothe; Wolfram Karges; Michael Schlosser; Thomas Eiermann; Dolores J. Schendel; Bernhard O. Boehm
Diabetes January 2006, Vol.55, 50-60. doi:https://doi.org/10.2337/diabetes.55.01.06.db05-0387
Interleukin-7 Is a Survival Factor for CD4+ CD25+ T-Cells and Is Expressed by Diabetes-Suppressive Dendritic Cells
Jo Harnaha; Jennifer Machen; Marietta Wright; Robert Lakomy; Alexis Styche; Massimo Trucco; Sami Makaroun; Nick Giannoukakis
Diabetes January 2006, Vol.55, 158-170. doi:https://doi.org/10.2337/diabetes.55.01.06.db05-0340
Novel Leptin Receptor Mutation in NOD/LtJ Mice Suppresses Type 1 Diabetes Progression: II. Immunologic Analysis
Chul-Ho Lee; Yi-Guang Chen; Jing Chen; Peter C. Reifsnyder; David V. Serreze; Michael Clare-Salzler; Michelle Rodriguez; Clive Wasserfall; Mark A. Atkinson; Edward H. Leiter
Diabetes January 2006, Vol.55, 171-178. doi:https://doi.org/10.2337/diabetes.55.01.06.db05-1129
Transforming Growth Factor-β and Natural Killer T-Cells Are Involved in the Protective Effect of a Bacterial Extract on Type 1 Diabetes
Marie-Alexandra Alyanakian; Françoise Grela; Aude Aumeunier; Carlo Chiavaroli; Christine Gouarin; Emilie Bardel; Gérard Normier; Lucienne Chatenoud; Nathalie Thieblemont; Jean-François Bach
Diabetes January 2006, Vol.55, 179-185. doi:https://doi.org/10.2337/diabetes.55.01.06.db05-0189
The Diabetes Type 1 Locus Idd6 Modulates Activity of CD4+CD25+ Regulatory T-Cells
Ute Christine Rogner; Françoise Lepault; Marie-Claude Gagnerault; David Vallois; Joëlle Morin; Philip Avner; Christian Boitard
Diabetes January 2006, Vol.55, 186-192. doi:https://doi.org/10.2337/diabetes.55.01.06.db05-0598
Islet Studies
A vHNF1/TCF2-HNF6 Cascade Regulates the Transcription Factor Network That Controls Generation of Pancreatic Precursor Cells
Aurélie V. Poll; Christophe E. Pierreux; Ludmilla Lokmane; Cécile Haumaitre; Younes Achouri; Patrick Jacquemin; Guy G. Rousseau; Silvia Cereghini; Frédéric P. Lemaigre
Diabetes January 2006, Vol.55, 61-69. doi:https://doi.org/10.2337/diabetes.55.01.06.db05-0681
Evaluation of β-Cell Replication in Mice Transgenic for Hepatocyte Growth Factor and Placental Lactogen: Comprehensive Characterization of the G1/S Regulatory Proteins Reveals Unique Involvement of p21cip
Irene Cozar-Castellano; Matthew Weinstock; Marcia Haught; Silvia Velázquez-Garcia; Darinka Sipula; Andrew F. Stewart
Diabetes January 2006, Vol.55, 70-77. doi:https://doi.org/10.2337/diabetes.55.01.06.db05-0632
Glibenclamide Treatment Recruits β-Cell Subpopulation Into Elevated and Sustained Basal Insulin Synthetic Activity
Diabetes January 2006, Vol.55, 78-85. doi:https://doi.org/10.2337/diabetes.55.01.06.db05-0820
Leucine Regulation of Glucokinase and ATP Synthase Sensitizes Glucose-Induced Insulin Secretion in Pancreatic β-Cells
Jichun Yang; Ryan K. Wong; MieJung Park; Jianmei Wu; Joshua R. Cook; David A. York; Shaoping Deng; James Markmann; Ali Naji; Bryan A. Wolf; Zhiyong Gao
Diabetes January 2006, Vol.55, 193-201. doi:https://doi.org/10.2337/diabetes.55.01.06.db05-0938
Complications
Glucosamine-Induced Endoplasmic Reticulum Dysfunction Is Associated With Accelerated Atherosclerosis in a Hyperglycemic Mouse Model
Geoff H. Werstuck; Mohammad I. Khan; Giuseppe Femia; Anna J. Kim; Vivienne Tedesco; Bernardo Trigatti; Yuanyuan Shi
Diabetes January 2006, Vol.55, 93-101. doi:https://doi.org/10.2337/diabetes.55.01.06.db05-0633
Nitric Oxide Cytoskeletal–Induced Alterations Reverse the Endothelial Progenitor Cell Migratory Defect Associated With Diabetes
Mark S. Segal; Ronak Shah; Aqeela Afzal; Cecile M. Perrault; Kyunghee Chang; Anna Schuler; Elaine Beem; Lynn C. Shaw; Sergio Li Calzi; Jeffrey K. Harrison; Roger Tran-Son-Tay; Maria B. Grant
Diabetes January 2006, Vol.55, 102-109. doi:https://doi.org/10.2337/diabetes.55.01.06.db05-0803
The Thromboxane Receptor Antagonist S18886 Attenuates Renal Oxidant Stress and Proteinuria in Diabetic Apolipoprotein E-Deficient Mice
Shanqin Xu; Bingbing Jiang; Karlene A. Maitland; Hossein Bayat; Jiali Gu; Jerry L. Nadler; Stefano Corda; Gilbert Lavielle; Tony J. Verbeuren; Adriana Zuccollo; Richard A. Cohen
Diabetes January 2006, Vol.55, 110-119. doi:https://doi.org/10.2337/diabetes.55.01.06.db05-0831
Activation of AMP-Activated Protein Kinase Reduces Hyperglycemia-Induced Mitochondrial Reactive Oxygen Species Production and Promotes Mitochondrial Biogenesis in Human Umbilical Vein Endothelial Cells
Daisuke Kukidome; Takeshi Nishikawa; Kazuhiro Sonoda; Koujiro Imoto; Kazuo Fujisawa; Miyuki Yano; Hiroyuki Motoshima; Tetsuya Taguchi; Takeshi Matsumura; Eiichi Araki
Diabetes January 2006, Vol.55, 120-127. doi:https://doi.org/10.2337/diabetes.55.01.06.db05-0943
Glucose-Induced Reactive Oxygen Species Cause Apoptosis of Podocytes and Podocyte Depletion at the Onset of Diabetic Nephropathy
Diabetes January 2006, Vol.55, 225-233. doi:https://doi.org/10.2337/diabetes.55.01.06.db05-0894
Increased Renal Arterial Resistance Predicts the Course of Renal Function in Type 2 Diabetes With Microalbuminuria
Romano Nosadini; Mario Velussi; Enrico Brocco; Cataldo Abaterusso; Andrea Carraro; Francesco Piarulli; Giuseppe Morgia; Andrea Satta; Rossana Faedda; Avinash Abhyankar; Holgher Luthman; Giancarlo Tonolo
Diabetes January 2006, Vol.55, 234-239. doi:https://doi.org/10.2337/diabetes.55.01.06.db05-0881
Brief Genetics Reports
High-Density Haplotype Structure and Association Testing of the Insulin-Degrading Enzyme (IDE) Gene With Type 2 Diabetes in 4,206 People
Jose C. Florez; Steven Wiltshire; Christina M. Agapakis; Noël P. Burtt; Paul I.W. de Bakker; Peter Almgren; Kristina Bengtsson Boström; Tiinamaija Tuomi; Daniel Gaudet; Mark J. Daly; Joel N. Hirschhorn; Mark I. McCarthy; David Altshuler; Leif Groop
Diabetes January 2006, Vol.55, 128-135. doi:https://doi.org/10.2337/diabetes.55.01.06.db05-0954
Variants in the Human Insulin Gene That Affect Pre-mRNA Splicing: Is −23HphI a Functional Single Nucleotide Polymorphism at IDDM2?
Jana Královičová; Tom R. Gaunt; Santiago Rodriguez; Peter J. Wood; Ian N.M. Day; Igor Vořechovský
Diabetes January 2006, Vol.55, 260-264. doi:https://doi.org/10.2337/diabetes.55.01.06.db05-0773
Metabolism
Increased Lipid Availability Impairs Insulin-Stimulated ATP Synthesis in Human Skeletal Muscle
Diabetes January 2006, Vol.55, 136-140. doi:https://doi.org/10.2337/diabetes.55.01.06.db05-1286
Pathophysiology
Effects of Hyperglycemia and Hyperinsulinemia on Circulating Tissue Factor Procoagulant Activity and Platelet CD40 Ligand
Diabetes January 2006, Vol.55, 202-208. doi:https://doi.org/10.2337/diabetes.55.01.06.db05-1026
Phagocytic NADPH Oxidase Overactivity Underlies Oxidative Stress in Metabolic Syndrome
Diabetes January 2006, Vol.55, 209-215. doi:https://doi.org/10.2337/diabetes.55.01.06.db05-0751
Natural Antibiotics and Insulin Sensitivity: The Role of Bactericidal/Permeability-Increasing Protein
Carme Gubern; Abel López-Bermejo; Josefina Biarnés; Joan Vendrell; Wifredo Ricart; José Manuel Fernández-Real
Diabetes January 2006, Vol.55, 216-224. doi:https://doi.org/10.2337/diabetes.55.01.06.db05-1108
Pharmacology & Therapeutics
Muraglitazar, a Novel Dual (α/γ) Peroxisome Proliferator–Activated Receptor Activator, Improves Diabetes and Other Metabolic Abnormalities and Preserves β-Cell Function in db/db Mice
Thomas Harrity; Dennis Farrelly; Aaron Tieman; Cuixia Chu; Lori Kunselman; Liqun Gu; Randolph Ponticiello; Michael Cap; Fucheng Qu; Chunning Shao; Wei Wang; Hao Zhang; William Fenderson; Sean Chen; Pratik Devasthale; Yoon Jeon; Ramakrishna Seethala; Wen-Pin Yang; Jimmy Ren; Min Zhou; Denis Ryono; Scott Biller; Kasim A. Mookhtiar; John Wetterau; Richard Gregg; Peter T. Cheng; Narayanan Hariharan
Diabetes January 2006, Vol.55, 240-248. doi:https://doi.org/10.2337/diabetes.55.01.06.db05-0648
Genetics
Adiponectin Multimeric Complexes and the Metabolic Syndrome Trait Cluster
Diabetes January 2006, Vol.55, 249-259. doi:https://doi.org/10.2337/diabetes.55.01.06.db05-1105
