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Signal Transduction
Glucose-Dependent Transcriptional Regulation by an Evolutionarily Conserved Glucose-Sensing Module
Diabetes May 2006, Vol.55, 1179-1189. doi:https://doi.org/10.2337/db05-0822
Transcription Factor FoxO1 Mediates Glucagon-Like Peptide-1 Effects on Pancreatic β-Cell Mass
Diabetes May 2006, Vol.55, 1190-1196. doi:https://doi.org/10.2337/db05-0825
Impact of Mitochondrial Reactive Oxygen Species and Apoptosis Signal–Regulating Kinase 1 on Insulin Signaling
Koujiro Imoto; Daisuke Kukidome; Takeshi Nishikawa; Takako Matsuhisa; Kazuhiro Sonoda; Kazuo Fujisawa; Miyuki Yano; Hiroyuki Motoshima; Tetsuya Taguchi; Kaku Tsuruzoe; Takeshi Matsumura; Hidenori Ichijo; Eiichi Araki
Diabetes May 2006, Vol.55, 1197-1204. doi:https://doi.org/10.2337/db05-1187
Methylglyoxal Impairs the Insulin Signaling Pathways Independently of the Formation of Intracellular Reactive Oxygen Species
Audrey Riboulet-Chavey; Anne Pierron; Isabelle Durand; Joseph Murdaca; Jean Giudicelli; Emmanuel Van Obberghen
Diabetes May 2006, Vol.55, 1289-1299. doi:https://doi.org/10.2337/db05-0857
Imaging of Insulin Signaling in Skeletal Muscle of Living Mice Shows Major Role of T-Tubules
Diabetes May 2006, Vol.55, 1300-1306. doi:https://doi.org/10.2337/db05-1216
Phosphatidylinositol 3-Kinase–Dependent Activation of Akt, an Essential Signal for Hyperthermia-Induced Heat-Shock Protein 72, Is Attenuated in Streptozotocin-Induced Diabetic Heart
Tetsuji Shinohara; Naohiko Takahashi; Tatsuhiko Ooie; Masahide Hara; Sakuji Shigematsu; Mikiko Nakagawa; Hidetoshi Yonemochi; Tetsunori Saikawa; Hironobu Yoshimatsu
Diabetes May 2006, Vol.55, 1307-1315. doi:https://doi.org/10.2337/db05-0266
Intestinal Insulin Resistance and Aberrant Production of Apolipoprotein B48 Lipoproteins in an Animal Model of Insulin Resistance and Metabolic Dyslipidemia : Evidence for Activation of Protein Tyrosine Phosphatase-1B, Extracellular Signal–Related Kinase, and Sterol Regulatory Element–Binding Protein-1c in the Fructose-Fed Hamster Intestine
Diabetes May 2006, Vol.55, 1316-1326. doi:https://doi.org/10.2337/db04-1084
Obesity Studies
Mature-Onset Obesity in Interleukin-1 Receptor I Knockout Mice
Maria C. García; Ingrid Wernstedt; Anna Berndtsson; Maria Enge; Michal Bell; Olof Hultgren; Michael Horn; Bo Ahrén; Sven Enerback; Claes Ohlsson; Ville Wallenius; John-Olov Jansson
Diabetes May 2006, Vol.55, 1205-1213. doi:https://doi.org/10.2337/db05-1304
Tamoxifen-Induced Anorexia Is Associated With Fatty Acid Synthase Inhibition in the Ventromedial Nucleus of the Hypothalamus and Accumulation of Malonyl-CoA
Miguel López; Christopher J. Lelliott; Sulay Tovar; Wendy Kimber; Rosalía Gallego; Sam Virtue; Margaret Blount; Maria J. Vázquez; Nick Finer; Trevor J. Powles; Stephen O’Rahilly; Asish K. Saha; Carlos Diéguez; Antonio J. Vidal-Puig
Diabetes May 2006, Vol.55, 1327-1336. doi:https://doi.org/10.2337/db05-1356
Sex-Discordant Associations With Adiponectin Levels and Lipid Profiles in Children
Ken K. Ong; Jan Frystyk; Allan Flyvbjerg; Clive J. Petry; the Avon Longitudinal Study of Parents and Children Study Team; Andy Ness; David B. Dunger
Diabetes May 2006, Vol.55, 1337-1341. doi:https://doi.org/10.2337/db05-1272
NFATc4 and ATF3 Negatively Regulate Adiponectin Gene Expression in 3T3-L1 Adipocytes
Hyun Bae Kim; Minyoung Kong; Tae Min Kim; Young Ho Suh; Won-Ho Kim; Joo Hyun Lim; Ji Hyun Song; Myeong Ho Jung
Diabetes May 2006, Vol.55, 1342-1352. doi:https://doi.org/10.2337/db05-1507
Regional Differences in Adipose Tissue Metabolism in Women : Minor Effect of Obesity and Body Fat Distribution
André Tchernof; Chantal Bélanger; Anne-Sophie Morisset; Christian Richard; Jacques Mailloux; Philippe Laberge; Pierre Dupont
Diabetes May 2006, Vol.55, 1353-1360. doi:https://doi.org/10.2337/db05-1439
Immunology and Transplantation
The Class I HLA Repertoire of Pancreatic Islets Comprises the Nonclassical Class Ib Antigen HLA-G
Vincenzo Cirulli; Jessie Zalatan; Michael McMaster; Robyn Prinsen; Daniel R. Salomon; Camillo Ricordi; Bruce E. Torbett; Paolo Meda; Laura Crisa
Diabetes May 2006, Vol.55, 1214-1222. doi:https://doi.org/10.2337/db05-0731
Effect of Donor Age on Function of Isolated Human Islets
Sung-Hee Ihm; Ippei Matsumoto; Toshiya Sawada; Masahiko Nakano; Hui J. Zhang; Jeffrey D. Ansite; David E.R. Sutherland; Bernhard J. Hering
Diabetes May 2006, Vol.55, 1361-1368. doi:https://doi.org/10.2337/db05-1333
Islet Studies
Evidence for a Role of the Ubiquitin-Proteasome Pathway in Pancreatic Islets
María D. López-Avalos; Valérie F. Duvivier-Kali; Gang Xu; Susan Bonner-Weir; Arun Sharma; Gordon C. Weir
Diabetes May 2006, Vol.55, 1223-1231. doi:https://doi.org/10.2337/db05-0450
Activation of Glucagon-Like Peptide-1 Receptor Signaling Does Not Modify the Growth or Apoptosis of Human Pancreatic Cancer Cells
Diabetes May 2006, Vol.55, 1369-1379. doi:https://doi.org/10.2337/db05-1145
Dexamethasone Induces Cell Death in Insulin-Secreting Cells, an Effect Reversed by Exendin-4
Felicia Ranta; Diana Avram; Susanne Berchtold; Martina Düfer; Gisela Drews; Florian Lang; Susanne Ullrich
Diabetes May 2006, Vol.55, 1380-1390. doi:https://doi.org/10.2337/db05-1220
Pro- and Antiapoptotic Proteins Regulate Apoptosis but Do Not Protect Against Cytokine-Mediated Cytotoxicity in Rat Islets and β-Cell Lines
Diabetes May 2006, Vol.55, 1398-1406. doi:https://doi.org/10.2337/db05-1000
Blockade of β1 Integrin–Laminin-5 Interaction Affects Spreading and Insulin Secretion of Rat β-Cells Attached on Extracellular Matrix
Geraldine Parnaud; Eva Hammar; Dominique G. Rouiller; Mathieu Armanet; Philippe A. Halban; Domenico Bosco
Diabetes May 2006, Vol.55, 1413-1420. doi:https://doi.org/10.2337/db05-1388
Munc13-1 Deficiency Reduces Insulin Secretion and Causes Abnormal Glucose Tolerance
Edwin P. Kwan; Li Xie; Laura Sheu; Christopher J. Nolan; Marc Prentki; Andrea Betz; Nils Brose; Herbert Y. Gaisano
Diabetes May 2006, Vol.55, 1421-1429. doi:https://doi.org/10.2337/db05-1263
Complications
2-(8-Hydroxy-6-Methoxy-1-Oxo-1H-2-Benzopyran-3-yl) Propionic Acid, an Inhibitor of Angiogenesis, Ameliorates Renal Alterations in Obese Type 2 Diabetic Mice
Kunihiro Ichinose; Yohei Maeshima; Yoshihiko Yamamoto; Masaru Kinomura; Kumiko Hirokoshi; Hiroyuki Kitayama; Yuki Takazawa; Hitoshi Sugiyama; Yasushi Yamasaki; Naoki Agata; Hirofumi Makino
Diabetes May 2006, Vol.55, 1232-1242. doi:https://doi.org/10.2337/db05-1367
Human Vascular Smooth Muscle Cells From Diabetic Patients Are Resistant to Induced Apoptosis Due to High Bcl-2 Expression
Emilio Ruiz; Antonio Gordillo-Moscoso; Eugenia Padilla; Santiago Redondo; Enrique Rodriguez; Fernando Reguillo; Ana M. Briones; Cornelis van Breemen; Elena Okon; Teresa Tejerina
Diabetes May 2006, Vol.55, 1243-1251. doi:https://doi.org/10.2337/db05-0949
Diabetes-Induced Activation of Canonical and Noncanonical Nuclear Factor-κB Pathways in Renal Cortex
Jonathan M. Starkey; Sigmund J. Haidacher; Wanda S. LeJeune; Xiaoquan Zhang; Brian C. Tieu; Sanjeev Choudhary; Allan R. Brasier; Larry A. Denner; Ronald G. Tilton
Diabetes May 2006, Vol.55, 1252-1259. doi:https://doi.org/10.2337/db05-1554
Insulin Resistance and Microalbuminuria : A Cross-Sectional, Case-Control Study of 158 Patients With Type 2 Diabetes and Different Degrees of Urinary Albumin Excretion
Aneliya I. Parvanova; Roberto Trevisan; Ilian P. Iliev; Borislav D. Dimitrov; Monica Vedovato; Antonio Tiengo; Giuseppe Remuzzi; Piero Ruggenenti
Diabetes May 2006, Vol.55, 1456-1462. doi:https://doi.org/10.2337/db05-1484
The 30-Year Natural History of Type 1 Diabetes Complications: The Pittsburgh Epidemiology of Diabetes Complications Study Experience
Georgia Pambianco; Tina Costacou; Demetrius Ellis; Dorothy J. Becker; Ronald Klein; Trevor J. Orchard
Diabetes May 2006, Vol.55, 1463-1469. doi:https://doi.org/10.2337/db05-1423
Effects of Basic Fibroblast Growth Factor on Experimental Diabetic Neuropathy in Rats
Mika Nakae; Hideki Kamiya; Keiko Naruse; Naoichi Horio; Yasuki Ito; Ryuichi Mizubayashi; Yoji Hamada; Eitaro Nakashima; Noboru Akiyama; Yasuko Kobayashi; Atsuko Watarai; Nachi Kimura; Masayuki Horiguchi; Yasuhiko Tabata; Yutaka Oiso; Jiro Nakamura
Diabetes May 2006, Vol.55, 1470-1477. doi:https://doi.org/10.2337/db05-1160
Aldose Reductase Pathway Inhibition Improved Vascular and C-Fiber Functions, Allowing for Pressure-Induced Vasodilation Restoration During Severe Diabetic Neuropathy
Claire Demiot; Maylis Tartas; Bérengère Fromy; Pierre Abraham; Jean Louis Saumet; Dominique Sigaudo-Roussel
Diabetes May 2006, Vol.55, 1478-1483. doi:https://doi.org/10.2337/db05-1433
Brief Genetics Reports
Hepatocyte Nuclear Factor-4α P2 Promoter Haplotypes Are Associated With Type 2 Diabetes in the Japanese Population
Kazuo Hara; Momoko Horikoshi; Hiroji Kitazato; Chikako Ito; Mitsuhiko Noda; Jun Ohashi; Philippe Froguel; Katsushi Tokunaga; Kazuyuki Tobe; Ryozo Nagai; Takashi Kadowaki
Diabetes May 2006, Vol.55, 1260-1264. doi:https://doi.org/10.2337/db05-0620
Multi-SNP Analysis of MHC Region: Remarkable Conservation of HLA-A1-B8-DR3 Haplotype
Theresa A. Aly; Elise Eller; Akane Ide; Katherine Gowan; Sunanda R. Babu; Henry A. Erlich; Marian J. Rewers; George S. Eisenbarth; Pamela R. Fain
Diabetes May 2006, Vol.55, 1265-1269. doi:https://doi.org/10.2337/db05-1276
The ATGL Gene Is Associated With Free Fatty Acids, Triglycerides, and Type 2 Diabetes
Veit Schoenborn; Iris M. Heid; Caren Vollmert; Arno Lingenhel; Ted D. Adams; Paul N. Hopkins; Thomas Illig; Robert Zimmermann; Rudolf Zechner; Steven C. Hunt; Florian Kronenberg
Diabetes May 2006, Vol.55, 1270-1275. doi:https://doi.org/10.2337/db05-1498
Variants of the Interleukin-10 Promoter Gene Are Associated With Obesity and Insulin Resistance but Not Type 2 Diabetes in Caucasian Italian Subjects
Daniela Scarpelli; Marina Cardellini; Francesco Andreozzi; Emanuela Laratta; Marta Letizia Hribal; Maria Adelaide Marini; Vittorio Tassi; Renato Lauro; Francesco Perticone; Giorgio Sesti
Diabetes May 2006, Vol.55, 1529-1533. doi:https://doi.org/10.2337/db06-0047
Metabolism
Metabolic Sensors Mediate Hypoglycemic Detection at the Portal Vein
Diabetes May 2006, Vol.55, 1276-1282. doi:https://doi.org/10.2337/db05-1665
Pathophysiology
Insulin Secretion and Action in Subjects With Impaired Fasting Glucose and Impaired Glucose Tolerance : Results From the Veterans Administration Genetic Epidemiology Study
Muhammad A. Abdul-Ghani; Christopher P. Jenkinson; Dawn K. Richardson; Devjit Tripathy; Ralph A. DeFronzo
Diabetes May 2006, Vol.55, 1430-1435. doi:https://doi.org/10.2337/db05-1200
Obesity Blunts Insulin-Mediated Microvascular Recruitment in Human Forearm Muscle
Lucy H. Clerk; Michelle A. Vincent; Linda A. Jahn; Zhenqi Liu; Jonathan R. Lindner; Eugene J. Barrett
Diabetes May 2006, Vol.55, 1436-1442. doi:https://doi.org/10.2337/db05-1373
Zonulin Upregulation Is Associated With Increased Gut Permeability in Subjects With Type 1 Diabetes and Their Relatives
Anna Sapone; Laura de Magistris; Michelle Pietzak; Maria G. Clemente; Amit Tripathi; Francesco Cucca; Rosanna Lampis; Deborah Kryszak; Maria Cartenì; Maddalena Generoso; Dario Iafusco; Francesco Prisco; Francesca Laghi; Gabriele Riegler; Romano Carratu; Debra Counts; Alessio Fasano
Diabetes May 2006, Vol.55, 1443-1449. doi:https://doi.org/10.2337/db05-1593
Pharmacology & Therapeutics
Improvement of Glucose Tolerance and Hepatic Insulin Sensitivity by Oligofructose Requires a Functional Glucagon-Like Peptide 1 Receptor
Patrice D. Cani; Claude Knauf; Miguel A. Iglesias; Daniel J. Drucker; Nathalie M. Delzenne; Rémy Burcelin
Diabetes May 2006, Vol.55, 1484-1490. doi:https://doi.org/10.2337/db05-1360
Plasma Phospholipid Transfer Protein Activity Is Decreased in Type 2 Diabetes During Treatment With Atorvastatin : A Role for Apolipoprotein E?
Geesje M. Dallinga-Thie; Arie van Tol; Hiroaki Hattori; Patrick C.N. Rensen; Eric J.G. Sijbrands; for the Diabetes Atorvastatin Lipid Intervention (DALI) Study Group
Diabetes May 2006, Vol.55, 1491-1496. doi:https://doi.org/10.2337/db05-1685
Genetics
A Functional Tyr1306Cys Variant in LARG Is Associated With Increased Insulin Action in Vivo
Diabetes May 2006, Vol.55, 1497-1503. doi:https://doi.org/10.2337/db05-1331
Variation in the UCP2-UCP3 Gene Cluster Predicts the Development of Type 2 Diabetes in Healthy Middle-Aged Men
Diabetes May 2006, Vol.55, 1504-1511. doi:https://doi.org/10.2337/db05-1645
Differential Transmission of Type 1 Diabetes from Diabetic Fathers and Mothers to Their Offspring
Diabetes May 2006, Vol.55, 1517-1524. doi:https://doi.org/10.2337/db05-1296