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Signal Transduction
Leptin Deficiency Unmasks the Deleterious Effects of Impaired Peroxisome Proliferator–Activated Receptor γ Function (P465L PPARγ) in Mice
Sarah L. Gray; Edoardo Dalla Nora; Johannes Grosse; Monia Manieri; Tobias Stoeger; Gema Medina-Gomez; Keith Burling; Sigrid Wattler; Andreas Russ; Giles S.H. Yeo; V. Krishna Chatterjee; Stephen O’Rahilly; Peter J. Voshol; Saverio Cinti; Antonio Vidal-Puig
Diabetes October 2006, Vol.55, 2669-2677. doi:https://doi.org/10.2337/db06-0389
Interleukin-6 Increases Insulin-Stimulated Glucose Disposal in Humans and Glucose Uptake and Fatty Acid Oxidation In Vitro via AMP-Activated Protein Kinase
Andrew L. Carey; Gregory R. Steinberg; S. Lance Macaulay; Walter G. Thomas; Anna G. Holmes; Georg Ramm; Oja Prelovsek; Cordula Hohnen-Behrens; Matthew J. Watt; David E. James; Bruce E. Kemp; Bente K. Pedersen; Mark A. Febbraio
Diabetes October 2006, Vol.55, 2688-2697. doi:https://doi.org/10.2337/db05-1404
Mechanisms of the Depot Specificity of Peroxisome Proliferator–Activated Receptor γ Action on Adipose Tissue Metabolism
Mathieu Laplante; William T. Festuccia; Geneviève Soucy; Yves Gélinas; Josée Lalonde; Joel P. Berger; Yves Deshaies
Diabetes October 2006, Vol.55, 2771-2778. doi:https://doi.org/10.2337/db06-0551
Palmitate-Mediated Downregulation of Peroxisome Proliferator–Activated Receptor-γ Coactivator 1α in Skeletal Muscle Cells Involves MEK1/2 and Nuclear Factor-κB Activation
Teresa Coll; Mireia Jové; Ricardo Rodríguez-Calvo; Elena Eyre; Xavier Palomer; Rosa M. Sánchez; Manuel Merlos; Juan Carlos Laguna; Manuel Vázquez-Carrera
Diabetes October 2006, Vol.55, 2779-2787. doi:https://doi.org/10.2337/db05-1494
Central and Opposing Effects of IGF-I and IGF-Binding Protein-3 on Systemic Insulin Action
Radhika H. Muzumdar; Xiaohui Ma; Sigal Fishman; Xiaoman Yang; Gil Atzmon; Patricia Vuguin; Francine H. Einstein; David Hwang; Pinchas Cohen; Nir Barzilai
Diabetes October 2006, Vol.55, 2788-2796. doi:https://doi.org/10.2337/db06-0318
Rosiglitazone Treatment Enhances Acute AMP-Activated Protein Kinase–Mediated Muscle and Adipose Tissue Glucose Uptake in High-Fat–Fed Rats
Diabetes October 2006, Vol.55, 2797-2804. doi:https://doi.org/10.2337/db05-1315
Obesity Studies
Impaired Adipose Tissue Development in Mice With Inactivation of Placental Growth Factor Function
H. Roger Lijnen; Valerie Christiaens; Ilse Scroyen; Gabor Voros; Marc Tjwa; Peter Carmeliet; Désiré Collen
Diabetes October 2006, Vol.55, 2698-2704. doi:https://doi.org/10.2337/db06-0526
Retinol-Binding Protein 4 in Human Obesity
Jürgen Janke; Stefan Engeli; Michael Boschmann; Frauke Adams; Jana Böhnke; Friedrich C. Luft; Arya M. Sharma; Jens Jordan
Diabetes October 2006, Vol.55, 2805-2810. doi:https://doi.org/10.2337/db06-0616
Lipin Expression Is Attenuated in Adipose Tissue of Insulin-Resistant Human Subjects and Increases With Peroxisome Proliferator–Activated Receptor γ Activation
Aiwei Yao-Borengasser; Neda Rasouli; Vijayalakshmi Varma; Leslie M. Miles; Bounleut Phanavanh; Tasha N. Starks; Jack Phan; Horace J. Spencer, III; Robert E. McGehee, Jr.; Karen Reue; Philip A. Kern
Diabetes October 2006, Vol.55, 2811-2818. doi:https://doi.org/10.2337/db05-1688
Islet Studies
STAT5 Activity in Pancreatic β-Cells Influences the Severity of Diabetes in Animal Models of Type 1 and 2 Diabetes
Malene Jackerott; Annette Møldrup; Peter Thams; Elisabeth D. Galsgaard; Jakob Knudsen; Ying C. Lee; Jens Høiriis Nielsen
Diabetes October 2006, Vol.55, 2705-2712. doi:https://doi.org/10.2337/db06-0244
Low Concentration of Interleukin-1β Induces FLICE-Inhibitory Protein–Mediated β-Cell Proliferation in Human Pancreatic Islets
Kathrin Maedler; Desiree M. Schumann; Nadine Sauter; Helga Ellingsgaard; Domenico Bosco; Reto Baertschiger; Yoichiro Iwakura; José Oberholzer; Claes B. Wollheim; Benoit R. Gauthier; Marc Y. Donath
Diabetes October 2006, Vol.55, 2713-2722. doi:https://doi.org/10.2337/db05-1430
Impact of Defined Matrix Interactions on Insulin Production by Cultured Human β-Cells: Effect on Insulin Content, Secretion, and Gene Transcription
Thomas Kaido; Mayra Yebra; Vincenzo Cirulli; Christopher Rhodes; Giuseppe Diaferia; Anthony M. Montgomery
Diabetes October 2006, Vol.55, 2723-2729. doi:https://doi.org/10.2337/db06-0120
Suppressed Insulin Signaling and Increased Apoptosis in Cd38-Null Islets
James D. Johnson; Eric L. Ford; Ernesto Bernal-Mizrachi; Kim L. Kusser; Dan S. Luciani; Zhiqiang Han; Hung Tran; Troy D. Randall; Frances E. Lund; Kenneth S. Polonsky
Diabetes October 2006, Vol.55, 2737-2746. doi:https://doi.org/10.2337/db05-1455
C16:0 Sulfatide Inhibits Insulin Secretion in Rat β-Cells by Reducing the Sensitivity of KATP Channels to ATP Inhibition
Diabetes October 2006, Vol.55, 2826-2834. doi:https://doi.org/10.2337/db05-1355
Identification of Insulin Signaling Elements in Human β-Cells: Autocrine Regulation of Insulin Gene Expression
Diabetes October 2006, Vol.55, 2835-2842. doi:https://doi.org/10.2337/db06-0532
Complications
Altered Gene Expression Related to Glomerulogenesis and Podocyte Structure in Early Diabetic Nephropathy of db/db Mice and Its Restoration by Pioglitazone
Hisashi Makino; Yoshihiro Miyamoto; Kazutomo Sawai; Kiyoshi Mori; Masashi Mukoyama; Kazuwa Nakao; Yasunao Yoshimasa; Shin-ichi Suga
Diabetes October 2006, Vol.55, 2747-2756. doi:https://doi.org/10.2337/db05-1683
A Selective Aldose Reductase Inhibitor of a New Structural Class Prevents or Reverses Early Retinal Abnormalities in Experimental Diabetic Retinopathy
Diabetes October 2006, Vol.55, 2757-2762. doi:https://doi.org/10.2337/db06-0138
Insulin Restores Metabolic Function in Cultured Cortical Neurons Subjected to Oxidative Stress
Diabetes October 2006, Vol.55, 2863-2870. doi:https://doi.org/10.2337/db06-0030
Genetics
Common Haplotypes at the Adiponectin Receptor 1 (ADIPOR1) Locus Are Associated With Increased Risk of Coronary Artery Disease in Type 2 Diabetes
Teresa Soccio; Yuan-Yuan Zhang; Simonetta Bacci; Wojciech Mlynarski; Grzegorz Placha; Greer Raggio; Rosa Di Paola; Antonella Marucci; Michael T. Johnstone; Ernest V. Gervino; Nada A. Abumrad; Samuel Klein; Vincenzo Trischitta; Alessandro Doria
Diabetes October 2006, Vol.55, 2763-2770. doi:https://doi.org/10.2337/db06-0613
Bardet-Biedl Syndrome Gene Variants Are Associated With Both Childhood and Adult Common Obesity in French Caucasians
Michael Benzinou; Andrew Walley; Stephan Lobbens; Marie-Aline Charles; Béatrice Jouret; Frédéric Fumeron; Beverley Balkau; David Meyre; Philippe Froguel
Diabetes October 2006, Vol.55, 2876-2882. doi:https://doi.org/10.2337/db06-0337
A Haplotype-Based Analysis of the PTPN22 Locus in Type 1 Diabetes
Diabetes October 2006, Vol.55, 2883-2889. doi:https://doi.org/10.2337/db06-0225
Pathophysiology
Immunoneutralization of Endogenous Glucagon Reduces Hepatic Glucose Output and Improves Long-Term Glycemic Control in Diabetic ob/ob Mice
Heidi Sørensen; Christian L. Brand; Susanne Neschen; Jens Juul Holst; Keld Fosgerau; Erica Nishimura; Gerald I. Shulman
Diabetes October 2006, Vol.55, 2843-2848. doi:https://doi.org/10.2337/db06-0222
Whole-Body Proteolysis Rate Is Elevated in HIV-Associated Insulin Resistance
Dominic N. Reeds; W. Todd Cade; Bruce W. Patterson; William G. Powderly; Samuel Klein; Kevin E. Yarasheski
Diabetes October 2006, Vol.55, 2849-2855. doi:https://doi.org/10.2337/db06-0255
Vitamin E and Risk of Type 2 Diabetes in the Women’s Health Study Randomized Controlled Trial
Simin Liu; I-Min Lee; Yiqing Song; Martin Van Denburgh; Nancy R. Cook; JoAnn E. Manson; Julie E. Buring
Diabetes October 2006, Vol.55, 2856-2862. doi:https://doi.org/10.2337/db06-0456
Pharmacology and Therapeutics
Serum Visfatin Increases With Progressive β-Cell Deterioration
Abel López-Bermejo; Berta Chico-Julià; Mercè Fernàndez-Balsells; Mònica Recasens; Eduardo Esteve; Roser Casamitjana; Wifredo Ricart; José-Manuel Fernández-Real
Diabetes October 2006, Vol.55, 2871-2875. doi:https://doi.org/10.2337/db06-0259
Brief Genetics Reports
Common Single Nucleotide Polymorphisms in TCF7L2 Are Reproducibly Associated With Type 2 Diabetes and Reduce the Insulin Response to Glucose in Nondiabetic Individuals
Richa Saxena; Lauren Gianniny; Noël P. Burtt; Valeriya Lyssenko; Candace Giuducci; Marketa Sjögren; Jose C. Florez; Peter Almgren; Bo Isomaa; Marju Orho-Melander; Ulf Lindblad; Mark J. Daly; Tiinamaija Tuomi; Joel N. Hirschhorn; Kristin G. Ardlie; Leif C. Groop; David Altshuler
Diabetes October 2006, Vol.55, 2890-2895. doi:https://doi.org/10.2337/db06-0381
Common Polymorphisms in the Promoter of the Visfatin Gene (PBEF1) Influence Plasma Insulin Levels in a French-Canadian Population
Swneke D. Bailey; J C. Loredo-Osti; Pierre Lepage; Janet Faith; Joelle Fontaine; Katia M. Desbiens; Thomas J. Hudson; Claude Bouchard; Daniel Gaudet; Louis Pérusse; Marie-Claude Vohl; James C. Engert
Diabetes October 2006, Vol.55, 2896-2902. doi:https://doi.org/10.2337/db06-0189
Transcription Factor TCF7L2 Genetic Study in the French Population: Expression in Human β-Cells and Adipose Tissue and Strong Association With Type 2 Diabetes
Stéphane Cauchi; David Meyre; Christian Dina; Hélène Choquet; Chantal Samson; Sophie Gallina; Beverley Balkau; Guillaume Charpentier; François Pattou; Volodymyr Stetsyuk; Raphaël Scharfmann; Bart Staels; Gema Frühbeck; Philippe Froguel
Diabetes October 2006, Vol.55, 2903-2908. doi:https://doi.org/10.2337/db06-0474
Role of a Proline Insertion in the Insulin Promoter Factor 1 (IPF1) Gene in African Americans With Type 2 Diabetes
Steven C. Elbein; Xiaoqin Wang; Mohammad A. Karim; Barry I. Freedman; Donald W. Bowden; Alan R. Shuldiner; Frederick L. Brancati; Wen Hong Linda Kao
Diabetes October 2006, Vol.55, 2909-2914. doi:https://doi.org/10.2337/db06-0434
IL6 Gene Promoter Polymorphisms and Type 2 Diabetes: Joint Analysis of Individual Participants’ Data From 21 Studies
Cornelia Huth; Iris M. Heid; Caren Vollmert; Christian Gieger; Harald Grallert; Johanna K. Wolford; Birgit Langer; Barbara Thorand; Norman Klopp; Yasmin H. Hamid; Oluf Pedersen; Torben Hansen; Valeriya Lyssenko; Leif Groop; Christa Meisinger; Angela Döring; Hannelore Löwel; Wolfgang Lieb; Christian Hengstenberg; Wolfgang Rathmann; Stephan Martin; Jeffrey W. Stephens; Helen Ireland; Hugh Mather; George J. Miller; Heather M. Stringham; Michael Boehnke; Jaakko Tuomilehto; Heiner Boeing; Matthias Möhlig; Joachim Spranger; Andreas Pfeiffer; Ingrid Wernstedt; Anders Niklason; Abel López-Bermejo; José-Manuel Fernández-Real; Robert L. Hanson; Luis Gallart; Joan Vendrell; Anastasia Tsiavou; Erifili Hatziagelaki; Steve E. Humphries; H.-Erich Wichmann; Christian Herder; Thomas Illig
Diabetes October 2006, Vol.55, 2915-2921. doi:https://doi.org/10.2337/db06-0600
The α-Adducin Gene Is Associated With Macrovascular Complications and Mortality in Patients With Type 2 Diabetes
Mojgan Yazdanpanah; Fakhredin A. Sayed-Tabatabaei; Albert Hofman; Yurii S. Aulchenko; Ben A. Oostra; Bruno H.C. Stricker; Huibert A.P. Pols; Steven W.J. Lamberts; Jacqueline C.M. Witteman; Joop A.M.J.L. Janssen; Cornelia M. van Duijn
Diabetes October 2006, Vol.55, 2922-2927. doi:https://doi.org/10.2337/db06-0302