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Volume 55, Issue 12
December 2006
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ISSN 0012-1797
EISSN 1939-327X
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Perspectives in Diabetes

Comparative Analysis of Insulin Gene Promoters : Implications for Diabetes Research
Colin W. Hay; Kevin Docherty
View articletitled, Comparative Analysis of Insulin Gene Promoters <span class="subtitle-colon">: </span><span class="subtitle">Implications for Diabetes Research</span>
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Diabetes December 2006, Vol.55, 3201-3213. doi:https://doi.org/10.2337/db06-0788

New Methodologies & Databases

Probe-Independent and Direct Quantification of Insulin mRNA and Growth Hormone mRNA in Enriched Cell Preparations
Leentje Van Lommel; Kristel Janssens; Roel Quintens; Katsura Tsukamoto; Dirk Vander Mierde; Katleen Lemaire; Carl Denef; Jean-Christophe Jonas; Geert Martens; Daniel Pipeleers; Frans C. Schuit
View articletitled, Probe-Independent and Direct Quantification of Insulin mRNA and Growth Hormone mRNA in Enriched Cell Preparations
Supplementary data
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Diabetes December 2006, Vol.55, 3214-3220. doi:https://doi.org/10.2337/db06-0774

Signal Transduction

Insulin-Mediated Phosphorylation of the Proline-Rich Akt Substrate PRAS40 Is Impaired in Insulin Target Tissues of High-Fat Diet–Fed Rats
Emmani B.M. Nascimento; Mariann Fodor; Gerard C.M. van der Zon; Ingrid M. Jazet; A. Edo Meinders; Peter J. Voshol; Ronald Vlasblom; Bart Baan; Jürgen Eckel; J. Antonie Maassen; Michaela Diamant; D. Margriet Ouwens
View articletitled, Insulin-Mediated Phosphorylation of the Proline-Rich Akt Substrate PRAS40 Is Impaired in Insulin Target Tissues of High-Fat Diet–Fed Rats
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Diabetes December 2006, Vol.55, 3221-3228. doi:https://doi.org/10.2337/db05-1390
Sodium-Coupled Glucose Cotransporters Contribute to Hypothalamic Glucose Sensing
Dervla O’Malley; Frank Reimann; Anna K. Simpson; Fiona M. Gribble
View articletitled, Sodium-Coupled Glucose Cotransporters Contribute to Hypothalamic Glucose Sensing
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Diabetes December 2006, Vol.55, 3381-3386. doi:https://doi.org/10.2337/db06-0531

Obesity Studies

Fatty Acid Transport Protein 1 Is Required for Nonshivering Thermogenesis in Brown Adipose Tissue
Qiwei Wu; Melissa Kazantzis; Holger Doege; Angelica M. Ortegon; Bernice Tsang; Alaric Falcon; Andreas Stahl
View articletitled, Fatty Acid Transport Protein 1 Is Required for Nonshivering Thermogenesis in Brown Adipose Tissue
Supplementary data
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Diabetes December 2006, Vol.55, 3229-3237. doi:https://doi.org/10.2337/db06-0749
Leptin Regulation of the Anorexic Response to Glucagon-Like Peptide-1 Receptor Stimulation
Diana L. Williams; Denis G. Baskin; Michael W. Schwartz
View articletitled, Leptin Regulation of the Anorexic Response to Glucagon-Like Peptide-1 Receptor Stimulation
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Diabetes December 2006, Vol.55, 3387-3393. doi:https://doi.org/10.2337/db06-0558
Endogenous ApoE Expression Modulates Adipocyte Triglyceride Content and Turnover
Zhi Hua Huang; Catherine A. Reardon; Theodore Mazzone
View articletitled, Endogenous ApoE Expression Modulates Adipocyte Triglyceride Content and Turnover
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Diabetes December 2006, Vol.55, 3394-3402. doi:https://doi.org/10.2337/db06-0354
Effects of Rimonabant (SR141716) on Fasting-Induced Hypothalamic-Pituitary-Adrenal Axis and Neuronal Activation in Lean and Obese Zucker Rats
Christian Doyon; Raphaël G. Denis; Elena-Dana Baraboi; Pierre Samson; Josée Lalonde; Yves Deshaies; Denis Richard
View articletitled, Effects of Rimonabant (SR141716) on Fasting-Induced Hypothalamic-Pituitary-Adrenal Axis and Neuronal Activation in Lean and Obese Zucker Rats
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Diabetes December 2006, Vol.55, 3403-3410. doi:https://doi.org/10.2337/db06-0504
Genetic Ablation of the c-Cbl Ubiquitin Ligase Domain Results in Increased Energy Expenditure and Improved Insulin Action
Juan C. Molero; Nigel Turner; Christine B.F. Thien; Wallace Y. Langdon; David E. James; Gregory J. Cooney
View articletitled, Genetic Ablation of the c-Cbl Ubiquitin Ligase Domain Results in Increased Energy Expenditure and Improved Insulin Action
Supplementary data
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Diabetes December 2006, Vol.55, 3411-3417. doi:https://doi.org/10.2337/db06-0955
OXPAT/PAT-1 Is a PPAR-Induced Lipid Droplet Protein That Promotes Fatty Acid Utilization
Nathan E. Wolins; Benjamin K. Quaynor; James R. Skinner; Anatoly Tzekov; Michelle A. Croce; Matthew C. Gropler; Vijayalakshmi Varma; Aiwei Yao-Borengasser; Neda Rasouli; Philip A. Kern; Brian N. Finck; Perry E. Bickel
View articletitled, OXPAT/PAT-1 Is a PPAR-Induced Lipid Droplet Protein That Promotes Fatty Acid Utilization
Supplementary data
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Diabetes December 2006, Vol.55, 3418-3428. doi:https://doi.org/10.2337/db06-0399
Lipin Deficiency Impairs Diurnal Metabolic Fuel Switching
Jun Xu; W.N. Paul Lee; Jack Phan; Mohammed F. Saad; Karen Reue; Irwin J. Kurland
View articletitled, Lipin Deficiency Impairs Diurnal Metabolic Fuel Switching
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Diabetes December 2006, Vol.55, 3429-3438. doi:https://doi.org/10.2337/db06-0260

Immunology and Transplantation

Effects of Autoimmunity and Immune Therapy on β-Cell Turnover in Type 1 Diabetes
Nicole A. Sherry; Jake A. Kushner; Mariela Glandt; Tadahiro Kitamura; Anne-Marie B. Brillantes; Kevan C. Herold
View articletitled, Effects of Autoimmunity and Immune Therapy on β-Cell Turnover in Type 1 Diabetes
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Diabetes December 2006, Vol.55, 3238-3245. doi:https://doi.org/10.2337/db05-1034
Expression of IGF-I in Pancreatic Islets Prevents Lymphocytic Infiltration and Protects Mice From Type 1 Diabetes
Alba Casellas; Ariana Salavert; Judith Agudo; Eduard Ayuso; Veronica Jimenez; Marta Moya; Sergio Muñoz; Sylvie Franckhauser; Fatima Bosch
View articletitled, Expression of IGF-I in Pancreatic Islets Prevents Lymphocytic Infiltration and Protects Mice From Type 1 Diabetes
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Diabetes December 2006, Vol.55, 3246-3255. doi:https://doi.org/10.2337/db06-0328
Recovery of Islet β-Cell Function in Streptozotocin- Induced Diabetic Mice : An Indirect Role for the Spleen
Dengping Yin; Jing Tao; David D. Lee; Jikun Shen; Manami Hara; James Lopez; Andrey Kuznetsov; Louis H. Philipson; Anita S. Chong
View articletitled, Recovery of Islet β-Cell Function in Streptozotocin- Induced Diabetic Mice <span class="subtitle-colon">: </span><span class="subtitle">An Indirect Role for the Spleen</span>
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Diabetes December 2006, Vol.55, 3256-3263. doi:https://doi.org/10.2337/db05-1275
Altered Monocyte Cyclooxygenase Response to Lipopolysaccharide in Type 1 Diabetes
Huriya Beyan; Martin R. Goodier; Niga S. Nawroly; Mohammed I. Hawa; Stephen A. Bustin; William B. Ogunkolade; Marco Londei; Nasim Yousaf; R. David G. Leslie
View articletitled, Altered Monocyte Cyclooxygenase Response to Lipopolysaccharide in Type 1 Diabetes
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Diabetes December 2006, Vol.55, 3439-3445. doi:https://doi.org/10.2337/db06-0447
Insulin Treatment in Patients With Type 1 Diabetes Induces Upregulation of Regulatory T-Cell Markers in Peripheral Blood Mononuclear Cells Stimulated With Insulin In Vitro
Minna Tiittanen; Johanna T. Huupponen; Mikael Knip; Outi Vaarala
View articletitled, Insulin Treatment in Patients With Type 1 Diabetes Induces Upregulation of Regulatory T-Cell Markers in Peripheral Blood Mononuclear Cells Stimulated With Insulin In Vitro
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Diabetes December 2006, Vol.55, 3446-3454. doi:https://doi.org/10.2337/db06-0132
Modulatory Role of DR4- to DQ8-restricted CD4 T-Cell Responses and Type 1 Diabetes Susceptibility
Xinhui Ge; Jon D. Piganelli; Hubert M. Tse; Suzanne Bertera; Clayton E. Mathews; Massimo Trucco; Li Wen; William A. Rudert
View articletitled, Modulatory Role of DR4- to DQ8-restricted CD4 T-Cell Responses and Type 1 Diabetes Susceptibility
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Diabetes December 2006, Vol.55, 3455-3462. doi:https://doi.org/10.2337/db06-0680

Islet Studies

Maintenance of Hepatic Nuclear Factor 6 in Postnatal Islets Impairs Terminal Differentiation and Function of β-Cells
Elizabeth Tweedie; Isabella Artner; Laura Crawford; Greg Poffenberger; Bernard Thorens; Roland Stein; Alvin C. Powers; Maureen Gannon
View articletitled, Maintenance of Hepatic Nuclear Factor 6 in Postnatal Islets Impairs Terminal Differentiation and Function of β-Cells
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Diabetes December 2006, Vol.55, 3264-3270. doi:https://doi.org/10.2337/db06-0090
The Cell Cycle Inhibitory Protein p21cip Is Not Essential for Maintaining β-Cell Cycle Arrest or β-Cell Function In Vivo
Irene Cozar-Castellano; Marcia Haught; Andrew F. Stewart
View articletitled, The Cell Cycle Inhibitory Protein p21<sup>cip</sup> Is Not Essential for Maintaining β-Cell Cycle Arrest or β-Cell Function In Vivo
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Diabetes December 2006, Vol.55, 3271-3278. doi:https://doi.org/10.2337/db06-0627
Protein Inhibitor of Neuronal Nitric Oxide Synthase (PIN) Is a New Regulator of Glucose-Induced Insulin Secretion
Anne-Dominique Lajoix; Stéphanie Badiou; Sylvie Péraldi-Roux; Thierry Chardès; Samuel Dietz; Cindy Aknin; Florence Tribillac; Pierre Petit; René Gross
View articletitled, Protein Inhibitor of Neuronal Nitric Oxide Synthase (PIN) Is a New Regulator of Glucose-Induced Insulin Secretion
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Diabetes December 2006, Vol.55, 3279-3288. doi:https://doi.org/10.2337/db06-0257
Regulation of Pancreatic β-Cell Regeneration in the Normoglycemic 60% Partial-Pancreatectomy Mouse
Mina Peshavaria; Brooke L. Larmie; James Lausier; Basanthi Satish; Aida Habibovic; Violet Roskens; Kyla LaRock; Brian Everill; Jack L. Leahy; Thomas L. Jetton
View articletitled, Regulation of Pancreatic β-Cell Regeneration in the Normoglycemic 60% Partial-Pancreatectomy Mouse
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Diabetes December 2006, Vol.55, 3289-3298. doi:https://doi.org/10.2337/db06-0017
Downregulation of EGF Receptor Signaling in Pancreatic Islets Causes Diabetes Due to Impaired Postnatal β-Cell Growth
Päivi J. Miettinen; Jarkko Ustinov; Päivi Ormio; Ru Gao; Jaan Palgi; Elina Hakonen; Lisa Juntti-Berggren; Per-Olof Berggren; Timo Otonkoski
View articletitled, Downregulation of EGF Receptor Signaling in Pancreatic Islets Causes Diabetes Due to Impaired Postnatal β-Cell Growth
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Diabetes December 2006, Vol.55, 3299-3308. doi:https://doi.org/10.2337/db06-0413
Glucagon Receptor Knockout Mice Display Increased Insulin Sensitivity and Impaired β-Cell Function
Heidi Sørensen; Maria Sörhede Winzell; Christian L. Brand; Keld Fosgerau; Richard W. Gelling; Erica Nishimura; Bo Ahren
View articletitled, Glucagon Receptor Knockout Mice Display Increased Insulin Sensitivity and Impaired β-Cell Function
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Diabetes December 2006, Vol.55, 3463-3469. doi:https://doi.org/10.2337/db06-0307
Nutrient Control of Insulin Secretion in Isolated Normal Human Islets
Jean-Claude Henquin; Denis Dufrane; Myriam Nenquin
View articletitled, Nutrient Control of Insulin Secretion in Isolated Normal Human Islets
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Diabetes December 2006, Vol.55, 3470-3477. doi:https://doi.org/10.2337/db06-0868
Modulation of Insulin Secretion by Fatty Acyl Analogs
Guy Las; Nina Mayorek; Kobie Dickstein; Jacob Bar-Tana
View articletitled, Modulation of Insulin Secretion by Fatty Acyl Analogs
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Diabetes December 2006, Vol.55, 3478-3485. doi:https://doi.org/10.2337/db06-0687
Blockade of Pancreatic Islet–Derived Ghrelin Enhances Insulin Secretion to Prevent High-Fat Diet–Induced Glucose Intolerance
Katsuya Dezaki; Hideyuki Sone; Masaru Koizumi; Masanori Nakata; Masafumi Kakei; Hideo Nagai; Hiroshi Hosoda; Kenji Kangawa; Toshihiko Yada
View articletitled, Blockade of Pancreatic Islet–Derived Ghrelin Enhances Insulin Secretion to Prevent High-Fat Diet–Induced Glucose Intolerance
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Diabetes December 2006, Vol.55, 3486-3493. doi:https://doi.org/10.2337/db06-0878
Separately Inherited Defects in Insulin Exocytosis and β-Cell Glucose Metabolism Contribute to Type 2 Diabetes
Charlotte Granhall; Anders H. Rosengren; Erik Renström; Holger Luthman
View articletitled, Separately Inherited Defects in Insulin Exocytosis and β-Cell Glucose Metabolism Contribute to Type 2 Diabetes
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Diabetes December 2006, Vol.55, 3494-3500. doi:https://doi.org/10.2337/db06-0796
Peroxisome Proliferator–Activated Receptor-α and Glucocorticoids Interactively Regulate Insulin Secretion During Pregnancy
Mark J. Holness; Gemma K. Greenwood; Nicholas D. Smith; Mary C. Sugden
View articletitled, Peroxisome Proliferator–Activated Receptor-α and Glucocorticoids Interactively Regulate Insulin Secretion During Pregnancy
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Diabetes December 2006, Vol.55, 3501-3508. doi:https://doi.org/10.2337/db06-0666
Contribution of Calcium Influx in Mediating Glucose-Stimulated Oxygen Consumption in Pancreatic Islets
Ian R. Sweet; Merle Gilbert
View articletitled, Contribution of Calcium Influx in Mediating Glucose-Stimulated Oxygen Consumption in Pancreatic Islets
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Diabetes December 2006, Vol.55, 3509-3519. doi:https://doi.org/10.2337/db06-0400
Differential Effects of p27 in Regulation of β-Cell Mass During Development, Neonatal Period, and Adult Life
Latif Rachdi; Norman Balcazar; Lynda Elghazi; Daniel J. Barker; Irina Krits; Hiroaki Kiyokawa; Ernesto Bernal-Mizrachi
View articletitled, Differential Effects of p27 in Regulation of β-Cell Mass During Development, Neonatal Period, and Adult Life
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Diabetes December 2006, Vol.55, 3520-3528. doi:https://doi.org/10.2337/db06-0861

Pathophysiology

Skeletal Muscle Mitochondrial Functions, Mitochondrial DNA Copy Numbers, and Gene Transcript Profiles in Type 2 Diabetic and Nondiabetic Subjects at Equal Levels of Low or High Insulin and Euglycemia
Yan W. Asmann; Craig S. Stump; Kevin R. Short; Jill M. Coenen-Schimke; ZengKui Guo; Maureen L. Bigelow; K. Sreekumaran Nair
View articletitled, Skeletal Muscle Mitochondrial Functions, Mitochondrial DNA Copy Numbers, and Gene Transcript Profiles in Type 2 Diabetic and Nondiabetic Subjects at Equal Levels of Low or High Insulin and Euglycemia
Supplementary data
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Diabetes December 2006, Vol.55, 3309-3319. doi:https://doi.org/10.2337/db05-1230
Effects of Sex and Hormone Replacement Therapy Use on the Prevalence of Isolated Impaired Fasting Glucose and Isolated Impaired Glucose Tolerance in Subjects With a Family History of Type 2 Diabetes
Renate E. van Genugten; Kristina M. Utzschneider; Jenny Tong; Fernando Gerchman; Sakeneh Zraika; Jayalakshmi Udayasankar; Edward J. Boyko; Wilfred Y. Fujimoto; Steven E. Kahn; and the American Diabetes Association GENNID Study Group
View articletitled, Effects of Sex and Hormone Replacement Therapy Use on the Prevalence of Isolated Impaired Fasting Glucose and Isolated Impaired Glucose Tolerance in Subjects With a Family History of Type 2 Diabetes
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Diabetes December 2006, Vol.55, 3529-3535. doi:https://doi.org/10.2337/db06-0577
Pathogenesis of Pre-Diabetes: Mechanisms of Fasting and Postprandial Hyperglycemia in People With Impaired Fasting Glucose and/or Impaired Glucose Tolerance
Gerlies Bock; Chiara Dalla Man; Marco Campioni; Elizabeth Chittilapilly; Rita Basu; Gianna Toffolo; Claudio Cobelli; Robert Rizza
View articletitled, Pathogenesis of Pre-Diabetes<span class="subtitle-colon">: </span><span class="subtitle">Mechanisms of Fasting and Postprandial Hyperglycemia in People With Impaired Fasting Glucose and/or Impaired Glucose Tolerance</span>
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Diabetes December 2006, Vol.55, 3536-3549. doi:https://doi.org/10.2337/db06-0319

Complications

Tau Is Hyperphosphorylated at Multiple Sites in Mouse Brain In Vivo After Streptozotocin-Induced Insulin Deficiency
Buffie J. Clodfelder-Miller; Anna A. Zmijewska; Gail V.W. Johnson; Richard S. Jope
View articletitled, Tau Is Hyperphosphorylated at Multiple Sites in Mouse Brain In Vivo After Streptozotocin-Induced Insulin Deficiency
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Diabetes December 2006, Vol.55, 3320-3325. doi:https://doi.org/10.2337/db06-0485
Hyperglycemia Inhibits Retinoic Acid–Induced Activation of Rac1, Prevents Differentiation of Cortical Neurons, and Causes Oxidative Stress in a Rat Model of Diabetic Pregnancy
Rakeshwar S. Guleria; Jing Pan; Donald DiPette; Ugra S. Singh
View articletitled, Hyperglycemia Inhibits Retinoic Acid–Induced Activation of Rac1, Prevents Differentiation of Cortical Neurons, and Causes Oxidative Stress in a Rat Model of Diabetic Pregnancy
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Diabetes December 2006, Vol.55, 3326-3334. doi:https://doi.org/10.2337/db06-0169
The Leptin-Deficient (ob/ob) Mouse: A New Animal Model of Peripheral Neuropathy of Type 2 Diabetes and Obesity
Viktor R. Drel; Nazar Mashtalir; Olga Ilnytska; Jeho Shin; Fei Li; Valeriy V. Lyzogubov; Irina G. Obrosova
View articletitled, The Leptin-Deficient (<em>ob/ob</em>) Mouse<span class="subtitle-colon">: </span><span class="subtitle">A New Animal Model of Peripheral Neuropathy of Type 2 Diabetes and Obesity</span>
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Diabetes December 2006, Vol.55, 3335-3343. doi:https://doi.org/10.2337/db06-0885
Irbesartan Treatment Reduces Biomarkers of Inflammatory Activity in Patients With Type 2 Diabetes and Microalbuminuria: An IRMA 2 Substudy
Frederik Persson; Peter Rossing; Peter Hovind; Coen D.A. Stehouwer; Casper Schalkwijk; Lise Tarnow; Hans-Henrik Parving
View articletitled, Irbesartan Treatment Reduces Biomarkers of Inflammatory Activity in Patients With Type 2 Diabetes and Microalbuminuria<span class="subtitle-colon">: </span><span class="subtitle">An IRMA 2 Substudy</span>
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Diabetes December 2006, Vol.55, 3550-3555. doi:https://doi.org/10.2337/db06-0827
The Effect of Intensive Glycemic Treatment on Coronary Artery Calcification in Type 1 Diabetic Participants of the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Study
Patricia A. Cleary; Trevor J. Orchard; Saul Genuth; Nathan D. Wong; Robert Detrano; Jye-Yu C. Backlund; Bernard Zinman; Alan Jacobson; Wanjie Sun; John M. Lachin; David M. Nathan; for the DCCT/EDIC Research Group
View articletitled, The Effect of Intensive Glycemic Treatment on Coronary Artery Calcification in Type 1 Diabetic Participants of the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Study
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Diabetes December 2006, Vol.55, 3556-3565. doi:https://doi.org/10.2337/db06-0653
Effect of Eucaloric High- and Low-Sucrose Diets With Identical Macronutrient Profile on Insulin Resistance and Vascular Risk: A Randomized Controlled Trial
R. Neil A. Black; Michelle Spence; Ross O. McMahon; Geraldine J. Cuskelly; Cieran N. Ennis; David R. McCance; Ian S. Young; Patrick M. Bell; Steven J. Hunter
View articletitled, Effect of Eucaloric High- and Low-Sucrose Diets With Identical Macronutrient Profile on Insulin Resistance and Vascular Risk<span class="subtitle-colon">: </span><span class="subtitle">A Randomized Controlled Trial</span>
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Diabetes December 2006, Vol.55, 3566-3572. doi:https://doi.org/10.2337/db06-0220
Diabetes Alters Sphingolipid Metabolism in the Retina: A Potential Mechanism of Cell Death in Diabetic Retinopathy
Todd E. Fox; Xianlin Han; Samuel Kelly; Alfred H. Merrill, Jr.; Rex E. Martin; Robert E. Anderson; Thomas W. Gardner; Mark Kester
View articletitled, Diabetes Alters Sphingolipid Metabolism in the Retina<span class="subtitle-colon">: </span><span class="subtitle">A Potential Mechanism of Cell Death in Diabetic Retinopathy</span>
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Diabetes December 2006, Vol.55, 3573-3580. doi:https://doi.org/10.2337/db06-0539
C-Peptide Reverses Nociceptive Neuropathy in Type 1 Diabetes
Hideki Kamiya; Weixian Zhang; Karin Ekberg; John Wahren; Anders A.F. Sima
View articletitled, C-Peptide Reverses Nociceptive Neuropathy in Type 1 Diabetes
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Diabetes December 2006, Vol.55, 3581-3587. doi:https://doi.org/10.2337/db06-0396
Reduced Expression of Gi in Erythrocytes of Humans With Type 2 Diabetes Is Associated With Impairment of Both cAMP Generation and ATP Release
Randy S. Sprague; Alan H. Stephenson; Elizabeth A. Bowles; Madelyn S. Stumpf; Andrew J. Lonigro
View articletitled, Reduced Expression of G<sub>i</sub> in Erythrocytes of Humans With Type 2 Diabetes Is Associated With Impairment of Both cAMP Generation and ATP Release
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Diabetes December 2006, Vol.55, 3588-3593. doi:https://doi.org/10.2337/db06-0555

Pharmacology & Therapeutics

Feasibility of Automating Insulin Delivery for the Treatment of Type 1 Diabetes
Garry M. Steil; Kerstin Rebrin; Christine Darwin; Farzam Hariri; Mohammed F. Saad
View articletitled, Feasibility of Automating Insulin Delivery for the Treatment of Type 1 Diabetes
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Diabetes December 2006, Vol.55, 3344-3350. doi:https://doi.org/10.2337/db06-0419
Treatment of Spontaneously Hypertensive Rats With Rosiglitazone and/or Enalapril Restores Balance Between Vasodilator and Vasoconstrictor Actions of Insulin With Simultaneous Improvement in Hypertension and Insulin Resistance
Maria A. Potenza; Flora L. Marasciulo; Mariela Tarquinio; Michael J. Quon; Monica Montagnani
View articletitled, Treatment of Spontaneously Hypertensive Rats With Rosiglitazone and/or Enalapril Restores Balance Between Vasodilator and Vasoconstrictor Actions of Insulin With Simultaneous Improvement in Hypertension and Insulin Resistance
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Diabetes December 2006, Vol.55, 3594-3603. doi:https://doi.org/10.2337/db06-0667
Inhalation of Human Insulin (Exubera) Augments the Efficiency of Muscle Glucose Uptake In Vivo
Dale S. Edgerton; Alan D. Cherrington; Phillip Williams; Doss W. Neal; Melanie Scott; Larry Bowen; Warren Wilson; Charles H. Hobbs; Chet Leach; Mei-chang Kuo; Thomas R. Strack
View articletitled, Inhalation of Human Insulin (Exubera) Augments the Efficiency of Muscle Glucose Uptake In Vivo
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Diabetes December 2006, Vol.55, 3604-3610. doi:https://doi.org/10.2337/db06-0718

Genetics

Introgression of F344 Rat Genomic DNA on BB Rat Chromosome 4 Generates Diabetes-Resistant Lymphopenic BB Rats
Jessica M. Fuller; Anne E. Kwitek; Tyson J. Hawkins; Daniel H. Moralejo; Wen Lu; Terry D. Tupling; Armand J. MacMurray; Gretta Borchardt; Michael Hasinoff; Åke Lernmark
View articletitled, Introgression of F344 Rat Genomic DNA on BB Rat Chromosome 4 Generates Diabetes-Resistant Lymphopenic BB Rats
Supplementary data
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Diabetes December 2006, Vol.55, 3351-3357. doi:https://doi.org/10.2337/db06-0715
A Genome-Wide Linkage Scan for Genes Controlling Variation in Renal Function Estimated by Serum Cystatin C Levels in Extended Families With Type 2 Diabetes
Grzegorz Placha; G. David Poznik; Jonathon Dunn; Adam Smiles; Bozena Krolewski; Timothy Glew; Sobha Puppala; Jennifer Schneider; John J. Rogus; Stephen S. Rich; Ravindranath Duggirala; James H. Warram; Andrzej S. Krolewski
View articletitled, A Genome-Wide Linkage Scan for Genes Controlling Variation in Renal Function Estimated by Serum Cystatin C Levels in Extended Families With Type 2 Diabetes
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Diabetes December 2006, Vol.55, 3358-3365. doi:https://doi.org/10.2337/db06-0781
The Idd4 Locus Displays Sex-Specific Epistatic Effects on Type 1 Diabetes Susceptibility in Nonobese Diabetic Mice
Evgueni A. Ivakine; Steven M. Mortin-Toth; Omid M. Gulban; Aneta Valova; Angelo Canty; Christopher Scott; Jayne S. Danska
View articletitled, The Idd4 Locus Displays Sex-Specific Epistatic Effects on Type 1 Diabetes Susceptibility in Nonobese Diabetic Mice
Supplementary data
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Diabetes December 2006, Vol.55, 3611-3619. doi:https://doi.org/10.2337/db06-0758

Brief Genetics Reports

Hyperphagia, Severe Obesity, Impaired Cognitive Function, and Hyperactivity Associated With Functional Loss of One Copy of the Brain-Derived Neurotrophic Factor (BDNF) Gene
Juliette Gray; Giles S.H. Yeo; James J. Cox; Jenny Morton; Anna-Lynne R. Adlam; Julia M. Keogh; Jack A. Yanovski; Areeg El Gharbawy; Joan C. Han; Y.C. Loraine Tung; John R. Hodges; F. Lucy Raymond; Stephen O’Rahilly; I. Sadaf Farooqi
View articletitled, Hyperphagia, Severe Obesity, Impaired Cognitive Function, and Hyperactivity Associated With Functional Loss of One Copy of the Brain-Derived Neurotrophic Factor (<em>BDNF</em>) Gene
Supplementary data
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Diabetes December 2006, Vol.55, 3366-3371. doi:https://doi.org/10.2337/db06-0550
The Krüppel-Like Factor 11 (KLF11) Q62R Polymorphism Is Not Associated With Type 2 Diabetes in 8,676 People
Jose C. Florez; Richa Saxena; Wendy Winckler; Noël P. Burtt; Peter Almgren; Kristina Bengtsson Boström; Tiinamaija Tuomi; Daniel Gaudet; Kristin G. Ardlie; Mark J. Daly; David Altshuler; Joel N. Hirschhorn; Leif Groop
View articletitled, The Krüppel-Like Factor 11 (KLF11) Q62R Polymorphism Is Not Associated With Type 2 Diabetes in 8,676 People
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Diabetes December 2006, Vol.55, 3620-3624. doi:https://doi.org/10.2337/db06-0867
CHRM3 Gene Variation Is Associated With Decreased Acute Insulin Secretion and Increased Risk for Early-Onset Type 2 Diabetes in Pima Indians
Yan Guo; Michael Traurig; Lijun Ma; Sayuko Kobes; Inge Harper; Aniello M. Infante; Clifton Bogardus; Leslie J. Baier; Michal Prochazka
View articletitled, <em>CHRM3</em> Gene Variation Is Associated With Decreased Acute Insulin Secretion and Increased Risk for Early-Onset Type 2 Diabetes in Pima Indians
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Diabetes December 2006, Vol.55, 3625-3629. doi:https://doi.org/10.2337/db06-0379
Polymorphism in the Transcription Factor 7-Like 2 (TCF7L2) Gene Is Associated With Reduced Insulin Secretion in Nondiabetic Women
Julian Munoz; Kerry H. Lok; Barbara A. Gower; Jose R. Fernandez; Gary R. Hunter; Cristina Lara-Castro; Maria De Luca; W. Timothy Garvey
View articletitled, Polymorphism in the Transcription Factor 7-Like 2 (<em>TCF7L2</em>) Gene Is Associated With Reduced Insulin Secretion in Nondiabetic Women
Supplementary data
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Diabetes December 2006, Vol.55, 3630-3634. doi:https://doi.org/10.2337/db06-0574

Metabolism

Decreased Hepatic Futile Cycling Compensates for Increased Glucose Disposal in the Pten Heterodeficient Mouse
Jun Xu; Lori Gowen; Christian Raphalides; Katrina K. Hoyer; Jason G. Weinger; Mathilde Renard; Joshua J. Troke; Bhavapriya Vaitheesyaran; W.N. Paul Lee; Mohammed F. Saad; Mark W. Sleeman; Michael A. Teitell; Irwin J. Kurland
View articletitled, Decreased Hepatic Futile Cycling Compensates for Increased Glucose Disposal in the <em>Pten</em> Heterodeficient Mouse
Supplementary data
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Diabetes December 2006, Vol.55, 3372-3380. doi:https://doi.org/10.2337/db06-0002

Erratum

Errata
View articletitled, Errata
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Diabetes December 2006, Vol.55, 3635. doi:https://doi.org/10.2337/db06-er12
Errata
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Diabetes December 2006, Vol.55, 3635. doi:https://doi.org/10.2337/db06-er12a
Système International (SI) Units Table
Management of Latent Autoimmune Diabetes in Adults: A Consensus Statement From an International Expert Panel
713-P: Is There a Correct Time to Measure Fasting Blood Sugar in Persons with Type 2 Diabetes Melitus?
300-OR: Beneficial Effect of the Combination Therapy of Cagrilintide, a Dual Amylin/Calcitonin Agonist, and Tirzepatide, a Dual GLP-1/GIP Agonist, on Body Weight Loss in Obese Rats
Elevated First-Trimester Neutrophil Count Is Closely Associated With the Development of Maternal Gestational Diabetes Mellitus and Adverse Pregnancy Outcomes
  • Online ISSN 1939-327X
  • Print ISSN 0012-1797

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